SEQUENCE LISTING <110> HANSA MEDICAL AB <120> CYSTEINE PROTEASE <130> N404707WO <160> 37 <170> PatentIn version 3.5 <210> 1 <211> 339 <212> PRT <213> Streptococcus pyogenes <400> 1 Met Arg Lys Arg Cys Tyr Ser Thr Ser Ala Ala Val Leu Ala Ala Val 1 5 10 15 Thr Leu Phe Val Leu Ser Val Asp Arg Gly Val Ile Ala Asp Ser Phe 20 25 30 Ser Ala Asn Gln Glu Ile Arg Tyr Ser Glu Val Thr Pro Tyr His Val 35 40 45 Thr Ser Val Trp Thr Lys Gly Val Thr Pro Pro Ala Asn Phe Thr Gln 50 55 60 Gly Glu Asp Val Phe His Ala Pro Tyr Val Ala Asn Gln Gly Trp Tyr 65 70 75 80 Asp Ile Thr Lys Thr Phe Asn Gly Lys Asp Asp Leu Leu Cys Gly Ala 85 90 95 Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe Asp Gln Asn Lys Asp 100 105 110 Gln Ile Lys Arg Tyr Leu Glu Glu His Pro Glu Lys Gln Lys Ile Asn 115 120 125 Phe Asn Gly Glu Gln Met Phe Asp Val Lys Glu Ala Ile Asp Thr Lys 130 135 140 Asn His Gln Leu Asp Ser Lys Leu Phe Glu Tyr Phe Lys Glu Lys Ala 145 150 155 160 Phe Pro Tyr Leu Ser Thr Lys His Leu Gly Val Phe Pro Asp His Val 165 170 175 Ile Asp Met Phe Ile Asn Gly Tyr Arg Leu Ser Leu Thr Asn His Gly 180 185 190 Pro Thr Pro Val Lys Glu Gly Ser Lys Asp Pro Arg Gly Gly Ile Phe 195 200 205 Asp Ala Val Phe Thr Arg Gly Asp Gln Ser Lys Leu Leu Thr Ser Arg 210 215 220 His Asp Phe Lys Glu Lys Asn Leu Lys Glu Ile Ser Asp Leu Ile Lys 225 230 235 240 Lys Glu Leu Thr Glu Gly Lys Ala Leu Gly Leu Ser His Thr Tyr Ala 245 250 255 Asn Val Arg Ile Asn His Val Ile Asn Leu Trp Gly Ala Asp Phe Asp 260 265 270 Ser Asn Gly Asn Leu Lys Ala Ile Tyr Val Thr Asp Ser Asp Ser Asn 275 280 285 Ala Ser Ile Gly Met Lys Lys Tyr Phe Val Gly Val Asn Ser Ala Gly 290 295 300 Lys Val Ala Ile Ser Ala Lys Glu Ile Lys Glu Asp Asn Ile Gly Ala 305 310 315 320 Gln Val Leu Gly Leu Phe Thr Leu Ser Thr Gly Gln Asp Ser Trp Asn 325 330 335 Gln Thr Asn <210> 2 <211> 310 <212> PRT <213> Streptococcus pyogenes <400> 2 Asp Ser Phe Ser Ala Asn Gln Glu Ile Arg Tyr Ser Glu Val Thr Pro 1 5 10 15 Tyr His Val Thr Ser Val Trp Thr Lys Gly Val Thr Pro Pro Ala Asn 20 25 30 Phe Thr Gln Gly Glu Asp Val Phe His Ala Pro Tyr Val Ala Asn Gln 35 40 45 Gly Trp Tyr Asp Ile Thr Lys Thr Phe Asn Gly Lys Asp Asp Leu Leu 50 55 60 Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe Asp Gln 65 70 75 80 Asn Lys Asp Gln Ile Lys Arg Tyr Leu Glu Glu His Pro Glu Lys Gln 85 90 95 Lys Ile Asn Phe Asn Gly Glu Gln Met Phe Asp Val Lys Glu Ala Ile 100 105 110 Asp Thr Lys Asn His Gln Leu Asp Ser Lys Leu Phe Glu Tyr Phe Lys 115 120 125 Glu Lys Ala Phe Pro Tyr Leu Ser Thr Lys His Leu Gly Val Phe Pro 130 135 140 Asp His Val Ile Asp Met Phe Ile Asn Gly Tyr Arg Leu Ser Leu Thr 145 150 155 160 Asn His Gly Pro Thr Pro Val Lys Glu Gly Ser Lys Asp Pro Arg Gly 165 170 175 Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp Gln Ser Lys Leu Leu 180 185 190 Thr Ser Arg His Asp Phe Lys Glu Lys Asn Leu Lys Glu Ile Ser Asp 195 200 205 Leu Ile Lys Lys Glu Leu Thr Glu Gly Lys Ala Leu Gly Leu Ser His 210 215 220 Thr Tyr Ala Asn Val Arg Ile Asn His Val Ile Asn Leu Trp Gly Ala 225 230 235 240 Asp Phe Asp Ser Asn Gly Asn Leu Lys Ala Ile Tyr Val Thr Asp Ser 245 250 255 Asp Ser Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe Val Gly Val Asn 260 265 270 Ser Ala Gly Lys Val Ala Ile Ser Ala Lys Glu Ile Lys Glu Asp Asn 275 280 285 Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu Ser Thr Gly Gln Asp 290 295 300 Ser Trp Asn Gln Thr Asn 305 310 <210> 3 <211> 310 <212> PRT <213> Streptococcus pyogenes <400> 3 Asp Ser Phe Ser Ala Asn Gln Glu Ile Arg Tyr Ser Glu Val Thr Pro 1 5 10 15 Tyr His Val Thr Ser Val Trp Thr Lys Gly Val Thr Pro Pro Ala Asn 20 25 30 Phe Thr Gln Gly Glu Asp Val Phe His Ala Pro Tyr Val Ala Asn Gln 35 40 45 Gly Trp Tyr Asp Ile Thr Lys Thr Phe Asn Gly Lys Asp Asp Leu Leu 50 55 60 Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe Asp Gln 65 70 75 80 Asn Lys Asp Gln Ile Lys Arg Tyr Leu Glu Glu His Pro Glu Lys Gln 85 90 95 Lys Ile Asn Phe Arg Gly Glu Gln Met Phe Asp Val Lys Glu Ala Ile 100 105 110 Asp Thr Lys Asn His Gln Leu Asp Ser Lys Leu Phe Glu Tyr Phe Lys 115 120 125 Glu Lys Ala Phe Pro Tyr Leu Ser Thr Lys His Leu Gly Val Phe Pro 130 135 140 Asp His Val Ile Asp Met Phe Ile Asn Gly Tyr Arg Leu Ser Leu Thr 145 150 155 160 Asn His Gly Pro Thr Pro Val Lys Glu Gly Ser Lys Asp Pro Arg Gly 165 170 175 Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp Gln Ser Lys Leu Leu 180 185 190 Thr Ser Arg His Asp Phe Lys Glu Lys Asn Leu Lys Glu Ile Ser Asp 195 200 205 Leu Ile Lys Lys Glu Leu Thr Glu Gly Lys Ala Leu Gly Leu Ser His 210 215 220 Thr Tyr Ala Asn Val Arg Ile Asn His Val Ile Asn Leu Trp Gly Ala 225 230 235 240 Asp Phe Asp Ser Asn Gly Asn Leu Lys Ala Ile Tyr Val Thr Asp Ser 245 250 255 Asp Ser Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe Val Gly Val Asn 260 265 270 Ser Ala Gly Lys Val Ala Ile Ser Ala Lys Glu Ile Lys Glu Asp Asn 275 280 285 Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu Ser Thr Gly Gln Asp 290 295 300 Ser Trp Asn Gln Thr Asn 305 310 <210> 4 <211> 310 <212> PRT <213> Streptococcus pyogenes <400> 4 Asp Ser Phe Ser Ala Asn Gln Glu Ile Arg Tyr Ser Glu Val Thr Pro 1 5 10 15 Tyr His Val Thr Ser Val Trp Thr Lys Gly Val Thr Pro Pro Ala Asn 20 25 30 Phe Thr Gln Gly Glu Asp Val Phe His Ala Pro Tyr Val Ala Asn Gln 35 40 45 Gly Trp Tyr Asp Ile Thr Lys Thr Phe Asn Gly Lys Asp Asp Leu Leu 50 55 60 Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe Asp Gln 65 70 75 80 Asn Lys Asp Gln Ile Lys Arg Tyr Leu Glu Glu His Pro Glu Lys Gln 85 90 95 Lys Ile Asn Phe Lys Gly Glu Gln Met Phe Asp Val Lys Glu Ala Ile 100 105 110 Asp Thr Lys Asn His Gln Leu Asp Ser Lys Leu Phe Glu Tyr Phe Lys 115 120 125 Glu Lys Ala Phe Pro Tyr Leu Ser