SEQUENCE LISTING <110> HANSA MEDICAL AB <120> CYSTEINE PROTEASE <130> N404881WO <160> 55 <170> PatentIn version 3.5 <210> 1 <211> 339 <212> PRT <213> Streptococcus pyogenes <400> 1 Met Arg Lys Arg Cys Tyr Ser Thr Ser Ala Ala Val Leu Ala Ala Val 1 5 10 15 Thr Leu Phe Val Leu Ser Val Asp Arg Gly Val Ile Ala Asp Ser Phe 20 25 30 Ser Ala Asn Gln Glu Ile Arg Tyr Ser Glu Val Thr Pro Tyr His Val 35 40 45 Thr Ser Val Trp Thr Lys Gly Val Thr Pro Pro Ala Asn Phe Thr Gln 50 55 60 Gly Glu Asp Val Phe His Ala Pro Tyr Val Ala Asn Gln Gly Trp Tyr 65 70 75 80 Asp Ile Thr Lys Thr Phe Asn Gly Lys Asp Asp Leu Leu Cys Gly Ala 85 90 95 Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe Asp Gln Asn Lys Asp 100 105 110 Gln Ile Lys Arg Tyr Leu Glu Glu His Pro Glu Lys Gln Lys Ile Asn 115 120 125 Phe Asn Gly Glu Gln Met Phe Asp Val Lys Glu Ala Ile Asp Thr Lys 130 135 140 Asn His Gln Leu Asp Ser Lys Leu Phe Glu Tyr Phe Lys Glu Lys Ala 145 150 155 160 Phe Pro Tyr Leu Ser Thr Lys His Leu Gly Val Phe Pro Asp His Val 165 170 175 Ile Asp Met Phe Ile Asn Gly Tyr Arg Leu Ser Leu Thr Asn His Gly 180 185 190 Pro Thr Pro Val Lys Glu Gly Ser Lys Asp Pro Arg Gly Gly Ile Phe 195 200 205 Asp Ala Val Phe Thr Arg Gly Asp Gln Ser Lys Leu Leu Thr Ser Arg 210 215 220 His Asp Phe Lys Glu Lys Asn Leu Lys Glu Ile Ser Asp Leu Ile Lys 225 230 235 240 Lys Glu Leu Thr Glu Gly Lys Ala Leu Gly Leu Ser His Thr Tyr Ala 245 250 255 Asn Val Arg Ile Asn His Val Ile Asn Leu Trp Gly Ala Asp Phe Asp 260 265 270 Ser Asn Gly Asn Leu Lys Ala Ile Tyr Val Thr Asp Ser Asp Ser Asn 275 280 285 Ala Ser Ile Gly Met Lys Lys Tyr Phe Val Gly Val Asn Ser Ala Gly 290 295 300 Lys Val Ala Ile Ser Ala Lys Glu Ile Lys Glu Asp Asn Ile Gly Ala 305 310 315 320 Gln Val Leu Gly Leu Phe Thr Leu Ser Thr Gly Gln Asp Ser Trp Asn 325 330 335 Gln Thr Asn <210> 2 <211> 310 <212> PRT <213> Streptococcus pyogenes <400> 2 Asp Ser Phe Ser Ala Asn Gln Glu Ile Arg Tyr Ser Glu Val Thr Pro 1 5 10 15 Tyr His Val Thr Ser Val Trp Thr Lys Gly Val Thr Pro Pro Ala Asn 20 25 30 Phe Thr Gln Gly Glu Asp Val Phe His Ala Pro Tyr Val Ala Asn Gln 35 40 45 Gly Trp Tyr Asp Ile Thr Lys Thr Phe Asn Gly Lys Asp Asp Leu Leu 50 55 60 Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe Asp Gln 65 70 75 80 Asn Lys Asp Gln Ile Lys Arg Tyr Leu Glu Glu His Pro Glu Lys Gln 85 90 95 Lys Ile Asn Phe Asn Gly Glu Gln Met Phe Asp Val Lys Glu Ala Ile 100 105 110 Asp Thr Lys Asn His Gln Leu Asp Ser Lys Leu Phe Glu Tyr Phe Lys 115 120 125 Glu Lys Ala Phe Pro Tyr Leu Ser Thr Lys His Leu Gly Val Phe Pro 130 135 140 Asp His Val Ile Asp Met Phe Ile Asn Gly Tyr Arg Leu Ser Leu Thr 145 150 155 160 Asn His Gly Pro Thr Pro Val Lys Glu Gly Ser Lys Asp Pro Arg Gly 165 170 175 Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp Gln Ser Lys Leu Leu 180 185 190 Thr Ser Arg His Asp Phe Lys Glu Lys Asn Leu Lys Glu Ile Ser Asp 195 200 205 Leu Ile Lys Lys Glu Leu Thr Glu Gly Lys Ala Leu Gly Leu Ser His 210 215 220 Thr Tyr Ala Asn Val Arg Ile Asn His Val Ile Asn Leu Trp Gly Ala 225 230 235 240 Asp Phe Asp Ser Asn Gly Asn Leu Lys Ala Ile Tyr Val Thr Asp Ser 245 250 255 Asp Ser Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe Val Gly Val Asn 260 265 270 Ser Ala Gly Lys Val Ala Ile Ser Ala Lys Glu Ile Lys Glu Asp Asn 275 280 285 Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu Ser Thr Gly Gln Asp 290 295 300 Ser Trp Asn Gln Thr Asn 305 310 <210> 3 <211> 349 <212> PRT <213> Streptococcus pyogenes <400> 3 Met Lys Thr Ile Ala Tyr Pro Asn Lys Pro His Ser Leu Ser Ala Gly 1 5 10 15 Leu Leu Thr Ala Ile Ala Ile Phe Ser Leu Ala Ser Ser Asn Ile Thr 20 25 30 Tyr Ala Asp Asp Tyr Gln Arg Asn Ala Thr Glu Ala Tyr Ala Lys Glu 35 40 45 Val Pro His Gln Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Leu 50 55 60 Thr Pro Glu Gln Phe Arg Tyr Asn Asn Glu Asp Val Ile His Ala Pro 65 70 75 80 Tyr Leu Ala His Gln Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly 85 90 95 Lys Asp Asn Leu Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His 100 105 110 Trp Trp Phe Asp Gln Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys 115 120 125 His Pro Glu Lys Gln Lys Ile Ile Phe Asn Asn Gln Glu Leu Phe Asp 130 135 140 Leu Lys Ala Ala Ile Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu 145 150 155 160 Phe Asn Tyr Phe Arg Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln 165 170 175 Leu Gly Val Met Pro Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr 180 185 190 Tyr Leu Asn Val Phe Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr 195 200 205 Gln Asp Lys Asp Lys Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg 210 215 220 Gly Asp Gln Thr Thr Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys 225 230 235 240 Gly Leu Asn Asp Ile Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly 245 250 255 Arg Ala Leu Ala Leu Ser His Thr Tyr Ala Asn Val Ser Ile Ser His 260 265 270 Val Ile Asn Leu Trp Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu 275 280 285 Ala Ile Tyr Val Thr Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys 290 295 300 Lys Tyr Phe Val Gly Ile Asn Ala His Gly His Val Ala Ile Ser Ala 305 310 315 320 Lys Lys Ile Glu Gly Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe 325 330 335 Thr Leu Ser Ser Gly Lys Asp Ile Trp Gln Lys Leu Ser 340 345 <210> 4 <211> 315 <212> PRT <213> Streptococcus pyogenes <400> 4 Asp Asp Tyr Gln Arg Asn Ala Thr Glu Ala Tyr Ala Lys Glu Val Pro 1 5 10 15 His Gln Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Leu Thr Pro 20 25 30 Glu Gln Phe Arg Tyr Asn Asn Glu Asp Val Ile His Ala Pro Tyr Leu 35 40 45 Ala His Gln Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly Lys Asp 50 55 60 Asn Leu Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp 65 70 75 80 Phe Asp Gln Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His Pro 85 90 95 Glu Lys Gln Lys Ile Ile Phe Asn Asn Gln Glu Leu Phe Asp Leu Lys 100 105 110 Ala Ala Ile Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe Asn 115 120 125 Tyr Phe Arg Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu Gly 130 135 140 Val Met Pro Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr Leu 145 150 155 160 Asn Val Phe Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln Asp 165 170 175 Lys Asp Lys Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp 180 185 190 Gln Thr Thr Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly Leu 195 200 205 Asn Asp Ile Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg Ala 210 215 220 Leu Ala Leu Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val Ile 225 230 235 240 Asn Leu Trp Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile 245 250 255 Tyr Val Thr Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys Tyr 260 265 270 Phe Val Gly Ile Asn Ala His Gly His Val Ala Ile Ser Ala Lys Lys 275 280 285 Ile Glu Gly Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu 290 295 300 Ser Ser Gly Lys Asp Ile Trp Gln Lys Leu Ser 305 310 315 <210> 5 <211> 313 <212> PRT <213> Streptococcus pyogenes <400> 5 Asp Asp Tyr Gln Arg Asn Ala Thr Glu Ala Tyr Ala Lys Glu Val Pro 1 5 10 15 His Gln Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Leu Thr Pro 20 25 30 Glu Gln Phe Arg Tyr Asn Asn Glu Asp Val Phe His Ala Pro Tyr Val 35 40 45 Ala Asn Gln Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly Lys Asp 50 55 60 Asn Leu Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp 65 70 75 80 Phe Asp Gln Asn Lys Asp Gln Ile Lys Arg Tyr Leu Glu Glu His Pro 85 90 95 Glu Lys Gln Lys Ile Asn Phe Asn Gly Asp Asn Met Phe Asp Val Lys 100 105 110 Lys Ala Ile Asp Thr Lys Asn His Gln Leu Asp Ser Lys Leu Phe Asn 115 120 125 Tyr Phe Lys Glu Lys Ala Phe Pro Gly Leu Ser Ala Arg Arg Ile Gly 130 135 140 Val Phe Pro Asp His Val Ile Asp Met Phe Ile Asn Gly Tyr Arg Leu 145 150 155 160 Ser Leu Thr Asn His Gly Pro Thr Pro Val Lys Glu Gly Ser Lys Asp 165 170 175 Pro Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asn Gln Ser 180 185 190 Lys Leu Leu Thr Ser Arg His Asp Phe Lys Asn Lys Asn Leu Asn Asp 195 200 205 Ile Ser Thr Ile Ile Lys Gln Glu Leu Thr Lys Gly Lys Ala Leu Gly 210 215 220 Leu Ser His Thr Tyr Ala Asn Val Ser Ile Asn His Val Ile Asn Leu 225 230 235 240 Trp Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile Tyr Val 245 250 255 Thr Asp Ser Asp Ser Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe Val 260 265 270 Gly Val Asn Ala His Gly His Val Ala Ile Ser Ala Lys Lys Ile Glu 275 280 285 Gly Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu Ser Thr 290 295 300 Gly Gln Asp Ser Trp Gln Lys Leu Ser 305 310 <210> 6 <211> 315 <212> PRT <213> Streptococcus pyogenes <400> 6 Asp Asp Tyr Gln Arg Asn Ala Thr Glu Ala Tyr Ala Lys Glu Val Pro 1 5 10 15 His Gln Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Leu Thr Pro 20 25 30 Glu Gln Phe Arg Tyr Asn Asn Glu Asp Val Ile His Ala Pro Tyr Leu 35 40 45 Ala Asn Gln Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly Lys Asp 50 55 60 Asn Leu Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp 65 70 75 80 Phe Asp Gln Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His Pro 85 90 95 Glu Lys Gln Lys Ile Ile Phe Arg Asn Gln Glu Leu Phe Asp Leu Lys 100 105 110 Glu Ala Ile Arg Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe Glu 115 120 125 Tyr Phe Arg Asp Lys