LISTADO DE SECUENCIAS <110> Dow AgroSciences LLC Armstrong, Janna M. Etter, Audrey J. Frey, Meghan L. Gandra, Premchand Letherer, Ted Lin, Gaofeng Madduri, Krishna M. Mowery, Haley R. Narva, Kenneth E. Sheets, Joel J. Tan, Sek Yee <120> PROTEÍNAS INSECTICIDAS VEGETATIVAS ÚTILES PARA CONTROLAR PLAGAS DE INSECTOS <130> 74948 <160> 13 <170> Patente en versión 3.5 <210> 1 <211> 2412 <212> ADN <213> Bacillus thuringiensis <400> 1 atggtacaaa aatggatgca aaggatgata attgtggata ataataaatt aaatgtaaga 60 gctttaccaa gctttattga ttattttaac ggtatttatg gatttgccac tggtatcaaa 120 gatattatgg gaatgatttt taaaacagat acaggtggta gtaatttaac attagatgag 180 attttaaaga atcaaaattt actaaatgat atctcaggta agctcgatgg aattaatgga 240 gatttagggg atcttattgc acaagggaac ttgaattcag aattagctaa ggaattgcta 300 aaaatctcta atgagcagaa tcaaatgtta aatcatgtta atgctcaact taatgcaatc 360 aattcaacac ttaatatata tcttccaaaa attacatcta tgttaaatga ggtgatgaag 420 caaaaccatg ttttaagtct acaaatagaa tttcttagta agcaattgca ggaaatttca 480 gataaacttg atattatcaa cttaaacgta ttgattaact ctacattaac agagattact 540 cctgcttatc aacgtattaa atatgtaaac gaaaaatttg atgaattgac ttctactgta 600 gagaaaaatc caaaatcata tcaagataac gttactaaag aagttattga aaacttaaat 660 gagctaactg agttggcgaa aagtgttacc aaaaatgata tggatagttt tgaattttat 720 cttcaaactt tccatgatgt aatgactgga aataatttat tcggccgctc agcattaaaa 780 actgcttcag aattaattac aaaagaaaat gtcacgacaa ggggaagtga gataggaaaa 840 gtttataatt tcttaattgt tttaacttct ttacaagcaa aagcttttct cactttaact 900 gcatgtcgaa agttattagg tttaacagat atcgattata ctcaaattat gaatcatcat 960 atagatggtc aaaaaagaga atttcgtatt aatattcttc caacactttc taataatttt 1020 tctaatccta gttattcaaa aaatagagga agtgatatcg atgatccaat tgttgtgtta 1080 gaagcagcac ctggatatgc cttaatagga tttgaaattc taaacgatcc acttccaatt 1140 ttaaaaggat atcaggctag gttaaaacca aattatcaag ttgacaggga gtcgatgtca 1200 gaaacgattt atggggacat tcataaatta ttttgcccaa aacagctgga gcaaaaatat 1260 tatattaaag atattgaatt tcctgagggc tatgtaatta ctaaaatcgt ttttgaaaaa 1320 aggctaaatc aattggggta tgaggtaaca gcaaattttt atgacccgtc tacaggaagt 1380 atcgatttaa ataaggttaa agtagaatct tggaaggaaa agtcttgcga ggaggattcc 1440 tgcgaagatg agtatagtat tataaaggcc gaaacggatg gcatttatat gccattaggc 1500 gtagtaagtg agactttttt aacccctatt tatggttttg gattaacagt tgacgaaaaa 1560 aatcaaaaaa taactttaac aggtaaatcc tatttacgtg aatccttact agaaacagac 1620 ttacttaaca atgaaacata tttaattgct tcaccagacg gttatattag tagtattgta 1680 gaaaactgga atataacatc agataatact gggtcttgga gagcaaataa taataatgca 1740 tttgtcgata aggcagatac tataaaagga tcaagttctc tgtatactca taaagatggg 1800 gaattctcgc aatttattgg aaataagcta aaacctaaaa ctaattatgt tattcaatat 1860 gttataaaag gaagacctgc tatttattta aaaaataata aagatacttt atttgaggat 1920 accaaaaata actttagcga ttttcagact gtaactaaaa aattcaattc aggagtaaat 1980 ccttcggaaa tttatttcct ttttaaaaat caaagtgaat acgaagcctg gggaaataac 2040 tttattattt tagaaattaa atcgcttgaa ttcttgccac aaatgctgaa gcctgaggat 2100 tggataccat caggaaatgt gcaaatgaaa gatggaggac gcctagagat tttgggagat 2160 ggttatttta aacaattcat taaattggaa aatgattcaa cctatcatct aagattatct 2220 gttaagggaa caggtagggt atctataatt gatgaatcta aatatttact ttttgtaaat 2280 gttaaggatg aagatcttac tagagttatt aaaaatacct cttcaaaggg tgagtgtttt 2340 atagctcttg agggtactta tgtagaaaat tcaagtacta ttttctctaa tgtatctatt 2400 gttaaagagt ag 2412 <210> 2 <211> 803 <212> PRT <213> Bacillus thuringiensis <400> 2 Met Val Gln Lys Trp Met Gln Arg Met Ile Ile Val Asp Asn Asn Lys 1 5 10 15 Leu Asn Val Arg Ala Leu Pro Ser Phe Ile Asp Tyr Phe Asn Gly Ile 20 25 30 Tyr Gly Phe Ala Thr Gly Ile Lys Asp Ile Met Gly Met Ile Phe Lys 35 40 45 Thr Asp Thr Gly Gly Ser Asn Leu Thr Leu Asp Glu Ile Leu Lys Asn 50 55 60 Gln Asn Leu Leu Asn Asp Ile Ser Gly Lys Leu Asp Gly Ile Asn Gly 65 70 75 80 Asp Leu Gly Asp Leu Ile Ala Gln Gly Asn Leu Asn Ser Glu Leu Ala 85 90 95 Lys Glu Leu Leu Lys Ile Ser Asn Glu Gln Asn Gln Met Leu Asn His 100 105 110 Val Asn Ala Gln Leu Asn Ala Ile Asn Ser Thr Leu Asn Ile Tyr Leu 115 120 125 Pro Lys Ile Thr Ser Met Leu Asn Glu Val Met Lys Gln Asn His Val 130 135 140 Leu Ser Leu Gln Ile Glu Phe Leu Ser Lys Gln Leu Gln Glu Ile Ser 145 150 155 160 Asp Lys Leu Asp Ile Ile Asn Leu Asn Val Leu Ile Asn Ser Thr Leu 165 170 175 Thr Glu Ile Thr Pro Ala Tyr Gln Arg Ile Lys Tyr Val Asn Glu Lys 180 185 190 Phe Asp Glu Leu Thr Ser Thr Val Glu Lys Asn Pro Lys Ser Tyr Gln 195 200 205 Asp Asn Val Thr Lys Glu Val Ile Glu Asn Leu Asn Glu Leu Thr Glu 210 215 220 Leu Ala Lys Ser Val Thr Lys Asn Asp Met Asp Ser Phe Glu Phe Tyr 225 230 235 240 Leu Gln Thr Phe His Asp Val Met Thr Gly Asn Asn Leu Phe Gly Arg 245 250 255 Ser Ala Leu Lys Thr Ala Ser Glu Leu Ile Thr Lys Glu Asn Val Thr 260 265 270 Thr Arg Gly Ser Glu Ile Gly Lys Val Tyr Asn Phe Leu Ile Val Leu 275 280 285 Thr Ser Leu Gln Ala Lys Ala Phe Leu Thr Leu Thr Ala Cys Arg Lys 290 295 300 Leu Leu Gly Leu Thr Asp Ile Asp Tyr Thr Gln Ile Met Asn His His 305 310 315 320 Ile Asp Gly Gln Lys Arg Glu Phe Arg Ile Asn Ile Leu Pro Thr Leu 325 330 335 Ser Asn Asn Phe Ser Asn Pro Ser Tyr Ser Lys Asn Arg Gly Ser