LISTADO DE SECUENCIAS <110> Amgen Research (Munich) GmbH Boehringer Ingelheim International GmbH <120> Moléculas de unión para BCMA y CD3 <150> US 61/560,144 <151> 15-11-2011 <150> US 61/560,149 <151> 15-11-2011 <150> US 61/560,162 <151> 15-11-2011 <150> US 61/560,178 <151> 15-11-2011 <150> US 61/560,183 <151> 15-11-2011 <150> US 61/651,486 <151> 24-05-2012 <150> US 61/651,474 <151> 24-05-2012 <160> 1093 <170> PatentIn versión 3.5 <210> 1 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-1 <400> 1 Asn Tyr Asp Met Ala 1 5 <210> 2 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-1 <400> 2 Ser Ile Ile Thr Ser Gly Asp Ala Thr Tyr Tyr Arg Asp Ser Val Lys 1 5 10 15 Gly <210> 3 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-1 <400> 3 His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr 1 5 10 <210> 4 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-1 <400> 4 Lys Ala Ser Gln Ser Val Gly Ile Asn Val Asp 1 5 10 <210> 5 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-1 <400> 5 Gly Ala Ser Asn Arg His Thr 1 5 <210> 6 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-1 <400> 6 Leu Gln Tyr Gly Ser Ile Pro Phe Thr 1 5 <210> 7 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-1 <400> 7 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ser Ile Ile Thr Ser Gly Asp Ala Thr Tyr Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 8 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-1 <400> 8 Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Val Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Gly Ile Asn 20 25 30 Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Asn Arg His Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Arg Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Tyr Gly Ser Ile Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 <210> 9 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-1 scFv <400> 9 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ser Ile Ile Thr Ser Gly Asp Ala Thr Tyr Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 130 135 140 Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Val Thr Leu Ser Cys Lys 145 150 155 160 Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr 180 185 190 Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Arg Glu Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 210 215 220 Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 225 230 235 240 Asp Ile Lys <210> 10 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-1 HL x CD3 HL molécula biespecífica <400> 10 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ser Ile Ile Thr Ser Gly Asp Ala Thr Tyr Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 130 135 140 Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Val Thr Leu Ser Cys Lys 145 150 155 160 Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr 180 185 190 Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Arg Glu Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 210 215 220 Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 225 230 235 240 Asp Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 11 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-2 <400> 11 Asn Tyr Asp Met Ala 1 5 <210> 12 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-2 <400> 12 Ser Ile Ile Thr Ser Gly Asp Met Thr Tyr Tyr Arg Asp Ser Val Lys 1 5 10 15 Gly <210> 13 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-2 <400> 13 His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr 1 5 10 <210> 14 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-2 <400> 14 Lys Ala Ser Gln Ser Val Gly Ile Asn Val Asp 1 5 10 <210> 15 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-2 <400> 15 Gly Ala Ser Asn Arg His Thr 1 5 <210> 16 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-2 <400> 16 Leu Gln Tyr Gly Ser Ile Pro Phe Thr 1 5 <210> 17 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-2 <400> 17 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ser Ile Ile Thr Ser Gly Asp Met Thr Tyr Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 18 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-2 <400> 18 Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Val Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Gly Ile Asn 20 25 30 Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Asn Arg His Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Arg Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Tyr Gly Ser Ile Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 <210> 19 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-2 scFv <400> 19 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ser Ile Ile Thr Ser Gly Asp Met Thr Tyr Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 130 135 140 Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Val Thr Leu Ser Cys Lys 145 150 155 160 Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr 180 185 190 Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Arg Glu Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 210 215 220 Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 225 230 235 240 Asp Ile Lys <210> 20 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-2 HL x CD3 HL molécula biespecífica <400> 20 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ser Ile Ile Thr Ser Gly Asp Met Thr Tyr Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 130 135 140 Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Val Thr Leu Ser Cys Lys 145 150 155 160 Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr 180 185 190 Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Arg Glu Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 210 215 220 Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 225 230 235 240 Asp Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 21 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-3 <400> 21 Asn Tyr Asp Met Ala 1 5 <210> 22 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-3 <400> 22 Ser Ile Ile Thr Ser Gly Asp Ala Thr Tyr Tyr Arg Asp Ser Val Lys 1 5 10 15 Gly <210> 23 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-3 <400> 23 His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr 1 5 10 <210> 24 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-3 <400> 24 Lys Ala Ser Gln Ser Val Gly Ile Asn Val Asp 1 5 10 <210> 25 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-3 <400> 25 Gly Ala Ser Asn Arg His Thr 1 5 <210> 26 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-3 <400> 26 Leu Gln Tyr Gly Ser Ile Pro Phe Thr 1 5 <210> 27 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-3 <400> 27 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ser Ile Ile Thr Ser Gly Asp Ala Thr Tyr Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 28 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-3 <400> 28 Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Val Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Gly Ile Asn 20 25 30 Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Asn Arg His Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Tyr Gly Ser Ile Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 <210> 29 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-3 scFv <400> 29 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ser Ile Ile Thr Ser Gly Asp Ala Thr Tyr Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 130 135 140 Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Val Thr Leu Ser Cys Lys 145 150 155 160 Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr 180 185 190 Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 210 215 220 Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 225 230 235 240 Asp Ile Lys <210> 30 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-3 HL x CD3 HL molécula biespecífica <400> 30 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ser Ile Ile Thr Ser Gly Asp Ala Thr Tyr Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 130 135 140 Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Val Thr Leu Ser Cys Lys 145 150 155 160 Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr 180 185 190 Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 210 215 220 Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 225 230 235 240 Asp Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 31 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-4 <400> 31 Asn Tyr Asp Met Ala 1 5 <210> 32 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-4 <400> 32 Ser Ile Ile Thr Ser Gly Asp Met Thr Tyr Tyr Arg Asp Ser Val Lys 1 5 10 15 Gly <210> 33 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-4 <400> 33 His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr 1 5 10 <210> 34 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-4 <400> 34 Lys Ala Ser Gln Ser Val Gly Ile Asn Val Asp 1 5 10 <210> 35 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-4 <400> 35 Gly Ala Ser Asn Arg His Thr 1 5 <210> 36 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-4 <400> 36 Leu Gln Tyr Gly Ser Ile Pro Phe Thr 1 5 <210> 37 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-4 <400> 37 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ser Ile Ile Thr Ser Gly Asp Met Thr Tyr Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 38 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-4 <400> 38 Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Val Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Gly Ile Asn 20 25 30 Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Asn Arg His Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Tyr Gly Ser Ile Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 <210> 39 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-4 scFv <400> 39 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ser Ile Ile Thr Ser Gly Asp Met Thr Tyr Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 130 135 140 Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Val Thr Leu Ser Cys Lys 145 150 155 160 Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr 180 185 190 Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 210 215 220 Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 225 230 235 240 Asp Ile Lys <210> 40 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-4 HL x CD3 HL molécula biespecífica <400> 40 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ser Ile Ile Thr Ser Gly Asp Met Thr Tyr Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 130 135 140 Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Val Thr Leu Ser Cys Lys 145 150 155 160 Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr 180 185 190 Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 210 215 220 Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 225 230 235 240 Asp Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 41 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-5 <400> 41 Asn Tyr Asp Met Ala 1 5 <210> 42 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-5 <400> 42 Ser Ile Ile Thr Ser Gly Asp Ala Thr Tyr Tyr Arg Asp Ser Val Lys 1 5 10 15 Gly <210> 43 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-5 <400> 43 His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr 1 5 10 <210> 44 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-5 <400> 44 Lys Ala Ser Gln Ser Val Gly Ile Asn Val Asp 1 5 10 <210> 45 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-5 <400> 45 Gly Ala Ser Asn Arg His Thr 1 5 <210> 46 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-5 <400> 46 Leu Gln Tyr Gly Ser Ile Pro Phe Thr 1 5 <210> 47 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-5 <400> 47 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ser Ile Ile Thr Ser Gly Asp Ala Thr Tyr Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 48 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-5 <400> 48 Glu Ile Val Met Thr Gln Ser Pro Ala Ser Met Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Gly Ile Asn 20 25 30 Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Asn Arg His Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Tyr Gly Ser Ile Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 <210> 49 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-5 scFv <400> 49 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ser Ile Ile Thr Ser Gly Asp Ala Thr Tyr Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 130 135 140 Ala Ser Met Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Lys 145 150 155 160 Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr 180 185 190 Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 210 215 220 Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 225 230 235 240 Asp Ile Lys <210> 50 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-5 HL x CD3 HL molécula biespecífica <400> 50 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ser Ile Ile Thr Ser Gly Asp Ala Thr Tyr Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 130 135 140 Ala Ser Met Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Lys 145 150 155 160 Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr 180 185 190 Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 210 215 220 Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 225 230 235 240 Asp Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 51 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-6 <400> 51 Asn Tyr Asp Met Ala 1 5 <210> 52 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-6 <400> 52 Ser Ile Ile Thr Ser Gly Asp Met Thr Tyr Tyr Arg Asp Ser Val Lys 1 5 10 15 Gly <210> 53 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-6 <400> 53 His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr 1 5 10 <210> 54 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-6 <400> 54 Lys Ala Ser Gln Ser Val Gly Ile Asn Val Asp 1 5 10 <210> 55 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-6 <400> 55 Gly Ala Ser Asn Arg His Thr 1 5 <210> 56 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-6 <400> 56 Leu Gln Tyr Gly Ser Ile Pro Phe Thr 1 5 <210> 57 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-6 <400> 57 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ser Ile Ile Thr Ser Gly Asp Met Thr Tyr Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 58 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-6 <400> 58 Glu Ile Val Met Thr Gln Ser Pro Ala Ser Met Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Gly Ile Asn 20 25 30 Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Asn Arg His Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Tyr Gly Ser Ile Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 <210> 59 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-6 scFv <400> 59 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ser Ile Ile Thr Ser Gly Asp Met Thr Tyr Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 130 135 140 Ala Ser Met Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Lys 145 150 155 160 Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr 180 185 190 Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 210 215 220 Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 225 230 235 240 Asp Ile Lys <210> 60 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-6 HL x CD3 HL molécula biespecífica <400> 60 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ser Ile Ile Thr Ser Gly Asp Met Thr Tyr Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 130 135 140 Ala Ser Met Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Lys 145 150 155 160 Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr 180 185 190 Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 210 215 220 Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 225 230 235 240 Asp Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 61 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-7 <400> 61 Asn Tyr Asp Met Ala 1 5 <210> 62 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-7 <400> 62 Ser Ile Ile Thr Ser Gly Asp Ala Thr Tyr Tyr Arg Asp Ser Val Lys 1 5 10 15 Gly <210> 63 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-7 <400> 63 His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr 1 5 10 <210> 64 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-7 <400> 64 Lys Ala Ser Gln Ser Val Gly Ile Asn Val Asp 1 5 10 <210> 65 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-7 <400> 65 Gly Ala Ser Asn Arg His Thr 1 5 <210> 66 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-7 <400> 66 Leu Gln Tyr Gly Ser Ile Pro Phe Thr 1 5 <210> 67 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-7 <400> 67 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ser Ile Ile Thr Ser Gly Asp Ala Thr Tyr Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 68 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-7 <400> 68 Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Gly Ile Asn 20 25 30 Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Asn Arg His Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Tyr Gly Ser Ile Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 <210> 69 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-7 scFv <400> 69 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ser Ile Ile Thr Ser Gly Asp Ala Thr Tyr Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 130 135 140 Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Lys 145 150 155 160 Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr 180 185 190 Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Phe Ala Val Tyr Tyr Cys 210 215 220 Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 225 230 235 240 Asp Ile Lys <210> 70 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-7 HL x CD3 HL molécula biespecífica <400> 70 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ser Ile Ile Thr Ser Gly Asp Ala Thr Tyr Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 130 135 140 Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Lys 145 150 155 160 Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr 180 185 190 Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Phe Ala Val Tyr Tyr Cys 210 215 220 Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 225 230 235 240 Asp Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 71 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-8 <400> 71 Asn Tyr Asp Met Ala 1 5 <210> 72 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-8 <400> 72 Ser Ile Ile Thr Ser Gly Asp Met Thr Tyr Tyr Arg Asp Ser Val Lys 1 5 10 15 Gly <210> 73 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-8 <400> 73 His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr 1 5 10 <210> 74 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-8 <400> 74 Lys Ala Ser Gln Ser Val Gly Ile Asn Val Asp 1 5 10 <210> 75 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-8 <400> 75 Gly Ala Ser Asn Arg His Thr 1 5 <210> 76 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-8 <400> 76 Leu Gln Tyr Gly Ser Ile Pro Phe Thr 1 5 <210> 77 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-8 <400> 77 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ser Ile Ile Thr Ser Gly Asp Met Thr Tyr Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 78 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-8 <400> 78 Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Gly Ile Asn 20 25 30 Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Asn Arg His Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Tyr Gly Ser Ile Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 <210> 79 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-8 scFv <400> 79 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ser Ile Ile Thr Ser Gly Asp Met Thr Tyr Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 130 135 140 Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Lys 145 150 155 160 Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr 180 185 190 Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Phe Ala Val Tyr Tyr Cys 210 215 220 Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 225 230 235 240 Asp Ile Lys <210> 80 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-8 HL x CD3 HL molécula biespecífica <400> 80 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ser Ile Ile Thr Ser Gly Asp Met Thr Tyr Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 130 135 140 Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Lys 145 150 155 160 Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr 180 185 190 Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Phe Ala Val Tyr Tyr Cys 210 215 220 Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 225 230 235 240 Asp Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 81 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-9 <400> 81 Asn Tyr Trp Ile His 1 5 <210> 82 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-9 <400> 82 Ala Ile Tyr Pro Gly Asn Ser Asp Thr His Tyr Asn Gln Lys Phe Gln 1 5 10 15 Gly <210> 83 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-9 <400> 83 Ser Ser Tyr Tyr Tyr Asp Gly Ser Leu Phe Ala Ser 1 5 10 <210> 84 <211> 16 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-9 <400> 84 Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Tyr 1 5 10 15 <210> 85 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-9 <400> 85 Arg Val Ser Asn Arg Phe Ser 1 5 <210> 86 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-9 <400> 86 Phe Gln Gly Ser Thr Leu Pro Phe Thr 1 5 <210> 87 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-9 <400> 87 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Trp Ile His Trp Val Lys Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 35 40 45 Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr His Tyr Asn Gln Lys Phe 50 55 60 Gln Gly Lys Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Thr Arg Ser Ser Tyr Tyr Tyr Asp Gly Ser Leu Phe Ala Ser Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 88 <211> 112 <212> PRT <213> artificial <220> <223> VL de BCMA-9 <400> 88 Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Pro Gly 1 5 10 15 Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 20 25 30 Asn Gly Asn Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Pro 35 40 45 Pro Gln Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 85 90 95 Ser Thr Leu Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 89 <211> 248 <212> PRT <213> artificial <220> <223> BCMA-9 scFv <400> 89 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Trp Ile His Trp Val Lys Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 35 40 45 Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr His Tyr Asn Gln Lys Phe 50 55 60 Gln Gly Lys Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Thr Arg Ser Ser Tyr Tyr Tyr Asp Gly Ser Leu Phe Ala Ser Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro 130 135 140 Leu Ser Leu Ser Val Ser Pro Gly Gln Pro Ala Ser Ile Ser Cys Arg 145 150 155 160 Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp 165 170 175 Tyr Leu Gln Lys Pro Gly Gln Pro Pro Gln Leu Leu Ile Tyr Arg Val 180 185 190 Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser 195 200 205 Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val 210 215 220 Gly Val Tyr Tyr Cys Phe Gln Gly Ser Thr Leu Pro Phe Thr Phe Gly 225 230 235 240 Gln Gly Thr Lys Leu Glu Ile Lys 245 <210> 90 <211> 503 <212> PRT <213> artificial <220> <223> BCMA-9 HL x CD3 HL molécula biespecífica <400> 90 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Trp Ile His Trp Val Lys Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 35 40 45 Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr His Tyr Asn Gln Lys Phe 50 55 60 Gln Gly Lys Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Thr Arg Ser Ser Tyr Tyr Tyr Asp Gly Ser Leu Phe Ala Ser Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro 130 135 140 Leu Ser Leu Ser Val Ser Pro Gly Gln Pro Ala Ser Ile Ser Cys Arg 145 150 155 160 Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp 165 170 175 Tyr Leu Gln Lys Pro Gly Gln Pro Pro Gln Leu Leu Ile Tyr Arg Val 180 185 190 Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser 195 200 205 Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val 210 215 220 Gly Val Tyr Tyr Cys Phe Gln Gly Ser Thr Leu Pro Phe Thr Phe Gly 225 230 235 240 Gln Gly Thr Lys Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val 245 250 255 Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 260 265 270 Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met 275 280 285 Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg 290 295 300 Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val 305 310 315 320 Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr 325 330 335 Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 340 345 350 Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr 355 360 365 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln 385 390 395 400 Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys 405 410 415 Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val 420 425 430 Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys 435 440 445 Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly 450 455 460 Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala 465 470 475 480 Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly 485 490 495 Gly Thr Lys Leu Thr Val Leu 500 <210> 91 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-10 <400> 91 Asn Tyr Trp Ile His 1 5 <210> 92 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-10 <400> 92 Ala Ile Tyr Pro Gly Asn Ser Asp Thr His Tyr Asn Gln Lys Phe Gln 1 5 10 15 Gly <210> 93 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-10 <400> 93 Ser Ser Tyr Tyr Tyr Asp Gly Ser Leu Phe Ala Ser 1 5 10 <210> 94 <211> 16 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-10 <400> 94 Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Tyr 1 5 10 15 <210> 95 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-10 <400> 95 Arg Val Ser Asn Arg Phe Ser 1 5 <210> 96 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-10 <400> 96 Phe Gln Gly Ser His Leu Pro Phe Thr 1 5 <210> 97 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-10 <400> 97 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Trp Ile His Trp Val Lys Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 35 40 45 Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr His Tyr Asn Gln Lys Phe 50 55 60 Gln Gly Lys Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Thr Arg Ser Ser Tyr Tyr Tyr Asp Gly Ser Leu Phe Ala Ser Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 98 <211> 112 <212> PRT <213> artificial <220> <223> VL de BCMA-10 <400> 98 Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Pro Gly 1 5 10 15 Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 20 25 30 Asn Gly Asn Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Pro 35 40 45 Pro Gln Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 85 90 95 Ser His Leu Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 99 <211> 248 <212> PRT <213> artificial <220> <223> BCMA-10 scFv <400> 99 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Trp Ile His Trp Val Lys Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 35 40 45 Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr His Tyr Asn Gln Lys Phe 50 55 60 Gln Gly Lys Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Thr Arg Ser Ser Tyr Tyr Tyr Asp Gly Ser Leu Phe Ala Ser Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro 130 135 140 Leu Ser Leu Ser Val Ser Pro Gly Gln Pro Ala Ser Ile Ser Cys Arg 145 150 155 160 Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp 165 170 175 Tyr Leu Gln Lys Pro Gly Gln Pro Pro Gln Leu Leu Ile Tyr Arg Val 180 185 190 Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser 195 200 205 Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val 210 215 220 Gly Val Tyr Tyr Cys Phe Gln Gly Ser His Leu Pro Phe Thr Phe Gly 225 230 235 240 Gln Gly Thr Lys Leu Glu Ile Lys 245 <210> 100 <211> 503 <212> PRT <213> artificial <220> <223> BCMA-10 HL x CD3 HL molécula biespecífica <400> 100 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Trp Ile His Trp Val Lys Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 35 40 45 Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr His Tyr Asn Gln Lys Phe 50 55 60 Gln Gly Lys Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Thr Arg Ser Ser Tyr Tyr Tyr Asp Gly Ser Leu Phe Ala Ser Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro 130 135 140 Leu Ser Leu Ser Val Ser Pro Gly Gln Pro Ala Ser Ile Ser Cys Arg 145 150 155 160 Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp 165 170 175 Tyr Leu Gln Lys Pro Gly Gln Pro Pro Gln Leu Leu Ile Tyr Arg Val 180 185 190 Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser 195 200 205 Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val 210 215 220 Gly Val Tyr Tyr Cys Phe Gln Gly Ser His Leu Pro Phe Thr Phe Gly 225 230 235 240 Gln Gly Thr Lys Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val 245 250 255 Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 260 265 270 Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met 275 280 285 Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg 290 295 300 Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val 305 310 315 320 Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr 325 330 335 Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 340 345 350 Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr 355 360 365 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln 385 390 395 400 Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys 405 410 415 Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val 420 425 430 Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys 435 440 445 Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly 450 455 460 Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala 465 470 475 480 Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly 485 490 495 Gly Thr Lys Leu Thr Val Leu 500 <210> 101 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-11 <400> 101 Asn Tyr Trp Ile His 1 5 <210> 102 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-11 <400> 102 Ala Ile Tyr Pro Gly Asn Ser Asp Thr His Tyr Asn Gln Lys Phe Gln 1 5 10 15 Gly <210> 103 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-11 <400> 103 Ser Ser Tyr Tyr Tyr Asp Gly Ser Leu Phe Ala Ser 1 5 10 <210> 104 <211> 16 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-11 <400> 104 Lys Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Tyr 1 5 10 15 <210> 105 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-11 <400> 105 Arg Val Ser Asn Arg Phe Ser 1 5 <210> 106 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-11 <400> 106 Phe Gln Gly Ser Thr Leu Pro Phe Thr 1 5 <210> 107 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-11 <400> 107 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Trp Ile His Trp Val Lys Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 35 40 45 Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr His Tyr Asn Gln Lys Phe 50 55 60 Gln Gly Lys Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Thr Arg Ser Ser Tyr Tyr Tyr Asp Gly Ser Leu Phe Ala Ser Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 108 <211> 112 <212> PRT <213> artificial <220> <223> VL de BCMA-11 <400> 108 Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 1 5 10 15 Gln Gln Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Ile Val His Ser 20 25 30 Asn Gly Asn Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Pro 35 40 45 Pro Gln Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 85 90 95 Ser Thr Leu Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 109 <211> 248 <212> PRT <213> artificial <220> <223> BCMA-11 scFv <400> 109 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Trp Ile His Trp Val Lys Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 35 40 45 Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr His Tyr Asn Gln Lys Phe 50 55 60 Gln Gly Lys Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Thr Arg Ser Ser Tyr Tyr Tyr Asp Gly Ser Leu Phe Ala Ser Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro 130 135 140 Leu Ser Leu Ser Val Thr Pro Gly Gln Gln Ala Ser Ile Ser Cys Lys 145 150 155 160 Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp 165 170 175 Tyr Leu Gln Lys Pro Gly Gln Pro Pro Gln Leu Leu Ile Tyr Arg Val 180 185 190 Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser 195 200 205 Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val 210 215 220 Gly Val Tyr Tyr Cys Phe Gln Gly Ser Thr Leu Pro Phe Thr Phe Gly 225 230 235 240 Gln Gly Thr Lys Leu Glu Ile Lys 245 <210> 110 <211> 503 <212> PRT <213> artificial <220> <223> BCMA-11 HL x CD3 HL molécula biespecífica <400> 110 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Trp Ile His Trp Val Lys Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 35 40 45 Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr His Tyr Asn Gln Lys Phe 50 55 60 Gln Gly Lys Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Thr Arg Ser Ser Tyr Tyr Tyr Asp Gly Ser Leu Phe Ala Ser Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro 130 135 140 Leu Ser Leu Ser Val Thr Pro Gly Gln Gln Ala Ser Ile Ser Cys Lys 145 150 155 160 Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp 165 170 175 Tyr Leu Gln Lys Pro Gly Gln Pro Pro Gln Leu Leu Ile Tyr Arg Val 180 185 190 Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser 195 200 205 Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val 210 215 220 Gly Val Tyr Tyr Cys Phe Gln Gly Ser Thr Leu Pro Phe Thr Phe Gly 225 230 235 240 Gln Gly Thr Lys Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val 245 250 255 Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 260 265 270 Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met 275 280 285 Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg 290 295 300 Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val 305 310 315 320 Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr 325 330 335 Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 340 345 350 Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr 355 360 365 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln 385 390 395 400 Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys 405 410 415 Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val 420 425 430 Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys 435 440 445 Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly 450 455 460 Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala 465 470 475 480 Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly 485 490 495 Gly Thr Lys Leu Thr Val Leu 500 <210> 111 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-12 <400> 111 Asn Tyr Trp Ile His 1 5 <210> 112 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-12 <400> 112 Ala Ile Tyr Pro Gly Asn Ser Asp Thr His Tyr Asn Gln Lys Phe Gln 1 5 10 15 Gly <210> 113 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-12 <400> 113 Ser Ser Tyr Tyr Tyr Asp Gly Ser Leu Phe Ala Ser 1 5 10 <210> 114 <211> 16 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-12 <400> 114 Lys Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Tyr 1 5 10 15 <210> 115 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-12 <400> 115 Arg Val Ser Asn Arg Phe Ser 1 5 <210> 116 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-12 <400> 116 Phe Gln Gly Ser His Leu Pro Phe Thr 1 5 <210> 117 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-12 <400> 117 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Trp Ile His Trp Val Lys Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 35 40 45 Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr His Tyr Asn Gln Lys Phe 50 55 60 Gln Gly Lys Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Thr Arg Ser Ser Tyr Tyr Tyr Asp Gly Ser Leu Phe Ala Ser Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 118 <211> 112 <212> PRT <213> artificial <220> <223> VL de BCMA-12 <400> 118 Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 1 5 10 15 Gln Gln Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Ile Val His Ser 20 25 30 Asn Gly Asn Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Pro 35 40 45 Pro Gln Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 85 90 95 Ser His Leu Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 119 <211> 248 <212> PRT <213> artificial <220> <223> BCMA-12 scFv <400> 119 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Trp Ile His Trp Val Lys Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 35 40 45 Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr His Tyr Asn Gln Lys Phe 50 55 60 Gln Gly Lys Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Thr Arg Ser Ser Tyr Tyr Tyr Asp Gly Ser Leu Phe Ala Ser Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro 130 135 140 Leu Ser Leu Ser Val Thr Pro Gly Gln Gln Ala Ser Ile Ser Cys Lys 145 150 155 160 Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp 165 170 175 Tyr Leu Gln Lys Pro Gly Gln Pro Pro Gln Leu Leu Ile Tyr Arg Val 180 185 190 Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser 195 200 205 Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val 210 215 220 Gly Val Tyr Tyr Cys Phe Gln Gly Ser His Leu Pro Phe Thr Phe Gly 225 230 235 240 Gln Gly Thr Lys Leu Glu Ile Lys 245 <210> 120 <211> 503 <212> PRT <213> artificial <220> <223> BCMA-12 HL x CD3 HL molécula biespecífica <400> 120 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Trp Ile His Trp Val Lys Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 35 40 45 Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr His Tyr Asn Gln Lys Phe 50 55 60 Gln Gly Lys Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Thr Arg Ser Ser Tyr Tyr Tyr Asp Gly Ser Leu Phe Ala Ser Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro 130 135 140 Leu Ser Leu Ser Val Thr Pro Gly Gln Gln Ala Ser Ile Ser Cys Lys 145 150 155 160 Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp 165 170 175 Tyr Leu Gln Lys Pro Gly Gln Pro Pro Gln Leu Leu Ile Tyr Arg Val 180 185 190 Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser 195 200 205 Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val 210 215 220 Gly Val Tyr Tyr Cys Phe Gln Gly Ser His Leu Pro Phe Thr Phe Gly 225 230 235 240 Gln Gly Thr Lys Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val 245 250 255 Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 260 265 270 Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met 275 280 285 Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg 290 295 300 Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val 305 310 315 320 Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr 325 330 335 Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 340 345 350 Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr 355 360 365 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln 385 390 395 400 Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys 405 410 415 Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val 420 425 430 Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys 435 440 445 Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly 450 455 460 Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala 465 470 475 480 Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly 485 490 495 Gly Thr Lys Leu Thr Val Leu 500 <210> 121 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-13 <400> 121 Asn Tyr Trp Ile His 1 5 <210> 122 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-13 <400> 122 Ala Ile Tyr Pro Gly Asn Ser Asp Thr His Tyr Asn Gln Lys Phe Gln 1 5 10 15 Gly <210> 123 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-13 <400> 123 Ser Ser Tyr Tyr Tyr Asp Gly Ser Leu Phe Ala Ser 1 5 10 <210> 124 <211> 16 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-13 <400> 124 Lys Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Tyr 1 5 10 15 <210> 125 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-13 <400> 125 Arg Val Ser Asn Arg Phe Ser 1 5 <210> 126 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-13 <400> 126 Phe Gln Gly Ser Thr Leu Pro Phe Thr 1 5 <210> 127 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-13 <400> 127 Gln Val Gln Leu Val Gln Ser Gly Ala Val Val Ala Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Trp Ile His Trp Val Lys Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 35 40 45 Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr His Tyr Asn Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Leu Thr Thr Asp Thr Ser Ala Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Asn Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Thr Arg Ser Ser Tyr Tyr Tyr Asp Gly Ser Leu Phe Ala Ser Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 128 <211> 112 <212> PRT <213> artificial <220> <223> VL de BCMA-13 <400> 128 Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 1 5 10 15 Gln Gln Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Ile Val His Ser 20 25 30 Asn Gly Asn Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Pro 35 40 45 Pro Gln Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 