Ala Phe Pro Tyr Leu Ser Ala Arg Gln Leu Gly 130 135 140 Val Met Pro Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr Leu 145 150 155 160 Asn Val Phe Lys Thr Gln Ser Thr Asp Val Lys Arg Pro Tyr Gln Asp 165 170 175 Lys Asp Lys Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asn 180 185 190 Gln Thr Thr Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly Leu 195 200 205 Asn Asp Ile Ser Thr Ile Ile Lys Glu Glu Leu Thr Lys Gly Arg Ala 210 215 220 Leu Ala Leu Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val Ile 225 230 235 240 Asn Leu Trp Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile 245 250 255 Tyr Val Thr Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys Tyr 260 265 270 Phe Val Gly Ile Asn Lys His Gly His Val Ala Ile Ser Ala Lys Lys 275 280 285 Ile Glu Gly Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu 290 295 300 Ser Ser Gly Lys Asp Ile Trp Gln Lys Leu Asn 305 310 315 <210> 7 <211> 315 <212> PRT <213> Streptococcus pyogenes <400> 7 Asp Asp Tyr Gln Arg Asn Ala Thr Glu Ala Tyr Ala Lys Glu Val Pro 1 5 10 15 His Gln Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Leu Thr Pro 20 25 30 Glu Gln Phe Arg Tyr Asn Asn Glu Asp Val Ile His Ala Pro Tyr Leu 35 40 45 Ala His Gln Gly Trp Tyr Asp Ile Thr Lys Thr Phe Asn Gly Lys Asp 50 55 60 Asn Leu Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp 65 70 75 80 Phe Asp Gln Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His Pro 85 90 95 Glu Lys Gln Lys Ile Ile Phe Asn Asn Glu Glu Leu Phe Asp Leu Lys 100 105 110 Ala Ala Ile Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe Asn 115 120 125 Tyr Phe Lys Glu Lys Ala Phe Pro Asn Leu Ser Thr Arg Gln Leu Gly 130 135 140 Val Met Pro Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr Leu 145 150 155 160 Asn Val Phe Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln Asp 165 170 175 Lys Asp Lys Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asn 180 185 190 Gln Thr Thr Leu Leu Thr Ala Arg His Asp Phe Lys Glu Lys Gly Leu 195 200 205 Lys Asp Ile Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg Ala 210 215 220 Leu Ala Leu Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val Ile 225 230 235 240 Asn Leu Trp Gly Ala Asp Phe Asp Ala Glu Gly Asn Leu Lys Ala Ile 245 250 255 Tyr Val Thr Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys Tyr 260 265 270 Phe Val Gly Ile Asn Ala His Gly Lys Val Ala Ile Ser Ala Lys Lys 275 280 285 Ile Glu Gly Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu 290 295 300 Ser Ser Gly Lys Asp Ile Trp Gln Gln Leu Ser 305 310 315 <210> 8 <211> 315 <212> PRT <213> Streptococcus pyogenes <400> 8 Asp Ser Phe Ser Ala Asn Gln Glu Ile Arg Tyr Ser Glu Val Thr Pro 1 5 10 15 Tyr His Val Thr Ser Val Trp Thr Lys Gly Val Thr Pro Leu Thr Pro 20 25 30 Glu Gln Phe Arg Tyr Asn Asn Glu Asp Val Ile His Ala Pro Tyr Leu 35 40 45 Ala His Gln Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly Lys Asp 50 55 60 Asn Leu Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp 65 70 75 80 Phe Asp Gln Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His Pro 85 90 95 Glu Lys Gln Lys Ile Ile Phe Asn Asn Gln Glu Leu Phe Asp Leu Lys 100 105 110 Ala Ala Ile Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe Asn 115 120 125 Tyr Phe Arg Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu Gly 130 135 140 Val Met Pro Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr Leu 145 150 155 160 Asn Val Phe Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln Asp 165 170 175 Lys Asp Lys Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp 180 185 190 Gln Thr Thr Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly Leu 195 200 205 Asn Asp Ile Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg Ala 210 215 220 Leu Ala Leu Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val Ile 225 230 235 240 Asn Leu Trp Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile 245 250 255 Tyr Val Thr Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys Tyr 260 265 270 Phe Val Gly Ile Asn Ala His Gly His Val Ala Ile Ser Ala Lys Lys 275 280 285 Ile Glu Gly Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu 290 295 300 Ser Ser Gly Lys Asp Ile Trp Gln Lys Leu Ser 305 310 315 <210> 9 <211> 295 <212> PRT <213> Streptococcus pyogenes <400> 9 Ser Val Trp Thr Lys Gly Val Thr Pro Leu Thr Pro Glu Gln Phe Arg 1 5 10 15 Tyr Asn Asn Glu Asp Val Ile His Ala Pro Tyr Leu Ala His Gln Gly 20 25 30 Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly Lys Asp Asn Leu Leu Cys 35 40 45 Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe Asp Gln Asn 50 55 60 Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His Pro Glu Lys Gln Lys 65 70 75 80 Ile Ile Phe Asn Asn Gln Glu Leu Phe Asp Leu Lys Ala Ala Ile Asp 85 90 95 Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe Asn Tyr Phe Arg Asp 100 105 110 Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu Gly Val Met Pro Asp 115 120 125 Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr Leu Asn Val Phe Lys 130 135 140 Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln Asp Lys Asp Lys Arg 145 150 155 160 Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp Gln Thr Thr Leu 165 170 175 Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly Leu Asn Asp Ile Ser 180 185 190 Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg Ala Leu Ala Leu Ser 195 200 205 His Thr Tyr Ala Asn Val Ser Ile Ser His Val Ile Asn Leu Trp Gly 210 215 220 Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile Tyr Val Thr Asp 225 230 235 240 Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe Val Gly Ile 245 250 255 Asn Ala His Gly His Val Ala Ile Ser Ala Lys Lys Ile Glu Gly Glu 260 265 270 Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu Ser Ser Gly Lys 275 280 285 Asp Ile Trp Gln Lys Leu Ser 290 295 <210> 10 <211> 314 <212> PRT <213> Streptococcus pyogenes <400> 10 Asp Asp Tyr Gln Arg Asn Ala Thr Glu Ala Tyr Ala Lys Glu Val Pro 1 5 10 15 His Gln Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Leu Thr Pro 20 25 30 Glu Gln Phe Thr Gln Gly Glu Asp Val Ile His Ala Pro Tyr Leu Ala 35 40 45 His Gln Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly Lys Asp Asn 50 55 60 Leu Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe 65 70 75 80 Asp Gln Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His Pro Glu 85 90 95 Lys Gln Lys Ile Ile Phe Asn Asn Gln Glu Leu Phe Asp Leu Lys Ala 100 105 110 Ala Ile Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe Asn Tyr 115 120 125 Phe Arg Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu Gly Val 130 135 140 Met Pro Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr Leu Asn 145 150 155 160 Val Phe Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln Asp Lys 165 170 175 Asp Lys Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp Gln 180 185 190 Thr Thr Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly Leu Asn 195 200 205 Asp Ile Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg Ala Leu 210 215 220 Ala Leu Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val Ile Asn 225 230 235 240 Leu Trp Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile Tyr 245 250 255 Val Thr Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe 260 265 270 Val Gly Ile Asn Ala His Gly His Val Ala Ile Ser Ala Lys Lys Ile 275 280 285 Glu Gly Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu Ser 290 295 300 Ser Gly Lys Asp Ile Trp Gln Lys Leu Ser 305 310 <210> 11 <211> 312 <212> PRT <213> Streptococcus pyogenes <400> 11 Asp Asp Tyr Gln Arg Asn Ala Thr Glu Ala Tyr Ala Lys Glu Val Pro 1 5 10 15 His Gln Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Pro Glu Gln 20 25 30 Phe Thr Gln Gly Glu Asp Val Ile His Ala Pro Tyr Leu Ala His Gln 35 40 45 Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly Lys Asp Asn Leu Leu 50 55 60 Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe Asp Gln 65 70 75 80 Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His Pro Glu Lys Gln 85 90 95 Lys Ile Ile Phe Asn Asn Gln Glu Leu Phe Asp Leu Lys Ala Ala Ile 100 105 110 Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe Asn Tyr Phe Arg 115 120 125 Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu Gly Val Met Pro 130 135 140 Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr Leu Asn Val Phe 145 150 155 160 Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln Asp Lys Asp Lys 165 170 175 Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp Gln Thr Thr 180 185 190 Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly Leu Asn Asp Ile 195 200 205 Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg Ala Leu Ala Leu 210 215 220 Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val Ile Asn Leu Trp 225 230 235 240 Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile Tyr Val Thr 245 250 255 Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe Val Gly 260 265 270 Ile Asn Ala His Gly His Val Ala Ile Ser Ala Lys Lys Ile Glu Gly 275 280 285 Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu Ser Ser Gly 290 295 300 Lys Asp Ile Trp Gln Lys Leu Ser 305 310 <210> 12 <211> 313 <212> PRT <213> Streptococcus pyogenes <400> 12 Asp Asp Tyr Gln Arg Asn Ala Thr Glu Ala Tyr Ala Lys Glu Val Pro 1 5 10 15 His