Asp 340 345 350 Ile Asp Asp Pro Ile Val Val Leu Glu Ala Ala Pro Gly Tyr Ala Leu 355 360 365 Ile Gly Phe Glu Ile Leu Asn Asp Pro Leu Pro Ile Leu Lys Gly Tyr 370 375 380 Gln Ala Arg Leu Lys Pro Asn Tyr Gln Val Asp Arg Glu Ser Met Ser 385 390 395 400 Glu Thr Ile Tyr Gly Asp Ile His Lys Leu Phe Cys Pro Lys Gln Leu 405 410 415 Glu Gln Lys Tyr Tyr Ile Lys Asp Ile Glu Phe Pro Glu Gly Tyr Val 420 425 430 Ile Thr Lys Ile Val Phe Glu Lys Arg Leu Asn Gln Leu Gly Tyr Glu 435 440 445 Val Thr Ala Asn Phe Tyr Asp Pro Ser Thr Gly Ser Ile Asp Leu Asn 450 455 460 Lys Val Lys Val Glu Ser Trp Lys Glu Lys Ser Cys Glu Glu Asp Ser 465 470 475 480 Cys Glu Asp Glu Tyr Ser Ile Ile Lys Ala Glu Thr Asp Gly Ile Tyr 485 490 495 Met Pro Leu Gly Val Val Ser Glu Thr Phe Leu Thr Pro Ile Tyr Gly 500 505 510 Phe Gly Leu Thr Val Asp Glu Lys Asn Gln Lys Ile Thr Leu Thr Gly 515 520 525 Lys Ser Tyr Leu Arg Glu Ser Leu Leu Glu Thr Asp Leu Leu Asn Asn 530 535 540 Glu Thr Tyr Leu Ile Ala Ser Pro Asp Gly Tyr Ile Ser Ser Ile Val 545 550 555 560 Glu Asn Trp Asn Ile Thr Ser Asp Asn Thr Gly Ser Trp Arg Ala Asn 565 570 575 Asn Asn Asn Ala Phe Val Asp Lys Ala Asp Thr Ile Lys Gly Ser Ser 580 585 590 Ser Leu Tyr Thr His Lys Asp Gly Glu Phe Ser Gln Phe Ile Gly Asn 595 600 605 Lys Leu Lys Pro Lys Thr Asn Tyr Val Ile Gln Tyr Val Ile Lys Gly 610 615 620 Arg Pro Ala Ile Tyr Leu Lys Asn Asn Lys Asp Thr Leu Phe Glu Asp 625 630 635 640 Thr Lys Asn Asn Phe Ser Asp Phe Gln Thr Val Thr Lys Lys Phe Asn 645 650 655 Ser Gly Val Asn Pro Ser Glu Ile Tyr Phe Leu Phe Lys Asn Gln Ser 660 665 670 Glu Tyr Glu Ala Trp Gly Asn Asn Phe Ile Ile Leu Glu Ile Lys Ser 675 680 685 Leu Glu Phe Leu Pro Gln Met Leu Lys Pro Glu Asp Trp Ile Pro Ser 690 695 700 Gly Asn Val Gln Met Lys Asp Gly Gly Arg Leu Glu Ile Leu Gly Asp 705 710 715 720 Gly Tyr Phe Lys Gln Phe Ile Lys Leu Glu Asn Asp Ser Thr Tyr His 725 730 735 Leu Arg Leu Ser Val Lys Gly Thr Gly Arg Val Ser Ile Ile Asp Glu 740 745 750 Ser Lys Tyr Leu Leu Phe Val Asn Val Lys Asp Glu Asp Leu Thr Arg 755 760 765 Val Ile Lys Asn Thr Ser Ser Lys Gly Glu Cys Phe Ile Ala Leu Glu 770 775 780 Gly Thr Tyr Val Glu Asn Ser Ser Thr Ile Phe Ser Asn Val Ser Ile 785 790 795 800 Val Lys Glu <210> 3 <211> 2412 <212> ADN <213> Secuencia artificial <220> <223> región codificadora sintetizada de longitud completa <400> 3 atggtgcaga aatggatgca gcggatgata attgtagata acaacaagct caacgttcgt 60 gcattgccgt ctttcataga ctatttcaac ggcatatatg ggttcgccac cggcatcaag 120 gacatcatgg gaatgatctt caagaccgac acgggtggat ctaatctgac cctcgatgag 180 atcttgaaaa atcagaatct gctgaatgac atctcaggga aactagacgg tattaacggc 240 gaccttggcg acttgattgc ccaggggaac ctaaactctg aactcgccaa ggaacttctc 300 aagattagca acgaacaaaa tcagatgctc aaccatgtga atgcacaatt gaatgcgatc 360 aatagtactc tcaacatcta ccttcccaag atcacatcca tgctgaacga ggttatgaag 420 caaaaccatg tgttatcgct gcagattgag ttcctgtcaa agcagttgca agagatttcc 480 gataagcttg acatcatcaa cttaaacgtc ctcatcaatt cgaccctcac cgaaattacc 540 cctgcgtatc agagaattaa gtacgtcaac gaaaagtttg acgagctgac cagtaccgtg 600 gagaaaaacc ccaagtcata tcaggataat gtcactaagg aagttattga aaacctcaat 660 gagcttacgg agctggcgaa aagcgtgacg aaaaacgata tggatagctt cgagttttac 720 ctccaaacct tccatgacgt aatgaccggg aacaacctct tcgggaggtc agcgctcaag 780 acagcctccg agttaatcac gaaggagaac gtcacaaccc ggggttcaga aattgggaag 840 gtatacaact tcctaatcgt gcttacgagc cttcaagcta aagctttcct cacactgacg 900 gcctgccgga aactacttgg gctgaccgac atcgactata ctcagattat gaatcaccac 960 atcgacggtc aaaagagaga gtttcgcatt aacattctcc caacgctcag taacaacttc 1020 tccaatccgt cgtattccaa aaaccgaggc tcagatattg acgatcctat tgtcgtcttg 1080 gaggcagcgc cagggtacgc actcatcggc ttcgaaatct taaacgaccc gctgcccatc 1140 cttaagggtt atcaggccag gctgaagccg aactaccagg tggaccgcga atccatgtcc 1200 gaaacgatct acggcgacat ccacaagctg ttctgtccga agcagctcga acaaaagtac 1260 tacattaaag acatcgagtt cccagaggga tatgtgatta cgaaaattgt gttcgaaaag 1320 aggctcaacc aacttggata tgaggtcaca gctaatttct acgatccttc gactggctct 1380 atcgatttga ataaggtgaa ggttgaatcg tggaaggaga aaagctgtga ggaagatagt 1440 tgcgaggatg aatattcaat cataaaggcg gaaacagatg gaatatacat gccgctcggc 1500 gttgtcagcg agacttttct gacccctatc tacggttttg gtctaacagt cgacgagaaa 1560 aaccagaaga tcactctgac cggtaaaagt taccttcgcg agtcgctgct ggagactgac 1620 ctgctgaaca acgagactta cttgatcgct agcccagacg ggtacattag ctctatcgtc 1680 gaaaactgga atatcacctc tgataatact ggctcgtgga gggccaataa caacaatgcg 1740 tttgtggata aagcagatac aatcaaaggc tcaagcagcc tctacacgca caaggatgga 1800 gagttttccc agtttatagg caacaagttg aagccaaaga cgaattacgt tatacagtac 1860 gtgatcaagg gcaggccagc catatacttg aaaaacaata aggacacgct tttcgaagat 1920 acgaagaata acttctccga tttccaaacc gttacaaaga agttcaatag tggagtgaat 1980 cctagcgaga tctactttct gttcaaaaac caatctgagt acgaggcttg gggcaacaac 2040 ttcataattc tagagataaa gtccctggag tttctgcccc agatgctgaa gcccgaggat 2100 tggatcccct ccggcaatgt acagatgaag gacggcggac gcctagagat tctcggcgac 2160 ggctacttta agcagttcat caagttagag aacgactcga cttatcacct tcgtctctca 2220 gtgaagggta cagggagagt cagcatcatc gacgagtcga agtacctttt gttcgtcaac 2280 