Thr Lys His Leu Gly Val Phe Pro 130 135 140 Asp His Val Ile Asp Met Phe Ile Asn Gly Tyr Arg Leu Ser Leu Thr 145 150 155 160 Asn His Gly Pro Thr Pro Val Lys Arg Gly Ser Lys Asp Pro Arg Gly 165 170 175 Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asn Gln Ser Lys Leu Leu 180 185 190 Thr Ser Arg His Asp Phe Lys Glu Lys Asn Leu Lys Glu Ile Ser Asp 195 200 205 Leu Ile Lys Lys Glu Leu Thr Glu Gly Lys Ala Leu Gly Leu Ser His 210 215 220 Thr Tyr Ala Asn Val Arg Ile Asn His Val Ile Asn Leu Trp Gly Ala 225 230 235 240 Asp Phe Asp Ser Asn Gly Asn Leu Lys Ala Ile Tyr Val Thr Asp Ser 245 250 255 Asp Ser Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe Val Gly Val Asn 260 265 270 Ser Ala Gly Lys Val Ala Ile Ser Ala Lys Glu Ile Lys Glu Asp Asn 275 280 285 Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu Ser Thr Gly Gln Asp 290 295 300 Ser Trp Asn Gln Thr Asn 305 310 <210> 5 <211> 310 <212> PRT <213> Streptococcus pyogenes <400> 5 Asp Ser Phe Ser Ala Asn Gln Glu Ile Arg Tyr Ser Glu Val Thr Pro 1 5 10 15 Tyr His Val Thr Ser Val Trp Thr Lys Gly Val Thr Pro Pro Ala Asn 20 25 30 Phe Thr Gln Gly Glu Asp Val Phe His Ala Pro Tyr Val Ala Asn Gln 35 40 45 Gly Trp Tyr Asp Ile Thr Lys Thr Phe Asn Gly Lys Asp Asp Leu Leu 50 55 60 Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe Asp Gln 65 70 75 80 Asn Lys Asp Gln Ile Lys Arg Tyr Leu Glu Glu His Pro Glu Lys Gln 85 90 95 Lys Ile Asn Phe Arg Gly Glu Gln Met Phe Asp Val Lys Glu Ala Ile 100 105 110 Asp Thr Lys Asn His Gln Leu Asp Ser Lys Leu Phe Glu Tyr Phe Lys 115 120 125 Glu Lys Ala Phe Pro Tyr Leu Ser Thr Lys His Leu Gly Val Phe Pro 130 135 140 Asp His Val Ile Asp Met Phe Ile Asn Gly Tyr Arg Leu Ser Leu Thr 145 150 155 160 Asn His Gly Pro Thr Pro Val Lys Lys Gly Ser Lys Asp Pro Arg Gly 165 170 175 Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asn Gln Ser Lys Leu Leu 180 185 190 Thr Ser Arg His Asp Phe Lys Glu Lys Asn Leu Lys Glu Ile Ser Asp 195 200 205 Leu Ile Lys Lys Glu Leu Thr Glu Gly Lys Ala Leu Gly Leu Ser His 210 215 220 Thr Tyr Ala Asn Val Arg Ile Asn His Val Ile Asn Leu Trp Gly Ala 225 230 235 240 Asp Phe Asp Ser Asn Gly Asn Leu Lys Ala Ile Tyr Val Thr Asp Ser 245 250 255 Asp Ser Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe Val Gly Val Asn 260 265 270 Lys Ala Gly Lys Val Ala Ile Ser Ala Lys Glu Ile Lys Glu Asp Asn 275 280 285 Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu Ser Thr Gly Gln Asp 290 295 300 Ser Trp Asn Gln Thr Asn 305 310 <210> 6 <211> 310 <212> PRT <213> Streptococcus pyogenes <400> 6 Asp Ser Phe Ser Ala Asn Gln Glu Ile Arg Tyr Ser Glu Val Thr Pro 1 5 10 15 Tyr His Val Thr Ser Val Trp Thr Lys Gly Val Thr Pro Pro Ala Asn 20 25 30 Phe Thr Gln Gly Glu Asp Val Phe His Ala Pro Tyr Val Ala Asn Gln 35 40 45 Gly Trp Tyr Asp Ile Thr Lys Thr Phe Asn Gly Lys Asp Asp Leu Leu 50 55 60 Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe Asp Gln 65 70 75 80 Asn Lys Asp Gln Ile Lys Arg Tyr Leu Arg Glu His Pro Glu Lys Gln 85 90 95 Lys Ile Asn Phe Asn Gly Glu Gln Met Phe Asp Val Lys Glu Ala Ile 100 105 110 Asp Thr Lys Asn His Gln Leu Asp Ser Lys Leu Phe Glu Tyr Phe Lys 115 120 125 Glu Lys Ala Phe Pro Tyr Leu Ser Thr Lys His Leu Gly Val Phe Pro 130 135 140 Asp His Val Ile Asp Met Phe Ile Asn Gly Tyr Arg Leu Ser Leu Thr 145 150 155 160 Asn His Gly Pro Thr Pro Val Lys Glu Gly Ser Lys Asp Pro Arg Gly 165 170 175 Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asn Gln Ser Lys Leu Leu 180 185 190 Thr Ser Arg His Asp Phe Lys Glu Lys Asn Leu Lys Glu Ile Ser Asp 195 200 205 Leu Ile Lys Lys Glu Leu Asp Glu Gly Lys Ala Leu Gly Leu Ser His 210 215 220 Thr Tyr Ala Asn Val Arg Ile Asn His Val Ile Asn Leu Trp Gly Ala 225 230 235 240 Asp Phe Asp Ser Asn Gly Asn Leu Lys Ala Ile Tyr Val Thr Asp Ser 245 250 255 Asp Ser Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe Val Gly Val Asn 260 265 270 Ser Ala Gly Lys Val Ala Ile Ser Ala Lys Glu Ile Lys Glu Asp Asn 275 280 285 Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu Ser Thr Gly Gln Asp 290 295 300 Ser Trp Asn Gln Thr Asn 305 310 <210> 7 <211> 310 <212> PRT <213> Streptococcus pyogenes <400> 7 Asp Ser Phe Ser Ala Asn Gln Glu Ile Arg Tyr Ser Glu Val Thr Pro 1 5 10 15 Tyr His Val Thr Ser Val Trp Thr Lys Gly Val Thr Pro Pro Ala Asn 20 25 30 Phe Thr Gln Gly Glu Asp Val Phe His Ala Pro Tyr Val Ala Asn Gln 35 40 45 Gly Trp Tyr Asp Ile Thr Lys Thr Phe Asn Gly Lys Asp Asp Leu Leu 50 55 60 Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe Asp Gln 65 70 75 80 Asn Lys Asp Gln Ile Lys Arg Tyr Leu Lys Glu His Pro Glu Lys Gln 85 90 95 Lys Ile Asn Phe Asn Gly Glu Gln Met Phe Asp Val Lys Glu Ala Ile 100 105 110 Arg Thr Lys Asn His Gln Leu Asp Ser Lys Leu Phe Glu Tyr Phe Lys 115 120 125 Glu Lys Ala Phe Pro Tyr Leu Ser Thr Lys His Leu Gly Val Phe Pro 130 135 140 Asp His Val Ile Asp Met Phe Ile Asn Gly Tyr Arg Leu Ser Leu Thr 145 150 155 160 Asn His Gly Pro Thr Pro Val Lys Glu Gly Ser Lys Asp Pro Arg Gly 165 170 175 Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asn Gln Ser Lys Leu Leu 180 185 190 Thr Ser Arg His Asp Phe Lys Glu Lys Asn Leu Lys Glu Ile Ser Asp 195 200 205 Leu Ile Lys Lys Glu Leu Glu Glu Gly Lys Ala Leu Gly Leu Ser His 210 215 220 Thr Tyr Ala Asn Val Arg Ile Asn His Val Ile Asn Leu Trp Gly Ala 225 230 235 240 Asp Phe Asp Ser Asn Gly Asn Leu Lys Ala Ile Tyr Val Thr Asp Ser 245 250 255 Asp Ser Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe Val Gly Val Asn 260 265 270 Lys Ala Gly Lys Val Ala Ile Ser Ala Lys Glu Ile Lys Glu Asp Asn 275 280 285 Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu Ser Thr Gly Gln Asp 290 295 300 Ser Trp Asn Gln Thr Asn 305 310 <210> 8 <211> 310 <212> PRT <213> Streptococcus pyogenes <400> 8 Asp Ser Phe Ser Ala Asn Gln Glu Ile Arg Tyr Ser Glu Val Thr Pro 1 5 10 15 Tyr His Val Thr Ser Val Trp Thr Lys Gly Val Thr Pro Pro Ala Asn 20 25 30 Phe Thr Gln Gly Glu Asp Val Phe His Ala Pro Tyr Val Ala Asn Gln 35 40 45 Gly Trp Tyr Asp Ile Thr Lys Thr Phe Asn Gly Lys Asp Asp Leu Leu 50 55 60 Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe Asp Gln 65 70 75 80 Asn Lys Asp Gln Ile Glu Arg Tyr Leu Glu Glu His Pro Glu Lys Gln 85 90 95 Lys Ile Asn Phe Asn Gly Glu Gln Met Phe Asp Val Lys Glu Ala Ile 100 105 110 Asp Thr Lys Asn His Gln Leu Asp Ser Lys Leu Phe Glu Tyr Phe Lys 115 120 125 Glu Lys Ala Phe Pro Tyr Leu Ser Thr Lys His Leu Gly Val Phe Pro 130 135 140 Asp His Val Ile Asp Met Phe Ile Asn Gly Tyr Arg Leu Ser Leu Thr 145 150 155 160 Asn His Gly Pro Thr Pro Val Lys Glu Gly Ser Lys Asp Pro Arg Gly 165 170 175 Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asn Gln Ser Lys Leu Leu 180 185 190 Thr Ser Arg His Asp Phe Lys Glu Lys Asn Leu Lys Glu Ile Ser Asp 195 200 205 Leu Ile Lys Glu Glu Leu Thr Lys Gly Lys Ala Leu Gly Leu Ser His 210 215 220 Thr Tyr Ala Asn Val Arg Ile Asn His Val Ile Asn Leu Trp Gly Ala 225 230 235 240 Asp Phe Asp Ser Asn Gly Asn Leu Lys Ala Ile Tyr Val Thr Asp Ser 245 250 255 Asp Ser Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe Val Gly Val Asn 260 265 270 Ser Ala Gly Lys Val Ala Ile Ser Ala Lys Glu Ile Lys Glu Lys Asn 275 280 285 Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu Ser Thr Gly Gln Lys 290 295 300 Ser Trp Asn Gln Thr Asn 305 310 <210> 9 <211> 310 <212> PRT <213> Streptococcus pyogenes <400> 9 Asp Ser Phe Ser Ala Asn Gln Glu Ile Arg Tyr Ser Glu Val Thr Pro 1 5 10 15 Tyr His Val Thr Ser Val Trp Thr Lys Gly Val Thr Pro Pro Ala Asn 20 25 30 Phe Thr Gln Gly Glu Asp Val Phe His Ala Pro Tyr Val Ala Asn Gln 35 40 45 Gly Trp Tyr Asp Ile Thr Lys Thr Phe Asn Gly Lys Asp Asp Leu Leu 50 55 60 Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe Asp Gln 65 70 75 80 Asn Lys Asp Gln Ile Lys Arg Tyr Leu Lys Glu His Pro Glu Lys Gln 85 90 95 Lys Ile Asn Phe Arg Gly Glu Gln Met Phe Asp Val Lys Glu Ala Ile 100 105 110 Arg Thr Lys Asn His Gln Leu Asp Ser Lys Leu Phe Glu Tyr Phe Lys 115 120 125 Glu Lys Ala Phe Pro Tyr Leu Ser Thr Lys His Leu Gly Val Phe Pro 130 135 140 Asp His Val Ile Asp Met Phe Ile Asn Gly Tyr Arg Leu Ser Leu Thr 145 150 155 160 Asn His Gly Pro Thr Pro Val Lys Glu Gly Ser Lys Asp Pro Arg Gly 165 170 175 Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asn Gln Ser Lys Leu Leu 180 185 190 Thr Ser Arg His Asp Phe Lys Glu Lys Asn Leu Lys Glu Ile Ser Asp 195 200 205 Leu Ile Lys Ser Glu Leu Glu Asn Gly Lys Ala Leu Gly Leu Ser His 210 215 220 Thr Tyr Ala Asn Val Arg Ile Asn His Val Ile Asn Leu Trp Gly Ala 225 230 235 240 Asp Phe Asp Ser Asn Gly Asn Leu Lys Ala Ile Tyr Val Thr Asp Ser 245 250 255 Asp Ser Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe Val Gly Val Asn 260 265 270 Lys Ala Gly Lys Val Ala Ile Ser Ala Lys Glu Ile Lys Glu Asp Asn 275 280 285 Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu Ser Thr Gly Gln Asp 290 295 300 Ser Trp Asn Gln Thr Asn 305 310 <210> 10 <211> 310 <212> PRT <213> Streptococcus pyogenes <400> 10 Asp Ser Phe Ser Ala Asn Gln Glu Ile Arg Tyr Ser Glu Val Thr Pro 1 5 10 15 Tyr His Val Thr Ser Val Trp Thr Lys Gly Val Thr Pro Pro Ala Asn 20 25 30 Phe Thr Gln Gly Glu Asp Val Phe His Ala Pro Tyr Val Ala Asn Gln 35 40 45 Gly Trp Tyr Asp Ile Thr Lys Thr Phe Asn Gly Lys Asp Asp Leu Leu 50 55 60 Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe Asp Gln 65 70 75 80 Asn Lys Asp Gln Ile Lys Arg Tyr Leu Lys Glu His Pro Glu Lys Gln 85 90 95 Lys Ile Asn Phe Arg Gly Glu Gln Met Phe Asp Val Lys Glu Ala Ile 100 105 110 Arg Thr Lys Asn His Gln Leu Asp Ser Lys Leu Phe Glu Tyr Phe Lys 115 120 125 Glu Lys Ala Phe Pro Tyr Leu Ser Thr Lys His Leu Gly Val Phe Pro 130 135 140 Asp His Val Ile Asp Met Phe Ile Asn Gly Tyr Arg Leu Ser Leu Thr 145 150 155 160 Asn His Gly Pro Thr Pro Val Lys Lys Gly Ser Lys Asp Pro Arg Gly 165 170 175 Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asn Gln Ser Lys Leu Leu 180 185 190 Thr Ser Arg His Asp Phe Lys Glu Lys Asn Leu Lys Glu Ile Ser Asp 195 200 205 Leu Ile Lys Lys Glu Leu Glu Glu Gly Lys Ala Leu Gly Leu Ser His 210 215 220 Thr Tyr Ala Asn Val Arg Ile Asn His Val Ile Asn Leu Trp Gly Ala 225 230 235 240 Asp Phe Asp Ser Asn Gly Asn Leu Lys Ala Ile Tyr Val Thr Asp Ser 245 250 255 Asp Ser Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe Val Gly Val Asn 260 265 270 Ser Ala Gly Lys Val Ala Ile Ser Ala Lys Glu Ile Lys Glu Asp Asn 275 280 285 Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu Ser Thr Gly Gln Asp 290 295 300 Ser Trp Asn Gln Thr Asn 305 310 <210> 11 <211> 310 <212> PRT <213> Streptococcus pyogenes <400> 11 Asp Ser Phe Ser Ala Asn Gln Glu Ile Arg Tyr Ser Glu Val Thr Pro 1 5 10 15 Tyr His Val Thr Ser Val Trp Thr Lys Gly Val Thr Pro Pro Ala Asn 20 25 30 Phe Thr Gln Gly Glu Asp Val Phe His Ala Pro Tyr Val Ala Asn Gln 35 40 45 Gly Trp Tyr Asp Ile Thr Lys Thr Phe Asn Gly Lys Asp Asp Leu Leu 50 55 60 Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe Asp Gln 65 70 75 80 Asn Lys Asp Gln Ile Glu Arg Tyr Leu Glu Glu His Pro Glu Lys Gln 85 90 95 Lys Ile Asn Phe Arg Gly Glu Gln Met Phe Asp Val Lys Glu Ala Ile 100 105 110 Asp Thr Lys Asn His Gln Leu Asp Ser Lys Leu Phe Glu Tyr Phe Lys 115 120 125 Glu Lys Ala Phe Pro Tyr Leu Ser Thr Lys His Leu Gly Val Phe Pro 130 135 140 Asp His Val Ile Asp Met Phe Ile Asn Gly Tyr Arg Leu Ser Leu Thr 145 150 155 160 Asn His Gly Pro Thr Pro Val Lys Lys Gly Ser Lys Asp Pro Arg Gly 165 170 175 Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asn