LISTADO DE SECUENCIAS <110> Firmenich S.A. <120> DRIMENOL SYNTHASES II <130> P224360WO/ICA <140> PCT/EP2015/059988 <141> 2015-05-06 <150> PCT/CN2014/076890 <151> 2014-05-06 <160> 15 <170> PatentIn version 3.5 <210> 1 <211> 1680 <212> DNA <213> Drimys lanceolata <400> 1 atggatctta ttaatccctc cccagcggct tccaccctcc ctctcccagt tgatggagat 60 tcagaagttg ttaggcgatc tgccgggttt catccgacta tctggggcga tcacttcctc 120 tcctacaagc ccgatccaaa gaaaatagat gcatggaata aaagggttga agagctgaag 180 gaagaagtga agaagatatt aagcaatgca aaagggacgg tggaagagct gaatttgatt 240 gatgatctcg tacaccttgg gattagttat cattttgaga aggagattga tgatgctcta 300 caacacatct ttgataccca tcttgatgat tttcctaagg atgatctata tgtcgccgct 360 ctccgatttg gcgtcttaag gaaacagggg caccgtgttt ctccagatgt attcaaaaaa 420 ttcaaagatg agcaggggaa tttcaaggca gagttgagca ccgatgcgaa aggtttgcta 480 tgtttaaatg atgtggctta tctcagcaca agaggggaag atatcttgga tgaagccatt 540 cctttcactg aggagcacct taggtcttgt attagccatg tagattctca tatggcagca 600 aaaattgaac attctctcga gcttcccctt catcatcgca taccaaggct agagaacagg 660 cactacatct cagtctatga aggagacaag gaaaggaacg aagttgtcct tgagcttgcc 720 aatttagatt tcaatctgat tcaaatcttg caccaaagag agctgagaga catcacaatg 780 tggtggaagg agattgacct tgcagcaaag ctgcctttta ttagggatag gttggtggag 840 tgctactact ggatcatggg ggtctatttt gaaccaatat actcgagggc tagggttttt 900 tccaccaaaa tgacaatgtt ggtctcagtt gtggacgaca tatatgatgt gtatgctacc 960 gaggatgagc ttcaactatt cactgatgcc atctataggt gggatgctga tgacattgat 1020 cagctgcctc agtacttgaa agatgctttt atggtactct acaacactgt gaagactcta 1080 gaagaagaac ttgaaccaga aggaaactct tatcgtggat tctatgtaaa agatgcaatg 1140 aaggttttgg caagggatta ctttgtggag cacaaatggt ataacagaaa aattgtgcca 1200 tccgtagagg aatacttgaa aatttcttgc atcagtgtgg ccgttcatat ggctacagtt 1260 cactgtattg ctgggatgta tgaaattgca accaaagagg cattcgaatg gttgatgact 1320 gagcccaaac ttgttattga tgcatctctg attggtcgtc tccttgatga catgcagtcc 1380 acctcgtttg agcaacagag aggccacgtg tcatcagcag tacagtgtta catggctgaa 1440 tatggtgtaa cagcggaaga agcatgtgaa aagctccgag atatggctgc aattgcttgg 1500 aaagatgtga acgaggcatg ccttaggccc acggttttcc ctatgcctat ccttttgcct 1560 tctatcaact tggcacgtgt ggcagaagtc atctacctac gtggagatgg atacacgcac 1620 gctgggggtg agaccaagaa acacatcacg gccatgcttg ttaagccaat tgaagtctga 1680 <210> 2 <211> 559 <212> PRT <213> Drimys lanceolata <400> 2 Met Asp Leu Ile Asn Pro Ser Pro Ala Ala Ser Thr Leu Pro Leu Pro 1 5 10 15 Val Asp Gly Asp Ser Glu Val Val Arg Arg Ser Ala Gly Phe His Pro 20 25 30 Thr Ile Trp Gly Asp His Phe Leu Ser Tyr Lys Pro Asp Pro Lys Lys 35 40 45 Ile Asp Ala Trp Asn Lys Arg Val Glu Glu Leu Lys Glu Glu Val Lys 50 55 60 Lys Ile Leu Ser Asn Ala Lys Gly Thr Val Glu Glu Leu Asn Leu Ile 65 70 75 80 Asp Asp Leu Val His Leu Gly Ile Ser Tyr His Phe Glu Lys Glu Ile 85 90 95 Asp Asp Ala Leu Gln His Ile Phe Asp Thr His Leu Asp Asp Phe Pro 100 105 110 Lys Asp Asp Leu Tyr Val Ala Ala Leu Arg Phe Gly Val Leu Arg Lys 115 120 125 Gln Gly His Arg Val Ser Pro Asp Val Phe Lys Lys Phe Lys Asp Glu 130 135 140 Gln Gly Asn Phe Lys Ala Glu Leu Ser Thr Asp Ala Lys Gly Leu Leu 145 150 155 160 Cys Leu Asn Asp Val Ala Tyr Leu Ser Thr Arg Gly Glu Asp Ile Leu 165 170 175 Asp Glu Ala Ile Pro Phe Thr Glu Glu His Leu Arg Ser Cys Ile Ser 180 185 190 His Val Asp Ser His Met Ala Ala Lys Ile Glu His Ser Leu Glu Leu 195 200 205 Pro Leu His His Arg Ile Pro Arg Leu Glu Asn Arg His Tyr Ile Ser 210 215 220 Val Tyr Glu Gly Asp Lys Glu Arg Asn Glu Val Val Leu Glu Leu Ala 225 230 235 240 Asn Leu Asp Phe Asn Leu Ile Gln Ile Leu His Gln Arg Glu Leu Arg 245 250 255 Asp Ile Thr Met Trp Trp Lys Glu Ile Asp Leu Ala Ala Lys Leu Pro 260 265 270 Phe Ile Arg Asp Arg Leu Val Glu Cys Tyr Tyr Trp Ile Met Gly Val 275 280 285 Tyr Phe Glu Pro Ile Tyr Ser Arg Ala Arg Val Phe Ser Thr Lys Met 290 295 300 Thr Met Leu Val Ser Val Val Asp Asp Ile Tyr Asp Val Tyr Ala Thr 305 310 315 320 Glu Asp Glu Leu Gln Leu Phe Thr Asp Ala Ile Tyr Arg Trp Asp Ala 325 330 335 Asp Asp Ile Asp Gln Leu Pro Gln Tyr Leu Lys Asp Ala Phe Met Val 340 345 350 Leu Tyr Asn Thr Val Lys Thr Leu Glu Glu Glu Leu Glu Pro Glu Gly 355 360 365 Asn Ser Tyr Arg Gly Phe Tyr Val Lys Asp Ala Met Lys Val Leu Ala 370 375 380 Arg Asp Tyr Phe Val Glu His Lys Trp Tyr Asn Arg Lys Ile Val Pro 385 390 395 400 Ser Val Glu Glu Tyr Leu Lys Ile Ser Cys Ile Ser Val Ala Val His 405 410 415 Met