SEQUENCE LISTING <110> AMGEN INC. SANTA MARIA BIOTHERAPEUTICS, INC. <120> FORMULATED RECEPTOR POLYPEPTIDES AND RELATED METHODS <130> 29957-29502 PCT <140> PCT/US2015/035818 <141> 2015-06-15 <150> 62/142,812 <151> 2015-04-03 <150> 62/058,789 <151> 2014-10-02 <150> 62/047,995 <151> 2014-09-09 <150> 61/012,104 <151> 2014-06-13 <160> 53 <170> PatentIn version 3.5 <210> 1 <211> 402 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(402) <400> 1 atg acg gcg ccc tgg gtg gcc ctc gcc ctc ctc tgg gga tcg ctg tgc 48 Met Thr Ala Pro Trp Val Ala Leu Ala Leu Leu Trp Gly Ser Leu Cys 1 5 10 15 gcc ggc tct ggg cgt ggg gag gct gag aca cgg gag tgc atc tac tac 96 Ala Gly Ser Gly Arg Gly Glu Ala Glu Thr Arg Glu Cys Ile Tyr Tyr 20 25 30 aac gcc aac tgg gag ctg gag cgc acc aac cag agc ggc ctg gag cgc 144 Asn Ala Asn Trp Glu Leu Glu Arg Thr Asn Gln Ser Gly Leu Glu Arg 35 40 45 tgc gaa ggc gag cag gac aag cgg ctg cac tgc tac gcc tcc tgg cgc 192 Cys Glu Gly Glu Gln Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg 50 55 60 aac agc tct ggc acc atc gag ctc gtg aag aag ggc tgc tgg cta gat 240 Asn Ser Ser Gly Thr Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp 65 70 75 80 gac ttc aac tgc tac gat agg cag gag tgt gtg gcc act gag gag aac 288 Asp Phe Asn Cys Tyr Asp Arg Gln Glu Cys Val Ala Thr Glu Glu Asn 85 90 95 ccc cag gtg tac ttc tgc tgc tgt gaa ggc aac ttc tgc aac gag cgc 336 Pro Gln Val Tyr Phe Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg 100 105 110 ttc act cat ttg cca gag gct ggg ggc ccg gaa gtc acg tac gag cca 384 Phe Thr His Leu Pro Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro 115 120 125 ccc ccg aca gcc ccc acc 402 Pro Pro Thr Ala Pro Thr 130 <210> 2 <211> 134 <212> PRT <213> Homo sapiens <400> 2 Met Thr Ala Pro Trp Val Ala Leu Ala Leu Leu Trp Gly Ser Leu Cys 1 5 10 15 Ala Gly Ser Gly Arg Gly Glu Ala Glu Thr Arg Glu Cys Ile Tyr Tyr 20 25 30 Asn Ala Asn Trp Glu Leu Glu Arg Thr Asn Gln Ser Gly Leu Glu Arg 35 40 45 Cys Glu Gly Glu Gln Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg 50 55 60 Asn Ser Ser Gly Thr Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp 65 70 75 80 Asp Phe Asn Cys Tyr Asp Arg Gln Glu Cys Val Ala Thr Glu Glu Asn 85 90 95 Pro Gln Val Tyr Phe Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg 100 105 110 Phe Thr His Leu Pro Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro 115 120 125 Pro Pro Thr Ala Pro Thr 130 <210> 3 <211> 387 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(387) <400> 3 atg gag ttt ggg ctg agc tgg gtt ttc ctc gtt gct ctt tta aga ggt 48 Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 1 5 10 15 gtc cag tgt gag aca cgg tgg tgc atc tac tac aac gcc aac tgg gag 96 Val Gln Cys Glu Thr Arg Trp Cys Ile Tyr Tyr Asn Ala Asn Trp Glu 20 25 30 ctg gag cgc acc aac cag acc ggc ctg gag cgc tgc gaa ggc gag cag 144 Leu Glu Arg Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln 35 40 45 gac aag cgg ctg cac tgc tac gcc tcc tgg cgc aac agc tct ggc acc 192 Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr 50 55 60 atc gag ctc gtg aag aag ggc tgc tgg cta gat gac ttc aac tgc tac 240 Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr 65 70 75 80 gat agg cag gag tgt gtg gcc act gag gag aac ccc cag gtg tac ttc 288 Asp Arg Gln Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe 85 90 95 tgc tgc tgt gag ggc aac ttc tgc aac gag cgc ttc act cat ttg cca 336 Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro 100 105 110 gag gct ggg ggc ccg gaa gtc acg tac gag cca ccc ccg aca gcc ccc 384 Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro 115 120 125 acc 387 Thr <210> 4 <211> 129 <212> PRT <213> Homo sapiens <400> 4 Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 1 5 10 15 Val Gln Cys Glu Thr Arg Trp Cys Ile Tyr Tyr Asn Ala Asn Trp Glu 20 25 30 Leu Glu Arg Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln 35 40 45 Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr 50 55 60 Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr 65 70 75 80 Asp Arg Gln Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe 85 90 95 Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro 100 105 110 Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro 115 120 125 Thr <210> 5 <211> 330 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(330) <400> 5 gag aca cgg tgg tgc atc tac tac aac gcc aac tgg gag ctg gag cgc 48 Glu Thr Arg Trp Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 1 5 10 15 acc aac cag acc ggc ctg gag cgc tgc gaa ggc gag cag gac aag cgg 96 Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 20 25 30 ctg cac tgc tac gcc tcc tgg cgc aac agc tct ggc acc atc gag ctc 144 Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 35 40 45 gtg aag aag ggc tgc tgg cta gat gac ttc aac tgc tac gat agg cag 192 Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 50 55 60 gag tgt gtg gcc act gag gag aac ccc cag gtg tac ttc tgc tgc tgt 240 Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 65 70 75 80 gag ggc aac ttc tgc aac gag cgc ttc act cat ttg cca gag gct ggg 288 Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 85 90 95 ggc ccg gaa gtc acg tac gag cca ccc ccg aca gcc ccc acc 330 Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 100 105 110 <210> 6 <211> 110 <212> PRT <213> Homo sapiens <400> 6 Glu Thr Arg Trp Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 1 5 10 15 Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 20 25 30 Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 35 40 45 Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 50 55 60 Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 65 70 75 80 Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 85 90 95 Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 100 105 110 <210> 7 <211> 1071 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1071) <400> 7 atg gag ttt ggg ctg agc tgg gtt ttc ctc gtt gct ctt tta aga ggt 48 Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 1 5 10 15 gtc cag tgt gag aca cgg tgg