Listado de secuencias <110> Shenyang Tonglian Group Co., Ltd. <120> Agrupación de genes biosintéticos de carrimicina <160> 46 <210> 1 <211> 89315 <212> ADN <213> Streptomyces spiramyceticus WSJ-1£© <400> 1 gtggagagcc gagggggcga cgaggccgac tatgccgcgc tccatcccga ggaagaggcg 60 gtggtggcac aggcggtgga caaacggcgc cgcgagttca ccgcggtgcg cgcctgcgcc 120 cgccgggcca tggagaagct cggcttcccg ccgcagccca tcctgccgag tgagcgcggc 180 gccccgcgtt ggccggaggg cctgctcggc agcatgaccc actgcgacgg ttaccgcgcc 240 gccgccctcg tccgcgccac cgacctggcc tccctcggca tcgatgccga accgcacggt 300 tcgctcccgg acggcgccct gcattccgtg gcgctccccg ccgagcggga gcgcctggcc 360 ctcctcgccg ccgggcagcc cggcgtccac tgggaccggc tgctgttcag cgcgaaggag 420 tccgtctaca aggcgtggtt cccgctgacc gggaagtggc tgggcttcga ggaggcgtac 480 atcgatctcc accaggattc cggaacggcg cagcacggcc gcttccgcgc cgaactgctc 540 gtccccggac cgctggtggg gggacgaagg atcaagcatt tcgaggggcg gtggatcgtc 600 cgcgagggcc tggtcaccac cgcattgacg gtcccccacc cctgatcccc ctcgcgcgcc 660 cgaaagccgg ctccgggtgg ggccagcccc gccgcccgcg gggcgtagcg ggattccggc 720 acggaccgtg cgaccgtacg ttcttccata gtggtcgggt acatccattc ccggctggca 780 gaacgacgtc gcccgcaccc agatctggca gtggctgcgc cacgggtcac cgaccgcgcg 840 acggtcctgg accttctgga cgcggaggtc gcggcgctgg gcgcggagta cccctggggc 900 ccggtggacg aggcccgcga cctcttggaa cgtaccgctc tggcacggga cttgccggac 960 ttcttcgcct cggtcggcta cgccctcacc tggtggagca cccctaccac cggggctgag 1020 gggccccggt ggcgccgccg gggccgaggg gcgcggcggc tgtggtcgag cagggcgcgg 1080 tacgggttgg tggatccgta ccgcgcctgc ttcgccttcc ccgtacgagc cgtcaccacg 1140 agcaccaccg acgaccgcgg gcaccgtcgg cgtcggcatc ggcatcggct caaccgcgtc 1200 tccggcctca gcgcggcgcc aggccgcgga gcgcgaggtc gacgagggcg tcggtgtatt 1260 cgtgcgtgag gggcccgtcg cccatcagcc agtgctgggc gacgggcccg gccagcatca 1320 gcacagcgat ccgcggatcg acgtcctgcg cgatctgacc ggccccccgg gcagagccca 1380 agcgctccag gcagagccgt aacgggggct ccaccaggcg cgccgtcagc tccttgccga 1440 gcgcagggtc ggctatgccc gcggcgacga gggcgcgggc gggcacgtcg taccccgggt 1500 cggtcatggt gtcgacagcg gaccggagaa cggccttgag atcggcctcc agatcgccgg 1560 tgtcgcggac agcgcccccg gcccgcgcga tgtcctcggt cagggagacg accgcgtccc 1620 ggaggatggc cgccttggag ggccaccggc ggtagatggt ctgtttgccg acgcctgccc 1680 tggcagcgac cccttcgatg gtcactctgg gatatccgac ctcgtgaacg agttccagcg 1740 tggcgcccag gatcgcacgg tgtgcgcggc gactgcggtg ggcggtttca ggtgcgcggt 1800 gggaggacat ggtccacagc atagacctcg acgaaccgat acgtatcgtc ttgacaagac 1860 gatacgtatc gtcgaagctc atggatgtac cgagacgcaa cgcctcggct caccgacgac 1920 aggagaagcc catggccaag ggagcaaaga agatgctggg cctcggcggc acccgctcga 1980 acctctcccg cagcgcgatg cgcggcggga actcgggcgg aattcccggc ggcggcatca 2040 gcccgcagga gcagaagcgg gagctgctgc gcaaactcaa ggaagcgcgg tccaccaagc 2100 agaccccctc gtcgtgaagg cctccacctg aggggaccgg ctgcgtatgg gctttcgtac 2160 gcagccggtt ccccctcccc gaggtccaca ggtccgagcg tccacaggtc cgggctgcgg 2220 gaacgccggc ccccggaata cgggctccga agtgccggaa ctcggagagc gggcccacga 2280 agcatcagca gtcggccgtc cgttggtgtg cgcggaacag cgcggtccac tccgggaccg 2340 tgaggtcctt gacccgatcg gcgggccgca cccccgcgcc gcgcacgaac tgggcgtgtc 2400 cgcggcgcag cacctttcgc gcggcctcgc ctatcgtcat ctggccggtg tcgaagacct 2460 gctgggtgaa ccgctgatag gcggtgcgct cacgccaggg cacgggcggc ttgcgatggg 2520 gggtcaccat caatgtctgg gtatcggcgc gcggcacggg gttgaactcc tgtcgcgaga 2580 aggccagccc tttctcaaac gcgtaccacg gctcccactg ggcgttgaag agatttccgc 2640 cccaggctcc ggtccgcttt cccacatact cgcgctgaag caggaacacg ccctggcgca 2700 tccggtccgg acccaactcc aggcaacgtc tcagtatctt ggtgccggag acaaagggca 2760 gattgccaat caaccggacc ggctgccctg gcaattgcag tgtcagaaag tcctcgttca 2820 ccaccgtgac atcgggcagc gattcggcgg ccagccgacg ggcccattgg gtgtcgattt 2880 ccaccgcgag taagggactt ccggtcgatg cgagcgcttt ggtcacccgg ccggatcccg 2940 cgcctatctc gacggtcaga aggtcattcg gcgaaccggg cgcgatggca tccgagctgt 3000 ccagctgagc ggagaacctg caggctgcag cggctgcccg gaagaaattc tgaccccatt 3060 ccctccgcgc gacgcagcgc gacgcagcgg gagcggaggc ggatcgcggc ggccgtgggg 3120 atttcgattt cacccgggcg acattaccaa cccctcaccc aatgatccat caacaaccgg 3180 tatgcccaac ggaattcggc catcctcgga cccgatcacg acatcggccg acgagccctt 3240 cgggaccgac tggtgactgc cgtgcgaacc ggcattgtcg gcgaatcatc cggacgatcc 3300 acgaattccg gggcattcga gcccggcccg gcgcgttacg gcccggcgcc tgtccgggcc 3360 gtaacggtgt tcccacgggc tcatggtgat tcaccacagt ctcgactgcg acggccaacg 3420 ccgtgagccg aacgggaatg aatcctggcc gacttcgtca ggttcaacgg gcgccgggcc 3480 ggcgcggccg gtggccgctg actgtgtcat ctccatgttg tcggccgaac gcaccgcgcc 3540 ccaggatgac ccagcccatt ccctgcggtc accccggcca cagtccccat cccgaaagag 3600 gagcgagaat ccagtgctcc atcgcgtcga tctgtcgtcg ctcaccggcc tccgctggta 3660 cgcggcgttg acagtattcg cctgccacat cgcccagcag ggcttcttcg ccgaccagca 3720 ggtcggcagc gcactgctgc acatcaccac gctcggctcg atggcggtct cggtcttctt 3780 catactgagt ggcttcgttc tggcgtggtc ggcccgcgac gaggactcca ccccgacttt 3840 ctggcggcgc cgcatcgcga agatctatcc gctgcacatc gtcacgttcg gcattgcggc 3900 cctgatcatc ttctccctct cggaaccggt ccttcccggt ggctccgtgt gggacggcct 3960 ggtgcccaat atcctgctgg tgcagtcctg gcttcccgac gcgtcccttg cggccagttt 4020 caacacgccg agctggtcgc tctcctgtga actcgccttc tatctgtcgt tcccgctgtg 4080 gtatcggctg gtgcggaaga ttccggtggg gcgactgtgg tggtgcgccg ccgggatcgc 4140 cacggccgtg atgtgtgtgc cgttcgtgac gggcctgctc ccggcgagcg aggaggcggc 4200 ccccgggatg ccgctcaacg aggtgtggtt cgcgtactgg ctgccgccgg tgcggatgct 4260 ggaattcgtc ctcggcatcg tgatggcgct gatcctgcgc gcaggcgtgt ggcggggccc 4320 acgggcgggg acctgcacgc tgctgctcgc cgcgagttac ggcctcaccc aggtggtgcc 4380 cccgatgttc actctcgccg cgtgctccat cgtgcccgcc gccctgctga tcaccgccct 4440 ggccgacgcc gatgtgcacg gtcggcgcac ggggctgcgc tccgcgatgc tggtgcggct 4500 gggccagtgg tccttcgcct tctatctggt ccatttcatg gtcatccgct acggacaccg 4560 actgatgggc ggcgagtcgg gatacgagcg ccagtggagc accccggccg cgatcgctct 4620 gtccctggcg atgctgatgg tcgcgatcct ggtcggcggg ctgctgcaca ccgtcgtcga 4680 gcagccctgc atgcgactgt tcggcagccg cacgccctcc gccgtcccga agcccggcac 4740 cgcccctgcg ccccgaagtt cgcccggccc cgacgtcacg ggcgtaccag tcgtcacgca 4800 cacgcccgac gtgacgaacg agctctcccc gaaaggatga tgagcgtggc agaccagacc 4860 gctctcagcc cagcgctgct ggaatacgcc cggagcgtcg cgctgcggga cgacggcctg 4920 ctgcgtgaac tgcacggggt aaccgcgggg cttcccgggg gccgggccat gcagatcatg 4980 cccgaggagg cacagttcct cgccctgctg atccggctcg tcggcgcccg gcgcgtgctg 5040 gagatcggca cgttcaccgg ctacagcacg ctgtgcatgg cgcgagcact gcccgccgac 5100 ggcagaatcg tcacctgtga catcagcgac aagtggcccg gcgtgggcgc cccgttctgg 5160 cggcgggccg gggtggactc cctgatcgac ctgcgcgtcg gcgacgccgc ccgaaccctc 5220 gccgagctgc gcgagcacga gggggacggc gtgttcgacc tggtcttcgt cgacgccgac 5280 aagaccgggt acccgcacta ctacgagcag gcgctggcgc tggtccgccc cggcgggctg 5340 gtggcgatcg acaacacgct gttcttcggc cgggtggccg atcccgccgt cgacgacgcc 5400 gacaccgtcg ccgtgcgcag gctcaacgac ctgctgcgcg acgacgaacg cgtggacatc 5460 gcgttgctga cgatcgccga cgggatcacg ctggcccgcc gacgggagtg agatcgcacg 5520 gcgtggggcg cagacgcaac gtcgtgaacg acggcggatt cgcgccaacg cccgcctgtg 5580 caaagcgact tcgcgacgtc tccgggacgc tgctggaatc ggctgccgcc gccggcctgc 5640 tacgacaggc cggcggcggc agcgtgtgcg gacctcgtgc ggtggccccg taccgcgacg 5700 aggggcccct gcaccggaag cagcacggca agcgtccgca cgccctcgga cgcatccgag 5760 ggcgtgcacc gggaacgccc cggagggccc gcccgaccgg tcagcggaac cggttgatgg 5820 cgtcgatgtg cttcgcgcgc ttctcctcgt cgcgcacgcc cagcccctcc gtcggggcca 5880 ggcacagcac gccgaccttg ccctgatgga ggttgctgtg cacgtcgtgc acggcgagcg 5940 cggtgtcggc cagcgggtag gtgcaggaga gcgtggggtg gatcttcccc ttggcgacga 6000 gtcggttcgc ctcccacgcc tcgcggtagt tggcgaagtg ggttccgacg atgcgcttga 6060 ggtgcatcca caggtagcgg ttgtcgaact cgtggcggaa gcccgaggtg gaggcgcacg 6120 tgacgatcgt gccgcccctg cgggtgacgt agacggacgc cccgaaggtc tcccggccgg 6180 ggtgttcgaa gacgatgtcg acgtcctcgc cgccggtcag ctccctgatg cggccgccga 6240 accgcttcca ctcccgcggg ttctgggtgt cctcgtcggt ccagaagcgg tagtcctcgg 6300 cggagcggtc gatgatggcc tcagcgccca tggcccggca cacctgagcc ttgcgctcgc 6360 tggagaccac gcagacggga ttggccccgc cggcgagggc gagctgggtg gcgtacgagc 6420 ccagaccacc gctggcgccc cagatcagca cgttgtcgcc ctgcttcatg ccggcgccgt 6480 tgcgggagac cagctgacgg tacgcggtgg agttgaccag accgggcgcg gccgcctcct 6540 cccaggtgag gtgggctgcc ttgggcatca gctggttgga cttgacgagg gccacctcgg 6600 ccaggccccc gaagttggtc tcgaagcccc agatccgctg ggccgggtcg agcatggtgt 6660 cgtcgtgccc gtcggcgctc tccaactcca ccgacagaca gtgcgccacg acctcgtcgc 6720 cgggcttcca gacgttcacc ccggggcccg tgcgcagcac cacgccggcc aggtcggagc 6780 cgaggatgtg gtagggcagg tcgtggcggg cggccgacgg cgatgtgcgg ccgtagcgct 6840 ccaggaagcc gaaggtcggc agcggctcga agatggacga ccagaccgtg ttgtagttga 6900 cggagctggc catcaccgcg atcagtgcct cgccgggccc cagttcgggc agcggcacct 6960 cgtcgacgcg cagcgacttg cgcgggtcct tgtccgtgct cgtcatgccg cggaacatgt 7020 cggtgtcctc tttgcggacg gtcacggccc ggaaggactc gggcaggcgc agcgccgcga 7080 tgtcctcggg ggtgcggtcc ggcgcggtga tcgcggcgag cagcgcgctc tgggcatggc 7140 tttcgggcat gggggacgga ctccgttcga tcgtttcgtc aggtcgcccg gtgcagggcg 7200 gtgaggcgct ccagggtggg gacgatcccg gcaggcgtgg ggtcggcgag catctcctcg 7260 ctgagccgcc gcgcgcctgc tttgatcgcg gggtcgtgca cggccgtgtg caccgcgtcg 7320 gccaggccgc gtgccgtgag ggtcgcggcg ggcaggtcga acccggcgga gaggcgctgg 7380 agttgctggg ccttgagcgg cgcgtcccac agcgagggca gcaggatctg cggcactccg 7440 tggagcaggg cggtggacca ggtgcccgct ccgccgtgat ggatgatcgc ggcgcagctc 7500 ggcagcagcg cgtcgagcgg cacgaagtcc accggtacga cgttgtcggg aaggacgccg 7560 aggcgctcgc gctgggaggc gtcgagggtg gccaccacct cgatgtccag ccgtcccagc 7620 gcctccagca gttcggagta ggagaccgcg tcgcggccgt aggtctcgcg ggcagacacc 7680 ccgagggtga ggcagacgcg ggggcgatcg ggcttcttgg cgagccaggg ttcgatcacg 7740 gagcgcccgt tgtagggcac atagcacatg ggcaccatgg tctgccccag gtcgagccgg 7800 gtgctgcggg gccccgggtc gatcacccag tggccgagca cgtcgcgttc gtcgaaggcg 7860 tacccgtatc ggtcgagcgt ccagccgagc cattcggcga tggggtcctc gcgcagttcc 7920 tccggtacct gctcgagcgc tgcgaggaag cgccggcggg agcgtccgat ggcatcgggg 7980 ccccagagga tgcgggcgtg ggcggcgccg caggcgcggg ccgcgaccgg ccccgcgtag 8040 gtccagggtt cccagacgac caggtcgggg cgccagccac gggcgaaatc gacgatctcg 8100 tccatcgtgg cggcgccgtt gaacggggcg aagcacaggg cggccatcat gctctgctgg 8160 ccgagcagat actcccaggt ggtctcctcc tcgctctcca cctcgccgaa ctcgaagccc 8220 cgctggtagg ggacgaggtc gctgcccatc tcggcgagca gctccgcggc gggtcggtcg 8280 tcgccgacgg ggacggcggt caggccggtg gaggtgatga cgtcggtgag cgagggcggg 8340 ctcgccaccc gtacctcgtg cccggctgcg cgcagcgccc aggccagggg caccaggctg 8400 tagtagtggg tgttgtgggc gagggaggtc agcaggacgc gcacggtgac tccggtctgg 8460 gacgggggtg tacgggcggg gtcatcccgg gtggacccgg aggcgggcgc aggcgcctac 8520 gaccggggaa cgcggccggg tcagcggcgc gccctcggcc cgcagtccgg gcaggcggcc 8580 ggccatgacc tggaccgcgg tggtggtggc caggcggatg agcgggaggg cgagcgccag 8640 gtgcggcccg tccgggccgc cgagcggctc cggccccggg gtctcccgtc cggcggcggc 8700 cagcaccaca atgtgctcgt cggcggcgat ccggcggccg ccgagttcga ggtcggtgtg 8760 cgcgaccctg ctctccagcc gggccggggg gcggtggcgc agcgtctgct cgacggccct 8820 cgcggcggcc ggggtccggc gggccctttc ccactccccc ggccggccca gcagccggtg 8880 caccgtgtgc gcgacggcgg tggcggccgg ctcgggggcg ccgatggcga ggaccagcgc 8940 gatgcgctcg acgtcgcggg gtgcgacgcc atcgcgcagg aggagggcga ggacgtcgtc 9000 gggccggggc ccgccgctct cgacggcccg cagcttctcc gcgacgagct ccgggaccag 9060 gtcggccagg gtccgcacgg cgtcggcgga ctcccgggcg acggccagga tctgcggggc 9120 cagccgggcg tcgagctggg gggcgcaggc ggcgagcgcc cgcgcggcgg cgtcgcggtc 9180 gcggtccggc actccgagga acccgagcac cagctcgacg gcgtacggcc gggcgacctc 9240 ggtgacgagg tcgaacccgg cgccaccggt tggcaggaga cggcggagca ctcggcgggc 9300 ggtggtgcgc gccgcgcagg gcgcctcggc cggggcgcaa cggttgagta cggggtcggc 9360 cagcgcccgc aggcgtacga gctccgcgcg ttcgtggcgg gggaacgcct cggcgagggg 9420 cagcagttcc tcgtccggac ggcggccggc ccggtccagc gtgccgaaac gtgggtcggc 9480 caggacagcc gccgccacct ctgggtccgc ggtcacccag gcgcccagca gttcgctgtg 9540 gaaccacggt ccggcggcgc agatttcccg ttcgagcggc tcggggtcgg agacggcgcg 9600 cagaatcagc gcgtacgggt cgccctgatt gcccgcgcac cagtgcgcgg cacgggtcag 9660 ctgaagccga cggccgagct cccgggtgcc cgcgctcgcg ggagccggct ccatggcaag 9720 gatgggcatg gcttcctctc gtcatctcgg atggcacgaa gtcggacggt acgaaggggg 9780 tggcgaaggc gtgtcgccac ggggaggtcc gcctcggcgg cgggcagctt cagcggcggg 9840 tgccgatgaa cagtccgcgg ccggaggggc cgccctcctg gtagaccacg tcgcagccgg 9900 cgcgctcgaa ggcggcttcg tagtcggcgc gcgggaacag ggtgatggcg tggtcctcgg 9960 tgaggtgacg gatgccgccg ccgggctcgg cgacgaggta gtgcacctcg atgcgggtgg 10020 cgttcccctc ccgcacagaa tgcgagaccc ggcagatggt gcgctcgccc gcctcggtga 10080 cgctggcgcc gacgtagccg ggggtgaagg agctggggaa ccaccagggt tcgacgacga 10140 tgacgccgcc cggttcgagg tggtcggtga aggaccgcag cgtgctgtcg agttcgtccg 10200 tggtccgcag gtggcctatg gagctgaaca tgcagatcac cgcgtcgaac cggcggccca 10260 gggcgaacga gcgcatgtct ccttcgtgga aggtgacgcc ggggttgcgg tcggtcgcga 10320 gggccagcat gtcgtgggag agctccaggc cctcgacgtg gtcgaagagg ccgtcgaggt 10380 ggcgcaggtg ctggccggtg ccgcaggcga cgtcgagcag tgaccgggtg tccgggcggt 10440 ggacgcgcac cagtgcggcg atctcctcgg cctcctgccg gtagtccttg cccttcccct 10500 cgtggaccag gtcgtagacg gccgcgatgt cgttggcgta catcagtgtt ctcctccggt 10560 gagcagggcg ggcggcccgg ccgggtgcgg gacggcctcc agccagtcgt gcaccacgga 10620 cgcggtgtgc cgcgcgtgtt cggtgagcat ggtgaagtgg ttgccgggca cgtcggcgac 10680 ggtccgggcg aacgggaccc gggagcgcca gtcgccctgt gcctcgccga cgggccactc 10740 gcgcaggggt tcggacgccc ggacgagcag gacgggggcg ttcagggcgg tgagccgggc 10800 gccgagcagc agccggtggt agccggccat ggcggtgagc cggtggtcct ccagggggac 10860 ggtgctgcgt tcgagggccc ggctgagcag gtcgtcgcgc cacacgccca tcgcgccggg 10920 gtcctcggga cggtagacgt ccatcagcac gacggccgtg gggccggtgc cgcgctcctc 10980 caggcgggcg gccagggcat gggcgacgtt cgcgccggcg gagtgaccgg cgagcgcgaa 11040 cggcttgccc gcggcgtgct ccaggaggac gtcggcctgg acgtcgagca gggcgtcgag 11100 ggatgcgggc agcggctccg cggggccgcc gaaaccggac agggggagaa cgaccgtctc 11160 ccggctgtcg cgcagccctt cggcgaaggg gacgtactcg ccggggccgg agccgaccgc 11220 ggtgccggcg cagcagtaca gcgtggggtg cgtcgtcggg ccggtcgcga ggagcaccgg 11280 cgcggggcgg gcggagccgg gctgttcccg ggagtaggcg ggccggaacg cggccaggga 11340 ggccatcagc tccacggcct cgcccgacct gctctgttcg acggcggcgc ggaaggaggc 11400 gagcagcccg ctctcggccg gtacggcgct ctcgtgacgg ccggtggccc cggcgtcagc 11460 gaggccggcc aggtggtgtg ccagtgcggt gggatcctcg tggtcgaaga cgagggtgct 11520 gggcaggtcg agcccggtgt cctcggccag tcggccgcgc agccgcaccg cggccagcga 11580 gtcgaagccg atgtcccgga agggggcctg tgcgtcgccc cggttctcct cggtgtggcc 11640 gaggaccgct gcgatgtggc ggagcaccag ttccagggcg agccgcggcc ggtcctcggg 11700 ccgcgcccgt acgaggtcgg gtgcggtggg ggtgtcgtcg gcgggctgcc cggcggcggc 11760 gagcgccgta cgggcgacgg ggatgccgga gatcaggggg ctggggcgga aggcggtgaa 11820 gccgggggcg aaccgttccc agtcgaggtc ggccacggtc accgtggcgt cgccgctgtc 11880 gacggcctgg tgcagggcgg tgagcgccgt ctccgggcgg aggggaacaa ggccatggcg 11940 ggcgaggtat ccctcggggg ccatctcgcc catgccgccg ccgtcccaga cgccccaggc 12000 gacggaggtg gcgggacggc cctgcgcacg acgccgctcc gccaacgcgt ccaaatgcgc 12060 attggccgcc gcatacaccg actgcccccc actcccccac accgccgcac ccgacgagaa 12120 caacacgaac acatccagat ccacacccgc cgtcaactcg tccagcaact cagcccccac 12180 cgccttaccc gccaacaccc ccgcagcctc cgccaacgac acctcaccca acgccgacac 12240 ctgagccaca cccgccgcat gaaacacccc acacaacggc acccccaacc cctccaccac 12300 acccaacaac cccaccaccg acgcacgatc cgccacatca cacgcaacga acgtcacctt 12360 cgcccccaac cccaccaact cccgctccaa ctccaccgcc cccggcgccc caccaccacg 12420 ccgacccgcc agcaccacat gctccgcacc cccacgcgcc aaccaccgcg ccacatgacc 12480 acccacacca cccaacccac ccgtcaccaa cacacacccc cgcggccgcc acgacctcga 12540 ggccgagggc acagcggcag gcagcaggcg gcggccgaac aaccccgacc cgcgaatcgc 12600 cacctggtcc tcaccgccgc ggccggagac gacagcggcc agacgccgcc agtcacgccc 12660 gcccggctcg gccggcagat ccaccagacc gccccactgc acaggcgcct ccaacgccgc 12720 cacccgccca agcccccaca cacgcgcacc catcgcacac ggcacctcac ccggcccgac 12780 cgccaccgca ccccgagtgg ccacccacag cggtgtctcc accgcggcat ccgccatcgc 12840 ctgcaccatc agcagcaccg ccgtcgtccc ctcgtccagc cccgggtgcc cggcgagcgt 12900 ggctccgccc gtgtcgggga gcagcagcac gccggccaag ctctccgggc tccgcgcgag 12960 ttcggccagc cgagcagcca gggcgtcccg gtccagtgcg tccgtccgcg gcgctccggc 13020 ggcctgcccg agcggccgca ccaggcggat cacttccgcg ccggccgcgc gcagcgcccg 13080 ctccgcggcg tccgcggagt ccgtgcactg cccatgctcg accatcagcc agcgatccga 13140 ggggctgaac ctgacagcgt ctggggcgat cgcctgccag gcgacgcggt agcgcagccc 13200 tgcggtctgc gcggtcgtgc ggcgccggtc gtgccaggcg gctaagtgcg gtaggacggc 13260 ctgcagttgg ctttcgattc ccgcaccgtc ggcgcccagt cgcgccgcgg ccgaggcagc 13320 gtcgcccgcg tgcaccgcgg cccacagggc gtcgtcctgc tctgcttccg cgacgggccc 13380 tgcggagggg gcggaggtcg cgggggcgac cgtgggcgag gcggcggtgg gggcgagcca 13440 gtagcggctg tgctggaagg cgtaggtggg caggtcggtc cggcgtgcgc ccgtaccgct 13500 gtagagcgcg gaccagtcga ggtccgcgcc gcgaacgaac gccctcgcag cggcccggag 13560 cgcggtgtcg ccctccggtc gcccgcggcg cagcgcgggg gcgaacacgg tgtcggcctc 13620 gtcggccagt gactcctccg ccatgccgga gaggactgcg tcggggccga gctcgatgaa 13680 ggtcgtggcg tcacgggccc gcgcggtgcg cactgcgtcg gcgaaacgca ccggctcccg 13740 cacctggcgg gtccagtagc cagggtccct cagctgggcg gcggtggcga gttcgccggt 13800 cacttcggag acgaccggca gccggggagc gtggtagtcg accgtttcgg cgatcacgcg 13860 gaagtcggcg agcatggcgt ccatgcgcgg cgagtggaag gcgtggctca cccgcaggcg 13920 cttggtacgg cggccccggg cggccagttc accggccgcc gccagtacgg ccgcttcgtc 13980 cccggaaagc acgagggcct gcggtccgtt gaccgcagcg atgaccgcgc caccggcgac 14040 gacgggctcc agcgcggcga cctcccgctc ggtggcctgc acggcggcca tcgcgccgcc 14100 ctcgggcagg gcccgcatca gccggccgcg tgccgcgacc agccgggcgg cgtcggccgc 14160 cgagaacact cccgccgcgt gagccgccac caggccgccg atcgagtgcc ccacgaggac 14220 gtccggcacc aggccccagc tctcgaagag ccggaacagt gcggtctcga ccgcgaacag 14280 ggcgggctgg gtgtagtcgg tacggtcgag cagtgtggcg tccggcgcgg agggttcggc 14340 gaacatcacc gacagcaaag ggcgttcgag gtgggcgtcg aactccgccg cgatctcgtc 14400 gagggcgtcg gcgaagacgg ggaacctcct gcggagctcc tgaccggcgc cgagccgctg 14460 ggcgccctga ccggaacaga ggaaggcgat cccgcggccg cgccgcgcga cgcctgtgac 14520 catgttctcc ggcgtccggc cggcggccag cgcggcgagg tcctcccggg ccgcccgggc 14580 gtcgtgcacc agcgcaaccg cccggtgttc cagggcttcc ctggtggtgg ccagggagta 14640 tccgaggtcg acggcagtgg tgagatcggc gtcggtgtcc tccgtgggcc cccggcgggc 14700 gagggcggcg agccggtcgg cctggccacg cagtgcctcc tccgagcggg cggagatcac 14760 ccagggaagg ggggtcgcgg ccgtgatgcg ggggtcaggg gcgggcccgt cgctgccgtc 14820 ggcctcactc ggaggttcct cgatgacgac atgggcgttc gtcccactga cgccgaaggc 14880 agagacagcc gcccgacgca cccggcccgc ccgccggggc caggaccggg cctcggtcag 14940 caactccacc gaccccgaac cccactcgac cttcgacgac ggagcatcca catgaagagt 15000 gcgaggcaac gacgaatgcc gcatcgcctc caccatcttg atcacaccac ccacacccgc 15060 agcggcctga gcatgcccga tgttcgactt caacgacccc aaccacaacg gatcacccac 15120 ccgctcacgc ccatacgtcg ccagcaacgc acccgcctcg atcggatccc ccaacgccgt 15180 acccgtgcca tgcgcctcca ccgcatccac atcccccggc gccagcccgg catcagccaa 15240 cgcctcacgg atcaccctcc gctgggccgg accactgggc gccgtcagac cgttactcgc 15300 accatcctga ttgaccgcac tcccccgcac caccgccagc acccgatgcc cataccgacg 15360 agcatccgac aaccgctcca ccaacaacac accaacaccc tcggcccaca cagtgccgtc 15420 cgcaccctcc gcaaacgcct tgcaccgccc gtccgacgcc agcccacgct gccgggagaa 15480 ctccacgaac accgtcgggt cgggcatgac cgctacgccc ccggccagcg cgagatcgca 15540 ctcgccccgc cgcagcgact gcaccgccag atgcaatgcc accaacgacg acgagcaggc 15600 cgtctcgatc gtcagcgccg ggccctccag gcccagggtg taggcgatac ggcccgacat 15660 caccgcgtcg gcgttgcccg tcagcagata gccctcggtg ccctcgggcg cccgcgcggt 15720 gtcggcgacg tatccggtgt gtgcggctcc gacgaacaca ccggtacggc tgccgcgcag 15780 cgacgcgggg acgaccccgg cccgctccag cgcctcccag gacgtctcca acagcagtcg 15840 ctgctgcggg tccatcacca gcgcctcgtt cggcgagacg ccgaagaagg cggcgtcgaa 15900 gtcgccgacg ccggtgagga agccgccctc gcggcagtag gtagtgccgg gcgtgtcggg 15960 gtcgggcgag tagacggcgg cttcgtccca gccgcggtcg gcggggaagc gggtgatcgc 16020 gtcgacgccg tccgcggcga gctcccacag gtcgtcgggg gtggtcacgc cgccggggta 16080 gcggcatgcc atgcccacga tcgcgacggg ctcgtgcgcg gcggccagga gctctcggtt 16140 gtgtcgacgc agccgctcgg tctccttgac cgaggtgcgc agcgcaccca gcacttcgtc 16200 catggacggt gacatcttcg gcttcctcgt ctgctcgctg tggggggcgt cggtggtacg 16260 gcgcactgcc ggtccgcacg cacccggtac gggccgctac cggccggcac acaccggtac 16320 gggggggtta ctgctctggt gctccgccgc gggtggtccc cgcttcggtg gacccgtcgt 16380 tcgccggcgc gccgtcggcc ggtccggtgc cgcccgtcgc cagccggacg agggcatccg 16440 cgtcgagctc gtcgatctcg gcgtcgtggg cagccggctc cggtgcgggt ggcgacgcgt 16500 cgttcccgcc tgtgccggcc gggcccggcg cgccgccccg ttcggggtcg ctcgcgccgg 16560 tcagctcctc cagcagcgcg ttgccgagcc ggtcaacggt ggggtggtcg aagatgatcg 16620 tcgcgggcag cacgagcccg gtcgcctcgg ccagccggcc gcgcacccgc accgcggcca 16680 gcgagtcgaa gccgagttcc ttgaaggcga cgtcgtggcc gatacggccg atcccgtcgt 16740 ggcccaggac ctctgccgcc accgtgcgga ccaggtcgac cagcaccttc gtgcgctcgc 16800 gcggggtgag tgcggcgtcg atgcggcggc gcagatcgtc cgacgcgccg acggtgggct 16860 gggccgcccg cagcgcgcgg acctggggga tgccggagat cagggggctg ggccggaagg 16920 cggtgaaccc ggtgacgaag tgctcccagt cgatgtcggc gaccgtgaca caggtgtcgt 16980 cctggttcag cgccgtgtgc agggcctcaa tgcccgactc cggtcgcatc ggggcgagtc 17040 cgcgctcggt gtagaagtcc ctgacgccgt cgcccgcgcc catgccgccg ccgtcccaca 17100 ggccccaggc gacggaggtg gcgggacggc cctgcgcacg acgccgctcc gccaacgcgt 17160 ccaaatgcgc attggccgcc gcatacaccg actgcccccc actcccccac accgccgcac 17220 ccgacgagaa caacacgaac acatccagat ccacacccgc cgtcaactcg tccagcaact 17280 cagcccccac cgccttaccc gccaacaccc ccgcagcctc cgccaacgac acctcaccca 17340 acgccgacac ctgagccaca cccgccgcat