Ala Thr Val His Cys Ile Ala Gly Met Tyr Glu Ile Ala Thr Lys 420 425 430 Glu Ala Phe Glu Trp Leu Met Thr Glu Pro Lys Leu Val Ile Asp Ala 435 440 445 Ser Leu Ile Gly Arg Leu Leu Asp Asp Met Gln Ser Thr Ser Phe Glu 450 455 460 Gln Gln Arg Gly His Val Ser Ser Ala Val Gln Cys Tyr Met Ala Glu 465 470 475 480 Tyr Gly Val Thr Ala Glu Glu Ala Cys Glu Lys Leu Arg Asp Met Ala 485 490 495 Ala Ile Ala Trp Lys Asp Val Asn Glu Ala Cys Leu Arg Pro Thr Val 500 505 510 Phe Pro Met Pro Ile Leu Leu Pro Ser Ile Asn Leu Ala Arg Val Ala 515 520 525 Glu Val Ile Tyr Leu Arg Gly Asp Gly Tyr Thr His Ala Gly Gly Glu 530 535 540 Thr Lys Lys His Ile Thr Ala Met Leu Val Lys Pro Ile Glu Val 545 550 555 <210> 3 <211> 1680 <212> DNA <213> Artificial Sequence <220> <223> Codon optimized DNA sequence of DlTps589 from D. lanceolata <400> 3 atggacctga ttaacccgag ccctgctgca tccaccctgc cactgccagt cgatggtgat 60 agcgaagttg tgcgccgtag cgcgggtttc catccgacca tctggggtga ccactttctg 120 tcttataagc cggacccgaa aaagattgat gcgtggaaca agcgtgttga ggaactgaaa 180 gaagaggtca aaaagatttt gagcaatgcg aaaggcacgg ttgaggaact gaatttgatt 240 gacgacctgg tacacctggg tattagctat cactttgaga aagaaatcga cgacgcgctg 300 cagcatatct tcgatacgca cctggatgat ttcccgaaag atgacctcta cgtggctgcg 360 ctgcgttttg gcgtcctgcg taagcaaggc catcgtgtca gcccggacgt ctttaagaaa 420 ttcaaagacg agcaaggcaa cttcaaagcg gagctgtcaa ccgatgcaaa gggcctgttg 480 tgcctgaacg atgtggcgta cctgagcacc cgtggtgagg atatcctgga cgaagcgatc 540 ccgttcacgg aagaacattt gcgctcgtgc attagccacg ttgatagcca catggcagcg 600 aagattgagc actctctgga gctgccgctg caccatcgca ttccgcgttt agagaatcgc 660 cattacatct ccgtgtacga gggtgacaaa gagcgtaatg aagtcgttct ggagttggct 720 aacttggact ttaatcttat ccagatcctg caccagcgcg agctgcgcga catcacgatg 780 tggtggaaag aaattgatct ggccgcaaag ctgccgttta ttcgtgaccg tctggtggag 840 tgttactatt ggattatggg cgtgtacttc gagccgatct acagccgtgc gcgcgtgttt 900 agcaccaaga tgaccatgct ggttagcgtg gtggatgaca tctatgatgt ctacgctacg 960 gaagatgagt tgcagctgtt taccgacgcc atttacagat gggacgccga tgacattgat 1020 caactgccgc aatatctgaa agacgccttt atggttctgt acaacaccgt caaaaccctg 1080 gaagaagaac tggagccgga aggtaactct tatcgtggtt tctacgttaa agatgcgatg 1140 aaagttctgg cgcgtgacta tttcgttgag cataagtggt acaatcgtaa gatcgtcccg 1200 tccgttgaag agtacttgaa gattagctgt atcagcgtcg cagtccacat ggcgaccgtg 1260 cactgtatcg ccggcatgta tgagatcgcc acgaaagaag cattcgagtg gctgatgacc 1320 gagccgaaac tggtgattga cgcaagcctg attggtcgcc tgctggacga tatgcagagc 1380 acgagctttg agcagcagcg cggtcatgtt agctccgcag ttcaatgcta catggctgag 1440 tacggtgtga ctgccgaaga agcatgcgag aagctgcgtg atatggcggc cattgcgtgg 1500 aaagatgtga atgaagcatg cctgcgcccg accgttttcc cgatgccgat tttactgcct 1560 agcatcaacc tggcacgtgt ggcggaagtt atctatctgc gtggcgacgg ttatacgcac 1620 gcgggtggtg agactaagaa gcacatcacc gcgatgctgg tcaagccgat cgaagtgtaa 1680 <210> 4 <211> 1656 <212> DNA <213> Drimys winteri <400> 4 atggcttcca ccctccctct cccagcttat ggagattcag aagttgttag gcgatctgcc 60 gggtttcatc cgacgatctg gggcgatcac ttcctctcct acaagcctga tccaacgaaa 120 atagatgaat ggaataaaag ggttgaagag ctgaaggaag aagtgaagaa gatattaagc 180 aatgcaaaag ggacagtgga agagctgaat ttgcttgatg atctcgtaca ccttgggatt 240 agttatcatt ttgagaagga gattgatgat gctttacaac aaatctttga tacccatctt 300 gatgtttttc ctaaggatga tctatatgcc accgctctcc gatttggcgt cttaaggaaa 360 caggggcacc gtgtttctcc agatgtattc aaaaaattca aagatgagca ggggaatttc 420 aaggcagagt tgagcaccga tgcgaagggt ttgctatgtt tatatgatgt ggcttatctc 480 agcacaagag gggaagatat cttggatgaa gccattcctt tcactaagga gcaccttagg 540 tcttgtatta gccatgtcga ttctcatatg gcagcaaaaa ttgagcattc tctagagctt 600 ccccttcatc atcgcatacc aaggctagag aacaggcact acatctcagt ctatgaagga 660 gacaaggaaa ggaatgaagt tgtccttgag cttgccaaat tagatttcaa tctgattcaa 720 atcttgcacc aaagagagct gagggacatc acaacgtggt ggaaggagat tgaccttgca 780 gcaaagctac cttttattag ggataggttg gtggagtgct actattggat catgggagtc 840 tattttgaac caatatactc aagggctaga gttttttcga ccaaaatgac aatcttggtc 900 tcagttgtgg acgacatata tgatgtatat gctacagagg atgagctcca acttttcact 960 gatgcaatct ataggtggga tgctgaggac attgagcagc ttccacagta cttgaaagat 1020 gcttttcttg tactctataa cactgtgaag gacctagaag aggaattgga accagaagga 1080 aactcttatc gtggatacta tgtaaaagat gcgatgaagg ttttggcaag ggattacttt 1140 gtggagcaca aatggtataa cagaaaaatt gtgccatcag tagaggacta cctgcgaatt 1200 tcttgcatta gtgttgccgt tcatatggcc