Gln Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Pro Glu Gln 20 25 30 Phe Arg Tyr Asn Asn Glu Asp Val Ile His Ala Pro Tyr Leu Ala His 35 40 45 Gln Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly Lys Asp Asn Leu 50 55 60 Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe Asp 65 70 75 80 Gln Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His Pro Glu Lys 85 90 95 Gln Lys Ile Ile Phe Asn Asn Gln Glu Leu Phe Asp Leu Lys Ala Ala 100 105 110 Ile Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe Asn Tyr Phe 115 120 125 Arg Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu Gly Val Met 130 135 140 Pro Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr Leu Asn Val 145 150 155 160 Phe Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln Asp Lys Asp 165 170 175 Lys Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp Gln Thr 180 185 190 Thr Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly Leu Asn Asp 195 200 205 Ile Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg Ala Leu Ala 210 215 220 Leu Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val Ile Asn Leu 225 230 235 240 Trp Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile Tyr Val 245 250 255 Thr Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe Val 260 265 270 Gly Ile Asn Ala His Gly His Val Ala Ile Ser Ala Lys Lys Ile Glu 275 280 285 Gly Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu Ser Ser 290 295 300 Gly Lys Asp Ile Trp Gln Lys Leu Ser 305 310 <210> 13 <211> 312 <212> PRT <213> Streptococcus pyogenes <400> 13 Asp Asp Tyr Gln Arg Asn Ala Thr Glu Ala Tyr Ala Lys Glu Val Pro 1 5 10 15 His Gln Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Pro Glu Gln 20 25 30 Phe Thr Gln Gly Glu Asp Val Ile His Ala Pro Tyr Leu Ala His Gln 35 40 45 Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly Lys Asp Asn Leu Leu 50 55 60 Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe Asp Gln 65 70 75 80 Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His Pro Glu Lys Gln 85 90 95 Lys Ile Ile Ile Asn Asn Gln Glu Leu Phe Asp Leu Lys Ala Ala Ile 100 105 110 Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe Asn Tyr Phe Arg 115 120 125 Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu Gly Val Met Pro 130 135 140 Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr Leu Asn Val Phe 145 150 155 160 Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln Asp Lys Asp Lys 165 170 175 Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp Gln Thr Thr 180 185 190 Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly Leu Asn Asp Ile 195 200 205 Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg Ala Leu Ala Leu 210 215 220 Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val Ile Asn Leu Trp 225 230 235 240 Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile Tyr Val Thr 245 250 255 Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe Val Gly 260 265 270 Ile Asn Ala His Gly His Val Ala Ile Ser Ala Lys Lys Ile Glu Gly 275 280 285 Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu Ser Ser Gly 290 295 300 Lys Asp Ile Trp Gln Lys Leu Ser 305 310 <210> 14 <211> 312 <212> PRT <213> Streptococcus pyogenes <400> 14 Asp Asp Tyr Gln Arg Asn Ala Thr Glu Ala Tyr Ala Lys Glu Val Pro 1 5 10 15 His Gln Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Pro Glu Gln 20 25 30 Phe Thr Gln Gly Glu Asp Val Ile His Ala Pro Tyr Leu Ala His Gln 35 40 45 Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly Lys Asp Asn Leu Leu 50 55 60 Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe Asp Gln 65 70 75 80 Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His Pro Glu Lys Gln 85 90 95 Lys Ile Ile Phe Arg Asn Gln Glu Leu Phe Asp Leu Lys Ala Ala Ile 100 105 110 Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe Asn Tyr Phe Arg 115 120 125 Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu Gly Val Met Pro 130 135 140 Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr Leu Asn Val Phe 145 150 155 160 Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln Asp Lys Asp Lys 165 170 175 Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp Gln Thr Thr 180 185 190 Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly Leu Asn Asp Ile 195 200 205 Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg Ala Leu Ala Leu 210 215 220 Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val Ile Asn Leu Trp 225 230 235 240 Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile Tyr Val Thr 245 250 255 Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe Val Gly 260 265 270 Ile Asn Ala His Gly His Val Ala Ile Ser Ala Lys Lys Ile Glu Gly 275 280 285 Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu Ser Ser Gly 290 295 300 Lys Asp Ile Trp Gln Lys Leu Ser 305 310 <210> 15 <211> 312 <212> PRT <213> Streptococcus pyogenes <400> 15 Asp Asp Tyr Gln Arg Asn Ala Thr Glu Ala Tyr Ala Lys Glu Val Pro 1 5 10 15 His Gln Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Pro Glu Gln 20 25 30 Phe Thr Gln Gly Glu Asp Val Ile His Ala Pro Tyr Leu Ala His Gln 35 40 45 Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly Lys Asp Asn Leu Leu 50 55 60 Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe Asp Gln 65 70 75 80 Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His Pro Glu Lys Gln 85 90 95 Lys Ile Ile Ile Arg Asn Gln Glu Leu Phe Asp Leu Lys Ala Ala Ile 100 105 110 Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe Asn Tyr Phe Arg 115 120 125 Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu Gly Val Met Pro 130 135 140 Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr Leu Asn Val Phe 145 150 155 160 Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln Asp Lys Asp Lys 165 170 175 Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp Gln Thr Thr 180 185 190 Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly Leu Asn Asp Ile 195 200 205 Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg Ala Leu Ala Leu 210 215 220 Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val Ile Asn Leu Trp 225 230 235 240 Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile Tyr Val Thr 245 250 255 Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe Val Gly 260 265 270 Ile Asn Ala His Gly His Val Ala Ile Ser Ala Lys Lys Ile Glu Gly 275 280 285 Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu Ser Ser Gly 290 295 300 Lys Asp Ile Trp Gln Lys Leu Ser 305 310 <210> 16 <211> 312 <212> PRT <213> Streptococcus pyogenes <400> 16 Asp Asp Tyr Gln Arg Asn Ala Thr Glu Ala Tyr Ala Lys Glu Val Pro 1 5 10 15 His Gln Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Pro Glu Gln 20 25 30 Phe Thr Gln Gly Glu Asp Val Ile His Ala Pro Tyr Leu Ala Asn Gln 35 40 45 Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly Lys Asp Asn Leu Leu 50 55 60 Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe Asp Gln 65 70 75 80 Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His Pro Glu Lys Gln 85 90 95 Lys Ile Ile Phe Arg Asn Gln Glu Leu Phe Asp Leu Lys Glu Ala Ile 100 105 110 Arg Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe Glu Tyr Phe Arg 115 120 125 Asp Lys Ala Phe Pro Tyr Leu Ser Ala Arg Gln Leu Gly Val Met Pro 130 135 140 Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr Leu Asn Val Phe 145 150 155 160 Lys Thr Gln Ser Thr Asp Val Lys Arg Pro Tyr Gln Asp Lys Asp Lys 165 170 175 Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asn Gln Thr Thr 180 185 190 Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly Leu Asn Asp Ile 195 200 205 Ser Thr Ile Ile Lys Glu Glu Leu Thr Lys Gly Arg Ala Leu Ala Leu 210 215 220 Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val Ile Asn Leu Trp 225 230 235 240 Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile Tyr Val Thr 245 250 255 Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe Val Gly 260 265 270 Ile Asn Lys His Gly His Val Ala Ile Ser Ala Lys Lys Ile Glu Gly 275 280 285 Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu Ser Ser Gly 290 295 300 Lys Asp Ile Trp Gln Lys Leu Asn 305 310 <210> 17 <211> 292 <212> PRT <213> Streptococcus pyogenes <400> 17 Ser Val Trp Thr Lys Gly Val Thr Pro Pro Glu Gln Phe Thr Gln Gly 1 5 10 15 Glu Asp Val Ile His Ala Pro Tyr Leu Ala His Gln Gly Trp Tyr Asp 20 25 30 Ile Thr Lys Ala Phe Asp Gly Lys Asp Asn Leu Leu Cys Gly Ala Ala 35 40 45 Thr Ala Gly Asn Met Leu His Trp Trp Phe Asp Gln Asn Lys Thr Glu 50 55 60 Ile Glu Ala Tyr Leu Ser Lys His Pro Glu Lys Gln Lys Ile Ile Phe 65 70 75 80 Arg Asn Gln Glu Leu Phe Asp Leu Lys Ala Ala Ile Asp Thr Lys Asp 85 90 95 Ser Gln Thr Asn Ser Gln Leu Phe Asn Tyr Phe Arg Asp Lys Ala Phe 100 105 110 Pro Asn Leu Ser Ala Arg Gln Leu Gly Val Met Pro Asp Leu Val Leu 115 120 125 Asp Met Phe Ile Asn Gly Tyr Tyr Leu Asn Val Phe Lys Thr Gln Ser 130 135 140 Thr Asp Val Asn Arg Pro Tyr Gln Asp Lys Asp Lys Arg Gly Gly Ile 145 150 155 160 Phe Asp Ala Val Phe Thr Arg Gly Asn Gln Thr Thr Leu Leu Thr Ala 165 170 175 Arg His Asp Leu Lys Asn Lys Gly Leu Asn Asp Ile Ser Thr Ile Ile 180 185 190 Lys Gln Glu Leu Thr Glu Gly Arg Ala Leu Ala Leu Ser His Thr Tyr 195 200 205 Ala Asn Val Ser Ile Ser His Val Ile Asn Leu Trp Gly Ala Asp Phe 210 215 220 Asn Ala Glu Gly Asn Leu Glu Ala Ile Tyr Val Thr Asp Ser