LISTADO DE SECUENCIAS <110> APOGENIX GMBH <120> PROTEÍNAS AGONISTAS DE LOS RECEPTORES DE TRAIL DE CADENA SIMPLE <130> 566215: BBI-999PC <140> PCT/US2015/27270 <141> 23-04-2015 <150> 61/983152 <151> 23-04-2014 <160> 31 <170> PatentIn versión 3.5 <210> 1 <211> 281 <212> PRT <213> Homo sapiens <220> <221> fuente <223> /nota=“TRAIL humano” <400> 1 Met Ala Met Met Glu Val Gln Gly Gly Pro Ser Leu Gly Gln Thr Cys 1 5 10 15 Val Leu Ile Val Ile Phe Thr Val Leu Leu Gln Ser Leu Cys Val Ala 20 25 30 Val Thr Tyr Val Tyr Phe Thr Asn Glu Leu Lys Gln Met Gln Asp Lys 35 40 45 Tyr Ser Lys Ser Gly Ile Ala Cys Phe Leu Lys Glu Asp Asp Ser Tyr 50 55 60 Trp Asp Pro Asn Asp Glu Glu Ser Met Asn Ser Pro Cys Trp Gln Val 65 70 75 80 Lys Trp Gln Leu Arg Gln Leu Val Arg Lys Met Ile Leu Arg Thr Ser 85 90 95 Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile Ser Pro 100 105 110 Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly 115 120 125 Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu 130 135 140 Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly 145 150 155 160 His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile 165 170 175 His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe 180 185 190 Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln 195 200 205 Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys 210 215 220 Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr 225 230 235 240 Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile 245 250 255 Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala 260 265 270 Ser Phe Phe Gly Ala Phe Leu Val Gly 275 280 <210> 2 <211> 8 <212> PRT <213> Secuencia artificial <220> <221> fuente <223> /nota=“Descripción de Secuencia artificial: Péptido conector sintético <400> 2 Gly Ser Gly Ser Gly Asn Gly Ser 1 5 <210> 3 <211> 8 <212> PRT <213> Secuencia artificial <220> <221> fuente <223> /nota=“Descripción de Secuencia artificial: Péptido conector sintético <400> 3 Gly Ser Gly Ser Gly Ser Gly Ser 1 5 <210> 4 <211> 8 <212> PRT <213> Secuencia artificial <220> <221> fuente <223> /nota=“Descripción de Secuencia artificial: Péptido conector sintético <400> 4 Gly Gly Ser Gly Ser Gly Ser Gly 1 5 <210> 5 <211> 6 <212> PRT <213> Secuencia artificial <220> <221> fuente <223> /nota=“Descripción de Secuencia artificial: Péptido conector sintético <400> 5 Gly Gly Ser Gly Ser Gly 1 5 <210> 6 <211> 4 <212> PRT <213> Secuencia artificial <220> <221> fuente <223> /nota=“Descripción de Secuencia artificial: Péptido conector sintético <400> 6 Gly Gly Ser Gly 1 <210> 7 <211> 8 <212> PRT <213> Secuencia artificial <220> <221> fuente <223> /nota=“Descripción de Secuencia artificial: Péptido conector sintético <400> 7 Gly Gly Ser Gly Asn Gly Ser Gly 1 5 <210> 8 <211> 8 <212> PRT <213> Secuencia artificial <220> <221> fuente <223> /nota=“Descripción de Secuencia artificial: Péptido conector sintético <400> 8 Gly Gly Asn Gly Ser Gly Ser Gly 1 5 <210> 9 <211> 6 <212> PRT <213> Secuencia artificial <220> <221> fuente <223> /nota=“Descripción de Secuencia artificial: Péptido conector sintético <400> 9 Gly Gly Asn Gly Ser Gly 1 5 <210> 10 <211> 218 <212> PRT <213> Secuencia artificial <220> <221> fuente <223> /nota=“Descripción de Secuencia artificial: Fragmento de un anticuerpo del tipo Fc sintético <400> 10 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 1 5 10 15 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 20 25 30 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 35 40 45 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 50 55 60 Glu Gln Tyr Ser Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 65 70 75 80 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 85 90 95 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 100 105 110 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 115 120 125 Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 130 135 140 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 145 150 155 160 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 165 170 175 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 180 185 190 Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 195 200 205 Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 210 215 <210> 11 <211> 22 <212> PRT <213> Secuencia artificial <220> <221> fuente <223> /nota=“Descripción de Secuencia artificial: Conector sintético que hace las veces de bisagra <400> 11 Gly Pro Gly Ser Ser Ser Ser Ser Ser Ser Gly Ser Cys Asp Lys Thr 1 5 10 15 His Thr Cys Pro Pro Cys 20 <210> 12 <211> 20 <212> PRT <213> Secuencia artificial <220> <221> fuente <223> /nota=“Descripción de Secuencia artificial: Péptido señal sintético" <400> 12 Met Glu Thr Asp Thr Leu Leu Val Phe Val Leu Leu Val Trp Val Pro 1 5 10 15 Ala Gly Asn Gly 20 <210> 13 <211> 15 <212> PRT <213> Secuencia artificial <220> <221> fuente <223> /nota=“Descripción de Secuencia artificial: péptido conector que comprende serina y una marca del tipo Strep " <400> 13 Ser Ser Ser Ser Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys 1 5 10 15 <210> 14 <211> 760 <212> PRT <213> Secuencia artificial <220> <221> fuente <223> /nota=“Descripción de Secuencia artificial: polipéptido de fusión de cadena simple sintético " <400> 14 Met Glu Thr Asp Thr Leu Leu Val Phe Val Leu Leu Val Trp Val Pro 1 5 10 15 Ala Gly Asn Gly Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly 20 25 30 Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu 35 40 45 Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe 50 55 60 Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys 65 70 75 80 Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu 85 90 95 Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr 100 105 110 Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg 115 120 125 Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr 130 135 140 Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser 145 150 155 160 Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe 165 170 175 Gly Ala Phe Leu Val Gly Gly Ser Gly Ser Gly Asn Gly Ser Arg Val 180 185 190 Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser 195 200 205 Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp 210 215 220 Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg 225 230 235 240 Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser 245 250 255 Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn 260 265 270 Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp 275 280 285 Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp 290 295 300 Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu 305 310 315 320 Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile 325 330 335 Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Gly 340 345 350 Ser Gly Ser Gly Asn Gly Ser Arg Val Ala Ala His Ile Thr Gly Thr 355 360 365 Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys 370 375 380 Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His 385 390 395 400 Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His 405 410 415 Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln 420 425 430 Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr 435 440 445 Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser 450 455 460 Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser 465 470 475 480 Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe 485 490 495 Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser 500 505 510 Phe Phe Gly Ala Phe Leu Val Gly Gly Pro Gly Ser Ser Ser Ser Ser 515 520 525 Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 530 535 540 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 545 550 555 560 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 565 570 575 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 580 585 590 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 595 600 605 Tyr Ser Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 610 615 620 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 625 630 635 640 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 645 650 655 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 660 665 670 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 675 680 685 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 690 695 700 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 705 710 715 720 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 725 730 735 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 740 745 750 Ser Leu Ser Leu Ser Pro Gly Lys 755 760 <210> 15 <211> 774 <212> PRT <213> Secuencia artificial <220> <221> fuente <223> /nota=“Descripción de Secuencia artificial: polipéptido de fusión de cadena simple sintético <400> 15 Met Glu Thr Asp Thr Leu Leu Val Phe Val Leu Leu Val Trp Val Pro 1 5 10 15 Ala Gly Asn Gly Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly 20 25 30 Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu 35 40 45 Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe 50 55 60 Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys 65 70 75 80 Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu 85 90 95 Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr 100 105 110 Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg 115 120 125 Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr 130 135 140 Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser 145 150 155 160 Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe 165 170 175 Gly Ala Phe Leu Val Gly Gly Ser Gly Ser Gly Asn Gly Ser Arg Val 180 185 190 Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser 195 200 205 Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp 210 215 220 Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg 225 230 235 240 Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser 245 250 255 Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn 260 265 270 Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp 275 280 285 Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp 290 295 300 Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu 305 310 315 320 Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile 325 330 335 Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Gly 340 345 350 Ser Gly Ser Gly Asn Gly Ser Arg Val Ala Ala His Ile Thr Gly Thr 355 360 365 Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys 370 375 380 Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His 385 390 395 400 Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His 405 410 415 Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln 420 425 430 Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr 435 440 445 Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser 450 455 460 Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser 465 470 475 480 Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe 485 490 495 Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser 500 505 510 Phe Phe Gly Ala Phe Leu Val Gly Gly Pro Gly Ser Ser Ser Ser Ser 515 520 525 Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 530 535 540 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 545 550 555 560 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 565 570 575 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 580 585 590 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 595 600 605 Tyr Ser Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 610 615 620 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 625 630 635 640 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 645 650 655 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 660 665 670 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 675 680 685 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 690 695 700 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 705 710 715 720 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 725 730 735 