85 90 95 Ser Thr Leu Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 129 <211> 248 <212> PRT <213> artificial <220> <223> BCMA-13 scFv <400> 129 Gln Val Gln Leu Val Gln Ser Gly Ala Val Val Ala Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Trp Ile His Trp Val Lys Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 35 40 45 Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr His Tyr Asn Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Leu Thr Thr Asp Thr Ser Ala Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Asn Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Thr Arg Ser Ser Tyr Tyr Tyr Asp Gly Ser Leu Phe Ala Ser Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro 130 135 140 Leu Ser Leu Ser Val Thr Pro Gly Gln Gln Ala Ser Ile Ser Cys Lys 145 150 155 160 Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp 165 170 175 Tyr Leu Gln Lys Pro Gly Gln Pro Pro Gln Leu Leu Ile Tyr Arg Val 180 185 190 Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser 195 200 205 Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val 210 215 220 Gly Val Tyr Tyr Cys Phe Gln Gly Ser Thr Leu Pro Phe Thr Phe Gly 225 230 235 240 Gln Gly Thr Lys Leu Glu Ile Lys 245 <210> 130 <211> 503 <212> PRT <213> artificial <220> <223> BCMA-13 HL x CD3 HL molécula biespecífica <400> 130 Gln Val Gln Leu Val Gln Ser Gly Ala Val Val Ala Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Trp Ile His Trp Val Lys Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 35 40 45 Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr His Tyr Asn Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Leu Thr Thr Asp Thr Ser Ala Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Asn Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Thr Arg Ser Ser Tyr Tyr Tyr Asp Gly Ser Leu Phe Ala Ser Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro 130 135 140 Leu Ser Leu Ser Val Thr Pro Gly Gln Gln Ala Ser Ile Ser Cys Lys 145 150 155 160 Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp 165 170 175 Tyr Leu Gln Lys Pro Gly Gln Pro Pro Gln Leu Leu Ile Tyr Arg Val 180 185 190 Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser 195 200 205 Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val 210 215 220 Gly Val Tyr Tyr Cys Phe Gln Gly Ser Thr Leu Pro Phe Thr Phe Gly 225 230 235 240 Gln Gly Thr Lys Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val 245 250 255 Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 260 265 270 Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met 275 280 285 Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg 290 295 300 Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val 305 310 315 320 Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr 325 330 335 Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 340 345 350 Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr 355 360 365 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln 385 390 395 400 Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys 405 410 415 Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val 420 425 430 Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys 435 440 445 Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly 450 455 460 Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala 465 470 475 480 Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly 485 490 495 Gly Thr Lys Leu Thr Val Leu 500 <210> 131 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-14 <400> 131 Asn Tyr Trp Ile His 1 5 <210> 132 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-14 <400> 132 Ala Ile Tyr Pro Gly Asn Ser Asp Thr His Tyr Asn Gln Lys Phe Gln 1 5 10 15 Gly <210> 133 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-14 <400> 133 Ser Ser Tyr Tyr Tyr Asp Gly Ser Leu Phe Ala Ser 1 5 10 <210> 134 <211> 16 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-14 <400> 134 Lys Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Tyr 1 5 10 15 <210> 135 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-14 <400> 135 Arg Val Ser Asn Arg Phe Ser 1 5 <210> 136 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-14 <400> 136 Phe Gln Gly Ser His Leu Pro Phe Thr 1 5 <210> 137 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-14 <400> 137 Gln Val Gln Leu Val Gln Ser Gly Ala Val Val Ala Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Trp Ile His Trp Val Lys Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 35 40 45 Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr His Tyr Asn Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Leu Thr Thr Asp Thr Ser Ala Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Asn Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Thr Arg Ser Ser Tyr Tyr Tyr Asp Gly Ser Leu Phe Ala Ser Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 138 <211> 112 <212> PRT <213> artificial <220> <223> VL de BCMA-14 <400> 138 Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 1 5 10 15 Gln Gln Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Ile Val His Ser 20 25 30 Asn Gly Asn Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Pro 35 40 45 Pro Gln Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 85 90 95 Ser His Leu Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 139 <211> 248 <212> PRT <213> artificial <220> <223> BCMA-14 scFv <400> 139 Gln Val Gln Leu Val Gln Ser Gly Ala Val Val Ala Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Trp Ile His Trp Val Lys Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 35 40 45 Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr His Tyr Asn Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Leu Thr Thr Asp Thr Ser Ala Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Asn Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Thr Arg Ser Ser Tyr Tyr Tyr Asp Gly Ser Leu Phe Ala Ser Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro 130 135 140 Leu Ser Leu Ser Val Thr Pro Gly Gln Gln Ala Ser Ile Ser Cys Lys 145 150 155 160 Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp 165 170 175 Tyr Leu Gln Lys Pro Gly Gln Pro Pro Gln Leu Leu Ile Tyr Arg Val 180 185 190 Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser 195 200 205 Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val 210 215 220 Gly Val Tyr Tyr Cys Phe Gln Gly Ser His Leu Pro Phe Thr Phe Gly 225 230 235 240 Gln Gly Thr Lys Leu Glu Ile Lys 245 <210> 140 <211> 503 <212> PRT <213> artificial <220> <223> BCMA-14 HL x CD3 HL molécula biespecífica <400> 140 Gln Val Gln Leu Val Gln Ser Gly Ala Val Val Ala Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Trp Ile His Trp Val Lys Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 35 40 45 Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr His Tyr Asn Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Leu Thr Thr Asp Thr Ser Ala Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Asn Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Thr Arg Ser Ser Tyr Tyr Tyr Asp Gly Ser Leu Phe Ala Ser Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro 130 135 140 Leu Ser Leu Ser Val Thr Pro Gly Gln Gln Ala Ser Ile Ser Cys Lys 145 150 155 160 Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp 165 170 175 Tyr Leu Gln Lys Pro Gly Gln Pro Pro Gln Leu Leu Ile Tyr Arg Val 180 185 190 Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser 195 200 205 Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val 210 215 220 Gly Val Tyr Tyr Cys Phe Gln Gly Ser His Leu Pro Phe Thr Phe Gly 225 230 235 240 Gln Gly Thr Lys Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val 245 250 255 Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 260 265 270 Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met 275 280 285 Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg 290 295 300 Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val 305 310 315 320 Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr 325 330 335 Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 340 345 350 Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr 355 360 365 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln 385 390 395 400 Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys 405 410 415 Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val 420 425 430 Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys 435 440 445 Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly 450 455 460 Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala 465 470 475 480 Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly 485 490 495 Gly Thr Lys Leu Thr Val Leu 500 <210> 141 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-15 <400> 141 Ser Tyr Trp Ile His 1 5 <210> 142 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-15 <400> 142 Ala Ile Tyr Pro Gly Asn Ser Asp Thr His Tyr Asn Gln Lys Phe Gln 1 5 10 15 Gly <210> 143 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-15 <400> 143 Ser Ser Tyr Tyr Tyr Asp Gly Ser Leu Phe Ala Asp 1 5 10 <210> 144 <211> 16 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-15 <400> 144 Lys Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Tyr 1 5 10 15 <210> 145 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-15 <400> 145 Arg Val Ser Asn Arg Phe Ser 1 5 <210> 146 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-15 <400> 146 Phe Gln Gly Ser Thr Leu Pro Phe Thr 1 5 <210> 147 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-15 <400> 147 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Thr 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Trp Ile His Trp Val Lys Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 35 40 45 Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr His Tyr Asn Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Leu Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Tyr Cys 85 90 95 Thr Arg Ser Ser Tyr Tyr Tyr Asp Gly Ser Leu Phe Ala Asp Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 148 <211> 112 <212> PRT <213> artificial <220> <223> VL de BCMA-15 <400> 148 Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 1 5 10 15 Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Ile Val His Ser 20 25 30 Asn Gly Asn Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Pro 35 40 45 Pro Gln Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 85 90 95 Ser Thr Leu Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 149 <211> 248 <212> PRT <213> artificial <220> <223> BCMA-15 scFv <400> 149 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Thr 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Trp Ile His Trp Val Lys Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 35 40 45 Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr His Tyr Asn Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Leu Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Tyr Cys 85 90 95 Thr Arg Ser Ser Tyr Tyr Tyr Asp Gly Ser Leu Phe Ala Asp Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro 130 135 140 Leu Ser Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Lys 145 150 155 160 Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp 165 170 175 Tyr Leu Gln Lys Pro Gly Gln Pro Pro Gln Leu Leu Ile Tyr Arg Val 180 185 190 Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser 195 200 205 Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val 210 215 220 Gly Val Tyr Tyr Cys Phe Gln Gly Ser Thr Leu Pro Phe Thr Phe Gly 225 230 235 240 Gln Gly Thr Lys Leu Glu Ile Lys 245 <210> 150 <211> 503 <212> PRT <213> artificial <220> <223> BCMA-15 HL x CD3 HL molécula biespecífica <400> 150 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Thr 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Trp Ile His Trp Val Lys Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 35 40 45 Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr His Tyr Asn Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Leu Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Tyr Cys 85 90 95 Thr Arg Ser Ser Tyr Tyr Tyr Asp Gly Ser Leu Phe Ala Asp Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro 130 135 140 Leu Ser Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Lys 145 150 155 160 Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp 165 170 175 Tyr Leu Gln Lys Pro Gly Gln Pro Pro Gln Leu Leu Ile Tyr Arg Val 180 185 190 Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser 195 200 205 Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val 210 215 220 Gly Val Tyr Tyr Cys Phe Gln Gly Ser Thr Leu Pro Phe Thr Phe Gly 225 230 235 240 Gln Gly Thr Lys Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val 245 250 255 Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 260 265 270 Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met 275 280 285 Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg 290 295 300 Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val 305 310 315 320 Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr 325 330 335 Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 340 345 350 Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr 355 360 365 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln 385 390 395 400 Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys 405 410 415 Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val 420 425 430 Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys 435 440 445 Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly 450 455 460 Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala 465 470 475 480 Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly 485 490 495 Gly Thr Lys Leu Thr Val Leu 500 <210> 151 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-16 <400> 151 Ser Tyr Trp Ile His 1 5 <210> 152 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-16 <400> 152 Ala Ile Tyr Pro Gly Asn Ser Asp Thr His Tyr Asn Gln Lys Phe Gln 1 5 10 15 Gly <210> 153 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-16 <400> 153 Ser Ser Tyr Tyr Tyr Asp Gly Ser Leu Phe Ala Asp 1 5 10 <210> 154 <211> 16 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-16 <400> 154 Lys Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Tyr 1 5 10 15 <210> 155 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-16 <400> 155 Arg Val Ser Asn Arg Phe Ser 1 5 <210> 156 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-16 <400> 156 Phe Gln Gly Ser His Leu Pro Phe Thr 1 5 <210> 157 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-16 <400> 157 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Thr 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Trp Ile His Trp Val Lys Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 35 40 45 Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr His Tyr Asn Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Leu Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Tyr Cys 85 90 95 Thr Arg Ser Ser Tyr Tyr Tyr Asp Gly Ser Leu Phe Ala Asp Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 158 <211> 112 <212> PRT <213> artificial <220> <223> VL de BCMA-16 <400> 158 Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 1 5 10 15 Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Ile Val His Ser 20 25 30 Asn Gly Asn Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Pro 35 40 45 Pro Gln Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 85 90 95 Ser His Leu Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 159 <211> 248 <212> PRT <213> artificial <220> <223> BCMA-16 scFv <400> 159 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Thr 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Trp Ile His Trp Val Lys Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 35 40 45 Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr His Tyr Asn Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Leu Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Tyr Cys 85 90 95 Thr Arg Ser Ser Tyr Tyr Tyr Asp Gly Ser Leu Phe Ala Asp Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro 130 135 140 Leu Ser Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Lys 145 150 155 160 Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp 165 170 175 Tyr Leu Gln Lys Pro Gly Gln Pro Pro Gln Leu Leu Ile Tyr Arg Val 180 185 190 Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser 195 200 205 Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val 210 215 220 Gly Val Tyr Tyr Cys Phe Gln Gly Ser His Leu Pro Phe Thr Phe Gly 225 230 235 240 Gln Gly Thr Lys Leu Glu Ile Lys 245 <210> 160 <211> 503 <212> PRT <213> artificial <220> <223> BCMA-16 HL x CD3 HL molécula biespecífica <400> 160 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Thr 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Trp Ile His Trp Val Lys Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 35 40 45 Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr His Tyr Asn Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Leu Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Tyr Cys 85 90 95 Thr Arg Ser Ser Tyr Tyr Tyr Asp Gly Ser Leu Phe Ala Asp Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro 130 135 140 Leu Ser Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Lys 145 150 155 160 Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp 165 170 175 Tyr Leu Gln Lys Pro Gly Gln Pro Pro Gln Leu Leu Ile Tyr Arg Val 180 185 190 Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser 195 200 205 Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val 210 215 220 Gly Val Tyr Tyr Cys Phe Gln Gly Ser His Leu Pro Phe Thr Phe Gly 225 230 235 240 Gln Gly Thr Lys Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val 245 250 255 Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 260 265 270 Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met 275 280 285 Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg 290 295 300 Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val 305 310 315 320 Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr 325 330 335 Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 340 345 350 Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr 355 360 365 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln 385 390 395 400 Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys 405 410 415 Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val 420 425 430 Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys 435 440 445 Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly 450 455 460 Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala 465 470 475 480 Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly 485 490 495 Gly Thr Lys Leu Thr Val Leu 500 <210> 161 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-17 <400> 161 Asn Phe Asp Met Ala 1 5 <210> 162 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-17 <400> 162 Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 163 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-17 <400> 163 His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr 1 5 10 <210> 164 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-17 <400> 164 Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 165 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-17 <400> 165 Tyr Thr Ser Asn Leu Gln Ser 1 5 <210> 166 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-17 <400> 166 Gln Gln Tyr Asp Ile Ser Ser Tyr Thr 1 5 <210> 167 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-17 <400> 167 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 168 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-17 <400> 168 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 35 40 45 Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Ile Ser Ser Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 169 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-17 scFv <400> 169 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Tyr Asp Ile Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu 225 230 235 240 Glu Ile Lys <210> 170 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-17 HL x CD3 HL molécula biespecífica <400> 170 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Tyr Asp Ile Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 171 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-18 <400> 171 Asn Phe Asp Met Ala 1 5 <210> 172 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-18 <400> 172 Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 173 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-18 <400> 173 His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr 1 5 10 <210> 174 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-18 <400> 174 Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 175 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-18 <400> 175 Tyr Thr Ser Asn Leu Gln Ser 1 5 <210> 176 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-18 <400> 176 Met Gly Gln Thr Ile Ser Ser Tyr Thr 1 5 <210> 177 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-18 <400> 177 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 178 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-18 <400> 178 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 35 40 45 Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Met Gly Gln Thr Ile Ser Ser Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 179 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-18 scFv <400> 179 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 210 215 220 Met Gly Gln Thr Ile Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu 225 230 235 240 Glu Ile Lys <210> 180 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-18 HL x CD3 HL molécula biespecífica <400> 180 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 210 215 220 Met Gly Gln Thr Ile Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 181 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-19 <400> 181 Asn Phe Asp Met Ala 1 5 <210> 182 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-19 <400> 182 Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 183 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-19 <400> 183 His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr 1 5 10 <210> 184 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-19 <400> 184 Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 185 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-19 <400> 185 Tyr Thr Ser Asn Leu Gln Ser 1 5 <210> 186 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-19 <400> 186 Gln Gln Tyr Asp Ile Ser Ser Tyr Thr 1 5 <210> 187 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-19 <400> 187 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 188 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-19 <400> 188 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 35 40 45 Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Ile Ser Ser Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 189 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-19 scFv <400> 189 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Tyr Asp Ile Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu 225 230 235 240 Glu Ile Lys <210> 190 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-19 HL x CD3 HL molécula biespecífica <400> 190 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Tyr Asp Ile Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 191 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-20 <400> 191 Asn Phe Asp Met Ala 1 5 <210> 192 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-20 <400> 192 Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 193 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-20 <400> 193 His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr 1 5 10 <210> 194 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-20 <400> 194 Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 195 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-20 <400> 195 Tyr Thr Ser Asn Leu Gln Ser 1 5 <210> 196 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-20 <400> 196 Met Gly Gln Thr Ile Ser Ser Tyr Thr 1 5 <210> 197 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-20 <400> 197 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 198 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-20 <400> 198 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 35 40 45 Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Met Gly Gln Thr Ile Ser Ser Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 199 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-20 scFv <400> 199 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 210 215 220 Met Gly Gln Thr Ile Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu 225 230 235 240 Glu Ile Lys <210> 200 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-20 HL x CD3 HL molécula biespecífica <400> 200 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 210 215 220 Met Gly Gln Thr Ile Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 201 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-21 <400> 201 Asn Phe Asp Met Ala 1 5 <210> 202 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-21 <400> 202 Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 203 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-21 <400> 203 His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr 1 5 10 <210> 204 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-21 <400> 204 Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 205 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-21 <400> 205 Tyr Thr Ser Asn Leu Gln Ser 1 5 <210> 206 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-21 <400> 206 Gln Gln Tyr Asp Ile Ser Ser Tyr Thr 1 5 <210> 207 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-21 <400> 207 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 208 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-21 <400> 208 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 35 40 45 Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Ile Ser Ser Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 209 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-21 scFv <400> 209 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Ser Cys Arg 145 150 155 160 Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Tyr Asp Ile Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu 225 230 235 240 Glu Ile Lys <210> 210 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-21 HL x CD3 HL molécula biespecífica <400> 210 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Ser Cys Arg 145 150 155 160 Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Tyr Asp Ile Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 211 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-22 <400> 211 Asn Phe Asp Met Ala 1 5 <210> 212 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-22 <400> 212 Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Glu Ser Val Lys 1 5 10 15 Gly <210> 213 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-22 <400> 213 His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr 1 5 10 <210> 214 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-22 <400> 214 Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 215 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-22 <400> 215 Tyr Thr Ser Asn Leu Gln Ser 1 5 <210> 216 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-22 <400> 216 Met Gly Gln Thr Ile Ser Ser Tyr Thr 1 5 <210> 217 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-22 <400> 217 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Glu Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 218 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-22 <400> 218 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 35 40 45 Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Met Gly Gln Thr Ile Ser Ser Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 219 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-22 scFv <400> 219 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Glu Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Ser Cys Arg 145 150 155 160 Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 210 215 220 Met Gly Gln Thr Ile Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu 225 230 235 240 Glu Ile Lys <210> 220 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-22 HL x CD3 HL molécula biespecífica <400> 220 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Glu Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Ser Cys Arg 145 150 155 160 Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 210 215 220 Met Gly Gln Thr Ile Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 221 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-23 <400> 221 Asn Phe Asp Met Ala 1 5 <210> 222 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-23 <400> 222 Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 223 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-23 <400> 223 His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr 1 5 10 <210> 224 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-23 <400> 224 Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 225 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-23 <400> 225 Tyr Thr Ser Asn Leu Gln Ser 1 5 <210> 226 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-23 <400> 226 Met Gly Gln Thr Ile Ser Ser Tyr Thr 1 5 <210> 227 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-23 <400> 227 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Ala Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 228 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-23 <400> 228 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 35 40 45 Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Met Gly Gln Thr Ile Ser Ser Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 229 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-23 scFv <400> 229 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Ala Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 210 215 220 Met Gly Gln Thr Ile Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu 225 230 235 240 Glu Ile Lys <210> 230 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-23 HL x CD3 HL molécula biespecífica <400> 230 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Ala Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Ala Asp His Ala Ile Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 210 215 220 Met Gly Gln Thr Ile Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 231 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-24 <400> 231 Asp Tyr Tyr Ile Asn 1 5 <210> 232 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-24 <400> 232 Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe Thr 1 5 10 15 Gly <210> 233 <211> 10 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-24 <400> 233 Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val 1 5 10 <210> 234 <211> 16 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-24 <400> 234 Lys Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 1 5 10 15 <210> 235 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-24 <400> 235 Lys Val Ser Asn Arg Phe Ser 1 5 <210> 236 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-24 <400> 236 Ala Glu Thr Ser His Val Pro Trp Thr 1 5 <210> 237 <211> 119 <212> PRT <213> artificial <220> <223> VH de BCMA-24 <400> 237 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser 115 <210> 238 <211> 112 <212> PRT <213> artificial <220> <223> VL de BCMA-24 <400> 238 Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 1 5 10 15 Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Val His Ser 20 25 30 Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Asn Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Glu Thr 85 90 95 Ser His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 239 <211> 246 <212> PRT <213> artificial <220> <223> BCMA-24 scFv <400> 239 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 130 135 140 Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser 145 150 155 160 Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 165 170 175 Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 180 185 190 Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 195 200 205 Asp Phe Thr Leu Lys Ile Asn Arg Val Glu Ala Glu Asp Val Gly Val 210 215 220 Tyr Tyr Cys Ala Glu Thr Ser His Val Pro Trp Thr Phe Gly Gln Gly 225 230 235 240 Thr Lys Leu Glu Ile Lys 245 <210> 240 <211> 501 <212> PRT <213> artificial <220> <223> BCMA-24 HL x CD3 HL molécula biespecífica <400> 240 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 130 135 140 Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser 145 150 155 160 Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 165 170 175 Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 180 185 190 Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 195 200 205 Asp Phe Thr Leu Lys Ile Asn Arg Val Glu Ala Glu Asp Val Gly Val 210 215 220 Tyr Tyr Cys Ala Glu Thr Ser His Val Pro Trp Thr Phe Gly Gln Gly 225 230 235 240 Thr Lys Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 245 250 255 Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu 260 265 270 Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp 275 280 285 Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg 290 295 300 Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp 305 310 315 320 Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln 325 330 335 Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg 340 345 350 His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly 355 360 365 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 370 375 380 Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro 385 390 395 400 Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser 405 410 415 Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln 420 425 430 Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu 435 440 445 Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 450 455 460 Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr 465 470 475 480 Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr 485 490 495 Lys Leu Thr Val Leu 500 <210> 241 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-25 <400> 241 Asp Tyr Tyr Ile Asn 1 5 <210> 242 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-25 <400> 242 Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe Thr 1 5 10 15 Gly <210> 243 <211> 10 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-25 <400> 243 Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val 1 5 10 <210> 244 <211> 16 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-25 <400> 244 Lys Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 1 5 10 15 <210> 245 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-25 <400> 245 Lys Val Ser Asn Arg Phe Ser 1 5 <210> 246 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-25 <400> 246 Leu Thr Thr Ser His Val Pro Trp Thr 1 5 <210> 247 <211> 119 <212> PRT <213> artificial <220> <223> VH de BCMA-25 <400> 247 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser 115 <210> 248 <211> 112 <212> PRT <213> artificial <220> <223> VL de BCMA-25 <400> 248 Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 1 5 10 15 Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Val His Ser 20 25 30 Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Asn Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Leu Thr Thr 85 90 95 Ser His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 249 <211> 246 <212> PRT <213> artificial <220> <223> BCMA-25 scFv <400> 249 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 130 135 140 Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser 145 150 155 160 Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 165 170 175 Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 180 185 190 Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 195 200 205 Asp Phe Thr Leu Lys Ile Asn Arg Val Glu Ala Glu Asp Val Gly Val 210 215 220 Tyr Tyr Cys Leu Thr Thr Ser His Val Pro Trp Thr Phe Gly Gln Gly 225 230 235 240 Thr Lys Leu Glu Ile Lys 245 <210> 250 <211> 501 <212> PRT <213> artificial <220> <223> BCMA-25 HL x CD3 HL molécula biespecífica <400> 250 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 130 135 140 Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser 145 150 155 160 Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 165 170 175 Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 180 185 190 Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 195 200 205 Asp Phe Thr Leu Lys Ile Asn Arg Val Glu Ala Glu Asp Val Gly Val 210 215 220 Tyr Tyr Cys Leu Thr Thr Ser His Val Pro Trp Thr Phe Gly Gln Gly 225 230 235 240 Thr Lys Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 245 250 255 Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu 260 265 270 Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp 275 280 285 Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg 290 295 300 Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp 305 310 315 320 Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln 325 330 335 Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg 340 345 350 His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly 355 360 365 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 370 375 380 Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro 385 390 395 400 Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser 405 410 415 Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln 420 425 430 Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu 435 440 445 Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 450 455 460 Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr 465 470 475 480 Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr 485 490 495 Lys Leu Thr Val Leu 500 <210> 251 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-26 <400> 251 Asp Tyr Tyr Ile Asn 1 5 <210> 252 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-26 <400> 252 Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe Thr 1 5 10 15 Gly <210> 253 <211> 10 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-26 <400> 253 Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val 1 5 10 <210> 254 <211> 16 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-26 <400> 254 Lys Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 1 5 10 15 <210> 255 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-26 <400> 255 Lys Val Ser Asn Arg Phe Ser 1 5 <210> 256 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-26 <400> 256 Ala Glu Thr Ser His Val Pro Trp Thr 1 5 <210> 257 <211> 119 <212> PRT <213> artificial <220> <223> VH de BCMA-26 <400> 257 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser 115 <210> 258 <211> 112 <212> PRT <213> artificial <220> <223> VL de BCMA-26 <400> 258 Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 1 5 10 15 Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Val His Ser 20 25 30 Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Glu Thr 85 90 95 Ser His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 259 <211> 246 <212> PRT <213> artificial <220> <223> BCMA-26 scFv <400> 259 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 130 135 140 Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser 145 150 155 160 Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 165 170 175 Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 180 185 190 Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 195 200 205 Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 210 215 220 Tyr Tyr Cys Ala Glu Thr Ser His Val Pro Trp Thr Phe Gly Gln Gly 225 230 235 240 Thr Lys Leu Glu Ile Lys 245 <210> 260 <211> 501 <212> PRT <213> artificial <220> <223> BCMA-26 HL x CD3 HL molécula biespecífica <400> 260 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 130 135 140 Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser 145 150 155 160 Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 165 170 175 Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 180 185 190 Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 195 200 205 Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 210 215 220 Tyr Tyr Cys Ala Glu Thr Ser His Val Pro Trp Thr Phe Gly Gln Gly 225 230 235 240 Thr Lys Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 245 250 255 Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu 260 265 270 Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp 275 280 285 Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg 290 295 300 Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp 305 310 315 320 Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln 325 330 335 Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg 340 345 350 His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly 355 360 365 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 370 375 380 Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro 385 390 395 400 Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser 405 410 415 Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln 420 425 430 Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu 435 440 445 Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 450 455 460 Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr 465 470 475 480 Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr 485 490 495 Lys Leu Thr Val Leu 500 <210> 261 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-27 <400> 261 Asp Tyr Tyr Ile Asn 1 5 <210> 262 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-27 <400> 262 Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe Thr 1 5 10 15 Gly <210> 263 <211> 10 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-27 <400> 263 Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val 1 5 10 <210> 264 <211> 16 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-27 <400> 264 Lys Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 1 5 10 15 <210> 265 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-27 <400> 265 Lys Val Ser Asn Arg Phe Ser 1 5 <210> 266 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-27 <400> 266 Leu Thr Thr Ser His Val Pro Trp Thr 1 5 <210> 267 <211> 119 <212> PRT <213> artificial <220> <223> VH de BCMA-27 <400> 267 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser 115 <210> 268 <211> 112 <212> PRT <213> artificial <220> <223> VL de BCMA-27 <400> 268 Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 1 5 10 15 Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Val His Ser 20 25 30 Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Leu Thr Thr 85 90 95 Ser His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 269 <211> 246 <212> PRT <213> artificial <220> <223> BCMA-27 scFv <400> 269 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 130 135 140 Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser 145 150 155 160 Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 165 170 175 Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 180 185 190 Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 195 200 205 Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 210 215 220 Tyr Tyr Cys Leu Thr Thr Ser His Val Pro Trp Thr Phe Gly Gln Gly 225 230 235 240 Thr Lys Leu Glu Ile Lys 245 <210> 270 <211> 501 <212> PRT <213> artificial <220> <223> BCMA-27 HL x CD3 HL molécula biespecífica <400> 270 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 130 135 140 Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser 145 150 155 160 Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 165 170 175 Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 180 185 190 Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 195 200 205 Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 210 215 220 Tyr Tyr Cys Leu Thr Thr Ser His Val Pro Trp Thr Phe Gly Gln Gly 225 230 235 240 Thr Lys Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 245 250 255 Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu 260 265 270 Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp 275 280 285 Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg 290 295 300 Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp 305 310 315 320 Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln 325 330 335 Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg 340 345 350 His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly 355 360 365 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 370 375 380 Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro 385 390 395 400 Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser 405 410 415 Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln 420 425 430 Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu 435 440 445 Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 450 455 460 Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr 465 470 475 480 Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr 485 490 495 Lys Leu Thr Val Leu 500 <210> 271 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-28 <400> 271 Asp Tyr Tyr Ile Asn 1 5 <210> 272 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-28 <400> 272 Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe Thr 1 5 10 15 Gly <210> 273 <211> 10 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-28 <400> 273 Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val 1 5 10 <210> 274 <211> 16 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-28 <400> 274 Lys Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 1 5 10 15 <210> 275 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-28 <400> 275 Lys Val Ser Asn Arg Phe Ser 1 5 <210> 276 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-28 <400> 276 Ala Glu Thr Ser His Val Pro Trp Thr 1 5 <210> 277 <211> 119 <212> PRT <213> artificial <220> <223> VH de BCMA-28 <400> 277 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser 115 <210> 278 <211> 112 <212> PRT <213> artificial <220> <223> VL de BCMA-28 <400> 278 Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Pro Gly 1 5 10 15 Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Val His Ser 20 25 30 Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Glu Thr 85 90 95 Ser His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 279 <211> 246 <212> PRT <213> artificial <220> <223> BCMA-28 scFv <400> 279 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 130 135 140 Leu Ser Val Ser Pro Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser 145 150 155 160 Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 165 170 175 Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 180 185 190 Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 195 200 205 Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 210 215 220 Tyr Tyr Cys Ala Glu Thr Ser His Val Pro Trp Thr Phe Gly Gln Gly 225 230 235 240 Thr Lys Leu Glu Ile Lys 245 <210> 280 <211> 501 <212> PRT <213> artificial <220> <223> BCMA-28 HL x CD3 HL molécula biespecífica <400> 280 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 130 135 140 Leu Ser Val Ser Pro Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser 145 150 155 160 Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 165 170 175 Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 180 185 190 Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 195 200 205 Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 210 215 220 Tyr Tyr Cys Ala Glu Thr Ser His Val Pro Trp Thr Phe Gly Gln Gly 225 230 235 240 Thr Lys Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 245 250 255 Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu 260 265 270 Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp 275 280 285 Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg 290 295 300 Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp 305 310 315 320 Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln 325 330 335 Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg 340 345 350 His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly 355 360 365 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 370 375 380 Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro 385 390 395 400 Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser 405 410 415 Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln 420 425 430 Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu 435 440 445 Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 450 455 460 Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr 465 470 475 480 Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr 485 490 495 Lys Leu Thr Val Leu 500 <210> 281 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-29 <400> 281 Asp Tyr Tyr Ile Asn 1 5 <210> 282 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-29 <400> 282 Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe Thr 1 5 10 15 Gly <210> 283 <211> 10 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-29 <400> 283 Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val 1 5 10 <210> 284 <211> 16 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-29 <400> 284 Lys Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 1 5 10 15 <210> 285 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-29 <400> 285 Lys Val Ser Asn Arg Phe Ser 1 5 <210> 286 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-29 <400> 286 Leu Thr Thr Ser His Val Pro Trp Thr 1 5 <210> 287 <211> 119 <212> PRT <213> artificial <220> <223> VH de BCMA-29 <400> 287 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser 115 <210> 288 <211> 112 <212> PRT <213> artificial <220> <223> VL de BCMA-29 <400> 288 Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Pro Gly 1 5 10 15 Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Val His Ser 20 25 30 Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Leu Thr Thr 85 90 95 Ser His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 289 <211> 246 <212> PRT <213> artificial <220> <223> BCMA-29 scFv <400> 289 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 130 135 140 Leu Ser Val Ser Pro Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser 145 150 155 160 Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 165 170 175 Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 180 185 190 Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 195 200 205 Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 210 215 220 Tyr Tyr Cys Leu Thr Thr Ser His Val Pro Trp Thr Phe Gly Gln Gly 225 230 235 240 Thr Lys Leu Glu Ile Lys 245 <210> 290 <211> 501 <212> PRT <213> artificial <220> <223> BCMA-29 HL x CD3 HL molécula biespecífica <400> 290 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 130 135 140 Leu Ser Val Ser Pro Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser 145 150 155 160 Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 165 170 175 Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 180 185 190 Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 195 200 205 Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 210 215 220 Tyr Tyr Cys Leu Thr Thr Ser His Val Pro Trp Thr Phe Gly Gln Gly 225 230 235 240 Thr Lys Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 245 250 255 Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu 260 265 270 Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp 275 280 285 Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg 290 295 300 Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp 305 310 315 320 Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln 325 330 335 Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg 340 345 350 His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly 355 360 365 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 370 375 380 Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro 385 390 395 400 Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser 405 410 415 Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln 420 425 430 Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu 435 440 445 Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 450 455 460 Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr 465 470 475 480 Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr 485 490 495 Lys Leu Thr Val Leu 500 <210> 291 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-30 <400> 291 Asp Tyr Tyr Ile Asn 1 5 <210> 292 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-30 <400> 292 Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe Thr 1 5 10 15 Gly <210> 293 <211> 10 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-30 <400> 293 Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val 1 5 10 <210> 294 <211> 16 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-30 <400> 294 Lys Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 1 5 10 15 <210> 295 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-30 <400> 295 Lys Val Ser Asn Arg Phe Ser 1 5 <210> 296 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-30 <400> 296 Ala Glu Thr Ser His Val Pro Trp Thr 1 5 <210> 297 <211> 119 <212> PRT <213> artificial <220> <223> VH de BCMA-30 <400> 297 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser 115 <210> 298 <211> 112 <212> PRT <213> artificial <220> <223> VL de BCMA-30 <400> 298 Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Val His Ser 20 25 30 Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Glu Thr 85 90 95 Ser His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 299 <211> 246 <212> PRT <213> artificial <220> <223> BCMA-30 scFv <400> 299 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 130 135 140 Leu Ser Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Lys Ser Ser 145 150 155 160 Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 165 170 175 Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 180 185 190 Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Ala 195 200 205 Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 210 215 220 Tyr Tyr Cys Ala Glu Thr Ser His Val Pro Trp Thr Phe Gly Gln Gly 225 230 235 240 Thr Lys Leu Glu Ile Lys 245 <210> 300 <211> 501 <212> PRT <213> artificial <220> <223> BCMA-30 HL x CD3 HL molécula biespecífica <400> 300 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 130 135 140 Leu Ser Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Lys Ser Ser 145 150 155 160 Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 165 170 175 Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 180 185 190 Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Ala 195 200 205 Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 210 215 220 Tyr Tyr Cys Ala Glu Thr Ser His Val Pro Trp Thr Phe Gly Gln Gly 225 230 235 240 Thr Lys Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 245 250 255 Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu 260 265 270 Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp 275 280 285 Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg 290 295 300 Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp 305 310 315 320 Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln 325 330 335 Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg 340 345 350 His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly 355 360 365 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 370 375 380 Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro 385 390 395 400 Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser 405 410 415 Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln 420 425 430 Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu 435 440 445 Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 450 455 460 Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr 465 470 475 480 Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr 485 490 495 Lys Leu Thr Val Leu 500 <210> 301 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-31 <400> 301 Asp Tyr Tyr Ile Asn 1 5 <210> 302 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-31 <400> 302 Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe Thr 1 5 10 15 Gly <210> 303 <211> 10 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-31 <400> 303 Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val 1 5 10 <210> 304 <211> 16 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-31 <400> 304 Lys Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 1 5 10 15 <210> 305 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-31 <400> 305 Lys Val Ser Asn Arg Phe Ser 1 5 <210> 306 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-31 <400> 306 Leu Thr Thr Ser His Val Pro Trp Thr 1 5 <210> 307 <211> 119 <212> PRT <213> artificial <220> <223> VH de BCMA-31 <400> 307 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser 115 <210> 308 <211> 112 <212> PRT <213> artificial <220> <223> VL de BCMA-31 <400> 308 Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Val His Ser 20 25 30 Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Leu Thr Thr 85 90 95 Ser His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 309 <211> 246 <212> PRT <213> artificial <220> <223> BCMA-31 scFv <400> 309 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 130 135 140 Leu Ser Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Lys Ser Ser 145 150 155 160 Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 165 170 175 Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 180 185 190 Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Ala 195 200 205 Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 210 215 220 Tyr Tyr Cys Leu Thr Thr Ser His Val Pro Trp Thr Phe Gly Gln Gly 225 230 235 240 Thr Lys Leu Glu Ile Lys 245 <210> 310 <211> 501 <212> PRT <213> artificial <220> <223> BCMA-31 HL x CD3 HL molécula biespecífica <400> 310 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 130 135 140 Leu Ser Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Lys Ser Ser 145 150 155 160 Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 165 170 175 Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 180 185 190 Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Ala 195 200 205 Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 210 215 220 Tyr Tyr Cys Leu Thr Thr Ser His Val Pro Trp Thr Phe Gly Gln Gly 225 230 235 240 Thr Lys Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 245 250 255 Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu 260 265 270 Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp 275 280 285 Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg 290 295 300 Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp 305 310 315 320 Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln 325 330 335 Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg 340 345 350 His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly 355 360 365 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 370 375 380 Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro 385 390 395 400 Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser 405 410 415 Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln 420 425 430 Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu 435 440 445 Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 450 455 460 Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr 465 470 475 480 Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr 485 490 495 Lys Leu Thr Val Leu 500 <210> 311 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-32 <400> 311 Asn His Ile Ile His 1 5 <210> 312 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-32 <400> 312 Tyr Ile Asn Pro Tyr Pro Gly Tyr His Ala Tyr Asn Glu Lys Phe Gln 1 5 10 15 Gly <210> 313 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-32 <400> 313 Asp Gly Tyr Tyr Arg Asp Thr Asp Val Leu Asp Tyr 1 5 10 <210> 314 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-32 <400> 314 Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 315 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-32 <400> 315 Tyr Thr Ser Arg Leu His Thr 1 5 <210> 316 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-32 <400> 316 Gln Gln Gly Asn Thr Leu Pro Trp Thr 1 5 <210> 317 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-32 <400> 317 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 20 25 30 Ile Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Tyr Ile Asn Pro Tyr Pro Gly Tyr His Ala Tyr Asn Glu Lys Phe 50 55 60 Gln Gly Arg Ala Thr Met Thr Ser Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Tyr Tyr Arg Asp Thr Asp Val Leu Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 318 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-32 <400> 318 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Tyr Thr Ser Arg Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Gln 65 70 75 80 Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 319 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-32 scFv <400> 319 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 20 25 30 Ile Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Tyr Ile Asn Pro Tyr Pro Gly Tyr His Ala Tyr Asn Glu Lys Phe 50 55 60 Gln Gly Arg Ala Thr Met Thr Ser Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Tyr Tyr Arg Asp Thr Asp Val Leu Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Thr Cys Gln 145 150 155 160 Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Thr 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 195 200 205 Phe Thr Ile Ser Ser Leu Gln Gln Glu Asp Ile Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 225 230 235 240 Glu Ile Lys <210> 320 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-32 HL x CD3 HL molécula biespecífica <400> 320 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 20 25 30 Ile Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Tyr Ile Asn Pro Tyr Pro Gly Tyr His Ala Tyr Asn Glu Lys Phe 50 55 60 Gln Gly Arg Ala Thr Met Thr Ser Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Tyr Tyr Arg Asp Thr Asp Val Leu Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Thr Cys Gln 145 150 155 160 Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Thr 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 195 200 205 Phe Thr Ile Ser Ser Leu Gln Gln Glu Asp Ile Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 321 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-33 <400> 321 Asn His Ile Ile His 1 5 <210> 322 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-33 <400> 322 Tyr Ile Asn Pro Tyr Asp Gly Trp Gly Asp Tyr Asn Glu Lys Phe Gln 1 5 10 15 Gly <210> 323 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-33 <400> 323 Asp Gly Tyr Tyr Arg Asp Ala Asp Val Leu Asp Tyr 1 5 10 <210> 324 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-33 <400> 324 Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 325 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-33 <400> 325 Tyr Thr Ser Arg Leu His Thr 1 5 <210> 326 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-33 <400> 326 Gln Gln Gly Asn Thr Leu Pro Trp Thr 1 5 <210> 327 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-33 <400> 327 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 20 25 30 Ile Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Tyr Ile Asn Pro Tyr Asp Gly Trp Gly Asp Tyr Asn Glu Lys Phe 50 55 60 Gln Gly Arg Ala Thr Met Thr Ser Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Tyr Tyr Arg Asp Ala Asp Val Leu Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 328 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-33 <400> 328 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Tyr Thr Ser Arg Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Gln 65 70 75 80 Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 329 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-33 scFv <400> 329 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 20 25 30 Ile Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Tyr Ile Asn Pro Tyr Asp Gly Trp Gly Asp Tyr Asn Glu Lys Phe 50 55 60 Gln Gly Arg Ala Thr Met Thr Ser Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Tyr Tyr Arg Asp Ala Asp Val Leu Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Thr Cys Gln 145 150 155 160 Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Thr 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 195 200 205 Phe Thr Ile Ser Ser Leu Gln Gln Glu Asp Ile Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 225 230 235 240 Glu Ile Lys <210> 330 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-33 HL x CD3 HL molécula biespecífica <400> 330 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 20 25 30 Ile Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Tyr Ile Asn Pro Tyr Asp Gly Trp Gly Asp Tyr Asn Glu Lys Phe 50 55 60 Gln Gly Arg Ala Thr Met Thr Ser Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Tyr Tyr Arg Asp Ala Asp Val Leu Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Thr Cys Gln 145 150 155 160 Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Thr 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 195 200 205 Phe Thr Ile Ser Ser Leu Gln Gln Glu Asp Ile Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 331 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-34 <400> 331 Asn His Ile Ile His 1 5 <210> 332 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-34 <400> 332 Tyr Ile Asn Pro Tyr Pro Gly Tyr His Ala Tyr Asn Glu Lys Phe Gln 1 5 10 15 Gly <210> 333 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-34 <400> 333 Asp Gly Tyr Tyr Arg Asp Thr Asp Val Leu Asp Tyr 1 5 10 <210> 334 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-34 <400> 334 Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 335 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-34 <400> 335 Tyr Thr Ser Arg Leu His Thr 1 5 <210> 336 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-34 <400> 336 Gln Gln Gly Asn Thr Leu Pro Trp Thr 1 5 <210> 337 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-34 <400> 337 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 20 25 30 Ile Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Tyr Ile Asn Pro Tyr Pro Gly Tyr His Ala Tyr Asn Glu Lys Phe 50 55 60 Gln Gly Arg Ala Thr Met Thr Ser Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Tyr Tyr Arg Asp Thr Asp Val Leu Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 338 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-34 <400> 338 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Tyr Thr Ser Arg Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 339 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-34 scFv <400> 339 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 20 25 30 Ile Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Tyr Ile Asn Pro Tyr Pro Gly Tyr His Ala Tyr Asn Glu Lys Phe 50 55 60 Gln Gly Arg Ala Thr Met Thr Ser Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Tyr Tyr Arg Asp Thr Asp Val Leu Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln 145 150 155 160 Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Thr 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 195 200 205 Phe Thr Ile Ser Ser Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 225 230 235 240 Glu Ile Lys <210> 340 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-34 HL x CD3 HL molécula biespecífica <400> 340 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 20 25 30 Ile Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Tyr Ile Asn Pro Tyr Pro Gly Tyr His Ala Tyr Asn Glu Lys Phe 50 55 60 Gln Gly Arg Ala Thr Met Thr Ser Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Tyr Tyr Arg Asp Thr Asp Val Leu Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln 145 150 155 160 Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Thr 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 195 200 205 Phe Thr Ile Ser Ser Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 341 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-35 <400> 341 Asn His Ile Ile His 1 5 <210> 342 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-35 <400> 342 Tyr Ile Asn Pro Tyr Asp Gly Trp Gly Asp Tyr Asn Glu Lys Phe Gln 1 5 10 15 Gly <210> 343 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-35 <400> 343 Asp Gly Tyr Tyr Arg Asp Ala Asp Val Leu Asp Tyr 1 5 10 <210> 344 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-35 <400> 344 Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 345 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-35 <400> 345 Tyr Thr Ser Arg Leu His Thr 1 5 <210> 346 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-35 <400> 346 Gln Gln Gly Asn Thr Leu Pro Trp Thr 1 5 <210> 347 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-35 <400> 347 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 20 25 30 Ile Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Tyr Ile Asn Pro Tyr Asp Gly Trp Gly Asp Tyr Asn Glu Lys Phe 50 55 60 Gln Gly Arg Ala Thr Met Thr Ser Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Tyr Tyr Arg Asp Ala Asp Val Leu Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 348 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-35 <400> 348 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Tyr Thr Ser Arg Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 349 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-35 scFv <400> 349 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 20 25 30 Ile Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Tyr Ile Asn Pro Tyr Asp Gly Trp Gly Asp Tyr Asn Glu Lys Phe 50 55 60 Gln Gly Arg Ala Thr Met Thr Ser Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Tyr Tyr Arg Asp Ala Asp Val Leu Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln 145 150 155 160 Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Thr 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 195 200 205 Phe Thr Ile Ser Ser Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 225 230 235 240 Glu Ile Lys <210> 350 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-35 HL x CD3 HL molécula biespecífica <400> 350 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 20 25 30 Ile Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Tyr Ile Asn Pro Tyr Asp Gly Trp Gly Asp Tyr Asn Glu Lys Phe 50 55 60 Gln Gly Arg Ala Thr Met Thr Ser Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Tyr Tyr Arg Asp Ala Asp Val Leu Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln 145 150 155 160 Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Thr 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 195 200 205 Phe Thr Ile Ser Ser Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 351 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-36 <400> 351 Asn His Ile Ile His 1 5 <210> 352 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-36 <400> 352 Tyr Ile Asn Pro Tyr Pro Gly Tyr His Ala Tyr Asn Gln Lys Phe Gln 1 5 10 15 Gly <210> 353 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-36 <400> 353 Asp Gly Tyr Tyr Arg Asp Thr Asp Val Leu Asp Tyr 1 5 10 <210> 354 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-36 <400> 354 Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 355 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-36 <400> 355 Tyr Thr Ser Arg Leu His Thr 1 5 <210> 356 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-36 <400> 356 Gln Gln Gly Asn Thr Leu Pro Trp Thr 1 5 <210> 357 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-36 <400> 357 Gln Val Gln Leu Val Gln Ser Gly Ala Lys Val Ile Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 20 25 30 Ile Ile His Trp Val Arg Gln Lys Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Tyr Ile Asn Pro Tyr Pro Gly Tyr His Ala Tyr Asn Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Lys Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Tyr Tyr Arg Asp Thr Asp Val Leu Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 358 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-36 <400> 358 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Tyr Thr Ser Arg Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Ser Phe Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 359 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-36 scFv <400> 359 Gln Val Gln Leu Val Gln Ser Gly Ala Lys Val Ile Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 20 25 30 Ile Ile His Trp Val Arg Gln Lys Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Tyr Ile Asn Pro Tyr Pro Gly Tyr His Ala Tyr Asn Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Lys Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Tyr Tyr Arg Asp Thr Asp Val Leu Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln 145 150 155 160 Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Arg Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Thr 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 195 200 205 Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 225 230 235 240 Glu Ile Lys <210> 360 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-36 HL x CD3 HL molécula biespecífica <400> 360 Gln Val Gln Leu Val Gln Ser Gly Ala Lys Val Ile Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 20 25 30 Ile Ile His Trp Val Arg Gln Lys Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Tyr Ile Asn Pro Tyr Pro Gly Tyr His Ala Tyr Asn Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Lys Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Tyr Tyr Arg Asp Thr Asp Val Leu Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln 145 150 155 160 Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Arg Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Thr 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 195 200 205 Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 361 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-37 <400> 361 Asn His Ile Ile His 1 5 <210> 362 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-37 <400> 362 Tyr Ile Asn Pro Tyr Asp Gly Trp Gly Asp Tyr Asn Gln Lys Phe Gln 1 5 10 15 Gly <210> 363 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-37 <400> 363 Asp Gly Tyr Tyr Arg Asp Ala Asp Val Leu Asp Tyr 1 5 10 <210> 364 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-37 <400> 364 Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 365 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-37 <400> 365 Tyr Thr Ser Arg Leu His Thr 1 5 <210> 366 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-37 <400> 366 Gln Gln Gly Asn Thr Leu Pro Trp Thr 1 5 <210> 367 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-37 <400> 367 Gln Val Gln Leu Val Gln Ser Gly Ala Lys Val Ile Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 20 25 30 Ile Ile His Trp Val Arg Gln Lys Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Tyr Ile Asn Pro Tyr Asp Gly Trp Gly Asp Tyr Asn Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Lys Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Tyr Tyr Arg Asp Ala Asp Val Leu Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 368 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-37 <400> 368 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Tyr Thr Ser Arg Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Ser Phe Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 369 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-37 scFv <400> 369 Gln Val Gln Leu Val Gln Ser Gly Ala Lys Val Ile Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 20 25 30 Ile Ile His Trp Val Arg Gln Lys Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Tyr Ile Asn Pro Tyr Asp Gly Trp Gly Asp Tyr Asn Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Lys Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Tyr Tyr Arg Asp Ala Asp Val Leu Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln 145 150 155 160 Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Arg Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Thr 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 195 200 205 Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 225 230 235 240 Glu Ile Lys <210> 370 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-37 HL x CD3 HL molécula biespecífica <400> 370 Gln Val Gln Leu Val Gln Ser Gly Ala Lys Val Ile Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 20 25 30 Ile Ile His Trp Val Arg Gln Lys Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Tyr Ile Asn Pro Tyr Asp Gly Trp Gly Asp Tyr Asn Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Lys Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Tyr Tyr Arg Asp Ala Asp Val Leu Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln 145 150 155 160 Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Arg Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Thr 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 195 200 205 Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 371 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-38 <400> 371 Asn His Ile Ile His 1 5 <210> 372 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-38 <400> 372 Tyr Ile Asn Pro Tyr Pro Gly Tyr His Ala Tyr Asn Gln Lys Phe Gln 1 5 10 15 Gly <210> 373 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-38 <400> 373 Asp Gly Tyr Tyr Arg Asp Thr Asp Val Leu Asp Tyr 1 5 10 <210> 374 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-38 <400> 374 Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 375 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-38 <400> 375 Tyr Thr Ser Arg Leu His Thr 1 5 <210> 376 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-38 <400> 376 Gln Gln Gly Asn Thr Leu Pro Trp Thr 1 5 <210> 377 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-38 <400> 377 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Ile Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 20 25 30 Ile Ile His Trp Val Arg Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Asn Pro Tyr Pro Gly Tyr His Ala Tyr Asn Gln Lys Phe 50 55 60 Gln Gly Lys Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Tyr Tyr Arg Asp Thr Asp Val Leu Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 378 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-38 <400> 378 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Tyr Thr Ser Arg Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Gln 65 70 75 80 Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 379 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-38 scFv <400> 379 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Ile Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 20 25 30 Ile Ile His Trp Val Arg Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Asn Pro Tyr Pro Gly Tyr His Ala Tyr Asn Gln Lys Phe 50 55 60 Gln Gly Lys Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Tyr Tyr Arg Asp Thr Asp Val Leu Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Thr Cys Gln 145 150 155 160 Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Thr 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 195 200 205 Phe Thr Ile Ser Ser Leu Gln Gln Glu Asp Ile Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 225 230 235 240 Glu Ile Lys <210> 380 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-38 HL x CD3 HL molécula biespecífica <400> 380 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Ile Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 20 25 30 Ile Ile His Trp Val Arg Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Asn Pro Tyr Pro Gly Tyr His Ala Tyr Asn Gln Lys Phe 50 55 60 Gln Gly Lys Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Tyr Tyr Arg Asp Thr Asp Val Leu Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Thr Cys Gln 145 150 155 160 Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Thr 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 195 200 205 Phe Thr Ile Ser Ser Leu Gln Gln Glu Asp Ile Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 381 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-39 <400> 381 Asn His Ile Ile His 1 5 <210> 382 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-39 <400> 382 Tyr Ile Asn Pro Tyr Asp Gly Trp Gly Asp Tyr Asn Gln Lys Phe Gln 1 5 10 15 Gly <210> 383 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-39 <400> 383 Asp Gly Tyr Tyr Arg Asp Ala Asp Val Leu Asp Tyr 1 5 10 <210> 384 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-39 <400> 384 Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 385 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-39 <400> 385 Tyr Thr Ser Arg Leu His Thr 1 5 <210> 386 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-39 <400> 386 Gln Gln Gly Asn Thr Leu Pro Trp Thr 1 5 <210> 387 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-39 <400> 387 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Ile Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 20 25 30 Ile Ile His Trp Val Arg Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Asn Pro Tyr Asp Gly Trp Gly Asp Tyr Asn Gln Lys Phe 50 55 60 Gln Gly Lys Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Tyr Tyr Arg Asp Ala Asp Val Leu Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 388 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-39 <400> 388 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Tyr Thr Ser Arg Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Gln 65 70 75 80 Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 389 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-39 scFv <400> 389 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Ile Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 20 25 30 Ile Ile His Trp Val Arg Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Asn Pro Tyr Asp Gly Trp Gly Asp Tyr Asn Gln Lys Phe 50 55 60 Gln Gly Lys Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Tyr Tyr Arg Asp Ala Asp Val Leu Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Thr Cys Gln 145 150 155 160 Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Thr 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 195 200 205 Phe Thr Ile Ser Ser Leu Gln Gln Glu Asp Ile Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 225 230 235 240 Glu Ile Lys <210> 390 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-39 HL x CD3 HL molécula biespecífica <400> 390 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Ile Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 20 25 30 Ile Ile His Trp Val Arg Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Asn