gaaacacccc acacaacggc acccccaacc 17400 cctccaccac acccaacaac cccaccaccg acgcacgatc cgccacatca cacgcaacga 17460 acgtcacctt cgcccccaaa cccaccaact cccgctccaa ctccaccgcc cccggcgccc 17520 caccaccacg ccgccccgcc agcaccacat gctccgcacc cccacgcgcc aaccaccgcg 17580 ccacatgacc acccacacca cccaacccac ccgtcaccaa cacacacccc cgcggccgcc 17640 acgaacgccg cctcacacca ggcgcagccg gcagcatgcg gcggccgaac agcccggatc 17700 cgcgaatcgc cacctggtcc tcaccgccgc ggccggagac gacagcggcc agacgccgcc 17760 agtcacgccc gcccggctcg gccggcagat ccaccagacc gccccactgc acaggcgcct 17820 ccaacgccgc cacccgccca agcccccaca cacgcgcacc catcgcacac ggcacctcac 17880 ccggcccgac cgccaccgca ccccgagtgg ccacccagac ccgggctttc ggtgcgccgt 17940 ccgtcacggc ctgggtcacg agcagcacgg cggccgtgcc cgggtcgagc gggaaggcat 18000 cggccggtgc ggcgtccgct gcccggccgg gtagcaccag tacgcccgcc aacccctgcg 18060 ggcccgcggc gagttcggcc agccgctcgg tgagggcgac gcgcgcgacc tcggccggat 18120 ccagcggaca acgctccacc accgcgccgg ccgtgccgag tgccgttgcc gcggcgtcgg 18180 cctcgtccgg cgcagcgccg gggagctcca ccagcagcca gcgcccggac ggcgcaccgg 18240 aaccgccggt ctccagggcg gtccaggtga cccggtagcg ccaggcggcg gactcgtcgg 18300 cgggggcctt ggcggtgcgc cggccgacgg cggtcggcag ccagaaccgg tcacgccgga 18360 aggcgtacgt gggcaggggt acacggcggg cgccggcgcc ttcgaagagg gggctccagt 18420 cgacccgtac tccatgggcg aacgcggcgc ccaccgaggc gcggaaccgg tccaggccgc 18480 cggagccgcg gtggagggtg gacagcgcgg tggcgtgcac gccctcggcc tcggcgatct 18540 cgtcgatcga ggagcccagc agggggtgcg ggcccatctc gacgaaggtg cggtggccct 18600 ggcgcagcag cgcccgcagg gtggactcga actccaccgg ttcgcgcgtg ttccggtacc 18660 agtacgcggc gtccagaccc tcagggtcgt gtgctccggc ggtcacggtg gagaagaacg 18720 gcagccgggc ggcggtcggc cggacgtcgg cgagcgtgcc gaggagctcg gtgcggaact 18780 gctccacctg cggcgagtgg ccggcgaagt cgacgccggc gaggggccag cgcagtaccc 18840 cgtcggcgga caaccggacg ccgaactcct ccagcgcctg cgcgtcaccg gccacggtga 18900 ccgaggcggg gccgttgacc gcggcgacag agatccgctc cgcccagggc tccagcagct 18960 cgcggacccg gtcggccggg gccatcacgg agaccatgcc gccgtttccg gccagtcgcc 19020 cccacaacct gctgcgctcg gcgatcaccc gggccgcgtc gtcgagggac agggcgcctg 19080 ccgcgtaggc ggcggcgacc tctccctggg agtggccgac gacggcggcg ggccgtacgc 19140 catgggcctc ccacagcgcc gcgagggaga ccatcatggt gaacagcgtc ggctggacca 19200 cgtccgcgcg gtcgatcggc ggggcgtcgg ggccgccgcg cagtacgtcg agcaccgacc 19260 agtcgagatg tgctgcgagc gcccgcgcgc actcctcggc cttgacgcgg aaggccgggg 19320 ccgactccag cagttcggcg cccatgccgg tccactggga gccctgcccc gggaagacga 19380 agacgggggg ccggccgctg cccgcctcgc cgacggcgac gtcgacgtcc ctcctgccct 19440 ccgccagcgc ggtcagccgg gcgatcagcg actcccggtc gtcggcgagg accgaggccc 19500 ggttcgagag tgcggcacga gtggtggcgg cggagtaggc ggcgtcggcg gcggtgatct 19560 cctcgtggtc ggccaggtgt gcggcgagcc tgcgggcctg ctcgcgcagg ggttgcgcac 19620 cggcggccga cagcgggagg acggtggtgg gggagacggg cggctcctcg ggttcctcgg 19680 gttcggcccg ggcggtcggc gcctcctcga caacgatgtg ggcgttggtg ccgctgatgc 19740 cgaacgagga gatcgcggcc cggcgcgggc cgtcggcccg ctgcggccag ggcctggcct 19800 ccgcgagcag ctccacggct cccgcacccc attcgatctt ggacgaggcg gtggtggcgt 19860 gcagggtgcg gggcagcgtg ccgtgccgca tcgcctccac catcttgatg acaccagcca 19920 caccggcggc ggcctgcgtg tgcccgatgt tggacttcag cgaccccaac cacagcgggt 19980 cgcccgcccg ttcgcgcccg taggtggcca tcagcgcact ggcttcgatc ggatcgccca 20040 gcggtgtgcc cgtgccgtgc gcctcgaccg cgtccacgtc ggcgggagtc agcccggcat 20100 cggccaacgc gtcgcggatc accttctgct gggccggacc gctgggcgcg gtcaggccgt 20160 tgctggcgcc gtcctggttg acggcgctgc cccgcaccac cgccagtacc gggtggccct 20220 tcttctgagc ctccgacagc cgctccacca gcagcattcc ggctccctcg gcggggccga 20280 agccgtcggc cgcctccgcg aaggccttgc agcggccgtc gggggcgagc ccgcgctgcc 20340 gggagaactg agtgaagagg gcgaagtcgg cgatgaccgt ggcgccgccg gccagtgcga 20400 ggtcgcactc gccccggcgc agcgactgca ctgccaggtg cagtgccacc agcgacgagg 20460 agcaggccgt gtcgatcgtc agcgccgggc cctccaggcc cagggcgtag gcgacccggc 20520 ccgcggtgaa gctgacgatt ccggccagga gctgggcctc cagctcggct tcgagcccct 20580 cgacgccctt ctggtagccg ctctcccacg ccccggcgaa cacgccggtg cggctgccgg 20640 ccagggactg ggggtcgagg ccggcccgct ccagtgcctc ccaggacgtc tccagcagca 20700 gccgctgctg gggatccatg gtgagcgcct cgttggggga gatcccgaag aggccggggt 20760 cgaaccggtc ggccccctgc acgaagcccc cctcgcggca gtacgtggtg ccgggcgtgt 20820 cggggtcggg cgagtacatc gcctccacgt cccagccgcg gtcggccggg gccaggctga 20880 cggcgtcggt cccggcgagc agcaggtccc acagttcgtc cgggctgcgg acgccgccgg 20940 gcagccggca ggccgccccg acgatcgcga tcggctcgtg ggcccgctcg tccagggtgc 21000 gcagctgctc ggtggcccgg tgcagctcgc ccgtcacgcg cttgaggtag gcgcgcagct 21060 tctcttcgtt cgccatggtg gtacttccct tcgaggactg gcgacggggc gccgaaccag 21120 tggtcacgac gcgccgtacc gctcgtcgat gaacgcgaag atctcgtcgt cgtcggcggt 21180 gctcaggacg tcggcgatgt cgtcgtcgac gccggccgcg ccgtcgtgca gggcgcgcca 21240 gcggtcggcg agtgcgtcca ggcgcagggc gacctcggcg cgggcgtcgg gggcgggtgc 21300 gaccgccgcg agaccttcgg gggtgagggc ggccagggcc tcctcgatcc ggtcgagttc 21360 ggacagcagc ggtgcggtgg tgggcggccg ctggggcgcc agcaggccgt cgaggtgcgc 21420 ggccagcgca gccggggtgg ggtggtcgaa caccagggtg gcggggagcc tgaccccggt 21480 gaccgcgccc atccggttgc gcagttccac ggccgtgagc gagtcgaatc cgacctcgcg 21540 gaacggccgg tcggagcgga cctccgcggc ggagccgtgg cccagcaccg cggccacgtg 21600 ttcgcttacc aagctgagca gctggtcgtg gcgttcttcg gcggagagcc tggccagccg 21660 ttcggcgagc ggctcgccgg tgtgccccgc gtccggtgtc gggtacgggc cggcggccgg 21720 ggttgcggac ccggcggccg gggcgggtcc gacgaggtcc gacagcagag cggggactgt 21780 tccggtggcg cgcagcgcgg ccgggtcgaa ccgcatgggg atctgcacgg cctcgtccac 21840 tcgcagggct gcgtcgaaca gtgcggcgcc cagggtcgct gacaggggag ggaagccgtt 21900 gcgggcgaag cgccgctgga ggctctcctg gtccagtccg ccggccatcc ggctggtgtc 21960 ggaccacagt ccccaggcca gcgacaccgc ggggaggccg agggcccgcc gccggacggc 22020 gagggcatcg agcgtggcgt tggccgctgc gtaattgccc tgcgccgggc tgcccagcag 22080 accggcgctg gaggagaaga ggacgaatgc cgacaggtcg aggtcgcggg tgagttcgtc 22140 caggtggacg gcggcctcca ccttgggacg cagcacgcgc cgcatccgct cgggggtgag 22200 cgtgggcagc acgccgtcgt cgaggacgcc ggcgctgtgc accaccgccg tcagcgggtg 22260 ctcggccggt acgccggcga gcagccggcg gaccgcgtcc gcgtcggaga cgtcgcaggc 22320 gacgacggtg gccgaggcgc ccagggcggt gaggtcggca accagttccg cggcgccctc 22380 gccgtccggg ccgcggcgtg cggcgatcag cagctggcgt acgccgtgat gggtcgccag 22440 gtggcgggcg atgcggccgc cgagggcccc ggtgccgccg gtgatgagca ccgtgccgta 22500 cgggtgccag gcgggcggca tggtcaggac gagctttccg gtgtgcctgg cctggctgat 22560 ggtgcgcagg gcgtccgcgg cccggcgcac gtcgtgggtg acgacgggca gtgggtgcag 22620 cactccggcg gcgaacagtt ccatcagttt ccgcagcagt cggccgagtt cgtcgggtcc 22680 ggcctcgttg aggtcgaacg cccggtagcg gactccgggg tggtcggcgc cgacctgctc 22740 ggggtcccgt acgtcggtct tccccagctc caggaaccgg ccgcccgggc ggagcagccc 22800 gagggaggcg tccacgaact ccttggtgag cgagttcaga acgacgtcgg cgcgggacgt 22860 gccgtccgta ccggcgaagg cggtggcgaa gtcgagggtg cgggaggagg cgaggtgttc 22920 gtcggtgatt cccatggcgc gcaggacgtc ccacttgccg gtgctcgcgg tggccagcac 22980 ctcggcgccg aggtggcggg cgatctgcac cgcggccatg ccgacgcctc cggcggcggc 23040 gtgcacgagc accttctccc ccggtcgcag gtccgccagg gtgaccagcc cgtagtaggc 23100 gctgaggaac accgcgggga ccgaggcggc ccgggcgtag gaccagccgt ccgggatcgg 23160 gacgagcagc cggtggtcgg ccacgcacac cgggcccagg ccgccgttcc acaggccgag 23220 cacccggtcg ccgggggcga cgccggtgac gccggggccg acctcgacga cggtgccggc 23280 gccctcggtg cccatttccg cctcgcacgg atacatgccg agggcgatga gggcatcgcg 23340 gaagttcacg cctgcggcgc gtacggcgac gcgcacttgg ccgtgctcca gcggggcctc 23400 cgcgtccggg gcgggcacca gcgcgaggcc gtcgagggtg aggtcggcgc ctcggccgag 23460 ccgccaggcg cccttctccg gcggggtgag cggcccgtcc gtgctgtcgg cggcccgctc 23520 cagccggggt acgtacaccc tcccggcacg caccgcggtc tgcggttcgc cggaggcgag 23580 ggcggtgggc agcgccctcg cggacgccgg gtcgtcgtcc aggtccacca gcaggaaccg 23640 gtcgggctcc tcggcctgcg cggagcgcag caggccccat gcggcggccg cggccgggtc 23700 gctcacctcg gcgtcgccgc gtacggcgac cgcgccgcgg gtggccacga ccaggcgggc 23760 gccttccggg gcgtccgggg ctgcgagccg gcgctggaca aggtccagca cctggcaggc 23820 gacggcgtgg gcgtcggcgg cgacatcgcc ggttccggtc ggcactccga acacgaaggc 23880 gtccggcgcc gcttcgccgg ccgcggtcgg cagcgggccg tccgggccga gtgcgtcggg 23940 caggtgtgcg tcggcggcct cggccaggcc cagcacgtcg ggccccgcga ccacccagcg 24000 caccgaggaa gcggcgccgg cgccgttgcc ggtacggagg ccggtgcccg agccgctggt 24060 gagctcccgc caggcgatgc ggaagagcgc gtcggcgccg accgggcggc cgcccaggag 24120 ctgctcgggg tcgaccggcc gcatgaggaa cgagtcgatc tcggcgaccg cccgtccctc 24180 ggtgtcggcg caccggatgc ggacggcgtc ctgggagacg ggcgagatgc gcacgtgcag 24240 ccgctcggct ccggtgcggt acagccggac gccgcgcagc gcgaagggca tccggatgcg 24300 gccgtcctca gggaagaagc cgcccaggct catggtctgc agcgccgcgt ccaacagcgc 24360 ggggtggatt ccgaaccgtg ccgcgtcgcc ctgggcctgg acgggcagcg cgacctccgc 24420 gtggatgtcg gagccggagc ggtgcgcgct caccagtccg cggaagaacg gcccgtagcc 24480 gtagccgagt tcggcgaaac gctcgtagaa gtcgccggtg tccagttgtt cggcgccggg 24540 cggcggggct gtcgccgagg cgtccggcac gtcggcggcg tcctccgcgg tgagcagccc 24600 ctcggcgtgc agggtccagt ctgcggcgcc ctcggcgcgg gcgtgcacgg cgaagcggcg 24660 ggcgtcgtct gcgcccgggg cgccgacgtt cagccgcagc cggacaccgc cggactcggg 24720 cagcgccagg ggtgcggcca gggtgagttc ctcgatccgg ccggtgccgg cctggcggcc 24780 ggcccagagg gccaggtcgg cgaacgcggc gcccggcagc agcgccgccc ccatcagtgc 24840 gtggtcggcc agccacgggg tggcgtcggt gcccaggcgc gcggtgtaca tctgagcgcc 24900 ggagtcgggc agttccacgc cgccgccgag cagcgggtgg tcggcggcgt ccaggccgag 24960 ggaggcgggg tcgtcgccac ggctggtggg gctgtaccag tagcgctcgc gctggaaggg 25020 gtaggtgggc agttccacat gacgcgagtc ggggccgaag atggcctccg cgtcgatctc 25080 cacgccgtgg gtgtaggcgc ggcagacggc gacggccagg cagcgggggc cgccctgacc 25140 gcgacgcagg gtgccgagaa ccgccgcgga ggcgccggcg tcgctgatcg tctcctggag 25200 ggagacggcc agcatggggt gcgggctcga ctccaggaac acgtcgtggc cgtcggcgat 25260 cagggcgcgg gtggccttct cgaactccac cggctcgcgc atgttgcggt accagtagtc 25320 ggcgttcagc tcggcggtgt cgagcagccc accggtgacc gtcgagtaga acgggatgtc 25380 ggaggatcgc ggcgcgaccg gggcgagcac ctcccgcaga tgctcctcca gcatgtcgac 25440 ctgcggcgag tgcccggcgg tgtcgacgcc ggggatcggg cgggcgtgca ccccctccgc 25500 gctgagttcg gcgaccagct ctgccagggc gtccgggtct ccggagacgg cgcaggtctc 25560 ggggccgttg acggcggcga cggcgagccg gtcgctccag ggctccagcc ggggacgcag 25620 gtcgcgctcg gacatggtca ccgcgaccat gccgcccttg ccggccagcc gcagccatgc 25680 ctggctgcgc agggcgacga tgcgcgccgc gtcgtccagc gagagggcgc cggcgacgtg 25740 ggcggcggcg atctctccct gggaatgccc gacgaccgcg gccggttcga cgcccagcga 25800 acgccaggtc tcggcgagcg agaccatcat ggtgaacaac acgggctgca ccacgtcgac 25860 ccggtcgagc gagggcgcgc cgggttcccg gcacagcacg tccagtacgg accagccgag 25920 gtggggccgg agcgcggcgt cgcaggcgcg tgcggtctcc aggaaggagc tggagtcgct 25980 ggagcggtcg aacagcccgt cggccatctc gggccattgc gagccctggc cggggaagac 26040 gaacaccacc tggtcggcgg tgccggcggt gccccgcagc acgagcgggt gcggccggcc 26100 ttcgacgagg tcgtcgaggg ccgcgatcag ctccgtgaag ttctcgccga ccacggcggc 26160 ccgctgctcg aagcgggtgc gggtggtgat gagggtgtag ccgacgtcgg ccgggtgcag 26220 ctcggggtgg gcgagcaggt ccgcgcgcag ccggcgcgcc tggtcgcgca gggcggcgtc 26280 gttgtgcgcg gacatcatca acggcacggt cacctcgtgc caccactcct cggaccagac 26340 gtcgccgtcg gcggccggtt cgggcgcgag cagctcgggc gcggtgggct ccggcggctc 26400 ctcgacgacg acgtgggcgt tggtgccgct gatgccgaag gaggagattc cggcccggcg 26460 cagtccgtcg gcccgctggg gccagggcct ggcctcgtcg agcagttcca cggctcccgc 26520 atcccattcg atcttggacg aggcggtggt ggcgtgcagg gtgcggggca gcgtgccgtg 26580 ccgcagggcc agcaccatct tgatgacacc ggccacaccg gcggcggcct gggtgtgtcc 26640 gatgttggac ttcagcgagc ccagccagag cgggtcgtcg cgccggtccc ggccgtaggt 26700 ggcgagcagt gcgcctgctt cgatcgggtc gcccagcggt gtgccggtgc cgtgcgcctc 26760 gaccgcgtcg acgtcggcgg gggtgagccc ggcatcggcg agcgcctcgc ggatcacctt 26820 ctgctgggcc ggaccgctgg gcgccgtcag gccgttgctg gcgccgtcct ggttgacggc 26880 gctgccccgc accaccgcca gtaccgggtg gcccttcttc tgagcctccg acagccgctc 26940 caccagcagc attccggctc cctcggcgag gccgacgccg tcggccgtct cggcgaacgc 27000 cttgctgcgg ccgtccggcg agaccgctcg ctggcgggcg aactccacca gcatctcggg 27060 ggtggacatc accgtggcgc cgccggccag ggcgtagtcg cactcgcccc ggcgcagtga 27120 ctgcaccgcc aggtgcaggg cggcgaggga ggccgagcag gcggtgtcga cggtgacggc 27180 ggggccctcc aggccgaaga cgtaggagag ccggccggac atcacgctgg cggaattgcc 27240 ggttgcgatg taaccgtcga agctctcgtc gccgtcctgg agcagcggca cgtagtgctg 27300 cccgttggtg ccgacgaaga ctccggtgcg gctgccgcgc agctccaccg ggtcgatgcc 27360 ggcccgttcg aaggattccc aggaggtttc caggatcagc cgctgctgcg ggtccatggc 27420 cagggcctcg cgggggctga tgccgaagaa gccggggtcg aactcggccg cgtcgtgcag 27480 gaatccgcct tcgcgcacgt aggtgtggtg tccgggtgag ccggggtcgg ggtcgtagag 27540 ggcttcgttg ttccatcccc ggtcggtcgg gaacggggtg atggcgtcga cctcgccggt 27600 cagcaggtcc cacaggtcct cgggggactg gaccccgccg ggcagccggc aggccatgcc 27660 gatgatggcg atgggctcgt ccgtctgtgt cggggtctcg gggccggtcc ggtcggcggt 27720 gtcgccccgg ccgaggagtt cctcgccgag gtggcgggcg agcgcggccg ggttggagtg 27780 gtcgaagacc agggaggtgg gcagcttgag gccggtggcg gtgctgagcc ggtcgcgcag 27840 ctccagggcg gtcagcgagt cgaagccgag gtcgcggaag gcgcgggcgc tgttcaccgc 27900 gtcgccggag gactgcccga ggacggcggc ggcgtgggcg cggaccagcc gcagcagggt 27960 gacgtgccgc ttgtggccgg actgcgcggt cagttcgcgg acgagttcgg aggtggtcga 28020 gtcgccgttg ctcggggcga gttcgaccgc gcgcagccgc tgcacgtccg ggatgtcgtc 28080 gaacagtacg gcggggcgca cccaggtgta ggaggcggcg aatcggttcc actcgacgtc 28140 ggcgaccgca ccgcaggcgc tgccgcgctc cagcatgcgg cgcagggtcc gcactgcctc 28200 gtccgggtcg aggggggcca ggccacgccg gttgaggaac tccgcttcgg cgccgtcggc 28260 gggcgtgccg ccggcccagg ggctccaggc cacggagagt gcgggcactc cggcggcgcg 28320 ggcgcgttcg gccagcgcgt cgaggtgcgc ggtggcggcc gcgtagcagc cctgggccgc 28380 gccgccccac acgccggaga ccgaggagaa cagcaccagc gcatcgaggc cggcggcggg 28440 cgccaggtcg accaggtggc cggcggccgt ggtcttggcg gcgagggcgg tggcgatgtc 28500 gccgggcgcc gtctcgttca gcggggccag cggtacgagc ggcggggcgt gcacgacgac 28560 ggagggcgcg tgctcgccga gcaggccggc cagggtggtg cggtcggtga cgtcgcagcg 28620 tacggggacg acggaggctc cggtgagtcc ggcggcggcg gcctgtgcgg gggcgtcggg 28680 cccggccagc accacgcggt ccgcgccgtc ctccaggagg gagcggatca gccgaccggg 28740 caccgtcgtg atgtcgccgg cgatgaggac ggtgccccgg gcgcgccagg ccggggagcc 28800 ggcgtcggcc gggttccgca ggacgcggcg gccgaagacg cccgccatcc ggatggcgat 28860 ctggtcctcg ccgccgggtt cggcgaggac gccggcgagg cggtcgagga cccgggcgtc 28920 gggctgcgcg ggcaggtcga tgaggccgcc ccacacctcg ggcagctcca gcgcggccac 28980 ccgtcccagg ccccacagtt gggctccggc ggtgcacggc agttcgtcgg gggcggtggc 29040 gaccgcgccg caggtgacgg tccacagcgg tgcggtgctg ccgaggtcgg ccagggcctg 29100 gaccagggcg agtgtggcgg tgactgcggt gggcacggcg gggtggtcgg gccggccgtc 29160 ggtgcacagt ccgagcagcg aaacggcgcc ggtgacggcg gtgtcgccgt tgattgccga 29220 ttcgagcagg ccgagcagtt cggcgcgtcc ggtgcgggcc gggtcgacgg cgatgcggcg 29280 gaccgttccg ccgaaggagg cgatcgcctg ttccacggtg tcggcgaggg cggcgtgctg 29340 ttccccggtg ggcacgatca gcaggcgcag gcccgggcgc cagccgccgg tggcggagcg 29400 cagccccttc cactcgacgt ggtagccgag ccggtcgccg gactccgggg cgccttcgcc 29460 ggtttcggcg gtcttcgccc ggtcgggccg ggcggagccg acccagtagc gttcgcgctg 29520 gaaggcgtag gtcggcaggt tcacccggcc ggccccgggg tggagcgtgg cccagtccac 29580 cggtacgccg acgacctggg cctccgccgc ggaggtgagg aagcgccgca gaccgccctc 29640 gtcgcgccgc agcgagccga cggccggtac cgcggtgccg acgctttcca cggtctggcg 29700 tacgccgacg gtgaggacgg ggtgcgcgga gcactccacg aacgcgtcga tgccgtcggc 29760 gagcatggcg cgcacggtcg gctcgaagcg caccgggagc cgcaggttgc ggtaccagta 29820 gtcggcgtcg agggcggccg tgtcgaggag cgccgcctcg acggtggagt agaagggcac 29880 gtcgcctctg tacggccgga ccggggcgag gacggtggcg agctcctccc ggatgctctc 29940 gacgtagtgg gagtgggagg cgtagtcgac gtcgatgcgg cggactcggg agccctcggc 30000 ctccagggcg accagcagcg cctccagggc gccgggctct ccgcagacga cggtcgaccc 30060 ggggccgttg acggcggcga tctccacgcc gccggcgagc cgtgcctcga catcggtcgc 30120 gggcagggcc accgaggcca tgccgcctcg cccggccagt tcgcgggcga tgacctggga 30180 gcgcagggcc acgatccggg cggcgtcgtc cagggagagc gcgcccgcca cgcaggccgc 30240 ggcgatctcg ccctgggagt ggccgatgac ggcggcgggt tcgacaccga gggatcgcca 30300 cagcgccgcg agtcccacca tgacggcgaa ggtggccggc tggacgacgt cgacgcggtc 30360 gaggccgggc gccccgggcg cgccgcgcag tacgtcgctg agggtccagt ccacgtacgg 30420 ggagagcgcg ctctggcaga gctccagttc ggcggcgaag gccggggccg tgtccagcag 30480 ttcggcgccc atcccggccc actgggagcc ctggccgggg aagacgaagg cgacccggcg 30540 gatgtccgcc gcggtgccgt gtacggcgtc cggggtggtc tcgccggcgg cgagggcggc 30600 gagggcgtcg accggggcgc cgttgtctcc gagcagcacg gcgcgttggg tgagggcggc 30660 gcggtcggcg gccagcgcat ggccgatgtc ggtcggcgag gtgtcgggga ggcgctcaag 30720 gtgcgcgcgc aggcgtgcgg cctgggcgcg cagggcggga gcggtctcgg cggacagcgg 30780 ccagaccacg gtggaggggg tcgcgggcgt gtcgccggtc atggacgctt cgtccggtgc 30840 ggacgcgggg cgaggagcgg acgcgtcgcg tggtgcggac gcgtggcctg gcgcggacgc 30900 gacgcgtggt gcggacgcat ggcccggcac ggacgcgacg cgtggtgcgg acgcatggcc 30960 cggcacggac gcatggcccg gcacggacga gacactggtt ccagccgccg cgcctgccgc 31020 gggtacctca cctgtcacag gcgcgtcgcc ggtcacgggc tcctcgcctg ccacaggtgc 31080 gtcaccggct gcggctgcgc cgcctgttgc ggtctcggcg ggcggttcct cgatgatgac 31140 gtgggcgttg gtgccgctga cgccgaaggc ggagatcgca gcccgccggg gacggtgctc 31200 gcgctgcggc cagggccggg cgtcggtgag caactccacg gcgctcgggt cccattcgac 31260 cttggccgag ggtgcgtcga cgtggagggt gcggggcagc gtggagtgcc gtatcgcctc 31320 caccatcttg atgacgccgg cggctccggc ggcggcctgg gtgtgcccga tgttggactt 31380 cagcgagccc agccacagcg ggtcccggcc ctggcgctca cttccgtagg tggccatcag 31440 cgcaccggcc tcgatggggt cgcccagagg ggtgccggtg ccatgcgcct ccaccgcgtc 31500 cacgtccccc ggggccagtc cggcatcagc caacgcctcg cggatcacct tccgctgggc 31560 cggaccactg ggcgcggtca ggccgttgct cgcgccatcc tgattgaccg cactcccccg 31620 caccaccgcc agcacccgat gcccataccg acgagcatcc gacaaccgct ccaccaacaa 31680 cacaccaaca ccctcggccc acacagtgcc gtccgcaccc tccgcaaacg ccttgcaccg 31740 cccgtccgac gccagcccac gctgccgcga gaactccacg aacaccgtcg gcgtcgccat 31800 caccgtcacc ccaccggcca acgccatgtc acactcaccc cgccgcaacg actgcaccgc 31860 cagatgcaac gccaccaacg acgacgaaca cgccgtgtcc atggtcacag cggggccctg 31920 caggccgagc gtgtaggcca cccggccgga tgcgacgctg cccgcggtgc cgaggccgag 31980 ctgtccgctg ggatcggcgg cggtgccgac ctggtggctg ccgtagtcgt ggtacatcac 32040 gccggtgaag actccggtac gggtgccgcg cagcgagtcc ggcacgatcc cggcccgctc 32100 caacgcctcc cacgacgtct ccagcaacaa ccgctgctgc ggatccatcg ccgccgcctc 32160 acgcggcgaa ataccgaaga actccgcatc gaactcggcc gcctcgtgca ggaagccgcc 32220 ctcccgcacg taactcttgc ccggcacgcc cggctccggg tcgtacagcc cctcggcgtc 32280 ccagccgcgg tccgcgggga acggggagat cgcgtccgta ccggcggcca cgaggtccca 32340 gaggtcctcc ggcgacgcca caccgcccgg gtagcggcac gccatgccca caatcgcgat 32400 cggctcacga ctcgccgact cgacttcgcg cagccgctcg cgcgcgctgt gcaggtcggc 32460 catcgcgcgc cgcaggtact cccgcaactt ctcctcgttc gttgcagaca cggttctcct 32520 catgcgtcat gtcatgggtc agggtgcgga gcggttcagc agccggcgcg cggcgcggtc 32580 cggctcactg gaaatcgctg tcgagcaggt cgaacaagtc gtcgtcggag gccgacctga 32640 gccggtcgat caccacatcg ccggggccgt gggggctttc tccggcgccc ggtccggatt 32700 gctcgccgga gccgacggtg agcgcggcca gcaggccgcg cagccgctgt gcggcgcgga 32760 cacgggcatc gccgtcgtcg gtcgcggcga ggctgcgctc cagccggtcg aatgcgctgg 32820 acaggtcttc ggcaccggcc ggttcgtccg ggaccgggcc ggccggttcc gctcggcctg 32880 ccgccgtcaa ctcgccgagc aggagttcgg cgagggacag cggtgtgggg tggtcgaaca 32940 cgagggtcgc gggcaaccgc agcccggtgc gcgcgttcag ccggttgcgg agatcgacag 33000 ccgtgaggga gtcgaatccg gcgtccttga aggaacgggc ggcgcccacc gcggcggtgt 33060 cgccgtgtcc cagcaccgcc gcgacctcgg tccgcaccag gtcgagcagg agggccgtcc 33120 gctcgggcgc ggagcgcccc gcgagccggg tcgccagtgc cgcggcggcg tcggccgggg 33180 cgggaggccg gtggccggta ccggcctcgc ccccggcgcc cgccacggct ccgggcgcgc 33240 tcccgccgtc tgccgggacg ccgaccaggt cacgcagtac ctccggcaga acggtggcac 33300 gggccgcggc gcgcaggtcg aggcgcacgg gcagcagtgc gggctcgggc ctgaccaggg 33360 cccggtcgaa cagctccagc gcggcccggg ggtcgagcgg ggcgacgccg gagcgccgga 33420 tacgcgcggc gtccgctctc tccagcccgg tggccaggcc caggccggac caccagcccc 33480 agccgagcga cagcgcgggg tgcccggcgg cgcgccgccg ggcggccagg gcgtccagga 33540 acgcgttggc cgcggcgtac ccggcctggc ccgcactgcc cagggcggcc gagaccgagg 33600 agtacaacac cagtggaacc ggcccgagtt cacgggtcag ctcgtccagg tggacggcgg 33660 cgtccgcctt gggccgcagt accgcgtcga tccgctcggc agtctggacg gagagcacac 33720 cgtcgtcgag caccccggcg gtgtgcacga cgcaggtcag cggatgttcg gcggggagct 33780 cgccgagcag gcggcggagg gcgtcgcggt cggcgacgtc acaggcccgg acggtgacct 33840 cggcgcccag attcgtgagt tccgcggcca gttcggcggc gccgggtgcg tcggggccgc 33900 gcctgctgac gagcaggagg tggcgcgcct tgtgccgttc cacaaggtgc cgggcggttt 33960 ctgcggccag tgctccggtg ccaccggtga tcagcacggt gccgttgggg tccagcgtct 34020 cggccggctc cccggcaccg gtctcgtcgg ccgctgtgtc gctgccggtg tccaggtcgg 34080 ccacgtcggc cacgtcggcc acccgtacga ggcgcgggac ggcggcgcgt ccatcgcgca 34140 cggccaactg agcggtgtcc gtggccagca ggccgggcaa ggcccgcagc gacgcctgcg 34200 cgccgtcgac gtccaccaga gtgaagcggc cgggctgttc ggcctgggcg acccggacga 34260 gcccccagac agcggcaccc gcgggatcgg ccgcgcctcc ctcgggaccg gccgcacccc 34320 gggtcaggac cacgagccgc gggcggccgc cgggacgggt ggctgtacgg gcgtccgtac 34380 ggacgccgga gtctgcaccg gcatccgcgt tggtgtcggt gtcggtgtcg gtgtcggcga 34440 gtcgggcctg tacggcttcg agagtccggc gcaccgtcgc acgcagctcg tcgaggaggc 34500 cgaggagcct gccgtggggc gccgtacgac tggcggtggc ggtggcggtg gcggtggcgg 34560 tggtcaagtc gaggaggatc acttcggcgt ccgcgccgac ctgcggcggc agcggctcgt 34620 cgaaggggag cacgtgggta cgggcgtcga tgccgacggc acgcagcccg gccgcggtgg 34680 cttcggcctc cggtccgacg accgcccagc gcgtgactgc ggcgacggac actcgcccgg 34740 gaagcggcac