acagttcatt gtattgctgg gatgtatgaa 1260 attgcaacca aagaggcatt cgaatggttg aagacggaac ctaaacttgt tatagatgca 1320 tcactgattg ggcgtctcct cgatgacatg cagtccacct cgtttgagca acagagaggt 1380 catgtgtcat cagcggtaca gtgttacatg atccaatatg gggtatcaca cgaagaagcg 1440 tgtgagaagt tgcgagaaat ggctgcaatt gcgtggaaag atgtaaacca agcatgcctt 1500 aggcccactg ttttccctat gcctattctt ctgccctcca tcaaccttgc acgtgtggca 1560 gaagtgattt acctacgcgg agatggatat acacatgcgg gtggtgagac caaaaaacat 1620 atcacggcca tgcttgttga tccaatcaaa gtctga 1656 <210> 5 <211> 551 <212> PRT <213> Drimys winteri <400> 5 Met Ala Ser Thr Leu Pro Leu Pro Ala Tyr Gly Asp Ser Glu Val Val 1 5 10 15 Arg Arg Ser Ala Gly Phe His Pro Thr Ile Trp Gly Asp His Phe Leu 20 25 30 Ser Tyr Lys Pro Asp Pro Thr Lys Ile Asp Glu Trp Asn Lys Arg Val 35 40 45 Glu Glu Leu Lys Glu Glu Val Lys Lys Ile Leu Ser Asn Ala Lys Gly 50 55 60 Thr Val Glu Glu Leu Asn Leu Leu Asp Asp Leu Val His Leu Gly Ile 65 70 75 80 Ser Tyr His Phe Glu Lys Glu Ile Asp Asp Ala Leu Gln Gln Ile Phe 85 90 95 Asp Thr His Leu Asp Val Phe Pro Lys Asp Asp Leu Tyr Ala Thr Ala 100 105 110 Leu Arg Phe Gly Val Leu Arg Lys Gln Gly His Arg Val Ser Pro Asp 115 120 125 Val Phe Lys Lys Phe Lys Asp Glu Gln Gly Asn Phe Lys Ala Glu Leu 130 135 140 Ser Thr Asp Ala Lys Gly Leu Leu Cys Leu Tyr Asp Val Ala Tyr Leu 145 150 155 160 Ser Thr Arg Gly Glu Asp Ile Leu Asp Glu Ala Ile Pro Phe Thr Lys 165 170 175 Glu His Leu Arg Ser Cys Ile Ser His Val Asp Ser His Met Ala Ala 180 185 190 Lys Ile Glu His Ser Leu Glu Leu Pro Leu His His Arg Ile Pro Arg 195 200 205 Leu Glu Asn Arg His Tyr Ile Ser Val Tyr Glu Gly Asp Lys Glu Arg 210 215 220 Asn Glu Val Val Leu Glu Leu Ala Lys Leu Asp Phe Asn Leu Ile Gln 225 230 235 240 Ile Leu His Gln Arg Glu Leu Arg Asp Ile Thr Thr Trp Trp Lys Glu 245 250 255 Ile Asp Leu Ala Ala Lys Leu Pro Phe Ile Arg Asp Arg Leu Val Glu 260 265 270 Cys Tyr Tyr Trp Ile Met Gly Val Tyr Phe Glu Pro Ile Tyr Ser Arg 275 280 285 Ala Arg Val Phe Ser Thr Lys Met Thr Ile Leu Val Ser Val Val Asp 290 295 300 Asp Ile Tyr Asp Val Tyr Ala Thr Glu Asp Glu Leu Gln Leu Phe Thr 305 310 315 320 Asp Ala Ile Tyr Arg Trp Asp Ala Glu Asp Ile Glu Gln Leu Pro Gln 325 330 335 Tyr Leu Lys Asp Ala Phe Leu Val Leu Tyr Asn Thr Val Lys Asp Leu 340 345 350 Glu Glu Glu Leu Glu Pro Glu Gly Asn Ser Tyr Arg Gly Tyr Tyr Val 355 360 365 Lys Asp Ala Met Lys Val Leu Ala Arg Asp Tyr Phe Val Glu His Lys 370 375 380 Trp Tyr Asn Arg Lys Ile Val Pro Ser Val Glu Asp Tyr Leu Arg Ile 385 390 395 400 Ser Cys Ile Ser Val Ala Val His Met Ala Thr Val His Cys Cys Ala 405 410 415 Gly Met Asp Glu Ile Ala Thr Lys Glu Ala Phe Glu Trp Leu Lys Thr 420 425 430 Glu Pro Lys Leu Val Ile Asp Ala Ser Leu Ile Gly Arg Leu Leu Asp 435 440 445 Asp Met Gln Ser Thr Ser Phe Glu Gln Gln Arg Gly His Val Ser Ser 450 455 460 Ala Val Gln Cys Tyr Met Ile Gln Tyr Gly Val Ser His Glu Glu Ala 465 470 475 480 Cys Glu Lys Leu Arg Glu Met Ala Ala Ile Ala Trp Lys Asp Val Asn 485 490 495 Gln Ala Cys Leu Arg Pro Thr Val Phe Pro Met Pro Ile Leu Leu Pro 500 505 510 Ser Ile Asn Leu Ala Arg Val Ala Glu Val Ile Tyr Leu Arg Gly Asp 515 520 525 Gly Tyr Thr His Ala Gly Gly Glu Thr Lys Lys His Ile Thr Ala Met 530 535 540 Leu Val Asp Pro Ile Lys Val 545 550 <210> 6 <211> 1656 <212> DNA <213> Artificial Sequence <220> <223> Codon optimized DNA sequence of SCH51-3228-9 <400> 6 atggcaagca ccctgccgct gcctgcctat ggtgatagcg aagttgttcg tcgtagcgca 60 ggttttcatc cgaccatttg gggtgatcat tttctgagct ataaaccgga tccgaccaaa 120 attgatgaat ggaataaacg tgtcgaagaa ctgaaagaag aagtgaaaaa aatcctgagc 180 aatgccaaag gcaccgttga ggaactgaat ctgctggatg atctggttca tctgggtatc 240 agctatcact ttgagaaaga aatcgatgat gcactgcagc agatttttga tacccatctg 300 gatgttttcc cgaaagatga tctgtatgca accgcactgc gttttggtgt tctgcgtaaa 360 cagggtcatc gtgttagtcc ggatgtgttc aaaaaattca aagatgaaca gggcaacttc 420 aaagcagaac tgagcaccga tgcaaaaggt ctgctgtgtc tgtatgatgt tgcatatctg 480 agcacccgtg gtgaagatat tctggatgaa gcaattccgt ttaccaaaga acatctgcgt 540 agctgtatta gccatgttga tagccacatg gcagcgaaaa ttgaacatag cctggaactg 600 cctctgcatc accgtattcc gcgtctggaa aatcgtcact atattagcgt ttatgagggc 660 gataaagaac gcaatgaagt tgtgctggaa ctggcaaaac tggattttaa cctgattcag 720 attctgcatc agcgtgaact gcgtgatatt accacctggt ggaaagaaat tgatctggca 780 gcaaaactgc cgtttattcg tgatcgtctg gttgaatgct attattggat tatgggcgtg 