Pro Tyr Asp Gly Trp Gly Asp Tyr Asn Gln Lys Phe 50 55 60 Gln Gly Lys Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Tyr Tyr Arg Asp Ala Asp Val Leu Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Thr Cys Gln 145 150 155 160 Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Thr 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 195 200 205 Phe Thr Ile Ser Ser Leu Gln Gln Glu Asp Ile Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 391 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-40 <400> 391 Asp Tyr Tyr Ile Asn 1 5 <210> 392 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-40 <400> 392 Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe Thr 1 5 10 15 Gly <210> 393 <211> 10 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-40 <400> 393 Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val 1 5 10 <210> 394 <211> 16 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-40 <400> 394 Lys Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 1 5 10 15 <210> 395 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-40 <400> 395 Lys Val Ser Asn Arg Phe Ser 1 5 <210> 396 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-40 <400> 396 Ser Gln Ser Ser Thr Ala Pro Trp Thr 1 5 <210> 397 <211> 119 <212> PRT <213> artificial <220> <223> VH de BCMA-40 <400> 397 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser 115 <210> 398 <211> 112 <212> PRT <213> artificial <220> <223> VL de BCMA-40 <400> 398 Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Leu Gly 1 5 10 15 Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Val His Ser 20 25 30 Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 85 90 95 Ser Thr Ala Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 399 <211> 246 <212> PRT <213> artificial <220> <223> BCMA-40 scFv <400> 399 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 130 135 140 Leu Pro Val Thr Leu Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser 145 150 155 160 Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 165 170 175 Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 180 185 190 Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 195 200 205 Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 210 215 220 Tyr Tyr Cys Ser Gln Ser Ser Thr Ala Pro Trp Thr Phe Gly Gln Gly 225 230 235 240 Thr Lys Leu Glu Ile Lys 245 <210> 400 <211> 501 <212> PRT <213> artificial <220> <223> BCMA-40 HL x CD3 HL molécula biespecífica <400> 400 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 130 135 140 Leu Pro Val Thr Leu Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser 145 150 155 160 Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 165 170 175 Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 180 185 190 Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 195 200 205 Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 210 215 220 Tyr Tyr Cys Ser Gln Ser Ser Thr Ala Pro Trp Thr Phe Gly Gln Gly 225 230 235 240 Thr Lys Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 245 250 255 Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu 260 265 270 Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp 275 280 285 Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg 290 295 300 Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp 305 310 315 320 Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln 325 330 335 Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg 340 345 350 His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly 355 360 365 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 370 375 380 Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro 385 390 395 400 Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser 405 410 415 Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln 420 425 430 Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu 435 440 445 Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 450 455 460 Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr 465 470 475 480 Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr 485 490 495 Lys Leu Thr Val Leu 500 <210> 401 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-41 <400> 401 Asp Tyr Tyr Ile Asn 1 5 <210> 402 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-41 <400> 402 Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe Thr 1 5 10 15 Gly <210> 403 <211> 10 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-41 <400> 403 Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val 1 5 10 <210> 404 <211> 16 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-41 <400> 404 Lys Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 1 5 10 15 <210> 405 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-41 <400> 405 Lys Val Ser Asn Arg Phe Ser 1 5 <210> 406 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-41 <400> 406 Ser Gln Ser Ser Ile Tyr Pro Trp Thr 1 5 <210> 407 <211> 119 <212> PRT <213> artificial <220> <223> VH de BCMA-41 <400> 407 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser 115 <210> 408 <211> 112 <212> PRT <213> artificial <220> <223> VL de BCMA-41 <400> 408 Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Leu Gly 1 5 10 15 Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Val His Ser 20 25 30 Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 85 90 95 Ser Ile Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 409 <211> 246 <212> PRT <213> artificial <220> <223> BCMA-41 scFv <400> 409 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 130 135 140 Leu Pro Val Thr Leu Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser 145 150 155 160 Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 165 170 175 Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 180 185 190 Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 195 200 205 Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 210 215 220 Tyr Tyr Cys Ser Gln Ser Ser Ile Tyr Pro Trp Thr Phe Gly Gln Gly 225 230 235 240 Thr Lys Leu Glu Ile Lys 245 <210> 410 <211> 501 <212> PRT <213> artificial <220> <223> BCMA-41 HL x CD3 HL molécula biespecífica <400> 410 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 130 135 140 Leu Pro Val Thr Leu Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser 145 150 155 160 Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 165 170 175 Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 180 185 190 Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 195 200 205 Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 210 215 220 Tyr Tyr Cys Ser Gln Ser Ser Ile Tyr Pro Trp Thr Phe Gly Gln Gly 225 230 235 240 Thr Lys Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 245 250 255 Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu 260 265 270 Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp 275 280 285 Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg 290 295 300 Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp 305 310 315 320 Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln 325 330 335 Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg 340 345 350 His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly 355 360 365 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 370 375 380 Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro 385 390 395 400 Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser 405 410 415 Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln 420 425 430 Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu 435 440 445 Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 450 455 460 Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr 465 470 475 480 Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr 485 490 495 Lys Leu Thr Val Leu 500 <210> 411 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-42 <400> 411 Asp Tyr Tyr Ile Asn 1 5 <210> 412 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-42 <400> 412 Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe Thr 1 5 10 15 Gly <210> 413 <211> 10 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-42 <400> 413 Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val 1 5 10 <210> 414 <211> 16 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-42 <400> 414 Lys Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 1 5 10 15 <210> 415 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-42 <400> 415 Lys Val Ser Asn Arg Phe Ser 1 5 <210> 416 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-42 <400> 416 Ser Gln Ser Thr Tyr Pro Glu Phe Thr 1 5 <210> 417 <211> 119 <212> PRT <213> artificial <220> <223> VH de BCMA-42 <400> 417 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser 115 <210> 418 <211> 112 <212> PRT <213> artificial <220> <223> VL de BCMA-42 <400> 418 Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Leu Gly 1 5 10 15 Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Val His Ser 20 25 30 Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 85 90 95 Thr Tyr Pro Glu Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 419 <211> 246 <212> PRT <213> artificial <220> <223> BCMA-42 scFv <400> 419 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 130 135 140 Leu Pro Val Thr Leu Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser 145 150 155 160 Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 165 170 175 Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 180 185 190 Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 195 200 205 Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 210 215 220 Tyr Tyr Cys Ser Gln Ser Thr Tyr Pro Glu Phe Thr Phe Gly Gln Gly 225 230 235 240 Thr Lys Leu Glu Ile Lys 245 <210> 420 <211> 501 <212> PRT <213> artificial <220> <223> BCMA-42 HL x CD3 HL molécula biespecífica <400> 420 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 130 135 140 Leu Pro Val Thr Leu Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser 145 150 155 160 Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 165 170 175 Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 180 185 190 Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 195 200 205 Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 210 215 220 Tyr Tyr Cys Ser Gln Ser Thr Tyr Pro Glu Phe Thr Phe Gly Gln Gly 225 230 235 240 Thr Lys Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 245 250 255 Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu 260 265 270 Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp 275 280 285 Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg 290 295 300 Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp 305 310 315 320 Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln 325 330 335 Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg 340 345 350 His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly 355 360 365 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 370 375 380 Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro 385 390 395 400 Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser 405 410 415 Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln 420 425 430 Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu 435 440 445 Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 450 455 460 Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr 465 470 475 480 Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr 485 490 495 Lys Leu Thr Val Leu 500 <210> 421 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-43 <400> 421 Asp Tyr Tyr Ile Asn 1 5 <210> 422 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-43 <400> 422 Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe Thr 1 5 10 15 Gly <210> 423 <211> 10 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-43 <400> 423 Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val 1 5 10 <210> 424 <211> 16 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-43 <400> 424 Lys Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 1 5 10 15 <210> 425 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-43 <400> 425 Lys Val Ser Asn Arg Phe Ser 1 5 <210> 426 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-43 <400> 426 Ser Gln Ser Ser Thr Ala Pro Trp Thr 1 5 <210> 427 <211> 119 <212> PRT <213> artificial <220> <223> VH de BCMA-43 <400> 427 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser 115 <210> 428 <211> 112 <212> PRT <213> artificial <220> <223> VL de BCMA-43 <400> 428 Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 1 5 10 15 Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Val His Ser 20 25 30 Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 85 90 95 Ser Thr Ala Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 429 <211> 246 <212> PRT <213> artificial <220> <223> BCMA-43 scFv <400> 429 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 130 135 140 Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser 145 150 155 160 Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 165 170 175 Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 180 185 190 Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 195 200 205 Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 210 215 220 Tyr Tyr Cys Ser Gln Ser Ser Thr Ala Pro Trp Thr Phe Gly Gln Gly 225 230 235 240 Thr Lys Leu Glu Ile Lys 245 <210> 430 <211> 501 <212> PRT <213> artificial <220> <223> BCMA-43 HL x CD3 HL molécula biespecífica <400> 430 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 130 135 140 Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser 145 150 155 160 Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 165 170 175 Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 180 185 190 Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 195 200 205 Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 210 215 220 Tyr Tyr Cys Ser Gln Ser Ser Thr Ala Pro Trp Thr Phe Gly Gln Gly 225 230 235 240 Thr Lys Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 245 250 255 Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu 260 265 270 Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp 275 280 285 Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg 290 295 300 Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp 305 310 315 320 Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln 325 330 335 Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg 340 345 350 His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly 355 360 365 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 370 375 380 Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro 385 390 395 400 Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser 405 410 415 Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln 420 425 430 Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu 435 440 445 Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 450 455 460 Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr 465 470 475 480 Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr 485 490 495 Lys Leu Thr Val Leu 500 <210> 431 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-44 <400> 431 Asp Tyr Tyr Ile Asn 1 5 <210> 432 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-44 <400> 432 Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe Thr 1 5 10 15 Gly <210> 433 <211> 10 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-44 <400> 433 Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val 1 5 10 <210> 434 <211> 16 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-44 <400> 434 Lys Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 1 5 10 15 <210> 435 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-44 <400> 435 Lys Val Ser Asn Arg Phe Ser 1 5 <210> 436 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-44 <400> 436 Ser Gln Ser Ser Ile Tyr Pro Trp Thr 1 5 <210> 437 <211> 119 <212> PRT <213> artificial <220> <223> VH de BCMA-44 <400> 437 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser 115 <210> 438 <211> 112 <212> PRT <213> artificial <220> <223> VL de BCMA-44 <400> 438 Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 1 5 10 15 Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Val His Ser 20 25 30 Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 85 90 95 Ser Ile Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 439 <211> 246 <212> PRT <213> artificial <220> <223> BCMA-44 scFv <400> 439 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 130 135 140 Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser 145 150 155 160 Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 165 170 175 Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 180 185 190 Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 195 200 205 Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 210 215 220 Tyr Tyr Cys Ser Gln Ser Ser Ile Tyr Pro Trp Thr Phe Gly Gln Gly 225 230 235 240 Thr Lys Leu Glu Ile Lys 245 <210> 440 <211> 501 <212> PRT <213> artificial <220> <223> BCMA-44 HL x CD3 HL molécula biespecífica <400> 440 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 130 135 140 Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser 145 150 155 160 Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 165 170 175 Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 180 185 190 Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 195 200 205 Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 210 215 220 Tyr Tyr Cys Ser Gln Ser Ser Ile Tyr Pro Trp Thr Phe Gly Gln Gly 225 230 235 240 Thr Lys Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 245 250 255 Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu 260 265 270 Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp 275 280 285 Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg 290 295 300 Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp 305 310 315 320 Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln 325 330 335 Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg 340 345 350 His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly 355 360 365 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 370 375 380 Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro 385 390 395 400 Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser 405 410 415 Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln 420 425 430 Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu 435 440 445 Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 450 455 460 Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr 465 470 475 480 Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr 485 490 495 Lys Leu Thr Val Leu 500 <210> 441 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-45 <400> 441 Asp Tyr Tyr Ile Asn 1 5 <210> 442 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-45 <400> 442 Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe Thr 1 5 10 15 Gly <210> 443 <211> 10 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-45 <400> 443 Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val 1 5 10 <210> 444 <211> 16 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-45 <400> 444 Lys Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 1 5 10 15 <210> 445 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-45 <400> 445 Lys Val Ser Asn Arg Phe Ser 1 5 <210> 446 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-45 <400> 446 Ser Gln Ser Thr Tyr Pro Glu Phe Thr 1 5 <210> 447 <211> 119 <212> PRT <213> artificial <220> <223> VH de BCMA-45 <400> 447 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser 115 <210> 448 <211> 112 <212> PRT <213> artificial <220> <223> VL de BCMA-45 <400> 448 Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 1 5 10 15 Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Val His Ser 20 25 30 Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 85 90 95 Thr Tyr Pro Glu Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 449 <211> 246 <212> PRT <213> artificial <220> <223> BCMA-45 scFv <400> 449 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 130 135 140 Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser 145 150 155 160 Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 165 170 175 Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 180 185 190 Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 195 200 205 Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 210 215 220 Tyr Tyr Cys Ser Gln Ser Thr Tyr Pro Glu Phe Thr Phe Gly Gln Gly 225 230 235 240 Thr Lys Leu Glu Ile Lys 245 <210> 450 <211> 501 <212> PRT <213> artificial <220> <223> BCMA-45 HL x CD3 HL molécula biespecífica <400> 450 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 130 135 140 Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser 145 150 155 160 Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 165 170 175 Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 180 185 190 Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 195 200 205 Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 210 215 220 Tyr Tyr Cys Ser Gln Ser Thr Tyr Pro Glu Phe Thr Phe Gly Gln Gly 225 230 235 240 Thr Lys Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 245 250 255 Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu 260 265 270 Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp 275 280 285 Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg 290 295 300 Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp 305 310 315 320 Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln 325 330 335 Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg 340 345 350 His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly 355 360 365 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 370 375 380 Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro 385 390 395 400 Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser 405 410 415 Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln 420 425 430 Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu 435 440 445 Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 450 455 460 Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr 465 470 475 480 Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr 485 490 495 Lys Leu Thr Val Leu 500 <210> 451 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-46 <400> 451 Asp Tyr Tyr Ile Asn 1 5 <210> 452 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-46 <400> 452 Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Glu Lys Phe Thr 1 5 10 15 Gly <210> 453 <211> 10 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-46 <400> 453 Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val 1 5 10 <210> 454 <211> 16 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-46 <400> 454 Lys Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 1 5 10 15 <210> 455 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-46 <400> 455 Lys Val Ser Asn Arg Phe Ser 1 5 <210> 456 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-46 <400> 456 Ser Gln Ser Ser Thr Ala Pro Trp Thr 1 5 <210> 457 <211> 119 <212> PRT <213> artificial <220> <223> VH de BCMA-46 <400> 457 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Glu Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser 115 <210> 458 <211> 112 <212> PRT <213> artificial <220> <223> VL de BCMA-46 <400> 458 Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Leu Gly 1 5 10 15 Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Val His Ser 20 25 30 Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 85 90 95 Ser Thr Ala Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 459 <211> 246 <212> PRT <213> artificial <220> <223> BCMA-46 scFv <400> 459 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Glu Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 130 135 140 Leu Ser Val Ser Leu Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser 145 150 155 160 Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 165 170 175 Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 180 185 190 Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 195 200 205 Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 210 215 220 Tyr Tyr Cys Ser Gln Ser Ser Thr Ala Pro Trp Thr Phe Gly Gln Gly 225 230 235 240 Thr Lys Leu Glu Ile Lys 245 <210> 460 <211> 501 <212> PRT <213> artificial <220> <223> BCMA-46 HL x CD3 HL molécula biespecífica <400> 460 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Glu Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 130 135 140 Leu Ser Val Ser Leu Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser 145 150 155 160 Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 165 170 175 Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 180 185 190 Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 195 200 205 Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 210 215 220 Tyr Tyr Cys Ser Gln Ser Ser Thr Ala Pro Trp Thr Phe Gly Gln Gly 225 230 235 240 Thr Lys Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 245 250 255 Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu 260 265 270 Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp 275 280 285 Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg 290 295 300 Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp 305 310 315 320 Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln 325 330 335 Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg 340 345 350 His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly 355 360 365 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 370 375 380 Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro 385 390 395 400 Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser 405 410 415 Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln 420 425 430 Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu 435 440 445 Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 450 455 460 Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr 465 470 475 480 Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr 485 490 495 Lys Leu Thr Val Leu 500 <210> 461 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-47 <400> 461 Asp Tyr Tyr Ile Asn 1 5 <210> 462 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-47 <400> 462 Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Glu Lys Phe Thr 1 5 10 15 Gly <210> 463 <211> 10 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-47 <400> 463 Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val 1 5 10 <210> 464 <211> 16 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-47 <400> 464 Lys Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 1 5 10 15 <210> 465 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-47 <400> 465 Lys Val Ser Asn Arg Phe Ser 1 5 <210> 466 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-47 <400> 466 Ser Gln Ser Ser Ile Tyr Pro Trp Thr 1 5 <210> 467 <211> 119 <212> PRT <213> artificial <220> <223> VH de BCMA-47 <400> 467 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Glu Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser 115 <210> 468 <211> 112 <212> PRT <213> artificial <220> <223> VL de BCMA-47 <400> 468 Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Leu Gly 1 5 10 15 Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Val His Ser 20 25 30 Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 85 90 95 Ser Ile Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 469 <211> 246 <212> PRT <213> artificial <220> <223> BCMA-47 scFv <400> 469 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Glu Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 130 135 140 Leu Ser Val Ser Leu Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser 145 150 155 160 Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 165 170 175 Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 180 185 190 Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 195 200 205 Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 210 215 220 Tyr Tyr Cys Ser Gln Ser Ser Ile Tyr Pro Trp Thr Phe Gly Gln Gly 225 230 235 240 Thr Lys Leu Glu Ile Lys 245 <210> 470 <211> 501 <212> PRT <213> artificial <220> <223> BCMA-47 HL x CD3 HL molécula biespecífica <400> 470 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Glu Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 130 135 140 Leu Ser Val Ser Leu Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser 145 150 155 160 Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 165 170 175 Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 180 185 190 Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 195 200 205 Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 210 215 220 Tyr Tyr Cys Ser Gln Ser Ser Ile Tyr Pro Trp Thr Phe Gly Gln Gly 225 230 235 240 Thr Lys Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 245 250 255 Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu 260 265 270 Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp 275 280 285 Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg 290 295 300 Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp 305 310 315 320 Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln 325 330 335 Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg 340 345 350 His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly 355 360 365 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 370 375 380 Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro 385 390 395 400 Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser 405 410 415 Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln 420 425 430 Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu 435 440 445 Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 450 455 460 Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr 465 470 475 480 Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr 485 490 495 Lys Leu Thr Val Leu 500 <210> 471 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-48 <400> 471 Asp Tyr Tyr Ile Asn 1 5 <210> 472 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-48 <400> 472 Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Glu Lys Phe Thr 1 5 10 15 Gly <210> 473 <211> 10 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-48 <400> 473 Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val 1 5 10 <210> 474 <211> 16 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-48 <400> 474 Lys Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 1 5 10 15 <210> 475 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-48 <400> 475 Lys Val Ser Asn Arg Phe Ser 1 5 <210> 476 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-48 <400> 476 Ser Gln Ser Thr Tyr Pro Glu Phe Thr 1 5 <210> 477 <211> 119 <212> PRT <213> artificial <220> <223> VH de BCMA-48 <400> 477 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Glu Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser 115 <210> 478 <211> 112 <212> PRT <213> artificial <220> <223> VL de BCMA-48 <400> 478 Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Leu Gly 1 5 10 15 Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Val His Ser 20 25 30 Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 85 90 95 Thr Tyr Pro Glu Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 479 <211> 246 <212> PRT <213> artificial <220> <223> BCMA-48 scFv <400> 479 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Glu Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 130 135 140 Leu Ser Val Ser Leu Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser 145 150 155 160 Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 165 170 175 Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 180 185 190 Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 195 200 205 Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 210 215 220 Tyr Tyr Cys Ser Gln Ser Thr Tyr Pro Glu Phe Thr Phe Gly Gln Gly 225 230 235 240 Thr Lys Leu Glu Ile Lys 245 <210> 480 <211> 501 <212> PRT <213> artificial <220> <223> BCMA-48 HL x CD3 HL molécula biespecífica <400> 480 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Glu Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 130 135 140 Leu Ser Val Ser Leu Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser 145 150 155 160 Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 165 170 175 Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 180 185 190 Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 195 200 205 Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 210 215 220 Tyr Tyr Cys Ser Gln Ser Thr Tyr Pro Glu Phe Thr Phe Gly Gln Gly 225 230 235 240 Thr Lys Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 245 250 255 Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu 260 265 270 Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp 275 280 285 Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg 290 295 300 Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp 305 310 315 320 Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln 325 330 335 Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg 340 345 350 His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly 355 360 365 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 370 375 380 Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro 385 390 395 400 Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser 405 410 415 Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln 420 425 430 Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu 435 440 445 Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 450 455 460 Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr 465 470 475 480 Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr 485 490 495 Lys Leu Thr Val Leu 500 <210> 481 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-49 <400> 481 Asp Tyr Tyr Ile Asn 1 5 <210> 482 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-49 <400> 482 Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe Thr 1 5 10 15 Gly <210> 483 <211> 10 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-49 <400> 483 Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val 1 5 10 <210> 484 <211> 16 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-49 <400> 484 Lys Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 1 5 10 15 <210> 485 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-49 <400> 485 Lys Val Ser Asn Arg Phe Ser 1 5 <210> 486 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-49 <400> 486 Ser Gln Ser Ser Thr Ala Pro Trp Thr 1 5 <210> 487 <211> 119 <212> PRT <213> artificial <220> <223> VH de BCMA-49 <400> 487 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Asn Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser 115 <210> 488 <211> 112 <212> PRT <213> artificial <220> <223> VL de BCMA-49 <400> 488 Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 1 5 10 15 Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Val His Ser 20 25 30 Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Ser Gln Ser 85 90 95 Ser Thr Ala Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 489 <211> 246 <212> PRT <213> artificial <220> <223> BCMA-49 scFv <400> 489 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Asn Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 130 135 140 Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser 145 150 155 160 Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 165 170 175 Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 180 185 190 Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 195 200 205 Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Ile 210 215 220 Tyr Tyr Cys Ser Gln Ser Ser Thr Ala Pro Trp Thr Phe Gly Gln Gly 225 230 235 240 Thr Lys Leu Glu Ile Lys 245 <210> 490 <211> 501 <212> PRT <213> artificial <220> <223> BCMA-49 HL x CD3 HL molécula biespecífica <400> 490 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Asn Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 130 135 140 Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser 145 150 155 160 Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 165 170 175 Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 180 185 190 Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 195 200 205 Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Ile 210 215 220 Tyr Tyr Cys Ser Gln Ser Ser Thr Ala Pro Trp Thr Phe Gly Gln Gly 225 230 235 240 Thr Lys Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 245 250 255 Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu 260 265 270 Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp 275 280 285 Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg 290 295 300 Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp 305 310 315 320 Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln 325 330 335 Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg 340 345 350 His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly 355 360 365 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 370 375 380 Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro 385 390 395 400 Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser 405 410 415 Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln 420 425 430 Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu 435 440 445 Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 450 455 460 Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr 465 470 475 480 Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr 485 490 495 Lys Leu Thr Val Leu 500 <210> 491 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-50 <400> 491 Asp Tyr Tyr Ile Asn 1 5 <210> 492 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-50 <400> 492 Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe Thr 1 5 10 15 Gly <210> 493 <211> 10 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-50 <400> 493 Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val 1 5 10 <210> 494 <211> 16 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-50 <400> 494 Lys Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 1 5 10 15 <210> 495 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-50 <400> 495 Lys Val Ser Asn Arg Phe Ser 1 5 <210> 496 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-50 <400> 496 Ser Gln Ser Ser Ile Tyr Pro Trp Thr 1 5 <210> 497 <211> 119 <212> PRT <213> artificial <220> <223> VH de BCMA-50 <400> 497 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Asn Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser 115 <210> 498 <211> 112 <212> PRT <213> artificial <220> <223> VL de BCMA-50 <400> 498 Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 1 5 10 15 Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Val His Ser 20 25 30 Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Ser Gln Ser 85 90 95 Ser Ile Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 499 <211> 246 <212> PRT <213> artificial <220> <223> BCMA-50 scFv <400> 499 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Asn Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 130 135 140 Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser 145 150 155 160 Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 165 170 175 Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 180 185 190 Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 195 200 205 Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Ile 210 215 220 Tyr Tyr Cys Ser Gln Ser Ser Ile Tyr Pro Trp Thr Phe Gly Gln Gly 225 230 235 240 Thr Lys Leu Glu Ile Lys 245 <210> 500 <211> 501 <212> PRT <213> artificial <220> <223> BCMA-50 HL x CD3 HL molécula biespecífica <400> 500 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Asn Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 130 135 140 Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser 145 150 155 160 Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 165 170 175 Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 180 185 190 Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 195 200 205 Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Ile 210 215 220 Tyr Tyr Cys Ser Gln Ser Ser Ile Tyr Pro Trp Thr Phe Gly Gln Gly 225 230 235 240 Thr Lys Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 245 250 255 Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu 260 265 270 Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp 275 280 285 Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg 290 295 300 Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp 305 310 315 320 Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln 325 330 335 Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg 340 345 350 His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly 355 360 365 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 370 375 380 Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro 385 390 395 400 Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser 405 410 415 Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln 420 425 430 Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu 435 440 445 Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 450 455 460 Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr 465 470 475 480 Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr 485 490 495 Lys Leu Thr Val Leu 500 <210> 501 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-51 <400> 