ccagtccacg cggtagagag gggcggcggg tgcggcggga agccggtccg 34800 cgggtatgcg acgcagtgcc agggagcggg cggaaagcac tggggagccc tcgcggtcga 34860 ccgcggcgat cgacaccgcg ccgccgtcga cggccgccac ccgtacccgg agcgcatgtc 34920 cggcggcatc gtggcgccgt acgtcggtcc aggagaacgg cagcaagccg tgtccgccgt 34980 cgcccaacgg gtcgagcagc gcgatcgggt ggagagccgc gtcgagcagg gcggggtgca 35040 ccccgtaacg ggcggcatcg gcggcgtgcg cgtcgggcag ccgcacttcg gcgaagatct 35100 cgtcgccgcg acgccatgcc gcgcgcagcc ctcggaaggc cccttcgtag cgcactccgg 35160 cggctgcgaa gagcgggtac tgaccggcga tgtcgagcgg ctcggcgccg gcagggggcc 35220 aggcgccggt gagttcggcg aaggcgtcgg caccggttcg gtcggcaccg tgggggtggc 35280 cgctctcgtg ggggtgggga gccccgtggg ggtggccggc ctcgtgcgtg tggtcggcat 35340 ggtcggcagc cggggcgagc agcccggagg cgtgccgggt ccagccgttg tcacgatcct 35400 gcgccgcgag gtgcggggaa cgggtggaat gcgaggggtc ggcgacgggt tcgggccgtg 35460 agtggagact cacctcacgg gcacccccgg ggccggaggc aggagcggcc acgacgaccc 35520 ggatctggac cgggttgtcc gcagcccagg tcagcgcggt ctcgaaggcc agttcggcga 35580 cgcgcggcag accgatccgg cttcctacct ggagcagcat ctccagcagt gcggatcccg 35640 gcaccacgcc gcggtcccac accaagtggt cggcgagcca cgggaggtcc gcagcggaga 35700 tccggccggt ccacacctcg gtttcggcgc cgggcagttc cacggcggcg gcaagcagcg 35760 ggtgttccac cccatgcagg cctgccgccg acaccccgcc ggtcgtgagc cggggcagag 35820 ccgccagcca gtagcggtcc cgatggaagg cgtacgtggg caggtcgacc cgccggccgg 35880 caggctcgga gggagccggc ggcaccggaa ggccccgggc gtagagggtg gcgagtgcgg 35940 tggtgaaggt ctccagctcc ggccggtcac gccgcagtac cggcacgaaa gcaagatcac 36000 cctcgtcccc gtcgagacac tgccccgcca tcaccgtcag aacagcatgc ggacccacct 36060 ccacaaacgt atccacaccc acatcacgag cagcccccac accatccgcg aaccgcaccg 36120 cctcccgaac atgccgcacc cagtactccg gatcccccaa ctcatccaaa cccgcaaccg 36180 cacccgtcac actcgacacc accgccacac cagaacgagg ccggtgaaac tccaccgaag 36240 cagcaacccg acgaaactcc tccaacatcg gatccatcaa caccgaatga aacgcatgcg 36300 aaacctccaa ccacctgcac tccacaccac gacccaccaa acccgccacc acaccatcca 36360 gcacccccgc ctcacccgac agcaccaccg acgccggacc attcaccgcc gcaaccgaca 36420 cccgaccacc caacccagcc accaaacccg ccagctcggc ctcagacgcc cccaccgaca 36480 ccatcgcccc acccacaggc aacgcaccca tcaaccgacc acgcgccacc accaaccgca 36540 ccgcatcagc caacgaaaac acacccgcca catacgccgc agccacctcc cccaccgaat 36600 gacccaacac caccgacaca cccacacccc gagcctccaa cgcccggaac aacgccacct 36660 ccaacgcaaa caacgccggc tgagcaaact ccgtacaccc caacaacccc gcatccacac 36720 tccccgcctc cgcaaacatc acctcacgca gagaccgacc ccccacctcc cccacaaccc 36780 ccaacacctc atccaacaca cccgcaaaca ccccacccgc cccatacaac tcacgcccca 36840 taccaaccca ctgcgcaccc tgacccgtaa acaacacccc cacccgacgc ccccgcaccg 36900 ccgaaccccg caccacaccc gacgcggcac cccccgcagc aaccacaccc gccgccacag 36960 catccagacc ggccagcagc tccccacgct cccgaccgac aaccaccgca cgctcaccga 37020 acgacgcacg cgacaccaca agcgaatgcg caacatccac cggatcagca cccacacgct 37080 ccacgtgctc ccgcaaccgc accgcctgcc cccgcaacgc ctcctccgaa cgggccgaca 37140 ccggccacgc cagaaccgaa gaggactcag ccgcagcagt gacaacagcc tcggcttcgg 37200 ccgactcctc gaccgacggt tcctcgatga cgacatgggc gttcgtcccg ctcacgccga 37260 aggcagaaac agccgcccga cgcacccggc ccgcccgccg gggccaggac ctggcctcgg 37320 tcagcaactc caccgccccc gaaccccact cgaccctcga cgacggagca tccacatgaa 37380 gagtgcgagg caacgacgaa tgccgcatcg cctccaccat cttgatcaca ccacccacac 37440 ccgcagcagc ctgagcatgc ccgatgttcg acttcaacga ccccaaccac aacggatcac 37500 ccacccgctc acgcccatac gtcgccagca acgcacccgc ctcgatcgga tcccccaacg 37560 ccgtacccgt accatgcgcc tccaccgcat ccacatcccc cggagccagc ccggcatcag 37620 ccaacgcctc acggatcacc ctccgctggg ccgcaccact gggcgccgtc agaccgttac 37680 tcgcaccatc ctgattgacc gcactccccc gcaccaccgc cagcacccga tgcccatacc 37740 gacgagcatc cgacaaccgc tccaccaaca acacaccaac accctcggcc cacacagtgc 37800 cgtccgcacc ctccgcaaac gccttgcacc gcccgtccga cgccagccca cgctgccgcg 37860 agaactccac gaacaccgtc ggcgtcgcca tcaccgtcac cccaccggcc aacgccatgt 37920 cacactcacc ccgccgcaac gactgcaccg ccagatgcaa cgccaccaac gacgacgaac 37980 acgccgtgtc caccgtcaac gccggcccct ccaaccccaa cacataagca acccggccgg 38040 atgcgatgct gccggcgctg ccgttcacga ggtagccctc gtactccggc ggggccgagt 38100 cgaactgcga tccgtagtcg tcgtacatca cgccggtgaa gactccggta cgggtgccgc 38160 gcagcgagtc cggcacgatc ccggcccgct ccaacgcctc ccacgacgtc tccagcaaca 38220 accgctgctg cggatccatc gccgccgcct cacgcggcga aataccgaag aactccgcat 38280 cgaactcggc cgccccgtgc agaaacccgc cctcccgcac ataactacga cccaccgcct 38340 ccggatcggg gtcgtacaac ccctcgacgt cccagccacg gtcgacaggg aacggagaga 38400 tcgcgtccgc accggcggcc gccaggtccc acaggtcctc cggcgacgcc acaccgcccg 38460 ggtagcggca cgccatgccc acaatcgcga tcggctcacg actcgccgac tcgacttcgg 38520 ccaggcggga cttggtcttg tggagttcgg cggtggcacg cttcaggtag ctgcggatct 38580 tgtcgttctc ggcggtcatt gctgccacca actcctcggc atgcggtcgg tccacggtgc 38640 ggtcacagct gctcgtccag gaaggcaaag atctcgtcgt cggtcgcctc gtcgagccgg 38700 tccgttacgg tcgccccggc gccgtcggca gcggcgggcg cggcgggcgc ggtgcggccc 38760 tggggtccga cgacgccgcg cccaggggtg tcgagcgcgg tcagaagccc gacgagccgc 38820 tgtcgtacct cgactcgacg ggcgtcgtcc gagcccagca gggcgaccgc ccgcgcaagt 38880 tcgccgatcc cctccagcgc ggcgtccacg accggggctc cggcggggcg gggcagctcc 38940 ccgtcgatcc actcggccat gtccttgggc gtggggtggt cgaaggccag cgtggtcggc 39000 agccgcaggc cgaccaggcg gctgagccgg ttgcgcagct ccaccgccgc cagggagtcg 39060 acgccgatct cccggaaggg gcgttcgggc tcgatctcgg cggccgacgc gtgcccgagg 39120 acctcggcga cctgttcggt gaccaggtcc agcacggccg tggaccgctc cgctgcgtcg 39180 agcgccacga tccgggcgat gcgtccggtg ccggactccg cccccttgcc gtgccggtcg 39240 gcagccgcag gggtgccggt actgctatgg cgcagggctg cgggaagcag gccgcgcagc 39300 aacggaggca ccgcggccgc gccgcgctcc ttggccgtgc gccgcagagc ggcgccgtcg 39360 aggaggagcg ggacgaggac ggcgggcccg tcccggtgcg cggtcagagc ctggtcgagc 39420 agcccgagcc cttgctcggg cggcatcgcc gcgatgccct cgcggcgcag ccgatggagc 39480 gccacgtcgt ccagaccccc ggccatgccc gccctctcgt cccacaggcc ccaggccagg 39540 gacaccgcgg gcagcccggc tgcgcgacgg gctcccgcga gcgcgtcgag gaccgcgttg 39600 gcggccgcgt aggagccctg ccccggacgg ccgaggagtc cggcggcagc ggagaacagg 39660 acgaacgcgc gcagcggtcg gtcgagggtg gcctcgtgca ggttccgtac ggcgtcggcc 39720 ttcgaccgca ggacggtgtc gagccgttcc tgagtcaggc cggtcagggc gccgtcgtcc 39780 agcacgccgg cggtgtgcac cacaccggtc agcgggtgtt ccggcgacac tgcgacaacg 39840 gccttccgca cggccgcggg gtcggcgaga tcgcatgcca ggaaggtggc ggtgacgccg 39900 aggccgacga gctcccgttc caggagggcg gcttcgggag catccggccc gcgcctgctg 39960 accaggagca tgtggcgcac gccgtgccga cgcgccaggt gcggggcgac gcgccgcccc 40020 agggcgccgg tgcagccggt gatcagtacc gtgcccgcag ggtcgaacac ggcgtccacg 40080 gcggaaccat cgggatcgaa cgcgccgtct gaggcggggc cgccggtcgc cgcgccgccc 40140 ctctcggccg gcccggccgc ttccggcgcg acgctctgtg ccgcgaccgc tgccgctgcg 40200 gagtccactg ccgtcgccgg ggttgctgcc gtcgccgggg tggtgatcgg aacgagggcc 40260 ggtgcgagca acgccccggc gcgcagggcg agttgcggct cgcccgattc cagagcccgc 40320 ggtagggccg cacgggattc cggggagtcg tccacatcga cgagggtgaa gcggtcgggg 40380 tactccgact gggcggagcg gagtagcccc cacagtgccg cacccgccag gtccggcact 40440 tcgccggaac cggcctcgac cgcgccccgg gtgaggacga cgagccggga atccgccaga 40500 cgttcgtcct cggtccactc ccgcaccaag gccaggccac ggccgagggc gacgcgtacg 40560 gggtcgtcgc cccagtccgt acccgtacgg gcatgagccg tagccgtacg gacatgggcc 40620 ttacccctac ggacacgagc atccgcaccc gcgtccacgc ccgcacccgc acccgccgac 40680 gactcggcgg gccgaatgtc ggtggccggc acaaccacca gtccgggtac gggcgttccc 40740 gcagtcaggg cagtgcgcag ggcggcgagg tcggcatggg cggcgggctc cgcgccgggc 40800 agggcgcgca aggtcgcgca ctcctccgtc gcagcctgtt ccgcagctgt ttcgcccgcg 40860 gcgggtccga gcaccgtcca gccatgggcg ccgggggtgt cggacctctg cggtactggc 40920 tgccagtcga cgcggtacag cggttccggc gcgccggccg tgcccagggc caccgggcgc 40980 agcagcagtg cgtccagggt gaggacgggg gcgcctgccg gatcggcggc ccgcaccgag 41040 aaggctgatt cggcgccgct gcccgccggt gccagcctga cgcggagcgt ctcggctcct 41100 gtggcgtgga gcgcgatgcc ctgccaggag aacggtgcca acgtggtgcc gcccgtgtcg 41160 ggcagcaacc caccggcccg ccatgggtgg agggccgcgt cgaagagtgc gggatggata 41220 ccgaaaccgt caccggccgt gcccgtcgcg gacagccgca cctcggcgaa gagctcgttg 41280 ccgaggcgcc atgccccgga cagtccgctg aaggccgggc cgtagtcgta gccgtccgcg 41340 gcgaacccct catacaactc cccgacgtct accggttcgg cccccggcgg cggccaggcc 41400 ccggcggccc aggccgtgtc cggaacggcc ggctccgcgg gcgcgagcac gccttccgcg 41460 tgtttggtcc actccggttc ctcgccgtcc caccccggtg tctcggggcg tgcggcaagt 41520 gcgacagcgc gccggccctg cccgtcggct gcctcgacca gcacctggag tcgcagtccg 41580 ccctgttcgg ggaggagcag gggcgcatgg agcgtcagct cctcgacgcc tcccgcgccc 41640 acctcttcgg cggcccgcag caacaggtcg gcgatcgccg tcccggggag cagcaccgtg 41700 ccggagatgg cgtggtcggc cagccacggg tgggtggaga gcgccaccct gccggtgagg 41760 agcaacgcgc cggagccgac tatcggcgtg gcgccgctga ggaacgggtg gtccttccat 41820 tccagcccga agcgggcagc ggccgaggag ccggtggagc cggacaccga gcccgtcgcc 41880 cagtagccac ggcgttggaa ggggtaggtg ggcaggtcga cccgccggcc gccgaaaccc 41940 gaatggaggg cagcgacgtc gagttcggca tcccgcgtat acagcgtggc gagtgcggtg 42000 gtgaaggtct ccagctccgg ccggtcacgc cgcagtaccg gcacgaaagc aagatcaccc 42060 tcgtccccgt cgagacactg ccccgccatc accgtcagaa cagcatgcgg acccacctcc 42120 acaaacgtat ccacacccac atcacgagca gcccccacac catccgcgaa ccgcaccgcc 42180 tcccgaacat gccgcaccca gtactccgga tcccccaact catccaaacc cgcaaccgca 42240 cccgtcacac tcgacaccac cgccacacca gaacgaggcc ggtgaaactc caccgaagca 42300 gcaacccgac gaaactcctc caacatcgga tccatcaaca ccgaatgaaa cgcatgcgaa 42360 acctccaacc acctgcactc cacaccacga cccaccaaac ccgccaccac accatccagc 42420 acccccgcct cacccgacag caccaccgac gccggaccat tcaccgccgc aaccgacacc 42480 cgaccaccca acccagccac caaacccgcc agctcggcct cagacgcccc caccgacacc 42540 atcgccccac ccacaggcaa cgcacccatc aaccgaccac gcgccaccac caaccgcacc 42600 gcatcagcca acgaaaacac acccgccaca tacgccgcag ccacctcccc caccgaatga 42660 cccaacacca ccgacacacc cacaccccga gcctccaacg cccggaacaa cgccacctcc 42720 aacgcaaaca acgccggctg agcaaactcc gtacacccca acaaccccgc atccacactc 42780 cccgcctccg caaacatcac ctcacgcaga gaccgacccc ccacctcccc cacaaccccc 42840 aacacctcat ccaacacacc cgcaaacacc ccacccgccc catacaactc acgccccata 42900 ccaacccact gcgcaccctg acccgtaaac aacaccccca cccgacgccc ccgcaccgcc 42960 gaaccccgca ccacacccga cgcggcaccc cccgcagcaa ccacacccgc cgccacagca 43020 tccagaccgg ccagcagctc cccacgctcc cgaccgacaa ccaccgcacg ctcaccgaac 43080 gacgcacgcg acaccacaag cgaatgcgca acatccaccg gatcagcacc cacacgctcc 43140 acgtgctccc gcaaccgcac cgcctgcccc cgcaacgcct cctccgaacg ggccgacacc 43200 ggccacgcca gaaccgaaga ggactcagcc gcagcagtga caacagcctc ggcttcggcc 43260 gactcctcga ccgacggttc ctcgatgacg acatgggcgt tcgtcccgct cacgccgaag 43320 gcagaaacag ccgcccgacg cacccggccc gcccgccggg gccaggacct ggcctcggtc 43380 agcaactcca ccgcccccga accccactcg accctcgacg acggagcatc cacatgaaga 43440 gtgcgaggca acgacgaatg ccgcatcgcc tccaccatct tgatcacacc acccacaccc 43500 gcagcagcct gagcatgccc gatgttcgac ttcaacgacc ccaaccacaa cggatcaccc 43560 acccgctcac gcccatacgt cgccagcaac gcacccgcct cgatcggatc ccccaacgcc 43620 gtacccgtac catgcgcctc caccgcatcc acatcccccg gagccagccc ggcatcagcc 43680 aacgcctcac ggatcaccct ccgctgggcc gcaccactgg gcgccgtcag accgttactc 43740 gcaccatcct gattgaccgc actcccccgc accaccgcca gcacccgatg cccataccga 43800 cgagcatccg acaaccgctc caccaacaac acaccaacac cctcggccca cacagtgccg 43860 tccgcaccct ccgcaaacgc cttgcaccgc ccgtccgacg ccagcccacg ctgccgcgag 43920 aactccacga acaccgtcgg cgtcgccatc accgtcaccc caccggccaa cgccatgtca 43980 cactcacccc gccgcaacga ctgcaccgcc agatgcaacg ccaccaacga cgacgaacac 44040 gccgtgtcca ccgtcaacgc cggcccctcc aaccccaaca cataagcaac ccggccggag 44100 atcacgcttc cgagcgtccc cgtgagcaca tgcccgccgt aggtttcggc ggcgtccccc 44160 aactggcttg cgtagtcctg ctgggagatg ccggtgaaga ctccggtacg ggtgccgcgc 44220 agcgcgtccg gcacgatccc ggcccgttcc aacgcctccc acgacgtctc cagcaacaac 44280 cgctgctgcg gatccatcgc cgccgcctca cgcggcgaaa taccgaagaa ctccgcatcg 44340 aactcggccg ccccgtgcag aaacccgccc tcccgcacat aactacgacc caccgcctcc 44400 ggatcggggt cgtacaaccc ctcgacgtcc cagccacggt cgacagggaa cggagagagg 44460 gtgtgcccgt cttcggccac caggcgccac aggtcctccg gcgacgacac gccgcccggg 44520 tagcggcacg ccatgcccac gatcgcgatc ggctcgcgct cgtcggccgt ggcccgggcg 44580 cgggtgtccg cgacaggctc cgcttcgctg tcggtaccga acagttcgtc gtgcagatgg 44640 gcggccaggg aggtcgggtt ggggtggtcg aagagcaggg tgctcggcag gttcagcccg 44700 gtggcagcgg tcaggcggtt gcgcagttcg agaacggtga gcgagtcgaa cccggcggac 44760 cggaacgcga tctccgggtc gaccgcgtcg gccgaggcgt ggcgcaggat ctcggcggcc 44820 tcggagcaca ccaggtcgag cagggcccgt cgccgttccg tcgacgaggg gccgacggag 44880 agccagggtc ggccttcgtc cgctccggct ccgcttccgc ccggcccacc gtggcccggc 44940 cgcgtccccc gggggagagt ggcacggcct tgcgcggcac gggcggaacg cgctgagcgg 45000 gcggcgggaa caccgtcgaa aagtgcccag gtgcggcggg tgacggaacg cccgacgaag 45060 gtttcccagt ccacatcggc gacgatcagc gaggtcgcga cggccgcaga ggccccggcg 45120 gcagcggagg tcccaccggc gccgaccgcg tcgtccagta cgtcgagcgc gtgctcggga 45180 tccagggccg cgacgccgtc ccgctcgaag gacttcgtcg ccgttccgga cgccatcccg 45240 gctccggccc acgggcccca ggcgatcgag gtggcacgcc ctccccgggc ccggcgccgg 45300 tgcgccaggg cgtcgagcgc ggcattggcc gccgcgtagg cggcctgccc cccgttgccc 45360 cacactccga cgatggagga gaagagaacg aaggcgtcca gcgggaggtc ggcggtgagc 45420 tcgtccaggt ggcgggccgc agtgaccttg gcacgcagta cggcgtctat ccggtcggag 45480 gtgagcgagt cgagcacacc gtcgtcgagc acgcctgccg cgtgcagtac ggcggcgagg 45540 ggccggtctt cgggaatgcc cgcgagcagc gcggcaagcg cgtcccggtc ggcgacgtcg 45600 caggctgcga cggtcacttc ggtaccgagg gctgtcagct cctcgacaag ttcgcccgct 45660 ccggggccgg ccgccccgcg ccggccgacc aggagcagat gcggggcgcc cgcccgggcg 45720 agcctgcggg cgacctgcgc gcccagggcg ccggtgcccc cggtgatcag tacggtgcct 45780 gaggaccgcc ggtttcccgg cacgactccg tcgggcgtgt cgccctgcgc gtcccgggcg 45840 gcggcggtgg tggcggcgcg gacggggacg gggaccacgc ggcggacatg gactccggag 45900 ggccgtaccg cgaactggtt gtcctcgccc tcggcgagca gcgtcccgac gaacgcacgg 45960 agcgcggcag gcgacggctc cccgggcagg tccgccaaac cgccccagcg ctgggcaagt 46020 tcgagtgcgg cgacctgccc cagcccccag agctgagcgc ctgcgacgga aggggcctcg 46080 cccggctgag cagccaccgc gtcgcgcgta gtgatccaga gcggggcgtc gggtcccgcc 46140 tcgcccaggg cctggatcag cgcgacggcg tcggccgtgt ccggctcggc cggggcgagc 46200 cacaggacgt gcgtgctgcg tgcggcaccg tcaccggcgg cccgcagcag gtctgcggcc 46260 gcctcccgac cggtaccgac cggcacgaca gcggtgtgga cctcggtgcc gcgcacggcg 46320 agttcacgcg cgatcgcggt ggcgagcccg gagtccgtcg tgtcgtcgtc cgaggccagc 46380 agcagcatac gacccgccgg ccgggggact ccgcagccga cggcggcggg ctgccaggtg 46440 acgcggtagc ggagcccggc cgtcgccgaa gtcacccctt gagcagcggt cggaacgtcc 46500 tcggacgaac cggcggccat ggcggtgggc actgcggcgg gggcggggtc cagccagaaa 46560 cgggcgcgct ggaaagggta tgtgggcaga tcgatgcgtc gtgcgtccct cttccgattc 46620 ggcgcgtccc agtcgatctg ggcgccccgg gcgtagaggg tggcgagtgc ggtggtgaag 46680 gtctccagct ccggccggtc acgccgcagt accggcacga aagcaagatc accctcgtcc 46740 ccgtcgagac actgccccgc catcaccgtc agaacagcat gcggacccac ctccacaaac 46800 gtatccacac ccacatcacg agcagccccc acaccatccg cgaaccgcac cgcctcccga 46860 acatgccgca cccagtactc cggatccccc aactcatcca aacccgcaac cgcacccgtc 46920 acactcgaca ccaccgccac accagaacga ggccggtgaa actccaccga agcagcaacc 46980 cgacgaaact cctccaacat cggatccatc aacaccgaat gaaacgcatg cgaaacctcc 47040 aaccacctgc actccacacc acgacccacc aaacccgcca ccacaccatc cagcaccccc 47100 gcctcacccg acagcaccac cgacgccgga ccattcaccg ccgcaaccga cacccgacca 47160 cccaacccag ccaccaaacc cgccagctcg gcctcagacg cccccaccga caccatcgcc 47220 ccacccacag gcaacgcacc catcaaccga ccacgcgcca ccaccaaccg caccgcatca 47280 gccaacgaaa acacacccgc cacatacgcc gcagccacct cccccaccga atgacccaac 47340 accaccgaca cacccacacc ccgagcctcc aacgcccgga acaacgccac ctccaacgca 47400 aacaacgccg gctgagcaaa ctccgtacac cccaacaacc ccgcatccac actccccgcc 47460 tccgcaaaca tcacctcacg cagagaccga ccccccacct cccccacaac ccccaacacc 47520 tcatccaaca cacccgcaaa caccccaccc gccccataca actcacgccc cataccaacc 47580 cactgcgcac cctgacccgt aaacaacacc gccgtcccac ccgaaacagc cgtgccccgg 47640 acggtcttcg gcctcgtgtg tcccgcggcg agcgcgtcca ggcctgccat cagctccgca 47700 cggtcgccac cgacgaccac cgcacgctca ccgaacgact cacgcgtcac cgcaagcgaa 47760 tgcgcgacgt ccaccggatc ggcgcccaca cgctccacgt gctcccgcaa ccgcgccgcc 47820 tgcgcccgca acgcctcctc cgagcgggcc gacaccggcc atgccagagt cggtgcgagt 47880 tcggctgtgg gagcggtgac agtcggcggc tcggtgggcg tctctgccgg cgcctcctca 47940 atgaccaggt gggcgttggt gccgctgatc ccgaaggagg acaccgcggc ccgccgcggg 48000 cggcccgcgc gctccggcca ccggcgcgcc tcggccagca gttccaccgt gcccgacgac 48060 cagtcgacat gtgtgctggg ccggtccgcg tgaagcgtcc gcggcagcgt gccgtgtcgc 48120 atggccagca gcatcttgat gacgcctgcg gccccggcgg cggcctgggt gtgcccgacg 48180 tttgacttca gcgaccccag ccacagcggt tctcccaccc gctcacgccc gtacgtggcc 48240 agcagcgcgc ccgcctctat cgggtcgccc agcgccgtac ccgtgccgtg cgcctcgacg 48300 gcgtccacat cgcccggggc gagtccggcg tcggccaggg ccgcccggat gacgccttcc 48360 tgcgcggaac cattgggcgc ggtgaggccg ttgctggcgc cgtcctgatt gaccgcactg 48420 ccccggacga ccgccagcac ccggtgacct gcgcgccggg cgtcggagag ccgctccagt 48480 gccagtacgg caacgccctc ggaccaggcc gtaccgtcgg catcggcgga gaacggcatg 48540 cagcggccgt cgggggccag cccgcgctgc cgggagaact ccacgaacat gccgggcccg 48600 gacatcaccg tggcgccgcc cgccagagcc agtccgcact cgccccggcg cagcgcctgc 48660 acggccaggt gcagcgccac cagagacgag gaacatgcgg tgtcgacggt gagcgccggt 48720 ccgcgcgtgc cgagggtgta ggcgatccgg ccggaggcca cgctcgccgt ggtgccggtg 48780 agcagatacc cctcgtatcc gtccgctcct tcgtgaagcc tcggcccgta ctccggtgcg 48840 acggcgccga tgaacacgcc ggtgtcgccg ccgcgcagcg actcggggag cactccggcg 48900 tcttcgagcg cctcccacga ggtttccagc agcagccgct gctgcgggtc catggcggtc 48960 gcctcacgcg gcgagatgcc gaagaactct gcgtcgaact cggccgcctg gtgcaggaag 49020 ccgccctgtc gcacgtaggt cttgccgggg acgcccggtt cggcgtcgta cagcccgtcg 49080 aggtcccagc cgcggtcggc ggggaaggac gagatcgcgt cggtgccgga cgccagcagg 49140 tcccagaggg cggcccgcga gtcgacgccg ccggggaggc ggcaaccgac gccgacgatg 49200 gcgatcgggt cgtcgtcccg tgtgccgccc cgggcggccg ccgccccgac cgcctcgtgc 49260 tcgccggggt gcgcgctctt tgtcccgtgc agtgcggcca ccaggtgttc ggcgacggca 49320 cgcggggtgg gcaggtcgta gacgagcgtg gcggcgaggg tgagccccgt ggcccggttc 49380 agcaggtcat ggagctcgac cgcggtggct gattccaggc cctgggaggt gaaggtgcgg 49440 tcgagcgcga tctcgtcggg gtcgtcgtgg cccaggacgg tcgcggtggt ctcgcgtacc 49500 agacggacga gctgctcggg agacatcggc tccggggacg ccgtgagcgg ttcgtcgtcc 49560 gggtccctga ggggcgcctc ggtgctctcc gggggcgcgg tgttccccgc ggcgtcggtg 49620 gtggtcaggc ccggcccggc gtcggccgcg attccacggc tcagcgccgg cgaccagtga 49680 gtacggcgtt ggaaggggta ggtgggcagg tcgacccgcc ggccgccgaa acccgaatgg 49740 agggcagcga cgtcgagttc ggcatcccgc gtatacagcg tggcgagtgc ggtggtgaag 49800 gtctccagct ccggccggtc acgccgcagt accggcacga aagcaagatc accctcgtcc 49860 ccgtcgagac actgccccgc catcaccgtc agaacagcat gcggacccac ctccacaaac 49920 gtatccacac ccacatcacg agcagccccc acaccatccg cgaaccgcac cgcctcccga 49980 acatgccgca cccagtactc cggatccccc aactcatcca aacccgcaac cgcacccgtc 50040 acactcgaca ccaccgccac accagaacga ggccggtgaa actccaccga agcagcaacc 50100 cgacgaaact cctccaacat cggatccatc aacaccgaat gaaacgcatg cgaaacctcc 50160 aaccacctgc actccacacc acgacccacc aaacccgcca ccacaccatc cagcaccccc 50220 gcctcacccg acagcaccac cgacgccgga ccattcaccg ccgcaaccga cacccgacca 50280 cccaacccag ccaccaaacc cgccagctcg gcctcagacg cccccaccga caccatcgcc 50340 ccacccacag gcaacgcacc catcaaccga ccacgcgcca ccaccaaccg caccgcatca 50400 gccaacgaaa acacacccgc cacatacgcc gcagccacct cccccaccga atgacccaac 50460 accaccgaca cacccacacc ccgagcctcc aacgcccgga acaacgccac ctccaacgca 50520 aacaacgccg gctgagcaaa ctccgtacac cccaacaacc ccgcacccac actccccgcc 50580 tccgcaaaca tcacctcacg cagagaccga ccccccacct cccccacaac ccccaacacc 50640 tcatccaaca cacccgcaaa caccccaccc gccccataca actcacgccc cataccaacc 50700 cactgcgcac cctgacccgt aaacaacacc gccgtcccac ccgaaacagc cgtgccggtc 50760 cgcactcccg cagaggtctt accgcgagcg aacgcgtcga gggaggcggc gagttcctct 50820 cggtcgccgc agcgcagtgc ggcgcggtgc tcgaagagag tgcgcgtggt ggccagggag 50880 taagcgatgt cccgcgggtc cgcgccggtc cggcccaggt ggtcgtgaag ccgcgcggcc 50940 tgcgcccgca gcgccgcgcg ggagcgggcc gacagcagca ggggcggggc cgggtgcggg 51000 gcggcggctt cggaggccga cgacgggatg gcgtccggtc cggccggggc cggctggggc 51060 aggtgctcca gcaccacatg gcagttggtg ccgccgatac cgaacgagct gacgcccgcc 51120 agcaggggtg cgccgctcgg gccggggtgc agttcggtcg gggccgtctg caccttcagc 51180 cggagccggt ccaaggggat ggcgggattg ggggtgtcga agttgagcga gccgggcagg 51240 gtgcgttccc gcaggcagag cacggccttg accagtcccg cgatgcccgc ggcgccctcc 51300 aggtggccga tgttggtctt caccgacccc accaacaagg gagtgtccgc cgaccgtccg 51360 gagccgtgga ccgcgccgag ggcgtgcgcc tcgaccgggt cgcccacggg ggtgcccgta 51420 ccgtgcagtt cgacgaagtg cacctcagcg gggtcgaccc cagcctgggc gcaggcggac 51480 cggagcaccg cttcctggcc ctcacggtca ggggcggtca gcccggggcc gccgccgtcg 51540 ttgccgatgg cgacgccgcg caccacgcag tacacggggt cgccgtcggc cagggcgtcg 51600 gcgaggggtt tgagtacgac ggcggcgccg ccctcaccgc gcacatagcc gttggcgcgg 51660 gcgtcgaagg tgtggcagcg gccgtcggga gacagcgcgc cgagccgttc catggcggcc 51720 gaaccctcgt cggcgaggat caggttgacg cccccggcga cggcgatgcg ggaggtgccg 51780 gctcgcaggc tctcgacggc gagggccacg gcgaccagtg acgacgactg cgcggtgtcg 51840 accgcaaggc tggggccgcg cgttcccagg acgtaggaga gccggttggc gagcatggcc 51900 cgctggaggc cggtggcggt gtgggcgcca atcggcgcgc cggcccggtg gagcagcgtg 51960 gcgtagtcgt cgttcatggc ccccacgaag acgcccaccg cctcgcctcg cagcgaaccc 52020 gggacgattc cggcgtcctc cagtgcttcc cagccgagtt cgagcatcag gcgctgttgc 52080 gggtcggtct cggcggcctc gcgcggtgac atgccgaaga acgcggcgtc gaagtcgccg 52140 