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 740 745 750 Ser Leu Ser Leu Ser Pro Gly Ser Ser Ser Ser Ser Ser Ala Trp Ser 755 760 765 His Pro Gln Phe Glu Lys 770 <210> 16 <211> 2316 <212> DNA <213> Secuencia artificial <220> <221> fuente <223> /nota=“Descripción de Secuencia artificial: secuencia de un polinucleótido de ADN sintético que codifica un polipéptido de fusión de cadena simple <400> 16 gatatcggta ccgccaccat ggaaaccgac accctgctgg tgttcgtgct gctcgtgtgg 60 gtgccagccg gcaatggaca gagagtggcc gctcatatca ccggcacccg gggcagatct 120 aacaccctgt ccagccccaa ctccaagaac gagaaggccc tgggccggaa gatcaactcc 180 tgggagtcct ccagatccgg ccactccttt ctgtccaacc tgcacctgag aaacggcgag 240 ctggtcatcc acgagaaggg cttctactac atctactccc agacctactt caggtttcag 300 gaagagatca aagagaacac aaagaacgac aagcagatgg tgcagtatat ctacaagtac 360 acctcctacc ccgaccccat cctgctgatg aagtccgccc ggaactcctg ctggtccaag 420 gatgctgagt acggcctgta cagcatctac cagggcggca tcttcgagct gaaagagaac 480 gaccggatct tcgtgtccgt gaccaacgag cacctgatcg acatggacca cgaggccagc 540 tttttcggcg cctttctcgt gggcggatcc ggaagcggaa acggcagtag agtggctgcc 600 cacattaccg gaaccagagg ccggtccaac accctgagca gccctaacag caaaaatgag 660 aaagctctcg ggcgcaagat caacagctgg gaatctagca gaagcggcca cagctttctg 720 agcaatctgc atctgcggaa cggcgaactc gtgattcatg agaaggggtt ttattatatc 780 tatagccaga catactttcg attccaggag gaaatcaagg aaaacaccaa aaatgataaa 840 cagatggtcc agtacattta taagtatacc agctaccctg atcctatcct cctcatgaag 900 tctgccagaa actcttgttg gagcaaggac gccgagtatg gactgtactc tatctatcag 960 ggggggatct ttgaactcaa agaaaacgat cgcatctttg tcagcgtcac caatgagcat 1020 ctcattgata tggatcatga agctagtttc ttcggggcat tcctcgtggg aggctccggc 1080 tctggcaacg gatctagagt cgccgcacac atcacaggga ccagaggcag aagcaatacc 1140 ctgtcctccc caaatagtaa aaacgaaaag gcactcggcc gcaaaattaa ttcctgggag 1200 agcagcagat ccgggcacag ttttctgtct aatctccatc tgaggaatgg ggagctggtg 1260 attcacgaaa aaggatttta ctacatttac agtcagactt actttcgttt tcaggaagag 1320 attaaggaaa ataccaaaaa cgacaagcag atggtccagt acatctataa atacacctct 1380 tatcctgacc caattctgct catgaagagt gcccgcaaca gctgctggtc taaagacgcc 1440 gaatacgggc tgtattccat ttaccagggg ggaatttttg agctgaagga aaatgatcgg 1500 atttttgtct ctgtcacaaa cgaacacctc atcgatatgg atcacgaagc ctctttcttt 1560 ggcgccttcc tggtcggagg ccctggctcg agttccagct cctcttctgg ctcctgcgac 1620 aagacccaca cctgtccccc ttgtcctgcc cctgaactgc tgggcggacc ttccgtgttc 1680 ctgttccccc caaagcccaa ggacaccctg atgatctccc ggacccccga agtgacctgc 1740 gtggtggtgg atgtgtctca cgaggaccct gaagtgaagt tcaattggta cgtggacggc 1800 gtggaagtgc acaacgccaa gaccaagccc agagaggaac agtactcctc cacctaccgg 1860 gtggtgtctg tgctgaccgt gctgcaccag gactggctga acggcaaaga gtacaagtgc 1920 aaggtgtcca acaaggccct gcctgccccc atcgaaaaga ccatctccaa ggccaagggc 1980 cagccccggg aaccccaggt gtacacactg ccccctagcc gggaagagat gaccaagaac 2040 caggtgtccc tgacctgcct ggtcaagggc ttttacccct ccgacattgc cgtggaatgg 2100 gagtccaacg gccagcctga gaacaactac aagaccaccc cccctgtgct ggactccgac 2160 ggctcattct tcctgtactc caagctgaca gtggacaagt cccggtggca gcagggcaac 2220 gtgttctcct gctccgtgat gcacgaggcc ctgcacaacc actacaccca gaagtccctg 2280 tccctgagcc ccggcaaatg atagaagctt gatatc 2316 <210> 17 <211> 217 <212> PRT <213> Secuencia artificial <220> <221> fuente <223> /nota=“Descripción de Secuencia artificial: polipéptido que es una variante mutada de un fragmento Fc humano sintético <400> 17 Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 1 5 10 15 Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 20 25 30 Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 35 40 45 Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 50 55 60 Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 65 70 75 80 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 85 90 95 Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 100 105 110 Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 115 120 125 Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 130 135 140 Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 145 150 155 160 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 165 170 175 Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 180 185 190 Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 195 200 205 Lys Ser Leu Ser Leu Ser Pro Gly Lys 210 215 <210> 18 <211> 759 <212> PRT <213> Secuencia artificial <220> <221> fuente <223> /nota=“Descripción de Secuencia artificial: polipéptido sintético <400> 18 Met Glu Thr Asp Thr Leu Leu Val Phe Val Leu Leu Val Trp Val Pro 1 5 10 15 Ala Gly Asn Gly Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly 20 25 30 Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu 35 40 45 Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe 50 55 60 Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys 65 70 75 80 Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu 85 90 95 Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr 100 105 110 Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg 115 120 125 Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr 130 135 140 Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser 145 150 155 160 Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe 165 170 175 Gly Ala Phe Leu Val Gly Gly Ser Gly Ser Gly Asn Gly Ser Arg Val 180 185 190 Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser 195 200 205 Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp 210 215 220 Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg 225 230 235 240 Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser 245 250 255 Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn 260 265 270 Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp 275 280 285 Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp 290 295 300 Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu 305 310 315 320 Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile 325 330 335 Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Gly 340 345 350 Ser Gly Ser Gly Asn Gly Ser Arg