501 Asp Tyr Tyr Ile Asn 1 5 <210> 502 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-51 <400> 502 Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe Thr 1 5 10 15 Gly <210> 503 <211> 10 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-51 <400> 503 Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val 1 5 10 <210> 504 <211> 16 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-51 <400> 504 Lys Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 1 5 10 15 <210> 505 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-51 <400> 505 Lys Val Ser Asn Arg Phe Ser 1 5 <210> 506 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-51 <400> 506 Ser Gln Ser Thr Tyr Pro Glu Phe Thr 1 5 <210> 507 <211> 119 <212> PRT <213> artificial <220> <223> VH de BCMA-51 <400> 507 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Asn Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser 115 <210> 508 <211> 112 <212> PRT <213> artificial <220> <223> VL de BCMA-51 <400> 508 Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 1 5 10 15 Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Val His Ser 20 25 30 Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Ser Gln Ser 85 90 95 Thr Tyr Pro Glu Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 509 <211> 246 <212> PRT <213> artificial <220> <223> BCMA-51 scFv <400> 509 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Asn Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 130 135 140 Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser 145 150 155 160 Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 165 170 175 Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 180 185 190 Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 195 200 205 Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Ile 210 215 220 Tyr Tyr Cys Ser Gln Ser Thr Tyr Pro Glu Phe Thr Phe Gly Gln Gly 225 230 235 240 Thr Lys Leu Glu Ile Lys 245 <210> 510 <211> 501 <212> PRT <213> artificial <220> <223> BCMA-51 HL x CD3 HL molécula biespecífica <400> 510 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 50 55 60 Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Asn Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 130 135 140 Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser 145 150 155 160 Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 165 170 175 Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 180 185 190 Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 195 200 205 Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Ile 210 215 220 Tyr Tyr Cys Ser Gln Ser Thr Tyr Pro Glu Phe Thr Phe Gly Gln Gly 225 230 235 240 Thr Lys Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 245 250 255 Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu 260 265 270 Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp 275 280 285 Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg 290 295 300 Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp 305 310 315 320 Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln 325 330 335 Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg 340 345 350 His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly 355 360 365 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 370 375 380 Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro 385 390 395 400 Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser 405 410 415 Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln 420 425 430 Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu 435 440 445 Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 450 455 460 Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr 465 470 475 480 Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr 485 490 495 Lys Leu Thr Val Leu 500 <210> 511 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-52 <400> 511 Asn Ala Trp Met Asp 1 5 <210> 512 <211> 19 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-52 <400> 512 Gln Ile Thr Ala Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Glu Pro 1 5 10 15 Val Lys Gly <210> 513 <211> 4 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-52 <400> 513 Asp Gly Tyr His 1 <210> 514 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-52 <400> 514 Arg Ala Ser Glu Asp Ile Arg Asn Gly Leu Ala 1 5 10 <210> 515 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-52 <400> 515 Asn Ala Asn Ser Leu His Thr 1 5 <210> 516 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-52 <400> 516 Glu Asp Thr Ser Lys Tyr Pro Tyr Thr 1 5 <210> 517 <211> 115 <212> PRT <213> artificial <220> <223> VH de BCMA-52 <400> 517 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 20 25 30 Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 35 40 45 Ala Gln Ile Thr Ala Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Glu 50 55 60 Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Thr Asp Asp Gly Tyr His Trp Gly Gln Gly Thr Leu Val Thr 100 105 110 Val Ser Ser 115 <210> 518 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-52 <400> 518 Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Glu Thr Val Thr Ile Ala Cys Arg Ala Ser Glu Asp Ile Arg Asn Gly 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asn Ala Asn Ser Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Lys Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Glu Ala Thr Tyr Tyr Cys Glu Asp Thr Ser Lys Tyr Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 519 <211> 237 <212> PRT <213> artificial <220> <223> BCMA-52 scFv <400> 519 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 20 25 30 Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 35 40 45 Ala Gln Ile Thr Ala Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Glu 50 55 60 Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Thr Asp Asp Gly Tyr His Trp Gly Gln Gly Thr Leu Val Thr 100 105 110 Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 130 135 140 Val Gly Glu Thr Val Thr Ile Ala Cys Arg Ala Ser Glu Asp Ile Arg 145 150 155 160 Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 165 170 175 Leu Ile Tyr Asn Ala Asn Ser Leu His Thr Gly Val Pro Ser Arg Phe 180 185 190 Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Lys Ile Ser Ser Leu 195 200 205 Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys Glu Asp Thr Ser Lys Tyr 210 215 220 Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 225 230 235 <210> 520 <211> 492 <212> PRT <213> artificial <220> <223> BCMA-52 HL x CD3 HL molécula biespecífica <400> 520 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 20 25 30 Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 35 40 45 Ala Gln Ile Thr Ala Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Glu 50 55 60 Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Thr Asp Asp Gly Tyr His Trp Gly Gln Gly Thr Leu Val Thr 100 105 110 Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 130 135 140 Val Gly Glu Thr Val Thr Ile Ala Cys Arg Ala Ser Glu Asp Ile Arg 145 150 155 160 Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 165 170 175 Leu Ile Tyr Asn Ala Asn Ser Leu His Thr Gly Val Pro Ser Arg Phe 180 185 190 Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Lys Ile Ser Ser Leu 195 200 205 Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys Glu Asp Thr Ser Lys Tyr 210 215 220 Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Ser Gly Gly 225 230 235 240 Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 245 250 255 Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 260 265 270 Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 275 280 285 Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr 290 295 300 Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser 305 310 315 320 Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr 325 330 335 Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile 340 345 350 Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 355 360 365 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 370 375 380 Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr 385 390 395 400 Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn 405 410 415 Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu 420 425 430 Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser 435 440 445 Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln 450 455 460 Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg 465 470 475 480 Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 485 490 <210> 521 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-53 <400> 521 Asn Ala Trp Met Asp 1 5 <210> 522 <211> 19 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-53 <400> 522 Gln Ile Thr Ala Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Ala Pro 1 5 10 15 Val Lys Gly <210> 523 <211> 4 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-53 <400> 523 Asp Gly Tyr His 1 <210> 524 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-53 <400> 524 Arg Ala Ser Glu Asp Ile Arg Asn Gly Leu Ala 1 5 10 <210> 525 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-53 <400> 525 Asn Ala Asn Ser Leu His Ser 1 5 <210> 526 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-53 <400> 526 Glu Asp Thr Ser Lys Tyr Pro Tyr Thr 1 5 <210> 527 <211> 115 <212> PRT <213> artificial <220> <223> VH de BCMA-53 <400> 527 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 20 25 30 Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Ile 35 40 45 Ala Gln Ile Thr Ala Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Ala 50 55 60 Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Lys Lys Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Thr Asp Asp Gly Tyr His Trp Gly Gln Gly Thr Leu Val Thr 100 105 110 Val Ser Ser 115 <210> 528 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-53 <400> 528 Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Lys Cys Arg Ala Ser Glu Asp Ile Arg Asn Gly 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asn Ala Asn Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Met Gln Pro 65 70 75 80 Glu Asp Glu Gly Thr Tyr Tyr Cys Glu Asp Thr Ser Lys Tyr Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 529 <211> 237 <212> PRT <213> artificial <220> <223> BCMA-53 scFv <400> 529 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 20 25 30 Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Ile 35 40 45 Ala Gln Ile Thr Ala Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Ala 50 55 60 Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Lys Lys Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Thr Asp Asp Gly Tyr His Trp Gly Gln Gly Thr Leu Val Thr 100 105 110 Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 130 135 140 Val Gly Asp Arg Val Thr Ile Lys Cys Arg Ala Ser Glu Asp Ile Arg 145 150 155 160 Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 165 170 175 Leu Ile Tyr Asn Ala Asn Ser Leu His Ser Gly Val Pro Ser Arg Phe 180 185 190 Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Met 195 200 205 Gln Pro Glu Asp Glu Gly Thr Tyr Tyr Cys Glu Asp Thr Ser Lys Tyr 210 215 220 Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 225 230 235 <210> 530 <211> 492 <212> PRT <213> artificial <220> <223> BCMA-53 HL x CD3 HL molécula biespecífica <400> 530 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 20 25 30 Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Ile 35 40 45 Ala Gln Ile Thr Ala Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Ala 50 55 60 Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Lys Lys Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Thr Asp Asp Gly Tyr His Trp Gly Gln Gly Thr Leu Val Thr 100 105 110 Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 130 135 140 Val Gly Asp Arg Val Thr Ile Lys Cys Arg Ala Ser Glu Asp Ile Arg 145 150 155 160 Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 165 170 175 Leu Ile Tyr Asn Ala Asn Ser Leu His Ser Gly Val Pro Ser Arg Phe 180 185 190 Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Met 195 200 205 Gln Pro Glu Asp Glu Gly Thr Tyr Tyr Cys Glu Asp Thr Ser Lys Tyr 210 215 220 Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Ser Gly Gly 225 230 235 240 Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 245 250 255 Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 260 265 270 Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 275 280 285 Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr 290 295 300 Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser 305 310 315 320 Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr 325 330 335 Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile 340 345 350 Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 355 360 365 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 370 375 380 Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr 385 390 395 400 Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn 405 410 415 Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu 420 425 430 Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser 435 440 445 Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln 450 455 460 Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg 465 470 475 480 Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 485 490 <210> 531 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-54 <400> 531 Asn Ala Trp Met Asp 1 5 <210> 532 <211> 19 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-54 <400> 532 Gln Ile Thr Ala Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Ala Pro 1 5 10 15 Val Lys Gly <210> 533 <211> 4 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-54 <400> 533 Asp Gly Tyr His 1 <210> 534 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-54 <400> 534 Arg Ala Ser Glu Asp Ile Arg Asn Gly Leu Ala 1 5 10 <210> 535 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-54 <400> 535 Asn Ala Asn Ser Leu His Thr 1 5 <210> 536 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-54 <400> 536 Glu Asp Thr Ser Lys Tyr Pro Tyr Thr 1 5 <210> 537 <211> 115 <212> PRT <213> artificial <220> <223> VH de BCMA-54 <400> 537 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 20 25 30 Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Ile 35 40 45 Ala Gln Ile Thr Ala Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Ala 50 55 60 Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Lys Lys Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Thr Asp Asp Gly Tyr His Trp Gly Gln Gly Thr Leu Val Thr 100 105 110 Val Ser Ser 115 <210> 538 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-54 <400> 538 Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Ala Cys Arg Ala Ser Glu Asp Ile Arg Asn Gly 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asn Ala Asn Ser Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Glu Ala Ile Tyr Tyr Cys Glu Asp Thr Ser Lys Tyr Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 539 <211> 237 <212> PRT <213> artificial <220> <223> BCMA-54 scFv <400> 539 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 20 25 30 Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Ile 35 40 45 Ala Gln Ile Thr Ala Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Ala 50 55 60 Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Lys Lys Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Thr Asp Asp Gly Tyr His Trp Gly Gln Gly Thr Leu Val Thr 100 105 110 Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 130 135 140 Val Gly Asp Arg Val Thr Ile Ala Cys Arg Ala Ser Glu Asp Ile Arg 145 150 155 160 Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 165 170 175 Leu Ile Tyr Asn Ala Asn Ser Leu His Thr Gly Val Pro Ser Arg Phe 180 185 190 Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 195 200 205 Gln Pro Glu Asp Glu Ala Ile Tyr Tyr Cys Glu Asp Thr Ser Lys Tyr 210 215 220 Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 225 230 235 <210> 540 <211> 492 <212> PRT <213> artificial <220> <223> BCMA-54 HL x CD3 HL molécula biespecífica <400> 540 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 20 25 30 Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Ile 35 40 45 Ala Gln Ile Thr Ala Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Ala 50 55 60 Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Lys Lys Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Thr Asp Asp Gly Tyr His Trp Gly Gln Gly Thr Leu Val Thr 100 105 110 Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 130 135 140 Val Gly Asp Arg Val Thr Ile Ala Cys Arg Ala Ser Glu Asp Ile Arg 145 150 155 160 Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 165 170 175 Leu Ile Tyr Asn Ala Asn Ser Leu His Thr Gly Val Pro Ser Arg Phe 180 185 190 Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 195 200 205 Gln Pro Glu Asp Glu Ala Ile Tyr Tyr Cys Glu Asp Thr Ser Lys Tyr 210 215 220 Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Ser Gly Gly 225 230 235 240 Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 245 250 255 Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 260 265 270 Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 275 280 285 Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr 290 295 300 Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser 305 310 315 320 Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr 325 330 335 Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile 340 345 350 Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 355 360 365 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 370 375 380 Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr 385 390 395 400 Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn 405 410 415 Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu 420 425 430 Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser 435 440 445 Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln 450 455 460 Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg 465 470 475 480 Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 485 490 <210> 541 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-55 <400> 541 Asn Ala Trp Met Asp 1 5 <210> 542 <211> 19 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-55 <400> 542 Gln Ile Thr Ala Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Ala Pro 1 5 10 15 Val Lys Gly <210> 543 <211> 4 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-55 <400> 543 Asp Gly Tyr His 1 <210> 544 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-55 <400> 544 Arg Ala Ser Glu Asp Ile Arg Asn Gly Leu Ala 1 5 10 <210> 545 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-55 <400> 545 Asn Ala Asn Ser Leu His Thr 1 5 <210> 546 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-55 <400> 546 Glu Glu Thr Leu Lys Tyr Pro Tyr Thr 1 5 <210> 547 <211> 115 <212> PRT <213> artificial <220> <223> VH de BCMA-55 <400> 547 Glu Val Gln Leu Val Glu Ser Gly Gly Ser Leu Val Lys Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 20 25 30 Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 35 40 45 Ala Gln Ile Thr Ala Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Ala 50 55 60 Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Lys Glu Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Thr Asp Asp Gly Tyr His Trp Gly Gln Gly Thr Leu Val Thr 100 105 110 Val Ser Ser 115 <210> 548 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-55 <400> 548 Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Ala Cys Arg Ala Ser Glu Asp Ile Arg Asn Gly 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asn Ala Asn Ser Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 65 70 75 80 Glu Asp Glu Ala Thr Tyr Tyr Cys Glu Glu Thr Leu Lys Tyr Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 549 <211> 237 <212> PRT <213> artificial <220> <223> BCMA-55 scFv <400> 549 Glu Val Gln Leu Val Glu Ser Gly Gly Ser Leu Val Lys Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 20 25 30 Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 35 40 45 Ala Gln Ile Thr Ala Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Ala 50 55 60 Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Lys Glu Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Thr Asp Asp Gly Tyr His Trp Gly Gln Gly Thr Leu Val Thr 100 105 110 Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 130 135 140 Val Gly Asp Arg Val Thr Ile Ala Cys Arg Ala Ser Glu Asp Ile Arg 145 150 155 160 Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 165 170 175 Leu Ile Tyr Asn Ala Asn Ser Leu His Thr Gly Val Pro Ser Arg Phe 180 185 190 Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu 195 200 205 Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys Glu Glu Thr Leu Lys Tyr 210 215 220 Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 225 230 235 <210> 550 <211> 492 <212> PRT <213> artificial <220> <223> BCMA-55 HL x CD3 HL molécula biespecífica <400> 550 Glu Val Gln Leu Val Glu Ser Gly Gly Ser Leu Val Lys Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 20 25 30 Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 35 40 45 Ala Gln Ile Thr Ala Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Ala 50 55 60 Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Lys Glu Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Thr Asp Asp Gly Tyr His Trp Gly Gln Gly Thr Leu Val Thr 100 105 110 Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 130 135 140 Val Gly Asp Arg Val Thr Ile Ala Cys Arg Ala Ser Glu Asp Ile Arg 145 150 155 160 Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 165 170 175 Leu Ile Tyr Asn Ala Asn Ser Leu His Thr Gly Val Pro Ser Arg Phe 180 185 190 Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu 195 200 205 Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys Glu Glu Thr Leu Lys Tyr 210 215 220 Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Ser Gly Gly 225 230 235 240 Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 245 250 255 Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 260 265 270 Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 275 280 285 Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr 290 295 300 Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser 305 310 315 320 Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr 325 330 335 Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile 340 345 350 Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 355 360 365 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 370 375 380 Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr 385 390 395 400 Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn 405 410 415 Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu 420 425 430 Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser 435 440 445 Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln 450 455 460 Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg 465 470 475 480 Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 485 490 <210> 551 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-56 <400> 551 Asn Ala Trp Met Asp 1 5 <210> 552 <211> 19 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-56 <400> 552 Gln Ile Thr Ala Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Glu Pro 1 5 10 15 Val Lys Gly <210> 553 <211> 4 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-56 <400> 553 Asp Gly Tyr His 1 <210> 554 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-56 <400> 554 Arg Ala Ser Glu Asp Ile Arg Asn Gly Leu Ala 1 5 10 <210> 555 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-56 <400> 555 Asn Ala Asn Ser Leu His Thr 1 5 <210> 556 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-56 <400> 556 Glu Glu Thr Leu Lys Tyr Pro Tyr Thr 1 5 <210> 557 <211> 115 <212> PRT <213> artificial <220> <223> VH de BCMA-56 <400> 557 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 20 25 30 Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 35 40 45 Ala Gln Ile Thr Ala Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Glu 50 55 60 Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Thr Asp Asp Gly Tyr His Trp Gly Gln Gly Thr Leu Val Thr 100 105 110 Val Ser Ser 115 <210> 558 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-56 <400> 558 Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Glu Thr Val Thr Ile Ala Cys Arg Ala Ser Glu Asp Ile Arg Asn Gly 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asn Ala Asn Ser Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Lys Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Glu Ala Thr Tyr Tyr Cys Glu Glu Thr Leu Lys Tyr Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 559 <211> 237 <212> PRT <213> artificial <220> <223> BCMA-56 scFv <400> 559 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 20 25 30 Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 35 40 45 Ala Gln Ile Thr Ala Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Glu 50 55 60 Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Thr Asp Asp Gly Tyr His Trp Gly Gln Gly Thr Leu Val Thr 100 105 110 Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 130 135 140 Val Gly Glu Thr Val Thr Ile Ala Cys Arg Ala Ser Glu Asp Ile Arg 145 150 155 160 Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 165 170 175 Leu Ile Tyr Asn Ala Asn Ser Leu His Thr Gly Val Pro Ser Arg Phe 180 185 190 Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Lys Ile Ser Ser Leu 195 200 205 Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys Glu Glu Thr Leu Lys Tyr 210 215 220 Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 225 230 235 <210> 560 <211> 492 <212> PRT <213> artificial <220> <223> BCMA-56 HL x CD3 HL molécula biespecífica <400> 560 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 20 25 30 Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 35 40 45 Ala Gln Ile Thr Ala Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Glu 50 55 60 Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Thr Asp Asp Gly Tyr His Trp Gly Gln Gly Thr Leu Val Thr 100 105 110 Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 130 135 140 Val Gly Glu Thr Val Thr Ile Ala Cys Arg Ala Ser Glu Asp Ile Arg 145 150 155 160 Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 165 170 175 Leu Ile Tyr Asn Ala Asn Ser Leu His Thr Gly Val Pro Ser Arg Phe 180 185 190 Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Lys Ile Ser Ser Leu 195 200 205 Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys Glu Glu Thr Leu Lys Tyr 210 215 220 Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Ser Gly Gly 225 230 235 240 Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 245 250 255 Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 260 265 270 Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 275 280 285 Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr 290 295 300 Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser 305 310 315 320 Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr 325 330 335 Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile 340 345 350 Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 355 360 365 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 370 375 380 Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr 385 390 395 400 Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn 405 410 415 Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu 420 425 430 Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser 435 440 445 Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln 450 455 460 Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg 465 470 475 480 Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 485 490 <210> 561 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-57 <400> 561 Asn Ala Trp Met Asp 1 5 <210> 562 <211> 19 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-57 <400> 562 Gln Ile Thr Ala Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Ala Pro 1 5 10 15 Val Lys Gly <210> 563 <211> 4 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-57 <400> 563 Asp Gly Tyr His 1 <210> 564 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-57 <400> 564 Arg Ala Ser Glu Asp Ile Arg Asn Gly Leu Ala 1 5 10 <210> 565 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-57 <400> 565 Asn Ala Asn Ser Leu His Thr 1 5 <210> 566 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-57 <400> 566 Glu Glu Thr Leu Lys Tyr Pro Tyr Thr 1 5 <210> 567 <211> 115 <212> PRT <213> artificial <220> <223> VH de BCMA-57 <400> 567 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 20 25 30 Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Ile 35 40 45 Ala Gln Ile Thr Ala Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Ala 50 55 60 Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Lys Lys Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Thr Asp Asp Gly Tyr His Trp Gly Gln Gly Thr Leu Val Thr 100 105 110 Val Ser Ser 115 <210> 568 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-57 <400> 568 Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Ala Cys Arg Ala Ser Glu Asp Ile Arg Asn Gly 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asn Ala Asn Ser Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Glu Ala Ile Tyr Tyr Cys Glu Glu Thr Leu Lys Tyr Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 569 <211> 237 <212> PRT <213> artificial <220> <223> BCMA-57 scFv <400> 569 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 20 25 30 Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Ile 35 40 45 Ala Gln Ile Thr Ala Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Ala 50 55 60 Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Lys Lys Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Thr Asp Asp Gly Tyr His Trp Gly Gln Gly Thr Leu Val Thr 100 105 110 Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 130 135 140 Val Gly Asp Arg Val Thr Ile Ala Cys Arg Ala Ser Glu Asp Ile Arg 145 150 155 160 Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 165 170 175 Leu Ile Tyr Asn Ala Asn Ser Leu His Thr Gly Val Pro Ser Arg Phe 180 185 190 Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 195 200 205 Gln Pro Glu Asp Glu Ala Ile Tyr Tyr Cys Glu Glu Thr Leu Lys Tyr 210 215 220 Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 225 230 235 <210> 570 <211> 492 <212> PRT <213> artificial <220> <223> BCMA-57 HL x CD3 HL molécula biespecífica <400> 570 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 20 25 30 Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Ile 35 40 45 Ala Gln Ile Thr Ala Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Ala 50 55 60 Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Lys Lys Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Thr Asp Asp Gly Tyr His Trp Gly Gln Gly Thr Leu Val Thr 100 105 110 Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 130 135 140 Val Gly Asp Arg Val Thr Ile Ala Cys Arg Ala Ser Glu Asp Ile Arg 145 150 155 160 Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 165 170 175 Leu Ile Tyr Asn Ala Asn Ser Leu His Thr Gly Val Pro Ser Arg Phe 180 185 190 Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 195 200 205 Gln Pro Glu Asp Glu Ala Ile Tyr Tyr Cys Glu Glu Thr Leu Lys Tyr 210 215 220 Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Ser Gly Gly 225 230 235 240 Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 245 250 255 Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 260 265 270 Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 275 280 285 Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr 290 295 300 Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser 305 310 315 320 Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr 325 330 335 Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile 340 345 350 Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 355 360 365 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 370 375 380 Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr 385 390 395 400 Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn 405 410 415 Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu 420 425 430 Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser 435 440 445 Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln 450 455 460 Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg 465 470 475 480 Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 485 490 <210> 571 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-58 <400> 571 Asn Ala Trp Met Asp 1 5 <210> 572 <211> 19 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-58 <400> 572 Gln Ile Thr Ala Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Ala Pro 1 5 10 15 Val Lys Gly <210> 573 <211> 4 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-58 <400> 573 Asp Gly Tyr His 1 <210> 574 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-58 <400> 574 Arg Ala Ser Glu Asp Ile Arg Asn Gly Leu Ala 1 5 10 <210> 575 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-58 <400> 575 Asn Ala Asn Ser Leu His Ser 1 5 <210> 576 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-58 <400> 576 Glu Glu Thr Leu Lys Tyr Pro Tyr Thr 1 5 <210> 577 <211> 115 <212> PRT <213> artificial <220> <223> VH de BCMA-58 <400> 577 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 20 25 30 Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Ile 35 40 45 Ala Gln Ile Thr Ala Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Ala 50 55 60 Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Lys Lys Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Thr Asp Asp Gly Tyr His Trp Gly Gln Gly Thr Leu Val Thr 100 105 110 Val Ser Ser 115 <210> 578 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-58 <400> 578 Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Lys Cys Arg Ala Ser Glu Asp Ile Arg Asn Gly 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asn Ala Asn Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Met Gln Pro 65 70 75 80 Glu Asp Glu Gly Thr Tyr Tyr Cys Glu Glu Thr Leu Lys Tyr Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 579 <211> 237 <212> PRT <213> artificial <220> <223> BCMA-58 scFv <400> 579 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 20 25 30 Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Ile 35 40 45 Ala Gln Ile Thr Ala Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Ala 50 55 60 Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Lys Lys Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Thr Asp Asp Gly Tyr His Trp Gly Gln Gly Thr Leu Val Thr 100 105 110 Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 130 135 140 Val Gly Asp Arg Val Thr Ile Lys Cys Arg Ala Ser Glu Asp Ile Arg 145 150 155 160 Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 165 170 175 Leu Ile Tyr Asn Ala Asn Ser Leu His Ser Gly Val Pro Ser Arg Phe 180 185 190 Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Met 195 200 205 Gln Pro Glu Asp Glu Gly Thr Tyr Tyr Cys Glu Glu Thr Leu Lys Tyr 210 215 220 Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 225 230 235 <210> 580 <211> 492 <212> PRT <213> artificial <220> <223> BCMA-58 HL x CD3 HL molécula biespecífica <400> 580 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 20 25 30 Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Ile 35 40 45 Ala Gln Ile Thr Ala Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Ala 50 55 60 Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Lys Lys Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Thr Asp Asp Gly Tyr His Trp Gly Gln Gly Thr Leu Val Thr 100 105 110 Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 130 135 140 Val Gly Asp Arg Val Thr Ile Lys Cys Arg Ala Ser Glu Asp Ile Arg 145 150 155 160 Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 165 170 175 Leu Ile Tyr Asn Ala Asn Ser Leu His Ser Gly Val Pro Ser Arg Phe 180 185 190 Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Met 195 200 205 Gln Pro Glu Asp Glu Gly Thr Tyr Tyr Cys Glu Glu Thr Leu Lys Tyr 210 215 220 Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Ser Gly Gly 225 230 235 240 Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 245 250 255 Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 260 265 270 Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 275 280 285 Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr 290 295 300 Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser 305 310 315 320 Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr 325 330 335 Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile 340 345 350 Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 355 360 365 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 370 375 380 Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr 385 390 395 400 Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn 405 410 415 Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu 420 425 430 Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser 435 440 445 Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln 450 455 460 Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg 465 470 475 480 Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 485 490 <210> 581 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-59 <400> 581 Asn Tyr Asp Met Ala 1 5 <210> 582 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-59 <400> 582 Ser Ile Ile Thr Ser Gly Gly Asp Asn Tyr Tyr Arg Asp Ser Val Lys 1 5 10 15 Gly <210> 583 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-59 <400> 583 His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr 1 5 10 <210> 584 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-59 <400> 584 Lys Ala Ser Gln Ser Val Gly Ile Asn Val Asp 1 5 10 <210> 585 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-59 <400> 585 Gly Ala Ser Asn Arg His Thr 1 5 <210> 586 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-59 <400> 586 Leu Gln Tyr Gly Ser Ile Pro Phe Thr 1 5 <210> 587 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-59 <400> 587 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ser Ile Ile Thr Ser Gly Gly Asp Asn Tyr Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 588 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-59 <400> 588 Glu Ile Val Met Thr Gln Ser Pro Ala Ser Met Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Gly Ile Asn 20 25 30 Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Asn Arg His Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Tyr Gly Ser Ile Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 <210> 589 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-59 scFv <400> 589 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ser Ile Ile Thr Ser Gly Gly Asp Asn Tyr Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 130 135 140 Ala Ser Met Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Lys 145 150 155 160 Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr 180 185 190 Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 210 215 220 Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 225 230 235 240 Asp Ile Lys <210> 590 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-59 HL x CD3 HL molécula biespecífica <400> 590 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ser Ile Ile Thr Ser Gly Gly Asp Asn Tyr Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 130 135 140 Ala Ser Met Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Lys 145 150 155 160 Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr 180 185 190 Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 210 215 220 Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 225 230 235 240 Asp Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 591 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-60 <400> 591 Asn Tyr Asp Met Ala 1 5 <210> 592 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-60 <400> 592 Ser Ile Ile Thr Ser Gly Gly Asp Asn Tyr Tyr Arg Asp Ser Val Lys 1 5 10 15 Gly <210> 593 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-60 <400> 593 His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr 1 5 10 <210> 594 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-60 <400> 594 Lys Ala Ser Gln Ser Val Gly Ile Asn Val Asp 1 5 10 <210> 595 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-60 <400> 595 Gly Ala Ser Asn Arg His Thr 1 5 <210> 596 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-60 <400> 596 Leu Gln Tyr Gly Ser Ile Pro Phe Thr 1 5 <210> 597 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-60 <400> 597 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ser Ile Ile Thr Ser Gly Gly Asp Asn Tyr Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 598 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-60 <400> 598 Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Val Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Gly Ile Asn 20 25 30 Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Asn Arg His Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Arg Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Tyr Gly Ser Ile Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 <210> 599 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-60 scFv <400> 599 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ser Ile Ile Thr Ser Gly Gly Asp Asn Tyr Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 130 135 140 Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Val