gttaaggacg aggacctgac acgagtcata aagaatacca gcagtaaggg cgagtgcttt 2340 atcgctttgg agggcactta tgttgagaac tcctctacca tattctccaa tgtttctata 2400 gtgaaggagt ga 2412 <210> 4 <211> 2412 <212> ADN <213> Secuencia artificial <220> <223> región codificadora sintetizada de longitud completa <400> 4 atggcccaga agtggatgca acgcatgatc atcgtggata acaacaagct gaacgtccgt 60 gccctgccga gcttcatcga ctacttcaac ggcatctacg gcttcgcgac cggcattaaa 120 gacattatgg gcatgatctt caagaccgac acgggcggta gcaacttgac cctggacgaa 180 attctgaaga atcagaatct gctcaacgat atcagcggca agctcgacgg cattaacggg 240 gatctgggcg acctgatcgc ccaagggaac ctgaacagcg agctggcgaa agagctgttg 300 aagatctcca acgaacagaa ccagatgctg aaccacgtga atgcccaact gaacgccatc 360 aactcgaccc tgaacatcta cttgcccaag atcacctcga tgttgaacga ggtgatgaag 420 cagaaccatg tgctgagcct gcagattgag ttcctgagca agcagctgca ggaaatctcc 480 gacaagctgg atatcatcaa cctgaatgtg ctgatcaata gcaccttgac cgagatcacc 540 ccggcctatc agcgcatcaa gtacgtgaac gagaagttcg acgaactgac cagcaccgtc 600 gaaaagaatc ccaagtcgta ccaggacaat gtcaccaaag aagtgatcga gaacttgaac 660 gagctcaccg aactggccaa atcggtgacg aagaacgaca tggactcgtt cgaattctat 720 ctgcagacct tccacgacgt gatgaccggc aacaacctgt tcggccgcag cgccctgaaa 780 accgcctcgg aactgatcac gaaagagaat gtgaccaccc gtggctccga gatcggcaag 840 gtgtacaact tcctgattgt cctgacctcg ctgcaggcga aggcgtttct gaccttgacg 900 gcctgccgta agctgttggg cctgaccgac attgactaca cgcagatcat gaatcaccac 960 atcgacggtc agaagcggga attccgcatc aacatcctgc cgaccctgag caataacttc 1020 tccaacccca gctacagcaa gaaccggggc agcgatatcg acgacccgat cgtggtcctc 1080 gaagcggcgc ccggctacgc cctgatcggc ttcgagatcc tgaacgaccc gttgccgatc 1140 ctgaaagggt accaagcgcg cctgaagccg aattaccagg tggatcgcga gtcgatgagc 1200 gaaaccattt acggcgacat tcacaagctg ttctgcccca agcaactcga acagaagtac 1260 tatatcaagg acatcgaatt cccggaaggc tacgtgatta ccaagatcgt ctttgaaaag 1320 cgcctgaacc agctgggtta tgaggtcacc gccaacttct acgacccgag cacgggtagc 1380 atcgacctga ataaggtgaa ggtggaaagc tggaaagaga agtcgtgcga agaggattcg 1440 tgcgaggacg agtatagcat catcaaggcg gaaaccgatg gcatctacat gccgctcggc 1500 gtcgtcagcg aaacctttct caccccgatc tacgggtttg gcttgaccgt ggatgaaaag 1560 aaccagaaaa tcaccctgac cggtaagagc tatctccgcg agtccttgct ggaaacggac 1620 ctgttgaaca acgaaaccta cctgattgcc agcccggatg gttatatctc gtcgattgtg 1680 gagaactgga acatcaccag cgacaacacc ggctcgtggc gtgccaacaa taacaatgcc 1740 ttcgtcgaca aggccgatac gatcaagggt agctccagcc tgtacaccca caaagacggt 1800 gaatttagcc agtttattgg caataagttg aagcccaaga ccaattacgt catccaatac 1860 gtcattaagg gccgtccggc gatctatctg aaaaacaaca aggacaccct cttcgaggat 1920 accaagaaca acttcagcga cttccagacc gtgaccaaga aattcaattc cggtgtgaac 1980 ccgtccgaaa tctatttcct gttcaaaaac cagtcggaat acgaggcctg gggcaacaac 2040 tttatcatcc tggagatcaa gagcctggag tttctgccgc aaatgctgaa acccgaggat 2100 tggattccca gcgggaacgt gcagatgaag gatggtggcc gcctcgaaat cttgggcgac 2160 ggctacttca agcagttcat caagttggaa aacgacagca cctaccatct gcggctgtcc 2220 gtcaagggca ccggccgtgt gtccatcatc gacgagtcca agtatctgct cttcgtgaac 2280 gtgaaggatg aggatctgac ccgcgtgatc aagaacacca gcagcaaagg ggaatgtttc 2340 atcgccctgg aaggcacgta cgtcgagaac tccagcacca tcttcagcaa cgtgtccatc 2400 gtgaaagagt ga 2412 <210> 5 <211> 2412 <212> ADN <213> Secuencia artificial <220> <223> región codificadora sintetizada de longitud completa <400> 5 atggtgcaga agtggatgca gaggatgata atcgttgaca ataataaatt aaacgtgagg 60 gcactgccga gcttcatcga ctacttcaac ggcatctacg gcttcgccac cggcatcaag 120 gacatcatgg gcatgatctt caagaccgac accggaggca gcaacctgac cctggacgag 180 atcctcaaga atcaaaacct cctgaacgac atcagcggga agctggacgg aattaatggc 240 gatcttggag acctgatcgc ccaaggcaac ctcaactccg agctggccaa ggagctgctg 300 aagatttcca acgagcagaa tcaaatgctg aaccacgtga acgctcagct gaacgcaatc 360 aactcaaccc tgaacatcta cctgcccaag atcacgtcca tgctgaacga ggtgatgaag 420 cagaaccatg tgctgtccct ccagatagag ttcctgagca agcagctgca agagatatcc 480 gacaagctgg acatcatcaa cctcaacgtg ctgatcaaca gcaccctcac cgagatcacc 540 cctgcgtacc agaggattaa atacgtgaac gagaagttcg acgaactgac ctccaccgtg 600 gagaagaacc ccaaatccta ccaagacaac gtcaccaagg aggtgatcga gaacctgaac 660 gagctgacgg agctggcgaa gagcgtcacc aagaacgaca tggactcctt cgagttctac 720 ctccagacct tccacgacgt gatgaccggg aataatctgt tcgggcgctc agcattaaag 780 accgcgagcg aattaatcac caaggagaac gtgaccacca gaggctccga gatcggcaag 840 gtgtacaact tcctgatcgt gctcacctcc ctgcaagcga aggcgttcct caccctgacc 900 gcgtgtagga agctgctggg cctgaccgac atcgattaca cccagatcat gaaccaccac 960 atcgacggcc agaagaggga gtttaggatt aatatcctgc cgaccctgtc caataatttc 1020 tccaacccga gctactccaa aaatagaggc tcggacatcg acgaccccat cgtggtgctg 1080 gaggcagccc ctggctacgc cctgatcggc ttcgagatcc tgaacgaccc gctgccgatc 1140 ctcaagggct accaagcgag gctgaaacca aactaccaag tggataggga gagcatgtca 1200 gagaccatct acggggacat ccataaactg ttctgcccaa agcagctgga gcaaaaatat 1260 tacattaaag atatcgagtt cccggagggc tacgtgatca ccaagatcgt gttcgagaag 1320 aggctgaatc aactgggcta cgaagtgacc gccaacttct acgacccgag caccggctcc 1380 atcgacctga acaaggtgaa ggtggagagc tggaaggaga agtcctgtga ggaggactcc 1440 tgcgaggacg agtactccat catcaaggcc gagaccgacg