tgc atc tac tac aac gcc aac tgg gag 96 Val Gln Cys Glu Thr Arg Trp Cys Ile Tyr Tyr Asn Ala Asn Trp Glu 20 25 30 ctg gag cgc acc aac cag acc ggc ctg gag cgc tgc gaa ggc gag cag 144 Leu Glu Arg Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln 35 40 45 gac aag cgg ctg cac tgc tac gcc tcc tgg cgc aac agc tct ggc acc 192 Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr 50 55 60 atc gag ctc gtg aag aag ggc tgc tgg cta gat gac ttc aac tgc tac 240 Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr 65 70 75 80 gat agg cag gag tgt gtg gcc act gag gag aac ccc cag gtg tac ttc 288 Asp Arg Gln Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe 85 90 95 tgc tgc tgt gag ggc aac ttc tgc aac gag cgc ttc act cat ttg cca 336 Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro 100 105 110 gag gct ggg ggc ccg gaa gtc acg tac gag cca ccc ccg aca gcc ccc 384 Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro 115 120 125 acc gga ggg gga gga tct gtc gag tgc cca ccg tgc cca gca cca cct 432 Thr Gly Gly Gly Gly Ser Val Glu Cys Pro Pro Cys Pro Ala Pro Pro 130 135 140 gtg gca gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc 480 Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 145 150 155 160 ctc atg atc tcc cgg acc cct gag gtc acg tgc gtg gtg gtg gac gtg 528 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 165 170 175 agc cac gaa gac ccc gag gtc cag ttc aac tgg tac gtg gac ggc gtg 576 Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 180 185 190 gag gtg cat aat gcc aag aca aag cca cgg gag gag cag ttc aac agc 624 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 195 200 205 acg ttc cgt gtg gtc agc gtc ctc acc gtt gtg cac cag gac tgg ctg 672 Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu 210 215 220 aac ggc aag gag tac aag tgc aag gtc tcc aac aaa ggc ctc cca gcc 720 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala 225 230 235 240 ccc atc gag aaa acc atc tcc aaa acc aaa ggg cag ccc cga gaa cca 768 Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro 245 250 255 cag gtg tac acc ctg ccc cca tcc cgg gag gag atg acc aag aac cag 816 Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 260 265 270 gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc gcc 864 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 275 280 285 gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac aag acc aca 912 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 290 295 300 cct ccc atg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag ctc 960 Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 305 310 315 320 acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc 1008 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 325 330 335 gtg atg cat gag gct ctg cac aac cac tac acg cag aag agc ctc tcc 1056 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 340 345 350 ctg tct ccg ggt aaa 1071 Leu Ser Pro Gly Lys 355 <210> 8 <211> 357 <212> PRT <213> Homo sapiens <400> 8 Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 1 5 10 15 Val Gln Cys Glu Thr Arg Trp Cys Ile Tyr Tyr Asn Ala Asn Trp Glu 20 25 30 Leu Glu Arg Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln 35 40 45 Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr 50 55 60 Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr 65 70 75 80 Asp Arg Gln Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe 85 90 95 Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro 100 105 110 Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro 115 120 125 Thr Gly Gly Gly Gly Ser Val Glu Cys Pro Pro Cys Pro Ala Pro Pro 130 135 140 Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 145 150 155 160 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 165 170 175 Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 180 185 190 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 195 200 205 Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu 210 215 220 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala 225 230 235 240 Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro 245 250 255 Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 260 265 270 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 275 280 285 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 290 295 300 Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 305 310 315 320 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 325 330 335 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 340 345 350 Leu Ser Pro Gly Lys 355 <210> 9 <211> 1014 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1014) <400> 9 gag aca cgg tgg tgc atc tac tac aac gcc aac tgg gag ctg gag cgc 48 Glu Thr Arg Trp Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 1 5 10 15 acc aac cag acc ggc ctg gag cgc tgc gaa ggc gag cag gac aag cgg 96 Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 20 25 30 ctg cac tgc tac gcc tcc tgg cgc aac agc tct ggc acc atc gag ctc 144 Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 35 40 45 gtg aag aag ggc tgc tgg cta gat gac ttc aac tgc tac gat agg cag 192 Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 50 55 60 gag tgt gtg gcc act gag gag aac ccc cag gtg tac ttc tgc tgc tgt 240 Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 65 70 75 80 gag ggc aac ttc tgc aac gag cgc ttc act cat ttg cca gag gct ggg 288 Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 85 90 95 ggc ccg gaa gtc acg tac gag cca ccc ccg aca gcc ccc acc gga ggg 336 Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr Gly Gly 100 105 110 gga gga tct gtc gag tgc cca ccg tgc cca gca cca cct gtg gca gga 384 Gly Gly Ser Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 115 120 125 ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc ctc atg atc 432 Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 130 135 140 tcc cgg acc cct gag gtc acg tgc gtg gtg gtg gac gtg agc cac gaa 480 Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 145 150 155 160 gac ccc gag gtc cag ttc aac tgg tac gtg gac ggc gtg