Thr Leu Ser Cys Lys 145 150 155 160 Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr 180 185 190 Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Arg Glu Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 210 215 220 Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 225 230 235 240 Asp Ile Lys <210> 600 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-60 HL x CD3 HL molécula biespecífica <400> 600 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ser Ile Ile Thr Ser Gly Gly Asp Asn Tyr Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 130 135 140 Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Val Thr Leu Ser Cys Lys 145 150 155 160 Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr 180 185 190 Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Arg Glu Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 210 215 220 Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 225 230 235 240 Asp Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 601 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-61 <400> 601 Asn Tyr Asp Met Ala 1 5 <210> 602 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-61 <400> 602 Ser Ile Ile Thr Ser Gly Gly Asp Asn Tyr Tyr Arg Asp Ser Val Lys 1 5 10 15 Gly <210> 603 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-61 <400> 603 His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr 1 5 10 <210> 604 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-61 <400> 604 Lys Ala Ser Gln Ser Val Gly Ile Asn Val Asp 1 5 10 <210> 605 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-61 <400> 605 Gly Ala Ser Asn Arg His Thr 1 5 <210> 606 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-61 <400> 606 Leu Gln Tyr Gly Ser Ile Pro Phe Thr 1 5 <210> 607 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-61 <400> 607 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ser Ile Ile Thr Ser Gly Gly Asp Asn Tyr Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 608 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-61 <400> 608 Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Val Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Gly Ile Asn 20 25 30 Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Asn Arg His Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Tyr Gly Ser Ile Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 <210> 609 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-61 scFv <400> 609 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ser Ile Ile Thr Ser Gly Gly Asp Asn Tyr Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 130 135 140 Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Val Thr Leu Ser Cys Lys 145 150 155 160 Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr 180 185 190 Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 210 215 220 Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 225 230 235 240 Asp Ile Lys <210> 610 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-61 HL x CD3 HL molécula biespecífica <400> 610 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ser Ile Ile Thr Ser Gly Gly Asp Asn Tyr Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 130 135 140 Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Val Thr Leu Ser Cys Lys 145 150 155 160 Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr 180 185 190 Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 210 215 220 Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 225 230 235 240 Asp Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 611 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-62 <400> 611 Asn Tyr Asp Met Ala 1 5 <210> 612 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-62 <400> 612 Ser Ile Ile Thr Ser Gly Gly Asp Asn Tyr Tyr Arg Asp Ser Val Lys 1 5 10 15 Gly <210> 613 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-62 <400> 613 His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr 1 5 10 <210> 614 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-62 <400> 614 Lys Ala Ser Gln Ser Val Gly Ile Asn Val Asp 1 5 10 <210> 615 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-62 <400> 615 Gly Ala Ser Asn Arg His Thr 1 5 <210> 616 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-62 <400> 616 Leu Gln Tyr Gly Ser Ile Pro Phe Thr 1 5 <210> 617 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-62 <400> 617 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ser Ile Ile Thr Ser Gly Gly Asp Asn Tyr Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 618 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-62 <400> 618 Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Gly Ile Asn 20 25 30 Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Asn Arg His Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Tyr Gly Ser Ile Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 <210> 619 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-62 scFv <400> 619 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ser Ile Ile Thr Ser Gly Gly Asp Asn Tyr Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 130 135 140 Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Lys 145 150 155 160 Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr 180 185 190 Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Phe Ala Val Tyr Tyr Cys 210 215 220 Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 225 230 235 240 Asp Ile Lys <210> 620 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-62 HL x CD3 HL molécula biespecífica <400> 620 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ser Ile Ile Thr Ser Gly Gly Asp Asn Tyr Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 130 135 140 Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Lys 145 150 155 160 Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg His Thr 180 185 190 Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Phe Ala Val Tyr Tyr Cys 210 215 220 Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 225 230 235 240 Asp Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 621 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-63 <400> 621 Asn Tyr Asp Met Ala 1 5 <210> 622 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-63 <400> 622 Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val Lys 1 5 10 15 Gly <210> 623 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-63 <400> 623 Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr 1 5 10 <210> 624 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-63 <400> 624 Arg Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala 1 5 10 <210> 625 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-63 <400> 625 Gly Ala Ser Ser Leu Gln Asp 1 5 <210> 626 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-63 <400> 626 Gln Gln Ser Tyr Lys Tyr Pro Leu Thr 1 5 <210> 627 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-63 <400> 627 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 628 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-63 <400> 628 Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asp Ile Tyr Asn Gly 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Ser Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Glu Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Lys Tyr Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 629 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-63 scFv <400> 629 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Thr Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Asp 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Ser Tyr Lys Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 225 230 235 240 Glu Ile Lys <210> 630 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-63 HL x CD3 HL molécula biespecífica <400> 630 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Thr Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Asp 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Ser Tyr Lys Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 631 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-64 <400> 631 Asn Tyr Asp Met Ala 1 5 <210> 632 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-64 <400> 632 Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val Lys 1 5 10 15 Gly <210> 633 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-64 <400> 633 Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr 1 5 10 <210> 634 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-64 <400> 634 Arg Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala 1 5 10 <210> 635 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-64 <400> 635 Gly Ala Ser Ser Leu Gln Asp 1 5 <210> 636 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-64 <400> 636 Gln Gln Ser Tyr Lys Tyr Pro Leu Thr 1 5 <210> 637 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-64 <400> 637 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 638 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-64 <400> 638 Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asp Ile Tyr Asn Gly 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Ser Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Met Gln Pro 65 70 75 80 Glu Asp Glu Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Lys Tyr Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 639 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-64 scFv <400> 639 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Asp 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 195 200 205 Leu Thr Ile Ser Ser Met Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Ser Tyr Lys Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 225 230 235 240 Glu Ile Lys <210> 640 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-64 HL x CD3 HL molécula biespecífica <400> 640 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Asp 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 195 200 205 Leu Thr Ile Ser Ser Met Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Ser Tyr Lys Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 641 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-65 <400> 641 Asn Tyr Asp Met Ala 1 5 <210> 642 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-65 <400> 642 Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val Lys 1 5 10 15 Gly <210> 643 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-65 <400> 643 Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr 1 5 10 <210> 644 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-65 <400> 644 Arg Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala 1 5 10 <210> 645 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-65 <400> 645 Gly Ala Ser Ser Leu Gln Asp 1 5 <210> 646 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-65 <400> 646 Gln Gln Ser Tyr Lys Tyr Pro Leu Thr 1 5 <210> 647 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-65 <400> 647 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 648 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-65 <400> 648 Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asp Ile Tyr Asn Gly 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Ser Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr His Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Glu Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Lys Tyr Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 649 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-65 scFv <400> 649 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Asp 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr His Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Ser Tyr Lys Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 225 230 235 240 Glu Ile Lys <210> 650 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-65 HL x CD3 HL molécula biespecífica <400> 650 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Asp 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr His Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Ser Tyr Lys Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 651 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-66 <400> 651 Asn Tyr Asp Met Ala 1 5 <210> 652 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-66 <400> 652 Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val Lys 1 5 10 15 Gly <210> 653 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-66 <400> 653 Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr 1 5 10 <210> 654 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-66 <400> 654 Arg Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala 1 5 10 <210> 655 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-66 <400> 655 Gly Ala Ser Ser Leu Gln Asp 1 5 <210> 656 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-66 <400> 656 Ala Gly Pro His Lys Tyr Pro Leu Thr 1 5 <210> 657 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-66 <400> 657 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 658 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-66 <400> 658 Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asp Ile Tyr Asn Gly 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Ser Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Glu Ala Thr Tyr Tyr Cys Ala Gly Pro His Lys Tyr Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 659 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-66 scFv <400> 659 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Thr Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Asp 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys 210 215 220 Ala Gly Pro His Lys Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 225 230 235 240 Glu Ile Lys <210> 660 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-66 HL x CD3 HL molécula biespecífica <400> 660 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Thr Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Asp 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys 210 215 220 Ala Gly Pro His Lys Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 661 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-67 <400> 661 Asn Tyr Asp Met Ala 1 5 <210> 662 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-67 <400> 662 Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val Lys 1 5 10 15 Gly <210> 663 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-67 <400> 663 Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr 1 5 10 <210> 664 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-67 <400> 664 Arg Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala 1 5 10 <210> 665 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-67 <400> 665 Gly Ala Ser Ser Leu Gln Asp 1 5 <210> 666 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-67 <400> 666 Ala Gly Pro His Lys Tyr Pro Leu Thr 1 5 <210> 667 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-67 <400> 667 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 668 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-67 <400> 668 Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asp Ile Tyr Asn Gly 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Ser Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr His Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Glu Ala Thr Tyr Tyr Cys Ala Gly Pro His Lys Tyr Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 669 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-67 scFv <400> 669 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Asp 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr His Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys 210 215 220 Ala Gly Pro His Lys Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 225 230 235 240 Glu Ile Lys <210> 670 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-67 HL x CD3 HL molécula biespecífica <400> 670 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Asp 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr His Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys 210 215 220 Ala Gly Pro His Lys Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 671 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-68 <400> 671 Asn Tyr Asp Met Ala 1 5 <210> 672 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-68 <400> 672 Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val Lys 1 5 10 15 Gly <210> 673 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-68 <400> 673 Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr 1 5 10 <210> 674 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-68 <400> 674 Arg Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala 1 5 10 <210> 675 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-68 <400> 675 Gly Ala Ser Ser Leu Gln Asp 1 5 <210> 676 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-68 <400> 676 Gln Gln Ser Arg Asn Tyr Gln Gln Thr 1 5 <210> 677 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-68 <400> 677 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 678 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-68 <400> 678 Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asp Ile Tyr Asn Gly 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Ser Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Glu Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Asn Tyr Gln Gln 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 679 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-68 scFv <400> 679 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Thr Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Asp 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Ser Arg Asn Tyr Gln Gln Thr Phe Gly Gly Gly Thr Lys Val 225 230 235 240 Glu Ile Lys <210> 680 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-68 HL x CD3 HL molécula biespecífica <400> 680 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Thr Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Asp 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Ser Arg Asn Tyr Gln Gln Thr Phe Gly Gly Gly Thr Lys Val 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 681 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-69 <400> 681 Asn Tyr Asp Met Ala 1 5 <210> 682 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-69 <400> 682 Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val Lys 1 5 10 15 Gly <210> 683 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-69 <400> 683 Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr 1 5 10 <210> 684 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-69 <400> 684 Arg Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala 1 5 10 <210> 685 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-69 <400> 685 Gly Ala Ser Ser Leu Gln Asp 1 5 <210> 686 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-69 <400> 686 Gln Gln Ser Arg Asn Tyr Gln Gln Thr 1 5 <210> 687 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-69 <400> 687 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 688 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-69 <400> 688 Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asp Ile Tyr Asn Gly 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Ser Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr His Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Glu Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Asn Tyr Gln Gln 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 689 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-69 scFv <400> 689 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Asp 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr His Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Ser Arg Asn Tyr Gln Gln Thr Phe Gly Gly Gly Thr Lys Val 225 230 235 240 Glu Ile Lys <210> 690 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-69 HL x CD3 HL molécula biespecífica <400> 690 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Asp 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr His Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Ser Arg Asn Tyr Gln Gln Thr Phe Gly Gly Gly Thr Lys Val 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 691 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-70 <400> 691 Asn Tyr Asp Met Ala 1 5 <210> 692 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-70 <400> 692 Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val Lys 1 5 10 15 Gly <210> 693 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-70 <400> 693 Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr 1 5 10 <210> 694 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-70 <400> 694 Arg Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala 1 5 10 <210> 695 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-70 <400> 695 Gly Ala Ser Ser Leu Gln Asp 1 5 <210> 696 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-70 <400> 696 Gln Gln Ser Arg Asn Tyr Gln Gln Thr 1 5 <210> 697 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-70 <400> 697 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 698 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-70 <400> 698 Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asp Ile Tyr Asn Gly 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Ser Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Glu Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Asn Tyr Gln Gln 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 699 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-70 de scFv <400> 699 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Asp 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Ser Arg Asn Tyr Gln Gln Thr Phe Gly Gly Gly Thr Lys Val 225 230 235 240 Glu Ile Lys <210> 700 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-70 HL x CD3 HL molécula biespecífica <400> 700 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Asp 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Ser Arg Asn Tyr Gln Gln Thr Phe Gly Gly Gly Thr Lys Val 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 701 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-71 <400> 701 Asn Tyr Asp Met Ala 1 5 <210> 702 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-71 <400> 702 Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val Lys 1 5 10 15 Gly <210> 703 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-71 <400> 703 Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr 1 5 10 <210> 704 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-71 <400> 704 Arg Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala 1 5 10 <210> 705 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-71 <400> 705 Gly Ala Ser Ser Leu Gln Asp 1 5 <210> 706 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-71 <400> 706 Ala Gly Pro His Lys Tyr Pro Leu Thr 1 5 <210> 707 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-71 <400> 707 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 708 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-71 <400> 708 Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asp Ile Tyr Asn Gly 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Ser Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Glu Ala Thr Tyr Tyr Cys Ala Gly Pro His Lys Tyr Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 709 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-71 scFv <400> 709 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Asp 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys 210 215 220 Ala Gly Pro His Lys Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 225 230 235 240 Glu Ile Lys <210> 710 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-71 HL x CD3 HL molécula biespecífica <400> 710 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Asp 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys 210 215 220 Ala Gly Pro His Lys Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 711 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-72 <400> 711 Asn Tyr Asp Met Ala 1 5 <210> 712 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-72 <400> 712 Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val Lys 1 5 10 15 Gly <210> 713 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-72 <400> 713 Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr 1 5 10 <210> 714 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-72 <400> 714 Arg Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala 1 5 10 <210> 715 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-72 <400> 715 Gly Ala Ser Ser Leu Gln Asp 1 5 <210> 716 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-72 <400> 716 Ala Gly Pro His Lys Tyr Pro Leu Thr 1 5 <210> 717 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-72 <400> 717 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 718 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-72 <400> 718 Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asp Ile Tyr Asn Gly 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Ser Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Met Gln Pro 65 70 75 80 Glu Asp Glu Ala Thr Tyr Tyr Cys Ala Gly Pro His Lys Tyr Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 719 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-72 scFv <400> 719 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Asp 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 195 200 205 Leu Thr Ile Ser Ser Met Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys 210 215 220 Ala Gly Pro His Lys Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 225 230 235 240 Glu Ile Lys <210> 720 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-72 HL x CD3 HL molécula biespecífica <400> 720 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Asp 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 195 200 205 Leu Thr Ile Ser Ser Met Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys 210 215 220 Ala Gly Pro His Lys Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 721 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-73 <400> 721 Asn Tyr Asp Met Ala 1 5 <210> 722 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-73 <400> 722 Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val Lys 1 5 10 15 Gly <210> 723 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-73 <400> 723 Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr 1 5 10 <210> 724 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-73 <400> 724 Arg Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala 1 5 10 <210> 725 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-73 <400> 725 Gly Ala Ser Ser Leu Gln Asp 1 5 <210> 726 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-73 <400> 726 Gln Gln Ser Arg Asn Tyr Gln Gln Thr 1 5 <210> 727 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-73 <400> 727 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 728 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-73 <400> 728 Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asp Ile Tyr Asn Gly 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Ser Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Met Gln Pro 65 70 75 80 Glu Asp Glu Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Asn Tyr Gln Gln 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 729 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-73 scFv <400> 729 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Asp 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 195 200 205 Leu Thr Ile Ser Ser Met Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Ser Arg Asn Tyr Gln Gln Thr Phe Gly Gly Gly Thr Lys Val 225 230 235 240 Glu Ile Lys <210> 730 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-73 HL x CD3 HL molécula biespecífica <400> 730 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Asp 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 195 200 205 Leu Thr Ile Ser Ser Met Gln Pro Glu Asp Glu Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Ser Arg Asn Tyr Gln Gln Thr Phe Gly Gly Gly Thr Lys Val 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 731 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-74 <400> 731 Asn Phe Asp Met Ala 1 5 <210> 732 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-74 <400> 732 Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 733 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-74 <400> 733 His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr 1 5 10 <210> 734 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-74 <400> 734 Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 735 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de VL CDR2 <400> 735 Tyr Thr Ser Asn Leu Gln Ser 1 5 <210> 736 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-74 <400> 736 Met Gly Gln Thr Ile Ser Ser Tyr Thr 1 5 <210> 737 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-74 <400> 737 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 738 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-74 <400> 738 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 35 40 45 Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Met Gly Gln Thr Ile Ser Ser Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 739 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-74 scFv <400> 739 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 210 215 220 Met Gly Gln Thr Ile Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu 225 230 235 240 Glu Ile Lys <210> 740 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-74 HL x CD3 HL molécula biespecífica <400> 740 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 210 215 220 Met Gly Gln Thr Ile Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 741 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-75 <400> 741 Asn Phe Asp Met Ala 1 5 <210> 742 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-75 <400> 742 Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 743 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-75 <400> 743 His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr 1 5 10 <210> 744 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-75 <400> 744 Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 745 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-75 <400> 745 Tyr Thr Ser Asn Leu Gln Ser 1 5 <210> 746 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-75 <400> 746 Met Gly Gln Thr Ile Ser Ser Tyr Thr 1 5 <210> 747 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-75 <400> 747 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 748 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-75 <400> 748 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 35 40 45 Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Met Gly Gln Thr Ile Ser Ser Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 749 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-75 scFv <400> 749 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 210 215 220 Met Gly Gln Thr Ile Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu 225 230 235 240 Glu Ile Lys <210> 750 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-75 HL x CD3 HL molécula biespecífica <400> 750 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 210 215 220 Met Gly Gln Thr Ile Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 751 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-76 <400> 751 Asn Phe Asp Met Ala 1 5 <210> 752 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-76 <400> 752 Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 753 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-76 <400> 753 His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr 1 5 10 <210> 754 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-76 <400> 754 Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 755 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-76 <400> 755 Tyr Thr Ser Asn Leu Gln Ser 1 5 <210> 756 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-76 <400> 756 Met Gly Gln Thr Ile Ser Ser Tyr Thr 1 5 <210> 757 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-76 <400> 757 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 758 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-76 <400> 758 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 35 40 45 Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Met Gly Gln Thr Ile Ser Ser Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 759 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-76 scFv <400> 759 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Ser Cys Arg 145 150 155 160 Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 210 215 220 Met Gly Gln Thr Ile Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu 225 230 235 240 Glu Ile Lys <210> 760 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-76 HL x CD3 HL molécula biespecífica <400> 760 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Ser Cys Arg 145 150 155 160 Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 210 215 220 Met Gly Gln Thr Ile Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 761 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-77 <400> 761 Asn Phe Asp Met Ala 1 5 <210> 762 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de VH CDR2 <400> 762 Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 763 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-77 <400> 763 His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr 1 5 10 <210> 764 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-77 <400> 764 Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 765 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-77 <400> 765 Tyr Thr Ser Asn Leu Gln Ser 1 5 <210> 766 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-77 <400> 766 Met Gly Gln Thr Ile Ser Ser Tyr Thr 1 5 <210> 767 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-77 <400> 767 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Ala Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 768 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-77 <400> 768 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 35 40 45 Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Met Gly Gln Thr Ile Ser Ser Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 769 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-77 scFv <400> 769 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Ala Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 210 215 220 Met Gly Gln Thr Ile Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu 225 230 235 240 Glu Ile Lys <210> 770 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-77 HL x CD3 HL molécula biespecífica <400> 770 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Ala Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 210 215 220 Met Gly Gln Thr Ile Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 771 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-78 <400> 771 Asn Phe Asp Met Ala 1 5 <210> 772 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-78 <400> 772 Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 773 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-78 <400> 773 His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr 1 5 10 <210> 774 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-78 <400> 774 Arg Ala Ser Gln Gly Ile Ser Asn His Leu Asn 1 5 10 <210> 775 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-78 <400> 775 Tyr Thr Ser Asn Leu Gln Ser 1 5 <210> 776 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-78 <400> 776 Gln Gln Tyr Phe Asp Arg Pro Tyr Thr 1 5 <210> 777 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-78 <400> 777 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 778 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-78 <400> 778 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Gly Ile Ser Asn His 20 25 30 Leu Asn Trp Phe Gln Gln Lys Pro Gly Arg Ala Pro Lys Pro Leu Ile 35 40 45 Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Phe Asp Arg Pro Tyr 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 779 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-78 scFv <400> 779 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Ser Cys Arg 145 150 155 160 Ala Ser Gln Gly Ile Ser Asn His Leu Asn Trp Phe Gln Gln Lys Pro 165 170 175 Gly Arg Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Tyr Phe Asp Arg Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val 225 230 235 240 Glu Ile Lys <210> 780 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-78 HL x CD3 HL molécula biespecífica <400> 780 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Ser Cys Arg 145 150 155 160 Ala Ser Gln Gly Ile Ser Asn His Leu Asn Trp Phe Gln Gln Lys Pro 165 170 175 Gly Arg Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Tyr Phe Asp Arg Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 781 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-79 <400> 781 Asn Phe Asp Met Ala 1 5 <210> 782 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-79 <400> 782 Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 783 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-79 <400> 783 His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr 1 5 10 <210> 784 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-79 <400> 784 Arg Ala Ser Gln Gly Ile Ser Asn His Leu Asn 1 5 10 <210> 785 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-79 <400> 785 Tyr Thr Ser Asn Leu Gln Ser 1 5 <210> 786 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-79 <400> 786 Gln Gln Tyr Phe Asp Arg Pro Tyr Thr 1 5 <210> 787 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-79 <400> 787 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 788 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-79 <400> 788 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Gly Ile Ser Asn His 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 35 40 45 Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Phe Asp Arg Pro Tyr 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 789 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-79 scFv <400> 789 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Ser Cys Arg 145 150 155 160 Ala Ser Gln Gly Ile Ser Asn His Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Tyr Phe Asp Arg Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val 225 230 235 240 Glu Ile Lys <210> 790 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-79 HL x CD3 HL molécula biespecífica <400> 790 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Ser Cys Arg 145 150 155 160 Ala Ser Gln Gly Ile Ser Asn His Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Tyr Phe Asp Arg Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 791 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-80 <400> 791 Asn Phe Asp Met Ala 1 5 <210> 792 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-80 <400> 792 Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 793 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-80 <400> 793 His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr 1 5 10 <210> 794 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-80 <400> 794 Arg Ala Ser Gln Gly Ile Ser Asn His Leu Asn 1 5 10 <210> 795 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-80 <400> 795 Tyr Thr Ser Asn Leu Gln Ser 1 5 <210> 796 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-80 <400> 796 Gln Gln Tyr Phe Asp Arg Pro Tyr Thr 1 5 <210> 797 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-80 <400> 797 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 798 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-80 <400> 798 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn His 20 25 30 Leu Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 35 40 45 Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Phe Asp Arg Pro Tyr 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 799 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-80 scFv <400> 799 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Gln Gly Ile Ser Asn His Leu Asn Trp Phe Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Tyr Phe Asp Arg Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val 225 230 235 240 Glu Ile Lys <210> 800 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-80 HL x CD3 HL molécula biespecífica <400> 800 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Gln Gly Ile Ser Asn His Leu Asn Trp Phe Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Tyr Phe Asp Arg Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 801 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-81 <400> 801 Asn Phe Asp Met Ala 1 5 <210> 802 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-81 <400> 802 Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 803 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-81 <400> 803 His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr 1 5 10 <210> 804 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-81 <400> 804 Arg Ala Ser Gln Gly Ile Ser Asn His Leu Asn 1 5 10 <210> 805 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-81 <400> 805 Tyr Thr Ser Asn Leu Gln Ser 1 5 <210> 806 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-81 <400> 806 Gln Gln Tyr Phe