ggatctacat gccgctgggc 1500 gtggtgagcg agaccttcct gaccccgatc tacgggtttg gcctcaccgt ggacgagaaa 1560 aatcaaaaaa taaccctgac cggcaagtcc tacctgaggg agtccctgct ggagaccgac 1620 ctgctgaaca atgaaaccta cctcatcgcc agcccagacg gctacatcag cagcatcgtc 1680 gagaactgga atataacctc cgacaacacc gggagctgga gggccaataa taataatgcc 1740 ttcgtggaca aggcggatac tataaaaggc tcaagcagcc tgtacaccca taaagacggc 1800 gagttctcgc agttcatcgg caacaagctg aagcccaaga ccaactacgt catccagtac 1860 gttataaaag gaaggcctgc gatctacctg aaaaataata aagacaccct gttcgaggac 1920 accaaaaata acttcagcga cttccagacc gtgaccaaga agttcaactc tggcgtgaac 1980 ccgagcgaaa tctacttcct gttcaagaat caatccgagt acgaggcctg gggcaacaac 2040 ttcatcatcc tggaaattaa atccctggag ttcctgccgc agatgctgaa gccggaggac 2100 tggataccga gcggcaacgt gcagatgaaa gacggtggaa ggctggagat cctgggcgac 2160 ggctacttca agcagttcat taaactggag aacgacagca cctaccacct gaggctgagc 2220 gtgaagggaa ctgggagggt gtcgatcatc gacgagtcca agtacctgct gttcgtgaac 2280 gtgaaggacg aggacctgac gagggtgatt aaaaatacct cctccaaggg cgagtgcttc 2340 atcgcgctgg aaggcaccta cgtggagaac agctcaacca tcttctccaa cgtgagcatc 2400 gtgaaggagt ga 2412 <210> 6 <211> 1800 <212> ADN <213> Secuencia artificial <220> <223> región codificadora sintetizada de longitud completa <400> 6 atgtcctacc aagacaacgt caccaaggag gtgatcgaga acctgaacga gctgacggag 60 ctggcgaaga gcgtcaccaa gaacgacatg gactccttcg agttctacct ccagaccttc 120 cacgacgtga tgaccgggaa taatctgttc gggcgctcag cattaaagac cgcgagcgaa 180 ttaatcacca aggagaacgt gaccaccaga ggctccgaga tcggcaaggt gtacaacttc 240 ctgatcgtgc tcacctccct gcaagcgaag gcgttcctca ccctgaccgc gtgtaggaag 300 ctgctgggcc tgaccgacat cgattacacc cagatcatga accaccacat cgacggccag 360 aagagggagt ttaggattaa tatcctgccg accctgtcca ataatttctc caacccgagc 420 tactccaaaa atagaggctc ggacatcgac gaccccatcg tggtgctgga ggcagcccct 480 ggctacgccc tgatcggctt cgagatcctg aacgacccgc tgccgatcct caagggctac 540 caagcgaggc tgaaaccaaa ctaccaagtg gatagggaga gcatgtcaga gaccatctac 600 ggggacatcc ataaactgtt ctgcccaaag cagctggagc aaaaatatta cattaaagat 660 atcgagttcc cggagggcta cgtgatcacc aagatcgtgt tcgagaagag gctgaatcaa 720 ctgggctacg aagtgaccgc caacttctac gacccgagca ccggctccat cgacctgaac 780 aaggtgaagg tggagagctg gaaggagaag tcctgtgagg aggactcctg cgaggacgag 840 tactccatca tcaaggccga gaccgacggg atctacatgc cgctgggcgt ggtgagcgag 900 accttcctga ccccgatcta cgggtttggc ctcaccgtgg acgagaaaaa tcaaaaaata 960 accctgaccg gcaagtccta cctgagggag tccctgctgg agaccgacct gctgaacaat 1020 gaaacctacc tcatcgccag cccagacggc tacatcagca gcatcgtcga gaactggaat 1080 ataacctccg acaacaccgg gagctggagg gccaataata ataatgcctt cgtggacaag 1140 gcggatacta taaaaggctc aagcagcctg tacacccata aagacggcga gttctcgcag 1200 ttcatcggca acaagctgaa gcccaagacc aactacgtca tccagtacgt tataaaagga 1260 aggcctgcga tctacctgaa aaataataaa gacaccctgt tcgaggacac caaaaataac 1320 ttcagcgact tccagaccgt gaccaagaag ttcaactctg gcgtgaaccc gagcgaaatc 1380 tacttcctgt tcaagaatca atccgagtac gaggcctggg gcaacaactt catcatcctg 1440 gaaattaaat ccctggagtt cctgccgcag atgctgaagc cggaggactg gataccgagc 1500 ggcaacgtgc agatgaaaga cggtggaagg ctggagatcc tgggcgacgg ctacttcaag 1560 cagttcatta aactggagaa cgacagcacc taccacctga ggctgagcgt gaagggaact 1620 gggagggtgt cgatcatcga cgagtccaag tacctgctgt tcgtgaacgt gaaggacgag 1680 gacctgacga gggtgattaa aaatacctcc tccaagggcg agtgcttcat cgcgctggaa 1740 ggcacctacg tggagaacag ctcaaccatc ttctccaacg tgagcatcgt gaaggagtga 1800 <210> 7 <211> 599 <212> PRT <213> Secuencia artificial <220> <223> traducida desde la región codificadora sintetizada de longitud completa <400> 7 Met Ser Tyr Gln Asp Asn Val Thr Lys Glu Val Ile Glu Asn Leu Asn 1 5 10 15 Glu Leu Thr Glu Leu Ala Lys Ser Val Thr Lys Asn Asp Met Asp Ser 20 25 30 Phe Glu Phe Tyr Leu Gln Thr Phe His Asp Val Met Thr Gly Asn Asn 35 40 45 Leu Phe Gly Arg Ser Ala Leu Lys Thr Ala Ser Glu Leu Ile Thr Lys 50 55 60 Glu Asn Val Thr Thr Arg Gly Ser Glu Ile Gly Lys Val Tyr Asn Phe 65 70 75 80 Leu Ile Val Leu Thr Ser Leu Gln Ala Lys Ala Phe Leu Thr Leu Thr 85 90 95 Ala Cys Arg Lys Leu Leu Gly Leu Thr Asp Ile Asp Tyr Thr Gln Ile 100 105 110 Met Asn His His Ile Asp Gly Gln Lys Arg Glu Phe Arg Ile Asn Ile 115 120 125 Leu Pro Thr Leu Ser Asn Asn Phe Ser Asn Pro Ser Tyr Ser Lys Asn 130 135 140 Arg Gly Ser Asp Ile Asp Asp Pro Ile Val Val Leu Glu Ala Ala Pro 145 150 155 160 Gly Tyr Ala Leu Ile Gly Phe Glu Ile Leu Asn Asp Pro Leu Pro Ile 165 170 175 Leu Lys Gly Tyr Gln Ala Arg Leu Lys Pro Asn Tyr Gln Val Asp Arg 180 185 190 Glu Ser Met Ser Glu Thr Ile Tyr Gly Asp Ile His Lys Leu Phe Cys 195 200 205 Pro Lys Gln Leu Glu Gln Lys Tyr Tyr Ile Lys Asp Ile Glu Phe Pro 210 215 220 Glu Gly Tyr Val Ile Thr Lys Ile Val Phe Glu Lys Arg Leu Asn Gln 225 230 235 240 Leu Gly Tyr Glu Val Thr Ala Asn Phe Tyr Asp Pro Ser Thr Gly Ser 245 250 255 Ile Asp Leu Asn Lys Val Lys Val Glu Ser Trp Lys Glu Lys Ser Cys 260 265 270 Glu Glu Asp Ser Cys Glu Asp Glu Tyr Ser Ile Ile Lys Ala Glu Thr 275 280 285 Asp Gly Ile Tyr Met Pro Leu Gly Val Val Ser Glu Thr Phe Leu Thr 290 295 300 Pro Ile Tyr Gly Phe Gly Leu Thr Val Asp Glu Lys Asn Gln