gag gtg cat 528 Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 165 170 175 aat gcc aag aca aag cca cgg gag gag cag ttc aac agc acg ttc cgt 576 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 180 185 190 gtg gtc agc gtc ctc acc gtt gtg cac cag gac tgg ctg aac ggc aag 624 Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys 195 200 205 gag tac aag tgc aag gtc tcc aac aaa ggc ctc cca gcc ccc atc gag 672 Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu 210 215 220 aaa acc atc tcc aaa acc aaa ggg cag ccc cga gaa cca cag gtg tac 720 Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 225 230 235 240 acc ctg ccc cca tcc cgg gag gag atg acc aag aac cag gtc agc ctg 768 Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 245 250 255 acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc gcc gtg gag tgg 816 Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 260 265 270 gag agc aat ggg cag ccg gag aac aac tac aag acc aca cct ccc atg 864 Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met 275 280 285 ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag ctc acc gtg gac 912 Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 290 295 300 aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc gtg atg cat 960 Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 305 310 315 320 gag gct ctg cac aac cac tac acg cag aag agc ctc tcc ctg tct ccg 1008 Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 325 330 335 ggt aaa 1014 Gly Lys <210> 10 <211> 338 <212> PRT <213> Homo sapiens <400> 10 Glu Thr Arg Trp Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 1 5 10 15 Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 20 25 30 Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 35 40 45 Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 50 55 60 Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 65 70 75 80 Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 85 90 95 Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr Gly Gly 100 105 110 Gly Gly Ser Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 115 120 125 Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 130 135 140 Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 145 150 155 160 Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 165 170 175 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 180 185 190 Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys 195 200 205 Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu 210 215 220 Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 225 230 235 240 Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 245 250 255 Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 260 265 270 Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met 275 280 285 Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 290 295 300 Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 305 310 315 320 Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 325 330 335 Gly Lys <210> 11 <211> 387 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(387) <400> 11 atg gag ttt ggg ctg agc tgg gtt ttc ctc gtt gct ctt tta aga ggt 48 Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 1 5 10 15 gtc cag tgt gag aca cgg tac tgc atc tac tac aac gcc aac tgg gag 96 Val Gln Cys Glu Thr Arg Tyr Cys Ile Tyr Tyr Asn Ala Asn Trp Glu 20 25 30 ctg gag cgc acc aac cag acc ggc ctg gag cgc tgc gaa ggc gag cag 144 Leu Glu Arg Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln 35 40 45 gac aag cgg ctg cac tgc tac gcc tcc tgg cgc aac agc tct ggc acc 192 Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr 50 55 60 atc gag ctc gtg aag aag ggc tgc tgg cta gat gac ttc aac tgc tac 240 Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr 65 70 75 80 gat agg cag gag tgt gtg gcc act gag gag aac ccc cag gtg tac ttc 288 Asp Arg Gln Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe 85 90 95 tgc tgc tgt gag ggc aac ttc tgc aac gag cgc ttc act cat ttg cca 336 Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro 100 105 110 gag gct ggg ggc ccg gaa gtc acg tac gag cca ccc ccg aca gcc ccc 384 Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro 115 120 125 acc 387 Thr <210> 12 <211> 129 <212> PRT <213> Homo sapiens <400> 12 Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 1 5 10 15 Val Gln Cys Glu Thr Arg Tyr Cys Ile Tyr Tyr Asn Ala Asn Trp Glu 20 25 30 Leu Glu Arg Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln 35 40 45 Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr 50 55 60 Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr 65 70 75 80 Asp Arg Gln Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe 85 90 95 Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro 100 105 110 Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro 115 120 125 Thr <210> 13 <211> 330 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(330) <400> 13 gag aca cgg tac tgc atc tac tac aac gcc aac tgg gag ctg gag cgc 48 Glu Thr Arg Tyr Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 1 5 10 15 acc aac cag acc ggc ctg gag cgc tgc gaa ggc gag cag gac aag cgg 96 Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 20 25 30 ctg cac tgc tac gcc tcc tgg cgc aac agc tct ggc acc atc gag ctc 144 Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 35 40 45 gtg aag aag ggc tgc tgg cta gat gac ttc aac tgc tac gat agg cag 192 Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 50 55 60 gag tgt gtg gcc act gag gag aac ccc cag gtg tac ttc tgc tgc tgt 240 Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 65 70 75 80 gag ggc aac ttc tgc aac gag cgc ttc act cat ttg cca gag gct ggg 288 Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 85 90 95 ggc ccg gaa gtc acg tac gag cca ccc ccg aca gcc ccc acc 330 Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 100 105 110 <210> 14 <211> 110 <212> PRT <213> Homo sapiens <400> 14 Glu Thr Arg Tyr Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 1 5 10 15 Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 