Asp Ala 225 230 235 240 Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe Val Gly Ile Asn Ala His 245 250 255 Gly His Val Ala Ile Ser Ala Lys Lys Ile Glu Gly Glu Asn Ile Gly 260 265 270 Ala Gln Val Leu Gly Leu Phe Thr Leu Ser Ser Gly Lys Asp Ile Trp 275 280 285 Gln Lys Leu Ser 290 <210> 18 <211> 312 <212> PRT <213> Streptococcus pyogenes <400> 18 Asp Asp Tyr Gln Arg Asn Ala Thr Glu Ala Tyr Ala Lys Glu Val Pro 1 5 10 15 His Gln Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Pro Glu Gln 20 25 30 Phe Thr Gln Gly Glu Asp Val Ile His Ala Pro Tyr Leu Ala His Gln 35 40 45 Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly Ala Asp Asn Leu Leu 50 55 60 Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe Asp Gln 65 70 75 80 Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His Pro Glu Lys Gln 85 90 95 Lys Ile Ile Phe Arg Asn Gln Glu Leu Phe Asp Leu Lys Ala Ala Ile 100 105 110 Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe Asn Tyr Phe Arg 115 120 125 Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu Gly Val Met Pro 130 135 140 Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr Leu Asn Val Phe 145 150 155 160 Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln Asp Lys Asp Lys 165 170 175 Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asn Gln Thr Thr 180 185 190 Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly Leu Asn Asp Ile 195 200 205 Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg Ala Leu Ala Leu 210 215 220 Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val Ile Asn Leu Trp 225 230 235 240 Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile Tyr Val Thr 245 250 255 Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe Val Gly 260 265 270 Ile Asn Ala His Gly His Val Ala Ile Ser Ala Lys Lys Ile Glu Gly 275 280 285 Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu Ser Ser Gly 290 295 300 Lys Asp Ile Trp Gln Lys Leu Ser 305 310 <210> 19 <211> 292 <212> PRT <213> Streptococcus pyogenes <400> 19 Ser Val Trp Thr Lys Gly Val Thr Pro Pro Glu Gln Phe Thr Gln Gly 1 5 10 15 Glu Asp Val Ile His Ala Pro Tyr Leu Ala His Gln Gly Trp Tyr Asp 20 25 30 Ile Thr Lys Ala Phe Asp Gly Ala Asp Asn Leu Leu Cys Gly Ala Ala 35 40 45 Thr Ala Gly Asn Met Leu His Trp Trp Phe Asp Gln Asn Lys Thr Glu 50 55 60 Ile Glu Ala Tyr Leu Ser Lys His Pro Glu Lys Gln Lys Ile Ile Phe 65 70 75 80 Arg Asn Gln Glu Leu Phe Asp Leu Lys Ala Ala Ile Asp Thr Lys Asp 85 90 95 Ser Gln Thr Asn Ser Gln Leu Phe Asn Tyr Phe Arg Asp Lys Ala Phe 100 105 110 Pro Asn Leu Ser Ala Arg Gln Leu Gly Val Met Pro Asp Leu Val Leu 115 120 125 Asp Met Phe Ile Asn Gly Tyr Tyr Leu Asn Val Phe Lys Thr Gln Ser 130 135 140 Thr Asp Val Asn Arg Pro Tyr Gln Asp Lys Asp Lys Arg Gly Gly Ile 145 150 155 160 Phe Asp Ala Val Phe Thr Arg Gly Asn Gln Thr Thr Leu Leu Thr Ala 165 170 175 Arg His Asp Leu Lys Asn Lys Gly Leu Asn Asp Ile Ser Thr Ile Ile 180 185 190 Lys Gln Glu Leu Thr Glu Gly Arg Ala Leu Ala Leu Ser His Thr Tyr 195 200 205 Ala Asn Val Ser Ile Ser His Val Ile Asn Leu Trp Gly Ala Asp Phe 210 215 220 Asn Ala Glu Gly Asn Leu Glu Ala Ile Tyr Val Thr Asp Ser Asp Ala 225 230 235 240 Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe Val Gly Ile Asn Ala His 245 250 255 Gly His Val Ala Ile Ser Ala Lys Lys Ile Glu Gly Glu Asn Ile Gly 260 265 270 Ala Gln Val Leu Gly Leu Phe Thr Leu Ser Ser Gly Lys Asp Ile Trp 275 280 285 Gln Lys Leu Ser 290 <210> 20 <211> 312 <212> PRT <213> Streptococcus pyogenes <400> 20 Asp Asp Tyr Gln Arg Asn Ala Thr Glu Ala Tyr Ala Lys Glu Val Pro 1 5 10 15 His Gln Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Pro Glu Gln 20 25 30 Phe Thr Gln Gly Glu Asp Val Ile His Ala Pro Tyr Leu Ala His Gln 35 40 45 Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly Lys Asp Asn Leu Leu 50 55 60 Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe Asp Gln 65 70 75 80 Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His Pro Glu Lys Gln 85 90 95 Lys Ile Ile Phe Arg Asn Gln Glu Leu Phe Asp Leu Lys Ala Ala Ile 100 105 110 Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe Asn Tyr Phe Arg 115 120 125 Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu Gly Val Met Pro 130 135 140 Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr Leu Asn Val Phe 145 150 155 160 Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln Asp Lys Asp Lys 165 170 175 Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asn Gln Thr Thr 180 185 190 Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly Leu Asn Asp Ile 195 200 205 Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg Ala Leu Ala Leu 210 215 220 Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val Ile Asn Leu Trp 225 230 235 240 Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile Tyr Val Thr 245 250 255 Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe Val Gly 260 265 270 Ile Asn Ala His Gly His Val Ala Ile Ser Ala Lys Lys Ile Glu Gly 275 280 285 Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu Ser Ser Gly 290 295 300 Lys Asp Ile Trp Gln Lys Leu Ser 305 310 <210> 21 <211> 312 <212> PRT <213> Streptococcus pyogenes <400> 21 Asp Asp Tyr Gln Arg Asn Ala Thr Glu Ala Tyr Ala Lys Glu Val Pro 1 5 10 15 His Gln Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Leu Thr Pro 20 25 30 Glu Gln Phe Thr Gln Gly Glu Asp Val Phe His Ala Pro Tyr Val Ala 35 40 45 Asn Gln Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly Lys Asp Asn 50 55 60 Leu Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe 65 70 75 80 Asp Gln Asn Lys Asp Gln Ile Lys Arg Tyr Leu Glu Glu His Pro Glu 85 90 95 Lys Gln Lys Ile Asn Phe Asn Gly Glu Asn Met Phe Asp Val Lys Lys 100 105 110 Ala Ile Asp Thr Lys Asn His Gln Leu Asp Ser Lys Leu Phe Asn Tyr 115 120 125 Phe Lys Glu Lys Ala Phe Pro Tyr Leu Ser Ala Lys His Leu Gly Val 130 135 140 Phe Pro Asp His Val Ile Asp Met Phe Ile Asn Gly Tyr Arg Leu Ser 145 150 155 160 Leu Thr Asn His Gly Pro Thr Pro Val Lys Glu Gly Ser Lys Asp Pro 165 170 175 Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asn Gln Ser Lys 180 185 190 Leu Leu Thr Ser Arg His Asp Phe Lys Asn Lys Asn Leu Asn Asp Ile 195 200 205 Ser Thr Ile Ile Lys Gln Glu Leu Thr Lys Gly Lys Ala Leu Gly Leu 210 215 220 Ser His Thr Tyr Ala Asn Val Arg Ile Asn His Val Ile Asn Leu Trp 225 230 235 240 Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile Tyr Val Thr 245 250 255 Asp Ser Asp Ser Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe Val Gly 260 265 270 Val Asn Ala His Gly His Val Ala Ile Ser Ala Lys Lys Ile Glu Gly 275 280 285 Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu Ser Thr Gly 290 295 300 Gln Asp Ser Trp Gln Lys Leu Ser 305 310 <210> 22 <211> 312 <212> PRT <213> Streptococcus pyogenes <400> 22 Asp Asp Tyr Gln Arg Asn Ala Thr Glu Ala Tyr Ala Lys Glu Val Pro 1 5 10 15 His Gln Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Leu Thr Pro 20 25 30 Glu Gln Phe Thr Gln Gly Glu Asp Val Phe His Ala Pro Tyr Val Ala 35 40 45 Asn Gln Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly Lys Asp Asn 50 55 60 Leu Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe 65 70 75 80 Asp Gln Asn Lys Asp Gln Ile Lys Arg Tyr Leu Glu Glu His Pro Glu 85 90 95 Lys Gln Lys Ile Asn Phe Arg Gly Glu Asn Met Phe Asp Val Lys Glu 100 105 110 Ala Ile Arg Thr Lys Asn His Gln Leu Asp Ser Lys Leu Phe Glu Tyr 115 120 125 Phe Lys Glu Lys Ala Phe Pro Tyr Leu Ser Ala Lys His Leu Gly Val 130 135 140 Phe Pro Asp His Val Ile Asp Met Phe Ile Asn Gly Tyr Arg Leu Ser 145 150 155 160 Leu Thr Asn His Gly Pro Thr Pro Val Lys Lys Gly Ser Lys Asp Pro 165 170 175 Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asn Gln Ser Lys 180 185 190 Leu Leu Thr Ser Arg His Asp Phe Lys Asn Lys Asn Leu Asn Asp Ile 195 200 205 Ser Thr Ile Ile Lys Ser Glu Leu Thr Asn Gly Lys Ala Leu Gly Leu 210 215 220 Ser His Thr Tyr Ala Asn Val Arg Ile Asn His Val Ile Asn Leu Trp 225 230 235 240 Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile Tyr Val Thr 245 250 255 Asp Ser Asp Ser Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe Val Gly 260 265 270 Val Asn Lys His Gly His Val Ala Ile Ser Ala Lys Lys Ile Glu Gly 275 280 285 Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu Ser Thr Gly 290 295 300 Gln Asp Ser Trp Gln Lys Leu Asn 305 310 <210> 23 <211> 312 <212> PRT <213> Streptococcus pyogenes <400> 23 Asp Asp Tyr Gln Arg Asn Ala Thr Glu Ala Tyr Ala Lys Glu Val Pro 1 5 10 15 His Gln Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Leu Thr Pro 20 25 30 Glu Gln Phe Thr Gln Gly Glu Asp Val Phe His Ala Pro Tyr Val Ala 35 40 45 Asn Gln Gly Trp Tyr Asp Ile Thr Lys Thr Phe Asn Gly Lys Asp Asp 50 55 60 Leu Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe 65 70 75 80 Asp Gln Asn Lys Asp Gln Ile Lys Arg Tyr Leu Glu Glu His Pro Glu 85 90 95 Lys Gln Lys Ile Asn Phe Asn Gly Glu Gln Met Phe Asp Val Lys Glu 100 105 110 Ala Ile Asp Thr Lys Asn His Gln Leu Asp Ser Lys Leu Phe Glu Tyr 115 120 125 Phe Lys Glu Lys Ala Phe Pro Tyr Leu Ser Thr Lys His Leu Gly Val 130 135 140 Phe Pro Asp His Val Ile Asp Met Phe Ile Asn Gly Tyr Arg Leu Ser 145 150 155 160 Leu Thr Asn His Gly Pro Thr Pro Val Lys Glu Gly Ser Lys Asp Pro 165 170 175 Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asn Gln Ser Lys 180 185 190 Leu