Val Ala Ala His Ile Thr Gly Thr 355 360 365 Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys 370 375 380 Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His 385 390 395 400 Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His 405 410 415 Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln 420 425 430 Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr 435 440 445 Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser 450 455 460 Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser 465 470 475 480 Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe 485 490 495 Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser 500 505 510 Phe Phe Gly Ala Phe Leu Val Gly Gly Pro Gly Ser Ser Ser Ser Ser 515 520 525 Ser Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 530 535 540 Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 545 550 555 560 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 565 570 575 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 580 585 590 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 595 600 605 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 610 615 620 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 625 630 635 640 Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 645 650 655 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 660 665 670 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 675 680 685 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 690 695 700 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 705 710 715 720 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 725 730 735 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 740 745 750 Leu Ser Leu Ser Pro Gly Lys 755 <210> 19 <211> 740 <212> PRT <213> Secuencia artificial <220> <221> fuente <223> /nota=“Descripción de Secuencia artificial: polipéptido sintético <400> 19 Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr 1 5 10 15 Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile 20 25 30 Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu 35 40 45 His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr 50 55 60 Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn 65 70 75 80 Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser 85 90 95 Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp 100 105 110 Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile 115 120 125 Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu 130 135 140 His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu 145 150 155 160 Val Gly Gly Ser Gly Ser Gly Asn Gly Ser Arg Val Ala Ala His Ile 165 170 175 Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys 180 185 190 Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg 195 200 205 Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu 210 215 220 Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe 225 230 235 240 Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met 245 250 255 Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu 260 265 270 Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly 275 280 285 Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp 290 295 300 Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His 305 310 315 320 Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Gly Ser Gly Ser Gly 325 330 335 Asn Gly Ser Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser 340 345 350 Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg 355 360 365 Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser 370 375 380 Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe 385 390 395 400 Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys 405 410 415 Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr 420 425 430 Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser 435 440 445 Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly 450 455 460 Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr 465 470 475 480 Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala 485 490 495 Phe Leu Val Gly Gly Pro Gly Ser Ser Ser Ser Ser Ser Ser Gly Ser 500 505 510 Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 515 520 525 Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 530 535 540 Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 545 550 555 560 His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 565 570 575 Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ser Ser Thr 580 585 590 Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 595 600 605 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 610 615 620 Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 625 630 635 640 Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 645 650 655 Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 660 665 670 Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 675 680 685 Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 690 695 700 Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 705 710 715 720 Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 725 730 735 Ser Pro Gly Lys 740 <210> 20 <211> 754 <212> PRT <213> Secuencia artificial <220> <221> fuente <223> /nota=“Descripción de Secuencia artificial: polipéptido sintético <400> 20 Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr 1 5 10 15 Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile 20 25 30 Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu 35 40 45 His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr 50 55 60 Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn 65 70 75 80 Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser 85 90 95 Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp 100 105 110 Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile 115 120 125 Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu 130 135 140 His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu 145 150 155 160 Val Gly Gly Ser Gly Ser Gly Asn Gly