20 25 30 Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 35 40 45 Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 50 55 60 Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 65 70 75 80 Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 85 90 95 Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 100 105 110 <210> 15 <211> 1071 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1071) <400> 15 atg gag ttt ggg ctg agc tgg gtt ttc ctc gtt gct ctt tta aga ggt 48 Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 1 5 10 15 gtc cag tgt gag aca cgg tac tgc atc tac tac aac gcc aac tgg gag 96 Val Gln Cys Glu Thr Arg Tyr Cys Ile Tyr Tyr Asn Ala Asn Trp Glu 20 25 30 ctg gag cgc acc aac cag acc ggc ctg gag cgc tgc gaa ggc gag cag 144 Leu Glu Arg Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln 35 40 45 gac aag cgg ctg cac tgc tac gcc tcc tgg cgc aac agc tct ggc acc 192 Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr 50 55 60 atc gag ctc gtg aag aag ggc tgc tgg cta gat gac ttc aac tgc tac 240 Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr 65 70 75 80 gat agg cag gag tgt gtg gcc act gag gag aac ccc cag gtg tac ttc 288 Asp Arg Gln Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe 85 90 95 tgc tgc tgt gag ggc aac ttc tgc aac gag cgc ttc act cat ttg cca 336 Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro 100 105 110 gag gct ggg ggc ccg gaa gtc acg tac gag cca ccc ccg aca gcc ccc 384 Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro 115 120 125 acc gga ggg gga gga tct gtc gag tgc cca ccg tgc cca gca cca cct 432 Thr Gly Gly Gly Gly Ser Val Glu Cys Pro Pro Cys Pro Ala Pro Pro 130 135 140 gtg gca gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc 480 Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 145 150 155 160 ctc atg atc tcc cgg acc cct gag gtc acg tgc gtg gtg gtg gac gtg 528 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 165 170 175 agc cac gaa gac ccc gag gtc cag ttc aac tgg tac gtg gac ggc gtg 576 Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 180 185 190 gag gtg cat aat gcc aag aca aag cca cgg gag gag cag ttc aac agc 624 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 195 200 205 acg ttc cgt gtg gtc agc gtc ctc acc gtt gtg cac cag gac tgg ctg 672 Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu 210 215 220 aac ggc aag gag tac aag tgc aag gtc tcc aac aaa ggc ctc cca gcc 720 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala 225 230 235 240 ccc atc gag aaa acc atc tcc aaa acc aaa ggg cag ccc cga gaa cca 768 Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro 245 250 255 cag gtg tac acc ctg ccc cca tcc cgg gag gag atg acc aag aac cag 816 Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 260 265 270 gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc gcc 864 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 275 280 285 gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac aag acc aca 912 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 290 295 300 cct ccc atg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag ctc 960 Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 305 310 315 320 acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc 1008 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 325 330 335 gtg atg cat gag gct ctg cac aac cac tac acg cag aag agc ctc tcc 1056 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 340 345 350 ctg tct ccg ggt aaa 1071 Leu Ser Pro Gly Lys 355 <210> 16 <211> 357 <212> PRT <213> Homo sapiens <400> 16 Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 1 5 10 15 Val Gln Cys Glu Thr Arg Tyr Cys Ile Tyr Tyr Asn Ala Asn Trp Glu 20 25 30 Leu Glu Arg Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln 35 40 45 Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr 50 55 60 Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr 65 70 75 80 Asp Arg Gln Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe 85 90 95 Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro 100 105 110 Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro 115 120 125 Thr Gly Gly Gly Gly Ser Val Glu Cys Pro Pro Cys Pro Ala Pro Pro 130 135 140 Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 145 150 155 160 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 165 170 175 Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 180 185 190 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 195 200 205 Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu 210 215 220 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala 225 230 235 240 Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro 245 250 255 Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 260 265 270 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 275 280 285 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 290 295 300 Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 305 310 315 320 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 325 330 335 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 340 345 350 Leu Ser Pro Gly Lys 355 <210> 17 <211> 1014 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1014) <400> 17 gag aca cgg tac tgc atc tac tac aac gcc aac tgg gag ctg gag cgc 48 Glu Thr Arg Tyr Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 1 5 10 15 acc aac cag acc ggc ctg gag cgc tgc gaa ggc gag cag gac aag cgg 96 Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 20 25 30 ctg cac tgc tac gcc tcc tgg cgc aac agc tct ggc acc atc gag ctc 144 Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 35 40 45 gtg aag aag ggc tgc tgg cta gat gac ttc aac tgc tac gat agg cag 192 Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 50 55 60 gag tgt gtg gcc act gag gag aac ccc cag gtg tac ttc tgc tgc tgt 240 Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 65 70 75 80 gag ggc aac ttc tgc aac gag cgc ttc act cat ttg cca gag gct ggg 288 Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 85 90 95 ggc ccg gaa gtc acg tac gag