accgcctcga tcatgccgcg ccgacgaccg tctgcggcac ggcctatcgc ttccgttccg 52200 tcggtcagca gtttccagaa ttcctggatt cccggtgcgc tgggaaatcg gcacgacatt 52260 ccaacaacgg caacggcatt ggaccggtcg tcacttcggg aaatcacgag atcttcagac 52320 acctgcatcc ctcatatgct cgccatgcca tgtcgcggaa tgttctgccg tttctggatc 52380 ttcacgagcg tacagcggac gaacagttgg gcgacaggaa cgaccaacga acggcaatca 52440 attgtgtcaa gttccgcgga ttcgccgcgg attctcatga cacgggtcgc cgacgactgt 52500 ggactgggat cttccggaag gctttccggc gaaaagggag cggcattgtg tcaggtctgt 52560 attgccgagc tgcggcgact gcgcgcaagc accccgcccg ccggggccgg agtcggcgcc 52620 ggcgcccggt cgggtgcagt gactcacggc ctgcgcccca agggccgacg gcccgctcac 52680 gcggtcaccc ggcatttccc cgacctggcc cctgccttgc cccagccccc tgcccctggc 52740 tgggcctcgg tgcggaattc cgcgaactcc ttcgcgaatc ctctgacaca tgaactcgca 52800 catgaacgtg cacgcgaact cctgggtgaa cgcgcacgtg atctcccagg tgaaccgcga 52860 agctttcagc accgggtcgg ctcggcacaa ccgccccgcg gtgaatatgt caggttcccc 52920 gcgccgctcc gtccgctccc gagcggcatc tcgacaaggt tccccggacg gggagtcatt 52980 gtgtcaggtc cgccttgctg gcgttcttca ccgattcata agctctgccg ggatcgaggg 53040 accgatactg ccgtgtcgcg cgttcggtcc gcacaccgat tttcaaggag ttcgactgat 53100 gggtgaggct gtgtcgggac cgatggagtt gagcaaggat gcggatgccc gggggctgct 53160 ggactggttc gctttcaaca ggacacgtca tccggtgttc tgggacgagg gccggcaggc 53220 gtggcaggtc ttcggttacg acgactacgt gacggtgtcg aacaacccgc agttcttctc 53280 gtcggacttc aacatggtga tgccgacgcc gcccgagctg gaaatgatca tcgggccggg 53340 cacgatcggc gcgctggacc cgcccgcgca cggaccgatg cgcaagctcg tgagccaggc 53400 cttcactccc cggcggatcg cccggctgga acccagggtg cgcgcgatca ccgaggaact 53460 cctggacaag gtacgggaac agaacgtcat cgatgccgtc ggcgacctct cctacgcact 53520 gccggtcatc gtgatcgccg aactgctggg cgtacccacc ggcgaccggg acctgttccg 53580 ggagtgggtc gacaccctgc tgacgaacga gggcctggag tacccgaacc tcccggacaa 53640 cttcaccgag acgatcgcgc ccgcgctcaa ggagatgacc gactacctcc tggaacagat 53700 ccacgccaag cgggaagccc cggccgacga cttgatcagc ggtctggtcc aggccgagca 53760 ggacggccgc cggctgaccg atgtcgagat cgtcaacatc gtcgcgctgc tgctgaccgc 53820 cgggcacgtc tcctccagca ccctgctcag caacctcttc ctcgtcctgg aggagaaccc 53880 gcaggcactg gaagacctgc gggccgatcg cacgctggtg cccggcgcga tcgaggagac 53940 actgcgctac cgcagcccct tcaacaacat cttccgcttc gtcaagcagg acaccaccat 54000 cctcggcccg ctcatggaga agggccagat ggtgatcgcg tggagccagt ccgccaaccg 54060 ggacccccgg cacttccccg acccggacac cttcgacatc cgccgctcgg acggcacccg 54120 gcacatggcc ttcggccacg gcatccacca ctgcctgggc gccgccctgg cccgcctaga 54180 gggcaaggtc atgctcgaac tcctcctgga gcgggtcgac ggcttccgca tcgaccacga 54240 aaacacgctg ttctacgagg ccgaccagct cactccgaag tacctgcccg tccgcgtcga 54300 ctggaactga acccgagggt tccgtccccg ggccagggcc gtcccgagcc ggccgtggac 54360 ctcacgaccg cccgataagg agcgccgcca tcgccgagaa cacagccgag cctcccgccc 54420 ggcgggtcgg caggatcaag ccgtgccggc tgatcaggct cgagcagcac atcgacccgc 54480 gcggcagcct gtccgtggtc gagtccggcg tgaccgtgga cttccccgtc caacgcgtct 54540 actacatgca cggccagacc cagtcctcac ccccacgcgg cctgcacgca caccgcaccc 54600 tggaacaact cgtcatcgcc gtccacggcg ccttctccat caccctcgac gacggcttcc 54660 agcacgccac ctaccgcctc gacgaacccg gagccggact ctgcatcggc cccatggtct 54720 ggcgcgtcct caaagacttc gcccccgaca ccgtcgccct cgtcctcgcc tcacagcact 54780 acgaagaatc cgactactac cgcgactacg acaccttcct gcacgacgca cggagcctca 54840 catgacaatc cccttcctcg acgcaggcgc cggctaccgg gagttgcggg ccgacatcga 54900 cgcggccctc cagcgggtgt ccgcctccgg ccgctatctg ctcggcgctg aactggaggg 54960 tttcgaggag gagttcgccg cgtactgcga caacggccac tgcgtggcgg tcggcagtgg 55020 ctgcgacgcg ctggagctgt ccctgcgcgc gctggacatc ggtcccgggg acgaggtggt 55080 ggtgcccgca cacaccttca tcgggacctg gctggccgtg tccgccaccg gggcgcagcc 55140 ggtggccgtc gatccgacgc cggacgggct ttccctggac ccggcgctgg tggaggcggc 55200 cgtcacccct cgcaccaagg ccctgatgcc cgtacatctg cacggacacc cggccgatct 55260 ggacccgctg ctggcggtcg ccgaacggca cggcctggcc gtggtcgagg acgccgcgca 55320 ggcgcacggc gcccgttacc ggggccgccg gatcggctcg ggccacgtgg tcgcgttcag 55380 cttctacccc ggcaagaacc tcggcgccat gggcgacggc ggcgcggtgg tcacccggga 55440 cgccggagtg gccgatcgga tccggctgct gcgcaactgc ggctcccggg agaagtaccg 55500 gcacgaggtg cgggcgacca actcccggct cgacgagctc caggccgccg tgctgcgcgc 55560 caagctgccg cggctcgacg cgtggaacgc ccgccgggcg cgcacggccg aacgctacac 55620 ccgggccctg ggttcccttc cgcagatcgc cgtccccgtc accgctcgct gggccgaccc 55680 ggcgtggcac ctgtacgtga tccgctgcgc ggaacgcgac gagctgcgcc gccggctcga 55740 gcgggccggg gttcagaccc tgatccacta ccccgtaccg ccgcaccggt ccccggccta 55800 cgccgacgcc ccggccgggg ctccggccgg ggcccacccg cgcagtgaac gcctggcggc 55860 gcagagcctc agccttcccc tgggaccgca cctcggggac gacgagtccc gtgccgtcgt 55920 ggcggcggtc cgggcggcgg ccgcggggct ggcggcgtac ccgacgccgg acggcacgcc 55980 gcgcacgccg cgcacgacgc cggacggcca gcgttttcct ctagcgacgg agaaacgatg 56040 accgaggtca tgtcagggcg ttccggaatg aaagggatca tcctcgcggg cggcggaggc 56100 acccgcctgc gccccttgac cggcacgctg tccaagcaac tgctgcccgt ctacgacaag 56160 ccgatgatct actacccgct gtccgtcctg atgctgggcg gcatccgcga gatcctcgtc 56220 atctcctcca cccagcacat cgaactcttc cagcaactgc tgggcgacgg ctcccggctc 56280 ggcctggaca tcacctacgc cgaacagccc gagccccagg gcatagccca ggccctcacc 56340 atcggcaccg accacatcgg tgactccccg gtcgcgctca tcctgggcga caacatcttc 56400 cacggccccg gcttctcctc cgtactccgg ggcagcatcc gccacctcga cggctgtgta 56460 ctgttcggct acccggtcag cgacccgcag cgctacggcg tcggcgagat cgacgaccag 56520 ggcatgctgc tgtccctgga ggagaaaccc gcccggcccc gctccaacct cgccgtcacc 56580 ggcctctacc tctacgacaa cgacgtcgtc gacatcgcca agaacatccg gccctccgca 56640 cgcggcgaac tcgaaatcac cgacgtcaac caggtctacc tggagcagaa acgcgcccgg 56700 ctgatcgaac tgggccacgg cttcgcctgg ctcgacatgg gcacccacga ctccctcctc 56760 cagggcggcc agtacgtcca actcctcgaa caacgccagg gagtacggat cgcctgcatc 56820 gaggagatcg ccctgcgcat gggcttcatc gacgccgaca ccctctactg gctcggccgc 56880 gagctgggca cctccggata cggcgcctac ctgatggagg tggccaccca tgcaggcgcc 56940 gcatgagtcc ccgcaccggc ccacccgctt cgccgacggt cggcagccgg cccgtatcct 57000 cgtcaccgga ggcgccggct tcatcggctc gcgcttcgtg aacgccctgc tggacggctc 57060 gctgccggag ttcggcaagc ccgaggtgag ggtgctcgac gcgctcacct acgcgggcaa 57120 cctggccaat ctggccccgg tgggcgactg tccccggctg cggatcttcc agggggacat 57180 ctgcgaccgc agcgcagtcg cccaggccat ggcgggggtc gatctggtgg tgcacttcgc 57240 ggccgagtcg cacgtggacc ggtcgatcga cgacgccgac gccttcgtgc gcaccaatgt 57300 gctgggcacc caggtcctcc tccaggaggc gctggccata cgccccggcc tgttcgtgca 57360 cgtttccacg gacgaggtct acggctcgat cccggtgggg tcgtggcccg aggaccaccc 57420 gctgagcccc aactccccct atgcggcctc caaggcgtcc tccgacctgc tggcactggc 57480 ctaccaccgc acgcacgggc tgccggtgtg cgtcacccgt tgttccaaca actacgggcc 57540 gtaccagtac ccggaaaaga tcatcccgct gttcaccagc aacctgctcg acggcaggac 57600 cgtcccgctg tacggggacg gcggcaaccg gcgcgactgg ctgcacgtga acgaccactg 57660 ccggggcatc gccctggtgg cccggggcgg tcgccccggc gaggtctaca acatcggcgg 57720 cggcgccgag ctgaccaacg tcgagctcac cgaacgtctg ctgaagctgt gcggagccga 57780 ctggtcggcg gtgcggcagg tgccggaccg caagggccac gaccagcgct actccgtcga 57840 ctacaccaag atcgccaccg agttgggata cgcgccgcgg atcaccatcg acgagggact 57900 ggagcagacc gtgcgctggt accgggagaa ccacgcgtgg tggacgcctg tgaagagggg 57960 acgatgacgt tgatgtccgc atccgtggac ccgcgtgacc tttggctccg ccggtaccag 58020 ccttccgcgt cgcccgccgt gcggctggtg tgcttcccac acgcgggcgg ctcggcgagt 58080 tccttcctgc cgttcacccg gcaactgccc gacagaatcg aggtgtctgc cgtccagtac 58140 cccggacgcc aggaccgcag gagcgagcct ctgatcgaca ccatcgaggg cctggccaag 58200 cccctggccg acatgctgga gacacgggcc gggccccctg tggtgctgtt cgggcacagc 58260 atgggcgcgc tggtcgcgta cgaggtcgcc cgcgtgctcc agcagcgggg agcggccccg 58320 gtgcgcctgg tggtctccgg acgccgggcc cccgcctcgg accgaccgat gaccgtgcac 58380 ctctacgacg acgaccggct ggtcgaggaa ctccgcacgc tcgacggcac cgacagccaa 58440 gtgttcgccg atccggagct gctccagctg gtgctgcccg cgatccgcaa cgactaccgg 58500 gccgtgggga cctacaccca ccgtccgggg gcgcccctgg actgccccct caccgtgttc 58560 accggtgccg acgaccccac tgtgaccgcg gccgaggcgg cggcctggca cgaggtggcg 58620 gcggccggcg ccgagatgcg gaccttcccc ggcggccact tcttcccgta ccagcggacc 58680 gcggaggtgt gcggagccct ggtggacacg ctcgcgccgc tgctctcgac cgggacgcgc 58740 ggcgtccggc gggtccgccc cggggacgtc ggcacggtcg aatacgccgg ccaccggcgc 58800 accgcggaac gggtgctgct ctccgccgac acgctcgaca gtccggtcac ctcgctggcg 58860 gacgtgcccc gctggctgga ggcgtaccgc cgggcgcacc gcttccacgt cgagccgatc 58920 ccgttcgacc ggctccggcg gtggtccttc gagccgggca ccggcgacct gcggcacgag 58980 acgggtcgct tcttctccgt ggaagggctg cgcaccagct cggacgccga cccggtcgcc 59040 cgcgtccagc cgatcatcgt gcagcccgag gtggggctgc tcggcatcct ggcgcgggag 59100 ttcgacgggg tcctgcactt tctgatgcag gccaaaccgg agcccggcaa cgtcaacggg 59160 ctgcagctct cccccacggt gcaggccacc cgcagcaact tcgacgaggt gcaccacggc 59220 cggtccaccc cgttcctcga ccacttcatc caccgtcccg gccgacgggt cctgatcgac 59280 accatccagt ccgaacaggg cgactggttc ctgcacaagc gcaaccgcaa catggtcgtc 59340 gagatcgaca cggacatcga ggccgatgcc accttccgct ggctgaccct gggtcagatc 59400 cgcaggctga tgctccagga cgacctcgtc aacatggaca cccgcagcgt gctggcctgt 59460 ctgccgaccg cgcacggcgc gcccgacgac gacgaggact tcccggcggc gctccggcgc 59520 tccttctacg gggaggccgc accgctgcac gacctgcacg ccatcaccag ctgcctcacc 59580 gacgtccggg cactgcgggt gctgcgccag cagagcgtgc cgctcgacga cgcccgtcgg 59640 gacggctggg agcggaccga gagcacgatc cggcaccgca gcggtaagca cttcgagatc 59700 atggcggtgg aggtgacggc ggagcggcgc gaggtggcgt cgtggaccca gccgctgctc 59760 cgcccgtgct cccaggggct cgtggctctg atcacccggc ggatcaacgg ggtgctgcac 59820 gccctggtgg aggcgcggtc ggacgtaggc accctgaacg tcgccgagtt cgggccgacc 59880 gtccagtgcc ggccagccga atcggacggc atgtcgcccc cgtacctgga ccaggtcctg 59940 acggccggag ccgaccgcat ccgctacgac gtggtgcagt ccgaggaggg cgggcgcttc 60000 taccacgcgc gcaatcgcta catggtggtc gaggcggggc cggagctcga cacgggctgc 60060 ccgcccggct tctgctgggc gaccttcggc cagctcaccg aactgctcgc gcacggcaac 60120 tacctcaacg tcgaactccg caccctcgtc gcgtgcgcac acgcctccta ctgaatgcct 60180 acgaaaacta caccgcgggg gaatcggcac cacgcccgcc ggtcaaccat cggcaaagaa 60240 ggcagaggac cgttctcgca catcagcgac gtgcgggaag cgacggaacg cccggcacgg 60300 accgcgcaca attacgggag agaacctccg ggtatccgcg gataaccgct tcctcccaag 60360 ccttcctcac cccccgaagg accgtgcaag aaatcccgat ggccgacgac attcctttcg 60420 atcctccccg gatatggaga tcccgtgggc gagcgtgcga atatcgtgca cgggcacgta 60480 catcgccctg ctcgattcca gccaattcct gccatcggtc ccgcattccc actcctgcgg 60540 cgcgctcggt gccgtaggtc ccgcgccggt ggacacgcgg cttccgagac cgggcacatg 60600 ccggtggatg cgcgacttcc accaccggcc acacccggcg gatgcgcgat ttccacgagg 60660 tgaccgacag cgacttcacc ggaatggcgg cccgccgggc atcgccgcgc caccgctttc 60720 cggccgctcg ccccgccgcc gcccgggaca ccgcacggga cgggaagcga ccgcggcccg 60780 gcgtcgagcg aacctgccca agcccggacg agacagcgcg acgcgagagg tgaccatgat 60840 caatctcttt caaccccaga tgggtgccga ggaactggcg gcgatcgccg gggtcttcga 60900 cgaccaatgg ctcggtcacg gaccacggac caaagcattc gagtccgcgt tcgccgacca 60960 cctcggggtc ggccccgagc acgtcgtctt cctcaactcg ggtacggcgg gcctcttcct 61020 ggccctggaa tcgctcggac tgcagcccga cgacgaggtc gtgctccctt cgcccagctt 61080 cctcgccgca gcgaacgccg ttcagctgac gggagcgcgc ccggtcttct gcgacgtcga 61140 cccccggacg ctgaacccgg ccctggagca catcgagcag gccgtcaccg cgcgcaccag 61200 ggccgtcatc gcactccact acggcggata ccccggcgac atcgtccgca tcgccgagca 61260 ctgccggaac cagggcatca ccctgatcga ggacgccgcg tgttcggtgg cctcccgcat 61320 cgacggccga gtggtcggca ccttcgggga cctcgccatg tggagcttcg acgcgatgaa 61380 ggtcctcgtc accggcgacg gcgggatgat ctacgtcaag gatcccgggg cggccgcccg 61440 catccggcgc ctcgcctatc acggcctcac ccagtccagc ggcctgggat acgccagggt 61500 ctcggcgcgc tggtgggaga tggacgtccc cgagccgggc cgacgcgtca tcggaaacga 61560 cctcaccgcg gccatcggcg cggtgcagtt gcggcggctc cccgatttcg tggcccgccg 61620 caaggagatc gtcgccctct acgaaagcga actgcgcaca atggagggcg tgtcgacgcc 61680 gcccgcgctc ccggaaggac acgagtccac gcactacttc tactggatcc agctgccccc 61740 cggcgtccgg gaccgggtgg cgcgcgacct gctcaccgac ggcatctaca ccaccttccg 61800 ctacgccccc ctgcacaagg tgcccgccta cggtcacgcc ggacgcgaac tgcccggcgt 61860 ggagtgggcg tccgagcgga ccctgtgcct gcccctgcac ccgggcctgt cggacgccga 61920 cgtcctcacc gtcgtgtcct ccttgcgcaa agctctgaac gccggggcgc aggctcccgc 61980 ataacaggcg catacggtac ggcccctgcc cggcggttct ccgccgggca ggggccgttt 62040 cgcgtccggg acggtctccg tcgtcccgtc ggctcgctag gcgcgcgtgc cgaggaaaaa 62100 gccgggggag ccgttgcccg tctcgacgta ctcgacgtgc aggccggcct tgcggtacgc 62160 ggtctcgtac tccgcacggg agaacagcgt gaggtagtcc acctcgctgc ggtgccggat 62220 gccgtcggtg gtgtgcgcga tcaggtagtg gatttccatc cgggtcttct tgccctccct 62280 ggtcgagtgg gcgacgcggg cgacgccctg gtctcccgac tccgtcctga gggcgtgggt 62340 ggagacgtag ccgtccagga aggtgtcggg gaagtaccac ggttcgacgg ccaggacgcc 62400 gtccgcggag aggtgccggg acatggcggc gatcgcgtcc tccaggtcgg ccgcggtctc 62460 cagatacccg atcgaactga acatgcagac cacggcgtcg aacgtctcgc cgaggttgaa 62520 cgagcgcatg tcgccgcggt ggagggtcac atcggagagc cgctcctcgg cgcgggccgc 62580 catccattcg gagagctcca ggccgctcac acggtcgtag agcttggcga aggcctccag 62640 gtgcgtgccg gtgccgcagg cgatgtcgag caggctggag gcgttcggcg tgcgttcccg 62700 gatcaggccg gtgacccggg cggcctcgcc ggcgtagtcc ttgcggtcct ggtacagcag 62760 gtcgtagacc tcggccgcac tgtcgttctc gtacatggga atcctccggg ccgtgttggg 62820 gggggaaccg ttggtgtgtc gaagaggagt gcgccgtgcg gtcgggggca cgggcggcat 62880 tccgctgcgg aggccgtcgt tcggacgcgt cgtgcgcacg ccgaacccgc tatgcgcgta 62940 cgggagttcc atcgaccgaa gccgtgcggg tatccgaccc gcaccggtcc ttcgcggtga 63000 tctccgtacg gacacccaac agttcacgcc gagtcgaggt caaggaacgg cagcctggtc 63060 agtcaagtcc ggcggtccgc acttggggca gtgggcgccg acgcgccccg ggccccgggg 63120 cgggcgccgg tcgggccgtc ccgcggagcc ccattcccgt cctcccgcag aagggatgca 63180 gaatcggaca gccgacggct tgtttcaccg gaaaacgcgt ggtgcgcccc gagtcgccgg 63240 tagcttatcc accgttcgcc gaggcggttc aagtggcagc gttcaaccgc gatccggtct 63300 ttatggaatt catatctgcc cgctggcttg atgagtcggg cctcatgtcc ggaagtcgat 63360 cccggccggg agtgcgcggc gatccgcccg gacgccgaat gccgtggccg gcacccgtcc 63420 ggtaacgtcc tgcggggtac ggacggcggt ccggccgtcc atcagaatcg gacgaacggg 63480 atgaaatgtt atggcgaggg agcgaaagga agcgggtgcg gaggatttac cgcagcccgt 63540 tccaggaccc tcggcgatct agatcgggta ccctgatagc gtaataacct gtcattgtat 63600 tcgtaaagca cagggatggg ggcgcctgcg gcatgagtta cctggattat ggtgaagaag 63660 cgtctgaaga agacgagtcg gacgacgcac tcaccttcct cgaatttgtt gcccggtcgg 63720 ccccgcggag cgaatacgac cggctcatgg cgcgcgcgga acgcgcgggc gccgacgagg 63780 aacggatgcg tcggctggag cgcttcaacc ggctcgccct caccgcgcag tcgatgatcg 63840 agtaccgccg cgaccgggag gcggagctcg cggcgctggt cgacgccgcg cacgagttcg 63900 tcgccgccca gcagtacaag gacctgctcg aatccgtcgc ccgcagagca cggctgctgc 63960 tcaagctgga tgtcgcctac gtcagtctgc accaggagga cctgcaccac gaggaccggc 64020 ccggcacggt ggtgctgagc gccgacggca acgcggtcaa ggtcgccgac agctaccggc 64080 tgccggccga cggcgggctg ggcggcatgg tgcgcacctg ccacgctccc ttctggaccc 64140 ccgactacct cggggacagc agcttcgtgc acgtcgagac cgtcgacgac atcgtccgcg 64200 cggaagggct gcgcgcggtc ctggccgttc cgctgtgcgt cggcgacgac tcggtggggg 64260 tgctctacgt cgccgatcgc caggtccggc acctgacccc caacgaggtc accctgctgt 64320 gttcgctcgc cgatctggcc gccgtcgcga tcgagcgtat ccggctggtc gaggagctcc 64380 gcgacaccat cgggcggctg cgcgaggacg tcggtgaggc ccgcgccgcc ctcgcgggca 64440 cccgcaggtc cgccgacctc cagtcgcacc tgatcactca ggtcctcgaa aggcgcgggg 64500 ccgacgcctt actcgccgcc gccgccgaat ccctgggcgg cggcaccagc ctctgcagcc 64560 cgctcggccg gccgctcgcc gagtacggga acctgcgccc cgtcgccccc gccgacctgc 64620 gcgccgcctg ccgcagggcc gccgaaaccg gccgacccac ccccgtcgca ccggggtact 64680 ggacggtccc cctgtacccc ggggagtaca acgccggctt cctgctgacc gacgtcggac 64740 ccgaggcgga ccacacggtc gtaccgctgc ttcccatggt cgcccgtacg ctcgcgctgc 64800 atctgcgcat ccagcgcaac gactccacca aggcccagag ccaccaggac ttcttcgacg 64860 atctggtcgg ggcgccgcgc tcgcccgccc tcctcaggga gcgcgccctg ctgttctccc 64920 tcagcttccg ccgcccgcat gtcgtgctgg tggcgagcgg accccacgga gcctcggcgc 64980 ggctggagtc ctccggcgcc gactacgcga aggaactcgg cgggctgtgc agcgtacggg 65040 acggcgccgt cgtcctgctg ctgcccggcg acgaccccgt ggccgtggcg cagaccgccg 65100 ccccggaact caccgatcgg gtggggcacc cggtcaccgt gggggccgcg ggccccgcct 65160 cgaccgtcga cggcatcagc gacgcccacc gcgaggccgc gcagtgcctg gagacccttc 65220 gcgcgctcgg cggtgacggt ggcaccgcct gcgcctccga cctggggttt ctcggaatgc 65280 tcctggccga ggaaaacgat gtccccggct acatcaagac gaccatcggc cccgtgatcg 65340 actacgacac ccaccgcttc acggatctca tccccacgct gagggtgtat ctggagtcgg 65400 gcaggagccc cacccgcgcc gcggagacgc tgcgcgtgca ccccaacacc gtctcgcggc 65460 ggctggagcg catcggccaa ctgctgggag aggactggca ggggccggag cgggtgctgg 65520 acatccaact ggccctgcgg ctgtaccagg tgcgttcggc gctctcctcg cgctccgcgt 65580 ccgcctcgct ccccccgcgc ccggcgcccg cctcccggac cgtgctcgga tcgcagcgcg 65640 agtgagcgcg ggcggccagg cgatgcgcgg ccggacggcg cccggtggcc gcgccaccgc 65700 cgtggtcacc cggtgacgga ctcctggtgg ccgcgccacc gcccgtcctg cgacagccgc 65760 agcgcatggg cgatcgaggc cggcgtcacg tgccggtgcc ggccctggaa cgagcgcccc 65820 tcgaagtcac ggatgccgac gtccacgccg acccgggcga agtcggcgtc cacccggtcg 65880 gtcagcgccg ccagcggcag cagcgcccgg tgccccaacg ggccgaggtc ggtcagccac 65940 aggcttcggg tccggcttcg ggccccgatc gggtttcggc ttcggcgtcc gtttcgggtc 66000 ccggtgggga ttcggcttcg ggtcaagcgg agtagtgatc atcacgccct tcgcagggcg 66060 ctcgaattcc ggtgactgcg tgcgccacag ccttacggaa ttctccgggc cctcgcagac 66120 acaccgggca caccctttca gcgccgcccc ggctcccgcg attcactccg ggcccacggc 66180 ccgtctcgcc ctgaaaaccg gtggtcaact caccgtggcg accctctcga cggtggcggg 66240 acattccacc gaatggcacc gagaaacgac gccactgcac ccgtgctgcg gcattccctt 66300 ttccgtcgct ttggtcatgt gaggctccgt gcgtcgtgca ggaaggtgtc gtagtcgcgg 66360 tagtagtcgg attcttcgta gtgctgtgag gcgaggacga gggcgacggt gtcgggggcg 66420 aagtctttga ggacgcgcca gaccatgggg ccgatgcaga gtccggctcc gggttcgtcg 66480 aggcggtagg tggcgtgctg gaagccgtcg tcgagggtga tggagaaggc gccgtggacg 66540 gcgatgacga gttgttccag ggtgcggtgt gcgtgcaggc cgcgtggggg tgaggactgg 66600 gtctggccgt gcatgtagta gacgcgttgg acggggaagt ccacggtcac gccggactcg 66660 accacggaca ggctgccgcg cgggtcgatg tgctgctcga gcctgatcag ccggcacggc 66720 ttgatcctgc cgacccgccg ggcgggaggc tcggctgtgt tctcggcgat ggcggcgctc 66780 cttatcgggc ggtcgtgagg tccacggccg gctcgggacg gccctggccc ggggacggaa 66840 ccctcgggtt cagttccagt cgacgcggac gggcaggtac ttcggagtga gctggtcgcc 66900 ctcgtagaac ggtgaactcg atccggcgtt cggcttccgg catccgagcc cgtcgacgtc 66960 agcggaacat acgaagcacc gaggcagtcg gcaagacgga cgtgacacag tgggcgcctc 67020 tgtcggaagc ggcgcccgga cccggcgcac cgcaccggtg gacacgaatt tccgtaccgt 67080 cggcggaagt tgacggacgc ctcgcctttt ccgcacgaag gcgcgcgaag gcgcgcgaag 67140 ttccttggcc ggacgacagc gccgaccgcg acctgacatc cgttcatcgg caagtcctgc 67200 cgcttccgca ggcgcccggg ctcagggaac agcggtgcag ccagagcacc ggcccccgcc 67260 cgtcggcgcg gatcgccgtc gggcgggcgg gttttgagcc ttgaccgcgg ccccttcgga 67320 acgaggtccc gggcccgcgt gagggcgtgg ctcagcctgc gctgaactcg gcgatgcacc 67380 cgtggtccat ggcaagccgg gccccggtga accgggaccg catccggcgg tcgtgggtga 67440 cgacgaccac ggcgccccgg tagtccacga gtgcctgctc cagttcctcg accagcaccg 67500 gggtgaggtg gttggtgggt tcgtccagta gcagcaggtc catcgggtcg ctcaccagcc 67560 gggcgatctc gatccggcgg cgctgcccgt acgacaggtc cttcacccgt cgccgcaggt 67620 cggacgggct gaacaggccc aacgagagca gtttctccgc gtggtcctcc aggtagccct 67680 cccggccgtg ggcgaaggcc cgcagcaccg tgagctcggg cgaccagggc gtctcgtcct 67740 gccgcaggtg cccgactcgg cagccgacgc gcaccgagcc gctgtccggc gccagttccc 67800 cggagagcac ccgcagcaag gtggacttgc ccgcaccgtt gggtccggtg atcagcagcc 67860 gctcgccggg ccggatcttc agggagtcga cgtcgagccg gtccgcgacc cgcacgtcgg 67920 tgagttcggc caccgcctcc tccgcctccg ggcccgcggt gtcgatgcgg gcggcgaagg 67980 acagcgggtc cgcgggggcc agggccgggt tctcggtcag ctgcgccacg cgttgcttgg 68040 cgttgcggat ccgcaccatc gcgccgtggt cgcgtccgcg cctgcggtag gcgccgtggc 68100 cgaacacgga gagggacatc ttgcgcggga tgttgtccat ccgcgccacg ttggaggtga 68160 tcagcccctg gttgcgctca agttcggcac gccattcctc gtactcccgc agccgccgct 68220 cgcgttccac ggccttggcc gtcagataac cctcgtaacc gttgccgtag cgggtgacgc 68280 ggccggagtc gacctccagg atcgtggtgg tgagccggtc caggaacacc cggtcgtggg 68340 tgaccgcgat caccgtgccg cggtggccct gcaggtggtt ctccagccat tccatcgccc 68400 ggtcgtcgag gtcgttggtc ggctcgtcca gcagcaacag ttcgggcgcc gaggccaggg 68460 tcgccgcgag ggcgaggcgg gagcgctcgc cgccggagag ggttccgagc ttccggtcgc 68520 ggtccaggct cggcagtccg aggccgtgca gcgcgacctc cacgcgtacg tcggcctcgt 68580 aaccgccacg ggcctggtac tgctcgacca gaccggcgta gcgctggagg agggcggaca 68640 gctcccgttc ggaaccgtcc tcgtcgcgct cggtcagttc cgcctcgacc tcgtgcatcg 68700 acgcttcgag ctcgcgcagg tcggacaggg ccagatcgac ggcgtcttgg acggtggcgt 68760 cgagcggcag ttccaacgtc tgtgccagat agccgatgcc gccgggggcg accacggtga 68820 gcatgccgtt gtcgggctgc tcgcgcccgg cgaggacctt gagcagtgtg gacttgccgg 68880 aaccgttgtc gccgatcacg ccgaccttct cgcccggctt gatgctgaag ccgacccggt 68940 cgagtacgac acagtcgtgg tagcgcttga tgacgtcatg cagggcgaat tgcgcaatcg 69000 acacgtgtgt gtctcctgtt tcacgatgag gatgagtgaa tgcgtgagcg cgctcggcga 69060 aacggccgga agaaagcgac acaaacgcca ccacagcgga ctgaccgatg cagtggtgtg 69120 tcagcagcac gctgctggat gcggcaacgg agtccagctc aacgccgcgc atcctcatct 69180 atcacagaga tcccatgcga tgaactataa acgggccacc cgatgccggg caaggggatt 69240 cgggttcccc ggcccgacgt gatgcagtcg gaacgggatg atcgcccgtc cggcggtcgg 69300 gtgcctagcc tcgggaacaa ccacagcggt ctttcaggag ggctggccat gggcgagacc 69360 aagaaccgga tcaccgaact ggtccgcgcg taccaccggg aacaggcgac cgggaatttc 69420 gttcccggga cgacgcacgt accggtctcg ggcgcggtac tgagcgagga cgaccggttg 69480 gcgctggtgg agacggcact ggagatgcgg atcgcggccg gcccggcctc