Leu Thr Ser Arg His Asp Phe Lys Glu Lys Asn Leu Lys Glu Ile 195 200 205 Ser Asp Leu Ile Lys Gln Glu Leu Thr Glu Gly Lys Ala Leu Gly Leu 210 215 220 Ser His Thr Tyr Ala Asn Val Arg Ile Asn His Val Ile Asn Leu Trp 225 230 235 240 Gly Ala Asp Phe Asp Ala Glu Gly Asn Leu Lys Ala Ile Tyr Val Thr 245 250 255 Asp Ser Asp Ser Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe Val Gly 260 265 270 Val Asn Ala Ala Gly Lys Val Ala Ile Ser Ala Lys Lys Ile Glu Gly 275 280 285 Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu Ser Thr Gly 290 295 300 Gln Asp Ser Trp Asn Gln Thr Ser 305 310 <210> 24 <211> 312 <212> PRT <213> Streptococcus pyogenes <400> 24 Asp Asp Tyr Gln Arg Asn Ala Thr Glu Ala Tyr Ala Lys Glu Val Pro 1 5 10 15 His Gln Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Leu Thr Pro 20 25 30 Glu Gln Phe Thr Gln Gly Glu Asp Val Phe His Ala Pro Tyr Val Ala 35 40 45 Asn Gln Gly Trp Tyr Asp Ile Thr Lys Thr Phe Asn Gly Lys Asp Asp 50 55 60 Leu Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe 65 70 75 80 Asp Gln Asn Lys Asp Gln Ile Lys Arg Tyr Leu Glu Glu His Pro Glu 85 90 95 Lys Gln Lys Ile Asn Phe Arg Gly Glu Gln Met Phe Asp Val Lys Glu 100 105 110 Ala Ile Arg Thr Lys Asn His Gln Leu Asp Ser Lys Leu Phe Glu Tyr 115 120 125 Phe Lys Glu Lys Ala Phe Pro Tyr Leu Ser Thr Lys His Leu Gly Val 130 135 140 Phe Pro Asp His Val Ile Asp Met Phe Ile Asn Gly Tyr Arg Leu Ser 145 150 155 160 Leu Thr Asn His Gly Pro Thr Pro Val Lys Lys Gly Ser Lys Asp Pro 165 170 175 Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asn Gln Ser Lys 180 185 190 Leu Leu Thr Ser Arg His Asp Phe Lys Glu Lys Asn Leu Lys Glu Ile 195 200 205 Ser Asp Leu Ile Lys Glu Glu Leu Thr Lys Gly Lys Ala Leu Gly Leu 210 215 220 Ser His Thr Tyr Ala Asn Val Arg Ile Asn His Val Ile Asn Leu Trp 225 230 235 240 Gly Ala Asp Phe Asp Ala Glu Gly Asn Leu Lys Ala Ile Tyr Val Thr 245 250 255 Asp Ser Asp Ser Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe Val Gly 260 265 270 Val Asn Lys Ala Gly Lys Val Ala Ile Ser Ala Lys Lys Ile Glu Gly 275 280 285 Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu Ser Thr Gly 290 295 300 Gln Asp Ser Trp Asn Gln Thr Asn 305 310 <210> 25 <211> 310 <212> PRT <213> Streptococcus pyogenes <400> 25 Asp Asp Tyr Gln Arg Asn Ala Thr Glu Ala Tyr Ala Lys Glu Val Pro 1 5 10 15 His Gln Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Pro Glu Gln 20 25 30 Phe Thr Gln Gly Glu Asp Val Ile His Ala Pro Tyr Val Ala Asn Gln 35 40 45 Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly Lys Asp Asn Leu Leu 50 55 60 Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe Asp Gln 65 70 75 80 Asn Lys Asp Gln Ile Lys Arg Tyr Leu Glu Glu His Pro Glu Lys Gln 85 90 95 Lys Ile Asn Phe Arg Gly Glu Gln Met Phe Asp Val Lys Lys Ala Ile 100 105 110 Asp Thr Lys Asn His Gln Leu Asp Ser Lys Leu Phe Asn Tyr Phe Lys 115 120 125 Glu Lys Ala Phe Pro Gly Leu Ser Ala Arg Arg Ile Gly Val Phe Pro 130 135 140 Asp His Val Ile Asp Met Phe Ile Asn Gly Tyr Arg Leu Ser Leu Thr 145 150 155 160 Asn His Gly Pro Thr Pro Val Lys Glu Gly Ser Lys Asp Pro Arg Gly 165 170 175 Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asn Gln Ser Lys Leu Leu 180 185 190 Thr Ser Arg His Asp Phe Lys Asn Lys Asn Leu Asn Asp Ile Ser Thr 195 200 205 Ile Ile Lys Gln Glu Leu Thr Lys Gly Lys Ala Leu Gly Leu Ser His 210 215 220 Thr Tyr Ala Asn Val Ser Ile Asn His Val Ile Asn Leu Trp Gly Ala 225 230 235 240 Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile Tyr Val Thr Asp Ser 245 250 255 Asp Ser Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe Val Gly Val Asn 260 265 270 Ala His Gly His Val Ala Ile Ser Ala Lys Lys Ile Glu Gly Glu Asn 275 280 285 Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu Ser Thr Gly Gln Asp 290 295 300 Ser Trp Gln Lys Leu Ser 305 310 <210> 26 <211> 320 <212> PRT <213> Streptococcus pyogenes <400> 26 Met Asp Ser Phe Ser Ala Asn Gln Glu Ile Arg Tyr Ser Glu Val Thr 1 5 10 15 Pro Tyr His Val Thr Ser Val Trp Thr Lys Gly Val Thr Pro Pro Ala 20 25 30 Asn Phe Thr Gln Gly Glu Asp Val Phe His Ala Pro Tyr Val Ala Asn 35 40 45 Gln Gly Trp Tyr Asp Ile Thr Lys Thr Phe Asn Gly Lys Asp Asp Leu 50 55 60 Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe Asp 65 70 75 80 Gln Asn Lys Asp Gln Ile Lys Arg Tyr Leu Glu Glu His Pro Glu Lys 85 90 95 Gln Lys Ile Asn Phe Asn Gly Glu Gln Met Phe Asp Val Lys Glu Ala 100 105 110 Ile Asp Thr Lys Asn His Gln Leu Asp Ser Lys Leu Phe Glu Tyr Phe 115 120 125 Lys Glu Lys Ala Phe Pro Tyr Leu Ser Thr Lys His Leu Gly Val Phe 130 135 140 Pro Asp His Val Ile Asp Met Phe Ile Asn Gly Tyr Arg Leu Ser Leu 145 150 155 160 Thr Asn His Gly Pro Thr Pro Val Lys Glu Gly Ser Lys Asp Pro Arg 165 170 175 Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp Gln Ser Lys Leu 180 185 190 Leu Thr Ser Arg His Asp Phe Lys Glu Lys Asn Leu Lys Glu Ile Ser 195 200 205 Asp Leu Ile Lys Lys Glu Leu Thr Glu Gly Lys Ala Leu Gly Leu Ser 210 215 220 His Thr Tyr Ala Asn Val Arg Ile Asn His Val Ile Asn Leu Trp Gly 225 230 235 240 Ala Asp Phe Asp Ser Asn Gly Asn Leu Lys Ala Ile Tyr Val Thr Asp 245 250 255 Ser Asp Ser Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe Val Gly Val 260 265 270 Asn Ser Ala Gly Lys Val Ala Ile Ser Ala Lys Glu Ile Lys Glu Asp 275 280 285 Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu Ser Thr Gly Gln 290 295 300 Asp Ser Trp Asn Gln Thr Asn Gly Gly Gly His His His His His His 305 310 315 320 <210> 27 <211> 325 <212> PRT <213> Streptococcus pyogenes <400> 27 Met Asp Asp Tyr Gln Arg Asn Ala Thr Glu Ala Tyr Ala Lys Glu Val 1 5 10 15 Pro His Gln Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Leu Thr 20 25 30 Pro Glu Gln Phe Arg Tyr Asn Asn Glu Asp Val Ile His Ala Pro Tyr 35 40 45 Leu Ala His Gln Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly Lys 50 55 60 Asp Asn Leu Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp 65 70 75 80 Trp Phe Asp Gln Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His 85 90 95 Pro Glu Lys Gln Lys Ile Ile Phe Asn Asn Gln Glu Leu Phe Asp Leu 100 105 110 Lys Ala Ala Ile Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe 115 120 125 Asn Tyr Phe Arg Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu 130 135 140 Gly Val Met Pro Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr 145 150 155 160 Leu Asn Val Phe Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln 165 170 175 Asp Lys Asp Lys Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly 180 185 190 Asp Gln Thr Thr Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly 195 200 205 Leu Asn Asp Ile Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg 210 215 220 Ala Leu Ala Leu Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val 225 230 235 240 Ile Asn Leu Trp Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala 245 250 255 Ile Tyr Val Thr Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys 260 265 270 Tyr Phe Val Gly Ile Asn Ala His Gly His Val Ala Ile Ser Ala Lys 275 280 285 Lys Ile Glu Gly Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr 290 295 300 Leu Ser Ser Gly Lys Asp Ile Trp Gln Lys Leu Ser Gly Gly Gly His 305 310 315 320 His His His His His 325 <210> 28 <211> 323 <212> PRT <213> Streptococcus pyogenes <400> 28 Met Asp Asp Tyr Gln Arg Asn Ala Thr Glu Ala Tyr Ala Lys Glu Val 1 5 10 15 Pro His Gln Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Leu Thr 20 25 30 Pro Glu Gln Phe Arg Tyr Asn Asn Glu Asp Val Phe His Ala Pro Tyr 35 40 45 Val Ala Asn Gln Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly Lys 50 55 60 Asp Asn Leu Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp 65 70 75 80 Trp Phe Asp Gln Asn Lys Asp Gln Ile Lys Arg Tyr Leu Glu Glu His 85 90 95 Pro Glu Lys Gln Lys Ile Asn Phe Asn Gly Asp Asn Met Phe Asp Val 100 105 110 Lys Lys Ala Ile Asp Thr Lys Asn His Gln Leu Asp Ser Lys Leu Phe 115 120 125 Asn Tyr Phe Lys Glu Lys Ala Phe Pro Gly Leu Ser Ala Arg Arg Ile 130 135 140 Gly Val Phe Pro Asp His Val Ile Asp Met Phe Ile Asn Gly Tyr Arg 145 150 155 160 Leu Ser Leu Thr Asn His Gly Pro Thr Pro Val Lys Glu Gly Ser Lys 165 170 175 Asp Pro Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asn Gln 180 185 190 Ser Lys Leu Leu Thr Ser Arg His Asp Phe Lys Asn Lys Asn Leu Asn 195 200 205 Asp Ile Ser Thr Ile Ile Lys Gln Glu Leu Thr Lys Gly Lys Ala Leu 210 215 220 Gly Leu Ser His Thr Tyr Ala Asn Val Ser Ile Asn His Val Ile Asn 225 230 235 240 Leu Trp Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile Tyr 245 250 255 Val Thr Asp Ser Asp Ser Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe 260 265 270 Val Gly Val Asn Ala His Gly His Val Ala Ile Ser Ala Lys Lys Ile 275 280 285 Glu Gly Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu Ser 290 295 300 Thr Gly Gln Asp Ser Trp Gln Lys Leu Ser Gly Gly Gly His His His 305 310 315 320 His His His <210> 29 <211> 11 <212> PRT <213> Streptococcus pyogenes <400> 29 Pro Leu Thr Pro Glu Gln Phe Arg Tyr Asn Asn 1 5 10 <210> 30 <211> 8 <212> PRT <213> Streptococcus pyogenes <400> 30 Pro Pro Ala Asn Phe Thr Gln Gly 1 5 <210> 31 <211> 20 <212> PRT <213> Streptococcus pyogenes <400> 31 Asp Asp Tyr Gln Arg Asn Ala Thr Glu Ala Tyr Ala Lys Glu Val Pro 1 5 10 15 His Gln Ile Thr 20 <210> 32 <211> 20 <212> PRT <213> Streptococcus pyogenes <400> 32 Asp Ser