840 tatttcgaac cgatttatag ccgtgcacgt gtttttagca ccaaaatgac cattctggtt 900 agcgtggtgg atgatatcta tgatgtttat gccaccgaag atgaactgca gctgtttacc 960 gatgccattt atcgttggga tgcagaagat attgaacagc tgccgcagta tctgaaagat 1020 gcatttctgg ttctgtacaa caccgtgaaa gatctggaag aagaactgga accggaaggt 1080 aatagctatc gtggttatta tgttaaagat gccatgaaag ttctggcacg cgattatttt 1140 gttgagcaca aatggtataa ccgcaaaatt gttccgagcg tggaagatta tctgcgtatt 1200 agctgcatta gcgttgcagt tcacatggca accgttcatt gttgtgcagg tatggatgaa 1260 attgcaacca aagaagcatt tgagtggctg aaaaccgaac cgaaactggt tattgatgca 1320 agcctgattg gtcgtctgct ggacgatatg cagagcacca gctttgaaca gcagcgtggt 1380 catgttagca gcgcagttca gtgttatatg attcagtatg gtgttagcca tgaagaagca 1440 tgcgaaaaac tgcgcgaaat ggcagcaatt gcatggaaag atgttaatca ggcatgtctg 1500 cgtccgaccg tttttccgat gccgattctg ctgccgagca ttaatctggc acgtgttgcc 1560 gaagttatct atctgcgtgg tgatggttat acccatgccg gtggtgaaac caaaaaacat 1620 attaccgcaa tgctggtcga tccgattaaa gtttaa 1656 <210> 7 <211> 1656 <212> DNA <213> Drimys winteri <400> 7 atggcttcca ccctccctct cccagcttat ggagattcag aagttgttag gcgatctgcc 60 gggtttcatc cgacgatctg gggcgatcac ttcctctcct acaagcctga tccaacgaaa 120 atagatgaat ggaataaaag ggttgaagag ctgaaggaag aagtgaagaa gatattaagc 180 aatgcaaaag ggacagtgga agagctgaat ttgcttgatg atctcgtaca ccttgggatt 240 agttatcatt ttgagaagga gattgatgat gctttacaac aaatctttga tacccatctt 300 gatgtttttc ctaaggatga tctatatgcc accgctctcc gatttggcgt cttaaggaaa 360 caggggcacc gtgtttctcc agatgtattc aaaaaattca aagatgagca ggggaatttc 420 aaggcagagt tgagcaccga tgcgaagggt ttgctatgtt tatatgatgt ggcttatctc 480 agcacaagag gggaagatat cttggatgaa gccattcctt tcactaagga gcaccttagg 540 tcttgtatta gccatgtcga ttctcatatg gcagcaaaaa ttgagcattc tctagagctt 600 ccccttcatc atcgcatacc aaggctagag aacaggcact acatctcagt ctatgaagga 660 gacaaggaaa ggaatgaagt tgtccttgag cttgccaaat tagatttcaa tctgattcaa 720 atcttgcacc aaagagagct gagggacatc acaatgtggt ggaaggagat tgaccttgca 780 gcaaagctac cttttattag agataggttg gtggagtgct actactggat catgggggtc 840 tattttgaac caatatactc cagggctagg gttttttcca ctaaaatgac aatcttggtc 900 tcagttgtgg acgacatata tgatgtctat gctacggagg atgagcttca actattcact 960 gatgcaatct ataggtggga tgctgatgac attgatcagc tgcctcagta cttgaaagat 1020 gcttttatgg tactctataa cactgtgaag actctagaag aagaacttga accagaagga 1080 aactcttatc gtggatacta cgtaaaagat gcaatgaagg ttttggcaag agattacttt 1140 gtggaacaca aatggtataa cagacaaatt gtgccatccg tagaggaata cttgaaaatt 1200 tcttgcatta gtgtggctgt tcatatggct acagttcatt gtattgctgg gatgtatgaa 1260 attgctacca aagaggcatt cgaatggttg aagactgaac ccaaacttgt tatcgatgca 1320 tctctgatcg gtcgtcttct tgatgacatg cagtctacct cgtttgagca acaaagaggg 1380 cacgtgtcat cagcagtaca gtgttacatg gcccaatatg gagtaacagc agaagaagca 1440 tgtgaaaagc tacgagaaat ggctgcaatt gcttggaaag atgtgaatga agcatgcctt 1500 aggcccacgg tattccctat gcctatcctc ttgccttcta tcaacttggc acgtgtggca 1560 gaagtgatct acctacgtgg agatggatac acgcacgctg ggggtgagac caaaaaacac 1620 atcacggcca tgcttgttaa gccaattgaa gtctga 1656 <210> 8 <211> 551 <212> PRT <213> Drimys winteri <400> 8 Met Ala Ser Thr Leu Pro Leu Pro Ala Tyr Gly Asp Ser Glu Val Val 1 5 10 15 Arg Arg Ser Ala Gly Phe His Pro Thr Ile Trp Gly Asp His Phe Leu 20 25 30 Ser Tyr Lys Pro Asp Pro Thr Lys Ile Asp Glu Trp Asn Lys Arg Val 35 40 45 Glu Glu Leu Lys Glu Glu Val Lys Lys Ile Leu Ser Asn Ala Lys Gly 50 55 60 Thr Val Glu Glu Leu Asn Leu Leu Asp Asp Leu Val His Leu Gly Ile 65 70 75 80 Ser Tyr His Phe Glu Lys Glu Ile Asp Asp Ala Leu Gln Gln Ile Phe 85 90 95 Asp Thr His Leu Asp Val Phe Pro Lys Asp Asp Leu Tyr Ala Thr Ala 100 105 110 Leu Arg Phe Gly Val Leu Arg Lys Gln Gly His Arg Val Ser Pro Asp 115 120 125 Val Phe Lys Lys Phe Lys Asp Glu Gln Gly Asn Phe Lys Ala Glu Leu 130 135 140 Ser Thr Asp Ala Lys Gly Leu Leu Cys Leu Tyr Asp Val Ala Tyr Leu 145 150 155 160 Ser Thr Arg Gly Glu Asp Ile Leu Asp Glu Ala Ile Pro Phe Thr Lys 165 170 175 Glu His Leu Arg Ser Cys Ile Ser His Val Asp Ser His Met Ala Ala 180 185 190 Lys Ile Glu His Ser Leu Glu Leu Pro Leu His His Arg Ile Pro Arg 195 200 205 Leu Glu Asn Arg His Tyr Ile Ser Val Tyr Glu Gly Asp Lys Glu Arg 210 215 220 Asn Glu Val Val Leu Glu Leu Ala Lys Leu Asp Phe Asn Leu Ile Gln 225 230 235 240 Ile Leu His Gln Arg Glu Leu Arg Asp Ile Thr Met Trp Trp Lys Glu 245 250 255 Ile Asp Leu Ala Ala Lys Leu Pro Phe Ile