ccggagcttc 69540 gagcggcagt tcgcccggta cctcgggcta cggaaggcgc atctgaccaa ctccggctcc 69600 tccgccaacc tcctcgccct cagcgcgctc acctcaccgc agctggagga caggcggctg 69660 aaaccgggtg acgaggtcgt cacggtcgcc gccgggttcc cgacgacggt caacccgatc 69720 ttccacaacg agctggtgcc ggtcttcgtg gacgtcgaac tcggcacgta caacaccacg 69780 cccgagcgca tcgagcgggc catcggcccc cggaccaggg cgatcatgat cgcgcacgcc 69840 ctcggcaacc ccttcgaggc cgaagaggtg gcccgactcg ccgacgagcg cggcctgttc 69900 ctcgtcgagg acaactgcga cgcggtgggc tcccgctacc ggggcagact cacgggctcc 69960 ttcggcgacc tgtcgaccgt cagcttctac cccgcgcacc acatcgcgat gggcgaggga 70020 ggctgcgtgc tcaccgacaa cctggccctc gcgcggatcg tggagtcact gcgcgactgg 70080 gggcgcgact gctggtgcga acccggcgag gacaaccgtt gcctcaagcg gttcgaccag 70140 aaaatggggg acctgccgcc cggctacgac cacaagtaca tcttctcgca tgtcggttac 70200 aacctgaagt ccaccgatct gcaggcggca ctcgggctgt cccagctgac gcggatcgag 70260 gagttcaccg acgcccggcg cgccaactgg cgccggatgc gggagacgtt ggacgggttg 70320 cccggcctgc tgctgccgga ggcgacaccg ggcagcgacc cgagctggtt cgggttcctc 70380 atcaccgtgg acccggacgc cacgtacagc cgggcggccc tggtcgacca cctggagtca 70440 cgccggatca gcacccgccg cctgttcggc ggcaatctcg tccgccaccc cgcctacacc 70500 ggccgtcagt accgggtgtc gggcgccctg gagaacagcg acctgatcac cgatcagacc 70560 ttctggatcg gggtcttccc cggcatcacc acggagatgg tcgactacgt caccgacacc 70620 gtccgggagt tcgtgctcaa gcactcctga cacgtccgcg gaacgtcggg gtggggaggg 70680 ccctgtcggc cctccccacc ccgacgttca cggccgcggg tgcgcctgca actccgaggc 70740 gaggtcgggg tggaccagcg ccgtgagcag ggtgccctcc ggcgtgtgct cggcactgag 70800 cacctcgccc tcgtcgtgcg cccgcgccac caggcccccc tcgtcgtagg ggatcacgac 70860 ctcgacctcc acggcggggt gcggcagcag gcggtcgatc agctcctgca actcgtcgat 70920 gccctgcccc gacctggcgg agacaacgat cgcgtccggc tcctgctcca gcaggcgggc 70980 gagtacgtcc gggtccgcga cgtcggcctt gttgacgacc acgatctcgg tggactcggc 71040 ggcgcccacg tcccgcagca cctcgcgtac ggaggccagc tgcgcgccgg ggtccgggtg 71100 cgacccgtcg accacgtgca gcaccaggtg cgcgtccgcg acctcttcga tcgtggagcg 71160 gaacgcctcc accaggtgat gcgggagatg ccgtacgaag cccacggtgt cggcgatggt 71220 gtacgtgcgc ccgctgggcg tggtcgcccg ccgcacggtc gtgtccaggg tggcgaacaa 71280 ggcgttctcc accaggacac cggcgccggt gaggcggttg agcagtgagg acttcccggc 71340 gttggtgtag ccggcgagag cgaccgacag caccttgttg cgccgtcgtt cctcccgctt 71400 cacgtcccgg cccgtcttta actgctccag ttcccggcgc agtcgggcca tcttgtcgtt 71460 gatccgccgc cggtccgtct cgatcttcgt ctcaccgggg ccgcgcgtgg ccatgccgcc 71520 gccaccgccg ccgcccatct gccgggacag cgactggccc cagccgcgca gccgcggcag 71580 catgtactgc atctgcgcca gcgccacttg cgccttgccc tcccgggact gggcgtgctg 71640 cgcgaagatg tccaggatca gcgccgtgcg gtccacgacc ttgacgccca cgacctcctc 71700 gaggtgcatc agctggctgg ggctcagctc tccgtcgcac accacggtgt cggcgccggt 71760 ctcctcgacg atgtcgcgca gctgcgacgc cttgcccgag ccgatgtacg tcgccgggtc 71820 gggcttctgc cggcgctgca cgaccccgtc cagcacgagg gcgcccgcgg tctcggccag 71880 cgccgccagc tcggcgagcg agctctcggc ctcggcggcc gttcccgagg tccagatgcc 71940 gacgagcacc acccgctcca gtcgcagctt gcggtactcg acctcggaga cgtcggtcaa 72000 ttcggtggac agccccgcga cgcggcggag ggaggcccgg tcctcgcggt cgaactgctc 72060 gccgtcccac ccttcggcgt cggccgcggc caatgtgtcg ttcatcagtg cgtcggctcg 72120 ctgggaggtg ccggcggagt cttcgggatg tgtcaaagta cgtcccttct gggggctcag 72180 gagcgttccg gggtggtgtg cggtcggctc ggcgggatgc gcacgggtcg ggaaatgggc 72240 cgacgtgccc gcaccgcgcc ccacaggccg gtgccgctga agtcgctgcc ggaactcacg 72300 tgttgaccac cctagccatc ccgccgaggt gcgcaaacaa gtatcggtga tcacgtctcc 72360 agctgacaga gtctgcaccg ggtactgcgc acgcgggcgt ggagcgggca agtgtgatgt 72420 catgcgagta ctcattatcg gaggttcaca gttcgtgggc cgggcctacg ccgccgaggc 72480 gctggccgcc gggcacgagg tcaccacgtt caaccggggc gtcagcggca cggacctgcc 72540 cggcgtcgag gcggtcaggg gtgatcgcga ggcggccggc gacctggagc ggctggtgtc 72600 cggaaggcgc tgggacgcgg tcgtggacac ctgcggctac gtgccccgta cggtgggcgc 72660 ctcggccgcg gcgctgtccg ggcacgcgga cgcctacctc tacgtctcca gcatcgcctg 72720 cctgcccgac tggacgcagg cggtccgccc ggtcgacgac gactcaccgg cctacgactg 72780 cccgccggac gcaggcccgg accacgccga cggcgactac ggcaccctga aggccggctg 72840 cgagcgcgcc gtggaccagc acttcgtggg ccgcaccctg cacctgcggg ccggcgtcat 72900 cctcgggccg cacgacaaca tgcgcatgct cgacgcctgg ctgtggcgca tgcgcgccgc 72960 cgagggggag caccgccggg ttctggcccc gggcggcccc gaggtcggca tgcgcctgat 73020 cgacgtgcgc gatgtcgccg ccttcggcct cgactgcctc gccgagggcc gcaccggcgc 73080 gtacatcgtc aacccgccgg agaagaacac cacgttcggg aatctgctca cggagtgcgt 73140 caaggccacc gggtccgccg ccgagccggt atgggtcgac gaccggtttt tcgccgacca 73200 cggcgtgagc ccgtggacgg acctgccgct gtgggttccc gacaccgcgc aggacaccct 73260 ggtctgggcg gccggggcgc cgcgcgcacg ggccgcggga ctggcctgcc gcccgatctc 73320 cgagacggtg cgtgacgcct gggaggtcat ccgggaccag cccgtccctg agcttccgct 73380 cgctgccggc tgcggccttt ccctggcccg ggaaagggag ttgctcgccg cctgggacgc 73440 gcgcggcggt gcggccggct gacgcggccc cggggagtgc ggcgccgttt cccgttcgcg 73500 gggagcggcg tcttccgttt ccgacccatg gggcggcgct ttccggctct tcgcgcggag 73560 ctacaccgtg acggtctcgg cgcgggcgac gatctcgtcg accaacgccg cctgacgcag 73620 ggcggcatac gactcggcgg agatgttctc ggcccgggtc accgcgcggc ggaagaccga 73680 caggatgttc acgaagtgcc ggtccacggg cagcactcgc tcttcgcggt ggtcctggcg 73740 ggacagccgc agtacggggt ggtggctgtc cggagtcgtg aagacgtggt tcagggcgag 73800 cgagccggtg ctgccgtgca gttcgtacgc cgagcggtag ccgtgttcca tgccgaaggc 73860 gaggtgggcg gccacccccg tcggcgcggc cagcaggacg ctgccggaga ccaccacgcc 73920 ccggcgccgc tcgcggcgca gcaccgctcc catcaggcgc agctcgggcc cgaggaagtg 73980 gatcgcggcg cgcagcgggt agacgccgtt gtcgaggagt gcgccgccgc cgatgtcggg 74040 gcggtagcgc atgtcgtcgt cggggcgcgg cgggatggtg aaggcggcgg agaaggtgcg 74100 caggtctccg atggccccgg tctccaacag cactttgacg gtggcgtgtt gcgagtggtg 74160 gaggaacatg aagttctcca tcagcaccag tccgcgctcc cgcgccatgg cgaaaagccg 74220 tgccgcgtcg gcgtggttgg cggcggcggg cttctccacc agtacgtgtt tgcccgcccg 74280 cagcgcggcg gcggcccatt tggcgtgcag catgctgggc acggcgatgt agacggcgtc 74340 cacgtcgggg cgttccagca gtgcctcgta gggcgcgacc gcctcgcagc cgaagtgctc 74400 ccccagggcc ttggcccgtt ccggttcacg gctgccgacg caggtcagca cggtgccggg 74460 ggtggagagc agggcgggca gggtgcggcg gcctgcgatg tcgccgcaac ctatcgctcc 74520 gaagcgcagc accggggacg cttcgggcca cggcgggccg ggtgcggcgg acggttcggc 74580 tggagtaccc agggcggtca tggatggttc cgtcaatcgg tccggatggt cacggcacag 74640 cgtggtgaac ggccggcgcg cacccacgag tcgcttccga caatgggcgg ccctgaagct 74700 acccggccgt ggggcgcgac gacaaggccg atctgacaca gtgccgcgcc aaggggccgc 74760 cgccgccctg cggacccgtt gacctgacac ttcgccaccc aatctgtgga cgggacggtc 74820 gcggtccggg ttaggtgagc gcggcgcccg cggccacgcg acgcctgtcc gaagcggccc 74880 tcggggcacg ccatttgaga gaggagacgc gggtggcaga cgcgatcacg accgagctgg 74940 cggaccgcga actgggccgc agactgcacc ggatacgggg cgcccactgg tacttcggca 75000 accacggcga tccgtatgcg ctcatcctgc gcggccaggc ggacgacccg tcggcgtacg 75060 aggagcgggt acgggacggc ggaccgctgt tccgcagcca catcgggacc tgggtgaccg 75120 cggacccgga ggtgggcgcg gccgtgctgg gcgatccccg gttcggcgcg ctggatcgcg 75180 ccgggcggcg ccccgaggag tacctgcagc cgtcgcccgc ctcgtgcctc gggctggacc 75240 gtgccgcgta cctgcgtctg cggcgggtgg ccgaaccggt gttgggggcg ggcgccgccg 75300 acgagtggcg ccggctcgcc gaggacctcg gtcgtcggct gctcgacggc cgtggttccg 75360 gcttcgacct gacggcggac ttcgcccgcc gactgcccgc gctggtcctg gccgcgtggc 75420 tcggggtgcc ggacgaacgg cgggaggagt gggaggagtt gctgcgggag gcggggccac 75480 tgctcgacag cctgctgtgt ccgcagacgc tggcggccac ccgcgcggcg gactcggccg 75540 ccgaggggct gcgcacgctg ctgggcaagg tggccgtcgc gcgctccgac ggggccggcg 75600 acggcgcgct gggccgcatg gtcgccgccg gggccgcccc ggacgacgcg gtggccgccg 75660 ccatgtgcct ggtgctctcg gccgccgaga cgaccacgac cctggtgtgc gatgcggtcc 75720 gcctgctgct cgaccgcccg cgatggtggc gggcgctgtg cgactccccc gctctggcgc 75780 cggccgcagt ccggcacacc ctgcggtacg tgcccccggt gcggctggag agccgggtgg 75840 cccacgagga cgtggcgccg acggggcacc cattgcccgc cgggagccat gtggtggtgc 75900 tcgtgagcgc cgcgcggcgc ggggccgccc cggacgccgg accggcggac ctgacgaacg 75960 tgcccacggc ggccggggcg ggcctgccgg acgacctgta cttcgcactt tccggggagt 76020 tcgtcgggcg aaccgccgag accgcgttgg gcgtgctggc cgaggtagcc ccccggctgc 76080 ggcgggaggg cgacatcgtc cggcggcgcc gctcccccgt cctcggcagg tatgcgcggt 76140 tccccgtcgc gtactcctga caggcccccg gccggtatcc ccctcagaac ccctcgaagt 76200 ccgatgaaag gagtcccgtg cgcgtcctcg tgacttccat tccgcaccac acgcactact 76260 accacctggt gcctctgatc tgggcgctgc gtgcctcggg gcacgaggtg gtggcggccg 76320 gccagccgtc gctgatcgac gccatcacct ccagcggcat cccggggttc ccgctcgccg 76380 aggaggagtc gctggcccag atcttcgagg aggtcgaggg cgatcttcag ccgtatcagc 76440 acgggatcga cgagttcgac ttcctcggta ccctgcagga cgccctggac tgggagaagt 76500 tgctcgccca gcaggtgatc ctctccggtc tgtggctcga accgctcaac ggcgccacga 76560 ccctcgacag catcgtcgac ttcgccaggt cgtggaagcc cgacctggtg ctctgggagc 76620 cgttcaccta tgcggggccg gtggcggccc gtgcgtgcgg ggcggcgcat gctcgcgtcc 76680 tgtggggtcc ggacacgatc gggctgatgc ggacgaagtt cctccaggcc caggcgcagc 76740 agcccgagga gcaccgggac gacccgatcg cggagtggct gacctgggcg ctggagcgct 76800 acgggtgcga cttccgggag gaggacgtgc tcggccagtg gagcgtggat cccatggcgg 76860 agggcgtcag cctcggcctg gacctgccga ccgtcccgat gcgctacacc ccgtacaacg 76920 gctcggcggt gattcccgac tggctgaccg aggagccgaa gcgcccgcgc gtctgcctga 76980 ccctgggggt gtcctcgcgg gagtacggcg aggacgaggt gccggtgcag aagttcatcg 77040 aagcgctggc cgacctggac atcgagttgg tggcgaccct ggacgacgcc cagcgggacc 77100 tgctgccgcg gatcccggac aacacccgga tcgtcgactt cgtccccatg gacgcgttgc 77160 tgccgacgtg ctcggcgatc atcaaccaca gcggctcggg cacgtgcaac accgcggcgc 77220 tgcacggggt gccgcagatc atcctcggca acatcctgga cgccgccgtg cggcagcaca 77280 tgttcgcgca gtcgtccgcc gccctcacct tcgccccgga ggaggtgacc ggcgagtcgc 77340 tgaggagcgc gctggtgcga ctgctcgggg aaccgaagtt ccgcgacggt gcgcagcggt 77400 tgaaggagcg gatgcgggcc atgcccagtc cggccgggat cgtcccgacc ctggagagcc 77460 tcacggcccg gcaccgccgt gcctgagggg ccgtcaagtg tgtgatgcag caaggctatc 77520 gcgtgacacg actcctgcgc gtaatcgatc tcgtcgactc agccgtggac cggttcgcct 77580 gtccgcgccg gacactggag tgttcatgcg ggcccttttc acgaccgcgc cgctcgccgg 77640 tcacctgctt ccgctcgtgc cgacggcatg ggccctgcgg gcggccggtc acgacgtcct 77700 ggtgacgacc cgggagaact tcgtcccggt cgcgctgcgg tcggggctgc cgtcctcctc 77760 gtgcgggccc gccgtcgatt tcacgggcac ggtcgccgac ggaccgctcg cgccgtctcg 77820 ggacgaggcg gggcagcggg gcgtcctggg cggggcgttg gcgcgcgtcg cccggggcag 77880 cctggccggg gtgcggcggc tggcggacgt ctggcggccg gacttgatcg tcagcgaacg 77940 ggccgagttc gccggaccgc tggtcgcggc ggccctcggc atcccgtggg tccgctacca 78000 ctggtcggtc tcctgtctgg aggagtaccg gcgcgcggcc gaggaggagt tcgcgccgga 78060 gctgaccgcg ctcggcctcg accggttccc ggatcccgcg cgcgtgctcg atccgtggcc 78120 ggtgtccctg cgccggccgg acgcggtcgc ccacgacggc atccggcacg taccggccca 78180 cggggacgcc cccgtgccgg agtgggcgtt cacgcgcggc cgcaggcccc ggatctgcgt 78240 gacgctcggc accatgctgc cccggtacgg cgcgttcggg gtgcgcgact tcctggcgga 78300 gctggtggag gagacgcgcg gatcggactg cgagctgctg atcgcggtcg acgacgacat 78360 cgtcgcgcgg tggccgccgc tgcccgccgc ggtgcggcac gccggccggc tgccgttggc 78420 cgaggtgctg cccgcctgcg acgtggtggt gcaccacggc ggtcagggca cgtccctgac 78480 cgccctggcc gcgggccggc cacaggtcgt catgccgcgg ctcgacgacc agttcgacaa 78540 cgcgcaggca ctggcggcgg cggatgcggc cctgctcgtg ccaccgtccc tggccactcc 78600 cgcggccgtg gccgcggggt gcgccgaact gctggagaac gccctgtatg ccaaggcggc 78660 agccgggctc gccgagacga tggcgctgct gccgtcgccg tcggcggcgg tcggacccct 78720 ggagcacctg gggcctgcac cgggcatgct gcggagccac gcgaacgagg atgcggtgtg 78780 acgtgatttc cgaagtactc aaccgttcga acgatccgcg cgggccgttg atcacggtgg 78840 tcggcgcgtc cggcttcatc ggatccgccc tggtcgccga gttggcgcgc acgccggtgc 78900 ggctgcgggc ggtgtcccga cgcgaggccc ccgtccccgc ggggacgccg gccgccgtcg 78960 aggtccgccg ggcggacctc gcccggccgg gcgaggtccg ggacgccgtc gagggggcgg 79020 acgcggtcgt gcacctcgcc gcccacatcg gcggcgcgca gtcgtggcgc gcggccgacg 79080 agcggtcggc gcgggtgaac gtcggcctgc tgcacgacct ggtcgacgcg ttccggggcc 79140 gctcgggcac cctcccggcc gtggtcttcg ccagtaccct gcaggccggc gccgacgtcg 79200 cccggcaggg cgcgtacgcc cggcagaagt cggccgccga agaggtcctg ctgcgggccg 79260 cgtccgaggg ggtggtccgg ggcgtcgtgc tgcggctgcc gaccgtgtac ggccgcagcc 79320 cgctgaccgg gtggaccggt cgcggggtgg tcgcgtcggt ggcgcggcgg gccgtcgagg 79380 acgggccggt cacgatgtgg cacgacggca cggtcgggcg cgatctgctc cacgtggagg 79440 acgcggcccg cgccttcgtg gcggcgctcg accacgcggc gcggctcgac ggcggcacgt 79500 ggtccgtcgg caccggccgg ctggagccct tgggagaggt gttctcgacc atcgccgggc 79560 tggtgtccga gcggacgggg aggccccccg tcccggtggt ctccacggag ccgcccgacc 79620 atgccgaggc gggcgacttc gacagcccgg tctccgaccc ctccgcgttt cgcgcggtga 79680 ccggatggtc tccccgcgtt ccgttgcagg cggggctcag cgccgtggtg gagacgatgg 79740 tggccgcgga atcgaggggt gggatccgag gttgagcacg gaccggaatc aggccgcgca 79800 cacgcggctc ggccgcagcg cgacgctggt gagccggctc tggctgggca ccgtgaactt 79860 cagcggccgg gtcgaggacg cggacgcgat gcacctgatg gagacggcgg tcgaccgcgg 79920 catcaactgc atcgacacgg cggacatcta cggttggcgg gtccacaagg ggcacaccga 79980 ggagttggtg ggccgttggc tggccaagag cgccgcgcgg cgggaggacg tcctgctggc 80040 caccaaggtc ggcggggaca tgagcgaacg gctcaacgac ggcggcctgt cggcccggca 80100 catcatcacg gcctgcgagc agtcgctgcg gcgtctgagg gtggaccaca tcgacctgta 80160 ccagatgcac cgcatcgacc acgccgctcc ctgggacgag atctggcagg cgatggaccg 80220 tctggtggcg agcggcaagg tgacctacgt ggggtcgtcg aacttcgcgg gctggaacgt 80280 cgccgccgca caggacgccg cgcggcggcg gcggtccctc gggctggtgt ccgagcagtg 80340 cctgtacaac ctggcggtac ggcacgccga gttggagttg ttgccggcgg cgcaggcgta 80400 cgggctggga gtgttcgcct ggtcgccgct gcacggcggg ctgctcagcg gggtgttgcg 80460 caagctggcg gcgggcactg cggtgaagtc ggcgcagggg cgggcccaac tgctgttgcc 80520 cgagctgcac gccacgatcg aggcgtacga ggggttctgc gaccggatcg gggcggaccc 80580 ggccgaggtc ggcctggcct gggtgctgtc ccggccgggg atcagcggtg cggtgatcgg 80640 gccgcgcacg gtggagcagc tggactcggc gctgcgggcc ctggacctgg tcctcgggga 80700 ggccgaactg gccgaactgg acgccatctt cccggccctg ggcaacggcg gccgggcgcc 80760 ggatgcgtgg atcagctgaa gggcggtgca tcggccgacg tcacgccggc cgatgccgcc 80820 ggtcatacga cgtcgagcgc gggcagcggg aagatcagtc ggccgccgcc gtcgaggaag 80880 tcccgttccc gctcgacgaa tccgtcccgg tagatccagg gcaggaccag caattggtcc 80940 ggcttctgtg ccttcgcgtc ctgttcggac acgatgggga tggccgttcc cggggtgaag 81000 cggcccgcct tctcctcgct cacctcaccg atgcagggca ggtcccgctc ggtgatcccg 81060 cagtactgca ggatgacgtt gcccttggtg gaggcgccgt accccagggt cagcctgccc 81120 tcttcgcggg agcggtcgag gaagtcgcgc agggcgcccc gctggttcac gacccggcgg 81180 gcgaagccct cgaacggcgc catgccgtcc agtcccgccg cggcctcccg ggcacggatg 81240 cgggccaggc ccgcatcgtc cttccggtgc tgggagccgc tcctggccag cgtgacgcac 81300 aggctgccgc cgtacacctc ggtgagctcg gccctgatga cagtcaggcc gacccgctct 81360 gccatccact cgatctgccg gagggcgtag tactccaggt gctcgtggca gacgatgtcg 81420 tacgcgtcgg cttcgagcat ggcgggcagg tagctctgct ccatcatcca gatgccgtcc 81480 tcggtgagga cgtcgcggac gtcgctcatg aagcgcagcg ggtccggcag gtcgtagaac 81540 atggctatcg aggtgacgac cttcgcccgc cgcgcgccga accggctctc gaaggtctcg 81600 cgggtgaagt agtcgacgat caactcggcg ttccgcgggt acagttcgcg gaacttcccg 81660 ccggtcgggt cgatgccgac cagttggggg ccgtcggcag ggtagccgct cagcagtgtc 81720 gcgtcgttgc tgccgatgtc gacgaccagg tcgtccgggc cgaggtccac cagctcgcgg 81780 atggcggcga ccttgccgtg gaggtggtcg accatgaacg gccggatgcc cgagcggtag 81840 ccgtagccct ctccgtacat gaggtccgga tcgggggtgt ggcgcagttg cacgaggccg 81900 catccggccg gggaacagac gacgagttcg agcgggaccg acggcacaac ctgttcgcgg 81960 ctcgtcggga acactccggt gagcgcttgt tcgcccaggt cgagtacgga gagcagctcc 82020 ttgttgccgc agacgcggca cgcggtggca atcatggggt cctttcggaa tccgggccgg 82080 ggcgccggcc cggggccagg tcgggggctt cgagacggag ggtgtcgggg gtgggctggg 82140 gggacggcat caggtgcagg cggccgatcg caccggtggg ggcggacgcg tcctggcacg 82200 ggcaggggtc atcggtgaat ccggcgaagc ggtaggccac ttccatcatt cggttgcgtt 82260 cggtggcgcg gaagtccgcg ccgaggtgca ccccggcccg gtgtgcctgg tcggtcagcc 82320 agcgcaggat cgccgtgccg gcgccgaggg acaccacccg gcacgaggtg gccagcagct 82380 tgatccgcca ggcgtcgggg ctgcgccgca gcagcacgac gccgaccgct ccgtaggggc 82440 cgaagcgatc ggtgaccgtg gtgaccagca cctcgtggtc ggggtcgtcg atgagggcgc 82500 gcagatcgtc ctcggagtag tgcactccgg tggcgttcat ctggctggtg cgcagggtga 82560 gttcctcgac ccgggacagc tcgtgggggg tggcgcggct gatccgcatc ctgatgtcca 82620 gcgagcgcag gaagtccgcg tcgggcccgg tgaagtcgga ccgttcggcg tctcgccgga 82680 aggacgcctg gtacatcgag cggcggcgcc gcgagtcgac ggtgacggtg tccgggctga 82740 actccggcag gtcggtcaac ccggtcgcct gtccggcggt gtaggtgcgg acctccggca 82800 actcgtgtgt cacctcggcg cgttcgaagg gctggtcgtc gatgaaggcg agggtgccga 82860 gcgcgaagtt gagccggtcg gcgatctcgc ggaccgactt cgacttcggc ccccagccga 82920 tctgcgggag cacgaagtat tcggcgacgc cgagctgttc cagtttcgcc caggcgtggt 82980 cgtggtcgtt cttgctggcc acggcctgga ggatgccgcg cgcgtccagc tcggcgatgg 83040 tccgcaggac gtccggggtg agccggacct cgtcctcctc caggagtgtg ccctgccaga 83100 gggtgttgtc cagatcccag accaggcatt tgaccagggg ctcggcggcg ttgtcccggt 83160 gcacgtcgtt cctttctctc gatacggcgg atgcgaccgc gactgtctcg atacggcgga 83220 tgcggccgcg actcttcgac aggcggacac cgccgggacc agaaggatta cggcccgttc 83280 atcccgcggc ggacaccgca tgccgggcca ggatcagctc gcagatctcg ttgctgccct 83340 cgatgatttc catgagcttg gcgtcgcggt gcgcccgggc gacgacatgc ccgtcgcggg 83400 ccccggccga cgccagcacc tgcacggccc gctcggcgcc gcgtgcggcg ccggtggccg 83460 cgacgtgctt ggccaggacg gcggcgatca ccatgtcggg gctgccctcg tcccactggg 83520 cgctggcgta ctcgcacgcc ctggcggcgt gctgttcggc gatgaacagt tcggcgaggt 83580 gccgggcgac gagttggtgt tccgaaagcc gcgtgccgaa ctgctcccgt ccgctggtgt 83640 gccgcacggc ggcggccaga cagccgcgca ggatgcccag ggagccccat gccacggaca 83700 tccggccgta gctcagcgcg gtggtgacca gcagggcggg ggtgcggtcg tggccctgca 83760 ggagggcgtc ggccggcagc cggaccccgt ccaggtggat gttcgcatga ccggccgcgc 83820 ggcagccgtg cgcgtcggcg atgcgctcga tccgtacgcc gggggccgag gcgggcacca 83880 cgacggcccc cgcgccctcc tccgtgcgcc cgaagaccac cagcaggtcc gcgtaggcgg 83940 cgttggtcgc ccacaccttg accccgtcga cgacgatctc gtccccgtcg aaggcgatac 84000 gggtccgcaa ggcggacagg tcactgccgg cgccggcttc ggtgaaggcc acggcggcca 84060 gttcgccact ggtcaaccgg gaagtcagcg gggcctgttg gtccgctccg gcgagtcggc 84120 gcagcgtcca ggccgccatg ccctgcgagg tcatgacgct ccgcagggag ctgcacaggg 84180 cgcccacgtg cgcggtgagt tcgccgttgc gccgactgga ccagccgagg ccgccgtggg 84240 ccgcgggcgc ctgcgcgcac agcaggcccc gggagccgag atcgcgcagc agggagaggg 84300 gcagctcgcc cgtacggtcc cactcggccg cccggtcgcc gaccagctcg gtgaacagtt 84360 cctcggcctc ggatgcggcg gcatgcggcg cgtcagccac cggcgggccc ggtcgcctcg 84420 ccggtcggac cgggcgcggc cagccgtccg accagccgga ccatcgcgtc gacggtgcgg 84480 aagttgtcga gcatcaggtc ggcgccgctg atgacgattc cgtgggtctt ctccaggtgc 84540 acgacgagct gcatggcgaa cagcgaggac atgccaccga cggcgaacag gtcctggtcg 84600 cgctcccagg tggtcttggt gttggccgcg aggaaaccga gcagttcctc ggccacctcg 84660 tcgtcggcgg gcgtcgtgcc ggtcgaatcc ggccggccgg aagtcgtggt cattgcatgg 84720 tctcctggta gtcgtagaat ccccggccgc tcttgcggcc gagcaggccc tgccggacct 84780 tgtccagcag cagttcactc gggcggagag ccggatctcc ggtccgttcg tgcatcaccc 84840 gcagcgagtc ggccaggttg tccagcccga tcagatcggc cgtggccagt ggtccggtgc 84900 ggtggccgat gcagtcgcgc atcagcgcgt ccacggtttc cggggtggcc ctgccctcgt 84960 gcaccaccgc gatggcgtcg ttgagcatcc ggtgcaggag gcggctggtc acgaacccgg 85020 cgccgtcgcc gacgacgatg ccccggcggc ccagtccgga cagcagttcc cgggtcgact 85080 ccgcggccgc ctctccgctg cgtggtccca ggaccacctc gaccgtgcgg atcacgtacg 85140 cggggttcat gaagtgcacg ccgaccaggt cctcggggcg ggggacggca tcggccagtt 85200 cgtcgatggg aacgcccgag gtgttgctga tgagcagcgt tccggggcgt gccgcggacg 85260 ccaggtccgc caggacctcc gccttcctct tggggtcctc ggtgacggcc tcgatcacgg 85320 cggtcacggc ggcgatggcg ttcagggcgt cctcgacggt cagttcgccg ggcgggcggt 85380 cgtggggcag cgcgcccatc agccgggccg tccgcagatg gagtgcgacc gtgtcggggg 85440 cggcggcgcg cgcctcgacg gacgtgtcga tcagggtgac cgggtgtccg tgtccgacgg 85500 cgagtgcggc gatggccgtg cccatgacac ccgctccgag cacgacgagc ggagaatttt 85560 cattggaatt gggcacagag cctccagaat cccgggacga cggctgtgcg aaatgctgtc 85620 ccgaatcgct tctgtgctcc atcacttggc cgtgactttg tcacctagga agcggtgcgg 85680 gcctggcgga ggctatgtca tctccggctt gtccaccccg gagttccgta cctaaagtgc 85740 gcccggcgaa cgcgcggcgg aattaccgcc gtttcctgcc aagggcccgt ggtttgaacg 85800 acctcgacgt atgaagggtt tcacatggct catatcgcat tcttcatcct tccggttgcc 85860 gggcatgtga atccgacgct gggagtcgcc gaggagctgg tggcgcgcgg ccaccgggtg 85920 acgtacgcgc tgtccgggga gctcgccgag cgggcccggc tgatcggcgc cgaggtggtc 85980 acctatcccg tggacaagca acggttcctg gaccagatgg tgcctcggca ggacgcggac 86040 gagtacacgg acgagggcga gttcgtacgg gtcctggagt ggctgctgga catgacggcg 86100 cagaccctgg aaccgctgga gcggcacttc gccgagaacc gtcccgatgt cgtcgtcaac 86160 gacccgtcgt cgctgtggac ggggcggctg ctggcggacc ggtgggacat cccggtcatc 86220 cgcagcactc cgacctacgc cgccaacgag cactggtcgc tgcatccgcc cgtcgactcg 86280 gccgagccgc cggacgatcc cgagctgcac aagctgctcg cgcggatcga gcggctgctg 86340 gaggagcagg gcgtcgagca cgacctggcc gccttcaccg gggtcctgca cggcggcccg 86400 gccctgctgt acatgccgcg ctcgttccag tacgcgggcg agaccttcga cgaacagcac 86460 cacttcgtcg gcccctgccc gccccggacc gcgttccacg gcgagtggac gccgacggac 86520 gacgacggcc ggcccttggt gctggtgagc ctgggaaccc tctacaacga ccggccggac 86580 ttcttccgca cctgcctgga ggcgttccgc gacgagccct ggaacgtcct tctggtgctg 86640 ggcggcgggg tgcccgccgc cgacctgggc ccgcttcccg acaacgtccg ggtgcacgac 86700 ttcgtgtcgc tgcgcgatgt gctcccgcac accgccgtgg tggtgaacca cggcgggatg 86760 agcaccgcca tggaggtgtt ctcgcacgag gtgccggtgg tggcgatccc ggtgatgccg 86820 gagcctcggg ccaccgcgcg gcggatcgtc gaactgggtc tcggtgacca gctcctgaac 86880 tcggagctga cggccgagtc cctgcgtgcc