Phe Ser Ala Asn Gln Glu Ile Arg Tyr Ser Glu Val Thr Pro 1 5 10 15 Tyr His Val Thr 20 <210> 33 <211> 963 <212> DNA <213> Streptococcus pyogenes <400> 33 atggatagtt tttctgctaa tcaagagatt agatattcgg aagtaacacc ttatcacgtt 60 acttccgttt ggaccaaagg agttactcct ccagcaaact tcactcaagg tgaagatgtt 120 tttcacgctc cttatgttgc taaccaagga tggtatgata ttaccaaaac attcaatgga 180 aaagacgatc ttctttgcgg ggctgccaca gcagggaata tgcttcactg gtggttcgat 240 caaaacaaag accaaattaa acgttatttg gaagagcatc cagaaaagca aaaaataaac 300 ttcaatggcg aacagatgtt tgacgtaaaa gaagctatcg acactaaaaa ccaccagcta 360 gatagtaaat tatttgaata ttttaaagaa aaagctttcc cttatctatc tactaaacac 420 ctaggagttt tccctgatca tgtaattgat atgttcatta acggctaccg ccttagtcta 480 actaaccacg gtccaacgcc agtaaaagaa ggtagtaaag atccccgagg tggtattttt 540 gacgccgtat ttacaagagg tgatcaaagt aagctattga caagtcgtca tgattttaaa 600 gaaaaaaatc tcaaagaaat cagtgatctc attaagaaag agttaaccga aggcaaggct 660 ctaggcctat cacacaccta cgctaacgta cgcatcaacc atgttataaa cctgtgggga 720 gctgactttg attctaacgg gaaccttaaa gctatttatg taacagactc tgatagtaat 780 gcatctattg gtatgaagaa atactttgtt ggtgttaatt ccgctggaaa agtagctatt 840 tctgctaaag aaataaaaga agataatata ggtgctcaag tactagggtt atttacactt 900 tcaacagggc aagatagttg gaatcagacc aatggcggtg gccatcatca ccatcaccac 960 taa 963 <210> 34 <211> 978 <212> DNA <213> Streptococcus pyogenes <400> 34 atggacgatt accaaaggaa tgctacggaa gcttatgcca aagaagtacc acatcagatc 60 acttctgtat ggaccaaagg tgttacacca ctaacacccg agcagtttcg atataataac 120 gaagatgtga tccatgcgcc atatcttgct catcaaggct ggtacgatat caccaaggcc 180 ttcgatggga aggataatct cttgtgtggc gcagcaacgg caggtaatat gctgcattgg 240 tggtttgatc aaaataaaac agagattgaa gcctatttaa gtaaacaccc tgaaaagcaa 300 aaaatcattt ttaacaacca agagctattt gatttgaaag ctgctatcga taccaaggac 360 agtcaaacca atagtcagct ttttaattat tttagagata aagcctttcc aaatctatca 420 gcacgtcaac tcggggttat gcctgatctt gttctagata tgtttatcaa tggttactac 480 ttaaatgtgt ttaaaacaca gtctactgat gtcaatcgac cttatcagga caaggacaaa 540 cgaggtggta ttttcgatgc tgttttcacc agaggagatc agacaacgct cttgacagct 600 cgtcatgatt taaaaaataa aggactaaat gacatcagca ccattatcaa gcaagaactg 660 actgaaggaa gagcccttgc tttatcacat acctacgcca atgttagcat tagccatgtg 720 attaacttgt ggggagctga ttttaatgct gaaggaaacc ttgaggccat ctatgtcaca 780 gactcagatg ctaatgcgtc tattggtatg aaaaaatatt ttgtcggcat taatgctcat 840 ggacatgtcg ccatttctgc caagaaaata gaaggagaaa acattggcgc tcaagtatta 900 ggcttattta cgctttccag tggcaaggac atttggcaga aactgagcgg cggtggccat 960 catcaccatc accactaa 978 <210> 35 <211> 972 <212> DNA <213> Streptococcus pyogenes <400> 35 atggatgatt atcagcgcaa cgcgaccgaa gcgtatgcga aagaagtgcc gcatcagatt 60 accagcgtgt ggaccaaagg cgtgaccccg ctgaccccgg aacagtttcg ctataacaac 120 gaagatgtgt ttcatgcgcc gtatgtggcg aaccagggct ggtatgatat taccaaagcg 180 tttgatggca aagataacct gctgtgcggc gcggcgaccg cgggcaacat gctgcattgg 240 tggtttgatc agaacaaaga tcagattaaa cgctatctgg aagaacatcc ggaaaaacag 300 aaaattaact ttaacggcga taacatgttt gatgtgaaaa aagcgattga taccaaaaac 360 catcagctgg atagcaaact gtttaactat tttaaagaaa aagcgtttcc gggcctgagc 420 gcgcgccgca ttggcgtgtt tccggatcat gtgattgata tgtttattaa cggctatcgc 480 ctgagcctga ccaaccatgg cccgaccccg gtgaaagaag gcagcaaaga tccgcgcggc 540 ggcatttttg atgcggtgtt tacccgcggc aaccagagca aactgctgac cagccgccat 600 gattttaaaa acaaaaacct gaacgatatt agcaccatta ttaaacagga actgaccaaa 660 ggcaaagcgc tgggcctgag ccatacctat gcgaacgtga gcattaacca tgtgattaac 720 ctgtggggcg cggattttaa cgcggaaggc aacctggaag cgatttatgt gaccgatagc 780 gatagcaacg cgagcattgg catgaaaaaa tattttgtgg gcgtgaacgc gcatggccat 840 gtggcgatta gcgcgaaaaa aattgaaggc gaaaacattg gcgcgcaggt gctgggcctg 900 tttaccctga gcaccggcca ggatagctgg cagaaactga gcggcggtgg ccatcatcac 960 catcaccact aa 972 <210> 36 <211> 978 <212> DNA <213> Streptococcus pyogenes <400> 36 atggatgatt atcagcgcaa cgcgaccgaa gcgtatgcga aagaagtgcc gcatcagatt 60 accagcgtgt ggaccaaagg cgtgaccccg ctgaccccgg aacagtttcg ctataacaac 120 gaagatgtga ttcatgcgcc gtatctggcg aaccagggct ggtatgatat taccaaagcg 180 tttgatggca aagataacct gctgtgcggc gcggcgaccg cgggcaacat gctgcattgg 240 tggtttgatc agaacaaaac cgaaattgaa gcgtatctga gcaaacatcc ggaaaaacag 300 aaaattattt ttcgcaacca ggaactgttt gatctgaaag aagcgattcg caccaaagat 360 agccagacca acagccagct gtttgaatat tttcgcgata aagcgtttcc gtatctgagc 420 gcgcgccagc tgggcgtgat gccggatctg gtgctggata tgtttattaa cggctattat 480 ctgaacgtgt ttaaaaccca gagcaccgat gtgaaacgcc cgtatcagga taaagataaa 540 cgcggcggca tttttgatgc ggtgtttacc cgcggcaacc agaccaccct gctgaccgcg 600 cgccatgatc tgaaaaacaa aggcctgaac gatattagca ccattattaa agaagaactg 660 accaaaggcc gcgcgctggc gctgagccat acctatgcga acgtgagcat tagccatgtg 720 attaacctgt ggggcgcgga ttttaacgcg gaaggcaacc tggaagcgat ttatgtgacc 780 gatagcgatg cgaacgcgag cattggcatg aaaaaatatt ttgtgggcat taacaaacat 840 ggccatgtgg cgattagcgc gaaaaaaatt gaaggcgaaa acattggcgc gcaggtgctg 900 ggcctgttta ccctgagcag cggcaaagat atttggcaga aactgaacgg cggtggccat 960 catcaccatc accactaa 978 <210> 37 <211> 978 <212> DNA <213> Streptococcus pyogenes <400> 37 atggatgatt atcagcgcaa cgcgaccgaa gcgtatgcga aagaagtgcc gcatcagatt 60 accagcgtgt ggaccaaagg cgtgaccccg ctgaccccgg aacagtttcg ctataacaac 120 gaagatgtga ttcatgcgcc gtatctggcg catcagggct ggtatgatat taccaaaacc 180 tttaacggca aagataacct gctgtgcggc gcggcgaccg cgggcaacat gctgcattgg 240 tggtttgatc agaacaaaac cgaaattgaa gcgtatctga gcaaacatcc ggaaaaacag 300 aaaattattt ttaacaacga agaactgttt gatctgaaag cggcgattga taccaaagat 360 agccagacca acagccagct gtttaactat tttaaagaaa aagcgtttcc gaacctgagc 420 acccgccagc tgggcgtgat gccggatctg gtgctggata tgtttattaa cggctattat 480 ctgaacgtgt ttaaaaccca gagcaccgat gtgaaccgcc cgtatcagga taaagataaa 540 cgcggcggca tttttgatgc ggtgtttacc cgcggcaacc agaccaccct gctgaccgcg 600 cgccatgatt ttaaagaaaa aggcctgaaa gatattagca ccattattaa acaggaactg 660 accgaaggcc gcgcgctggc gctgagccat acctatgcga acgtgagcat tagccatgtg 720 attaacctgt ggggcgcgga ttttgatgcg gaaggcaacc tgaaagcgat ttatgtgacc 780 gatagcgatg cgaacgcgag cattggcatg aaaaaatatt ttgtgggcat taacgcgcat 840 ggcaaagtgg cgattagcgc gaaaaaaatt gaaggcgaaa acattggcgc gcaggtgctg 900 ggcctgttta ccctgagcag cggcaaagat atttggcagc agctgagcgg cggtggccat 960 catcaccatc accactaa 978 <210> 38 <211> 978 <212> DNA <213> Streptococcus pyogenes <400> 38 atggatagct ttagcgcgaa ccaggaaatt cgctatagcg aagtgacccc gtatcatgtg 60 accagcgtgt ggaccaaagg cgtgaccccg ctgaccccgg aacagtttcg ctataacaac 120 gaagatgtga ttcatgcgcc gtatctggcg catcagggct ggtatgatat taccaaagcg 180 tttgatggca aagataacct gctgtgcggc gcggcgaccg cgggcaacat gctgcattgg 240 tggtttgatc agaacaaaac cgaaattgaa gcgtatctga gcaaacatcc ggaaaaacag 300 aaaattattt ttaacaacca ggaactgttt gatctgaaag cggcgattga taccaaagat 360 agccagacca acagccagct gtttaactat tttcgcgata aagcgtttcc gaacctgagc 420 gcgcgccagc tgggcgtgat gccggatctg gtgctggata tgtttattaa cggctattat 480 ctgaacgtgt ttaaaaccca gagcaccgat gtgaaccgcc cgtatcagga taaagataaa 540 cgcggcggca tttttgatgc ggtgtttacc cgcggcgatc agaccaccct gctgaccgcg 600 cgccatgatc tgaaaaacaa aggcctgaac gatattagca ccattattaa acaggaactg 660 accgaaggcc gcgcgctggc gctgagccat acctatgcga acgtgagcat tagccatgtg 720 attaacctgt ggggcgcgga ttttaacgcg gaaggcaacc tggaagcgat ttatgtgacc 780 gatagcgatg cgaacgcgag cattggcatg aaaaaatatt ttgtgggcat taacgcgcat 840 ggccatgtgg cgattagcgc gaaaaaaatt gaaggcgaaa acattggcgc gcaggtgctg 900 ggcctgttta ccctgagcag cggcaaagat atttggcaga aactgagcgg cggtggccat 960 catcaccatc accactaa 978 <210> 39 <211> 918 <212> DNA <213> Streptococcus pyogenes <400> 39 atgagcgtgt ggaccaaagg cgtgaccccg ctgaccccgg aacagtttcg ctataacaac 60 gaagatgtga ttcatgcgcc gtatctggcg catcagggct ggtatgatat taccaaagcg 120 tttgatggca aagataacct gctgtgcggc gcggcgaccg cgggcaacat gctgcattgg 180 tggtttgatc agaacaaaac cgaaattgaa gcgtatctga gcaaacatcc ggaaaaacag 240 aaaattattt ttaacaacca ggaactgttt gatctgaaag cggcgattga taccaaagat 300 agccagacca acagccagct gtttaactat tttcgcgata aagcgtttcc gaacctgagc 360 gcgcgccagc tgggcgtgat gccggatctg gtgctggata tgtttattaa cggctattat 420 ctgaacgtgt ttaaaaccca gagcaccgat gtgaaccgcc cgtatcagga taaagataaa 480 cgcggcggca tttttgatgc ggtgtttacc cgcggcgatc agaccaccct gctgaccgcg 540 cgccatgatc tgaaaaacaa aggcctgaac gatattagca ccattattaa acaggaactg 600 accgaaggcc gcgcgctggc gctgagccat acctatgcga acgtgagcat tagccatgtg 660 attaacctgt ggggcgcgga ttttaacgcg gaaggcaacc tggaagcgat ttatgtgacc 720 gatagcgatg cgaacgcgag cattggcatg aaaaaatatt ttgtgggcat taacgcgcat 780 ggccatgtgg cgattagcgc gaaaaaaatt gaaggcgaaa acattggcgc gcaggtgctg 840 ggcctgttta ccctgagcag cggcaaagat atttggcaga aactgagcgg cggtggccat 900 catcaccatc accactaa 918 <210> 40 <211> 975 <212> DNA <213> Streptococcus pyogenes <400> 40 atggacgatt accaaaggaa tgctacggaa gcttatgcca aagaagtacc acatcagatc 60 acttctgtat ggaccaaagg tgttacacca ctaacacccg agcagtttac tcaaggtgaa 120 gatgtgatcc atgcgccata tcttgctcat caaggctggt acgatatcac caaggccttc 180 gatgggaagg ataatctctt gtgtggcgca gcaacggcag gtaatatgct gcattggtgg 240 tttgatcaaa ataaaacaga gattgaagcc tatttaagta aacaccctga aaagcaaaaa 300 atcattttta acaaccaaga gctatttgat ttgaaagctg ctatcgatac caaggacagt 360 caaaccaata gtcagctttt taattatttt agagataaag cctttccaaa tctatcagca 420 cgtcaactcg gggttatgcc tgatcttgtt ctagatatgt ttatcaatgg ttactactta 480 aatgtgttta aaacacagtc tactgatgtc aatcgacctt atcaggacaa ggacaaacga 540 ggtggtattt