Lys Ile 305 310 315 320 Thr Leu Thr Gly Lys Ser Tyr Leu Arg Glu Ser Leu Leu Glu Thr Asp 325 330 335 Leu Leu Asn Asn Glu Thr Tyr Leu Ile Ala Ser Pro Asp Gly Tyr Ile 340 345 350 Ser Ser Ile Val Glu Asn Trp Asn Ile Thr Ser Asp Asn Thr Gly Ser 355 360 365 Trp Arg Ala Asn Asn Asn Asn Ala Phe Val Asp Lys Ala Asp Thr Ile 370 375 380 Lys Gly Ser Ser Ser Leu Tyr Thr His Lys Asp Gly Glu Phe Ser Gln 385 390 395 400 Phe Ile Gly Asn Lys Leu Lys Pro Lys Thr Asn Tyr Val Ile Gln Tyr 405 410 415 Val Ile Lys Gly Arg Pro Ala Ile Tyr Leu Lys Asn Asn Lys Asp Thr 420 425 430 Leu Phe Glu Asp Thr Lys Asn Asn Phe Ser Asp Phe Gln Thr Val Thr 435 440 445 Lys Lys Phe Asn Ser Gly Val Asn Pro Ser Glu Ile Tyr Phe Leu Phe 450 455 460 Lys Asn Gln Ser Glu Tyr Glu Ala Trp Gly Asn Asn Phe Ile Ile Leu 465 470 475 480 Glu Ile Lys Ser Leu Glu Phe Leu Pro Gln Met Leu Lys Pro Glu Asp 485 490 495 Trp Ile Pro Ser Gly Asn Val Gln Met Lys Asp Gly Gly Arg Leu Glu 500 505 510 Ile Leu Gly Asp Gly Tyr Phe Lys Gln Phe Ile Lys Leu Glu Asn Asp 515 520 525 Ser Thr Tyr His Leu Arg Leu Ser Val Lys Gly Thr Gly Arg Val Ser 530 535 540 Ile Ile Asp Glu Ser Lys Tyr Leu Leu Phe Val Asn Val Lys Asp Glu 545 550 555 560 Asp Leu Thr Arg Val Ile Lys Asn Thr Ser Ser Lys Gly Glu Cys Phe 565 570 575 Ile Ala Leu Glu Gly Thr Tyr Val Glu Asn Ser Ser Thr Ile Phe Ser 580 585 590 Asn Val Ser Ile Val Lys Glu 595 <210> 8 <211> 2412 <212> ADN <213> Secuencia artificial <220> <223> región codificadora sintetizada de longitud completa <400> 8 atggttcaaa agtggatgca aagaatgata attgttgaca ataataaatt aaatgttaga 60 gcacttccat ctttcattga ttactttaac ggaatctatg gatttgctac tgggattaag 120 gatatcatgg gaatgatctt taagactgat actggtggtt ctaatcttac tcttgatgag 180 atattgaaga atcaaaattt gcttaatgac atttctggca agctggatgg aattaatgga 240 gaccttggtg atcttattgc tcaaggaaac cttaactctg aacttgctaa ggaacttctt 300 aagatttcaa atgagcaaaa tcaaatgttg aaccatgtta acgctcaact taacgcaatc 360 aactctacac ttaacatcta tcttccaaag attacttcaa tgcttaatga ggttatgaag 420 caaaaccacg ttctttctct tcaaattgaa tttctttcta agcaacttca agagatttct 480 gataagctgg atatcattaa ccttaacgtt ctcattaact ctactttgac tgagattact 540 cctgcttacc aaaggattaa atacgttaac gaaaagttcg atgaactgac ttctactgtt 600 gagaagaacc caaagtctta ccaagataac gttactaagg aagttattga aaaccttaat 660 gagcttactg agcttgctaa gtctgttaca aagaacgaca tggattcatt cgagttctat 720 cttcaaactt tccatgatgt tatgactggg aataatcttt tcgggaggtc tgcattaaag 780 actgcttctg aattaatcac taaggaaaac gtaactacta gaggttctga gattggaaag 840 gtgtataact ttcttattgt tcttacttca cttcaagcta aggctttcct tactcttact 900 gcttgtagaa agctccttgg tcttactgac attgattaca ctcagattat gaaccatcat 960 attgatggtc aaaagagaga gtttaggatt aatatccttc caactctttc taataatttc 1020 tcaaatccat cttactctaa aaatagaggt tctgatattg atgatcctat tgtagttctt 1080 gaagctgctc ctggatacgc tcttattgga tttgagatac ttaacgatcc acttcctatt 1140 cttaagggtt atcaagctag acttaaacca aactatcaag ttgatagaga gtctatgtca 1200 gagactatct acggagatat tcataaactc ttttgcccaa agcaacttga gcaaaaatat 1260 tacattaaag atattgaatt tcctgaggga tacgtcatta ctaagatagt ttttgaaaag 1320 agacttaatc aacttggtta cgaggttact gctaactttt acgatccatc taccggatct 1380 attgatctta acaaggttaa ggttgaatct tggaaggaaa agtcttgcga ggaggattct 1440 tgcgaagatg agtattcaat cattaaggct gaaacagatg gcatctatat gccacttgga 1500 gtggtttctg aaacttttct tactcctatc tatggtttcg gacttactgt tgatgagaag 1560 aatcaaaaaa taactttgac tgggaagtct tatcttagag aatctcttct tgaaactgat 1620 cttcttaaca atgaaactta ccttattgct tctccagacg gttacatttc ttctattgtt 1680 gagaactgga atataacttc tgacaatact ggatcttgga gagctaataa taataatgct 1740 tttgtggata aggctgatac tataaaaggt tcttcatctc tttacactca taaagatggt 1800 gagttttctc aattcattgg aaacaaactt aagcctaaga ccaattacgt tattcaatat 1860 gttataaaag ggagacctgc tatctatctt aaaaataata aagatactct tttcgaggat 1920 accaaaaata acttttctga ttttcaaact gttactaaga aattcaattc tggagttaat 1980 ccttctgaaa tctacttcct tttcaagaat caatctgaat acgaggcatg gggaaacaac 2040 tttatcattt tggaaattaa atcacttgag ttccttccac aaatgcttaa gcctgaggat 2100 tggattcctt ctggaaacgt tcagatgaaa gacggaggca gacttgagat tcttggagat 2160 ggttacttta agcaattcat taaattggag aatgattcaa cttaccatct gagactttct 2220 gttaagggaa ctggcagagt ttctatcatt gatgaatcta agtatcttct ttttgtaaat 2280 gttaaggatg aggatctgac tagagtcatt aaaaatactt cttctaaggg tgagtgtttc 2340 attgctcttg agggaactta cgttgaaaac tcttctacca ttttctctaa tgtttcaata 2400 gttaaggagt ga 2412 <210> 9 <211> 1800 <212> ADN <213> Secuencia artificial <220> <223> región codificadora sintetizada de longitud completa <400> 9 atgtcttacc aagataacgt tactaaggaa gttattgaaa accttaatga gcttactgag 60 cttgctaagt ctgttacaaa gaacgacatg gattcattcg agttctatct tcaaactttc 120 catgatgtta tgactgggaa taatcttttc gggaggtctg cattaaagac tgcttctgaa 180 ttaatcacta aggaaaacgt aactactaga ggttctgaga ttggaaaggt gtataacttt 240 cttattgttc ttacttcact tcaagctaag gctttcctta ctcttactgc ttgtagaaag 300 ctccttggtc ttactgacat tgattacact cagattatga accatcatat tgatggtcaa 360 aagagagagt ttaggattaa tatccttcca actctttcta ataatttctc aaatccatct 420 tactctaaaa atagaggttc tgatattgat gatcctattg