Arg Asp Arg Leu Val Glu 260 265 270 Cys Tyr Tyr Trp Ile Met Gly Val Tyr Phe Glu Pro Ile Tyr Ser Arg 275 280 285 Ala Arg Val Phe Ser Thr Lys Met Thr Ile Leu Val Ser Val Val Asp 290 295 300 Asp Ile Tyr Asp Val Tyr Ala Thr Glu Asp Glu Leu Gln Leu Phe Thr 305 310 315 320 Asp Ala Ile Tyr Arg Trp Asp Ala Asp Asp Ile Asp Gln Leu Pro Gln 325 330 335 Tyr Leu Lys Asp Ala Phe Met Val Leu Tyr Asn Thr Val Lys Thr Leu 340 345 350 Glu Glu Glu Leu Glu Pro Glu Gly Asn Ser Tyr Arg Gly Tyr Tyr Val 355 360 365 Lys Asp Ala Met Lys Val Leu Ala Arg Asp Tyr Phe Val Glu His Lys 370 375 380 Trp Tyr Asn Arg Gln Ile Val Pro Ser Val Glu Glu Tyr Leu Lys Ile 385 390 395 400 Ser Cys Ile Ser Val Ala Val His Met Ala Thr Val His Cys Ile Ala 405 410 415 Gly Met Tyr Glu Ile Ala Thr Lys Glu Ala Phe Glu Trp Leu Lys Thr 420 425 430 Glu Pro Lys Leu Val Ile Asp Ala Ser Leu Ile Gly Arg Leu Leu Asp 435 440 445 Asp Met Gln Ser Thr Ser Phe Glu Gln Gln Arg Gly His Val Ser Ser 450 455 460 Ala Val Gln Cys Tyr Met Ala Gln Tyr Gly Val Thr Ala Glu Glu Ala 465 470 475 480 Cys Glu Lys Leu Arg Glu Met Ala Ala Ile Ala Trp Lys Asp Val Asn 485 490 495 Glu Ala Cys Leu Arg Pro Thr Val Phe Pro Met Pro Ile Leu Leu Pro 500 505 510 Ser Ile Asn Leu Ala Arg Val Ala Glu Val Ile Tyr Leu Arg Gly Asp 515 520 525 Gly Tyr Thr His Ala Gly Gly Glu Thr Lys Lys His Ile Thr Ala Met 530 535 540 Leu Val Lys Pro Ile Glu Val 545 550 <210> 9 <211> 1656 <212> DNA <213> Artificial Sequence <220> <223> Codon optimized DNA sequence of SCH51-3228-11 <400> 9 atggcatcta ctcttccact gccggcttat ggtgattctg aggttgttcg tcgttccgcg 60 ggttttcacc ctaccatctg gggcgatcac tttctgtcct ataagccaga cccgaccaag 120 attgacgagt ggaataagcg tgtcgaggaa ctgaaagaag aagtgaaaaa gatcctgtcc 180 aacgcaaaag gtactgtcga ggagctgaat ctgctggatg acctggtgca tctgggcatc 240 agctatcact tcgaaaagga aattgacgac gctttgcagc aaatttttga tacgcacctg 300 gacgtctttc cgaaagatga cctgtatgcg accgcgctgc gctttggtgt gctgcgtaaa 360 cagggtcatc gcgtgtctcc tgatgtgttc aagaaattta aagatgaaca gggcaatttc 420 aaggccgagt tgagcacgga cgccaaaggt ttgctctgcc tgtacgacgt tgcatatctg 480 agcacccgtg gtgaagatat cctggacgaa gcgattccgt tcaccaagga acatctgcgc 540 tcgtgcattt cccatgtaga tagccacatg gcggccaaga tcgagcacag cctggagctg 600 cctttgcacc atcgtattcc gcgcctggag aatcgccatt acattagcgt ctatgagggt 660 gacaaagagc gcaacgaagt cgtgttagag ctggcgaagc tggacttcaa cctgattcaa 720 attctgcatc aacgcgagct gcgcgacatt accatgtggt ggaaagagat tgatctggca 780 gcgaagctgc cgttcatccg cgatcgtctg gttgagtgct actactggat catgggcgtc 840 tacttcgagc cgatctacag ccgcgctcgt gtgttttcga cgaagatgac catcctggtt 900 agcgttgttg atgacattta tgacgtttac gcgaccgaag atgaactgca gctgtttacg 960 gacgcaatct accgttggga cgcggatgat atcgaccagc tgccgcaata cttgaaagat 1020 gcgttcatgg ttttgtacaa caccgtcaaa acgctggaag aagaactgga gccggaaggc 1080 aacagctacc gtggttacta tgttaaagat gcgatgaaag ttctggcgcg cgactacttc 1140 gtcgagcaca agtggtataa ccgtcagatt gtgccgagcg tcgaggaata cctgaagatt 1200 agctgtatca gcgttgccgt tcacatggca acggtgcact gcatcgccgg tatgtacgag 1260 attgcgacga aagaagcctt cgaatggttg aaaaccgagc cgaagctggt tatcgacgcc 1320 agcctgatcg gtcgtttgct ggacgacatg caaagcacga gcttcgagca gcagcgcggc 1380 catgtgagca gcgctgttca gtgttatatg gcgcaatatg gcgtgaccgc agaagaagcg 1440 tgcgagaagc tgcgtgagat ggcagcaatt gcgtggaaag atgtgaatga agcctgtctg 1500 cgtccgactg tgtttccgat gccgatcctg ctgccgagca ttaacctggc gcgtgtggca 1560 gaggtcatct atctgcgtgg tgacggttac acccacgcgg gtggcgaaac caagaaacat 1620 atcaccgcaa tgctggttaa gccgattgaa gtgtaa 1656 <210> 10 <211> 1677 <212> DNA <213> Drimys winteri <400> 10 atggatctta gtacttcacc tgttctttct tcctcccccc ttccggtgga agacggaaaa 60 aatccggccg ttcgccgttc agctggattt caccccagta tttggggtga tcatttcctc 120 tcctacactg aagatcacaa gaagctggat gcatggagcg aaaggactca agtgttgaag 180 gaagaggtga ggagaatttt aatcaatgcc aaggggtcac tagaagagtt ggatttgttg 240 gatgcaatcc aacgccttgg ggtgaaatat cactttgaga aagagattga agaggcatta 300 caccatattt atgttgcaga aactcatgtt tctactgatg acttatattc cgtttctctc 360 cggtttcgac ttcttagaca acaagggtac aatgtatctg ctgatgtatt taaaaagttc 420 aaagatgaga ggggcaactt caaggcaagc ttaagtactg atgccagggg gttgctaagc 480 ttgtatgaag ctgcatttct cagcatacga ggagatgata tcttagatga agccataact 540 ttcacaagag agcagcttaa gtcttctatg acccatgttg atgcccctct tgccaaacaa 600 atagcccatg ccttagaggt accagcgcac aagcgcatac aaagactaga gaacattcgc 660 tacctcacaa