tcgatgctgt tttcaccaga ggagatcaga caacgctctt gacagctcgt 600 catgatttaa aaaataaagg actaaatgac atcagcacca ttatcaagca agaactgact 660 gaaggaagag cccttgcttt atcacatacc tacgccaatg ttagcattag ccatgtgatt 720 aacttgtggg gagctgattt taatgctgaa ggaaaccttg aggccatcta tgtcacagac 780 tcagatgcta atgcgtctat tggtatgaaa aaatattttg tcggcattaa tgctcatgga 840 catgtcgcca tttctgccaa gaaaatagaa ggagaaaaca ttggcgctca agtattaggc 900 ttatttacgc tttccagtgg caaggacatt tggcagaaac tgagcggcgg tggccatcat 960 caccatcacc actaa 975 <210> 41 <211> 969 <212> DNA <213> Streptococcus pyogenes <400> 41 atggacgatt accaaaggaa tgctacggaa gcttatgcca aagaagtacc acatcagatc 60 acttctgtat ggaccaaagg tgttacacca cccgagcagt ttactcaagg tgaagatgtg 120 atccatgcgc catatcttgc tcatcaaggc tggtacgata tcaccaaggc cttcgatggg 180 aaggataatc tcttgtgtgg cgcagcaacg gcaggtaata tgctgcattg gtggtttgat 240 caaaataaaa cagagattga agcctattta agtaaacacc ctgaaaagca aaaaatcatt 300 tttaacaacc aagagctatt tgatttgaaa gctgctatcg ataccaagga cagtcaaacc 360 aatagtcagc tttttaatta ttttagagat aaagcctttc caaatctatc agcacgtcaa 420 ctcggggtta tgcctgatct tgttctagat atgtttatca atggttacta cttaaatgtg 480 tttaaaacac agtctactga tgtcaatcga ccttatcagg acaaggacaa acgaggtggt 540 attttcgatg ctgttttcac cagaggagat cagacaacgc tcttgacagc tcgtcatgat 600 ttaaaaaata aaggactaaa tgacatcagc accattatca agcaagaact gactgaagga 660 agagcccttg ctttatcaca tacctacgcc aatgttagca ttagccatgt gattaacttg 720 tggggagctg attttaatgc tgaaggaaac cttgaggcca tctatgtcac agactcagat 780 gctaatgcgt ctattggtat gaaaaaatat tttgtcggca ttaatgctca tggacatgtc 840 gccatttctg ccaagaaaat agaaggagaa aacattggcg ctcaagtatt aggcttattt 900 acgctttcca gtggcaagga catttggcag aaactgagcg gcggtggcca tcatcaccat 960 caccactaa 969 <210> 42 <211> 972 <212> DNA <213> Streptococcus pyogenes <400> 42 atggacgatt accaaaggaa tgctacggaa gcttatgcca aagaagtacc acatcagatc 60 acttctgtat ggaccaaagg tgttacacca cccgagcagt ttcgatataa taacgaagat 120 gtgatccatg cgccatatct tgctcatcaa ggctggtacg atatcaccaa ggccttcgat 180 gggaaggata atctcttgtg tggcgcagca acggcaggta atatgctgca ttggtggttt 240 gatcaaaata aaacagagat tgaagcctat ttaagtaaac accctgaaaa gcaaaaaatc 300 atttttaaca accaagagct atttgatttg aaagctgcta tcgataccaa ggacagtcaa 360 accaatagtc agctttttaa ttattttaga gataaagcct ttccaaatct atcagcacgt 420 caactcgggg ttatgcctga tcttgttcta gatatgttta tcaatggtta ctacttaaat 480 gtgtttaaaa cacagtctac tgatgtcaat cgaccttatc aggacaagga caaacgaggt 540 ggtattttcg atgctgtttt caccagagga gatcagacaa cgctcttgac agctcgtcat 600 gatttaaaaa ataaaggact aaatgacatc agcaccatta tcaagcaaga actgactgaa 660 ggaagagccc ttgctttatc acatacctac gccaatgtta gcattagcca tgtgattaac 720 ttgtggggag ctgattttaa tgctgaagga aaccttgagg ccatctatgt cacagactca 780 gatgctaatg cgtctattgg tatgaaaaaa tattttgtcg gcattaatgc tcatggacat 840 gtcgccattt ctgccaagaa aatagaagga gaaaacattg gcgctcaagt attaggctta 900 tttacgcttt ccagtggcaa ggacatttgg cagaaactga gcggcggtgg ccatcatcac 960 catcaccact aa 972 <210> 43 <211> 969 <212> DNA <213> Streptococcus pyogenes <400> 43 atggacgatt accaaaggaa tgctacggaa gcttatgcca aagaagtacc acatcagatc 60 acttctgtat ggaccaaagg tgttacacca cccgagcagt ttactcaagg tgaagatgtg 120 atccatgcgc catatcttgc tcatcaaggc tggtacgata tcaccaaggc cttcgatggg 180 aaggataatc tcttgtgtgg cgcagcaacg gcaggtaata tgctgcattg gtggtttgat 240 caaaataaaa cagagattga agcctattta agtaaacacc ctgaaaagca aaaaatcatt 300 attaacaacc aagagctatt tgatttgaaa gctgctatcg ataccaagga cagtcaaacc 360 aatagtcagc tttttaatta ttttagagat aaagcctttc caaatctatc agcacgtcaa 420 ctcggggtta tgcctgatct tgttctagat atgtttatca atggttacta cttaaatgtg 480 tttaaaacac agtctactga tgtcaatcga ccttatcagg acaaggacaa acgaggtggt 540 attttcgatg ctgttttcac cagaggagat cagacaacgc tcttgacagc tcgtcatgat 600 ttaaaaaata aaggactaaa tgacatcagc accattatca agcaagaact gactgaagga 660 agagcccttg ctttatcaca tacctacgcc aatgttagca ttagccatgt gattaacttg 720 tggggagctg attttaatgc tgaaggaaac cttgaggcca tctatgtcac agactcagat 780 gctaatgcgt ctattggtat gaaaaaatat tttgtcggca ttaatgctca tggacatgtc 840 gccatttctg ccaagaaaat agaaggagaa aacattggcg ctcaagtatt aggcttattt 900 acgctttcca gtggcaagga catttggcag aaactgagcg gcggtggcca tcatcaccat 960 caccactaa 969 <210> 44 <211> 969 <212> DNA <213> Streptococcus pyogenes <400> 44 atggacgatt accaaaggaa tgctacggaa gcttatgcca aagaagtacc acatcagatc 60 acttctgtat ggaccaaagg tgttacacca cccgagcagt ttactcaagg tgaagatgtg 120 atccatgcgc catatcttgc tcatcaaggc tggtacgata tcaccaaggc cttcgatggg 180 aaggataatc tcttgtgtgg cgcagcaacg gcaggtaata tgctgcattg gtggtttgat 240 caaaataaaa cagagattga agcctattta agtaaacacc ctgaaaagca aaaaatcatt 300 tttcgtaacc aagagctatt tgatttgaaa gctgctatcg ataccaagga cagtcaaacc 360 aatagtcagc tttttaatta ttttagagat aaagcctttc caaatctatc agcacgtcaa 420 ctcggggtta tgcctgatct tgttctagat atgtttatca atggttacta cttaaatgtg 480 tttaaaacac agtctactga tgtcaatcga ccttatcagg acaaggacaa acgaggtggt 540 attttcgatg ctgttttcac cagaggagat cagacaacgc tcttgacagc tcgtcatgat 600 ttaaaaaata aaggactaaa tgacatcagc accattatca agcaagaact gactgaagga 660 agagcccttg ctttatcaca tacctacgcc aatgttagca ttagccatgt gattaacttg 720 tggggagctg attttaatgc tgaaggaaac cttgaggcca tctatgtcac agactcagat 780 gctaatgcgt ctattggtat gaaaaaatat tttgtcggca ttaatgctca tggacatgtc 840 gccatttctg ccaagaaaat agaaggagaa aacattggcg ctcaagtatt aggcttattt 900 acgctttcca gtggcaagga catttggcag aaactgagcg gcggtggcca tcatcaccat 960 caccactaa 969 <210> 45 <211> 969 <212> DNA <213> Streptococcus pyogenes <400> 45 atggacgatt accaaaggaa tgctacggaa gcttatgcca aagaagtacc acatcagatc 60 acttctgtat ggaccaaagg tgttacacca cccgagcagt ttactcaagg tgaagatgtg 120 atccatgcgc catatcttgc tcatcaaggc tggtacgata tcaccaaggc cttcgatggg 180 aaggataatc tcttgtgtgg cgcagcaacg gcaggtaata tgctgcattg gtggtttgat 240 caaaataaaa cagagattga agcctattta agtaaacacc ctgaaaagca aaaaatcatt 300 attcgtaacc aagagctatt tgatttgaaa gctgctatcg ataccaagga cagtcaaacc 360 aatagtcagc tttttaatta ttttagagat aaagcctttc caaatctatc agcacgtcaa 420 ctcggggtta tgcctgatct tgttctagat atgtttatca atggttacta cttaaatgtg 480 tttaaaacac agtctactga tgtcaatcga ccttatcagg acaaggacaa acgaggtggt 540 attttcgatg ctgttttcac cagaggagat cagacaacgc tcttgacagc tcgtcatgat 600 ttaaaaaata aaggactaaa tgacatcagc accattatca agcaagaact gactgaagga 660 agagcccttg ctttatcaca tacctacgcc aatgttagca ttagccatgt gattaacttg 720 tggggagctg attttaatgc tgaaggaaac cttgaggcca tctatgtcac agactcagat 780 gctaatgcgt ctattggtat gaaaaaatat tttgtcggca ttaatgctca tggacatgtc 840 gccatttctg ccaagaaaat agaaggagaa aacattggcg ctcaagtatt aggcttattt 900 acgctttcca gtggcaagga catttggcag aaactgagcg gcggtggcca tcatcaccat 960 caccactaa 969 <210> 46 <211> 969 <212> DNA <213> Streptococcus pyogenes <400> 46 atggatgatt atcagcgcaa cgcgaccgaa gcgtatgcga aagaagtgcc gcatcagatt 60 accagcgtgt ggaccaaagg cgtgaccccg ccggaacagt ttactcaagg tgaagatgtg 120 attcatgcgc cgtatctggc gaaccagggc tggtatgata ttaccaaagc gtttgatggc 180 aaagataacc tgctgtgcgg cgcggcgacc gcgggcaaca tgctgcattg gtggtttgat 240 cagaacaaaa ccgaaattga agcgtatctg agcaaacatc cggaaaaaca gaaaattatt 300 tttcgcaacc aggaactgtt tgatctgaaa gaagcgattc gcaccaaaga tagccagacc 360 aacagccagc tgtttgaata ttttcgcgat aaagcgtttc cgtatctgag cgcgcgccag 420 ctgggcgtga tgccggatct ggtgctggat atgtttatta acggctatta tctgaacgtg 480 tttaaaaccc agagcaccga tgtgaaacgc ccgtatcagg ataaagataa acgcggcggc 540 atttttgatg cggtgtttac ccgcggcaac cagaccaccc tgctgaccgc gcgccatgat 600 ctgaaaaaca aaggcctgaa cgatattagc accattatta aagaagaact gaccaaaggc 660 cgcgcgctgg cgctgagcca tacctatgcg aacgtgagca ttagccatgt gattaacctg 720 tggggcgcgg attttaacgc ggaaggcaac ctggaagcga tttatgtgac cgatagcgat 780 gcgaacgcga gcattggcat gaaaaaatat tttgtgggca ttaacaaaca tggccatgtg 840 gcgattagcg cgaaaaaaat tgaaggcgaa aacattggcg cgcaggtgct gggcctgttt 900 accctgagca gcggcaaaga tatttggcag aaactgaacg gcggtggcca tcatcaccat 960 caccactaa 969 <210> 47 <211> 909 <212> DNA <213> Streptococcus pyogenes <400> 47 atgtctgtat ggaccaaagg tgttacacca cccgagcagt ttactcaagg tgaagatgtg 60 atccatgcgc catatcttgc tcatcaaggc tggtacgata tcaccaaggc cttcgatggg 120 aaggataatc tcttgtgtgg cgcagcaacg gcaggtaata tgctgcattg gtggtttgat 180 caaaataaaa cagagattga agcctattta agtaaacacc ctgaaaagca aaaaatcatt 240 tttcgtaacc aagagctatt tgatttgaaa gctgctatcg ataccaagga cagtcaaacc 300 aatagtcagc tttttaatta ttttagagat aaagcctttc caaatctatc agcacgtcaa 360 ctcggggtta tgcctgatct tgttctagat atgtttatca atggttacta cttaaatgtg 420 tttaaaacac agtctactga tgtcaatcga ccttatcagg acaaggacaa acgaggtggt 480 attttcgatg ctgttttcac cagaggaaac cagacaacgc tcttgacagc tcgtcatgat 540 ttaaaaaata aaggactaaa tgacatcagc accattatca agcaagaact gactgaagga 600 agagcccttg ctttatcaca tacctacgcc aatgttagca ttagccatgt gattaacttg 660 tggggagctg attttaatgc tgaaggaaac cttgaggcca tctatgtcac agactcagat 720 gctaatgcgt ctattggtat gaaaaaatat tttgtcggca ttaatgctca tggacatgtc 780 gccatttctg ccaagaaaat agaaggagaa aacattggcg ctcaagtatt aggcttattt 840 acgctttcca gtggcaagga catttggcag aaactgagcg gcggtggcca tcatcaccat 900 caccactaa 909 <210> 48 <211> 969 <212> DNA <213> Streptococcus pyogenes <400> 48 atggacgatt accaaaggaa tgctacggaa gcttatgcca aagaagtacc acatcagatc 60 acttctgtat ggaccaaagg tgttacacca cccgagcagt ttactcaagg tgaagatgtg 120 atccatgcgc catatcttgc tcatcaaggc tggtacgata tcaccaaggc cttcgatggg 180 gcggataatc tcttgtgtgg cgcagcaacg gcaggtaata tgctgcattg gtggtttgat 240 