Gln Ser Lys Leu Leu 180 185 190 Thr Ser Arg His Asp Phe Lys Glu Lys Asn Leu Lys Glu Ile Ser Asp 195 200 205 Leu Ile Lys Glu Glu Leu Thr Lys Gly Lys Ala Leu Gly Leu Ser His 210 215 220 Thr Tyr Ala Asn Val Arg Ile Asn His Val Ile Asn Leu Trp Gly Ala 225 230 235 240 Asp Phe Asp Ser Asn Gly Asn Leu Lys Ala Ile Tyr Val Thr Asp Ser 245 250 255 Asp Ser Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe Val Gly Val Asn 260 265 270 Ser Ala Gly Lys Val Ala Ile Ser Ala Lys Glu Ile Lys Glu Asp Asn 275 280 285 Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu Ser Thr Gly Gln Lys 290 295 300 Ser Trp Asn Gln Thr Asn 305 310 <210> 12 <211> 306 <212> PRT <213> Streptococcus pyogenes <400> 12 Asp Ser Phe Ser Ala Asn Gln Glu Ile Arg Tyr Ser Glu Val Thr Pro 1 5 10 15 Tyr His Val Thr Ser Val Trp Thr Lys Gly Val Thr Pro Pro Ala Asn 20 25 30 Phe Thr Gln Gly Glu Asp Val Phe His Ala Pro Tyr Val Ala Asn Gln 35 40 45 Gly Trp Tyr Asp Ile Thr Lys Thr Phe Asn Gly Lys Asp Asp Leu Leu 50 55 60 Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe Asp Gln 65 70 75 80 Asn Lys Asp Gln Ile Lys Arg Tyr Leu Glu Glu His Pro Glu Lys Gln 85 90 95 Lys Ile Asn Phe Asn Gly Glu Gln Met Phe Asp Val Lys Glu Ala Ile 100 105 110 Asp Thr Lys Asn His Gln Leu Asp Ser Lys Leu Phe Glu Tyr Phe Lys 115 120 125 Glu Lys Ala Phe Pro Tyr Leu Ser Thr Lys His Leu Gly Val Phe Pro 130 135 140 Asp His Val Ile Asp Met Phe Ile Asn Gly Tyr Arg Leu Ser Leu Thr 145 150 155 160 Asn His Gly Pro Thr Pro Val Lys Glu Gly Ser Lys Asp Pro Arg Gly 165 170 175 Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp Gln Ser Lys Leu Leu 180 185 190 Thr Ser Arg His Asp Phe Lys Glu Lys Asn Leu Lys Glu Ile Ser Asp 195 200 205 Leu Ile Lys Lys Glu Leu Thr Glu Gly Lys Ala Leu Gly Leu Ser His 210 215 220 Thr Tyr Ala Asn Val Arg Ile Asn His Val Ile Asn Leu Trp Gly Ala 225 230 235 240 Asp Phe Asp Ser Asn Gly Asn Leu Lys Ala Ile Tyr Val Thr Asp Ser 245 250 255 Asp Ser Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe Val Gly Val Asn 260 265 270 Ser Ala Gly Lys Val Ala Ile Ser Ala Lys Glu Ile Lys Glu Asp Asn 275 280 285 Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu Ser Thr Gly Gln Asp 290 295 300 Ser Trp 305 <210> 13 <211> 290 <212> PRT <213> Streptococcus pyogenes <400> 13 Ser Val Trp Thr Lys Gly Val Thr Pro Pro Ala Asn Phe Thr Gln Gly 1 5 10 15 Glu Asp Val Phe His Ala Pro Tyr Val Ala Asn Gln Gly Trp Tyr Asp 20 25 30 Ile Thr Lys Thr Phe Asn Gly Lys Asp Asp Leu Leu Cys Gly Ala Ala 35 40 45 Thr Ala Gly Asn Met Leu His Trp Trp Phe Asp Gln Asn Lys Asp Gln 50 55 60 Ile Lys Arg Tyr Leu Glu Glu His Pro Glu Lys Gln Lys Ile Asn Phe 65 70 75 80 Asn Gly Glu Gln Met Phe Asp Val Lys Glu Ala Ile Asp Thr Lys Asn 85 90 95 His Gln Leu Asp Ser Lys Leu Phe Glu Tyr Phe Lys Glu Lys Ala Phe 100 105 110 Pro Tyr Leu Ser Thr Lys His Leu Gly Val Phe Pro Asp His Val Ile 115 120 125 Asp Met Phe Ile Asn Gly Tyr Arg Leu Ser Leu Thr Asn His Gly Pro 130 135 140 Thr Pro Val Lys Glu Gly Ser Lys Asp Pro Arg Gly Gly Ile Phe Asp 145 150 155 160 Ala Val Phe Thr Arg Gly Asp Gln Ser Lys Leu Leu Thr Ser Arg His 165 170 175 Asp Phe Lys Glu Lys Asn Leu Lys Glu Ile Ser Asp Leu Ile Lys Lys 180 185 190 Glu Leu Thr Glu Gly Lys Ala Leu Gly Leu Ser His Thr Tyr Ala Asn 195 200 205 Val Arg Ile Asn His Val Ile Asn Leu Trp Gly Ala Asp Phe Asp Ser 210 215 220 Asn Gly Asn Leu Lys Ala Ile Tyr Val Thr Asp Ser Asp Ser Asn Ala 225 230 235 240 Ser Ile Gly Met Lys Lys Tyr Phe Val Gly Val Asn Ser Ala Gly Lys 245 250 255 Val Ala Ile Ser Ala Lys Glu Ile Lys Glu Asp Asn Ile Gly Ala Gln 260 265 270 Val Leu Gly Leu Phe Thr Leu Ser Thr Gly Gln Asp Ser Trp Asn Gln 275 280 285 Thr Asn 290 <210> 14 <211> 290 <212> PRT <213> Streptococcus pyogenes <400> 14 Ser Val Trp Thr Lys Gly Val Thr Pro Pro Ala Asn Phe Thr Gln Gly 1 5 10 15 Glu Asp Val Phe His Ala Pro Tyr Val Ala Asn Gln Gly Trp Tyr Asp 20 25 30 Ile Thr Lys Thr Phe Asn Gly Lys Asp Asp Leu Leu Cys Gly Ala Ala 35 40 45 Thr Ala Gly Asn Met Leu His Trp Trp Phe Asp Gln Asn Lys Asp Gln 50 55 60 Ile Lys Arg Tyr Leu Glu Glu His Pro Glu Lys Gln Lys Ile Asn Phe 65 70 75 80 Lys Gly Glu Gln Met Phe Asp Val Lys Glu Ala Ile Asp Thr Lys Asn 85 90 95 His Gln Leu Asp Ser Lys Leu Phe Glu Tyr Phe Lys Glu Lys Ala Phe 100 105 110 Pro Tyr Leu Ser Thr Lys His Leu Gly Val Phe Pro Asp His Val Ile 115 120 125 Asp Met Phe Ile Asn Gly Tyr Arg Leu Ser Leu Thr Asn His Gly Pro 130 135 140 Thr Pro Val Lys Glu Gly Ser Lys Asp Pro Arg Gly Gly Ile Phe Asp 145 150 155 160 Ala Val Phe Thr Arg Gly Asn Gln Ser Lys Leu Leu Thr Ser Arg His 165 170 175 Asp Phe Lys Glu Lys Asn Leu Lys Glu Ile Ser Asp Leu Ile Lys Lys 180 185 190 Glu Leu Thr Glu Gly Lys Ala Leu Gly Leu Ser His Thr Tyr Ala Asn 195 200 205 Val Arg Ile Asn His Val Ile Asn Leu Trp Gly Ala Asp Phe Asp Ser 210 215 220 Asn Gly Asn Leu Lys Ala Ile Tyr Val Thr Asp Ser Asp Ser Asn Ala 225 230 235 240 Ser Ile Gly Met Lys Lys Tyr Phe Val Gly Val Asn Ser Ala Gly Lys 245 250 255 Val Ala Ile Ser Ala Lys Glu Ile Lys Glu Asp Asn Ile Gly Ala Gln 260 265 270 Val Leu Gly Leu Phe Thr Leu Ser Thr Gly Gln Asp Ser Trp Asn Gln 275 280 285 Thr Asn 290 <210> 15 <211> 290 <212> PRT <213> Streptococcus pyogenes <400> 15 Ser Val Trp Thr Lys Gly Val Thr Pro Pro Ala Asn Phe Thr Gln Gly 1 5 10 15 Glu Asp Val Phe His Ala Pro Tyr Val Ala Asn Gln Gly Trp Tyr Asp 20 25 30 Ile Thr Lys Thr Phe Asn Gly Lys Asp Asp Leu Leu Cys Gly Ala Ala 35 40 45 Thr Ala Gly Asn Met Leu His Trp Trp Phe Asp Gln Asn Lys Asp Gln 50 55 60 Ile Glu Arg Tyr Leu Glu Glu His Pro Glu Lys Gln Lys Ile Asn Phe 65 70 75 80 Lys Gly Glu Gln Met Phe Asp Val Lys Lys Ala Ile Asp Thr Lys Asn 85 90 95 His Gln Leu Asp Ser Lys Leu Phe Glu Tyr Phe Lys