accgtgcggc gggtgctgga ggactcccgg 86940 atcccggcga acatgcggaa gatccgtgag cagatcacgg cggccggcgg ggcgaatgcg 87000 gcggccgacg cggtcgaggg actgctgccc caggggagct gaggcgtcct cgcatccgaa 87060 acgcgttcac cttccgaccg gcgggatcgc tccatgctca tcaccgaaac gaccgtgccc 87120 gacgtcttcc gcattgatcc ggagcccatt cccgaccatc ggggccggtt ctacgaagcc 87180 gtgcgccaga ggccgctgga ggctgccgtc ggtcactcga tcgcggtccg gcaggtcaac 87240 ttcaccgtct ccgggcgcaa tgtgctgcgc ggtctccacg ccaccacact gccgccgggc 87300 cagggcaaga tcctcacctg cgtgcggggt tcggtactga ccatggtggt cgacatgagg 87360 gtggggtcgc cgagcttcgg acggtacgag gccgtccggc aggatccgcg gtcgggcacc 87420 gccctctacc tgccggacgg catcggcctg ggctatgtgg cactcgtgga cgacacctgt 87480 atgaactatc tgtgcacaca cgaatacgtc ccgggcatgg tcatcgacgt cgatgcgctg 87540 gaccccgaac tcgacctgcc ctgggacctg gccgacactc cgatccggtc cgccagggac 87600 gccgcggcgc cgtccctgcg ggcggccgtc tccgcgggga tcctgccgac gtacgaggag 87660 tgcctgcggg tccgtgagcc cctacccgcc gctcttgact gaatgcgttc ccaaaaagcc 87720 ttgccggggt cggggtcgac gccgacgccg acgccggcag ggacaaacgc gtaaaagacc 87780 tgcggcgcca tgaaaacagg gcgccaagga aaaggaacgg ttgcgaagtc ggcccgcaac 87840 cgctcatgca attccggaac tgacagccgc cgccccgctg gacgagaacg gccgagttct 87900 tcgcgcagac cgcgcgcgag gacgccgccc ggcattcccc gccgaccgcg cgccactcgt 87960 ccgactcccc ctgcggctgc accagttgcg cggcgggcgc acttcgggcg gcagcagcac 88020 tcgtggagga cggtctccgc cctccacgag tgcaccgggc gactcggccc cgtgcgaacg 88080 acacacgagc tcggccccgt gcgaccggca cgcgtaccgg gccggtcgca cctgccggaa 88140 cgtcacaccg ccgcgacccc acggaagtcg acccgcgcgg agggctgcgc cagccgcagc 88200 gtgtgggcga tggacgccag cgtcacgtgc cggtgccagc cctggaacga ccgtccttcg 88260 aagtcgcgca tgcccacgcc cacactcacc cgttcgaagt cggcgtccac ctgctcggtg 88320 agcatggcca gccgcaacaa cgcgccgcgg tcccaggacg tgaggtcggt cagccacagg 88380 tcggccgggc gccggcggtt gccccgccac acccccatca gcaccagggt ccgcctcggg 88440 accacgcccg gcagcaccac ggcgtgcggg gcgacgagac tgagggagcc ctgccactcc 88500 acggggcgac tcaaccgctt catctgctcc attagttgct gggccgaggt ggtcgcggtg 88560 tggtggtcca ccaggccgcg cccacctgcc gacgccaatt ggaggttccc gcccacacgc 88620 accatgaagg gcagacccac gagactgagc ccacgcacca agcgcggcag aacggcggcg 88680 cgcgcgtcca tcaccacggg tcgcgccgag gtccggctgg cctgggcggc ctcggccacc 88740 aggcgaacga cgttctcctc ctcaccgagc gcaccgggcg cgccgagttg ccgggaaccg 88800 ccgtcgccgc cccggccgcc gcccagcgtc aggtgccagc tgaccggggc cgccgtcgcg 88860 cccgaggcca gccacagtcc gtggctctgc tggcagctca ccacccgccc cagatcgggc 88920 acgaaccgcc ggctcacccc gaccgagcgc acccccgcct tggagaccac catcggccag 88980 atcacccagg cctcggggtt cagcctgtcg tccacgtagc gggccagcgc ggcccgcacc 89040 gcgccccagt cccaggtcga cccggcgacg aaatggtgca ggctctgctc cgccgcgcct 89100 tctccgacga aggcggcgag gttccgggcg gtcttgcgcc cctgggcggt gagcagcccg 89160 cgtatgtact gctcacccct tctgcgctgg tccgcccggc ggagcgagcc gagtaactcc 89220 gcacatccct cggagacgag cgagtcgaag tcgtggcccg cggcggggcc cgtcaggggc 89280 gccgtaccgg cgggttcaag cgtacgaaat ttcat 89315 <210> 2 <211> 2337 <212> ADN <213> Streptomyces spiramyceticus WSJ-1£© <400> 1 ggatcatcac tgacgaatcg aggtcgagga accgagcgtc cgaggaacag aggcgcttat 60 cggttggccg cgagattcct gtcgatcctc tcgtgcagcg cgattccgag ggaaacggaa 120 acgttgagag actcggtctg gctcatcatg gggatggaaa ccgaggcgga agacgcctcc 180 tcgaacaggt cggaaggccc acccttttcg ctgccgaaca gcaaggccag ccgatccgga 240 ttgtccccga gttccttcac ggaaatgtcg ccatccgcct tgagcgtcat cagctgcata 300 ccgctgtccc gaatgaaggc gatggcctcc tcgcgaccgg agagaacgac gggaagggag 360 aagacgtaac ctcggctggc cctttggaga cgccggtccg cgatgctggt gatgtcactg 420 tcgaccagga tgatccccga cgctccgagc gcgagcgacg tgcgtactat cgcgccgatg 480 ttcccgacga tcttcacccc gtcgagaacg acgacgtccc cacgccggct cgcgatatcg 540 ccgaacctgg ccgggcgagg gacgcgggcg atgccgaatg tcttggcctt ccgctccccc 600 ttgaacaact ggttgacgat cgaggagtcg atgaggcgga ccggtatgtt ctgccgcccg 660 cacagatcca gcaactcaga tggaaaagga ctgctgtcgc tgccgtagac ctcgatgaac 720 tccaccccgg ccgcgatgct gtgcatgagg ggctcgacgt cctcgatcaa cgttgtcttt 780 atgttggatc gcgacggctt ggtgacatcg atgatccgct gcaccgcggg atcggacgga 840 tttgcgatgg tgtccaactc agtcatggtc gtcctaccgg ctgctgtgtt cagtgacgcg 900 attcctgggg tgtgacaccc tacgcgacga tggcggatgg ctgccctgac cggcaatcac 960 caacgcaagg ggaagtcgtc gctctctggc aaagctcccc gctcttcccc gtccgggacc 1020 cgcgcggtcg atccccgcat atgaagtatt cgccttgatc cccgggggga ccgtcacaga 1080 tccactagtt ctagaaactc cacgggcgct gacgcacacc ggtgcggggc gcgcccgagg 1140 gcgcgccccg caccggtcgt cccgcgtcgg ctacggagtg ccggacgggg cgggttcgga 1200 cctgggtgtc gagccggcgt ccggggaccg ccgcggccgt cccagggttc gcatgaccgg 1260 cttctccacg aagaagtgca ggaacgccga ctgccccagc gccagcgtga aggcgagcag 1320 ggtcagcccg acggcggccg gtgtgtccca ctgccggtaa tagccctgct tcccgccggc 1380 gaagcggtgc cgtactgga tgatcaggta gtgcacgagg tagaaggcga aggtgagttc 1440 ccccagcagc accatcgtcc tggtccccag ccaggagcgg acgccgcgca catcaccgac 1500 ggccaccgag gcgagcagca gcgcgatcac cgggacggtc aacgcgccgg ggtcgtagtg 1560 gttcggcacc gcgaacgtca ccgcgaacac cgctgagaac agcgcgacgc aggccagggg 1620 acgcgggccc ctccagcgtc cccggatcac gatctgggcc atgagcatcc cgagcacgaa 1680 ctccagcagc cgcaccggcg ggaacatgta gatgaaccac caccgcagct gcggcatgtc 1740 cgggtcccac ggcaggggcg ggctggccgg cagcagcagt gcgaccaggg ggatggagac 1800 ggcggccacg gacaccgcgg cggcccaccg ccagagccgg tccgtacgga ccttggtgaa 1860 gaaggcgaag aggaacggga acatggcgta gaagaacagc tcgcaggaga gcgaccacgc 1920 caccgggttc atgctgccgt actcgtggtg gtcggggaac catgcctgga tcagcagcag 1980 gttcgtgagc agtccgtccc acaccgatcg gcccatgttg ggctcgttga gggccagcac 2040 gatcagcagc gtcaccagca gcacgggcag gtgcagcgag tacgcgcgga ccgtgcgccg 2100 ccgccagaag ttcaccttgg acttgtcggg cagacccgcc caggtgagga cgaaaccgct 2160 gagcatgaag aagaacgaga ccgtcagcgg gcccagccgg ttcagcggga actgcagcgc 2220 ggaattgatc tcggtgttct tgaagaacgg ctgtgtcgat atatgggagg tgaataccag 2280 tagagcggag atgaaacgca tcccgccgag cgcgggaaga tgtttcggca ggggcat 2337 <210> 3 <211> 214 <212> Pro <213> Streptomyces spiramyceticus WSJ-1£© <400> 1 Met Glu Ser Arg Gly Gly Asp Glu Ala Asp Tyr Ala Ala Leu His 5 10 15 Pro Glu Glu Glu Ala Val Val Ala Gln Ala Val Asp Lys Arg Arg 20 25 30 Arg Glu Phe Thr Ala Val Arg Ala Cys Ala Arg Arg Ala Met Glu 35 40 45 Lys Leu Gly Phe Pro Pro Gln Pro Ile Leu Pro Ser Glu Arg Gly 50 55 60 Ala Pro Arg Trp Pro Glu Gly Leu Leu Gly Ser Met Thr His Cys 65 70 75 Asp Gly Tyr Arg Ala Ala Ala Leu Val Arg Ala Thr Asp Leu Ala 80 85 90 Ser Leu Gly Ile Asp Ala Glu Pro His Gly Ser Leu Pro Asp Gly 95 100 105 Ala Leu His Ser Val Ala Leu Pro Ala Glu Arg Glu Arg Leu Ala 110 115 120 Leu Leu Ala Ala Gly Gln Pro Gly Val His Trp Asp Arg Leu Leu 125 130 135 Phe Ser Ala Lys Glu Ser Val Tyr Lys Ala Trp Phe Pro Leu Thr 140 145 150 Gly Lys Trp Leu Gly Phe Glu Glu Ala Tyr Ile Asp Leu His Gln 155 160 165 Asp Ser Gly Thr Ala Gln His Gly Arg Phe Arg Ala Glu Leu Leu 170 175 180 Val Pro Gly Pro Leu Val Gly Gly Arg Arg Ile Lys His Phe Glu 185 190 195 Gly Arg Trp Ile Val Arg Glu Gly Leu Val Thr Thr Ala Leu Thr 200 205 210 Val Pro His Pro <210> 4 <211> 200 <212> Pro <213> Streptomyces spiramyceticus WSJ-1£© <400> 1 Met Ser Ser His Arg Ala Pro Glu Thr Ala His Arg Ser Arg Arg 5 10 15 Ala His Arg Ala Ile Leu Gly Ala Thr Leu Glu Leu Val His Glu 20 25 30 Val Gly Tyr Pro Arg Val Thr Ile Glu Gly Val Ala Ala Arg Ala 35 40 45 Gly Val Gly Lys Gln Thr Ile Tyr Arg Arg Trp Pro Ser Lys Ala 50 55 60 Ala Ile Leu Arg Asp Ala Val Val Ser Leu Thr Glu Asp Ile Ala 65 70 75 Arg Ala Gly Gly Ala Val Arg Asp Thr Gly Asp Leu Glu Ala Asp 80 85 90 Leu Lys Ala Val Leu Arg Ser Ala Val Asp Thr Met Thr Asp Pro 95 100 105 Gly Tyr Asp Val Pro Ala Arg Ala Leu Val Ala Ala Gly Ile Ala 110 115 120 Asp Pro Ala Leu Gly Lys Glu Leu Thr Ala Arg Leu Val Glu Pro 125 130 135 Pro Leu Arg Leu Cys Leu Glu Arg Leu Gly Ser Ala Arg Gly Ala 140 145 150 Gly Gln Ile Ala Gln Asp Val Asp Pro Arg Ile Ala Val Leu Met 155 160 165 Leu Ala Gly Pro Val Ala Gln His Trp Leu Met Gly Asp Gly Pro 170 175 180 Leu Thr His Glu Tyr Thr Asp Ala Leu Val Asp Leu Ala Leu Arg 185 190 195 Gly Leu Ala Pro Arg 200 <210> 5 <211> 282 <212> Pro <213> Streptomyces spiramyceticus WSJ-1£© <400> 1 Met Lys Ser Lys Ser Pro Arg Pro Pro Arg Ser Ala Ser Ala Pro 5 10 15 Ala Ala Ser Arg Cys Val Ala Arg Arg Glu Trp Gly Gln Asn Phe 20 25 30 Phe Arg Ala Ala Ala Ala Ala Cys Arg Phe Ser Ala Gln Leu Asp 35 40 45 Ser Ser Asp Ala Ile Ala Pro Gly Ser Pro Asn Asp Leu Leu Thr 50 55 60 Val Glu Ile Gly Ala Gly Ser Gly Arg Val Thr Lys Ala Leu Ala 65 70 75 Ser Thr Gly Ser Pro Leu Leu Ala Val Glu Ile Asp Thr Gln Trp 80 85 90 Ala Arg Arg Leu Ala Ala Glu Ser Leu Pro Asp Val Thr Val Val 95 100 105 Asn Glu Asp Phe Leu Thr Leu Gln Leu Pro Gly Gln Pro Val Arg 110 115 120 Leu Ile Gly Asn Leu Pro Phe Val Ser Gly Thr Lys Ile Leu Arg 125 130 135 Arg Cys Leu Glu Leu Gly Pro Asp Arg Met Arg Gln Gly Val Phe 140 145 150 Leu Leu Gln Arg Glu Tyr Val Gly Lys Arg Thr Gly Ala Trp Gly 155 160 165 Gly Asn Leu Phe Asn Ala Gln Trp Glu Pro Trp Tyr Ala Phe Glu 170 175 180 Lys Gly Leu Ala Phe Ser Arg Gln Glu Phe Asn Pro Val Pro Arg 185 190 195 Ala Asp Thr Gln Thr Leu Met Val Thr Pro His Arg Lys Pro Pro 200 205 210 Val Pro Trp Arg Glu Arg Thr Ala Tyr Gln Arg Phe Thr Gln Gln 215 220 225 Val Phe Asp Thr Gly Gln Met Thr Ile Gly Glu Ala Ala Arg Lys 230 235 240 Val Leu Arg Arg Gly His Ala Gln Phe Val Arg Gly Ala Gly Val 245 250 255 Arg Pro Ala Asp Arg Val Lys Asp Leu Thr Val Pro Glu Trp Thr 260 265 270 Ala Leu Phe Arg Ala His Gln Arg Thr Ala Asp Cys 275 280 <210> 6 <211> 408 <212> Pro <213> Streptomyces spiramyceticus WSJ-1£© <400> 1 Met Leu His Arg Val Asp Leu Ser Ser Leu Thr Gly Leu Arg Trp 5 10 15 Tyr Ala Ala Leu Thr Val Phe Ala Cys His Ile Ala Gln Gln Gly 20 25 30 Phe Phe Ala Asp Gln Gln Val Gly Ser Ala Leu Leu His Ile Thr 35 40 45 Thr Leu Gly Ser Met Ala Val Ser Val Phe Phe Ile Leu Ser Gly 50 55 60 Phe Val Leu Ala Trp Ser Ala Arg Asp Glu Asp Ser Thr Pro Thr 65 70 75 Phe Trp Arg Arg Arg Ile Ala Lys Ile Tyr Pro Leu His Ile Val 80 85 90 Thr Phe Gly Ile Ala Ala Leu Ile Ile Phe Ser Leu Ser Glu Pro 95 100 105 Val Leu Pro Gly Gly Ser Val Trp Asp Gly Leu Val Pro Asn Ile 110 115 120 Leu Leu Val Gln Ser Trp Leu Pro Asp Ala Ser Leu Ala Ala Ser 125 130 135 Phe Asn Thr Pro Ser Trp Ser Leu Ser Cys Glu Leu Ala Phe Tyr 140 145 150 Leu Ser Phe Pro Leu Trp Tyr Arg Leu Val Arg Lys Ile Pro Val 155 160 165 Gly Arg Leu Trp Trp Cys Ala Ala Gly Ile Ala Thr Ala Val Met 170 175 180 Cys Val Pro Phe Val Thr Gly Leu Leu Pro Ala Ser Glu Glu Ala 185 190 195 Ala Pro Gly Met Pro Leu Asn Glu Val Trp Phe Ala Tyr Trp Leu 200 205 210 Pro Pro Val Arg Met Leu Glu Phe Val Leu Gly Ile Val Met Ala 215 220 225 Leu Ile Leu Arg Ala Gly Val Trp Arg Gly Pro Arg Ala Gly Thr 230 235 240 Cys Thr Leu Leu Leu Ala Ala Ser Tyr Gly Leu Thr Gln Val Val 245 250 255 Pro Pro Met Phe Thr Leu Ala Ala Cys Ser Ile Val Pro Ala Ala 260 265 270 Leu Leu Ile Thr Ala Leu Ala Asp Ala Asp Val His Gly Arg Arg 275 280 285 Thr Gly Leu Arg Ser Ala Met Leu Val Arg Leu Gly Gln Trp Ser 290 295 300 Phe Ala Phe Tyr Leu Val His Phe Met Val Ile Arg Tyr Gly His 305 310 315 Arg Leu Met Gly Gly Glu Ser Gly Tyr Glu Arg Gln Trp Ser Thr 320 325 330 Pro Ala Ala Ile Ala Leu Ser Leu Ala Met Leu Met Val Ala Ile 335 340 345 Leu Val Gly Gly Leu Leu His Thr Val Val Glu Gln Pro Cys Met 350 355 360 Arg Leu Phe Gly Ser Arg Thr Pro Ser Ala Val Pro Lys Pro Gly 365 370 375 Thr Ala Pro Ala Pro Arg Ser Ser Pro Gly Pro Asp Val Thr Gly 380 385 390 Val Pro Val Val Thr His Thr Pro Asp Val Thr Asn Glu Leu Ser 395 400 405 Pro Lys Gly <210> 7 <211> 221 <212> Pro <213> Streptomyces spiramyceticus WSJ-1£© <400> 1 Met Ala Asp Gln Thr Ala Leu Ser Pro Ala Leu Leu Glu Tyr Ala 5 10 15 Arg Ser Val Ala Leu Arg Asp Asp Gly Leu Leu Arg Glu Leu His 20 25 30 Gly Val Thr Ala Gly Leu Pro Gly Gly Arg Ala Met Gln Ile Met 35 40 45 Pro Glu Glu Ala Gln Phe Leu Ala Leu Leu Ile Arg Leu Val Gly 50 55 60 Ala Arg Arg Val Leu Glu Ile Gly Thr Phe Thr Gly Tyr Ser Thr 65 70 75 Leu Cys Met Ala Arg Ala Leu Pro Ala Asp Gly Arg Ile Val Thr 80 85 90 Cys Asp Ile Ser Asp Lys Trp Pro Gly Val Gly Ala Pro Phe Trp 95 100 105 Arg Arg Ala Gly Val Asp Ser Leu Ile Asp Leu Arg Val Gly Asp 110 115 120 Ala Ala Arg Thr Leu Ala Glu Leu Arg Glu His Glu Gly Asp Gly 125 130 135 Val Phe Asp Leu Val Phe Val Asp Ala Asp Lys Thr Gly Tyr Pro 140 145 150 His Tyr Tyr Glu Gln Ala Leu Ala Leu Val Arg Pro Gly Gly Leu 155 160 165 Val Ala Ile Asp Asn Thr Leu Phe Phe Gly Arg Val Ala Asp Pro 170 175 180 Ala Val Asp Asp Ala Asp Thr Val Ala Val Arg Arg Leu Asn Asp 185 190 195 Leu Leu Arg Asp Asp Glu Arg Val Asp Ile Ala Leu Leu Thr Ile 200 205 210 Ala Asp Gly Ile Thr Leu Ala Arg Arg Arg Glu 215 220 <210> 8 <211> 449 <212> Pro <213> Streptomyces spiramyceticus WSJ-1£© <400> 1 Met Pro Glu Ser His Ala Gln Ser Ala Leu Leu Ala Ala Ile Thr 5 10 15 Ala Pro Asp Arg Thr Pro Glu Asp Ile Ala Ala Leu Arg Leu Pro 20 25 30 Glu Ser Phe Arg Ala Val Thr Val Arg Lys Glu Asp Thr Asp Met 35 40 45 Phe Arg Gly Met Thr Ser Thr Asp Lys Asp Pro Arg Lys Ser Leu 50 55 60 Arg Val Asp Glu Val Pro Leu Pro Glu Leu Gly Pro Gly Glu Ala 65 70 75 Leu Ile Ala Val Met Ala Ser Ser Val Asn Tyr Asn Thr Val Trp 80 85 90 Ser Ser Ile Phe Glu Pro Leu Pro Thr Phe Gly Phe Leu Glu Arg 95 100 105 Tyr Gly Arg Thr Ser Pro Ser Ala Ala Arg His Asp Leu Pro Tyr 110 115 120 His Ile Leu Gly Ser Asp Leu Ala Gly Val Val Leu Arg Thr Gly 125 130 135 Pro Gly Val Asn Val Trp Lys Pro Gly Asp Glu Val Val Ala His 140 145 150 Cys Leu Ser Val Glu Leu Glu Ser Ala Asp Gly His Asp Asp Thr 155 160 165 Met Leu Asp Pro Ala Gln Arg Ile Trp Gly Phe Glu Thr Asn Phe 170 175 180 Gly Gly Leu Ala Glu Val Ala Leu Val Lys Ser Asn Gln Leu Met 185 190 195 Pro Lys Ala Ala His Leu Thr Trp Glu Glu Ala Ala Ala Pro Gly 200 205 210 Leu Val Asn Ser Thr Ala Tyr Arg Gln Leu Val Ser Arg Asn Gly 215 220 225 Ala Gly Met Lys Gln Gly Asp Asn Val Leu Ile Trp Gly Ala Ser 230 235 240 Gly Gly Leu Gly Ser Tyr Ala Thr Gln Leu Ala Leu Ala Gly Gly 245 250 255 Ala Asn Pro Val Cys Val Val Ser Ser Glu Arg Lys Ala Gln Val 260 265 270 Cys Arg Ala Met Gly Ala Glu Ala Ile Ile Asp Arg Ser Ala Glu 275 280 285 Asp Tyr Arg Phe Trp Thr Asp Glu Asp Thr Gln Asn Pro Arg Glu 290 295 300 Trp Lys Arg Phe Gly Gly Arg Ile Arg Glu Leu Thr Gly Gly Glu 305 310 315 Asp Val Asp Ile Val Phe Glu His Pro Gly Arg Glu Thr Phe Gly 320 325 330 Ala Ser Val Tyr Val Thr Arg Arg Gly Gly Thr Ile Val Thr Cys 335 340 345 Ala Ser Thr Ser Gly Phe Arg His Glu Phe Asp Asn Arg Tyr Leu 350 355 360 Trp Met His Leu Lys Arg Ile Val Gly Thr His Phe Ala Asn Tyr 365 370 375 Arg Glu Ala Trp Glu Ala Asn Arg Leu Val Ala Lys Gly Lys Ile 380 385 390 His Pro Thr Leu Ser Cys Thr Tyr Pro Leu Ala Asp Thr Ala Leu 395 400 405 Ala Val His Asp Val His Ser Asn Leu His Gln Gly Lys Val Gly 410 415 420 Val Leu Cys Leu Ala Pro Thr Glu Gly Leu Gly Val Arg Asp Glu 425 430 435 Glu Lys Arg Ala Lys His Ile Asp Ala Ile Asn Arg Phe Arg 440 445 <210> 9 <211> 421 121 Pro <213> Streptomyces spiramyceticus WSJ-1£© <400> 1 Met Arg Val Leu Leu Thr Ser Leu Ala His Asn Thr His Tyr Tyr 5 10 15 Ser Leu Val Pro Leu Ala Trp Ala Leu Arg Ala Ala Gly His Glu 20 25 30 Val Arg Val Ala Ser Pro Pro Ser Leu Thr Asp Val Ile Thr Ser 35 40 45 Thr Gly Leu Thr Ala Val Pro Val Gly Asp Asp Arg Pro Ala Ala 50 55 60 Glu Leu Leu Ala Glu Met Gly Ser Asp Leu Val Pro Tyr Gln Arg 65 70 75 Gly Phe Glu Phe Gly Glu Val Glu Ser Glu Glu Glu Thr Thr Trp 80 85 90 Glu Tyr Leu Leu Gly Gln Gln Ser Met Met Ala Ala Leu Cys Phe 95 100 105 Ala Pro Phe Asn Gly Ala Ala Thr Met Asp Glu Ile Val Asp Phe 110 115 120 Ala Arg Gly Trp Arg Pro Asp Leu Val Val Trp Glu Pro Trp Thr 125 130 135 Tyr Ala Gly Pro Val Ala Ala Arg Ala Cys Gly Ala Ala His Ala 140 145 150 Arg Ile Leu Trp Gly Pro Asp Ala Ile Gly Arg Ser Arg Arg Arg 155 160 165 Phe Leu Ala Ala Leu Glu Gln Val Pro Glu Glu Leu Arg Glu Asp 170 175 180 Pro Ile Ala Glu Trp Leu Gly Trp Thr Leu Asp Arg Tyr Gly Tyr 185 190 195 Ala Phe Asp Glu Arg Asp Val Leu Gly His Trp Val Ile Asp Pro 200 205 210 Gly Pro Arg Ser Thr Arg Leu Asp Leu Gly Gln Thr Met Val Pro 215 220 225 Met Cys Tyr Val Pro Tyr Asn Gly Arg Ser Val Ile Glu Pro Trp 230 235 240 Leu Ala Lys Lys Pro Asp Arg Pro Arg Val Cys Leu Thr Leu Gly 245 250 255 Val Ser Ala Arg Glu Thr Tyr Gly Arg Asp Ala Val Ser Tyr Ser 260 265 270 Glu Leu Leu Glu Ala Leu Gly Arg Leu Asp Ile Glu Val Val Ala 275 280 285 Thr Leu Asp Ala Ser Gln Arg Glu Arg Leu Gly Val Leu Pro Asp 290 295 300 Asn Val Val Pro Val Asp Phe Val Pro Leu Asp Ala Leu Leu Pro 305 310 315 Ser Cys Ala Ala Ile Ile His His Gly Gly Ala Gly Thr Trp Ser 320 325 330 Thr Ala Leu Leu His Gly Val Pro Gln Ile Leu Leu Pro Ser Leu 335 340 345 Trp Asp Ala Pro Leu Lys Ala Gln Gln Leu Gln Arg Leu Ser Ala 350 355 360 Gly Phe Asp Leu Pro Ala Ala Thr Leu Thr Ala Arg Gly Leu Ala 365 370 375 Asp Ala Val His Thr Ala Val His Asp Pro Ala Ile Lys Ala Gly 380 385 390 Ala Arg Arg Leu Ser Glu Glu Met Leu Ala Asp Pro Thr Pro Ala 395 400 405 Gly Ile Val Pro Thr Leu Glu Arg Leu Thr Ala Leu His Arg Ala 410 415 420 Thr <210> 10 <211> 415 <212> Pro <213> Streptomyces spiramyceticus WSJ-1£© <400> 1 Met Glu Pro Ala Pro Ala Ser Ala Gly Thr Arg Glu Leu Gly Arg 5 10 15 Arg Leu Gln Leu Thr Arg Ala Ala His Trp Cys Ala Gly Asn Gln 20 25 30 Gly Asp Pro Tyr Ala Leu Ile Leu Arg Ala Val Ser Asp Pro Glu 35 40 45 Pro Leu Glu Arg Glu Ile Cys Ala Ala Gly Pro Trp Phe His Ser 50 55 60 Glu Leu Leu Gly Ala Trp Val Thr Ala Asp Pro Glu Val Ala Ala 65 70 75 Ala Val Leu Ala Asp Pro Arg Phe Gly Thr Leu Asp Arg Ala Gly 80 85 90 Arg Arg Pro Asp Glu Glu Leu Leu Pro Leu Ala Glu Ala Phe Pro 95 100 105 Arg His Glu Arg Ala Glu Leu Val Arg Leu Arg Ala Leu Ala Asp 110 115 120 Pro Val Leu Asn Arg Cys Ala Pro Ala Glu Ala Pro Cys Ala Ala 125 130 135 Arg Thr Thr Ala Arg Arg Val Leu Arg Arg Leu Leu Pro Thr Gly 140 145 150 Gly Ala Gly Phe Asp Leu Val Thr Glu Val Ala Arg Pro Tyr Ala 155 160 165 Val Glu Leu Val Leu Gly Phe Leu Gly Val Pro Asp Arg Asp Arg 170 175 180 Asp Ala Ala Ala Arg Ala Leu Ala Ala Cys Ala Pro Gln Leu Asp 185 190 195 Ala Arg Leu Ala Pro Gln Ile Leu Ala Val Ala Arg Glu Ser Ala 200 205 210 Asp Ala Val Arg Thr Leu Ala Asp Leu Val Pro Glu Leu Val Ala 215 220 225 Glu Lys Leu Arg Ala Val Glu Ser Gly Gly Pro Arg Pro Asp Asp 230 235 240 Val Leu Ala Leu Leu Leu Arg Asp Gly Val Ala Pro Arg Asp Val 245 250 255 Glu Arg Ile Ala Leu Val Leu Ala Ile Gly Ala Pro Glu Pro Ala 260 265 270 Ala Thr Ala Val Ala His Thr Val His Arg Leu Leu Gly Arg Pro 275 280 285 Gly Glu Trp Glu Arg Ala Arg Arg Thr Pro Ala Ala Ala Arg Ala 290 295 300 Val Glu Gln Thr Leu Arg His Arg Pro Pro Ala Arg Leu Glu Ser 305 310 315 Arg Val Ala His Thr Asp Leu Glu Leu Gly Gly Arg Arg Ile Ala 320 325 330 Ala Asp Glu His Ile Val Val Leu Ala Ala Ala Gly Arg Glu Thr 335 340 345 Pro Gly Pro Glu Pro Leu Gly Gly Pro Asp Gly Pro His Leu Ala 350 355 360 Leu Ala Leu Pro Leu Ile Arg Leu Ala Thr Thr Thr Ala Val Gln 365 370 375 Val Met Ala Gly Arg Leu Pro Gly Leu Arg Ala Glu Gly Ala Pro 380 385 390 Leu Thr Arg Pro Arg Ser Pro Val Val Gly Ala Cys Ala Arg Leu 395 400 405 Arg Val His Pro Gly Arg Val His Pro Gly 410 415 <210> 11 <211> 237 <212> Pro <213> Streptomyces spiramyceticus WSJ-1£© <400> 1 Met Tyr Ala Asn Asp Ile Ala Ala Val Tyr Asp Leu Val His Glu 5 10 15 Gly Lys Gly Lys Asp Tyr Arg Gln Glu Ala Glu Glu Ile Ala Ala 20 25 30 Leu Val Arg Val His Arg Pro Asp Thr Arg Ser Leu Leu Asp Val 35 40 45 Ala Cys Gly Thr Gly Gln His Leu Arg His Leu Asp Gly Leu Phe 50 55 60 Asp His Val Glu Gly Leu Glu Leu Ser His Asp Met Leu Ala Leu 65 70 75 Ala Thr Asp Arg Asn Pro Gly Val Thr Phe His Glu Gly Asp Met 80 85 90 Arg Ser Phe Ala Leu Gly Arg Arg Phe Asp Ala Val Ile Cys Met 95 100 105 Phe Ser Ser Ile Gly His Leu Arg Thr Thr Asp Glu Leu Asp Ser 110 115 120 Thr Leu Arg Ser Phe Thr Asp His Leu Glu Pro Gly Gly Val Ile 125 130 135 Val Val Glu Pro Trp Trp Phe Pro Ser Ser Phe Thr Pro Gly Tyr 140 145 150 Val Gly Ala Ser Val Thr Glu Ala Gly Glu Arg Thr Ile Cys Arg 155 160 165 Val Ser His Ser Val Arg Glu Gly Asn Ala Thr Arg Ile Glu Val 170 175 180 His Tyr Leu Val Ala Glu Pro Gly Gly Gly Ile Arg His Leu Thr 185 190 195 Glu Asp His Ala Ile Thr Leu Phe Pro Arg Ala Asp Tyr Glu Ala 200 205 210 Ala Phe Glu Arg Ala Gly Cys Asp Val Val Tyr Gln Glu Gly Gly 215 220 225 Pro Ser Gly Arg Gly Leu Phe Ile Gly Thr Arg Arg 230 235 <210> 12 <211> 1890 <212> Pro <213> Streptomyces spiramyceticus WSJ-1£© <400> 1 Met Ser Pro Ser Met Asp Glu Val Leu Gly Ala Leu Arg Thr Ser 5 10 15 Val Lys Glu Thr Glu Arg Leu Arg Arg His Asn Arg Glu Leu Leu 20 25 30 Ala Ala Ala His Glu Pro Val Ala Ile Val Gly Met Ala Cys Arg 35 40 45 Tyr Pro Gly Gly Val Thr Thr Pro Asp Asp Leu Trp Glu Leu Ala 50 55 60 Ala Asp Gly Val Asp Ala Ile Thr Arg Phe Pro Ala Asp Arg Gly 65 70 75 Trp Asp Glu Ala Ala Val Tyr Ser Pro Asp Pro Asp Thr Pro Gly 80 85 90 Thr Thr Tyr Cys Arg Glu Gly Gly Phe Leu Thr Gly Val Gly Asp 95 100 105 Phe Asp Ala Ala Phe Phe Gly Val Ser Pro Asn Glu Ala Leu Val 110 115 120 Met Asp Pro Gln Gln Arg Leu Leu Leu Glu Thr Ser Trp Glu Ala 125 130 135 Leu Glu Arg Ala Gly Val Val Pro Ala Ser Leu Arg Gly Ser Arg 140 145 150 Thr Gly Val Phe Val Gly Ala Ala His Thr Gly Tyr Val Ala Asp 155 160 165 Thr Ala Arg Ala Pro Glu Gly Thr Glu Gly Tyr Leu Leu Thr Gly 170 175 180 Asn Ala Asp Ala Val Met Ser Gly Arg Ile Ala Tyr