caaaataaaa cagagattga agcctattta agtaaacacc ctgaaaagca aaaaatcatt 300 tttcgtaacc aagagctatt tgatttgaaa gctgctatcg ataccaagga cagtcaaacc 360 aatagtcagc tttttaatta ttttagagat aaagcctttc caaatctatc agcacgtcaa 420 ctcggggtta tgcctgatct tgttctagat atgtttatca atggttacta cttaaatgtg 480 tttaaaacac agtctactga tgtcaatcga ccttatcagg acaaggacaa acgaggtggt 540 attttcgatg ctgttttcac cagaggaaat cagacaacgc tcttgacagc tcgtcatgat 600 ttaaaaaata aaggactaaa tgacatcagc accattatca agcaagaact gactgaagga 660 agagcccttg ctttatcaca tacctacgcc aatgttagca ttagccatgt gattaacttg 720 tggggagctg attttaatgc tgaaggaaac cttgaggcca tctatgtcac agactcagat 780 gctaatgcgt ctattggtat gaaaaaatat tttgtcggca ttaatgctca tggacatgtc 840 gccatttctg ccaagaaaat agaaggagaa aacattggcg ctcaagtatt aggcttattt 900 acgctttcca gtggcaagga catttggcag aaactgagcg gcggtggcca tcatcaccat 960 caccactaa 969 <210> 49 <211> 909 <212> DNA <213> Streptococcus pyogenes <400> 49 atgtctgtat ggaccaaagg tgttacacca cccgagcagt ttactcaagg tgaagatgtg 60 atccatgcgc catatcttgc tcatcaaggc tggtacgata tcaccaaggc cttcgatggg 120 gcggataatc tcttgtgtgg cgcagcaacg gcaggtaata tgctgcattg gtggtttgat 180 caaaataaaa cagagattga agcctattta agtaaacacc ctgaaaagca aaaaatcatt 240 tttcgtaacc aagagctatt tgatttgaaa gctgctatcg ataccaagga cagtcaaacc 300 aatagtcagc tttttaatta ttttagagat aaagcctttc caaatctatc agcacgtcaa 360 ctcggggtta tgcctgatct tgttctagat atgtttatca atggttacta cttaaatgtg 420 tttaaaacac agtctactga tgtcaatcga ccttatcagg acaaggacaa acgaggtggt 480 attttcgatg ctgttttcac cagaggaaat cagacaacgc tcttgacagc tcgtcatgat 540 ttaaaaaata aaggactaaa tgacatcagc accattatca agcaagaact gactgaagga 600 agagcccttg ctttatcaca tacctacgcc aatgttagca ttagccatgt gattaacttg 660 tggggagctg attttaatgc tgaaggaaac cttgaggcca tctatgtcac agactcagat 720 gctaatgcgt ctattggtat gaaaaaatat tttgtcggca ttaatgctca tggacatgtc 780 gccatttctg ccaagaaaat agaaggagaa aacattggcg ctcaagtatt aggcttattt 840 acgctttcca gtggcaagga catttggcag aaactgagcg gcggtggcca tcatcaccat 900 caccactaa 909 <210> 50 <211> 969 <212> DNA <213> Streptococcus pyogenes <400> 50 atggacgatt accaaaggaa tgctacggaa gcttatgcca aagaagtacc acatcagatc 60 acttctgtat ggaccaaagg tgttacacca cccgagcagt ttactcaagg tgaagatgtg 120 atccatgcgc catatcttgc tcatcaaggc tggtacgata tcaccaaggc cttcgatggg 180 aaggataatc tcttgtgtgg cgcagcaacg gcaggtaata tgctgcattg gtggtttgat 240 caaaataaaa cagagattga agcctattta agtaaacacc ctgaaaagca aaaaatcatt 300 tttcgtaacc aagagctatt tgatttgaaa gctgctatcg ataccaagga cagtcaaacc 360 aatagtcagc tttttaatta ttttagagat aaagcctttc caaatctatc agcacgtcaa 420 ctcggggtta tgcctgatct tgttctagat atgtttatca atggttacta cttaaatgtg 480 tttaaaacac agtctactga tgtcaatcga ccttatcagg acaaggacaa acgaggtggt 540 attttcgatg ctgttttcac cagaggaaac cagacaacgc tcttgacagc tcgtcatgat 600 ttaaaaaata aaggactaaa tgacatcagc accattatca agcaagaact gactgaagga 660 agagcccttg ctttatcaca tacctacgcc aatgttagca ttagccatgt gattaacttg 720 tggggagctg attttaatgc tgaaggaaac cttgaggcca tctatgtcac agactcagat 780 gctaatgcgt ctattggtat gaaaaaatat tttgtcggca ttaatgctca tggacatgtc 840 gccatttctg ccaagaaaat agaaggagaa aacattggcg ctcaagtatt aggcttattt 900 acgctttcca gtggcaagga catttggcag aaactgagcg gcggtggcca tcatcaccat 960 caccactaa 969 <210> 51 <211> 969 <212> DNA <213> Streptococcus pyogenes <400> 51 atggatgatt atcagcgcaa cgcgaccgaa gcgtatgcga aagaagtgcc gcatcagatt 60 accagcgtgt ggaccaaagg cgtgaccccg ctgaccccgg aacagtttac ccagggcgaa 120 gatgtgtttc atgcgccgta tgtggcgaac cagggctggt atgatattac caaagcgttt 180 gatggcaaag ataacctgct gtgcggcgcg gcgaccgcgg gcaacatgct gcattggtgg 240 tttgatcaga acaaagatca gattaaacgc tatctggaag aacatccgga aaaacagaaa 300 attaacttta acggcgaaaa catgtttgat gtgaaaaaag cgattgatac caaaaaccat 360 cagctggata gcaaactgtt taactatttt aaagaaaaag cgtttccgta tctgagcgcg 420 aaacatctgg gcgtgtttcc ggatcatgtg attgatatgt ttattaacgg ctatcgcctg 480 agcctgacca accatggccc gaccccggtg aaagaaggca gcaaagatcc gcgcggcggc 540 atttttgatg cggtgtttac ccgcggcaac cagagcaaac tgctgaccag ccgccatgat 600 tttaaaaaca aaaacctgaa cgatattagc accattatta aacaggaact gaccaaaggc 660 aaagcgctgg gcctgagcca tacctatgcg aacgtgcgca ttaaccatgt gattaacctg 720 tggggcgcgg attttaacgc ggaaggcaac ctggaagcga tttatgtgac cgatagcgat 780 agcaacgcga gcattggcat gaaaaaatat tttgtgggcg tgaacgcgca tggccatgtg 840 gcgattagcg cgaaaaaaat tgaaggcgaa aacattggcg cgcaggtgct gggcctgttt 900 accctgagca ccggccagga tagctggcag aaactgagcg gcggtggcca tcatcaccat 960 caccactaa 969 <210> 52 <211> 969 <212> DNA <213> Streptococcus pyogenes <400> 52 atggatgatt atcagcgcaa cgcgaccgaa gcgtatgcga aagaagtgcc gcatcagatt 60 accagcgtgt ggaccaaagg cgtgaccccg ctgaccccgg aacagtttac ccagggcgaa 120 gatgtgtttc atgcgccgta tgtggcgaac cagggctggt atgatattac caaagcgttt 180 gatggcaaag ataacctgct gtgcggcgcg gcgaccgcgg gcaacatgct gcattggtgg 240 tttgatcaga acaaagatca gattaaacgc tatctggaag aacatccgga aaaacagaaa 300 attaactttc gcggcgaaaa catgtttgat gtgaaagaag cgattcgcac caaaaaccat 360 cagctggata gcaaactgtt tgaatatttt aaagaaaaag cgtttccgta tctgagcgcg 420 aaacatctgg gcgtgtttcc ggatcatgtg attgatatgt ttattaacgg ctatcgcctg 480 agcctgacca accatggccc gaccccggtg aaaaaaggca gcaaagatcc gcgcggcggc 540 atttttgatg cggtgtttac ccgcggcaac cagagcaaac tgctgaccag ccgccatgat 600 tttaaaaaca aaaacctgaa cgatattagc accattatta aaagcgaact gaccaacggc 660 aaagcgctgg gcctgagcca tacctatgcg aacgtgcgca ttaaccatgt gattaacctg 720 tggggcgcgg attttaacgc ggaaggcaac ctggaagcga tttatgtgac cgatagcgat 780 agcaacgcga gcattggcat gaaaaaatat tttgtgggcg tgaacaaaca tggccatgtg 840 gcgattagcg cgaaaaaaat tgaaggcgaa aacattggcg cgcaggtgct gggcctgttt 900 accctgagca ccggccagga tagctggcag aaactgaacg gcggtggcca tcatcaccat 960 caccactaa 969 <210> 53 <211> 969 <212> DNA <213> Streptococcus pyogenes <400> 53 atggatgatt atcagcgcaa cgcgaccgaa gcgtatgcga aagaagtgcc gcatcagatt 60 accagcgtgt ggaccaaagg cgtgaccccg ctgaccccgg aacagtttac ccagggcgaa 120 gatgtgtttc atgcgccgta tgtggcgaac cagggctggt atgatattac caaaaccttt 180 aacggcaaag atgatctgct gtgcggcgcg gcgaccgcgg gcaacatgct gcattggtgg 240 tttgatcaga acaaagatca gattaaacgc tatctggaag aacatccgga aaaacagaaa 300 attaacttta acggcgaaca gatgtttgat gtgaaagaag cgattgatac caaaaaccat 360 cagctggata gcaaactgtt tgaatatttt aaagaaaaag cgtttccgta tctgagcacc 420 aaacatctgg gcgtgtttcc ggatcatgtg attgatatgt ttattaacgg ctatcgcctg 480 agcctgacca accatggccc gaccccggtg aaagaaggca gcaaagatcc gcgcggcggc 540 atttttgatg cggtgtttac ccgcggcaac cagagcaaac tgctgaccag ccgccatgat 600 tttaaagaaa aaaacctgaa agaaattagc gatctgatta aacaggaact gaccgaaggc 660 aaagcgctgg gcctgagcca tacctatgcg aacgtgcgca ttaaccatgt gattaacctg 720 tggggcgcgg attttgatgc ggaaggcaac ctgaaagcga tttatgtgac cgatagcgat 780 agcaacgcga gcattggcat gaaaaaatat tttgtgggcg tgaacgcggc gggcaaagtg 840 gcgattagcg cgaaaaaaat tgaaggcgaa aacattggcg cgcaggtgct gggcctgttt 900 accctgagca ccggccagga tagctggaac cagaccagcg gcggtggcca tcatcaccat 960 caccactaa 969 <210> 54 <211> 969 <212> DNA <213> Streptococcus pyogenes <400> 54 atggatgatt atcagcgcaa cgcgaccgaa gcgtatgcga aagaagtgcc gcatcagatt 60 accagcgtgt ggaccaaagg cgtgaccccg ctgaccccgg aacagtttac ccagggcgaa 120 gatgtgtttc atgcgccgta tgtggcgaac cagggctggt atgatattac caaaaccttt 180 aacggcaaag atgatctgct gtgcggcgcg gcgaccgcgg gcaacatgct gcattggtgg 240 tttgatcaga acaaagatca gattaaacgc tatctggaag aacatccgga aaaacagaaa 300 attaactttc gcggcgaaca gatgtttgat gtgaaagaag cgattcgcac caaaaaccat 360 cagctggata gcaaactgtt tgaatatttt aaagaaaaag cgtttccgta tctgagcacc 420 aaacatctgg gcgtgtttcc ggatcatgtg attgatatgt ttattaacgg ctatcgcctg 480 agcctgacca accatggccc gaccccggtg aaaaaaggca gcaaagatcc gcgcggcggc 540 atttttgatg cggtgtttac ccgcggcaac cagagcaaac tgctgaccag ccgccatgat 600 tttaaagaaa aaaacctgaa agaaattagc gatctgatta aagaagaact gaccaaaggc 660 aaagcgctgg gcctgagcca tacctatgcg aacgtgcgca ttaaccatgt gattaacctg 720 tggggcgcgg attttgatgc ggaaggcaac ctgaaagcga tttatgtgac cgatagcgat 780 agcaacgcga gcattggcat gaaaaaatat tttgtgggcg tgaacaaagc gggcaaagtg 840 gcgattagcg cgaaaaaaat tgaaggcgaa aacattggcg cgcaggtgct gggcctgttt 900 accctgagca ccggccagga tagctggaac cagaccaacg gcggtggcca tcatcaccat 960 caccactaa 969 <210> 55 <211> 963 <212> DNA <213> Streptococcus pyogenes <400> 55 atggatgatt atcagcgcaa cgcgaccgaa gcgtatgcga aagaagtgcc gcatcagatt 60 accagcgtgt ggaccaaagg cgtgaccccg ccggaacagt ttactcaagg tgaagatgtg 120 attcatgcgc cgtatgtggc gaaccagggc tggtatgata ttaccaaagc gtttgatggc 180 aaagataacc tgctgtgcgg cgcggcgacc gcgggcaaca tgctgcattg gtggtttgat 240 cagaacaaag atcagattaa acgctatctg gaagaacatc cggaaaaaca gaaaattaac 300 tttcgcggcg aacagatgtt tgatgtgaaa aaagcgattg ataccaaaaa ccatcagctg 360 gatagcaaac tgtttaacta ttttaaagaa aaagcgtttc cgggcctgag cgcgcgccgc 420 attggcgtgt ttccggatca tgtgattgat atgtttatta acggctatcg cctgagcctg 480 accaaccatg gcccgacccc ggtgaaagaa ggcagcaaag atccgcgcgg cggcattttt 540 gatgcggtgt ttacccgcgg caaccagagc aaactgctga ccagccgcca tgattttaaa 600 aacaaaaacc tgaacgatat tagcaccatt attaaacagg aactgaccaa aggcaaagcg 660 ctgggcctga gccataccta tgcgaacgtg agcattaacc atgtgattaa cctgtggggc 720 gcggatttta acgcggaagg caacctggaa gcgatttatg tgaccgatag cgatagcaac 780 gcgagcattg gcatgaaaaa atattttgtg ggcgtgaacg cgcatggcca tgtggcgatt 840 agcgcgaaaa aaattgaagg cgaaaacatt ggcgcgcagg tgctgggcct gtttaccctg 900 agcaccggcc aggatagctg gcagaaactg agcggcggtg gccatcatca ccatcaccac 960 taa 963