Glu Lys Ala Phe 100 105 110 Pro Tyr Leu Ser Thr Lys His Leu Gly Val Phe Pro Asp His Val Ile 115 120 125 Asp Met Phe Ile Asn Gly Tyr Arg Leu Ser Leu Thr Asn His Gly Pro 130 135 140 Thr Pro Val Lys Glu Gly Ser Lys Asp Pro Arg Gly Gly Ile Phe Asp 145 150 155 160 Ala Val Phe Thr Arg Gly Asn Gln Ser Lys Leu Leu Thr Ser Arg His 165 170 175 Asp Phe Lys Glu Lys Asn Leu Lys Glu Ile Ser Asp Leu Ile Lys Glu 180 185 190 Glu Leu Thr Lys Gly Lys Ala Leu Gly Leu Ser His Thr Tyr Ala Asn 195 200 205 Val Arg Ile Asn His Val Ile Asn Leu Trp Gly Ala Asp Phe Asp Ser 210 215 220 Asn Gly Asn Leu Lys Ala Ile Tyr Val Thr Asp Ser Asp Ser Asn Ala 225 230 235 240 Ser Ile Gly Met Lys Lys Tyr Phe Val Gly Val Asn Ser Ala Gly Lys 245 250 255 Val Ala Ile Ser Ala Lys Glu Ile Lys Glu Asp Asn Ile Gly Ala Gln 260 265 270 Val Leu Gly Leu Phe Thr Leu Ser Thr Gly Gln Lys Ser Trp Asn Gln 275 280 285 Thr Asn 290 <210> 16 <211> 319 <212> PRT <213> Streptococcus pyogenes <400> 16 Asp Asp Tyr Gln Arg Asn Ala Thr Glu Ala Tyr Ala Lys Glu Val Pro 1 5 10 15 His Gln Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Pro Ala Asn 20 25 30 Phe Thr Gln Gly Glu Asp Val Phe His Ala Pro Tyr Val Ala Asn Gln 35 40 45 Gly Trp Tyr Asp Ile Thr Lys Thr Phe Asn Gly Lys Asp Asp Leu Leu 50 55 60 Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe Asp Gln 65 70 75 80 Asn Lys Asp Gln Ile Glu Arg Tyr Leu Glu Glu His Pro Glu Lys Gln 85 90 95 Lys Ile Asn Phe Lys Gly Glu Gln Met Phe Asp Val Lys Lys Ala Ile 100 105 110 Asp Thr Lys Asn His Gln Leu Asp Ser Lys Leu Phe Glu Tyr Phe Lys 115 120 125 Glu Lys Ala Phe Pro Tyr Leu Ser Thr Lys His Leu Gly Val Phe Pro 130 135 140 Asp His Val Ile Asp Met Phe Ile Asn Gly Tyr Arg Leu Ser Leu Thr 145 150 155 160 Asn His Gly Pro Thr Pro Val Lys Glu Gly Ser Lys Asp Pro Arg Gly 165 170 175 Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asn Gln Ser Lys Leu Leu 180 185 190 Thr Ser Arg His Asp Phe Lys Glu Lys Asn Leu Lys Glu Ile Ser Asp 195 200 205 Leu Ile Lys Glu Glu Leu Thr Lys Gly Lys Ala Leu Gly Leu Ser His 210 215 220 Thr Tyr Ala Asn Val Arg Ile Asn His Val Ile Asn Leu Trp Gly Ala 225 230 235 240 Asp Phe Asp Ser Asn Gly Asn Leu Lys Ala Ile Tyr Val Thr Asp Ser 245 250 255 Asp Ser Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe Val Gly Val Asn 260 265 270 Ser Ala Gly Lys Val Ala Ile Ser Ala Lys Glu Ile Lys Glu Asp Asn 275 280 285 Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu Ser Thr Gly Gln Lys 290 295 300 Ser Trp Asn Gln Thr Asn Gly Gly Gly His His His His His His 305 310 315 <210> 17 <211> 320 <212> PRT <213> Streptococcus pyogenes <400> 17 Met Asp Ser Phe Ser Ala Asn Gln Glu Ile Arg Tyr Ser Glu Val Thr 1 5 10 15 Pro Tyr His Val Thr Ser Val Trp Thr Lys Gly Val Thr Pro Pro Ala 20 25 30 Asn Phe Thr Gln Gly Glu Asp Val Phe His Ala Pro Tyr Val Ala Asn 35 40 45 Gln Gly Trp Tyr Asp Ile Thr Lys Thr Phe Asn Gly Lys Asp Asp Leu 50 55 60 Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe Asp 65 70 75 80 Gln Asn Lys Asp Gln Ile Lys Arg Tyr Leu Glu Glu His Pro Glu Lys 85 90 95 Gln Lys Ile Asn Phe Asn Gly Glu Gln Met Phe Asp Val Lys Glu Ala 100 105 110 Ile Asp Thr Lys Asn His Gln Leu Asp Ser Lys Leu Phe Glu Tyr Phe 115 120 125 Lys Glu Lys Ala Phe Pro Tyr Leu Ser Thr Lys His Leu Gly Val Phe 130 135 140 Pro Asp His Val Ile Asp Met Phe Ile Asn Gly Tyr Arg Leu Ser Leu 145 150 155 160 Thr Asn His Gly Pro Thr Pro Val Lys Glu Gly Ser Lys Asp Pro Arg 165 170 175 Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp Gln Ser Lys Leu 180 185 190 Leu Thr Ser Arg His Asp Phe Lys Glu Lys Asn Leu Lys Glu Ile Ser 195 200 205 Asp Leu Ile Lys Lys Glu Leu Thr Glu Gly Lys Ala Leu Gly Leu Ser 210 215 220 His Thr Tyr Ala Asn Val Arg Ile Asn His Val Ile Asn Leu Trp Gly 225 230 235 240 Ala Asp Phe Asp Ser Asn Gly Asn Leu Lys Ala Ile Tyr Val Thr Asp 245 250 255 Ser Asp Ser Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe Val Gly Val 260 265 270 Asn Ser Ala Gly Lys Val Ala Ile Ser Ala Lys Glu Ile Lys Glu Asp 275 280 285 Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu Ser Thr Gly Gln 290 295 300 Asp Ser Trp Asn Gln Thr Asn Gly Gly Gly His His His His His His 305 310 315 320 <210> 18 <211> 4 <212> PRT <213> Streptococcus pyogenes <400> 18 Asn Gln Thr Asn 1 <210> 19 <211> 20 <212> PRT <213> Streptococcus pyogenes <400> 19 Asp Ser Phe Ser Ala Asn Gln Glu Ile Arg Tyr Ser Glu Val Thr Pro 1 5 10 15 Tyr His Val Thr 20 <210> 20 <211> 963 <212> DNA <213> Streptococcus pyogenes <400> 20 atggatagtt tttctgctaa tcaagagatt agatattcgg aagtaacacc ttatcacgtt 60 acttccgttt ggaccaaagg agttactcct ccagcaaact tcactcaagg tgaagatgtt 120 tttcacgctc cttatgttgc taaccaagga tggtatgata ttaccaaaac attcaatgga 180 aaagacgatc ttctttgcgg ggctgccaca gcagggaata tgcttcactg gtggttcgat 240 caaaacaaag accaaattaa acgttatttg gaagagcatc cagaaaagca aaaaataaac 300 ttcaatggcg aacagatgtt tgacgtaaaa gaagctatcg acactaaaaa ccaccagcta 360 gatagtaaat tatttgaata ttttaaagaa aaagctttcc cttatctatc tactaaacac 420 ctaggagttt tccctgatca tgtaattgat atgttcatta acggctaccg ccttagtcta 480 actaaccacg gtccaacgcc agtaaaagaa ggtagtaaag atccccgagg tggtattttt 540 gacgccgtat ttacaagagg tgatcaaagt aagctattga caagtcgtca tgattttaaa 600 gaaaaaaatc tcaaagaaat cagtgatctc attaagaaag agttaaccga aggcaaggct 660 ctaggcctat cacacaccta cgctaacgta cgcatcaacc atgttataaa cctgtgggga 720 gctgactttg attctaacgg gaaccttaaa gctatttatg taacagactc tgatagtaat 780 gcatctattg gtatgaagaa atactttgtt ggtgttaatt ccgctggaaa agtagctatt 840 tctgctaaag aaataaaaga agataatata ggtgctcaag tactagggtt atttacactt 900 tcaacagggc aagatagttg gaatcagacc aatggcggtg gccatcatca ccatcaccac 960 taa 963 <210> 21 <211> 963 <212> DNA <213> Streptococcus pyogenes <400> 21 atggatagtt