tctaccaaga agagaaagga aggaatgatg tgttgcttga gcttgccaag 720 ttggatttca atatcttaca acaattgcat aagaaagaac tgagagacct tacaaagtgg 780 tggaaggaca cagacgttgc aggaaagcta cctttcatca gagataggtt ggtggaatgc 840 tattattgga tcttgggtgt gtattatgag ccagaatact ccagagctag aattttttct 900 accaaaatga caatcatggt ctcagttgtt gatgacatat atgacgtata tgctactgaa 960 gatgagctcc aactattcac tgatgcaatc tataggtggg atctggaggg cctagatcaa 1020 ctcccacagt tcttgaaaga ctgttttctt gtactctatg acaccgtcaa ggaattagaa 1080 gacgaactag aaccggaagg aaaatcctat cgtggatact atgtaaagga tgcgatgaag 1140 gttttggcta gagattactt cgttgagcac aaatggtata acagaaacat agtgccaagt 1200 gtagaagaat atctccgtgt ttcttgcatc agtgttgcag tccatatggc taacgtccat 1260 tgctgtgctg ggatgggaga tgtaatgagc aaagaggcat tcgaatggtt gaagagtgaa 1320 ccaaaggttg taatggatgc atcactaatt ggccgactgc tcgatgacat gcagtccacc 1380 gagtttgagc aaaagagagg ccatgttgca tcggctgtcc aatgttacat gaatgagtat 1440 ggagtgactt acaaagaagc gtgtgaaaag ctgcatgaaa tggctgccct tgcatggaaa 1500 gacgtaaacc aggcttgcct taaaccaact gttttccctc tccctgtatt tatgcctgca 1560 atcaaccttg cgcgagtggc tgaagtcatc taccttcgtg gagatgggta tactcattca 1620 ggaggagaga ctaaagaaaa tatcacgttg atgcttgtca atccaatctc tgtgtga 1677 <210> 11 <211> 558 <212> PRT <213> Drimys winteri <400> 11 Met Asp Leu Ser Thr Ser Pro Val Leu Ser Ser Ser Pro Leu Pro Val 1 5 10 15 Glu Asp Gly Lys Asn Pro Ala Val Arg Arg Ser Ala Gly Phe His Pro 20 25 30 Ser Ile Trp Gly Asp His Phe Leu Ser Tyr Thr Glu Asp His Lys Lys 35 40 45 Leu Asp Ala Trp Ser Glu Arg Thr Gln Val Leu Lys Glu Glu Val Arg 50 55 60 Arg Ile Leu Ile Asn Ala Lys Gly Ser Leu Glu Glu Leu Asp Leu Leu 65 70 75 80 Asp Ala Ile Gln Arg Leu Gly Val Lys Tyr His Phe Glu Lys Glu Ile 85 90 95 Glu Glu Ala Leu His His Ile Tyr Val Ala Glu Thr His Val Ser Thr 100 105 110 Asp Asp Leu Tyr Ser Val Ser Leu Arg Phe Arg Leu Leu Arg Gln Gln 115 120 125 Gly Tyr Asn Val Ser Ala Asp Val Phe Lys Lys Phe Lys Asp Glu Arg 130 135 140 Gly Asn Phe Lys Ala Ser Leu Ser Thr Asp Ala Arg Gly Leu Leu Ser 145 150 155 160 Leu Tyr Glu Ala Ala Phe Leu Ser Ile Arg Gly Asp Asp Ile Leu Asp 165 170 175 Glu Ala Ile Thr Phe Thr Arg Glu Gln Leu Lys Ser Ser Met Thr His 180 185 190 Val Asp Ala Pro Leu Ala Lys Gln Ile Ala His Ala Leu Glu Val Pro 195 200 205 Ala His Lys Arg Ile Gln Arg Leu Glu Asn Ile Arg Tyr Leu Thr Ile 210 215 220 Tyr Gln Glu Glu Lys Gly Arg Asn Asp Val Leu Leu Glu Leu Ala Lys 225 230 235 240 Leu Asp Phe Asn Ile Leu Gln Gln Leu His Lys Lys Glu Leu Arg Asp 245 250 255 Leu Thr Lys Trp Trp Lys Asp Thr Asp Val Ala Gly Lys Leu Pro Phe 260 265 270 Ile Arg Asp Arg Leu Val Glu Cys Tyr Tyr Trp Ile Leu Gly Val Tyr 275 280 285 Tyr Glu Pro Glu Tyr Ser Arg Ala Arg Ile Phe Ser Thr Lys Met Thr 290 295 300 Ile Met Val Ser Val Val Asp Asp Ile Tyr Asp Val Tyr Ala Thr Glu 305 310 315 320 Asp Glu Leu Gln Leu Phe Thr Asp Ala Ile Tyr Arg Trp Asp Leu Glu 325 330 335 Gly Leu Asp Gln Leu Pro Gln Phe Leu Lys Asp Cys Phe Leu Val Leu 340 345 350 Tyr Asp Thr Val Lys Glu Leu Glu Asp Glu Leu Glu Pro Glu Gly Lys 355 360 365 Ser Tyr Arg Gly Tyr Tyr Val Lys Asp Ala Met Lys Val Leu Ala Arg 370 375 380 Asp Tyr Phe Val Glu His Lys Trp Tyr Asn Arg Asn Ile Val Pro Ser 385 390 395 400 Val Glu Glu Tyr Leu Arg Val Ser Cys Ile Ser Val Ala Val His Met 405 410 415 Ala Asn Val His Cys Cys Ala Gly Met Gly Asp Val Met Ser Lys Glu 420 425 430 Ala Phe Glu Trp Leu Lys Ser Glu Pro Lys Val Val Met Asp Ala Ser 435 440 445 Leu Ile Gly Arg Leu Leu Asp Asp Met Gln Ser Thr Glu Phe Glu Gln 450 455 460 Lys Arg Gly His Val Ala Ser Ala Val Gln Cys Tyr Met Asn Glu Tyr 465 470 475 480 Gly Val Thr Tyr Lys Glu Ala Cys Glu Lys Leu His Glu Met Ala Ala 485 490 495 Leu Ala Trp Lys Asp Val Asn Gln Ala Cys Leu Lys Pro Thr Val Phe 500 505 510 Pro Leu Pro Val Phe Met Pro Ala Ile Asn Leu Ala Arg Val Ala Glu 515 520 525 Val Ile Tyr Leu Arg Gly Asp Gly Tyr Thr His Ser Gly Gly Glu Thr 530 535 540 Lys Glu Asn Ile Thr Leu Met Leu Val Asn Pro Ile Ser Val 545 550 555 <210> 12 <211> 1677 <212> DNA <213> Artificial Sequence <220> <223> Codon optimized DNA sequence of SCH51-998-28 <400> 12 atggatctga gcaccagtcc ggttctgagc agctcaccgc tgccggttga agatggtaaa 60 aatccggcag ttcgtcgtag cgcaggtttt catccgagca tttggggtga tcattttctg 120 agctataccg aggatcacaa aaaactggat gcatggtcag aacgtaccca ggttctgaaa 180 gaagaagtgc gtcgtattct gattaatgca aaaggtagcc