Ser Arg Val Ala Ala His Ile 165 170 175 Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys 180 185 190 Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg 195 200 205 Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu 210 215 220 Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe 225 230 235 240 Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met 245 250 255 Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu 260 265 270 Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly 275 280 285 Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp 290 295 300 Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His 305 310 315 320 Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Gly Ser Gly Ser Gly 325 330 335 Asn Gly Ser Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser 340 345 350 Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg 355 360 365 Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser 370 375 380 Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe 385 390 395 400 Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys 405 410 415 Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr 420 425 430 Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser 435 440 445 Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly 450 455 460 Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr 465 470 475 480 Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala 485 490 495 Phe Leu Val Gly Gly Pro Gly Ser Ser Ser Ser Ser Ser Ser Gly Ser 500 505 510 Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 515 520 525 Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 530 535 540 Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 545 550 555 560 His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 565 570 575 Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ser Ser Thr 580 585 590 Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 595 600 605 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 610 615 620 Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 625 630 635 640 Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 645 650 655 Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 660 665 670 Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 675 680 685 Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 690 695 700 Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 705 710 715 720 Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 725 730 735 Ser Pro Gly Ser Ser Ser Ser Ser Ser Ala Trp Ser His Pro Gln Phe 740 745 750 Glu Lys <210> 21 <211> 739 <212> PRT <213> Secuencia artificial <220> <221> fuente <223> /nota=“Descripción de Secuencia artificial: Polipéptido sintético" <400> 21 Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr 1 5 10 15 Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile 20 25 30 Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu 35 40 45 His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr 50 55 60 Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn 65 70 75 80 Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser 85 90 95 Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp 100 105 110 Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile 115 120 125 Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu 130 135 140 His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu 145 150 155 160 Val Gly Gly Ser Gly Ser Gly Asn Gly Ser Arg Val Ala Ala His Ile 165 170 175 Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys 180 185 190 Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg 195 200 205 Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu 210 215 220 Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe 225 230 235 240 Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met 245 250 255 Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu 260 265 270 Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly 275 280 285 Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp 290 295 300 Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His 305 310 315 320 Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Gly Ser Gly Ser Gly 325 330 335 Asn Gly Ser Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser 340 345 350 Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg 355 360 365 Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser 370 375 380 Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe 385 390 395 400 Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys 405 410 415 Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr 420 425 430 Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser 435 440 445 Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly 450 455 460 Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr 465 470 475 480 Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala 485 490 495 Phe Leu Val Gly Gly Pro Gly Ser Ser Ser Ser Ser Ser Ser Gly Ser 500 505 510 Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 515 520 525 Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 530 535 540 Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 545 550 555 560 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 565 570 575 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 580 585 590 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 595 600 605 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 610 615 620 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 625 630 635 640 Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 645 650 655 Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 660 665 670 Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 675 680 685 Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 690 695 700 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 705 710 715 720 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 725 730 735 Pro Gly Lys <210> 22 <211> 6 <212> PRT <213> Secuencia