tttctgctaa tcaagagatt agatattcgg aagtaacacc ttatcacgtt 60 acttccgttt ggaccaaagg agttactcct ccagcaaact tcactcaagg tgaagatgtt 120 tttcacgctc cttatgttgc taaccaagga tggtatgata ttaccaaaac attcaatgga 180 aaagacgatc ttctttgcgg ggctgccaca gcagggaata tgcttcactg gtggttcgat 240 caaaacaaag accaaattaa acgttatttg gaagagcatc cagaaaagca aaaaataaac 300 ttccgtggcg aacagatgtt tgacgtaaaa gaagctatcg acactaaaaa ccaccagcta 360 gatagtaaat tatttgaata ttttaaagaa aaagctttcc cttatctatc tactaaacac 420 ctaggagttt tccctgatca tgtaattgat atgttcatta acggctaccg ccttagtcta 480 actaaccacg gtccaacgcc agtaaaagaa ggtagtaaag atccccgagg tggtattttt 540 gacgccgtat ttacaagagg tgatcaaagt aagctattga caagtcgtca tgattttaaa 600 gaaaaaaatc tcaaagaaat cagtgatctc attaagaaag agttaaccga aggcaaggct 660 ctaggcctat cacacaccta cgctaacgta cgcatcaacc atgttataaa cctgtgggga 720 gctgactttg attctaacgg gaaccttaaa gctatttatg taacagactc tgatagtaat 780 gcatctattg gtatgaagaa atactttgtt ggtgttaatt ccgctggaaa agtagctatt 840 tctgctaaag aaataaaaga agataatata ggtgctcaag tactagggtt atttacactt 900 tcaacagggc aagatagttg gaatcagacc aatggcggtg gccatcatca ccatcaccac 960 taa 963 <210> 22 <211> 963 <212> DNA <213> Streptococcus pyogenes <400> 22 atggatagtt tttctgctaa tcaagagatt agatattcgg aagtaacacc ttatcacgtt 60 acttccgttt ggaccaaagg agttactcct ccagcaaact tcactcaagg tgaagatgtt 120 tttcacgctc cttatgttgc taaccaagga tggtatgata ttaccaaaac attcaatgga 180 aaagacgatc ttctttgcgg ggctgccaca gcagggaata tgcttcactg gtggttcgat 240 caaaacaaag accaaattaa acgttatttg gaagagcatc cagaaaagca aaaaataaac 300 ttcaaaggcg aacagatgtt tgacgtaaaa gaagctatcg acactaaaaa ccaccagcta 360 gatagtaaat tatttgaata ttttaaagaa aaagctttcc cttatctatc tactaaacac 420 ctaggagttt tccctgatca tgtaattgat atgttcatta acggctaccg ccttagtcta 480 actaaccacg gtccaacgcc agtaaaacgt ggtagtaaag atccccgagg tggtattttt 540 gacgccgtat ttacaagagg taaccaaagt aagctattga caagtcgtca tgattttaaa 600 gaaaaaaatc tcaaagaaat cagtgatctc attaagaaag agttaaccga aggcaaggct 660 ctaggcctat cacacaccta cgctaacgta cgcatcaacc atgttataaa cctgtgggga 720 gctgactttg attctaacgg gaaccttaaa gctatttatg taacagactc tgatagtaat 780 gcatctattg gtatgaagaa atactttgtt ggtgttaatt ccgctggaaa agtagctatt 840 tctgctaaag aaataaaaga agataatata ggtgctcaag tactagggtt atttacactt 900 tcaacagggc aagatagttg gaatcagacc aatggcggtg gccatcatca ccatcaccac 960 taa 963 <210> 23 <211> 963 <212> DNA <213> Streptococcus pyogenes <400> 23 atggatagtt tttctgctaa tcaagagatt agatattcgg aagtaacacc ttatcacgtt 60 acttccgttt ggaccaaagg agttactcct ccagcaaact tcactcaagg tgaagatgtt 120 tttcacgctc cttatgttgc taaccaagga tggtatgata ttaccaaaac attcaatgga 180 aaagacgatc ttctttgcgg ggctgccaca gcagggaata tgcttcactg gtggttcgat 240 caaaacaaag accaaattaa acgttatttg gaagagcatc cagaaaagca aaaaataaac 300 ttccgtggcg aacagatgtt tgacgtaaaa gaagctatcg acactaaaaa ccaccagcta 360 gatagtaaat tatttgaata ttttaaagaa aaagctttcc cttatctatc tactaaacac 420 ctaggagttt tccctgatca tgtaattgat atgttcatta acggctaccg ccttagtcta 480 actaaccacg gtccaacgcc agtaaaaaaa ggtagtaaag atccccgagg tggtattttt 540 gacgccgtat ttacaagagg taaccaaagt aagctattga caagtcgtca tgattttaaa 600 gaaaaaaatc tcaaagaaat cagtgatctc attaagaaag agttaaccga aggcaaggct 660 ctaggcctat cacacaccta cgctaacgta cgcatcaacc atgttataaa cctgtgggga 720 gctgactttg attctaacgg gaaccttaaa gctatttatg taacagactc tgatagtaat 780 gcatctattg gtatgaagaa atactttgtt ggtgttaata aagctggaaa agtagctatt 840 tctgctaaag aaataaaaga agataatata ggtgctcaag tactagggtt atttacactt 900 tcaacagggc aagatagttg gaatcagacc aatggcggtg gccatcatca ccatcaccac 960 taa 963 <210> 24 <211> 963 <212> DNA <213> Streptococcus pyogenes <400> 24 atggatagtt tttctgctaa tcaagagatt agatattcgg aagtaacacc ttatcacgtt 60 acttccgttt ggaccaaagg agttactcct ccagcaaact tcactcaagg tgaagatgtt 120 tttcacgctc cttatgttgc taaccaagga tggtatgata ttaccaaaac attcaatgga 180 aaagacgatc ttctttgcgg ggctgccaca gcagggaata tgcttcactg gtggttcgat 240 caaaacaaag accaaattaa acgttatttg cgtgagcatc cagaaaagca aaaaataaac 300 ttcaatggcg aacagatgtt tgacgtaaaa gaagctatcg acactaaaaa ccaccagcta 360 gatagtaaat tatttgaata ttttaaagaa aaagctttcc cttatctatc tactaaacac 420 ctaggagttt tccctgatca tgtaattgat atgttcatta acggctaccg ccttagtcta 480 actaaccacg gtccaacgcc agtaaaagaa ggtagtaaag atccccgagg tggtattttt 540 gacgccgtat ttacaagagg taaccaaagt aagctattga caagtcgtca tgattttaaa 600 gaaaaaaatc tcaaagaaat cagtgatctc attaagaaag agttagatga aggcaaggct 660 ctaggcctat cacacaccta cgctaacgta cgcatcaacc atgttataaa cctgtgggga 720 gctgactttg attctaacgg gaaccttaaa gctatttatg taacagactc tgatagtaat 780 gcatctattg gtatgaagaa atactttgtt ggtgttaatt ccgctggaaa agtagctatt 840 tctgctaaag aaataaaaga agataatata ggtgctcaag tactagggtt atttacactt 900 tcaacagggc aagatagttg gaatcagacc aatggcggtg gccatcatca ccatcaccac 960 taa 963 <210> 25 <211> 963 <212> DNA <213> Streptococcus pyogenes <400> 25 atggatagtt tttctgctaa tcaagagatt agatattcgg aagtaacacc ttatcacgtt 60 acttccgttt ggaccaaagg agttactcct ccagcaaact tcactcaagg tgaagatgtt 120 tttcacgctc cttatgttgc taaccaagga tggtatgata ttaccaaaac attcaatgga 180 aaagacgatc ttctttgcgg ggctgccaca gcagggaata tgcttcactg gtggttcgat 240 caaaacaaag accaaattaa acgttatttg aaagagcatc cagaaaagca aaaaataaac 300 ttcaatggcg aacagatgtt tgacgtaaaa gaagctatcc gtactaaaaa ccaccagcta 360 gatagtaaat tatttgaata ttttaaagaa aaagctttcc cttatctatc tactaaacac 420 ctaggagttt tccctgatca tgtaattgat atgttcatta acggctaccg ccttagtcta 480 actaaccacg gtccaacgcc agtaaaagaa ggtagtaaag atccccgagg tggtattttt 540 gacgccgtat ttacaagagg taaccaaagt aagctattga caagtcgtca tgattttaaa 600 gaaaaaaatc tcaaagaaat cagtgatctc attaagaaag agttagaaga aggcaaggct 660 ctaggcctat cacacaccta cgctaacgta cgcatcaacc atgttataaa cctgtgggga 720 gctgactttg attctaacgg