cca ccc ccg aca gcc ccc acc gga ggg 336 Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr Gly Gly 100 105 110 gga gga tct gtc gag tgc cca ccg tgc cca gca cca cct gtg gca gga 384 Gly Gly Ser Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 115 120 125 ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc ctc atg atc 432 Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 130 135 140 tcc cgg acc cct gag gtc acg tgc gtg gtg gtg gac gtg agc cac gaa 480 Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 145 150 155 160 gac ccc gag gtc cag ttc aac tgg tac gtg gac ggc gtg gag gtg cat 528 Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 165 170 175 aat gcc aag aca aag cca cgg gag gag cag ttc aac agc acg ttc cgt 576 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 180 185 190 gtg gtc agc gtc ctc acc gtt gtg cac cag gac tgg ctg aac ggc aag 624 Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys 195 200 205 gag tac aag tgc aag gtc tcc aac aaa ggc ctc cca gcc ccc atc gag 672 Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu 210 215 220 aaa acc atc tcc aaa acc aaa ggg cag ccc cga gaa cca cag gtg tac 720 Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 225 230 235 240 acc ctg ccc cca tcc cgg gag gag atg acc aag aac cag gtc agc ctg 768 Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 245 250 255 acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc gcc gtg gag tgg 816 Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 260 265 270 gag agc aat ggg cag ccg gag aac aac tac aag acc aca cct ccc atg 864 Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met 275 280 285 ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag ctc acc gtg gac 912 Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 290 295 300 aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc gtg atg cat 960 Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 305 310 315 320 gag gct ctg cac aac cac tac acg cag aag agc ctc tcc ctg tct ccg 1008 Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 325 330 335 ggt aaa 1014 Gly Lys <210> 18 <211> 338 <212> PRT <213> Homo sapiens <400> 18 Glu Thr Arg Tyr Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 1 5 10 15 Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 20 25 30 Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 35 40 45 Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 50 55 60 Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 65 70 75 80 Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 85 90 95 Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr Gly Gly 100 105 110 Gly Gly Ser Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 115 120 125 Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 130 135 140 Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 145 150 155 160 Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 165 170 175 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 180 185 190 Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys 195 200 205 Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu 210 215 220 Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 225 230 235 240 Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 245 250 255 Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 260 265 270 Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met 275 280 285 Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 290 295 300 Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 305 310 315 320 Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 325 330 335 Gly Lys <210> 19 <211> 110 <212> PRT <213> Homo sapiens <400> 19 Glu Thr Arg Trp Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 1 5 10 15 Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 20 25 30 Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 35 40 45 Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 50 55 60 Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 65 70 75 80 Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 85 90 95 Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 100 105 110 <210> 20 <211> 1014 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1014) <400> 20 gag aca cgg tgg tgc atc tac tac aac gcc aac tgg gag ctg gag cgc 48 Glu Thr Arg Trp Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 1 5 10 15 acc aac cag agc ggc ctg gag cgc tgc gaa ggc gag cag gac aag cgg 96 Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 20 25 30 ctg cac tgc tac gcc tcc tgg cgc aac agc tct ggc acc atc gag ctc 144 Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 35 40 45 gtg aag aag ggc tgc tgg cta gat gac ttc aac tgc tac gat agg cag 192 Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 50 55 60 gag tgt gtg gcc act gag gag aac ccc cag gtg tac ttc tgc tgc tgt 240 Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 65 70 75 80 gag ggc aac ttc tgc aac gag cgc ttc act cat ttg cca gag gct ggg 288 Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 85 90 95 ggc ccg gaa gtc acg tac gag cca ccc ccg aca gcc ccc acc gga gga 336 Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr Gly Gly 100 105 110 gga gga tct gtc gag tgc cca ccg tgc cca gca cca cct gtg gca gga 384 Gly Gly Ser Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 115 120 125 ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc ctc atg atc 432 Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 130 135 140 tcc cgg acc cct gag gtc acg tgc gtg gtg gtg gac gtg agc cac gaa 480 Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 145 150 155 160 gac ccc gag gtc cag ttc aac tgg tac gtg gac ggc gtg gag gtg cat 528 Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 165 170 175 aat gcc aag aca aag cca cgg gag gag cag ttc aac agc acg ttc cgt 576 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 180 185 190 gtg gtc agc gtc ctc acc gtt gtg cac cag gac tgg ctg aac ggc aag 624 Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys 195 200 205 gag tac aag tgc aag gtc tcc aac aaa ggc ctc cca gcc