Asp Arg Pro Tyr Thr 1 5 <210> 807 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-81 <400> 807 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Ala Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 808 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-81 <400> 808 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Glu Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn His 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 35 40 45 Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Phe Asp Arg Pro Tyr 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 809 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-81 scFv <400> 809 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Ala Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Glu Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Gln Gly Ile Ser Asn His Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Ser Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Tyr Phe Asp Arg Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val 225 230 235 240 Glu Ile Lys <210> 810 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-81 HL x CD3 HL molécula biespecífica <400> 810 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Ala Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Glu Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Gln Gly Ile Ser Asn His Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Ser Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Tyr Phe Asp Arg Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 811 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-82 <400> 811 Asn Phe Asp Met Ala 1 5 <210> 812 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-82 <400> 812 Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 813 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-82 <400> 813 His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr 1 5 10 <210> 814 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-82 <400> 814 Arg Ala Ser Gln Gly Ile Ser Asn His Leu Asn 1 5 10 <210> 815 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-82 <400> 815 Tyr Thr Ser Asn Leu Gln Ser 1 5 <210> 816 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-82 <400> 816 Gln Gln Tyr Ser Asn Leu Pro Tyr Thr 1 5 <210> 817 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-82 <400> 817 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 818 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-82 <400> 818 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Gly Ile Ser Asn His 20 25 30 Leu Asn Trp Phe Gln Gln Lys Pro Gly Arg Ala Pro Lys Pro Leu Ile 35 40 45 Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Leu Pro Tyr 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 819 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-82 scFv <400> 819 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Ser Cys Arg 145 150 155 160 Ala Ser Gln Gly Ile Ser Asn His Leu Asn Trp Phe Gln Gln Lys Pro 165 170 175 Gly Arg Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Tyr Ser Asn Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val 225 230 235 240 Glu Ile Lys <210> 820 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-82 HL x CD3 HL molécula biespecífica <400> 820 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Ser Cys Arg 145 150 155 160 Ala Ser Gln Gly Ile Ser Asn His Leu Asn Trp Phe Gln Gln Lys Pro 165 170 175 Gly Arg Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Tyr Ser Asn Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 821 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-83 <400> 821 Asn Phe Asp Met Ala 1 5 <210> 822 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-83 <400> 822 Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 823 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-83 <400> 823 His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr 1 5 10 <210> 824 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-83 <400> 824 Arg Ala Ser Gln Gly Ile Ser Asn His Leu Asn 1 5 10 <210> 825 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-83 <400> 825 Tyr Thr Ser Asn Leu Gln Ser 1 5 <210> 826 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-83 <400> 826 Gln Gln Tyr Ser Asn Leu Pro Tyr Thr 1 5 <210> 827 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-83 <400> 827 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 828 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-83 <400> 828 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Gly Ile Ser Asn His 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 35 40 45 Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Leu Pro Tyr 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 829 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-83 scFv <400> 829 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Ser Cys Arg 145 150 155 160 Ala Ser Gln Gly Ile Ser Asn His Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Tyr Ser Asn Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val 225 230 235 240 Glu Ile Lys <210> 830 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-83 HL x CD3 HL molécula biespecífica <400> 830 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Ser Cys Arg 145 150 155 160 Ala Ser Gln Gly Ile Ser Asn His Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Tyr Ser Asn Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 831 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-84 <400> 831 Asn Phe Asp Met Ala 1 5 <210> 832 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-84 <400> 832 Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 833 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-84 <400> 833 His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr 1 5 10 <210> 834 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-84 <400> 834 Arg Ala Ser Gln Gly Ile Ser Asn His Leu Asn 1 5 10 <210> 835 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-84 <400> 835 Tyr Thr Ser Asn Leu Gln Ser 1 5 <210> 836 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-84 <400> 836 Gln Gln Tyr Ser Asn Leu Pro Tyr Thr 1 5 <210> 837 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-84 <400> 837 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Ala Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 838 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-84 <400> 838 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Glu Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn His 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 35 40 45 Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Leu Pro Tyr 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 839 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-84 scFv <400> 839 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Ala Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Glu Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Gln Gly Ile Ser Asn His Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Ser Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Tyr Ser Asn Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val 225 230 235 240 Glu Ile Lys <210> 840 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-84 HL x CD3 HL molécula biespecífica <400> 840 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Ala Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Glu Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Gln Gly Ile Ser Asn His Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Ser Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Tyr Ser Asn Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 841 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-85 <400> 841 Asn Phe Gly Met Asn 1 5 <210> 842 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-85 <400> 842 Trp Ile Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Ala Asp Asp Phe Lys 1 5 10 15 Gly <210> 843 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-85 <400> 843 Gly Gly Val Tyr Gly Gly Tyr Asp Ala Met Asp Tyr 1 5 10 <210> 844 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-85 <400> 844 Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 845 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-85 <400> 845 Tyr Thr Ser Arg Leu His Ser 1 5 <210> 846 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-85 <400> 846 Gln Gln Gly Asn Thr Leu Pro Trp Thr 1 5 <210> 847 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-85 <400> 847 Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 20 25 30 Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Ala Asp Asp Phe 50 55 60 Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Thr Thr Ala Tyr 65 70 75 80 Leu Gln Ile Asn Ser Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Val Tyr Gly Gly Tyr Asp Ala Met Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 848 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-85 <400> 848 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Asp Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 849 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-85 scFv <400> 849 Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 20 25 30 Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Ala Asp Asp Phe 50 55 60 Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Thr Thr Ala Tyr 65 70 75 80 Leu Gln Ile Asn Ser Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Val Tyr Gly Gly Tyr Asp Ala Met Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Asp Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 225 230 235 240 Glu Ile Lys <210> 850 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-85 HL x CD3 HL molécula biespecífica <400> 850 Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 20 25 30 Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Ala Asp Asp Phe 50 55 60 Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Thr Thr Ala Tyr 65 70 75 80 Leu Gln Ile Asn Ser Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Val Tyr Gly Gly Tyr Asp Ala Met Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Asp Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 851 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-86 <400> 851 Asn Phe Gly Met Asn 1 5 <210> 852 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-86 <400> 852 Trp Ile Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Ala Asp Asp Phe Lys 1 5 10 15 Gly <210> 853 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-86 <400> 853 Gly Gly Val Tyr Gly Gly Tyr Asp Ala Met Asp Tyr 1 5 10 <210> 854 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-86 <400> 854 Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 855 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-86 <400> 855 Tyr Thr Ser Arg Leu His Ser 1 5 <210> 856 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-86 <400> 856 Gln Gln Gly Asn Thr Leu Pro Trp Thr 1 5 <210> 857 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-86 <400> 857 Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 20 25 30 Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Ala Asp Asp Phe 50 55 60 Lys Gly Arg Phe Val Phe Ser Ser Asp Thr Ser Val Ser Thr Ala Tyr 65 70 75 80 Leu Gln Ile Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Arg Gly Gly Val Tyr Gly Gly Tyr Asp Ala Met Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 858 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-86 <400> 858 Asp Ile Gln Met Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Leu Lys Leu Leu Ile 35 40 45 Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 859 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-86 scFv <400> 859 Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 20 25 30 Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Ala Asp Asp Phe 50 55 60 Lys Gly Arg Phe Val Phe Ser Ser Asp Thr Ser Val Ser Thr Ala Tyr 65 70 75 80 Leu Gln Ile Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Arg Gly Gly Val Tyr Gly Gly Tyr Asp Ala Met Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Thr Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Leu Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 195 200 205 Leu Thr Ile Ser Asn Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 225 230 235 240 Glu Ile Lys <210> 860 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-86 HL x CD3 HL molécula biespecífica <400> 860 Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 20 25 30 Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Ala Asp Asp Phe 50 55 60 Lys Gly Arg Phe Val Phe Ser Ser Asp Thr Ser Val Ser Thr Ala Tyr 65 70 75 80 Leu Gln Ile Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Arg Gly Gly Val Tyr Gly Gly Tyr Asp Ala Met Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Thr Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Leu Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 195 200 205 Leu Thr Ile Ser Asn Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 861 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-87 <400> 861 Asn Phe Gly Met Asn 1 5 <210> 862 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-87 <400> 862 Trp Ile Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Ala Asp Asp Phe Lys 1 5 10 15 Gly <210> 863 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-87 <400> 863 Gly Gly Val Tyr Gly Gly Tyr Asp Ala Met Asp Tyr 1 5 10 <210> 864 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-87 <400> 864 Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 865 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-87 <400> 865 Tyr Thr Ser Arg Leu His Ser 1 5 <210> 866 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-87 <400> 866 Gln Gln Gly Asn Thr Leu Pro Trp Thr 1 5 <210> 867 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-87 <400> 867 Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 20 25 30 Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Ala Asp Asp Phe 50 55 60 Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Thr Thr Ala Tyr 65 70 75 80 Leu Gln Ile Asn Ser Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Val Tyr Gly Gly Tyr Asp Ala Met Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 868 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-87 <400> 868 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Gln 65 70 75 80 Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 869 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-87 scFv <400> 869 Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 20 25 30 Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Ala Asp Asp Phe 50 55 60 Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Thr Thr Ala Tyr 65 70 75 80 Leu Gln Ile Asn Ser Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Val Tyr Gly Gly Tyr Asp Ala Met Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys 210 215 220 Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 225 230 235 240 Glu Ile Lys <210> 870 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-87 HL x CD3 HL molécula biespecífica <400> 870 Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 20 25 30 Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Ala Asp Asp Phe 50 55 60 Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Thr Thr Ala Tyr 65 70 75 80 Leu Gln Ile Asn Ser Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Val Tyr Gly Gly Tyr Asp Ala Met Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys 210 215 220 Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 871 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-88 <400> 871 Asn Phe Gly Met Asn 1 5 <210> 872 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-88 <400> 872 Trp Ile Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Ala Asp Asp Phe Lys 1 5 10 15 Gly <210> 873 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-88 <400> 873 Gly Gly Val Tyr Gly Gly Tyr Asp Ala Met Asp Tyr 1 5 10 <210> 874 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-88 <400> 874 Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 875 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-88 <400> 875 Tyr Thr Ser Arg Leu His Ser 1 5 <210> 876 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-88 <400> 876 Gln Ser Phe Ala Thr Leu Pro Trp Thr 1 5 <210> 877 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-88 <400> 877 Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 20 25 30 Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Ala Asp Asp Phe 50 55 60 Lys Gly Arg Phe Val Phe Ser Ser Asp Thr Ser Val Ser Thr Ala Tyr 65 70 75 80 Leu Gln Ile Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Arg Gly Gly Val Tyr Gly Gly Tyr Asp Ala Met Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 878 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-88 <400> 878 Asp Ile Gln Met Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Leu Lys Leu Leu Ile 35 40 45 Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Ser Phe Ala Thr Leu Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 879 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-88 scFv <400> 879 Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 20 25 30 Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Ala Asp Asp Phe 50 55 60 Lys Gly Arg Phe Val Phe Ser Ser Asp Thr Ser Val Ser Thr Ala Tyr 65 70 75 80 Leu Gln Ile Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Arg Gly Gly Val Tyr Gly Gly Tyr Asp Ala Met Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Thr Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Leu Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 195 200 205 Leu Thr Ile Ser Asn Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 210 215 220 Gln Ser Phe Ala Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 225 230 235 240 Glu Ile Lys <210> 880 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-88 HL x CD3 HL molécula biespecífica <400> 880 Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 20 25 30 Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Ala Asp Asp Phe 50 55 60 Lys Gly Arg Phe Val Phe Ser Ser Asp Thr Ser Val Ser Thr Ala Tyr 65 70 75 80 Leu Gln Ile Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Arg Gly Gly Val Tyr Gly Gly Tyr Asp Ala Met Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Thr Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Leu Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 195 200 205 Leu Thr Ile Ser Asn Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 210 215 220 Gln Ser Phe Ala Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 881 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-89 <400> 881 Asn Phe Gly Met Asn 1 5 <210> 882 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-89 <400> 882 Trp Ile Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Ala Asp Asp Phe Lys 1 5 10 15 Gly <210> 883 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-89 <400> 883 Gly Gly Val Tyr Gly Gly Tyr Asp Ala Met Asp Tyr 1 5 10 <210> 884 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-89 <400> 884 Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 885 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-89 <400> 885 Tyr Thr Ser Arg Leu His Ser 1 5 <210> 886 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-89 <400> 886 Gln Ser Phe Ala Thr Leu Pro Trp Thr 1 5 <210> 887 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-89 <400> 887 Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 20 25 30 Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Ala Asp Asp Phe 50 55 60 Lys Gly Arg Phe Val Phe Ser Ser Asp Thr Ser Val Ser Thr Ala Tyr 65 70 75 80 Leu Gln Ile Asn Asn Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Val Tyr Gly Gly Tyr Asp Ala Met Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 888 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-89 <400> 888 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Asn Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Ser Phe Ala Thr Leu Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 889 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-89 scFv <400> 889 Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 20 25 30 Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Ala Asp Asp Phe 50 55 60 Lys Gly Arg Phe Val Phe Ser Ser Asp Thr Ser Val Ser Thr Ala Tyr 65 70 75 80 Leu Gln Ile Asn Asn Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Val Tyr Gly Gly Tyr Asp Ala Met Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Ser Cys Arg 145 150 155 160 Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Phe Thr Ile Ser Asn Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 210 215 220 Gln Ser Phe Ala Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 225 230 235 240 Glu Ile Lys <210> 890 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-89 HL x CD3 HL molécula biespecífica <400> 890 Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 20 25 30 Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Ala Asp Asp Phe 50 55 60 Lys Gly Arg Phe Val Phe Ser Ser Asp Thr Ser Val Ser Thr Ala Tyr 65 70 75 80 Leu Gln Ile Asn Asn Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Val Tyr Gly Gly Tyr Asp Ala Met Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Ser Cys Arg 145 150 155 160 Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Phe Thr Ile Ser Asn Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 210 215 220 Gln Ser Phe Ala Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 891 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-90 <400> 891 Asn Phe Gly Met Asn 1 5 <210> 892 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-90 <400> 892 Trp Ile Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Ala Asp Asp Phe Lys 1 5 10 15 Gly <210> 893 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-90 <400> 893 Gly Gly Val Tyr Gly Gly Tyr Asp Ala Met Asp Tyr 1 5 10 <210> 894 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-90 <400> 894 Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 895 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-90 <400> 895 Tyr Thr Ser Arg Leu His Ser 1 5 <210> 896 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-90 <400> 896 Gln Ser Phe Ala Thr Leu Pro Trp Thr 1 5 <210> 897 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-90 <400> 897 Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 20 25 30 Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Ala Asp Asp Phe 50 55 60 Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Thr Thr Ala Tyr 65 70 75 80 Leu Gln Ile Asn Ser Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Val Tyr Gly Gly Tyr Asp Ala Met Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 898 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-90 <400> 898 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Asp Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Ser Phe Ala Thr Leu Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 899 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-90 scFv <400> 899 Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 20 25 30 Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Ala Asp Asp Phe 50 55 60 Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Thr Thr Ala Tyr 65 70 75 80 Leu Gln Ile Asn Ser Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Val Tyr Gly Gly Tyr Asp Ala Met Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Asp Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 210 215 220 Gln Ser Phe Ala Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 225 230 235 240 Glu Ile Lys <210> 900 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-90 HL x CD3 HL molécula biespecífica <400> 900 Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 20 25 30 Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Ala Asp Asp Phe 50 55 60 Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Thr Thr Ala Tyr 65 70 75 80 Leu Gln Ile Asn Ser Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Val Tyr Gly Gly Tyr Asp Ala Met Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Asp Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 210 215 220 Gln Ser Phe Ala Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 901 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-91 <400> 901 Asn Phe Gly Met Asn 1 5 <210> 902 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-91 <400> 902 Trp Ile Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Ala Asp Asp Phe Lys 1 5 10 15 Gly <210> 903 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-91 <400> 903 Gly Gly Val Tyr Gly Gly Tyr Asp Ala Met Asp Tyr 1 5 10 <210> 904 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-91 <400> 904 Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 905 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-91 <400> 905 Tyr Thr Ser Arg Leu His Ser 1 5 <210> 906 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-91 <400> 906 Gln Ser Phe Ala Thr Leu Pro Trp Thr 1 5 <210> 907 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-91 <400> 907 Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 20 25 30 Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Ala Asp Asp Phe 50 55 60 Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Thr Thr Ala Tyr 65 70 75 80 Leu Gln Ile Asn Ser Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Val Tyr Gly Gly Tyr Asp Ala Met Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 908 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-91 <400> 908 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Gln 65 70 75 80 Glu Asp Ile Ala Thr Tyr Phe Cys Gln Ser Phe Ala Thr Leu Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 909 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-91 scFv <400> 909 Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 20 25 30 Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Ala Asp Asp Phe 50 55 60 Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Thr Thr Ala Tyr 65 70 75 80 Leu Gln Ile Asn Ser Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Val Tyr Gly Gly Tyr Asp Ala Met Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys 210 215 220 Gln Ser Phe Ala Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 225 230 235 240 Glu Ile Lys <210> 910 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-91 HL x CD3 HL molécula biespecífica <400> 910 Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 20 25 30 Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Ala Asp Asp Phe 50 55 60 Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Thr Thr Ala Tyr 65 70 75 80 Leu Gln Ile Asn Ser Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Val Tyr Gly Gly Tyr Asp Ala Met Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys 210 215 220 Gln Ser Phe Ala Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 911 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-92 <400> 911 Asn Phe Gly Met Asn 1 5 <210> 912 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-92 <400> 912 Trp Ile Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Ala Asp Asp Phe Lys 1 5 10 15 Gly <210> 913 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-92 <400> 913 Gly Gly Val Tyr Gly Gly Tyr Asp Ala Met Asp Tyr 1 5 10 <210> 914 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-92 <400> 914 Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 915 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-92 <400> 915 Tyr Thr Ser Arg Leu His Ser 1 5 <210> 916 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-92 <400> 916 Gln His Phe Arg Thr Leu Pro Trp Thr 1 5 <210> 917 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-92 <400> 917 Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 20 25 30 Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Ala Asp Asp Phe 50 55 60 Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Thr Thr Ala Tyr 65 70 75 80 Leu Gln Ile Asn Ser Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Val Tyr Gly Gly Tyr Asp Ala Met Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 918 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-92 <400> 918 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Asp Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Tyr Cys Gln His Phe Arg Thr Leu Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 919 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-92 scFv <400> 919 Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 20 25 30 Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Ala Asp Asp Phe 50 55 60 Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Thr Thr Ala Tyr 65 70 75 80 Leu Gln Ile Asn Ser Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Val Tyr Gly Gly Tyr Asp Ala Met Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Asp Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 210 215 220 Gln His Phe Arg Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 225 230 235 240 Glu Ile Lys <210> 920 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-92 HL x CD3 HL molécula biespecífica <400> 920 Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 20 25 30 Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Ala Asp Asp Phe 50 55 60 Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Thr Thr Ala Tyr 65 70 75 80 Leu Gln Ile Asn Ser Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Val Tyr Gly Gly Tyr Asp Ala Met Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Asp Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 210 215 220 Gln His Phe Arg Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 921 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-93 <400> 921 Asn Phe Gly Met Asn 1 5 <210> 922 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-93 <400> 922 Trp Ile Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Ala Asp Asp Phe Lys 1 5 10 15 Gly <210> 923 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-93 <400> 923 Gly Gly Val Tyr Gly Gly Tyr Asp Ala Met Asp Tyr 1 5 10 <210> 924 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-93 <400> 924 Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 925 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-93 <400> 925 Tyr Thr Ser Arg Leu His Ser 1 5 <210> 926 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-93 <400> 926 Gln His Phe Arg Thr Leu Pro Trp Thr 1 5 <210> 927 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-93 <400> 927 Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 20 25 30 Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Ala Asp Asp Phe 50 55 60 Lys Gly Arg Phe Val Phe Ser Ser Asp Thr Ser Val Ser Thr Ala Tyr 65 70 75 80 Leu Gln Ile Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Arg Gly Gly Val Tyr Gly Gly Tyr Asp Ala Met Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 928 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-93 <400> 928 Asp Ile Gln Met Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Leu Lys Leu Leu Ile 35 40 45 Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Tyr Cys Gln His Phe Arg Thr Leu Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 929 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-93 scFv <400> 929 Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 20 25 30 Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Ala Asp Asp Phe 50 55 60 Lys Gly Arg Phe Val Phe Ser Ser Asp Thr Ser Val Ser Thr Ala Tyr 65 70 75 80 Leu Gln Ile Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Arg Gly Gly Val Tyr Gly Gly Tyr Asp Ala Met Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Thr Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Leu Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 195 200 205 Leu Thr Ile Ser Asn Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 210 215 220 Gln His Phe Arg Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 225 230 235 240 Glu Ile Lys <210> 930 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-93 HL x CD3 HL molécula biespecífica <400> 930 Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 20 25 30 Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Ala Asp Asp Phe 50 55 60 Lys Gly Arg Phe Val Phe Ser Ser Asp Thr Ser Val Ser Thr Ala Tyr 65 70 75 80 Leu Gln Ile Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Arg Gly Gly Val Tyr Gly Gly Tyr Asp Ala Met Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Thr Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Leu Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 195 200 205 Leu Thr Ile Ser Asn Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 210 215 220 Gln His Phe Arg Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 931 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-94 <400> 931 Asn Phe Gly Met Asn 1 5 <210> 932 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-94 <400> 932 Trp Ile Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Ala Asp Asp Phe Lys 1 5 10 15 Gly <210> 933 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-94 <400> 933 Gly Gly Val Tyr Gly Gly Tyr Asp Ala Met Asp Tyr 1 5 10 <210> 934 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-94 <400> 934 Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 935 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-94 <400> 935 Tyr Thr Ser Arg Leu His Ser 1 5 <210> 936 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-94 <400> 936 Gln His Phe Arg Thr Leu Pro Trp Thr 1 5 <210> 937 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-94 <400> 937 Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 20 25 30 Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Ala Asp Asp Phe 50 55 60 Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Thr Thr Ala Tyr 65 70 75 80 Leu Gln Ile Asn Ser Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Val Tyr Gly Gly Tyr Asp Ala Met Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 938 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-94 <400> 938 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Gln 65 70 75 80 Glu Asp Ile Ala Thr Tyr Phe Cys Gln His Phe Arg Thr Leu Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 939 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-94 scFv <400> 939 Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 20 25 30 Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Ala Asp Asp Phe 50 55 60 Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Thr Thr Ala Tyr 65 70 75 80 Leu Gln Ile Asn Ser Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Val Tyr Gly Gly Tyr Asp Ala Met Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys 210 215 220 Gln His Phe Arg Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 225 230 235 240 Glu Ile Lys <210> 940 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-94 HL x CD3 HL molécula biespecífica <400> 940 Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 20 25 30 Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Ala Asp Asp Phe 50 55 60 Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Thr Thr Ala Tyr 65 70 75 80 Leu Gln Ile Asn Ser Leu Lys Asp Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Val Tyr Gly Gly Tyr Asp Ala Met Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys 210 215 220 Gln His Phe Arg Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 941 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-95 <400> 941 Asn Phe Gly Met Asn 1 5 <210> 942 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-95 <400> 942 Trp Ile Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Ala Asp Asp Phe Lys 1 5 10 15 Gly <210> 943 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-95 <400> 943 Gly Gly Val Tyr Gly Gly Tyr Asp Ala Met Asp Tyr 1 5 10 <210> 944 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-95 <400> 944 Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 945 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-95 <400> 945 Tyr Thr Ser Arg Leu His Ser 1 5 <210> 946 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-95 <400> 946 Gln His Phe Arg Thr Leu Pro Trp Thr 1 5 <210> 947 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-95 <400> 947 Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 20 25 30 Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Ala Asp Asp Phe 50 55 60 Lys Gly Arg Phe Val Phe Ser Ser Asp Thr Ser Val Ser Thr Ala Tyr 65 70 75 80 Leu Gln Ile Asn Asn Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Val Tyr Gly Gly Tyr Asp Ala Met Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 948 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-95 <400> 948 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Asn Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Phe Cys Gln His Phe Arg Thr Leu Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 949 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-95 scFv <400> 949 Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 20 25 30 Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Ala Asp Asp Phe 50 55 60 Lys Gly Arg Phe Val Phe Ser Ser Asp Thr Ser Val Ser Thr Ala Tyr 65 70 75 80 Leu Gln Ile Asn Asn Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Val Tyr Gly Gly Tyr Asp Ala Met Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Ser Cys Arg 145 150 155 160 Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Phe Thr Ile Ser Asn Leu Gln Pro Glu Asp Ile Ala Thr Tyr Phe Cys 210 215 220 Gln His Phe Arg Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 225 230 235 240 Glu Ile Lys <210> 950 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-95 HL x CD3 HL molécula biespecífica <400> 950 Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 20 25 30 Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Ala Asp Asp Phe 50 55 60 Lys Gly Arg Phe Val Phe Ser Ser Asp Thr Ser Val Ser Thr Ala Tyr 65 70 75 80 Leu Gln Ile Asn Asn Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Val Tyr Gly Gly Tyr Asp Ala Met Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Ser Cys Arg 145 150 155 160 Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Phe Thr Ile Ser Asn Leu Gln Pro Glu Asp Ile Ala Thr Tyr Phe Cys 210 215 220 Gln His Phe Arg Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 951 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-96 <400> 951 Asn Phe Gly Met Asn 1 5 <210> 952 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-96 <400> 952 Trp Ile Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Ala Asp Asp Phe Lys 1 5 10 15 Gly <210> 953 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-96 <400> 953 Gly Gly Val Tyr Gly Gly Tyr Asp Ala Met Asp Tyr 1 5 10 <210> 954 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-96 <400> 954 Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 955 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-96 <400> 955 Tyr Thr Ser Arg Leu His Ser 1 5 <210> 956 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-96 <400> 956 Gln Gln Gly Asn Thr Leu Pro Trp Thr 1 5 <210> 957 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-96 <400> 957 Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 20 25 30 Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Ala Asp Asp Phe 50 55 60 Lys Gly Arg Phe Val Phe Ser Ser Asp Thr Ser Val Ser Thr Ala Tyr 65 70 75 80 Leu Gln Ile Asn Asn Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Val Tyr Gly Gly Tyr Asp Ala Met Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 958 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-96 <400> 958 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Asn Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 959 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-96 de scFv <400> 959 Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 20 25 30 Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Ala Asp Asp Phe 50 55 60 Lys Gly Arg Phe Val Phe Ser Ser Asp Thr Ser Val Ser Thr Ala Tyr 65 70 75 80 Leu Gln Ile Asn Asn Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Val Tyr Gly Gly Tyr Asp Ala Met Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Ser Cys Arg 145 150 155 160 Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Phe Thr Ile Ser Asn Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 225 230 235 240 Glu Ile Lys <210> 960 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-96 HL x CD3 HL molécula biespecífica <400> 960 Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 20 25 30 Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Ala Asp Asp Phe 50 55 60 Lys Gly Arg Phe Val Phe Ser Ser Asp Thr Ser Val Ser Thr Ala Tyr 65 70 75 80 Leu Gln Ile Asn Asn Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Val Tyr Gly Gly Tyr Asp Ala Met Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Ser Cys Arg 145 150 155 160 Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Phe Thr Ile Ser Asn Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 961 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-97 <400> 961 Asn Phe Asp Met Ala 1 5 <210> 962 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-97 <400> 962 Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 963 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-97 <400> 963 His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr 1 5 10 <210> 964 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-97 <400> 964 Arg Ala Ser Gln Gly Ile Ser Asn Asn Leu Asn 1 5 10 <210> 965 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-97 <400> 965 