gaaccttaaa gctatttatg taacagactc tgatagtaat 780 gcatctattg gtatgaagaa atactttgtt ggtgttaata aagctggaaa agtagctatt 840 tctgctaaag aaataaaaga agataatata ggtgctcaag tactagggtt atttacactt 900 tcaacagggc aagatagttg gaatcagacc aatggcggtg gccatcatca ccatcaccac 960 taa 963 <210> 26 <211> 963 <212> DNA <213> Streptococcus pyogenes <400> 26 atggatagtt tttctgctaa tcaagagatt agatattcgg aagtaacacc ttatcacgtt 60 acttccgttt ggaccaaagg agttactcct ccagcaaact tcactcaagg tgaagatgtt 120 tttcacgctc cttatgttgc taaccaagga tggtatgata ttaccaaaac attcaatgga 180 aaagacgatc ttctttgcgg ggctgccaca gcagggaata tgcttcactg gtggttcgat 240 caaaacaaag accaaattga acgttatttg gaagagcatc cagaaaagca aaaaataaac 300 ttcaatggcg aacagatgtt tgacgtaaaa gaagctatcg acactaaaaa ccaccagcta 360 gatagtaaat tatttgaata ttttaaagaa aaagctttcc cttatctatc tactaaacac 420 ctaggagttt tccctgatca tgtaattgat atgttcatta acggctaccg ccttagtcta 480 actaaccacg gtccaacgcc agtaaaagaa ggtagtaaag atccccgagg tggtattttt 540 gacgccgtat ttacaagagg taaccaaagt aagctattga caagtcgtca tgattttaaa 600 gaaaaaaatc tcaaagaaat cagtgatctc attaaggaag agttaaccaa aggcaaggct 660 ctaggcctat cacacaccta cgctaacgta cgcatcaacc atgttataaa cctgtgggga 720 gctgactttg attctaacgg gaaccttaaa gctatttatg taacagactc tgatagtaat 780 gcatctattg gtatgaagaa atactttgtt ggtgttaatt ccgctggaaa agtagctatt 840 tctgctaaag aaataaaaga aaaaaatata ggtgctcaag tactagggtt atttacactt 900 tcaacagggc aaaaaagttg gaatcagacc aatggcggtg gccatcatca ccatcaccac 960 taa 963 <210> 27 <211> 963 <212> DNA <213> Streptococcus pyogenes <400> 27 atggatagtt tttctgctaa tcaagagatt agatattcgg aagtaacacc ttatcacgtt 60 acttccgttt ggaccaaagg agttactcct ccagcaaact tcactcaagg tgaagatgtt 120 tttcacgctc cttatgttgc taaccaagga tggtatgata ttaccaaaac attcaatgga 180 aaagacgatc ttctttgcgg ggctgccaca gcagggaata tgcttcactg gtggttcgat 240 caaaacaaag accaaattaa acgttatttg aaagagcatc cagaaaagca aaaaataaac 300 ttccgtggcg aacagatgtt tgacgtaaaa gaagctatcc gtactaaaaa ccaccagcta 360 gatagtaaat tatttgaata ttttaaagaa aaagctttcc cttatctatc tactaaacac 420 ctaggagttt tccctgatca tgtaattgat atgttcatta acggctaccg ccttagtcta 480 actaaccacg gtccaacgcc agtaaaagaa ggtagtaaag atccccgagg tggtattttt 540 gacgccgtat ttacaagagg taaccaaagt aagctattga caagtcgtca tgattttaaa 600 gaaaaaaatc tcaaagaaat cagtgatctc attaagagtg agttagaaaa cggcaaggct 660 ctaggcctat cacacaccta cgctaacgta cgcatcaacc atgttataaa cctgtgggga 720 gctgactttg attctaacgg gaaccttaaa gctatttatg taacagactc tgatagtaat 780 gcatctattg gtatgaagaa atactttgtt ggtgttaata aagctggaaa agtagctatt 840 tctgctaaag aaataaaaga agataatata ggtgctcaag tactagggtt atttacactt 900 tcaacagggc aagatagttg gaatcagacc aatggcggtg gccatcatca ccatcaccac 960 taa 963 <210> 28 <211> 963 <212> DNA <213> Streptococcus pyogenes <400> 28 atggatagtt tttctgctaa tcaagagatt agatattcgg aagtaacacc ttatcacgtt 60 acttccgttt ggaccaaagg agttactcct ccagcaaact tcactcaagg tgaagatgtt 120 tttcacgctc cttatgttgc taaccaagga tggtatgata ttaccaaaac attcaatgga 180 aaagacgatc ttctttgcgg ggctgccaca gcagggaata tgcttcactg gtggttcgat 240 caaaacaaag accaaattaa acgttatttg aaagagcatc cagaaaagca aaaaataaac 300 ttccgtggcg aacagatgtt tgacgtaaaa gaagctatcc gtactaaaaa ccaccagcta 360 gatagtaaat tatttgaata ttttaaagaa aaagctttcc cttatctatc tactaaacac 420 ctaggagttt tccctgatca tgtaattgat atgttcatta acggctaccg ccttagtcta 480 actaaccacg gtccaacgcc agtaaaaaaa ggtagtaaag atccccgagg tggtattttt 540 gacgccgtat ttacaagagg taaccaaagt aagctattga caagtcgtca tgattttaaa 600 gaaaaaaatc tcaaagaaat cagtgatctc attaagaaag agttagaaga aggcaaggct 660 ctaggcctat cacacaccta cgctaacgta cgcatcaacc atgttataaa cctgtgggga 720 gctgactttg attctaacgg gaaccttaaa gctatttatg taacagactc tgatagtaat 780 gcatctattg gtatgaagaa atactttgtt ggtgttaatt ccgctggaaa agtagctatt 840 tctgctaaag aaataaaaga agataatata ggtgctcaag tactagggtt atttacactt 900 tcaacagggc aagatagttg gaatcagacc aatggcggtg gccatcatca ccatcaccac 960 taa 963 <210> 29 <211> 963 <212> DNA <213> Streptococcus pyogenes <400> 29 atggatagtt tttctgctaa tcaagagatt agatattcgg aagtaacacc ttatcacgtt 60 acttccgttt ggaccaaagg agttactcct ccagcaaact tcactcaagg tgaagatgtt 120 tttcacgctc cttatgttgc taaccaagga tggtatgata ttaccaaaac attcaatgga 180 aaagacgatc ttctttgcgg ggctgccaca gcagggaata tgcttcactg gtggttcgat 240 caaaacaaag accaaattga acgttatttg gaagagcatc cagaaaagca aaaaataaac 300 ttccgtggcg aacagatgtt tgacgtaaaa gaagctatcg acactaaaaa ccaccagcta 360 gatagtaaat tatttgaata ttttaaagaa aaagctttcc cttatctatc tactaaacac 420 ctaggagttt tccctgatca tgtaattgat atgttcatta acggctaccg ccttagtcta 480 actaaccacg gtccaacgcc agtaaaaaaa ggtagtaaag atccccgagg tggtattttt 540 gacgccgtat ttacaagagg taaccaaagt aagctattga caagtcgtca tgattttaaa 600 gaaaaaaatc tcaaagaaat cagtgatctc attaaggaag agttaaccaa aggcaaggct 660 ctaggcctat cacacaccta cgctaacgta cgcatcaacc atgttataaa cctgtgggga 720 gctgactttg attctaacgg gaaccttaaa gctatttatg taacagactc tgatagtaat 780 gcatctattg gtatgaagaa atactttgtt ggtgttaatt ccgctggaaa agtagctatt 840 tctgctaaag aaataaaaga agataatata ggtgctcaag tactagggtt atttacactt 900 tcaacagggc aaaaaagttg gaatcagacc aatggcggtg gccatcatca ccatcaccac 960 taa 963 <210> 30 <211> 957 <212> DNA <213> Streptococcus pyogenes <400> 30 atggatagtt tttctgctaa tcaagagatt agatattcgg aagtaacacc ttatcacgtt 60 acttccgttt ggaccaaagg agttactcct ccagcaaact tcactcaagg tgaagatgtt 120 tttcacgctc cttatgttgc taaccaagga tggtatgata ttaccaaaac attcaatgga 180 aaagacgatc ttctttgcgg ggctgccaca gcagggaata tgcttcactg gtggttcgat 240 caaaacaaag accaaattaa acgttatttg gaagagcatc cagaaaagca aaaaataaac 300 ttcaatggcg aacagatgtt tgacgtaaaa gaagctatcg acactaaaaa ccaccagcta 360 gatagtaaat tatttgaata ttttaaagaa aaagctttcc cttatctatc tactaaacac 420 ctaggagttt tccctgatca tgtaattgat