Thr Leu Gly 185 190 195 Leu Glu Gly Pro Ala Leu Thr Ile Glu Thr Ala Cys Ser Ser Ser 200 205 210 Leu Val Ala Leu His Leu Ala Val Gln Ser Leu Arg Arg Gly Glu 215 220 225 Cys Asp Leu Ala Leu Ala Gly Gly Val Ala Val Met Pro Asp Pro 230 235 240 Thr Val Phe Val Glu Phe Ser Arg Gln Arg Gly Leu Ala Ser Asp 245 250 255 Gly Arg Cys Lys Ala Phe Ala Glu Gly Ala Asp Gly Thr Val Trp 260 265 270 Ala Glu Gly Val Gly Val Leu Leu Val Glu Arg Leu Ser Asp Ala 275 280 285 Arg Arg Tyr Gly His Arg Val Leu Ala Val Val Arg Gly Ser Ala 290 295 300 Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Ser Gly 305 310 315 Pro Ala Gln Arg Arg Val Ile Arg Glu Ala Leu Ala Asp Ala Gly 320 325 330 Leu Ala Pro Gly Asp Val Asp Ala Val Glu Ala His Gly Thr Gly 335 340 345 Thr Ala Leu Gly Asp Pro Ile Glu Ala Gly Ala Leu Leu Ala Thr 350 355 360 Tyr Gly Arg Glu Arg Val Gly Asp Pro Leu Trp Leu Gly Ser Leu 365 370 375 Lys Ser Asn Ile Gly His Ala Gln Ala Ala Ala Gly Val Gly Gly 380 385 390 Val Ile Lys Met Val Glu Ala Met Arg His Ser Ser Leu Pro Arg 395 400 405 Thr Leu His Val Asp Ala Pro Ser Ser Lys Val Glu Trp Gly Ser 410 415 420 Gly Ser Val Glu Leu Leu Thr Glu Ala Arg Ser Trp Pro Arg Arg 425 430 435 Ala Gly Arg Val Arg Arg Ala Ala Val Ser Ala Phe Gly Val Ser 440 445 450 Gly Thr Asn Ala His Val Val Ile Glu Glu Pro Pro Ser Glu Ala 455 460 465 Asp Gly Ser Asp Gly Pro Ala Pro Asp Pro Arg Ile Thr Ala Ala 470 475 480 Thr Pro Leu Pro Trp Val Ile Ser Ala Arg Ser Glu Glu Ala Leu 485 490 495 Arg Gly Gln Ala Asp Arg Leu Ala Ala Leu Ala Arg Arg Gly Pro 500 505 510 Thr Glu Asp Thr Asp Ala Asp Leu Thr Thr Ala Val Asp Leu Gly 515 520 525 Tyr Ser Leu Ala Thr Thr Arg Glu Ala Leu Glu His Arg Ala Val 530 535 540 Ala Leu Val His Asp Ala Arg Ala Ala Arg Glu Asp Leu Ala Ala 545 550 555 Leu Ala Ala Gly Arg Thr Pro Glu Asn Met Val Thr Gly Val Ala 560 565 570 Arg Arg Gly Arg Gly Ile Ala Phe Leu Cys Ser Gly Gln Gly Ala 575 580 585 Gln Arg Leu Gly Ala Gly Gln Glu Leu Arg Arg Arg Phe Pro Val 590 595 600 Phe Ala Asp Ala Leu Asp Glu Ile Ala Ala Glu Phe Asp Ala His 605 610 615 Leu Glu Arg Pro Leu Leu Ser Val Met Phe Ala Glu Pro Ser Ala 620 625 630 Pro Asp Ala Thr Leu Leu Asp Arg Thr Asp Tyr Thr Gln Pro Ala 635 640 645 Leu Phe Ala Val Glu Thr Ala Leu Phe Arg Leu Phe Glu Ser Trp 650 655 660 Gly Leu Val Pro Asp Val Leu Val Gly His Ser Ile Gly Gly Leu 665 670 675 Val Ala Ala His Ala Ala Gly Val Phe Ser Ala Ala Asp Ala Ala 680 685 690 Arg Leu Val Ala Ala Arg Gly Arg Leu Met Arg Ala Leu Pro Glu 695 700 705 Gly Gly Ala Met Ala Ala Val Gln Ala Thr Glu Arg Glu Val Ala 710 715 720 Ala Leu Glu Pro Val Val Ala Gly Gly Ala Val Ile Ala Ala Val 725 730 735 Asn Gly Pro Gln Ala Leu Val Leu Ser Gly Asp Glu Ala Ala Val 740 745 750 Leu Ala Ala Ala Gly Glu Leu Ala Ala Arg Gly Arg Arg Thr Lys 755 760 765 Arg Leu Arg Val Ser His Ala Phe His Ser Pro Arg Met Asp Ala 770 775 780 Met Leu Ala Asp Phe Arg Val Ile Ala Glu Thr Val Asp Tyr His 785 790 795 Ala Pro Arg Leu Pro Val Val Ser Glu Val Thr Gly Glu Leu Ala 800 805 810 Thr Ala Ala Gln Leu Arg Asp Pro Gly Tyr Trp Thr Arg Gln Val 815 820 825 Arg Glu Pro Val Arg Phe Ala Asp Ala Val Arg Thr Ala Arg Ala 830 835 840 Arg Asp Ala Thr Thr Phe Ile Glu Leu Gly Pro Asp Ala Val Leu 845 850 855 Ser Gly Met Ala Glu Glu Ser Leu Ala Asp Glu Ala Asp Thr Val 860 865 870 Phe Ala Pro Ala Leu Arg Arg Gly Arg Pro Glu Gly Asp Thr Ala 875 880 885 Leu Arg Ala Ala Ala Arg Ala Phe Val Arg Gly Ala Asp Leu Asp 890 895 900 Trp Ser Ala Leu Tyr Ser Gly Thr Gly Ala Arg Arg Thr Asp Leu 905 910 915 Pro Thr Tyr Ala Phe Gln His Ser Arg Tyr Trp Leu Ala Pro Thr 920 925 930 Ala Ala Ser Pro Thr Val Ala Pro Ala Thr Ser Ala Pro Ser Ala 935 940 945 Gly Pro Val Ala Glu Ala Glu Gln Asp Asp Ala Leu Trp Ala Ala 950 955 960 Val His Ala Gly Asp Ala Ala Ser Ala Ala Ala Arg Leu Gly Ala 965 970 975 Asp Gly Ala Gly Ile Glu Ser Gln Leu Gln Ala Val Leu Pro His 980 985 990 Leu Ala Ala Trp His Asp Arg Arg Arg Thr Thr Ala Gln Thr Ala 995 1000 1005 Gly Leu Arg Tyr Arg Val Ala Trp Gln Ala Ile Ala Pro Asp Ala 1010 1015 1020 Val Arg Phe Ser Pro Ser Asp Arg Trp Leu Met Val Glu His Gly 1025 1030 1035 Gln Cys Thr Asp Ser Ala Asp Ala Ala Glu Arg Ala Leu Arg Ala 1040 1045 1050 Ala Gly Ala Glu Val Ile Arg Leu Val Arg Pro Leu Gly Gln Ala 1055 1060 1065 Ala Gly Ala Pro Arg Thr Asp Ala Leu Asp Arg Asp Ala Leu Ala 1070 1075 1080 Ala Arg Leu Ala Glu Leu Ala Arg Ser Pro Glu Ser Leu Ala Gly 1085 1090 1095 Val Leu Leu Leu Pro Asp Thr Gly Gly Ala Thr Leu Ala Gly His 1100 1105 1110 Pro Gly Leu Asp Glu Gly Thr Thr Ala Val Leu Leu Met Val Gln 1115 1120 1125 Ala Met Ala Asp Ala Ala Val Glu Thr Pro Leu Trp Val Ala Thr 1130 1135 1140 Arg Gly Ala Val Ala Val Gly Pro Gly Glu Val Pro Cys Ala Met 1145 1150 1155 Gly Ala Arg Val Trp Gly Leu Gly Arg Val Ala Ala Leu Glu Ala 1160 1165 1170 Pro Val Gln Trp Gly Gly Leu Val Asp Leu Pro Ala Glu Pro Gly 1175 1180 1185 Gly Arg Asp Trp Arg Arg Leu Ala Ala Val Val Ser Gly Arg Gly 1190 1195 1200 Gly Glu Asp Gln Val Ala Ile Arg Gly Ser Gly Leu Phe Gly Arg 1205 1210 1215 Arg Leu Leu Pro Ala Ala Val Pro Ser Ala Ser Arg Ser Trp Arg 1220 1225 1230 Pro Arg Gly Cys Val Leu Val Thr Gly Gly Leu Gly Gly Val Gly 1235 1240 1245 Gly His Val Ala Arg Trp Leu Ala Arg Gly Gly Ala Glu His Val 1250 1255 1260 Val Leu Ala Gly Arg Arg Gly Gly Gly Ala Pro Gly Ala Val Glu 1265 1270 1275 Leu Glu Arg Glu Leu Val Gly Leu Gly Ala Lys Val Thr Phe Val 1280 1285 1290 Ala Cys Asp Val Ala Asp Arg Ala Ser Val Val Gly Leu Leu Gly 1295 1300 1305 Val Val Glu Gly Leu Gly Val Pro Leu Cys Gly Val Phe His Ala 1310 1315 1320 Ala Gly Val Ala Gln Val Ser Ala Leu Gly Glu Val Ser Leu Ala 1325 1330 1335 Glu Ala Ala Gly Val Leu Ala Gly Lys Ala Val Gly Ala Glu Leu 1340 1345 1350 Leu Asp Glu Leu Thr Ala Gly Val Asp Leu Asp Val Phe Val Leu 1355 1360 1365 Phe Ser Ser Gly Ala Ala Val Trp Gly Ser Gly Gly Gln Ser Val 1370 1375 1380 Tyr Ala Ala Ala Asn Ala His Leu Asp Ala Leu Ala Glu Arg Arg 1385 1390 1395 Arg Ala Gln Gly Arg Pro Ala Thr Ser Val Ala Trp Gly Val Trp 1400 1405 1410 Asp Gly Gly Gly Met Gly Glu Met Ala Pro Glu Gly Tyr Leu Ala 1415 1420 1425 Arg His Gly Leu Val Pro Leu Arg Pro Glu Thr Ala Leu Thr Ala 1430 1435 1440 Leu His Gln Ala Val Asp Ser Gly Asp Ala Thr Val Thr Val Ala 1445 1450 1455 Asp Leu Asp Trp Glu Arg Phe Ala Pro Gly Phe Thr Ala Phe Arg 1460 1465 1470 Pro Ser Pro Leu Ile Ser Gly Ile Pro Val Ala Arg Thr Ala Leu 1475 1480 1485 Ala Ala Ala Gly Gln Pro Ala Asp Asp Thr Pro Thr Ala Pro Asp 1490 1495 1500 Leu Val Arg Ala Arg Pro Glu Asp Arg Pro Arg Leu Ala Leu Glu 1505 1510 1515 Leu Val Leu Arg His Ile Ala Ala Val Leu Gly His Thr Glu Glu 1520 1525 1530 Asn Arg Gly Asp Ala Gln Ala Pro Phe Arg Asp Ile Gly Phe Asp 1535 1540 1545 Ser Leu Ala Ala Val Arg Leu Arg Gly Arg Leu Ala Glu Asp Thr 1550 1555 1560 Gly Leu Asp Leu Pro Ser Thr Leu Val Phe Asp His Glu Asp Pro 1565 1570 1575 Thr Ala Leu Ala His His Leu Ala Gly Leu Ala Asp Ala Gly Ala 1580 1585 1590 Thr Gly Arg His Glu Ser Ala Val Pro Ala Glu Ser Gly Leu Leu 1595 1600 1605 Ala Ser Phe Arg Ala Ala Val Glu Gln Ser Arg Ser Gly Glu Ala 1610 1615 1620 Val Glu Leu Met Ala Ser Leu Ala Ala Phe Arg Pro Ala Tyr Ser 1625 1630 1635 Arg Glu Gln Pro Gly Ser Ala Arg Pro Ala Pro Val Leu Leu Ala 1640 1645 1650 Thr Gly Pro Thr Thr His Pro Thr Leu Tyr Cys Cys Ala Gly Thr 1655 1660 1665 Ala Val Gly Ser Gly Pro Gly Glu Tyr Val Pro Phe Ala Glu Gly 1670 1675 1680 Leu Arg Asp Ser Arg Glu Thr Val Val Leu Pro Leu Ser Gly Phe 1685 1690 1695 Gly Gly Pro Ala Glu Pro Leu Pro Ala Ser Leu Asp Ala Leu Leu 1700 1705 1710 Asp Val Gln Ala Asp Val Leu Leu Glu His Ala Ala Gly Lys Pro 1715 1720 1725 Phe Ala Leu Ala Gly His Ser Ala Gly Ala Asn Val Ala His Ala 1730 1735 1740 Leu Ala Ala Arg Leu Glu Glu Arg Gly Thr Gly Pro Thr Ala Val 1745 1750 1755 Val Leu Met Asp Val Tyr Arg Pro Glu Asp Pro Gly Ala Met Gly 1760 1765 1770 Val Trp Arg Asp Asp Leu Leu Ser Arg Ala Leu Glu Arg Ser Thr 1775 1780 1785 Val Pro Leu Glu Asp His Arg Leu Thr Ala Met Ala Gly Tyr His 1790 1795 1800 Arg Leu Leu Leu Gly Ala Arg Leu Thr Ala Leu Asn Ala Pro Val 1805 1810 1815 Leu Leu Val Arg Ala Ser Glu Pro Leu Arg Glu Trp Pro Val Gly 1820 1825 1830 Glu Ala Gln Gly Asp Trp Arg Ser Arg Val Pro Phe Ala Arg Thr 1835 1840 1845 Val Ala Asp Val Pro Gly Asn His Phe Thr Met Leu Thr Glu His 1850 1855 1860 Ala Arg His Thr Ala Ser Val Val His Asp Trp Leu Glu Ala Val 1865 1870 1875 Pro His Pro Ala Gly Pro Pro Ala Leu Leu Thr Gly Gly Glu His 1880 1885 1890 <210> 13 <211> 1582 <212> Pro <213> Streptomyces spiramyceticus WSJ-1£© <400> 1 Met Ala Asn Glu Glu Lys Leu Arg Ala Tyr Leu Lys Arg Val Thr 5 10 15 Gly Glu Leu His Arg Ala Thr Glu Gln Leu Arg Thr Leu Asp Glu 20 25 30 Arg Ala His Glu Pro Ile Ala Ile Val Gly Ala Ala Cys Arg Leu 35 40 45 Pro Gly Gly Val Arg Ser Pro Asp Glu Leu Trp Asp Leu Leu Leu 50 55 60 Ala Gly Thr Asp Ala Val Ser Leu Ala Pro Ala Asp Arg Gly Trp 65 70 75 Asp Val Glu Ala Met Tyr Ser Pro Asp Pro Asp Thr Pro Gly Thr 80 85 90 Thr Tyr Cys Arg Glu Gly Gly Phe Val Gln Gly Ala Asp Arg Phe 95 100 105 Asp Pro Gly Leu Phe Gly Ile Ser Pro Asn Glu Ala Leu Thr Met 110 115 120 Asp Pro Gln Gln Arg Leu Leu Leu Glu Thr Ser Trp Glu Ala Leu 125 130 135 Glu Arg Ala Gly Leu Asp Pro Gln Ser Leu Ala Gly Ser Arg Thr 140 145 150 Gly Val Phe Ala Gly Ala Trp Glu Ser Gly Tyr Gln Lys Gly Val 155 160 165 Glu Gly Leu Glu Ala Glu Leu Glu Ala Gln Leu Leu Ala Gly Ile 170 175 180 Val Ser Phe Thr Ala Gly Arg Val Ala Tyr Ala Leu Gly Leu Glu 185 190 195 Gly Pro Ala Leu Thr Ile Asp Thr Ala Cys Ser Ser Ser Leu Val 200 205 210 Ala Leu His Leu Ala Val Gln Ser Leu Arg Arg Gly Glu Cys Asp 215 220 225 Leu Ala Leu Ala Gly Gly Ala Thr Val Ile Ala Asp Phe Ala Leu 230 235 240 Phe Thr Gln Phe Ser Arg Gln Arg Gly Leu Ala Pro Asp Gly Arg 245 250 255 Cys Lys Ala Phe Ala Glu Ala Ala Asp Gly Phe Gly Pro Ala Glu 260 265 270 Gly Ala Gly Met Leu Leu Val Glu Arg Leu Ser Glu Ala Gln Lys 275 280 285 Lys Gly His Pro Val Leu Ala Val Val Arg Gly Ser Ala Val Asn 290 295 300 Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Ser Gly Pro Ala 305 310 315 Gln Gln Lys Val Ile Arg Asp Ala Leu Ala Asp Ala Gly Leu Thr 320 325 330 Pro Ala Asp Val Asp Ala Val Glu Ala His Gly Thr Gly Thr Pro 335 340 345 Leu Gly Asp Pro Ile Glu Ala Ser Ala Leu Met Ala Thr Tyr Gly 350 355 360 Arg Glu Arg Ala Gly Asp Pro Leu Trp Leu Gly Ser Leu Lys Ser 365 370 375 Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ala Gly Val Ile 380 385 390 Lys Met Val Glu Ala Met Arg His Gly Thr Leu Pro Arg Thr Leu 395 400 405 His Ala Thr Thr Ala Ser Ser Lys Ile Glu Trp Gly Ala Gly Ala 410 415 420 Val Glu Leu Leu Ala Glu Ala Arg Pro Trp Pro Gln Arg Ala Asp 425 430 435 Gly Pro Arg Arg Ala Ala Ile Ser Ser Phe Gly Ile Ser Gly Thr 440 445 450 Asn Ala His Ile Val Val Glu Glu Ala Pro Thr Ala Arg Ala Glu 455 460 465 Pro Glu Glu Pro Glu Glu Pro Pro Val Ser Pro Thr Thr Val Leu 470 475 480 Pro Leu Ser Ala Ala Gly Ala Gln Pro Leu Arg Glu Gln Ala Arg 485 490 495 Arg Leu Ala Ala His Leu Ala Asp His Glu Glu Ile Thr Ala Ala 500 505 510 Asp Ala Ala Tyr Ser Ala Ala Thr Thr Arg Ala Ala Leu Ser Asn 515 520 525 Arg Ala Ser Val Leu Ala Asp Asp Arg Glu Ser Leu Ile Ala Arg 530 535 540 Leu Thr Ala Leu Ala Glu Gly Arg Arg Asp Val Asp Val Ala Val 545 550 555 Gly Glu Ala Gly Ser Gly Arg Pro Pro Val Phe Val Phe Pro Gly 560 565 570 Gln Gly Ser Gln Trp Thr Gly Met Gly Ala Glu Leu Leu Glu Ser 575 580 585 Ala Pro Ala Phe Arg Val Lys Ala Glu Glu Cys Ala Arg Ala Leu 590 595 600 Ala Ala His Leu Asp Trp Ser Val Leu Asp Val Leu Arg Gly Gly 605 610 615 Pro Asp Ala Pro Pro Ile Asp Arg Ala Asp Val Val Gln Pro Thr 620 625 630 Leu Phe Thr Met Met Val Ser Leu Ala Ala Leu Trp Glu Ala His 635 640 645 Gly Val Arg Pro Ala Ala Val Val Gly His Ser Gln Gly Glu Val 650 655 660 Ala Ala Ala Tyr Ala Ala Gly Ala Leu Ser Leu Asp Asp Ala Ala 665 670 675 Arg Val Ile Ala Glu Arg Ser Arg Leu Trp Gly Arg Leu Ala Gly 680 685 690 Asn Gly Gly Met Val Ser Val Met Ala Pro Ala Asp Arg Val Arg 695 700 705 Glu Leu Leu Glu Pro Trp Ala Glu Arg Ile Ser Val Ala Ala Val 710 715 720 Asn Gly Pro Ala Ser Val Thr Val Ala Gly Asp Ala Gln Ala Leu 725 730 735 Glu Glu Phe Gly Val Arg Leu Ser Ala Asp Gly Val Leu Arg Trp 740 745 750 Pro Leu Ala Gly Val Asp Phe Ala Gly His Ser Pro Gln Val Glu 755 760 765 Gln Phe Arg Thr Glu Leu Leu Gly Thr Leu Ala Asp Val Arg Pro 770 775 780 Thr Ala Ala Arg Leu Pro Phe Phe Ser Thr Val Thr Ala Gly Ala 785 790 795 His Asp Pro Glu Gly Leu Asp Ala Ala Tyr Trp Tyr Arg Asn Thr 800 805 810 Arg Glu Pro Val Glu Phe Glu Ser Thr Leu Arg Ala Leu Leu Arg 815 820 825 Gln Gly His Arg Thr Phe Val Glu Met Gly Pro His Pro Leu Leu 830 835 840 Gly Ser Ser Ile Asp Glu Ile Ala Glu Ala Glu Gly Val His Ala 845 850 855 Thr Ala Leu Ser Thr Leu His Arg Gly Ser Gly Gly Leu Asp Arg 860 865 870 Phe Arg Ala Ser Val Gly Ala Ala Phe Ala His Gly Val Arg Val 875 880 885 Asp Trp Ser Pro Leu Phe Glu Gly Ala Gly Ala Arg Arg Val Pro 890 895 900 Leu Pro Thr Tyr Ala Phe Arg Arg Asp Arg Phe Trp Leu Pro Thr 905 910 915 Ala Val Gly Arg Arg Thr Ala Lys Ala Pro Ala Asp Glu Ser Ala 920 925 930 Ala Trp Arg Tyr Arg Val Thr Trp Thr Ala Leu Glu Thr Gly Gly 935 940 945 Ser Gly Ala Pro Ser Gly Arg Trp Leu Leu Val Glu Leu Pro Gly 950 955 960 Ala Ala Pro Asp Glu Ala Asp Ala Ala Ala Thr Ala Leu Gly Thr 965 970 975 Ala Gly Ala Val Val Glu Arg Cys Pro Leu Asp Pro Ala Glu Val 980 985 990 Ala Arg Val Ala Leu Thr Glu Arg Leu Ala Glu Leu Ala Ala Gly 995 1000 1005 Pro Gln Gly Leu Ala Gly Val Leu Val Leu Pro Gly Arg Ala Ala 1010 1015 1020 Asp Ala Ala Pro Ala Asp Ala Phe Pro Leu Asp Pro Gly Thr Ala 1025 1030 1035 Ala Val Leu Leu Val Thr Gln Ala Val Thr Asp Gly Ala Pro Lys 1040 1045 1050 Ala Arg Val Trp Val Ala Thr Arg Gly Ala Val Ala Val Gly Pro 1055 1060 1065 Gly Glu Val Pro Cys Ala Met Gly Ala Arg Val Trp Gly Leu Gly 1070 1075 1080 Arg Val Ala Ala Leu Glu Ala Pro Val Gln Trp Gly Gly Leu Val 1085 1090 1095 Asp Leu Pro Ala Glu Pro Gly Gly Arg Asp Trp Arg Arg Leu Ala 1100 1105 1110 Ala Val Val Ser Gly Arg Gly Gly Glu Asp Gln Val Ala Ile Arg 1115 1120 1125 Gly Ser Gly Leu Phe Gly Arg Arg Met Leu Pro Ala Ala Pro Gly 1130 1135 1140 Val Arg Arg Arg Ser Trp Arg Pro Arg Gly Cys Val Leu Val Thr 1145 1150 1155 Gly Gly Leu Gly Gly Val Gly Gly His Val Ala Arg Trp Leu Ala 1160 1165 1170 Arg Gly Gly Ala Glu His Val Val Leu Ala Gly Arg Arg Gly Gly 1175 1180 1185 Gly Ala Pro Gly Ala Val Glu Leu Glu Arg Glu Leu Val Gly Leu 1190 1195 1200 Gly Ala Lys Val Thr Phe Val Ala Cys Asp Val Ala Asp Arg Ala 1205 1210 1215 Ser Val Val Gly Leu Leu Gly Val Val Glu Gly Leu Gly Val Pro 1220 1225 1230 Leu Cys Gly Val Phe His Ala Ala Gly Val Ala Gln Val Ser Ala 1235 1240 1245 Leu Gly Glu Val Ser Leu Ala Glu Ala Ala Gly Val Leu Ala Gly 1250 1255 1260 Lys Ala Val Gly Ala Glu Leu Leu Asp Glu Leu Thr Ala Gly Val 1265 1270 1275 Asp Leu Asp Val Phe Val Leu Phe Ser Ser Gly Ala Ala Val Trp 1280 1285 1290 Gly Ser Gly Gly Gln Ser Val Tyr Ala Ala Ala Asn Ala His Leu 1295 1300 1305 Asp Ala Leu Ala Glu Arg Arg Arg Ala Gln Gly Arg Pro Ala Thr 1310 1315 1320 Ser Val Ala Trp Gly Leu Trp Asp Gly Gly Gly Met Gly Ala Gly 1325 1330 1335 Asp Gly Val Arg Asp Phe Tyr Thr Glu Arg Gly Leu Ala Pro Met 1340 1345 1350 Arg Pro Glu Ser Gly Ile Glu Ala Leu His Thr Ala Leu Asn Gln 1355 1360 1365 Asp Asp Thr Cys Val Thr Val Ala Asp Ile Asp Trp Glu His Phe 1370 1375 1380 Val Thr Gly Phe Thr Ala Phe Arg Pro Ser Pro Leu Ile Ser Gly 1385 1390 1395 Ile Pro Gln Val Arg Ala Leu Arg Ala Ala Gln Pro Thr Val Gly 1400 1405 1410 Ala Ser Asp Asp Leu Arg Arg Arg Ile Asp Ala Ala Leu Thr Pro 1415 1420 1425 Arg Glu Arg Thr Lys Val Leu Val Asp Leu Val Arg Thr Val Ala 1430 1435 1440 Ala Glu Val Leu Gly His Asp Gly Ile Gly Arg Ile Gly His Asp 1445 1450 1455 Val Ala Phe Lys Glu Leu Gly Phe Asp Ser Leu Ala Ala Val Arg 1460 1465 1470 Val Arg Gly Arg Leu Ala Glu Ala Thr Gly Leu Val Leu Pro Ala 1475 1480 1485 Thr Ile Ile Phe Asp His Pro Thr Val Asp Arg Leu Gly Asn Ala 1490 1495 1500 Leu Leu Glu Glu Leu Thr Gly Ala Ser Asp Pro Glu Arg Gly Gly 1505 1510 1515 Ala Pro Gly Pro Ala Gly Thr Gly Gly Asn Asp Ala Ser Pro Pro 1520 1525 1530 Ala Pro Glu Pro Ala Ala His Asp Ala Glu Ile Asp Glu Leu Asp 1535 1540 1545 Ala Asp Ala Leu Val Arg Leu Ala Thr Gly Gly Thr Gly Pro Ala 1550 1555 1560 Asp Gly Ala Pro Ala Asn Asp Gly Ser Thr Glu Ala Gly Thr Thr 1565 1570 1575 Arg Gly Gly Ala Pro Glu Gln 1580 <210> 14 <211> 3795 <212> Pro <213> Streptomyces spiramyceticus WSJ-1£© <400> 1 Val Ser Ala Thr Asn Glu Glu Lys Leu Arg Glu Tyr Leu Arg Arg 5 10 15 Ala Met Ala Asp Leu His Ser Ala Arg Glu Arg Leu Arg Glu Val 20 25 30 Glu Ser Ala Ser Arg Glu Pro Ile Ala Ile Val Gly Met Ala Cys 35 40 45 Arg Tyr Pro Gly Gly Val Ala Ser Pro Glu Asp Leu Trp Asp Leu 50 55 60 Val Ala Ala Gly Thr Asp Ala Ile Ser Pro Phe Pro Ala Asp Arg 65 70 75 Gly Trp Asp Ala Glu Gly Leu Tyr Asp Pro Glu Pro Gly Val Pro 80 85 90 Gly Lys Ser Tyr Val Arg Glu Gly Gly Phe Leu His Glu Ala Ala 95 100 105 Glu Phe Asp Ala Glu Phe Phe Gly Ile Ser Pro Arg Glu Ala Ala 110 115 120 Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu Thr Ser Trp Glu 125 130 135 Ala Leu Glu Arg Ala Gly Ile Val Pro Asp Ser Leu Arg Gly Thr 140 145 150 Arg Thr Gly Val Phe Thr Gly Val Met Tyr His Asp Tyr Gly Ser 155 160 165 His Gln Val Gly Thr Ala Ala Asp Pro Ser Gly Gln Leu Gly Leu 170 175 180 Gly Thr Ala Gly Ser Val Ala Ser Gly Arg Val Ala Tyr Thr Leu 185 190 195 Gly Leu Gln Gly Pro Ala Val Thr Met Asp Thr Ala Cys Ser Ser 200 205 210 Ser Leu Val Ala Leu His Leu Ala Val Gln Ser Leu Arg Arg Gly 215 220 225 Glu Cys Asp Met Ala Leu Ala Gly Gly Val Thr Val Met Ala Thr 230 235 240 Pro Thr Val Phe Val Glu Phe Ser Arg Gln Arg Gly Leu Ala Ser 245 250 255 Asp Gly Arg Cys Lys Ala Phe Ala Glu Gly Ala Asp Gly Thr Val 260 265 270 Trp Ala Glu Gly Val Gly Val Leu Leu Val Glu Arg Leu Ser Asp 275 280 285 Ala Arg Arg Tyr Gly His Arg Val Leu Ala Val Val Arg Gly Ser 290 295 300 Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Ser 305 310 315 Gly Pro Ala Gln Arg Lys Val Ile Arg Glu Ala Leu Ala Asp Ala 320 325 330 Gly Leu Ala Pro Gly Asp Val Asp Ala Val Glu Ala His Gly Thr 335 340 345 Gly Thr Pro Leu Gly Asp Pro Ile Glu Ala Gly Ala Leu Met Ala 350 355 360 Thr Tyr Gly Ser Glu Arg Gln Gly Arg Asp Pro Leu Trp Leu Gly 365 370 375 Ser Leu Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Ala 380 385 390 Ala Gly Val Ile Lys Met Val Glu Ala Ile Arg His Ser Thr Leu 395 400 405 Pro Arg Thr Leu His Val Asp Ala Pro Ser Ala Lys Val Glu Trp 410 415 420 Asp Pro Ser Ala Val Glu Leu Leu Thr Asp Ala Arg Pro Trp Pro 425 430 435 Gln Arg Glu His Arg Pro Arg Arg Ala Ala Ile Ser Ala Phe Gly 440 445 450 Val Ser Gly Thr Asn Ala His Val Ile Ile Glu Glu Pro Pro Ala 455 460 465 Glu Thr Ala Thr Gly Gly Ala Ala Ala Ala Gly Asp Ala Pro Val 470 475 480 Ala Gly Glu Glu Pro Val Thr Gly Asp Ala Pro Val Thr Gly Glu 485 490 495 Val Pro Ala Ala Gly Ala Ala Ala Gly Thr Ser Val Ser Ser Val 500 505 510 Pro Gly His Ala Ser Val Pro Gly His Ala Ser Ala Pro Arg Val 515 520 525 Ala Ser Val Pro Gly His Ala Ser Ala Pro Arg Val Ala Ser Ala 530 535 540 Pro Gly His Ala Ser Ala Pro Arg Asp Ala Ser Ala Pro Arg Pro 545 550 555 Ala Ser Ala Pro Asp Glu Ala Ser Met Thr Gly Asp Thr Pro Ala 560 565 570 Thr Pro Ser Thr Val Val Trp Pro Leu Ser Ala Glu Thr Ala Pro 575 580 585 Ala Leu Arg Ala Gln Ala Ala Arg Leu Arg Ala His Leu Glu Arg 590 595 600 Leu Pro Asp Thr Ser Pro Thr Asp Ile Gly His Ala Leu Ala Ala 605 610 615 Asp Arg Ala Ala Leu Thr Gln Arg Ala Val Leu Leu Gly Asp Asn 620 625 630 Gly Ala Pro Val Asp Ala Leu Ala Ala Leu Ala Ala Gly Glu Thr 635 640 645 Thr Pro Asp Ala Val His Gly Thr Ala Ala Asp Ile Arg Arg Val 650 655 660 Ala Phe Val Phe Pro Gly Gln Gly Ser Gln Trp Ala Gly Met Gly 665 670 675 Ala Glu Leu Leu Asp Thr Ala Pro Ala Phe Ala Ala Glu Leu Glu 680 685 690 Leu Cys Gln Ser Ala Leu Ser Pro Tyr Val Asp Trp Thr Leu Ser 695 700 705 Asp Val Leu Arg Gly Ala Pro Gly Ala Pro Gly Leu Asp Arg Val 710 715 720 Asp Val Val Gln Pro Ala Thr Phe Ala Val Met Val Gly Leu Ala 725 730 735 Ala Leu Trp Arg Ser Leu Gly Val Glu Pro Ala Ala Val Ile Gly 740 745 750 His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val Ala Gly Ala Leu 755 760 765 Ser Leu Asp Asp Ala Ala Arg Ile Val Ala Leu Arg Ser Gln Val 770 775 780 Ile Ala Arg Glu Leu Ala Gly Arg Gly Gly Met Ala Ser Val Ala 785 790 795 Leu Pro Ala Thr Asp Val Glu Ala Arg Leu Ala Gly Gly Val Glu 800 805 810 Ile Ala Ala Val Asn Gly Pro Gly Ser Thr Val Val Cys Gly Glu 815 820 825 Pro Gly Ala Leu Glu Ala Leu Leu Val Ala Leu Glu Ala Glu Gly 830 835 840 Ser Arg Val Arg Arg Ile Asp Val Asp Tyr Ala Ser His Ser His 845 850 855 Tyr Val Glu Ser Ile Arg Glu Glu Leu Ala Thr Val Leu Ala Pro 860 865 870 Val Arg Pro Tyr Arg Gly Asp Val Pro Phe Tyr Ser Thr Val Glu 875 880 885 Ala Ala Leu Leu Asp Thr Ala Ala Leu Asp Ala Asp Tyr Trp Tyr 890 895 900 Arg Asn Leu Arg Leu Pro Val Arg Phe Glu Pro Thr Val Arg Ala 905 910 915 Met Leu Ala Asp Gly Ile Asp Ala Phe Val Glu Cys Ser Ala His 920 925 930 Pro Val Leu Thr Val Gly Val Arg Gln Thr Val Glu Ser Val Gly 935 940 945 Thr Ala Val Pro Ala Val Gly Ser Leu Arg Arg Asp Glu Gly Gly 950 955 960 Leu Arg Arg Phe Leu Thr Ser Ala Ala Glu