tggaagaact ggatctgctg 240 gatgcaattc agcgtctggg tgttaaatat cactttgaga aagaaatcga agaagccctg 300 catcatattt atgttgcaga aacccatgtg tcaaccgatg atctgtatag cgttagcctg 360 cgttttcgtc tgctgcgtca gcagggttat aatgttagcg cagatgtgtt caaaaaattc 420 aaagatgaac gcggtaactt caaagcaagc ctgagcaccg atgcacgtgg tctgctgagc 480 ctgtatgaag cagcatttct gagcattcgt ggtgatgata ttctggatga agcaattacc 540 tttacccgtg aacagctgaa aagcagcatg acccatgttg atgcaccgct ggcaaaacaa 600 attgcacatg cactggaagt tccggcacat aaacgtattc agcgcctgga aaatattcgc 660 tatctgacca tttaccaaga agagaaaggt cgtaacgatg ttctgctgga actggccaaa 720 ctggatttta acattctgca gcagctgcat aaaaaagaac tgcgtgatct gaccaaatgg 780 tggaaagata ccgatgttgc aggtaaactg ccgtttattc gtgatcgtct ggttgaatgc 840 tattattgga ttctgggcgt ttattatgag ccggaatata gccgtgcacg tatttttagc 900 accaaaatga ccattatggt tagcgtggtg gatgacatct atgatgttta tgcaaccgaa 960 gatgaactgc agctgtttac cgatgcaatt tatcgttggg atctggaagg tctggatcag 1020 ctgccgcagt tcctgaaaga ttgttttctg gttctgtatg ataccgtgaa agaactggaa 1080 gatgagctgg aaccggaagg taaaagctat cgtggttatt atgttaaaga tgccatgaaa 1140 gttctggcac gcgattattt tgttgagcac aaatggtata accgcaatat tgttccgagc 1200 gtggaagaat atctgcgtgt tagctgtatt agcgttgcag ttcacatggc aaatgttcat 1260 tgttgtgcag gtatgggtga tgtgatgagc aaagaagcat ttgaatggct gaaaagtgaa 1320 ccgaaagttg ttatggatgc cagcctgatt ggtcgcctgc tggacgatat gcagagcacc 1380 gaatttgaac agaaacgtgg tcatgttgca agcgcagttc agtgttatat gaatgaatat 1440 ggcgtgacct ataaagaggc atgcgaaaaa ctgcatgaaa tggcagcact ggcatggaaa 1500 gatgttaatc aggcatgtct gaaaccgacc gtttttccgc tgcctgtttt tatgcctgca 1560 attaatctgg cacgtgttgc cgaagttatt tacctgcgtg gggatggtta tacccatagc 1620 ggtggtgaaa ccaaagaaaa cattaccctg atgctggtta atccgattag cgtttaa 1677 <210> 13 <211> 1680 <212> DNA <213> Drimys lanceolata <400> 13 atggatgttc taattccctc ccctgtggct tccactctcc ctctgcccga agatggaaac 60 ttggacgtcg ttcgcagatc cgccgggttt catccgacgg tctggggcga tcacttcctc 120 gcttactcgc ccgatccaac caaaatagat gcttggacta aaagagttga agagctgaag 180 caagaagtga agaggattct aagcaatgtg aaagggtcac tggaagagct gaacttgctt 240 gatgctatcc aacaccttgg gattggttat cattttgaga aagagattga tgatgcttta 300 caactaatct ttgattccca tattgatgct tttcctactg atgatctata tgtggctgcc 360 ctccgattta gcctactaag gcgacaaggg cactgtgttt cttcagatgt attcaaaaaa 420 ttcaaagatg agcaggggaa tttcaaggca gagctgagca ccgatgcgaa aggtttgctg 480 agtctctatg acgcggcgta tctcagtgta agaggggaag atatattgga tgaggccatt 540 cctttcacta gggagcacct taggacttgt attagccatg tagattctca tttggcagca 600 aaaattgagc attctctaga gcttcccctg catcatcgca taccaaggct agagaacagg 660 cactacatct cagtgtacga aggagagaag gaaaggaatg aagttgtact agagcttgcc 720 aaattagatt tcaatctgat tcaaatcttg caccaaagag agctgaggga catcacaacg 780 tggtggaatg agattgacct cgcagcaaag ctaccattta ttagggatag gttggtggag 840 tgctactatt ggatcatggg tgtctatttt gaaccaatat tctcaagggc tagagttttt 900 tcgaccaaaa tgacaatttt ggtctcagtt gtcgacgaca tatatgatgt ctacgctaca 960 gaggatgagc tccaactttt cactgacgca atctataggt gggatgccga ggacattgag 1020 cagcttccac agtacttgaa agattctttt cttgtactct ataacaccgt gaaggactta 1080 gaagaggagc tgaaaccaga aggaaactca tatcgtggag actatgtaaa agatgcgatg 1140 aaggttttgg caagagatta ctttgtggag cacaaatggt ataacagaaa aattgtaccg 1200 tcagtagagg actacctacg aatttcttgc attagtgttg ccgttcatat ggctacagtt 1260 cattgttgtg ctgggatgga tgaaattgca accaaagagg cattcgaatg gttgaagacc 1320 gaacctaaac ttgttataga tgcatcactg attgggcgtc tcctcgatga catgcagtcc 1380 acctcgtttg agcaacagag aggtcatgtg tcatcggcgg tacagtgtta catgatccaa 1440 tatggcgtat cacacgaaga agcgtgtgag aagttgacag aaatggctgc aattgcatgg 1500 aaagatgtaa accaagcatg ccttaggccc actgttttcc caatgcctat tcttctgcct 1560 tcaatcaacc ttgcacgtgt ggcagaagtc atctacctgc gcggagatgg atatacacat 1620 gctggtggtg agaccaaaaa acatatcacg gccatgcttg ttgaaccaat ccaagtctga 1680 <210> 14 <211> 559 <212> PRT <213> Drimys lanceolata <400> 14 Met Asp Val Leu Ile Pro Ser Pro Val Ala Ser Thr Leu Pro Leu Pro 1 5 10 15 Glu Asp Gly Asn Leu Asp Val Val Arg Arg Ser Ala Gly Phe His Pro 20 25 30 Thr Val Trp Gly Asp His Phe Leu Ala Tyr Ser Pro Asp Pro Thr Lys 35 40 45 Ile Asp Ala Trp Thr Lys Arg Val Glu Glu Leu Lys Gln Glu Val Lys 50 55 60 Arg Ile Leu Ser Asn Val Lys Gly Ser Leu Glu Glu Leu Asn Leu Leu 65 70 75 80 Asp Ala Ile Gln His Leu Gly Ile Gly Tyr His Phe Glu Lys Glu Ile 85 90 95 Asp Asp Ala Leu Gln Leu Ile Phe