atgttcatta acggctaccg ccttagtcta 480 actaaccacg gtccaacgcc agtaaaagaa ggtagtaaag atccccgagg tggtattttt 540 gacgccgtat ttacaagagg tgatcaaagt aagctattga caagtcgtca tgattttaaa 600 gaaaaaaatc tcaaagaaat cagtgatctc attaagaaag agttaaccga aggcaaggct 660 ctaggcctat cacacaccta cgctaacgta cgcatcaacc atgttataaa cctgtgggga 720 gctgactttg attctaacgg gaaccttaaa gctatttatg taacagactc tgatagtaat 780 gcatctattg gtatgaagaa atactttgtt ggtgttaatt ccgctggaaa agtagctatt 840 tctgctaaag aaataaaaga agataatata ggtgctcaag tactagggtt atttacactt 900 tcaacagggc aagatagttg gggtggcggc ggtggccatc atcaccatca ccactaa 957 <210> 31 <211> 903 <212> DNA <213> Streptococcus pyogenes <400> 31 atgtccgttt ggaccaaagg agttactcct ccagcaaact tcactcaagg tgaagatgtt 60 tttcacgctc cttatgttgc taaccaagga tggtatgata ttaccaaaac attcaatgga 120 aaagacgatc ttctttgcgg ggctgccaca gcagggaata tgcttcactg gtggttcgat 180 caaaacaaag accaaattaa acgttatttg gaagagcatc cagaaaagca aaaaataaac 240 ttcaatggcg aacagatgtt tgacgtaaaa gaagctatcg acactaaaaa ccaccagcta 300 gatagtaaat tatttgaata ttttaaagaa aaagctttcc cttatctatc tactaaacac 360 ctaggagttt tccctgatca tgtaattgat atgttcatta acggctaccg ccttagtcta 420 actaaccacg gtccaacgcc agtaaaagaa ggtagtaaag atccccgagg tggtattttt 480 gacgccgtat ttacaagagg tgatcaaagt aagctattga caagtcgtca tgattttaaa 540 gaaaaaaatc tcaaagaaat cagtgatctc attaagaaag agttaaccga aggcaaggct 600 ctaggcctat cacacaccta cgctaacgta cgcatcaacc atgttataaa cctgtgggga 660 gctgactttg attctaacgg gaaccttaaa gctatttatg taacagactc tgatagtaat 720 gcatctattg gtatgaagaa atactttgtt ggtgttaatt ccgctggaaa agtagctatt 780 tctgctaaag aaataaaaga agataatata ggtgctcaag tactagggtt atttacactt 840 tcaacagggc aagatagttg gaatcagacc aatggcggtg gccatcatca ccatcaccac 900 taa 903 <210> 32 <211> 903 <212> DNA <213> Streptococcus pyogenes <400> 32 atgtccgttt ggaccaaagg agttactcct ccagcaaact tcactcaagg tgaagatgtt 60 tttcacgctc cttatgttgc taaccaagga tggtatgata ttaccaaaac attcaatgga 120 aaagacgatc ttctttgcgg ggctgccaca gcagggaata tgcttcactg gtggttcgat 180 caaaacaaag accaaattaa acgttatttg gaagagcatc cagaaaagca aaaaataaac 240 ttcaaaggcg aacagatgtt tgacgtaaaa gaagctatcg acactaaaaa ccaccagcta 300 gatagtaaat tatttgaata ttttaaagaa aaagctttcc cttatctatc tactaaacac 360 ctaggagttt tccctgatca tgtaattgat atgttcatta acggctaccg ccttagtcta 420 actaaccacg gtccaacgcc agtaaaagaa ggtagtaaag atccccgagg tggtattttt 480 gacgccgtat ttacaagagg taaccaaagt aagctattga caagtcgtca tgattttaaa 540 gaaaaaaatc tcaaagaaat cagtgatctc attaagaaag agttaaccga aggcaaggct 600 ctaggcctat cacacaccta cgctaacgta cgcatcaacc atgttataaa cctgtgggga 660 gctgactttg attctaacgg gaaccttaaa gctatttatg taacagactc tgatagtaat 720 gcatctattg gtatgaagaa atactttgtt ggtgttaatt ccgctggaaa agtagctatt 780 tctgctaaag aaataaaaga agataatata ggtgctcaag tactagggtt atttacactt 840 tcaacagggc aagatagttg gaatcagacc aatggcggtg gccatcatca ccatcaccac 900 taa 903 <210> 33 <211> 903 <212> DNA <213> Streptococcus pyogenes <400> 33 atgtccgttt ggaccaaagg agttactcct ccagcaaact tcactcaagg tgaagatgtt 60 tttcacgctc cttatgttgc taaccaagga tggtatgata ttaccaaaac attcaatgga 120 aaagacgatc ttctttgcgg ggctgccaca gcagggaata tgcttcactg gtggttcgat 180 caaaacaaag accaaattga acgttatttg gaagagcatc cagaaaagca aaaaataaac 240 ttcaaaggcg aacagatgtt tgacgtaaaa aaagctatcg acactaaaaa ccaccagcta 300 gatagtaaat tatttgaata ttttaaagaa aaagctttcc cttatctatc tactaaacac 360 ctaggagttt tccctgatca tgtaattgat atgttcatta acggctaccg ccttagtcta 420 actaaccacg gtccaacgcc agtaaaagaa ggtagtaaag atccccgagg tggtattttt 480 gacgccgtat ttacaagagg taaccaaagt aagctattga caagtcgtca tgattttaaa 540 gaaaaaaatc tcaaagaaat cagtgatctc attaaggaag agttaaccaa aggcaaggct 600 ctaggcctat cacacaccta cgctaacgta cgcatcaacc atgttataaa cctgtgggga 660 gctgactttg attctaacgg gaaccttaaa gctatttatg taacagactc tgatagtaat 720 gcatctattg gtatgaagaa atactttgtt ggtgttaatt ccgctggaaa agtagctatt 780 tctgctaaag aaataaaaga agataatata ggtgctcaag tactagggtt atttacactt 840 tcaacagggc aaaaaagttg gaatcagacc aatggcggtg gccatcatca ccatcaccac 900 taa 903 <210> 34 <211> 963 <212> DNA <213> Streptococcus pyogenes <400> 34 atggacgatt accaaaggaa tgctacggaa gcttatgcca aagaagtacc acatcagatc 60 acttccgttt ggaccaaagg agttactcct ccagcaaact tcactcaagg tgaagatgtt 120 tttcacgctc cttatgttgc taaccaagga tggtatgata ttaccaaaac attcaatgga 180 aaagacgatc ttctttgcgg ggctgccaca gcagggaata tgcttcactg gtggttcgat 240 caaaacaaag accaaattga acgttatttg gaagagcatc cagaaaagca aaaaataaac 300 ttcaaaggcg aacagatgtt tgacgtaaaa aaagctatcg acactaaaaa ccaccagcta 360 gatagtaaat tatttgaata ttttaaagaa aaagctttcc cttatctatc tactaaacac 420 ctaggagttt tccctgatca tgtaattgat atgttcatta acggctaccg ccttagtcta 480 actaaccacg gtccaacgcc agtaaaagaa ggtagtaaag atccccgagg tggtattttt 540 gacgccgtat ttacaagagg taaccaaagt aagctattga caagtcgtca tgattttaaa 600 gaaaaaaatc tcaaagaaat cagtgatctc attaaggaag agttaaccaa aggcaaggct 660 ctaggcctat cacacaccta cgctaacgta cgcatcaacc atgttataaa cctgtgggga 720 gctgactttg attctaacgg gaaccttaaa gctatttatg taacagactc tgatagtaat 780 gcatctattg gtatgaagaa atactttgtt ggtgttaatt ccgctggaaa agtagctatt 840 tctgctaaag aaataaaaga agataatata ggtgctcaag tactagggtt atttacactt 900 tcaacagggc aaaaaagttg gaatcagacc aatggcggtg gccatcatca ccatcaccac 960 taa 963 <210> 35 <211> 19 <212> PRT <213> Streptococcus pyogenes <400> 35 Ser Phe Ser Ala Asn Gln Glu Ile Arg Tyr Ser Glu Val Thr Pro Tyr 1 5 10 15 His Val Thr <210> 36 <211> 19 <212> PRT <213> Streptococcus pyogenes <400> 36 Asp Tyr Gln Arg Asn Ala Thr Glu Ala Tyr Ala Lys Glu Val Pro His 1 5 10 15 Gln Ile Thr <210> 37 <211> 20 <212> PRT <213> Streptococcus pyogenes <400> 37 Asp Asp Tyr Gln Arg Asn Ala Thr Glu Ala Tyr Ala Lys Glu Val Pro 1 5 10 15 His Gln Ile Thr 20