Tyr Thr Ser Asn Leu Gln Ser 1 5 <210> 966 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-97 <400> 966 Gln Gln Phe Thr Ser Leu Pro Tyr Thr 1 5 <210> 967 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-97 <400> 967 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 968 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-97 <400> 968 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Asn 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 35 40 45 Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Thr Ser Leu Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 969 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-97 scFv <400> 969 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Met Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Gln Gly Ile Ser Asn Asn Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Ser Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Phe Thr Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu 225 230 235 240 Glu Ile Lys <210> 970 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-97 HL x CD3 HL molécula biespecífica <400> 970 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Met Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Gln Gly Ile Ser Asn Asn Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Ser Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Phe Thr Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 971 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-98 <400> 971 Asn Phe Asp Met Ala 1 5 <210> 972 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-98 <400> 972 Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 973 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-98 <400> 973 His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr 1 5 10 <210> 974 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-98 <400> 974 Arg Ala Asn Gln Gly Ile Ser Asn Asn Leu Asn 1 5 10 <210> 975 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-98 <400> 975 Tyr Thr Ser Asn Leu Gln Ser 1 5 <210> 976 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-98 <400> 976 Gln Gln Phe Thr Ser Leu Pro Tyr Thr 1 5 <210> 977 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-98 <400> 977 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Tyr 65 70 75 80 Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 978 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-98 <400> 978 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Asn Gln Gly Ile Ser Asn Asn 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 35 40 45 Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Thr Ser Leu Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 979 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-98 scFv <400> 979 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Tyr 65 70 75 80 Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Asn Gln Gly Ile Ser Asn Asn Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Phe Thr Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu 225 230 235 240 Glu Ile Lys <210> 980 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-98 HL x CD3 HL molécula biespecífica <400> 980 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Tyr 65 70 75 80 Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Asn Gln Gly Ile Ser Asn Asn Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Phe Thr Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 981 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-99 <400> 981 Asn Phe Asp Met Ala 1 5 <210> 982 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-99 <400> 982 Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 983 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-99 <400> 983 His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr 1 5 10 <210> 984 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-99 <400> 984 Arg Ala Ser Gln Gly Ile Ser Asn Asn Leu Asn 1 5 10 <210> 985 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-99 <400> 985 Tyr Thr Ser Asn Leu Gln Ser 1 5 <210> 986 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-99 <400> 986 Gln Gln Phe Thr Ser Leu Pro Tyr Thr 1 5 <210> 987 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-99 <400> 987 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 988 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-99 <400> 988 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Asn 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 35 40 45 Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Thr Ser Leu Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 989 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-99 scFv <400> 989 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Met Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Gln Gly Ile Ser Asn Asn Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Ser Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Phe Thr Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu 225 230 235 240 Glu Ile Lys <210> 990 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-99 HL x CD3 HL molécula biespecífica <400> 990 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Met Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Gln Gly Ile Ser Asn Asn Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Ser Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Phe Thr Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 991 <211> 5 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-100 <400> 991 Asn Phe Asp Met Ala 1 5 <210> 992 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-100 <400> 992 Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 993 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-100 <400> 993 His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr 1 5 10 <210> 994 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-100 <400> 994 Arg Ala Ser Gln Gly Ile Ser Asn Asn Leu Asn 1 5 10 <210> 995 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-100 <400> 995 Tyr Thr Ser Asn Leu Gln Ser 1 5 <210> 996 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-100 <400> 996 Gln Gln Phe Ala His Leu Pro Tyr Thr 1 5 <210> 997 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-100 <400> 997 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 998 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-100 <400> 998 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Asn 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 35 40 45 Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Ala His Leu Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 999 <211> 243 <212> PRT <213> artificial <220> <223> BCMA-100 scFv <400> 999 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Met Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Gln Gly Ile Ser Asn Asn Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Ser Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Phe Ala His Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu 225 230 235 240 Glu Ile Lys <210> 1000 <211> 498 <212> PRT <213> artificial <220> <223> BCMA-100 HL x CD3 HL molécula biespecífica <400> 1000 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 130 135 140 Ser Ser Met Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 145 150 155 160 Ala Ser Gln Gly Ile Ser Asn Asn Leu Asn Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Ser Leu Ile Tyr Tyr Thr Ser Asn Leu Gln Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Phe Ala His Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu 225 230 235 240 Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 245 250 255 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 260 265 270 Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 275 280 285 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 290 295 300 Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 305 310 315 320 Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 325 330 335 Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 340 345 350 Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 385 390 395 400 Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 405 410 415 Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 420 425 430 Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 435 440 445 Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 450 455 460 Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 465 470 475 480 Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 485 490 495 Val Leu <210> 1001 <211> 555 <212> DNA <213> humano <220> <221> misc <222> (1)..(555) <223> BCMA humano <400> 1001 atgttgcaga tggctgggca gtgctcccaa aatgaatatt ttgacagttt gttgcatgct 60 tgcatacctt gtcaacttcg atgttcttct aatactcctc ctctaacatg tcagcgttat 120 tgtaatgcaa gtgtgaccaa ttcagtgaaa ggaacgaatg cgattctctg gacctgtttg 180 ggactgagct taataatttc tttggcagtt ttcgtgctaa tgtttttgct aaggaagata 240 aactctgaac cattaaagga cgagtttaaa aacacaggat caggtctcct gggcatggct 300 aacattgacc tggaaaagag caggactggt gatgaaatta ttcttccgag aggcctcgag 360 tacacggtgg aagaatgcac ctgtgaagac tgcatcaaga gcaaaccgaa ggtcgactct 420 gaccattgct ttccactccc agctatggag gaaggcgcaa ccattcttgt caccacgaaa 480 acgaatgact attgcaagag cctgccagct gctttgagtg ctacggagat agagaaatca 540 atttctgcta ggtaa 555 <210> 1002 <211> 184 <212> PRT <213> humano <220> <221> misc <222> (1)..(184) <223> BCMA humano <400> 1002 Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 1 5 10 15 Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 20 25 30 Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser 35 40 45 Val Lys Gly Thr Asn Ala Ile Leu Trp Thr Cys Leu Gly Leu Ser Leu 50 55 60 Ile Ile Ser Leu Ala Val Phe Val Leu Met Phe Leu Leu Arg Lys Ile 65 70 75 80 Asn Ser Glu Pro Leu Lys Asp Glu Phe Lys Asn Thr Gly Ser Gly Leu 85 90 95 Leu Gly Met Ala Asn Ile Asp Leu Glu Lys Ser Arg Thr Gly Asp Glu 100 105 110 Ile Ile Leu Pro Arg Gly Leu Glu Tyr Thr Val Glu Glu Cys Thr Cys 115 120 125 Glu Asp Cys Ile Lys Ser Lys Pro Lys Val Asp Ser Asp His Cys Phe 130 135 140 Pro Leu Pro Ala Met Glu Glu Gly Ala Thr Ile Leu Val Thr Thr Lys 145 150 155 160 Thr Asn Asp Tyr Cys Lys Ser Leu Pro Ala Ala Leu Ser Ala Thr Glu 165 170 175 Ile Glu Lys Ser Ile Ser Ala Arg 180 <210> 1003 <211> 558 <212> DNA <213> ratón <220> <221> misc <222> (1)..(558) <223> BCMA de ratón <400> 1003 atggcgcaac agtgtttcca cagtgaatat tttgacagtc tgctgcatgc ttgcaaaccg 60 tgtcacttgc gatgttccaa ccctcctgca acctgtcagc cttactgtga tccaagcgtg 120 accagttcag tgaaagggac gtacacggtg ctctggatct tcttggggct gaccttggtc 180 ctctctttgg cacttttcac aatctcattc ttgctgagga agatgaaccc cgaggccctg 240 aaggacgagc ctcaaagccc aggtcagctt gacggatcgg ctcagctgga caaggccgac 300 accgagctga ctaggatcag ggctggtgac gacaggatct ttccccgaag cctggagtat 360 acagtggaag agtgcacctg tgaggactgt gtcaagagca aacccaaggg ggattctgac 420 catttcttcc cgcttccagc catggaggag ggggcaacca ttcttgtcac cacaaaaacg 480 ggtgactacg gcaagtcaag tgtgccaact gctttgcaaa gtgtcatggg gatggagaag 540 ccaactcaca ctagataa 558 <210> 1004 <211> 185 <212> PRT <213> ratón <220> <221> misc <222> (1)..(185) <223> BCMA de ratón <400> 1004 Met Ala Gln Gln Cys Phe His Ser Glu Tyr Phe Asp Ser Leu Leu His 1 5 10 15 Ala Cys Lys Pro Cys His Leu Arg Cys Ser Asn Pro Pro Ala Thr Cys 20 25 30 Gln Pro Tyr Cys Asp Pro Ser Val Thr Ser Ser Val Lys Gly Thr Tyr 35 40 45 Thr Val Leu Trp Ile Phe Leu Gly Leu Thr Leu Val Leu Ser Leu Ala 50 55 60 Leu Phe Thr Ile Ser Phe Leu Leu Arg Lys Met Asn Pro Glu Ala Leu 65 70 75 80 Lys Asp Glu Pro Gln Ser Pro Gly Gln Leu Asp Gly Ser Ala Gln Leu 85 90 95 Asp Lys Ala Asp Thr Glu Leu Thr Arg Ile Arg Ala Gly Asp Asp Arg 100 105 110 Ile Phe Pro Arg Ser Leu Glu Tyr Thr Val Glu Glu Cys Thr Cys Glu 115 120 125 Asp Cys Val Lys Ser Lys Pro Lys Gly Asp Ser Asp His Phe Phe Pro 130 135 140 Leu Pro Ala Met Glu Glu Gly Ala Thr Ile Leu Val Thr Thr Lys Thr 145 150 155 160 Gly Asp Tyr Gly Lys Ser Ser Val Pro Thr Ala Leu Gln Ser Val Met 165 170 175 Gly Met Glu Lys Pro Thr His Thr Arg 180 185 <210> 1005 <211> 552 <212> DNA <213> mono rhesus <220> <221> misc <222> (1)..(552) <223> BCMA de mono rhesus <400> 1005 atgttgcaga tggctcggca gtgctcccaa aatgaatatt ttgacagttt gttgcatgat 60 tgcaaacctt gtcaacttcg atgttctagt actcctcctc taacatgtca gcgttattgc 120 aatgcaagta tgaccaattc agtgaaagga atgaatgcga ttctctggac ctgtttggga 180 ctgagcttga taatttcttt ggcagttttc gtgctaacgt ttttgctaag gaagatgagc 240 tctgaaccat taaaggatga gtttaaaaac acaggatcag gtctcctggg catggctaac 300 attgacctgg aaaagggcag gactggtgat gaaattgttc ttccaagagg cctggagtac 360 acggtggaag aatgcacctg tgaagactgc atcaagaata aaccaaaggt tgattctgac 420 cattgctttc cactcccagc catggaggaa ggcgcaacca ttctcgtcac cacgaaaacg 480 aatgactatt gcaatagcct gtcagctgct ttgagtgtta cggagataga gaaatcaatt 540 tctgctaggt aa 552 <210> 1006 <211> 183 <212> PRT <213> mono rhesus <220> <221> misc <222> (1)..(183) <223> BCMA de mono rhesus <400> 1006 Met Leu Gln Met Ala Arg Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 1 5 10 15 Leu Leu His Asp Cys Lys Pro Cys Gln Leu Arg Cys Ser Ser Thr Pro 20 25 30 Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Met Thr Asn Ser Val 35 40 45 Lys Gly Met Asn Ala Ile Leu Trp Thr Cys Leu Gly Leu Ser Leu Ile 50 55 60 Ile Ser Leu Ala Val Phe Val Leu Thr Phe Leu Leu Arg Lys Met Ser 65 70 75 80 Ser Glu Pro Leu Lys Asp Glu Phe Lys Asn Thr Gly Ser Gly Leu Leu 85 90 95 Gly Met Ala Asn Ile Asp Leu Glu Lys Gly Arg Thr Gly Asp Glu Ile 100 105 110 Val Leu Pro Arg Gly Leu Glu Tyr Thr Val Glu Glu Cys Thr Cys Glu 115 120 125 Asp Cys Ile Lys Asn Lys Pro Lys Val Asp Ser Asp His Cys Phe Pro 130 135 140 Leu Pro Ala Met Glu Glu Gly Ala Thr Ile Leu Val Thr Thr Lys Thr 145 150 155 160 Asn Asp Tyr Cys Asn Ser Leu Ser Ala Ala Leu Ser Val Thr Glu Ile 165 170 175 Glu Lys Ser Ile Ser Ala Arg 180 <210> 1007 <211> 54 <212> PRT <213> humano <220> <221> misc <222> (1)..(54) <223> BCMA humano <400> 1007 Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 1 5 10 15 Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 20 25 30 Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser 35 40 45 Val Lys Gly Thr Asn Ala 50 <210> 1008 <211> 49 <212> PRT <213> ratón <220> <221> misc <222> (1)..(49) <223> BCMA de ratón <400> 1008 Met Ala Gln Gln Cys Phe His Ser Glu Tyr Phe Asp Ser Leu Leu His 1 5 10 15 Ala Cys Lys Pro Cys His Leu Arg Cys Ser Asn Pro Pro Ala Thr Cys 20 25 30 Gln Pro Tyr Cys Asp Pro Ser Val Thr Ser Ser Val Lys Gly Thr Tyr 35 40 45 Thr <210> 1009 <211> 51 <212> PRT <213> artificial <220> <223> quimera BCMA humano/ratón <400> 1009 Met Ala Gln Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu Leu His 1 5 10 15 Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro Pro Leu 20 25 30 Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val Lys Gly 35 40 45 Thr Asn Ala 50 <210> 1010 <211> 54 <212> PRT <213> artificial <220> <223> quimera BCMA humano/ratón <400> 1010 Met Leu Gln Met Ala Gly Gln Cys Phe His Ser Glu Tyr Phe Asp Ser 1 5 10 15 Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 20 25 30 Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser 35 40 45 Val Lys Gly Thr Asn Ala 50 <210> 1011 <211> 52 <212> PRT <213> artificial <220> <223> quimera BCMA humano/ratón <400> 1011 Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 1 5 10 15 Leu Leu His Ala Cys Ile Pro Cys His Leu Arg Cys Ser Asn Pro Pro 20 25 30 Ala Thr Cys Gln Pro Tyr Cys Asn Ala Ser Val Thr Asn Ser Val Lys 35 40 45 Gly Thr Asn Ala 50 <210> 1012 <211> 54 <212> PRT <213> artificial <220> <223> quimera BCMA humano/ratón <400> 1012 Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 1 5 10 15 Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 20 25 30 Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asp Pro Ser Val Thr Ser Ser 35 40 45 Val Lys Gly Thr Tyr Thr 50 <210> 1013 <211> 54 <212> PRT <213> artificial <220> <223> quimera BCMA humano/ratón <400> 1013 Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 1 5 10 15 Leu Leu His Ala Cys Lys Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 20 25 30 Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser 35 40 45 Val Lys Gly Thr Asn Ala 50 <210> 1014 <211> 54 <212> PRT <213> artificial <220> <223> quimera BCMA humano/ratón <400> 1014 Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 1 5 10 15 Leu Leu His Ala Cys Ile Pro Cys His Leu Arg Cys Ser Ser Asn Thr 20 25 30 Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser 35 40 45 Val Lys Gly Thr Asn Ala 50 <210> 1015 <211> 54 <212> PRT <213> artificial <220> <223> quimera BCMA humano/ratón <400> 1015 Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 1 5 10 15 Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 20 25 30 Pro Pro Leu Thr Cys Gln Pro Tyr Cys Asn Ala Ser Val Thr Asn Ser 35 40 45 Val Lys Gly Thr Asn Ala 50 <210> 1016 <211> 18 <212> PRT <213> humano <220> <221> misc <222> (1)..(18) <223> BCMA humano <400> 1016 Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro Pro Leu Thr Cys Gln Arg 1 5 10 15 Tyr Cys <210> 1017 <211> 17 <212> PRT <213> mono rhesus <220> <221> misc <222> (1)..(17) <223> BCMA de mono rhesus <400> 1017 Cys Gln Leu Arg Cys Ser Ser Thr Pro Pro Leu Thr Cys Gln Arg Tyr 1 5 10 15 Cys <210> 1018 <211> 7 <212> PRT <213> humano <220> <221> misc <222> (1)..(7) <223> BCMA humano <400> 1018 Met Leu Gln Met Ala Gly Gln 1 5 <210> 1019 <211> 13 <212> PRT <213> humano <220> <221> misc <222> (1)..(13) <223> BCMA humano <400> 1019 Asn Ala Ser Val Thr Asn Ser Val Lys Gly Thr Asn Ala 1 5 10 <210> 1020 <211> 7 <212> PRT <213> mono rhesus <220> <221> misc <222> (1)..(7) <223> BCMA de mono rhesus <400> 1020 Met Leu Gln Met Ala Arg Gln 1 5 <210> 1021 <211> 13 <212> PRT <213> mono rhesus <220> <221> misc <222> (1)..(13) <223> BCMA de mono rhesus <400> 1021 Asn Ala Ser Met Thr Asn Ser Val Lys Gly Met Asn Ala 1 5 10 <210> 1022 <211> 10 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-101 <400> 1022 Gly Phe Thr Phe Ser Asn Tyr Asp Met Ala 1 5 10 <210> 1023 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-101 <400> 1023 Ser Ile Ile Thr Ser Gly Gly Asp Asn Tyr Tyr Arg Asp Ser Val Lys 1 5 10 15 Gly <210> 1024 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-101 <400> 1024 His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr 1 5 10 <210> 1025 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-101 <400> 1025 Lys Ala Ser Gln Ser Val Gly Ile Asn Val Asp 1 5 10 <210> 1026 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-101 <400> 1026 Gly Ala Ser Asn Arg His Thr 1 5 <210> 1027 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-101 <400> 1027 Leu Gln Tyr Gly Ser Ile Pro Phe Thr 1 5 <210> 1028 <211> 121 <212> PRT <213> artificial <220> <223> VH de BCMA-101 <400> 1028 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 35 40 45 Ala Ser Ile Ile Thr Ser Gly Gly Asp Asn Tyr Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Ser Thr Leu Tyr 65 70 75 80 Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 85 90 95 Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 1029 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-101 <400> 1029 Glu Thr Val Met Thr Gln Ser Pro Thr Ser Met Ser Thr Ser Ile Gly 1 5 10 15 Glu Arg Val Thr Leu Asn Cys Lys Ala Ser Gln Ser Val Gly Ile Asn 20 25 30 Val Asp Trp Tyr Gln Gln Thr Pro Gly Gln Ser Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Asn Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 50 55 60 Ser Gly Phe Gly Arg Asp Phe Thr Leu Thr Ile Ser Asn Val Glu Ala 65 70 75 80 Glu Asp Leu Ala Val Tyr Tyr Cys Leu Gln Tyr Gly Ser Ile Pro Phe 85 90 95 Thr Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys 100 105 <210> 1030 <211> 244 <212> PRT <213> artificial <220> <223> BCMA-101 scFv <400> 1030 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 35 40 45 Ala Ser Ile Ile Thr Ser Gly Gly Asp Asn Tyr Tyr Arg Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Ser Thr Leu Tyr 65 70 75 80 Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 85 90 95 Val Arg His Asp Tyr Tyr Asp Gly Ser Tyr Gly Phe Ala Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Thr Val Met Thr Gln Ser 130 135 140 Pro Thr Ser Met Ser Thr Ser Ile Gly Glu Arg Val Thr Leu Asn Cys 145 150 155 160 Lys Ala Ser Gln Ser Val Gly Ile Asn Val Asp Trp Tyr Gln Gln Thr 165 170 175 Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Gly Ala Ser Asn Arg His 180 185 190 Thr Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Phe Gly Arg Asp Phe 195 200 205 Thr Leu Thr Ile Ser Asn Val Glu Ala Glu Asp Leu Ala Val Tyr Tyr 210 215 220 Cys Leu Gln Tyr Gly Ser Ile Pro Phe Thr Phe Gly Ser Gly Thr Lys 225 230 235 240 Leu Glu Leu Lys <210> 1031 <211> 10 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-102 <400> 1031 Gly Tyr Thr Phe Thr Asn His Ile Ile His 1 5 10 <210> 1032 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-102 <400> 1032 Tyr Ile Asn Pro Tyr Asn Asp Asp Thr Glu Tyr Asn Glu Lys Phe Lys 1 5 10 15 Gly <210> 1033 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-102 <400> 1033 Asp Gly Tyr Tyr Arg Asp Met Asp Val Met Asp Tyr 1 5 10 <210> 1034 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-102 <400> 1034 Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 1035 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-102 <400> 1035 Tyr Thr Ser Arg Leu His Ser 1 5 <210> 1036 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-102 <400> 1036 Gln Gln Gly Asn Thr Leu Pro Trp Thr 1 5 <210> 1037 <211> 122 <212> PRT <213> artificial <220> <223> VH de BCMA-102 <400> 1037 Glu Val Gln Leu Val Glu Gln Ser Gly Pro Glu Leu Val Lys Pro Gly 1 5 10 15 Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn 20 25 30 His Ile Ile His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp 35 40 45 Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Asp Thr Glu Tyr Asn Glu Lys 50 55 60 Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Thr Thr Ala 65 70 75 80 Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Asp Gly Tyr Tyr Arg Asp Met Asp Val Met Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 1038 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-102 <400> 1038 Glu Leu Val Met Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Leu Gly 1 5 10 15 Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 35 40 45 Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 65 70 75 80 Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp 85 90 95 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1039 <211> 244 <212> PRT <213> artificial <220> <223> BCMA-102 scFv <400> 1039 Glu Val Gln Leu Val Glu Gln Ser Gly Pro Glu Leu Val Lys Pro Gly 1 5 10 15 Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn 20 25 30 His Ile Ile His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp 35 40 45 Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Asp Thr Glu Tyr Asn Glu Lys 50 55 60 Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Thr Thr Ala 65 70 75 80 Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Asp Gly Tyr Tyr Arg Asp Met Asp Val Met Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Met Thr Gln Thr 130 135 140 Pro Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys 145 150 155 160 Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys 165 170 175 Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His 180 185 190 Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 195 200 205 Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe 210 215 220 Cys Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys 225 230 235 240 Leu Glu Ile Lys <210> 1040 <211> 10 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-103 <400> 1040 Gly Phe Thr Phe Ser Asn Tyr Asp Met Ala 1 5 10 <210> 1041 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-103 <400> 1041 Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser Val Lys 1 5 10 15 Gly <210> 1042 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-103 <400> 1042 Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr 1 5 10 <210> 1043 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-103 <400> 1043 Arg Ala Ser Glu Asp Ile Tyr Asn Gly Leu Ala 1 5 10 <210> 1044 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-103 <400> 1044 Gly Ala Ser Ser Leu Gln Asp 1 5 <210> 1045 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-103 <400> 1045 Gln Gln Ser Tyr Lys Tyr Pro Leu Thr 1 5 <210> 1046 <211> 122 <212> PRT <213> artificial <220> <223> VH de BCMA-103 <400> 1046 Glu Val Gln Leu Val Glu Glu Ser Gly Gly Gly Leu Leu Gln Pro Gly 1 5 10 15 Arg Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn 20 25 30 Tyr Asp Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp 35 40 45 Val Ala Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser 50 55 60 Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu 65 70 75 80 Tyr Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 1047 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-103 <400> 1047 Glu Leu Val Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Leu Gly 1 5 10 15 Glu Thr Val Thr Ile Glu Cys Arg Ala Ser Glu Asp Ile Tyr Asn Gly 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Ser Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Ser Gly Met Gln Pro 65 70 75 80 Glu Asp Glu Ala Asn Tyr Phe Cys Gln Gln Ser Tyr Lys Tyr Pro Leu 85 90 95 Thr Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys 100 105 <210> 1048 <211> 244 <212> PRT <213> artificial <220> <223> BCMA-103 scFv <400> 1048 Glu Val Gln Leu Val Glu Glu Ser Gly Gly Gly Leu Leu Gln Pro Gly 1 5 10 15 Arg Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn 20 25 30 Tyr Asp Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp 35 40 45 Val Ala Ser Ile Ser Thr Arg Gly Asp Ile Thr Ser Tyr Arg Asp Ser 50 55 60 Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu 65 70 75 80 Tyr Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Gln Asp Tyr Tyr Thr Asp Tyr Met Gly Phe Ala Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly Glu Leu Val Met Thr Gln Ser Pro Ala 130 135 140 Ser Leu Ser Ala Ser Leu Gly Glu Thr Val Thr Ile Glu Cys Arg Ala 145 150 155 160 Ser Glu Asp Ile Tyr Asn Gly Leu Ala Trp Tyr Gln Gln Lys Pro Gly 165 170 175 Lys Ser Pro Gln Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Asp Gly 180 185 190 Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Tyr Ser Leu 195 200 205 Lys Ile Ser Gly Met Gln Pro Glu Asp Glu Ala Asn Tyr Phe Cys Gln 210 215 220 Gln Ser Tyr Lys Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu 225 230 235 240 Leu Lys Gly Ser <210> 1049 <211> 10 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-104 <400> 1049 Gly Phe Thr Phe Ser Asn Phe Asp Met Ala 1 5 10 <210> 1050 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-104 <400> 1050 Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Arg Asp Ser Val Lys 1 5 10 15 Gly <210> 1051 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-104 <400> 1051 His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr 1 5 10 <210> 1052 <211> 10 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-104 <400> 1052 Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu 1 5 10 <210> 1053 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-104 <400> 1053 Tyr Thr Ser Asn Leu Gln Ser 1 5 <210> 1054 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-104 <400> 1054 Gln Gln Tyr Asp Ile Ser Ser Tyr Thr 1 5 <210> 1055 <211> 122 <212> PRT <213> artificial <220> <223> VH de BCMA-104 <400> 1055 Glu Val Gln Leu Val Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 1 5 10 15 Arg Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn 20 25 30 Phe Asp Met Ala Trp Val Arg Gln Ala Pro Thr Arg Gly Leu Glu Trp 35 40 45 Val Ala Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Arg Asp Ser 50 55 60 Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu 65 70 75 80 Tyr Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp 100 105 110 Gly Gln Gly Ala Ser Val Thr Val Ser Ser 115 120 <210> 1056 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-104 <400> 1056 Glu Leu Val Met Thr Gln Thr Pro Ser Ser Met Pro Ala Ser Leu Gly 1 5 10 15 Glu Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Ile Lys Pro Leu Ile 35 40 45 Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Asn Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Ile Ser Ser Tyr 85 90 95 Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1057 <211> 244 <212> PRT <213> artificial <220> <223> BCMA-104 scFv <400> 1057 Glu Val Gln Leu Val Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 1 5 10 15 Arg Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn 20 25 30 Phe Asp Met Ala Trp Val Arg Gln Ala Pro Thr Arg Gly Leu Glu Trp 35 40 45 Val Ala Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Arg Asp Ser 50 55 60 Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu 65 70 75 80 Tyr Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp 100 105 110 Gly Gln Gly Ala Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Met Thr Gln Thr 130 135 140 Pro Ser Ser Met Pro Ala Ser Leu Gly Glu Arg Val Thr Ile Ser Cys 145 150 155 160 Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys 165 170 175 Pro Asp Gly Thr Ile Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln 180 185 190 Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 195 200 205 Ser Leu Thr Ile Asn Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr 210 215 220 Cys Gln Gln Tyr Asp Ile Ser Ser Tyr Thr Phe Gly Ala Gly Thr Lys 225 230 235 240 Leu Glu Ile Lys <210> 1058 <211> 10 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-105 <400> 1058 Gly Phe Thr Phe Ser Asn Phe Asp Met Ala 1 5 10 <210> 1059 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-105 <400> 1059 Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Arg Asp Ser Val Lys 1 5 10 15 Gly <210> 1060 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-105 <400> 1060 His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr 1 5 10 <210> 1061 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-105 <400> 1061 Arg Ala Ser Gln Gly Ile Ser Asn His Leu Asn 1 5 10 <210> 1062 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-105 <400> 1062 Tyr Thr Ser Asn Leu Gln Ser 1 5 <210> 1063 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-105 <400> 1063 Gln Gln Tyr Asp Ser Phe Pro Leu Thr 1 5 <210> 1064 <211> 122 <212> PRT <213> artificial <220> <223> VH de BCMA-105 <400> 1064 Glu Val Gln Leu Val Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 1 5 10 15 Arg Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn 20 25 30 Phe Asp Met Ala Trp Val Arg Gln Ala Pro Thr Arg Gly Leu Glu Trp 35 40 45 Val Ala Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Arg Asp Ser 50 55 60 Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu 65 70 75 80 Tyr Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 1065 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-105 <400> 1065 Glu Leu Val Met Thr Gln Thr Pro Ser Ser Met Pro Ala Ser Leu Gly 1 5 10 15 Glu Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Gly Ile Ser Asn His 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Ile Lys Pro Leu Ile 35 40 45 Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln Tyr Asp Ser Phe Pro Leu 85 90 95 Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1066 <211> 244 <212> PRT <213> artificial <220> <223> BCMA-105 scFv <400> 1066 Glu Val Gln Leu Val Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 1 5 10 15 Arg Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn 20 25 30 Phe Asp Met Ala Trp Val Arg Gln Ala Pro Thr Arg Gly Leu Glu Trp 35 40 45 Val Ala Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Arg Asp Ser 50 55 60 Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu 65 70 75 80 Tyr Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Met Thr Gln Thr 130 135 140 Pro Ser Ser Met Pro Ala Ser Leu Gly Glu Arg Val Thr Ile Ser Cys 145 150 155 160 Arg Ala Ser Gln Gly Ile Ser Asn His Leu Asn Trp Tyr Gln Gln Lys 165 170 175 Pro Asp Gly Thr Ile Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln 180 185 190 Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 195 200 205 Ser Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Met Tyr Tyr 210 215 220 Cys Gln Gln Tyr Asp Ser Phe Pro Leu Thr Phe Gly Ser Gly Thr Lys 225 230 235 240 Leu Glu Ile Lys <210> 1067 <211> 10 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-106 <400> 1067 Gly Phe Thr Phe Ser Asn Phe Asp Met Ala 1 5 10 <210> 1068 <211> 17 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-106 <400> 1068 Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Arg Asp Ser Val Lys 1 5 10 15 Gly <210> 1069 <211> 12 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-106 <400> 1069 His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr 1 5 10 <210> 1070 <211> 11 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-106 <400> 1070 Arg Ala Ser Gln Gly Ile Ser Asn Asn Leu Asn 1 5 10 <210> 1071 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-106 <400> 1071 Tyr Thr Ser Asn Leu Gln Ser 1 5 <210> 1072 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-106 <400> 1072 Gln Gln Phe Asp Thr Ser Pro Tyr Thr 1 5 <210> 1073 <211> 122 <212> PRT <213> artificial <220> <223> VH de BCMA-106 <400> 1073 Glu Val Gln Leu Val Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 1 5 10 15 Arg Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn 20 25 30 Phe Asp Met Ala Trp Val Arg Gln Ala Pro Thr Arg Gly Leu Glu Trp 35 40 45 Val Ala Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Arg Asp Ser 50 55 60 Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu 65 70 75 80 Tyr Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp 100 105 110 Gly Gln Gly Val Met Val Thr Val Ser Ser 115 120 <210> 1074 <211> 107 <212> PRT <213> artificial <220> <223> VL de BCMA-106 <400> 1074 Glu Leu Val Met Thr Gln Thr Pro Ser Ser Met Pro Ala Ser Leu Gly 1 5 10 15 Glu Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Gly Ile Ser Asn Asn 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Ile Lys Pro Leu Ile 35 40 45 Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln Phe Asp Thr Ser Pro Tyr 85 90 95 Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1075 <211> 244 <212> PRT <213> artificial <220> <223> BCMA-106 scFv <400> 1075 Glu Val Gln Leu Val Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 1 5 10 15 Arg Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn 20 25 30 Phe Asp Met Ala Trp Val Arg Gln Ala Pro Thr Arg Gly Leu Glu Trp 35 40 45 Val Ala Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Arg Asp Ser 50 55 60 Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu 65 70 75 80 Tyr Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp 100 105 110 Gly Gln Gly Val Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Met Thr Gln Thr 130 135 140 Pro Ser Ser Met Pro Ala Ser Leu Gly Glu Arg Val Thr Ile Ser Cys 145 150 155 160 Arg Ala Ser Gln Gly Ile Ser Asn Asn Leu Asn Trp Tyr Gln Gln Lys 165 170 175 Pro Asp Gly Thr Ile Lys Pro Leu Ile Tyr Tyr Thr Ser Asn Leu Gln 180 185 190 Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 195 200 205 Ser Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Met Tyr Tyr 210 215 220 Cys Gln Gln Phe Asp Thr Ser Pro Tyr Thr Phe Gly Ala Gly Thr Lys 225 230 235 240 Leu Glu Ile Lys <210> 1076 <211> 10 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-107 <400> 1076 Gly Tyr Ser Phe Pro Asp Tyr Tyr Ile Asn 1 5 10 <210> 1077 <211> 13 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-107 <400> 1077 Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Glu 1 5 10 <210> 1078 <211> 10 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-107 <400> 1078 Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val 1 5 10 <210> 1079 <211> 16 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-107 <400> 1079 Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 1 5 10 15 <210> 1080 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-107 <400> 1080 Lys Val Ser Asn Arg Phe Ser 1 5 <210> 1081 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-107 <400> 1081 Ser Gln Ser Thr His Val Pro Tyr Thr 1 5 <210> 1082 <211> 120 <212> PRT <213> artificial <220> <223> VH de BCMA-107 <400> 1082 Glu Val Gln Leu Val Glu Gln Ser Gly Pro Glu Leu Val Lys Pro Gly 1 5 10 15 Ala Ser Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Ser Phe Pro Asp 20 25 30 Tyr Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp 35 40 45 Ile Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Glu Arg 50 55 60 Phe Thr Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Asn Thr Ala 65 70 75 80 Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe 85 90 95 Cys Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln 100 105 110 Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 1083 <211> 112 <212> PRT <213> artificial <220> <223> VL de BCMA-107 <400> 1083 Glu Leu Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 1 5 10 15 Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 20 25 30 Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 85 90 95 Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 1084 <211> 247 <212> PRT <213> artificial <220> <223> BCMA-107 scFv <400> 1084 Glu Val Gln Leu Val Glu Gln Ser Gly Pro Glu Leu Val Lys Pro Gly 1 5 10 15 Ala Ser Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Ser Phe Pro Asp 20 25 30 Tyr Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp 35 40 45 Ile Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Glu Arg 50 55 60 Phe Thr Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Asn Thr Ala 65 70 75 80 Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe 85 90 95 Cys Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln 100 105 110 Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Met Thr Gln Thr Pro Leu 130 135 140 Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser 145 150 155 160 Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr 165 170 175 Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser 180 185 190 Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 195 200 205 Ala Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly 210 215 220 Val Tyr Phe Cys Ser Gln Ser Thr His Val Pro Tyr Thr Phe Gly Gly 225 230 235 240 Gly Thr Lys Leu Glu Ile Lys 245 <210> 1085 <211> 10 <212> PRT <213> artificial <220> <223> VH CDR1 de BCMA-108 <400> 1085 Gly Tyr Ser Phe Pro Asp Tyr Tyr Ile Asn 1 5 10 <210> 1086 <211> 13 <212> PRT <213> artificial <220> <223> VH CDR2 de BCMA-108 <400> 1086 Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Glu 1 5 10 <210> 1087 <211> 10 <212> PRT <213> artificial <220> <223> VH CDR3 de BCMA-108 <400> 1087 Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val 1 5 10 <210> 1088 <211> 16 <212> PRT <213> artificial <220> <223> VL CDR1 de BCMA-108 <400> 1088 Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 1 5 10 15 <210> 1089 <211> 7 <212> PRT <213> artificial <220> <223> VL CDR2 de BCMA-108 <400> 1089 Lys Val Ser Asn Arg Phe Ser 1 5 <210> 1090 <211> 9 <212> PRT <213> artificial <220> <223> VL CDR3 de BCMA-108 <400> 1090 Phe Gln Gly Ser His Val Pro Trp Thr 1 5 <210> 1091 <211> 120 <212> PRT <213> artificial <220> <223> VH de BCMA-108 <400> 1091 Glu Val Gln Leu Val Glu Gln Ser Gly Pro Gln Leu Val Lys Pro Gly 1 5 10 15 Ala Ser Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Ser Phe Pro Asp 20 25 30 Tyr Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp 35 40 45 Ile Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Glu Arg 50 55 60 Phe Thr Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Asn Thr Ala 65 70 75 80 Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe 85 90 95 Cys Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln 100 105 110 Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 1092 <211> 112 <212> PRT <213> artificial <220> <223> VL de BCMA-108 <400> 1092 Glu Leu Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 1 5 10 15 Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 20 25 30 Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Gly Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Asn Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 85 90 95 Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 1093 <211> 247 <212> PRT <213> artificial <220> <223> BCMA-108 scFv <400> 1093 Glu Val Gln Leu Val Glu Gln Ser Gly Pro Gln Leu Val Lys Pro Gly 1 5 10 15 Ala Ser Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Ser Phe Pro Asp 20 25 30 Tyr Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp 35 40 45 Ile Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Glu Arg 50 55 60 Phe Thr Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Asn Thr Ala 65 70 75 80 Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe 85 90 95 Cys Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln 100 105 110 Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Met Thr Gln Thr Pro Leu 130 135 140 Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser 145 150 155 160 Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr 165 170 175 Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser 180 185 190 Asn Arg Phe Ser Gly Val Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly 195 200 205 Thr Asp Phe Thr Leu Lys Ile Asn Arg Val Glu Ala Glu Asp Leu Gly 210 215 220 Val Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Trp Thr Phe Gly Gly 225 230 235 240 Gly Thr Lys Leu Glu Ile Lys 245