ccc atc gag 672 Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu 210 215 220 aaa acc atc tcc aaa acc aaa ggg cag ccc cga gaa cca cag gtg tac 720 Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 225 230 235 240 acc ctg ccc cca tcc cgg gag gag atg acc aag aac cag gtc agc ctg 768 Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 245 250 255 acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc gcc gtg gag tgg 816 Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 260 265 270 gag agc aat ggg cag ccg gag aac aac tac aag acc aca cct ccc atg 864 Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met 275 280 285 ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag ctc acc gtg gac 912 Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 290 295 300 aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc gtg atg cat 960 Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 305 310 315 320 gag gct ctg cac aac cac tac acg cag aag agc ctc tcc ctg tct ccg 1008 Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 325 330 335 ggt aaa 1014 Gly Lys <210> 21 <211> 338 <212> PRT <213> Homo sapiens <400> 21 Glu Thr Arg Trp Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 1 5 10 15 Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 20 25 30 Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 35 40 45 Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 50 55 60 Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 65 70 75 80 Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 85 90 95 Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr Gly Gly 100 105 110 Gly Gly Ser Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 115 120 125 Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 130 135 140 Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 145 150 155 160 Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 165 170 175 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 180 185 190 Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys 195 200 205 Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu 210 215 220 Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 225 230 235 240 Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 245 250 255 Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 260 265 270 Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met 275 280 285 Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 290 295 300 Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 305 310 315 320 Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 325 330 335 Gly Lys <210> 22 <211> 216 <212> PRT <213> Homo sapiens <400> 22 Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 1 5 10 15 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 20 25 30 Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 35 40 45 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 50 55 60 Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln 65 70 75 80 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 85 90 95 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro 100 105 110 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 115 120 125 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 130 135 140 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 145 150 155 160 Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 165 170 175 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 180 185 190 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 195 200 205 Ser Leu Ser Leu Ser Pro Gly Lys 210 215 <210> 23 <211> 217 <212> PRT <213> Homo sapiens <400> 23 Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 1 5 10 15 Pro Lys Asp Ile Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 20 25 30 Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 35 40 45 Val Gly Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 50 55 60 Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 65 70 75 80 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 85 90 95 Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 100 105 110 Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 115 120 125 Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 130 135 140 Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 145 150 155 160 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 165 170 175 Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 180 185 190 Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 195 200 205 Lys Ser Leu Ser Leu Ser Pro Gly Lys 210 215 <210> 24 <211> 217 <212> PRT <213> Homo sapiens <400> 24 Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 1 5 10 15 Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 20 25 30 Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 35 40 45 Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 50 55 60 Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 65 70 75 80 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 85 90 95 Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 100 105 110 Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 115 120 125 Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 130 135 140 Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 145 150 155 160 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 165 170 175 Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 180 185 190 Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 195 200 205 Lys Ser Leu Ser Leu Ser Leu Gly Lys 210 215 <210> 25 <211> 5 <212> PRT <213> Artificial <220> <223> Linker <400> 25 Gly Gly Gly Gly Ser 1 5 <210> 26 <211> 36 <212> DNA <213> Artificial <220> <223> Hinge linker <220> <221> CDS <222> (1)..