tagttcttga agctgctcct 480 ggatacgctc ttattggatt tgagatactt aacgatccac ttcctattct taagggttat 540 caagctagac ttaaaccaaa ctatcaagtt gatagagagt ctatgtcaga gactatctac 600 ggagatattc ataaactctt ttgcccaaag caacttgagc aaaaatatta cattaaagat 660 attgaatttc ctgagggata cgtcattact aagatagttt ttgaaaagag acttaatcaa 720 cttggttacg aggttactgc taacttttac gatccatcta ccggatctat tgatcttaac 780 aaggttaagg ttgaatcttg gaaggaaaag tcttgcgagg aggattcttg cgaagatgag 840 tattcaatca ttaaggctga aacagatggc atctatatgc cacttggagt ggtttctgaa 900 acttttctta ctcctatcta tggtttcgga cttactgttg atgagaagaa tcaaaaaata 960 actttgactg ggaagtctta tcttagagaa tctcttcttg aaactgatct tcttaacaat 1020 gaaacttacc ttattgcttc tccagacggt tacatttctt ctattgttga gaactggaat 1080 ataacttctg acaatactgg atcttggaga gctaataata ataatgcttt tgtggataag 1140 gctgatacta taaaaggttc ttcatctctt tacactcata aagatggtga gttttctcaa 1200 ttcattggaa acaaacttaa gcctaagacc aattacgtta ttcaatatgt tataaaaggg 1260 agacctgcta tctatcttaa aaataataaa gatactcttt tcgaggatac caaaaataac 1320 ttttctgatt ttcaaactgt tactaagaaa ttcaattctg gagttaatcc ttctgaaatc 1380 tacttccttt tcaagaatca atctgaatac gaggcatggg gaaacaactt tatcattttg 1440 gaaattaaat cacttgagtt ccttccacaa atgcttaagc ctgaggattg gattccttct 1500 ggaaacgttc agatgaaaga cggaggcaga cttgagattc ttggagatgg ttactttaag 1560 caattcatta aattggagaa tgattcaact taccatctga gactttctgt taagggaact 1620 ggcagagttt ctatcattga tgaatctaag tatcttcttt ttgtaaatgt taaggatgag 1680 gatctgacta gagtcattaa aaatacttct tctaagggtg agtgtttcat tgctcttgag 1740 ggaacttacg ttgaaaactc ttctaccatt ttctctaatg tttcaatagt taaggagtga 1800 <210> 10 <211> 2625 <212> ADN <213> Secuencia artificial <220> <223> región codificadora sintetizada de longitud completa <400> 10 atgttagcta gacaaggtgg atctcttaga gcttctcaat gtaacgctgg acttgctaga 60 agagttgagg ttggtgctct tgttgttcct agaccaattt ctgttaacga cgttgttcca 120 cacgtctatt ctgctcctct ttctgttgct agacgttctt gctctaagtc ctctattaga 180 agtactagaa ggcttcaaac tactgtttgc tcaatggttc aaaagtggat gcaaagaatg 240 ataattgttg acaataataa attaaatgtt agagcacttc catctttcat tgattacttt 300 aacggaatct atggatttgc tactgggatt aaggatatca tgggaatgat ctttaagact 360 gatactggtg gttctaatct tactcttgat gagatattga agaatcaaaa tttgcttaat 420 gacatttctg gcaagctgga tggaattaat ggagaccttg gtgatcttat tgctcaagga 480 aaccttaact ctgaacttgc taaggaactt cttaagattt caaatgagca aaatcaaatg 540 ttgaaccatg ttaacgctca acttaacgca atcaactcta cacttaacat ctatcttcca 600 aagattactt caatgcttaa tgaggttatg aagcaaaacc acgttctttc tcttcaaatt 660 gaatttcttt ctaagcaact tcaagagatt tctgataagc tggatatcat taaccttaac 720 gttctcatta actctacttt gactgagatt actcctgctt accaaaggat taaatacgtt 780 aacgaaaagt tcgatgaact gacttctact gttgagaaga acccaaagtc ttaccaagat 840 aacgttacta aggaagttat tgaaaacctt aatgagctta ctgagcttgc taagtctgtt 900 acaaagaacg acatggattc attcgagttc tatcttcaaa ctttccatga tgttatgact 960 gggaataatc ttttcgggag gtctgcatta aagactgctt ctgaattaat cactaaggaa 1020 aacgtaacta ctagaggttc tgagattgga aaggtgtata actttcttat tgttcttact 1080 tcacttcaag ctaaggcttt ccttactctt actgcttgta gaaagctcct tggtcttact 1140 gacattgatt acactcagat tatgaaccat catattgatg gtcaaaagag agagtttagg 1200 attaatatcc ttccaactct ttctaataat ttctcaaatc catcttactc taaaaataga 1260 ggttctgata ttgatgatcc tattgtagtt cttgaagctg ctcctggata cgctcttatt 1320 ggatttgaga tacttaacga tccacttcct attcttaagg gttatcaagc tagacttaaa 1380 ccaaactatc aagttgatag agagtctatg tcagagacta tctacggaga tattcataaa 1440 ctcttttgcc caaagcaact tgagcaaaaa tattacatta aagatattga atttcctgag 1500 ggatacgtca ttactaagat agtttttgaa aagagactta atcaacttgg ttacgaggtt 1560 actgctaact tttacgatcc atctaccgga tctattgatc ttaacaaggt taaggttgaa 1620 tcttggaagg aaaagtcttg cgaggaggat tcttgcgaag atgagtattc aatcattaag 1680 gctgaaacag atggcatcta tatgccactt ggagtggttt ctgaaacttt tcttactcct 1740 atctatggtt tcggacttac tgttgatgag aagaatcaaa aaataacttt gactgggaag 1800 tcttatctta gagaatctct tcttgaaact gatcttctta acaatgaaac ttaccttatt 1860 gcttctccag acggttacat ttcttctatt gttgagaact ggaatataac ttctgacaat 1920 actggatctt ggagagctaa taataataat gcttttgtgg ataaggctga tactataaaa 1980 ggttcttcat ctctttacac tcataaagat ggtgagtttt ctcaattcat tggaaacaaa 2040 cttaagccta agaccaatta cgttattcaa tatgttataa aagggagacc tgctatctat 2100 cttaaaaata ataaagatac tcttttcgag gataccaaaa ataacttttc tgattttcaa 2160 actgttacta agaaattcaa ttctggagtt aatccttctg aaatctactt ccttttcaag 2220 aatcaatctg aatacgaggc atggggaaac aactttatca ttttggaaat taaatcactt 2280 gagttccttc cacaaatgct taagcctgag gattggattc cttctggaaa cgttcagatg 2340 aaagacggag gcagacttga gattcttgga gatggttact ttaagcaatt cattaaattg 2400 gagaatgatt caacttacca tctgagactt tctgttaagg gaactggcag agtttctatc 2460 attgatgaat ctaagtatct tctttttgta aatgttaagg atgaggatct gactagagtc 2520 attaaaaata cttcttctaa gggtgagtgt ttcattgctc ttgagggaac ttacgttgaa 2580 aactcttcta ccattttctc taatgtttca atagttaagg agtga 2625 <210> 11 <211> 874 <212> PRT <213> Secuencia artificial <220> <223> traducida desde la región codificadora sintetizada de longitud completa <400> 11 Met Leu Ala Arg Gln Gly Gly Ser Leu