Asp Ser His Ile Asp Ala Phe Pro 100 105 110 Thr Asp Asp Leu Tyr Val Ala Ala Leu Arg Phe Ser Leu Leu Arg Arg 115 120 125 Gln Gly His Cys Val Ser Ser Asp Val Phe Lys Lys Phe Lys Asp Glu 130 135 140 Gln Gly Asn Phe Lys Ala Glu Leu Ser Thr Asp Ala Lys Gly Leu Leu 145 150 155 160 Ser Leu Tyr Asp Ala Ala Tyr Leu Ser Val Arg Gly Glu Asp Ile Leu 165 170 175 Asp Glu Ala Ile Pro Phe Thr Arg Glu His Leu Arg Thr Cys Ile Ser 180 185 190 His Val Asp Ser His Leu Ala Ala Lys Ile Glu His Ser Leu Glu Leu 195 200 205 Pro Leu His His Arg Ile Pro Arg Leu Glu Asn Arg His Tyr Ile Ser 210 215 220 Val Tyr Glu Gly Glu Lys Glu Arg Asn Glu Val Val Leu Glu Leu Ala 225 230 235 240 Lys Leu Asp Phe Asn Leu Ile Gln Ile Leu His Gln Arg Glu Leu Arg 245 250 255 Asp Ile Thr Thr Trp Trp Asn Glu Ile Asp Leu Ala Ala Lys Leu Pro 260 265 270 Phe Ile Arg Asp Arg Leu Val Glu Cys Tyr Tyr Trp Ile Met Gly Val 275 280 285 Tyr Phe Glu Pro Ile Phe Ser Arg Ala Arg Val Phe Ser Thr Lys Met 290 295 300 Thr Ile Leu Val Ser Val Val Asp Asp Ile Tyr Asp Val Tyr Ala Thr 305 310 315 320 Glu Asp Glu Leu Gln Leu Phe Thr Asp Ala Ile Tyr Arg Trp Asp Ala 325 330 335 Glu Asp Ile Glu Gln Leu Pro Gln Tyr Leu Lys Asp Ser Phe Leu Val 340 345 350 Leu Tyr Asn Thr Val Lys Asp Leu Glu Glu Glu Leu Lys Pro Glu Gly 355 360 365 Asn Ser Tyr Arg Gly Asp Tyr Val Lys Asp Ala Met Lys Val Leu Ala 370 375 380 Arg Asp Tyr Phe Val Glu His Lys Trp Tyr Asn Arg Lys Ile Val Pro 385 390 395 400 Ser Val Glu Asp Tyr Leu Arg Ile Ser Cys Ile Ser Val Ala Val His 405 410 415 Met Ala Thr Val His Cys Cys Ala Gly Met Asp Glu Ile Ala Thr Lys 420 425 430 Glu Ala Phe Glu Trp Leu Lys Thr Glu Pro Lys Leu Val Ile Asp Ala 435 440 445 Ser Leu Ile Gly Arg Leu Leu Asp Asp Met Gln Ser Thr Ser Phe Glu 450 455 460 Gln Gln Arg Gly His Val Ser Ser Ala Val Gln Cys Tyr Met Ile Gln 465 470 475 480 Tyr Gly Val Ser His Glu Glu Ala Cys Glu Lys Leu Thr Glu Met Ala 485 490 495 Ala Ile Ala Trp Lys Asp Val Asn Gln Ala Cys Leu Arg Pro Thr Val 500 505 510 Phe Pro Met Pro Ile Leu Leu Pro Ser Ile Asn Leu Ala Arg Val Ala 515 520 525 Glu Val Ile Tyr Leu Arg Gly Asp Gly Tyr Thr His Ala Gly Gly Glu 530 535 540 Thr Lys Lys His Ile Thr Ala Met Leu Val Glu Pro Ile Gln Val 545 550 555 <210> 15 <211> 1680 <212> DNA <213> Artificial Sequence <220> <223> Codon optimized DNA sequence of SCH51-13163-6 <400> 15 atggatgttc tgattccgag tccggttgca agcaccctgc cgctgccgga agatggtaat 60 ctggatgttg ttcgtcgtag cgcaggtttt catccgaccg tttggggtga tcattttctg 120 gcatatagtc cggatccgac caaaattgat gcatggacca aacgtgttga ggaactgaaa 180 caagaagtga aacgtattct gagcaatgtg aaaggtagcc tggaagaact gaatctgctg 240 gatgcaattc agcatctggg tattggttat cacttcgaga aagaaattga tgatgcactg 300 cagctgatct ttgatagcca tattgatgcc tttccgaccg atgatctgta tgttgcagca 360 ctgcgtttta gcctgctgcg tcgtcagggt cattgtgtta gcagtgatgt tttcaaaaaa 420 ttcaaagacg agcagggcaa ctttaaagca gaactgagca ccgatgcaaa aggtctgctg 480 agcctgtatg atgccgcata tctgagcgtt cgtggtgaag atattctgga tgaagcaatt 540 ccgtttaccc gtgaacatct gcgtacctgt attagccatg tggatagcca tctggcagca 600 aaaattgaac atagtctgga actgcctctg catcatcgta ttccgcgtct ggaaaatcgt 660 cactatatta gcgtttatga aggcgaaaaa gaacgcaatg aagttgtgct ggaactggca 720 aaactggatt ttaacctgat tcagattctg catcagcgtg aactgcgtga tattaccacc 780 tggtggaatg aaattgacct ggcagccaaa ctgccgttta ttcgtgatcg tctggttgaa 840 tgctattatt ggattatggg cgtgtatttt gaaccgattt ttagccgtgc acgtgtgttt 900 agcaccaaaa tgaccattct ggttagcgtg gtggatgata tctatgatgt ttatgcaacc 960 gaagatgagc tgcaactgtt taccgatgcc atttatcgtt gggatgcaga agatattgaa 1020 cagctgcctc agtatctgaa agatagcttt ctggttctgt acaacaccgt gaaagatctg 1080 gaagaagaac tgaaaccgga aggtaatagc tatcgtggtg attatgttaa agacgccatg 1140 aaagttctgg cacgcgatta ttttgttgag cacaaatggt ataaccgcaa aattgttccg 1200 agcgtggaag attatctgcg tattagctgc attagcgttg cagttcacat ggcaaccgtt 1260 cattgttgtg caggtatgga tgaaattgca accaaagaag catttgagtg gctgaaaacc 1320 gaaccgaaac tggttattga tgcaagcctg attggtcgtc tgctggacga tatgcagtca 1380 accagctttg aacagcagcg tggtcatgtt agcagcgcag ttcagtgtta tatgattcag 1440 tatggtgtta gccatgaaga agcatgcgaa aaactgaccg aaatggcagc aattgcatgg 1500 aaagatgtta atcaggcatg tctgcgtccg accgtgtttc ctatgccgat tctgctgccg 1560 agcattaatc tggcacgtgt tgccgaagtt atctatctgc gtggtgatgg ttatacccat 1620 gccggtggtg aaaccaaaaa acatattacc gcaatgctgg tagaaccgat tcaggtttaa 1680