(36) <400> 26 gga ggg gga gga tct gtc gag tgc cca ccg tgc cca 36 Gly Gly Gly Gly Ser Val Glu Cys Pro Pro Cys Pro 1 5 10 <210> 27 <211> 12 <212> PRT <213> Artificial <220> <223> Hinge linker <400> 27 Gly Gly Gly Gly Ser Val Glu Cys Pro Pro Cys Pro 1 5 10 <210> 28 <211> 12 <212> PRT <213> Homo sapiens <400> 28 Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 1 5 10 <210> 29 <211> 15 <212> PRT <213> Homo sapiens <400> 29 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 1 5 10 15 <210> 30 <211> 12 <212> PRT <213> Homo sapiens <400> 30 Glu Ser Lys Thr Gly Pro Pro Cys Pro Ser Cys Pro 1 5 10 <210> 31 <211> 18 <212> PRT <213> Homo sapiens <400> 31 Met Thr Ala Pro Trp Val Ala Leu Ala Leu Leu Trp Gly Ser Leu Trp 1 5 10 15 Pro Gly <210> 32 <211> 18 <212> PRT <213> Homo sapiens <400> 32 Met Thr Ala Pro Trp Val Ala Leu Ala Leu Leu Trp Gly Ser Leu Cys 1 5 10 15 Ala Gly <210> 33 <211> 512 <212> PRT <213> Homo sapiens <400> 33 Met Thr Ala Pro Trp Val Ala Leu Ala Leu Leu Trp Gly Ser Leu Cys 1 5 10 15 Ala Gly Ser Gly Arg Gly Glu Ala Glu Thr Arg Glu Cys Ile Tyr Tyr 20 25 30 Asn Ala Asn Trp Glu Leu Glu Arg Thr Asn Gln Ser Gly Leu Glu Arg 35 40 45 Cys Glu Gly Glu Gln Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg 50 55 60 Asn Ser Ser Gly Thr Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp 65 70 75 80 Asp Phe Asn Cys Tyr Asp Arg Gln Glu Cys Val Ala Thr Glu Glu Asn 85 90 95 Pro Gln Val Tyr Phe Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg 100 105 110 Phe Thr His Leu Pro Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro 115 120 125 Pro Pro Thr Ala Pro Thr Leu Leu Thr Val Leu Ala Tyr Ser Leu Leu 130 135 140 Pro Ile Gly Gly Leu Ser Leu Ile Val Leu Leu Ala Phe Trp Met Tyr 145 150 155 160 Arg His Arg Lys Pro Pro Tyr Gly His Val Asp Ile His Glu Asp Pro 165 170 175 Gly Pro Pro Pro Pro Ser Pro Leu Val Gly Leu Lys Pro Leu Gln Leu 180 185 190 Leu Glu Ile Lys Ala Arg Gly Arg Phe Gly Cys Val Trp Lys Ala Gln 195 200 205 Leu Met Asn Asp Phe Val Ala Val Lys Ile Phe Pro Leu Gln Asp Lys 210 215 220 Gln Ser Trp Gln Ser Glu Arg Glu Ile Phe Ser Thr Pro Gly Met Lys 225 230 235 240 His Glu Asn Leu Leu Gln Phe Ile Ala Ala Glu Lys Arg Gly Ser Asn 245 250 255 Leu Glu Val Glu Leu Trp Leu Ile Thr Ala Phe His Asp Lys Gly Ser 260 265 270 Leu Thr Asp Tyr Leu Lys Gly Asn Ile Ile Thr Trp Asn Glu Leu Cys 275 280 285 His Val Ala Glu Thr Met Ser Arg Gly Leu Ser Tyr Leu His Glu Asp 290 295 300 Val Pro Trp Cys Arg Gly Glu Gly His Lys Pro Ser Ile Ala His Arg 305 310 315 320 Asp Phe Lys Ser Lys Asn Val Leu Leu Lys Ser Asp Leu Thr Ala Val 325 330 335 Leu Ala Asp Phe Gly Leu Ala Val Arg Phe Glu Pro Gly Lys Pro Pro 340 345 350 Gly Asp Thr His Gly Gln Val Gly Thr Arg Arg Tyr Met Ala Pro Glu 355 360 365 Val Leu Glu Gly Ala Ile Asn Phe Gln Arg Asp Ala Phe Leu Arg Ile 370 375 380 Asp Met Tyr Ala Met Gly Leu Val Leu Trp Glu Leu Val Ser Arg Cys 385 390 395 400 Lys Ala Ala Asp Gly Pro Val Asp Glu Tyr Met Leu Pro Phe Glu Glu 405 410 415 Glu Ile Gly Gln His Pro Ser Leu Glu Glu Leu Gln Glu Val Val Val 420 425 430 His Lys Lys Met Arg Pro Thr Ile Lys Asp His Trp Leu Lys His Pro 435 440 445 Gly Leu Ala Gln Leu Cys Val Thr Ile Glu Glu Cys Trp Asp His Asp 450 455 460 Ala Glu Ala Arg Leu Ser Ala Gly Cys Val Glu Glu Arg Val Ser Leu 465 470 475 480 Ile Arg Arg Ser Val Asn Gly Thr Thr Ser Asp Cys Leu Val Ser Leu 485 490 495 Val Thr Ser Val Thr Asn Val Asp Leu Pro Pro Lys Glu Ser Ser Ile 500 505 510 <210> 34 <211> 426 <212> PRT <213> Homo sapiens <400> 34 Met Pro Leu Leu Trp Leu Arg Gly Phe Leu Leu Ala Ser Cys Trp Ile 1 5 10 15 Ile Val Arg Ser Ser Pro Thr Pro Gly Ser Glu Gly His Ser Ala Ala 20 25 30 Pro Asp Cys Pro Ser Cys Ala Leu Ala Ala Leu Pro Lys Asp Val Pro 35 40 45 Asn Ser Gln Pro Glu Met Val Glu Ala Val Lys Lys His Ile Leu Asn 50 55 60 Met Leu His Leu Lys Lys Arg Pro Asp Val Thr Gln Pro Val Pro Lys 65 70 75 80 Ala Ala Leu Leu Asn Ala Ile Arg Lys Leu His Val Gly Lys Val Gly 85 90 95 Glu Asn Gly Tyr Val Glu Ile Glu Asp Asp Ile Gly Arg Arg Ala Glu 100 105 110 Met Asn Glu Leu Met Glu Gln Thr Ser Glu Ile Ile Thr Phe Ala Glu 115 120 125 Ser Gly Thr Ala Arg Lys Thr Leu His Phe Glu Ile Ser Lys Glu Gly 130 135 140 Ser Asp Leu Ser Val Val Glu Arg Ala Glu Val Trp Leu Phe Leu Lys 145 150 155 160 Val Pro Lys Ala Asn Arg Thr Arg Thr Lys Val Thr Ile Arg Leu Phe 165 170 175 Gln Gln Gln Lys His Pro Gln Gly Ser Leu Asp Thr Gly Glu Glu Ala 180 185 190 Glu Glu Val Gly Leu Lys Gly Glu Arg Ser Glu Leu Leu Leu Ser Glu 195 200 205 Lys Val Val Asp Ala Arg Lys Ser Thr Trp His Val Phe Pro Val Ser 210 215 220 Ser Ser Ile Gln Arg Leu Leu Asp Gln Gly Lys Ser Ser Leu Asp Val 225 230 235 240 Arg Ile Ala Cys Glu Gln Cys Gln Glu Ser Gly Ala Ser Leu Val Leu 245 250 255 Leu Gly Lys Lys Lys Lys Lys Glu Glu Glu Gly Glu Gly Lys Lys Lys 260 265 270 Gly Gly Gly Glu Gly Gly Ala Gly Ala Asp Glu Glu Lys Glu Gln Ser 275 280 285 His Arg Pro Phe Leu Met Leu Gln Ala Arg Gln Ser Glu Asp His Pro 290 295 300 His Arg Arg Arg Arg Arg Gly Leu Glu Cys Asp Gly Lys Val Asn Ile 305 310 315 320 Cys Cys Lys Lys Gln Phe Phe Val Ser Phe Lys Asp Ile Gly Trp Asn 325 330 335 Asp Trp Ile Ile Ala Pro Ser Gly Tyr His Ala Asn Tyr Cys Glu Gly 340 345 350 Glu Cys Pro Ser His Ile Ala Gly Thr Ser Gly Ser Ser Leu Ser Phe 355 360 365 His Ser Thr Val Ile Asn His Tyr Arg Met Arg Gly His Ser Pro Phe 370 375 380 Ala Asn Leu Lys Ser Cys Cys Val Pro Thr Lys Leu Arg Pro Met Ser 385 390 395 400 Met Leu Tyr Tyr Asp Asp Gly Gln Asn Ile Ile Lys Lys Asp Ile Gln 405 410 415 Asn Met Ile Val Glu Glu Cys Gly Cys Ser 420 425 <210> 35 <211> 375 <212> PRT <213> Homo sapiens <400> 35 Met Gln Lys Leu Gln Leu Cys Val Tyr Ile Tyr Leu Phe Met Leu Ile 1 5 10 15 Val Ala Gly Pro Val Asp Leu Asn Glu Asn Ser Glu Gln Lys Glu Asn 20 25 30 Val Glu Lys Glu Gly Leu Cys Asn Ala Cys Thr Trp Arg Gln Asn Thr 35 40 45 Lys Ser Ser Arg Ile Glu Ala Ile Lys Ile Gln Ile Leu Ser Lys Leu 50 55 60 Arg Leu Glu Thr Ala Pro Asn Ile Ser Lys Asp Val Ile Arg Gln Leu 65 70 75 80 Leu Pro Lys Ala Pro Pro Leu Arg Glu Leu Ile Asp Gln Tyr Asp Val 85 90 95 Gln Arg Asp Asp Ser Ser Asp Gly Ser Leu Glu Asp Asp Asp Tyr His 100 105 110 Ala Thr Thr Glu Thr Ile Ile Thr Met Pro Thr Glu Ser Asp Phe Leu 115 120 125 Met Gln Val Asp Gly Lys Pro Lys Cys Cys Phe Phe Lys Phe Ser Ser 130 135 140 Lys Ile Gln Tyr Asn Lys Val Val Lys Ala Gln Leu Trp Ile Tyr Leu 145 150 155 160 Arg Pro Val Glu Thr Pro Thr Thr