Arg Ala Ser Gln Cys Asn Ala 1 5 10 15 Gly Leu Ala Arg Arg Val Glu Val Gly Ala Leu Val Val Pro Arg Pro 20 25 30 Ile Ser Val Asn Asp Val Val Pro His Val Tyr Ser Ala Pro Leu Ser 35 40 45 Val Ala Arg Arg Ser Cys Ser Lys Ser Ser Ile Arg Ser Thr Arg Arg 50 55 60 Leu Gln Thr Thr Val Cys Ser Met Val Gln Lys Trp Met Gln Arg Met 65 70 75 80 Ile Ile Val Asp Asn Asn Lys Leu Asn Val Arg Ala Leu Pro Ser Phe 85 90 95 Ile Asp Tyr Phe Asn Gly Ile Tyr Gly Phe Ala Thr Gly Ile Lys Asp 100 105 110 Ile Met Gly Met Ile Phe Lys Thr Asp Thr Gly Gly Ser Asn Leu Thr 115 120 125 Leu Asp Glu Ile Leu Lys Asn Gln Asn Leu Leu Asn Asp Ile Ser Gly 130 135 140 Lys Leu Asp Gly Ile Asn Gly Asp Leu Gly Asp Leu Ile Ala Gln Gly 145 150 155 160 Asn Leu Asn Ser Glu Leu Ala Lys Glu Leu Leu Lys Ile Ser Asn Glu 165 170 175 Gln Asn Gln Met Leu Asn His Val Asn Ala Gln Leu Asn Ala Ile Asn 180 185 190 Ser Thr Leu Asn Ile Tyr Leu Pro Lys Ile Thr Ser Met Leu Asn Glu 195 200 205 Val Met Lys Gln Asn His Val Leu Ser Leu Gln Ile Glu Phe Leu Ser 210 215 220 Lys Gln Leu Gln Glu Ile Ser Asp Lys Leu Asp Ile Ile Asn Leu Asn 225 230 235 240 Val Leu Ile Asn Ser Thr Leu Thr Glu Ile Thr Pro Ala Tyr Gln Arg 245 250 255 Ile Lys Tyr Val Asn Glu Lys Phe Asp Glu Leu Thr Ser Thr Val Glu 260 265 270 Lys Asn Pro Lys Ser Tyr Gln Asp Asn Val Thr Lys Glu Val Ile Glu 275 280 285 Asn Leu Asn Glu Leu Thr Glu Leu Ala Lys Ser Val Thr Lys Asn Asp 290 295 300 Met Asp Ser Phe Glu Phe Tyr Leu Gln Thr Phe His Asp Val Met Thr 305 310 315 320 Gly Asn Asn Leu Phe Gly Arg Ser Ala Leu Lys Thr Ala Ser Glu Leu 325 330 335 Ile Thr Lys Glu Asn Val Thr Thr Arg Gly Ser Glu Ile Gly Lys Val 340 345 350 Tyr Asn Phe Leu Ile Val Leu Thr Ser Leu Gln Ala Lys Ala Phe Leu 355 360 365 Thr Leu Thr Ala Cys Arg Lys Leu Leu Gly Leu Thr Asp Ile Asp Tyr 370 375 380 Thr Gln Ile Met Asn His His Ile Asp Gly Gln Lys Arg Glu Phe Arg 385 390 395 400 Ile Asn Ile Leu Pro Thr Leu Ser Asn Asn Phe Ser Asn Pro Ser Tyr 405 410 415 Ser Lys Asn Arg Gly Ser Asp Ile Asp Asp Pro Ile Val Val Leu Glu 420 425 430 Ala Ala Pro Gly Tyr Ala Leu Ile Gly Phe Glu Ile Leu Asn Asp Pro 435 440 445 Leu Pro Ile Leu Lys Gly Tyr Gln Ala Arg Leu Lys Pro Asn Tyr Gln 450 455 460 Val Asp Arg Glu Ser Met Ser Glu Thr Ile Tyr Gly Asp Ile His Lys 465 470 475 480 Leu Phe Cys Pro Lys Gln Leu Glu Gln Lys Tyr Tyr Ile Lys Asp Ile 485 490 495 Glu Phe Pro Glu Gly Tyr Val Ile Thr Lys Ile Val Phe Glu Lys Arg 500 505 510 Leu Asn Gln Leu Gly Tyr Glu Val Thr Ala Asn Phe Tyr Asp Pro Ser 515 520 525 Thr Gly Ser Ile Asp Leu Asn Lys Val Lys Val Glu Ser Trp Lys Glu 530 535 540 Lys Ser Cys Glu Glu Asp Ser Cys Glu Asp Glu Tyr Ser Ile Ile Lys 545 550 555 560 Ala Glu Thr Asp Gly Ile Tyr Met Pro Leu Gly Val Val Ser Glu Thr 565 570 575 Phe Leu Thr Pro Ile Tyr Gly Phe Gly Leu Thr Val Asp Glu Lys Asn 580 585 590 Gln Lys Ile Thr Leu Thr Gly Lys Ser Tyr Leu Arg Glu Ser Leu Leu 595 600 605 Glu Thr Asp Leu Leu Asn Asn Glu Thr Tyr Leu Ile Ala Ser Pro Asp 610 615 620 Gly Tyr Ile Ser Ser Ile Val Glu Asn Trp Asn Ile Thr Ser Asp Asn 625 630 635 640 Thr Gly Ser Trp Arg Ala Asn Asn Asn Asn Ala Phe Val Asp Lys Ala 645 650 655 Asp Thr Ile Lys Gly Ser Ser Ser Leu Tyr Thr His Lys Asp Gly Glu 660 665 670 Phe Ser Gln Phe Ile Gly Asn Lys Leu Lys Pro Lys Thr Asn Tyr Val 675 680 685 Ile Gln Tyr Val Ile Lys Gly Arg Pro Ala Ile Tyr Leu Lys Asn Asn 690 695 700 Lys Asp Thr Leu Phe Glu Asp Thr Lys Asn Asn Phe Ser Asp Phe Gln 705 710 715 720 Thr Val Thr Lys Lys Phe Asn Ser Gly Val Asn Pro Ser Glu Ile Tyr 725 730 735 Phe Leu Phe Lys Asn Gln Ser Glu Tyr Glu Ala Trp Gly Asn Asn Phe 740 745 750 Ile Ile Leu Glu Ile Lys Ser Leu Glu Phe Leu Pro Gln Met Leu Lys 755 760 765 Pro Glu Asp Trp Ile Pro Ser Gly Asn Val Gln Met Lys Asp Gly Gly 770 775 780 Arg Leu Glu Ile Leu Gly Asp Gly Tyr Phe Lys Gln Phe Ile Lys Leu 785 790 795 800 Glu Asn Asp Ser Thr Tyr His Leu Arg Leu Ser Val Lys Gly Thr Gly 805 810 815 Arg Val Ser Ile Ile Asp Glu Ser Lys Tyr Leu Leu Phe Val Asn Val 820 825 830 Lys Asp Glu Asp Leu Thr Arg Val Ile Lys Asn Thr Ser Ser Lys Gly 835 840 845 Glu Cys Phe Ile Ala Leu Glu Gly Thr Tyr Val Glu Asn Ser Ser Thr 850 855 860 Ile Phe Ser Asn Val Ser Ile Val Lys Glu 865 870 <210> 12 <211> 2013 <212> ADN <213> Secuencia artificial <220> <223> región codificadora sintetizada de longitud completa <400> 12 atgttagcta gacaaggtgg atctcttaga gcttctcaat gtaacgctgg acttgctaga 60 agagttgagg ttggtgctct tgttgttcct agaccaattt ctgttaacga cgttgttcca 120 cacgtctatt ctgctcctct ttctgttgct agacgttctt gctctaagtc ctctattaga 180 agtactagaa ggcttcaaac tactgtttgc tcaatgtctt accaagataa cgttactaag 240 gaagttattg aaaaccttaa tgagcttact gagcttgcta agtctgttac aaagaacgac 300 atggattcat tcgagttcta tcttcaaact ttccatgatg ttatgactgg gaataatctt 360 ttcgggaggt ctgcattaaa gactgcttct gaattaatca ctaaggaaaa cgtaactact 420 agaggttctg agattggaaa ggtgtataac tttcttattg ttcttacttc acttcaagct 480 aaggctttcc ttactcttac tgcttgtaga aagctccttg gtcttactga cattgattac 540 actcagatta tgaaccatca tattgatggt caaaagagag agtttaggat taatatcctt 600 ccaactcttt ctaataattt