artificial <220> <221> fuente <223> /nota=“Descripción de Secuencia artificial: Péptido sintético" <400> 22 Gly Ser Gly Ser Gly Ser 1 5 <210> 23 <211> 4 <212> PRT <213> Secuencia artificial <220> <221> fuente <223> /nota=“Descripción de Secuencia artificial: Péptido sintético" <400> 23 Gly Ser Gly Ser 1 <210> 24 <211> 3 <212> PRT <213> Secuencia artificial <220> <221> fuente <223> /nota=“Descripción de Secuencia artificial: Péptido sintético" <400> 24 Gly Ser Gly 1 <210> 25 <211> 21 <212> PRT <213> Secuencia artificial <220> <221> fuente <223> /nota=“Descripción de Secuencia artificial: Péptido sintético" <400> 25 Gly Pro Gly Ser Ser Ser Ser Ser Ser Gly Ser Cys Asp Lys Thr His 1 5 10 15 Thr Cys Pro Pro Cys 20 <210> 26 <211> 751 <212> PRT <213> Secuencia artificial <220> <221> fuente <223> /nota=“Descripción de Secuencia artificial: Polipéptido sintético" <400> 26 Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr 1 5 10 15 Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile 20 25 30 Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu 35 40 45 His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr 50 55 60 Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn 65 70 75 80 Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser 85 90 95 Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp 100 105 110 Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile 115 120 125 Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu 130 135 140 His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu 145 150 155 160 Val Gly Gly Ser Gly Ser Gly Asn Gly Ser Arg Val Ala Ala His Ile 165 170 175 Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys 180 185 190 Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg 195 200 205 Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu 210 215 220 Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe 225 230 235 240 Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met 245 250 255 Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu 260 265 270 Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly 275 280 285 Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp 290 295 300 Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His 305 310 315 320 Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Gly Ser Gly Ser Gly 325 330 335 Asn Gly Ser Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser 340 345 350 Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg 355 360 365 Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser 370 375 380 Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe 385 390 395 400 Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys 405 410 415 Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr 420 425 430 Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser 435 440 445 Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly 450 455 460 Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr 465 470 475 480 Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala 485 490 495 Phe Leu Val Gly Gly Pro Gly Ser Ser Ser Ser Ser Ser Gly Ser Asp 500 505 510 Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 515 520 525 Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 530 535 540 Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 545 550 555 560 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 565 570 575 Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 580 585 590 Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 595 600 605 Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 610 615 620 Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 625 630 635 640 Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 645 650 655 Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 660 665 670 Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 675 680 685 Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 690 695 700 Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 705 710 715 720 Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 725 730 735 Ser Ser Ser Ser Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys 740 745 750 <210> 27 <211> 750 <212> PRT <213> Secuencia artificial <220> <221> fuente <223> /nota=“Descripción de Secuencia artificial: Polipéptido sintético" <400> 27 Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr 1 5 10 15 Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile 20 25 30 Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu 35 40 45 His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr 50 55 60 Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn 65 70 75 80 Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser 85 90 95 Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp 100 105 110 Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile 115 120 125 Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu 130 135 140 His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu 145 150 155 160 Val Gly Gly Ser Gly Ser Gly Asn Gly Ser Arg Val Ala Ala His Ile 165 170 175 Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys 180 185 190 Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg 195 200 205 Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu 210 215 220 Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe 225 230 235 240 Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met 245 250 255 Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu 260 265 270 Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly 275 280 285 Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp 290 295 300 Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His 305 310 315 320 Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Gly Ser Gly Ser Arg 325 330 335 Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser 340 345 350 Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser 355 360 365 Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu 370 375 380 Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr 385 390 395 400 Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys 405 410 415 Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro 420 425 430 Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys 435 440 445 Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu 450 455 460 Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu 465 470 475 480 Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly 485 490 495 Gly Pro Gly Ser Ser Ser Ser Ser Ser Ser Gly Ser Cys Asp Lys Thr 500 505 510 His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 515 520 525 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 530 535 540 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 545 550 555 560 Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 565 570 575 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ser Ser Thr Tyr Arg Val Val 580 585 590 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 595 600 605 Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 610 615 620 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 625 630 635 640 Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 645 650 655 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 660 665 670 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 675 680 685 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 690 695 700 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 705 710 715 720 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser 725 730 735 Ser Ser Ser Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys 740 745 750 <210> 28 <211> 750 <212> PRT <213> Secuencia artificial <220> <221> fuente <223> /nota=“Descripción de Secuencia artificial: Polipéptido sintético" <400> 28 Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr 1 5 10 15 Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile 20 25 30 Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu 35 40 45 His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr 50 55 60 Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn 65 70 75 80 Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser 85 90 95 Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp 100 105 110 Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile 115 120 125 Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu 130 135 140 His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu 145 150 155 160 Val Gly Gly Ser Gly Ser Gly Ser Arg Val Ala Ala His Ile Thr Gly 165 170 175 Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu 180 185 190 Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly 195 200 205 His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile 210 215 220 His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe 225 230 235 240 Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln 245 250 255 Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys 260 265 270 Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr 275 280 285 Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile 290 295 300 Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala 305 310 315 320 Ser Phe Phe Gly Ala Phe Leu Val Gly Gly Ser Gly Ser Gly Ser Arg 325 330 335 Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser 340 345 350 Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser 355 360 365 Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu 370 375 380 Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr 385 390 395 400 Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys 405 410 415 Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro 420 425 430 Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys 435 440 445 Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu 450 455 460 Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu 465 470 475 480 Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly 485 490 495 Gly Pro Gly Ser Ser Ser Ser Ser Ser Ser Gly Ser Cys Asp Lys Thr 500 505 510 His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 515 520 525 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 530 535 540 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 545 550 555 560 Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 565 570 575 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ser Ser Thr Tyr Arg Val Val 580 585 590 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 595 600 605 Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 610 615 620 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 625 630 635 640 Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 645 650 655 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 660 665 670 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 675 680 685 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 690 695 700 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 705 710 715 720 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser 725 730 735 Ser Ser Ser Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys 740 745 750 <210> 29 <211> 736 <212> PRT <213> Secuencia artificial <220> <221> fuente <223> /nota=“Descripción de Secuencia artificial: Polipéptido sintético" <400> 29 Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr 1 5 10 15 Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile 20 25 30 Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu 35 40 45 His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr 50 55 60 Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn 65 70 75 80 Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser 85 90 95 Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp 100 105 110 Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile 115 120 125 Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu 130 135 140 His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu 145 150 155 160 Val Gly Gly Ser Gly Ser Gly Asn Gly Ser Arg Val Ala Ala His Ile 165 170 175 Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys 180 185 190 Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg 195 200 205 Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu 210 215 220 Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe 225 230 235 240 Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met 245 250 255 Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu 260 265 270 Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly 275 280 285 Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp 290 295 300 Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His 305 310 315 320 Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Gly Ser Gly Ser Arg 325 330 335 Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser 340 345 350 Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser 355 360 365 Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu 370 375 380 Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr 385 390 395 400 Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys 405 410 415 Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro 420 425 430 Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys 435 440 445 Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu 450 455 460 Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu 465 470 475 480 Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly 485 490 495 Gly Pro Gly Ser Ser Ser Ser Ser Ser Ser Gly Ser Cys Asp Lys Thr 500 505 510 His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 515 520 525 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 530 535 540 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 545 550 555 560 Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 565 570 575 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ser Ser Thr Tyr Arg Val Val 580 585 590 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 595 600 605 Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 610 615 620 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 625 630 635 640 Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 645 650 655 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 660 665 670 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 675 680 685 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 690 695 700 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 705 710 715 720 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 725 730 735 <210> 30 <211> 736 <212> PRT <213> Secuencia artificial <220> <221> fuente <223> /nota=“Descripción de Secuencia artificial: Polipéptido sintético" <400> 30 Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr 1 5 10 15 Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile 20 25 30 Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu 35 40 45 His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr 50 55 60 Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn 65 70 75 80 Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser 85 90 95 Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp 100 105 110 Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile 115 120 125 Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu 130 135 140 His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu 145 150 155 160 Val Gly Gly Ser Gly Ser Gly Ser Arg Val Ala Ala His Ile Thr Gly 165 170 175 Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu 180 185 190 Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly 195 200 205 His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile 210 215 220 His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe 225 230 235 240 Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln 245 250 255 Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys 260 265 270 Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr 275 280 285 Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile 290 295 300 Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala 305 310 315 320 Ser Phe Phe Gly Ala Phe Leu Val Gly Gly Ser Gly Ser Gly Ser Arg 325 330 335 Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser 340 345 350 Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser 355 360 365 Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu 370 375 380 Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr 385 390 395 400 Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys 405 410 415 Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro 420 425 430 Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys 435 440 445 Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu 450 455 460 Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu 465 470 475 480 Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly 485 490 495 Gly Pro Gly Ser Ser Ser Ser Ser Ser Ser Gly Ser Cys Asp Lys Thr 500 505 510 His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 515 520 525 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 530 535 540 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 545 550 555 560 Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 565 570 575 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ser Ser Thr Tyr Arg Val Val 580 585 590 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 595 600 605 Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 610 615 620 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 625 630 635 640 Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 645 650 655 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 660 665 670 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 675 680 685 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 690 695 700 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 705 710 715 720 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 725 730 735 <210> 31 <211> 4 <212> PRT <213> Secuencia artificial <220> <221> fuente <223> /nota=“Descripción de Secuencia artificial: Péptido sintético" <400> 31 Asp Glu Val Asp 1