Val Phe Val Gln Ile Leu Arg Leu 165 170 175 Ile Lys Pro Met Lys Asp Gly Thr Arg Tyr Thr Gly Ile Arg Ser Leu 180 185 190 Lys Leu Asp Met Asn Pro Gly Thr Gly Ile Trp Gln Ser Ile Asp Val 195 200 205 Lys Thr Val Leu Gln Asn Trp Leu Lys Gln Pro Glu Ser Asn Leu Gly 210 215 220 Ile Glu Ile Lys Ala Leu Asp Glu Asn Gly His Asp Leu Ala Val Thr 225 230 235 240 Phe Pro Gly Pro Gly Glu Asp Gly Leu Asn Pro Phe Leu Glu Val Lys 245 250 255 Val Thr Asp Thr Pro Lys Arg Ser Arg Arg Asp Phe Gly Leu Asp Cys 260 265 270 Asp Glu His Ser Thr Glu Ser Arg Cys Cys Arg Tyr Pro Leu Thr Val 275 280 285 Asp Phe Glu Ala Phe Gly Trp Asp Trp Ile Ile Ala Pro Lys Arg Tyr 290 295 300 Lys Ala Asn Tyr Cys Ser Gly Glu Cys Glu Phe Val Phe Leu Gln Lys 305 310 315 320 Tyr Pro His Thr His Leu Val His Gln Ala Asn Pro Arg Gly Ser Ala 325 330 335 Gly Pro Cys Cys Thr Pro Thr Lys Met Ser Pro Ile Asn Met Leu Tyr 340 345 350 Phe Asn Gly Lys Glu Gln Ile Ile Tyr Gly Lys Ile Pro Ala Met Val 355 360 365 Val Asp Arg Cys Gly Cys Ser 370 375 <210> 36 <211> 217 <212> PRT <213> Homo sapiens <400> 36 Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 1 5 10 15 Pro Lys Asp Ile Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 20 25 30 Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 35 40 45 Val Gly Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 50 55 60 Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 65 70 75 80 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 85 90 95 Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 100 105 110 Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 115 120 125 Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 130 135 140 Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 145 150 155 160 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 165 170 175 Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 180 185 190 Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 195 200 205 Lys Ser Leu Ser Leu Ser Pro Gly Lys 210 215 <210> 37 <211> 48 <212> DNA <213> Artificial <220> <223> Hinge linker <220> <221> CDS <222> (1)..(48) <400> 37 gga ggg gga gga tct gag cgc aaa tgt tgt gtc gag tgc cca ccg tgc 48 Gly Gly Gly Gly Ser Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys 1 5 10 15 <210> 38 <211> 16 <212> PRT <213> Artificial <220> <223> Hinge linker <400> 38 Gly Gly Gly Gly Ser Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys 1 5 10 15 <210> 39 <211> 42 <212> DNA <213> Artificial <220> <223> Hinge linker <220> <221> CDS <222> (1)..(42) <400> 39 gga ggg gga gga tct ggt gga ggt ggt tca ggt cca ccg tgc 42 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Pro Pro Cys 1 5 10 <210> 40 <211> 14 <212> PRT <213> Artificial <220> <223> Hinge linker <400> 40 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Pro Pro Cys 1 5 10 <210> 41 <211> 42 <212> DNA <213> Artificial <220> <223> Hinge linker <220> <221> CDS <222> (1)..(42) <400> 41 gga ggg gga gga tct ggt gga ggt ggt tca ggt cca ccg gga 42 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Pro Pro Gly 1 5 10 <210> 42 <211> 14 <212> PRT <213> Artificial <220> <223> Hinge linker <400> 42 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Pro Pro Gly 1 5 10 <210> 43 <211> 54 <212> DNA <213> Artificial <220> <223> Hinge linker <220> <221> CDS <222> (1)..(54) <400> 43 gga ggg gga gga tct gag cgc aaa tgt cca cct tgt gtc gag tgc cca 48 Gly Gly Gly Gly Ser Glu Arg Lys Cys Pro Pro Cys Val Glu Cys Pro 1 5 10 15 ccg tgc 54 Pro Cys <210> 44 <211> 18 <212> PRT <213> Artificial <220> <223> Hinge linker <400> 44 Gly Gly Gly Gly Ser Glu Arg Lys Cys Pro Pro Cys Val Glu Cys Pro 1 5 10 15 Pro Cys <210> 45 <211> 14 <212> PRT <213> Artificial <220> <223> Hinge linker <400> 45 Gly Pro Ala Ser Gly Gly Pro Ala Ser Gly Pro Pro Cys Pro 1 5 10 <210> 46 <211> 21 <212> PRT <213> Artificial <220> <223> Hinge linker <400> 46 Gly Pro Ala Ser Gly Gly Pro Ala Ser Gly Cys Pro Pro Cys Val Glu 1 5 10 15 Cys Pro Pro Cys Pro 20 <210> 47 <211> 217 <212> PRT <213> Homo sapiens <400> 47 Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 1 5 10 15 Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 20 25 30 Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 35 40 45 Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 50 55 60 Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 65 70 75 80 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 85 90 95 Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 100 105 110 Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 115 120 125 Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 130 135 140 Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 145 150 155 160 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 165 170 175 Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 180 185 190 Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 195 200 205 Lys Ser Leu Ser Leu Ser Pro Gly Lys 210 215 <210> 48 <211> 16 <212> PRT <213> Artificial <220> <223> Hinge linker <400> 48 Gly Gly Gly Gly Ser Val Asp Lys Thr His Thr Cys Pro Pro Cys Pro 1 5 10 15 <210> 49 <211> 16 <212> PRT <213> Artificial <220> <223> Hinge linker <400> 49 Gly Gly Gly Gly Ser Val Asp Lys Thr His Thr Gly Pro Pro Cys Pro 1 5 10 15 <210> 50 <211> 21 <212> PRT <213> Artificial <220> <223> Hinge linker <400> 50 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Val Asp Lys Thr His Thr 1 5 10 15 Gly Pro Pro Cys Pro 20 <210> 51 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <400> 51 Gly Gly Gly Gly Gly 1 5 <210> 52 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <400> 52 Gly Gly Gly Gly Gly Gly Gly Gly 1 5 <210> 53 <211> 300 <212> DNA <213> Homo sapiens <400> 53 gagacacggt ggtgcatcta ctacaacgcc aactgggagc tggagcgcac caaccagacc 60 ggcctggagc gctgcgaagg cgagcaggac aagcggctgc actgctacgc ctcctggcgc 120 aacagctctg gcaccatcga gctcgtgaag aagggctgct ggctagatga cttcaactgc 180 tacgataggc aggagtgtgt ggccactgag gagaaccccc aggtgtactt ctgctgctgt 240 gagggcaact tctgcaacga gcgcttcact catttgccag aggctggggg cccggaagtc 300