ctcaaatcca tcttactcta aaaatagagg ttctgatatt 660 gatgatccta ttgtagttct tgaagctgct cctggatacg ctcttattgg atttgagata 720 cttaacgatc cacttcctat tcttaagggt tatcaagcta gacttaaacc aaactatcaa 780 gttgatagag agtctatgtc agagactatc tacggagata ttcataaact cttttgccca 840 aagcaacttg agcaaaaata ttacattaaa gatattgaat ttcctgaggg atacgtcatt 900 actaagatag tttttgaaaa gagacttaat caacttggtt acgaggttac tgctaacttt 960 tacgatccat ctaccggatc tattgatctt aacaaggtta aggttgaatc ttggaaggaa 1020 aagtcttgcg aggaggattc ttgcgaagat gagtattcaa tcattaaggc tgaaacagat 1080 ggcatctata tgccacttgg agtggtttct gaaacttttc ttactcctat ctatggtttc 1140 ggacttactg ttgatgagaa gaatcaaaaa ataactttga ctgggaagtc ttatcttaga 1200 gaatctcttc ttgaaactga tcttcttaac aatgaaactt accttattgc ttctccagac 1260 ggttacattt cttctattgt tgagaactgg aatataactt ctgacaatac tggatcttgg 1320 agagctaata ataataatgc ttttgtggat aaggctgata ctataaaagg ttcttcatct 1380 ctttacactc ataaagatgg tgagttttct caattcattg gaaacaaact taagcctaag 1440 accaattacg ttattcaata tgttataaaa gggagacctg ctatctatct taaaaataat 1500 aaagatactc ttttcgagga taccaaaaat aacttttctg attttcaaac tgttactaag 1560 aaattcaatt ctggagttaa tccttctgaa atctacttcc ttttcaagaa tcaatctgaa 1620 tacgaggcat ggggaaacaa ctttatcatt ttggaaatta aatcacttga gttccttcca 1680 caaatgctta agcctgagga ttggattcct tctggaaacg ttcagatgaa agacggaggc 1740 agacttgaga ttcttggaga tggttacttt aagcaattca ttaaattgga gaatgattca 1800 acttaccatc tgagactttc tgttaaggga actggcagag tttctatcat tgatgaatct 1860 aagtatcttc tttttgtaaa tgttaaggat gaggatctga ctagagtcat taaaaatact 1920 tcttctaagg gtgagtgttt cattgctctt gagggaactt acgttgaaaa ctcttctacc 1980 attttctcta atgtttcaat agttaaggag tga 2013 <210> 13 <211> 670 <212> PRT <213> Secuencia artificial <220> <223> traducida desde la región codificadora sintetizada de longitud completa <400> 13 Met Leu Ala Arg Gln Gly Gly Ser Leu Arg Ala Ser Gln Cys Asn Ala 1 5 10 15 Gly Leu Ala Arg Arg Val Glu Val Gly Ala Leu Val Val Pro Arg Pro 20 25 30 Ile Ser Val Asn Asp Val Val Pro His Val Tyr Ser Ala Pro Leu Ser 35 40 45 Val Ala Arg Arg Ser Cys Ser Lys Ser Ser Ile Arg Ser Thr Arg Arg 50 55 60 Leu Gln Thr Thr Val Cys Ser Met Ser Tyr Gln Asp Asn Val Thr Lys 65 70 75 80 Glu Val Ile Glu Asn Leu Asn Glu Leu Thr Glu Leu Ala Lys Ser Val 85 90 95 Thr Lys Asn Asp Met Asp Ser Phe Glu Phe Tyr Leu Gln Thr Phe His 100 105 110 Asp Val Met Thr Gly Asn Asn Leu Phe Gly Arg Ser Ala Leu Lys Thr 115 120 125 Ala Ser Glu Leu Ile Thr Lys Glu Asn Val Thr Thr Arg Gly Ser Glu 130 135 140 Ile Gly Lys Val Tyr Asn Phe Leu Ile Val Leu Thr Ser Leu Gln Ala 145 150 155 160 Lys Ala Phe Leu Thr Leu Thr Ala Cys Arg Lys Leu Leu Gly Leu Thr 165 170 175 Asp Ile Asp Tyr Thr Gln Ile Met Asn His His Ile Asp Gly Gln Lys 180 185 190 Arg Glu Phe Arg Ile Asn Ile Leu Pro Thr Leu Ser Asn Asn Phe Ser 195 200 205 Asn Pro Ser Tyr Ser Lys Asn Arg Gly Ser Asp Ile Asp Asp Pro Ile 210 215 220 Val Val Leu Glu Ala Ala Pro Gly Tyr Ala Leu Ile Gly Phe Glu Ile 225 230 235 240 Leu Asn Asp Pro Leu Pro Ile Leu Lys Gly Tyr Gln Ala Arg Leu Lys 245 250 255 Pro Asn Tyr Gln Val Asp Arg Glu Ser Met Ser Glu Thr Ile Tyr Gly 260 265 270 Asp Ile His Lys Leu Phe Cys Pro Lys Gln Leu Glu Gln Lys Tyr Tyr 275 280 285 Ile Lys Asp Ile Glu Phe Pro Glu Gly Tyr Val Ile Thr Lys Ile Val 290 295 300 Phe Glu Lys Arg Leu Asn Gln Leu Gly Tyr Glu Val Thr Ala Asn Phe 305 310 315 320 Tyr Asp Pro Ser Thr Gly Ser Ile Asp Leu Asn Lys Val Lys Val Glu 325 330 335 Ser Trp Lys Glu Lys Ser Cys Glu Glu Asp Ser Cys Glu Asp Glu Tyr 340 345 350 Ser Ile Ile Lys Ala Glu Thr Asp Gly Ile Tyr Met Pro Leu Gly Val 355 360 365 Val Ser Glu Thr Phe Leu Thr Pro Ile Tyr Gly Phe Gly Leu Thr Val 370 375 380 Asp Glu Lys Asn Gln Lys Ile Thr Leu Thr Gly Lys Ser Tyr Leu Arg 385 390 395 400 Glu Ser Leu Leu Glu Thr Asp Leu Leu Asn Asn Glu Thr Tyr Leu Ile 405 410 415 Ala Ser Pro Asp Gly Tyr Ile Ser Ser Ile Val Glu Asn Trp Asn Ile 420 425 430 Thr Ser Asp Asn Thr Gly Ser Trp Arg Ala Asn Asn Asn Asn Ala Phe 435 440 445 Val Asp Lys Ala Asp Thr Ile Lys Gly Ser Ser Ser Leu Tyr Thr His 450 455 460 Lys Asp Gly Glu Phe Ser Gln Phe Ile Gly Asn Lys Leu Lys Pro Lys 465 470 475 480 Thr Asn Tyr Val Ile Gln Tyr Val Ile Lys Gly Arg Pro Ala Ile Tyr 485 490 495 Leu Lys Asn Asn Lys Asp Thr Leu Phe Glu Asp Thr Lys Asn Asn Phe 500 505 510 Ser Asp Phe Gln Thr Val Thr Lys Lys Phe Asn Ser Gly Val Asn Pro 515 520 525 Ser Glu Ile Tyr Phe Leu Phe Lys Asn Gln Ser Glu Tyr Glu Ala Trp 530 535 540 Gly Asn Asn Phe Ile Ile Leu Glu Ile Lys Ser Leu Glu Phe Leu Pro 545 550 555 560 Gln Met Leu Lys Pro Glu Asp Trp Ile Pro Ser Gly Asn Val Gln Met 565 570 575 Lys Asp Gly Gly Arg Leu Glu Ile Leu Gly Asp Gly Tyr Phe Lys Gln 580 585 590 Phe Ile Lys Leu Glu Asn Asp Ser Thr Tyr His Leu Arg Leu Ser Val 595 600 605 Lys Gly Thr Gly Arg Val Ser Ile Ile Asp Glu Ser Lys Tyr Leu Leu 610 615 620 Phe Val Asn Val Lys Asp Glu Asp Leu Thr Arg Val Ile Lys Asn Thr 625 630 635 640 Ser Ser Lys Gly Glu Cys Phe Ile Ala Leu Glu Gly Thr Tyr Val Glu 645 650 655 Asn Ser Ser Thr Ile Phe Ser Asn Val Ser Ile Val Lys Glu 660 665 670