Ala Gln Val Val Gly 965 970 975 Val Pro Val Asp Trp Ala Thr Leu His Pro Gly Ala Gly Arg Val 980 985 990 Asn Leu Pro Thr Tyr Ala Phe Gln Arg Glu Arg Tyr Trp Val Gly 995 1000 1005 Ser Ala Arg Pro Asp Arg Ala Lys Thr Ala Glu Thr Gly Glu Gly 1010 1015 1020 Ala Pro Glu Ser Gly Asp Arg Leu Gly Tyr His Val Glu Trp Lys 1025 1030 1035 Gly Leu Arg Ser Ala Thr Gly Gly Trp Arg Pro Gly Leu Arg Leu 1040 1045 1050 Leu Ile Val Pro Thr Gly Glu Gln His Ala Ala Leu Ala Asp Thr 1055 1060 1065 Val Glu Gln Ala Ile Ala Ser Phe Gly Gly Thr Val Arg Arg Ile 1070 1075 1080 Ala Val Asp Pro Ala Arg Thr Gly Arg Ala Glu Leu Leu Gly Leu 1085 1090 1095 Leu Glu Ser Ala Ile Asn Gly Asp Thr Ala Val Thr Gly Ala Val 1100 1105 1110 Ser Leu Leu Gly Leu Cys Thr Asp Gly Arg Pro Asp His Pro Ala 1115 1120 1125 Val Pro Thr Ala Val Thr Ala Thr Leu Ala Leu Val Gln Ala Leu 1130 1135 1140 Ala Asp Leu Gly Ser Thr Ala Pro Leu Trp Thr Val Thr Cys Gly 1145 1150 1155 Ala Val Ala Thr Ala Pro Asp Glu Leu Pro Cys Thr Ala Gly Ala 1160 1165 1170 Gln Leu Trp Gly Leu Gly Arg Val Ala Ala Leu Glu Leu Pro Glu 1175 1180 1185 Val Trp Gly Gly Leu Ile Asp Leu Pro Ala Gln Pro Asp Ala Arg 1190 1195 1200 Val Leu Asp Arg Leu Ala Gly Val Leu Ala Glu Pro Gly Gly Glu 1205 1210 1215 Asp Gln Ile Ala Ile Arg Met Ala Gly Val Phe Gly Arg Arg Val 1220 1225 1230 Leu Arg Asn Pro Ala Asp Ala Gly Ser Pro Ala Trp Arg Ala Arg 1235 1240 1245 Gly Thr Val Leu Ile Ala Gly Asp Ile Thr Thr Val Pro Gly Arg 1250 1255 1260 Leu Ile Arg Ser Leu Leu Glu Asp Gly Ala Asp Arg Val Val Leu 1265 1270 1275 Ala Gly Pro Asp Ala Pro Ala Gln Ala Ala Ala Ala Gly Leu Thr 1280 1285 1290 Gly Ala Ser Val Val Pro Val Arg Cys Asp Val Thr Asp Arg Thr 1295 1300 1305 Thr Leu Ala Gly Leu Leu Gly Glu His Ala Pro Ser Val Val Val 1310 1315 1320 His Ala Pro Pro Leu Val Pro Leu Ala Pro Leu Asn Glu Thr Ala 1325 1330 1335 Pro Gly Asp Ile Ala Thr Ala Leu Ala Ala Lys Thr Thr Ala Ala 1340 1345 1350 Gly His Leu Val Asp Leu Ala Pro Ala Ala Gly Leu Asp Ala Leu 1355 1360 1365 Val Leu Phe Ser Ser Val Ser Gly Val Trp Gly Gly Ala Ala Gln 1370 1375 1380 Gly Cys Tyr Ala Ala Ala Thr Ala His Leu Asp Ala Leu Ala Glu 1385 1390 1395 Arg Ala Arg Ala Ala Gly Val Pro Ala Leu Ser Val Ala Trp Ser 1400 1405 1410 Pro Trp Ala Gly Gly Thr Pro Ala Asp Gly Ala Glu Ala Glu Phe 1415 1420 1425 Leu Asn Arg Arg Gly Leu Ala Pro Leu Asp Pro Asp Glu Ala Val 1430 1435 1440 Arg Thr Leu Arg Arg Met Leu Glu Arg Gly Ser Ala Cys Gly Ala 1445 1450 1455 Val Ala Asp Val Glu Trp Asn Arg Phe Ala Ala Ser Tyr Thr Trp 1460 1465 1470 Val Arg Pro Ala Val Leu Phe Asp Asp Ile Pro Asp Val Gln Arg 1475 1480 1485 Leu Arg Ala Val Glu Leu Ala Pro Ser Asn Gly Asp Ser Thr Thr 1490 1495 1500 Ser Glu Leu Val Arg Glu Leu Thr Ala Gln Ser Gly His Lys Arg 1505 1510 1515 His Val Thr Leu Leu Arg Leu Val Arg Ala His Ala Ala Ala Val 1520 1525 1530 Leu Gly Gln Ser Ser Gly Asp Ala Val Asn Ser Ala Arg Ala Phe 1535 1540 1545 Arg Asp Leu Gly Phe Asp Ser Leu Thr Ala Leu Glu Leu Arg Asp 1550 1555 1560 Arg Leu Ser Thr Ala Thr Gly Leu Lys Leu Pro Thr Ser Leu Val 1565 1570 1575 Phe Asp His Ser Asn Pro Ala Ala Leu Ala Arg His Leu Gly Glu 1580 1585 1590 Glu Leu Leu Gly Arg Gly Asp Thr Ala Asp Arg Thr Gly Pro Glu 1595 1600 1605 Thr Pro Thr Gln Thr Asp Glu Pro Ile Ala Ile Ile Gly Met Ala 1610 1615 1620 Cys Arg Leu Pro Gly Gly Val Gln Ser Pro Glu Asp Leu Trp Asp 1625 1630 1635 Leu Leu Thr Gly Glu Val Asp Ala Ile Thr Pro Phe Pro Thr Asp 1640 1645 1650 Arg Gly Trp Asn Asn Glu Ala Leu Tyr Asp Pro Asp Pro Gly Ser 1655 1660 1665 Pro Gly His His Thr Tyr Val Arg Glu Gly Gly Phe Leu His Asp 1670 1675 1680 Ala Ala Glu Phe Asp Pro Gly Phe Phe Gly Ile Ser Pro Arg Glu 1685 1690 1695 Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Ile Leu Glu Thr Ser 1700 1705 1710 Trp Glu Ser Phe Glu Arg Ala Gly Ile Asp Pro Val Glu Leu Arg 1715 1720 1725 Gly Ser Arg Thr Gly Val Phe Val Gly Thr Asn Gly Gln His Tyr 1730 1735 1740 Val Pro Leu Leu Gln Asp Gly Asp Glu Ser Phe Asp Gly Tyr Ile 1745 1750 1755 Ala Thr Gly Asn Ser Ala Ser Val Met Ser Gly Arg Leu Ser Tyr 1760 1765 1770 Val Phe Gly Leu Glu Gly Pro Ala Val Thr Val Asp Thr Ala Cys 1775 1780 1785 Ser Ala Ser Leu Ala Ala Leu His Leu Ala Val Gln Ser Leu Arg 1790 1795 1800 Arg Gly Glu Cys Asp Tyr Ala Leu Ala Gly Gly Ala Thr Val Met 1805 1810 1815 Ser Thr Pro Glu Met Leu Val Glu Phe Ala Arg Gln Arg Ala Val 1820 1825 1830 Ser Pro Asp Gly Arg Ser Lys Ala Phe Ala Glu Thr Ala Asp Gly 1835 1840 1845 Val Gly Leu Ala Glu Gly Ala Gly Met Leu Leu Val Glu Arg Leu 1850 1855 1860 Ser Glu Ala Gln Lys Lys Gly His Pro Val Leu Ala Val Val Arg 1865 1870 1875 Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala 1880 1885 1890 Pro Ser Gly Pro Ala Gln Gln Lys Val Ile Arg Glu Ala Leu Ala 1895 1900 1905 Asp Ala Gly Leu Thr Pro Ala Asp Val Asp Ala Val Glu Ala His 1910 1915 1920 Gly Thr Gly Thr Pro Leu Gly Asp Pro Ile Glu Ala Gly Ala Leu 1925 1930 1935 Leu Ala Thr Tyr Gly Arg Asp Arg Arg Asp Asp Pro Leu Trp Leu 1940 1945 1950 Gly Ser Leu Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly 1955 1960 1965 Val Ala Gly Val Ile Lys Met Val Leu Ala Leu Arg His Gly Thr 1970 1975 1980 Leu Pro Arg Thr Leu His Ala Thr Thr Ala Ser Ser Lys Ile Glu 1985 1990 1995 Trp Asp Ala Gly Ala Val Glu Leu Leu Asp Glu Ala Arg Pro Trp 2000 2005 2010 Pro Gln Arg Ala Asp Gly Leu Arg Arg Ala Gly Ile Ser Ser Phe 2015 2020 2025 Gly Ile Ser Gly Thr Asn Ala His Val Val Val Glu Glu Pro Pro 2030 2035 2040 Glu Pro Thr Ala Pro Glu Leu Leu Ala Pro Glu Pro Ala Ala Asp 2045 2050 2055 Gly Asp Val Trp Ser Glu Glu Trp Trp His Glu Val Thr Val Pro 2060 2065 2070 Leu Met Met Ser Ala His Asn Asp Ala Ala Leu Arg Asp Gln Ala 2075 2080 2085 Arg Arg Leu Arg Ala Asp Leu Leu Ala His Pro Glu Leu His Pro 2090 2095 2100 Ala Asp Val Gly Tyr Thr Leu Ile Thr Thr Arg Thr Arg Phe Glu 2105 2110 2115 Gln Arg Ala Ala Val Val Gly Glu Asn Phe Thr Glu Leu Ile Ala 2120 2125 2130 Ala Leu Asp Asp Leu Val Glu Gly Arg Pro His Pro Leu Val Leu 2135 2140 2145 Arg Gly Thr Ala Gly Thr Ala Asp Gln Val Val Phe Val Phe Pro 2150 2155 2160 Gly Gln Gly Ser Gln Trp Pro Glu Met Ala Asp Gly Leu Phe Asp 2165 2170 2175 Arg Ser Ser Asp Ser Ser Ser Phe Leu Glu Thr Ala Arg Ala Cys 2180 2185 2190 Asp Ala Ala Leu Arg Pro His Leu Gly Trp Ser Val Leu Asp Val 2195 2200 2205 Leu Cys Arg Glu Pro Gly Ala Pro Ser Leu Asp Arg Val Asp Val 2210 2215 2220 Val Gln Pro Val Leu Phe Thr Met Met Val Ser Leu Ala Glu Thr 2225 2230 2235 Trp Arg Ser Leu Gly Val Glu Pro Ala Ala Val Val Gly His Ser 2240 2245 2250 Gln Gly Glu Ile Ala Ala Ala His Val Ala Gly Ala Leu Ser Leu 2255 2260 2265 Asp Asp Ala Ala Arg Ile Val Ala Leu Arg Ser Gln Ala Trp Leu 2270 2275 2280 Arg Leu Ala Gly Lys Gly Gly Met Val Ala Val Thr Met Ser Glu 2285 2290 2295 Arg Asp Leu Arg Pro Arg Leu Glu Pro Trp Ser Asp Arg Leu Ala 2300 2305 2310 Val Ala Ala Val Asn Gly Pro Glu Thr Cys Ala Val Ser Gly Asp 2315 2320 2325 Pro Asp Ala Leu Ala Glu Leu Val Ala Glu Leu Ser Ala Glu Gly 2330 2335 2340 Val His Ala Arg Pro Ile Pro Gly Val Asp Thr Ala Gly His Ser 2345 2350 2355 Pro Gln Val Asp Met Leu Glu Glu His Leu Arg Glu Val Leu Ala 2360 2365 2370 Pro Val Ala Pro Arg Ser Ser Asp Ile Pro Phe Tyr Ser Thr Val 2375 2380 2385 Thr Gly Gly Leu Leu Asp Thr Ala Glu Leu Asn Ala Asp Tyr Trp 2390 2395 2400 Tyr Arg Asn Met Arg Glu Pro Val Glu Phe Glu Lys Ala Thr Arg 2405 2410 2415 Ala Leu Ile Ala Asp Gly His Asp Val Phe Leu Glu Ser Ser Pro 2420 2425 2430 His Pro Met Leu Ala Val Ser Leu Gln Glu Thr Ile Ser Asp Ala 2435 2440 2445 Gly Ala Ser Ala Ala Val Leu Gly Thr Leu Arg Arg Gly Gln Gly 2450 2455 2460 Gly Pro Arg Cys Leu Ala Val Ala Val Cys Arg Ala Tyr Thr His 2465 2470 2475 Gly Val Glu Ile Asp Ala Glu Ala Ile Phe Gly Pro Asp Ser Arg 2480 2485 2490 His Val Glu Leu Pro Thr Tyr Pro Phe Gln Arg Glu Arg Tyr Trp 2495 2500 2505 Tyr Ser Pro Thr Ser Arg Gly Asp Asp Pro Ala Ser Leu Gly Leu 2510 2515 2520 Asp Ala Ala Asp His Pro Leu Leu Gly Gly Gly Val Glu Leu Pro 2525 2530 2535 Asp Ser Gly Ala Gln Met Tyr Thr Ala Arg Leu Gly Thr Asp Ala 2540 2545 2550 Thr Pro Trp Leu Ala Asp His Ala Leu Met Gly Ala Ala Leu Leu 2555 2560 2565 Pro Gly Ala Ala Phe Ala Asp Leu Ala Leu Trp Ala Gly Arg Gln 2570 2575 2580 Ala Gly Thr Gly Arg Ile Glu Glu Leu Thr Leu Ala Ala Pro Leu 2585 2590 2595 Ala Leu Pro Glu Ser Gly Gly Val Arg Leu Arg Leu Asn Val Gly 2600 2605 2610 Ala Pro Gly Ala Asp Asp Ala Arg Arg Phe Ala Val His Ala Arg 2615 2620 2625 Ala Glu Gly Ala Ala Asp Trp Thr Leu His Ala Glu Gly Leu Leu 2630 2635 2640 Thr Ala Glu Asp Ala Ala Asp Val Pro Asp Ala Ser Ala Thr Ala 2645 2650 2655 Pro Pro Pro Gly Ala Glu Gln Leu Asp Thr Gly Asp Phe Tyr Glu 2660 2665 2670 Arg Phe Ala Glu Leu Gly Tyr Gly Tyr Gly Pro Phe Phe Arg Gly 2675 2680 2685 Leu Val Ser Ala His Arg Ser Gly Ser Asp Ile His Ala Glu Val 2690 2695 2700 Ala Leu Pro Val Gln Ala Gln Gly Asp Ala Ala Arg Phe Gly Ile 2705 2710 2715 His Pro Ala Leu Leu Asp Ala Ala Leu Gln Thr Met Ser Leu Gly 2720 2725 2730 Gly Phe Phe Pro Glu Asp Gly Arg Ile Arg Met Pro Phe Ala Leu 2735 2740 2745 Arg Gly Val Arg Leu Tyr Arg Thr Gly Ala Glu Arg Leu His Val 2750 2755 2760 Arg Ile Ser Pro Val Ser Gln Asp Ala Val Arg Ile Arg Cys Ala 2765 2770 2775 Asp Thr Glu Gly Arg Ala Val Ala Glu Ile Asp Ser Phe Leu Met 2780 2785 2790 Arg Pro Val Asp Pro Glu Gln Leu Leu Gly Gly Arg Pro Val Gly 2795 2800 2805 Ala Asp Ala Leu Phe Arg Ile Ala Trp Arg Glu Leu Thr Ser Gly 2810 2815 2820 Ser Gly Thr Gly Leu Arg Thr Gly Asn Gly Ala Gly Ala Ala Ser 2825 2830 2835 Ser Val Arg Trp Val Val Ala Gly Pro Asp Val Leu Gly Leu Ala 2840 2845 2850 Glu Ala Ala Asp Ala His Leu Pro Asp Ala Leu Gly Pro Asp Gly 2855 2860 2865 Pro Leu Pro Thr Ala Ala Gly Glu Ala Ala Pro Asp Ala Phe Val 2870 2875 2880 Phe Gly Val Pro Thr Gly Thr Gly Asp Val Ala Ala Asp Ala His 2885 2890 2895 Ala Val Ala Cys Gln Val Leu Asp Leu Val Gln Arg Arg Leu Ala 2900 2905 2910 Ala Pro Asp Ala Pro Glu Gly Ala Arg Leu Val Val Ala Thr Arg 2915 2920 2925 Gly Ala Val Ala Val Arg Gly Asp Ala Glu Val Ser Asp Pro Ala 2930 2935 2940 Ala Ala Ala Ala Trp Gly Leu Leu Arg Ser Ala Gln Ala Glu Glu 2945 2950 2955 Pro Asp Arg Phe Leu Leu Val Asp Leu Asp Asp Asp Pro Ala Ser 2960 2965 2970 Ala Arg Ala Leu Pro Thr Ala Leu Ala Ser Gly Glu Pro Gln Thr 2975 2980 2985 Ala Val Arg Ala Gly Arg Val Tyr Val Pro Arg Leu Glu Arg Ala 2990 2995 3000 Ala Asp Ser Thr Asp Gly Pro Leu Thr Pro Pro Glu Lys Gly Ala 3005 3010 3015 Trp Arg Leu Gly Arg Gly Ala Asp Leu Thr Leu Asp Gly Leu Ala 3020 3025 3030 Leu Val Pro Ala Pro Asp Ala Glu Ala Pro Leu Glu His Gly Gln 3035 3040 3045 Val Arg Val Ala Val Arg Ala Ala Gly Val Asn Phe Arg Asp Ala 3050 3055 3060 Leu Ile Ala Leu Gly Met Tyr Pro Cys Glu Ala Glu Met Gly Thr 3065 3070 3075 Glu Gly Ala Gly Thr Val Val Glu Val Gly Pro Gly Val Thr Gly 3080 3085 3090 Val Ala Pro Gly Asp Arg Val Leu Gly Leu Trp Asn Gly Gly Leu 3095 3100 3105 Gly Pro Val Cys Val Ala Asp His Arg Leu Leu Val Pro Ile Pro 3110 3115 3120 Asp Gly Trp Ser Tyr Ala Arg Ala Ala Ser Val Pro Ala Val Phe 3125 3130 3135 Leu Ser Ala Tyr Tyr Gly Leu Val Thr Leu Ala Asp Leu Arg Pro 3140 3145 3150 Gly Glu Lys Val Leu Val His Ala Ala Ala Gly Gly Val Gly Met 3155 3160 3165 Ala Ala Val Gln Ile Ala Arg His Leu Gly Ala Glu Val Leu Ala 3170 3175 3180 Thr Ala Ser Thr Gly Lys Trp Asp Val Leu Arg Ala Met Gly Ile 3185 3190 3195 Thr Asp Glu His Leu Ala Ser Ser Arg Thr Leu Asp Phe Ala Thr 3200 3205 3210 Ala Phe Ala Gly Thr Asp Gly Thr Ser Arg Ala Asp Val Val Leu 3215 3220 3225 Asn Ser Leu Thr Lys Glu Phe Val Asp Ala Ser Leu Gly Leu Leu 3230 3235 3240 Arg Pro Gly Gly Arg Phe Leu Glu Leu Gly Lys Thr Asp Val Arg 3245 3250 3255 Asp Pro Glu Gln Val Gly Ala Asp His Pro Gly Val Arg Tyr Arg 3260 3265 3270 Ala Phe Asp Leu Asn Glu Ala Gly Pro Asp Glu Leu Gly Arg Leu 3275 3280 3285 Leu Arg Lys Leu Met Glu Leu Phe Ala Ala Gly Val Leu His Pro 3290 3295 3300 Leu Pro Val Val Thr His Asp Val Arg Arg Ala Ala Asp Ala Leu 3305 3310 3315 Arg Thr Ile Ser Gln Ala Arg His Thr Gly Lys Leu Val Leu Thr 3320 3325 3330 Met Pro Pro Ala Trp His Pro Tyr Gly Thr Val Leu Ile Thr Gly 3335 3340 3345 Gly Thr Gly Ala Leu Gly Gly Arg Ile Ala Arg His Leu Ala Thr 3350 3355 3360 His His Gly Val Arg Gln Leu Leu Ile Ala Ala Arg Arg Gly Pro 3365 3370 3375 Asp Gly Glu Gly Ala Ala Glu Leu Val Ala Asp Leu Thr Ala Leu 3380 3385 3390 Gly Ala Ser Ala Thr Val Val Ala Cys Asp Val Ser Asp Ala Asp 3395 3400 3405 Ala Val Arg Arg Leu Leu Ala Gly Val Pro Ala Glu His Pro Leu 3410 3415 3420 Thr Ala Val Val His Ser Ala Gly Val Leu Asp Asp Gly Val Leu 3425 3430 3435 Pro Thr Leu Thr Pro Glu Arg Met Arg Arg Val Leu Arg Pro Lys 3440 3445 3450 Val Glu Ala Ala Val His Leu Asp Glu Leu Thr Arg Asp Leu Asp 3455 3460 3465 Leu Ser Ala Phe Val Leu Phe Ser Ser Ser Ala Gly Leu Leu Gly 3470 3475 3480 Ser Pro Ala Gln Gly Asn Tyr Ala Ala Ala Asn Ala Thr Leu Asp 3485 3490 3495 Ala Leu Ala Val Arg Arg Arg Ala Leu Gly Leu Pro Ala Val Ser 3500 3505 3510 Leu Ala Trp Gly Leu Trp Ser Asp Thr Ser Arg Met Ala Gly Gly 3515 3520 3525 Leu Asp Gln Glu Ser Leu Gln Arg Arg Phe Ala Arg Asn Gly Phe 3530 3535 3540 Pro Pro Leu Ser Ala Thr Leu Gly Ala Ala Leu Phe Asp Ala Ala 3545 3550 3555 Leu Arg Val Asp Glu Ala Val Gln Ile Pro Met Arg Phe Asp Pro 3560 3565 3570 Ala Ala Leu Arg Ala Thr Gly Thr Val Pro Ala Leu Leu Ser Asp 3575 3580 3585 Leu Val Gly Pro Ala Pro Ala Ala Gly Ser Ala Thr Pro Ala Ala 3590 3595 3600 Gly Pro Tyr Pro Thr Pro Asp Ala Gly His Thr Gly Glu Pro Leu 3605 3610 3615 Ala Glu Arg Leu Ala Arg Leu Ser Ala Glu Glu Arg His Asp Gln 3620 3625 3630 Leu Leu Ser Leu Val Ser Glu His Val Ala Ala Val Leu Gly His 3635 3640 3645 Gly Ser Ala Ala Glu Val Arg Ser Asp Arg Pro Phe Arg Glu Val 3650 3655 3660 Gly Phe Asp Ser Leu Thr Ala Val Glu Leu Arg Asn Arg Met Gly 3665 3670 3675 Ala Val Thr Gly Val Arg Leu Pro Ala Thr Leu Val Phe Asp His 3680 3685 3690 Pro Thr Pro Ala Ala Leu Ala Ala His Leu Asp Gly Leu Leu Ala 3695 3700 3705 Pro Gln Arg Pro Pro Thr Thr Ala Pro Leu Leu Ser Glu Leu Asp 3710 3715 3720 Arg Ile Glu Glu Ala Leu Ala Ala Leu Thr Pro Glu Gly Leu Ala 3725 3730 3735 Ala Val Ala Pro Ala Pro Asp Ala Arg Ala Glu Val Ala Leu Arg 3740 3745 3750 Leu Asp Ala Leu Ala Asp Arg Trp Arg Ala Leu His Asp Gly Ala 3755 3760 3765 Ala Gly Val Asp Asp Asp Ile Ala Asp Val Leu Ser Thr Ala Asp 3770 3775 3780 Asp Asp Glu Ile Phe Ala Phe Ile Asp Glu Arg Tyr Gly Ala Ser 3785 3790 3795 <210> 15 <211> 2004 <212> Pro <213> Streptomyces spiramyceticus WSJ-1£© <400> 1 Met Thr Ala Glu Asn Asp Lys Ile Arg Ser Tyr Leu Lys Arg Ala 5 10 15 Thr Ala Glu Leu His Lys Thr Lys Ser Arg Leu Ala Glu Val Glu 20 25 30 Ser Ala Ser Arg Glu Pro Ile Ala Ile Val Gly Met Ala Cys Arg 35 40 45 Tyr Pro Gly Gly Val Ala Ser Pro Glu Asp Leu Trp Asp Leu Ala 50 55 60 Ala Ala Gly Ala Asp Ala Ile Ser Pro Phe Pro Val Asp Arg Gly 65 70 75 Trp Asp Val Glu Gly Leu Tyr Asp Pro Asp Pro Glu Ala Val Gly 80 85 90 Arg Ser Tyr Val Arg Glu Gly Gly Phe Leu His Gly Ala Ala Glu 95 100 105 Phe Asp Ala Glu Phe Phe Gly Ile Ser Pro Arg Glu Ala Ala Ala 110 115 120 Met Asp Pro Gln Gln Arg Leu Leu Leu Glu Thr Ser Trp Glu Ala 125 130 135 Leu Glu Arg Ala Gly Ile Val Pro Asp Ser Leu Arg Gly Thr Arg 140 145 150 Thr Gly Val Phe Thr Gly Val Met Tyr Asp Asp Tyr Gly Ser Gln 155 160 165 Phe Asp Ser Ala Pro Pro Glu Tyr Glu Gly Tyr Leu Val Asn Gly 170 175 180 Ser Ala Gly Ser Ile Ala Ser Gly Arg Val Ala Tyr Val Leu Gly 185 190 195 Leu Glu Gly Pro Ala Leu Thr Val Asp Thr Ala Cys Ser Ser Ser 200 205 210 Leu Val Ala Leu His Leu Ala Val Gln Ser Leu Arg Arg Gly Glu 215 220 225 Cys Asp Met Ala Leu Ala Gly Gly Val Thr Val Met Ala Thr Pro 230 235 240 Thr Val Phe Val Glu Phe Ser Arg Gln Arg Gly Leu Ala Ser Asp 245 250 255 Gly Arg Cys Lys Ala Phe Ala Glu Gly Ala Asp Gly Thr Val Trp 260 265 270 Ala Glu Gly Val Gly Val Leu Leu Val Glu Arg Leu Ser Asp Ala 275 280 285 Arg Arg Tyr Gly His Arg Val Leu Ala Val Val Arg Gly Ser Ala 290 295 300 Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Ser Gly 305 310 315 Ala Ala Gln Arg Arg Val Ile Arg Glu Ala Leu Ala Asp Ala Gly 320 325 330 Leu Ala Pro Gly Asp Val Asp Ala Val Glu Ala His Gly Thr Gly 335 340 345 Thr Ala Leu Gly Asp Pro Ile Glu Ala Gly Ala Leu Leu Ala Thr 350 355 360 Tyr Gly Arg Glu Arg Val Gly Asp Pro Leu Trp Leu Gly Ser Leu 365 370 375 Lys Ser Asn Ile Gly His Ala Gln Ala Ala Ala Gly Val Gly Gly 380 385 390 Val Ile Lys Met Val Glu Ala Met Arg His Ser Ser Leu Pro Arg 395 400 405 Thr Leu His Val Asp Ala Pro Ser Ser Arg Val Glu Trp Gly Ser 410 415 420 Gly Ala Val Glu Leu Leu Thr Glu Ala Arg Ser Trp Pro Arg Arg 425 430 435 Ala Gly Arg Val Arg Arg Ala Ala Val Ser Ala Phe Gly Val Ser 440 445 450 Gly Thr Asn Ala His Val Val Ile Glu Glu Pro Ser Val Glu Glu 455 460 465 Ser Ala Glu Ala Glu Ala Val Val Thr Ala Ala Ala Glu Ser Ser 470 475 480 Ser Val Leu Ala Trp Pro Val Ser Ala Arg Ser Glu Glu Ala Leu 485 490 495 Arg Gly Gln Ala Val Arg Leu Arg Glu His Val Glu Arg Val Gly 500 505 510 Ala Asp Pro Val Asp Val Ala His Ser Leu Val Val Ser Arg Ala 515 520 525 Ser Phe Gly Glu Arg Ala Val Val Val Gly Arg Glu Arg Gly Glu 530 535 540 Leu Leu Ala Gly Leu Asp Ala Val Ala Ala Gly Val Val Ala Ala 545 550 555 Gly Gly Ala Ala Ser Gly Val Val Arg Gly Ser Ala Val Arg Gly 560 565 570 Arg Arg Val Gly Val Leu Phe Thr Gly Gln Gly Ala Gln Trp Val 575 580 585 Gly Met Gly Arg Glu Leu Tyr Gly Ala Gly Gly Val Phe Ala Gly 590 595 600 Val Leu Asp Glu Val Leu Gly Val Val Gly Glu Val Gly Gly Arg 605 610 615 Ser Leu Arg Glu Val Met Phe Ala Glu Ala Gly Ser Val Asp Ala 620 625 630 Gly Leu Leu Gly Cys Thr Glu Phe Ala Gln Pro Ala Leu Phe Ala 635 640 645 Leu Glu Val Ala Leu Phe Arg Ala Leu Glu Ala Arg Gly Val Gly 650 655 660 Val Ser Val Val Leu Gly His Ser Val Gly Glu Val Ala Ala Ala 665 670 675 Tyr Val Ala Gly Val Phe Ser Leu Ala Asp Ala Val Arg Leu Val 680 685 690 Val Ala Arg Gly Arg Leu Met Gly Ala Leu Pro Val Gly Gly Ala 695 700 705 Met Val Ser Val Gly Ala Ser Glu Ala Glu Leu Ala Gly Leu Val 710 715 720 Ala Gly Leu Gly Gly Arg Val Ser Val Ala Ala Val Asn Gly Pro 725 730 735 Ala Ser Val Val Leu Ser Gly Glu Ala Gly Val Leu Asp Gly Val 740 745 750 Val Ala Gly Leu Val Gly Arg Gly Val Glu Cys Arg Trp Leu Glu 755 760 765 Val Ser His Ala Phe His Ser Val Leu Met Asp Pro Met Leu Glu 770 775 780 Glu Phe Arg Arg Val Ala Ala Ser Val Glu Phe His Arg Pro Arg 785 790 795 Ser Gly Val Ala Val Val Ser Ser Val Thr Gly Ala Val Ala Gly 800 805 810 Leu Asp Glu Leu Gly Asp Pro Glu Tyr Trp Val Arg His Val Arg 815 820 825 Glu Ala Val Arg Phe Ala Asp Gly Val Gly Ala Ala Arg Asp Val 830 835 840 Gly Val Asp Thr Phe Val Glu Val Gly Pro His Ala Val Leu Thr 845 850 855 Val Met Ala Gly Gln Cys Leu Asp Gly Asp Glu Gly Asp Leu Ala 860 865 870 Phe Val Pro Val Leu Arg Arg Asp Arg Pro Glu Leu Glu Thr Phe 875 880 885 Thr Thr Ala Leu Ala Thr Leu Tyr Ala Arg Gly Leu Pro Val Pro 890 895 900 Pro Ala Pro Ser Glu Pro Ala Gly Arg Arg Val Asp Leu Pro Thr 905 910 915 Tyr Ala Phe His Arg Asp Arg Tyr Trp Leu Ala Ala Leu Pro Arg 920 925 930 Leu Thr Thr Gly Gly Val Ser Ala Ala Gly Leu His Gly Val Glu 935 940 945 His Pro Leu Leu Ala Ala Ala Val Glu Leu Pro Gly Ala Glu Thr 950 955 960 Glu Val Trp Thr Gly Arg Ile Ser Ala Ala Asp Leu Pro Trp Leu 965 970 975 Ala Asp His Leu Val Trp Asp Arg Gly Val Val Pro Gly Ser Ala 980 985 990 Leu Leu Glu Met Leu Leu Gln Val Gly Ser Arg Ile Gly Leu Pro 995 1000 1005 Arg Val Ala Glu Leu Ala Phe Glu Thr Ala Leu Thr Trp Ala Ala 1010 1015 1020 Asp Asn Pro Val Gln Ile Arg Val Val Val Ala Ala Pro Ala Ser 1025 1030 1035 Gly Pro Gly Gly Ala Arg Glu Val Ser Leu His Ser Arg Pro Glu 1040 1045 1050 Pro Val Ala Asp Pro Ser His Ser Thr Arg Ser Pro His Leu Ala 1055 1060 1065 Ala Gln Asp Arg Asp Asn Gly Trp Thr Arg His Ala Ser Gly Leu 1070 1075 1080 Leu Ala Pro Ala Ala Asp His Ala Asp His Thr His Glu Ala Gly 1085 1090 1095 His Pro His Gly Ala Pro His Pro His Glu Ser Gly His Pro His 1100 1105 1110 Gly Ala Asp Arg Thr Gly Ala Asp Ala Phe Ala Glu Leu Thr Gly 1115 1120 1125 Ala Trp Pro Pro Ala Gly Ala Glu Pro Leu Asp Ile Ala Gly Gln 1130 1135 1140 Tyr Pro Leu Phe Ala Ala Ala Gly Val Arg Tyr Glu Gly Ala Phe 1145 1150 1155 Arg Gly Leu Arg Ala Ala Trp Arg Arg Gly Asp Glu Ile Phe Ala 1160 1165 1170 Glu Val Arg Leu Pro Asp Ala His Ala Ala Asp Ala Ala Arg Tyr 1175 1180 1185 Gly Val His Pro Ala Leu Leu Asp Ala Ala Leu His Pro Ile Ala 1190 1195 1200 Leu Leu Asp Pro Leu Gly Asp Gly Gly His Gly Leu Leu Pro Phe 1205 1210 1215 Ser Trp Thr Asp Val Arg Arg His Asp Ala Ala Gly His Ala Leu 1220 1225 1230 Arg Val Arg Val Ala Ala Val Asp Gly Gly Ala Val Ser Ile Ala 1235 1240 1245 Ala Val Asp Arg Glu Gly Ser Pro Val Leu Ser Ala Arg Ser Leu 1250 1255 1260 Ala Leu Arg Arg Ile Pro Ala Asp Arg Leu Pro Ala Ala Pro Ala 1265 1270 1275 Ala Pro Leu Tyr Arg Val Asp Trp Val Pro Leu Pro Gly Arg Val 1280 1285 1290 Ser Val Ala Ala Val Thr Arg Trp Ala Val Val Gly Pro Glu Ala 1295 1300 1305 Glu Ala Thr Ala Ala Gly Leu Arg Ala Val Gly Ile Asp Ala Arg 1310 1315 1320 Thr His Val Leu Pro Phe Asp Glu Pro Leu Pro Pro Gln Val Gly 1325 1330 1335 Ala Asp Ala Glu Val Ile Leu Leu Asp Leu Thr Thr Ala Thr Ala 1340 1345 1350 Thr Ala Thr Ala Thr Ala Ser Arg Thr Ala Pro His Gly Arg Leu 1355 1360 1365 Leu Gly Leu Leu Asp Glu Leu Arg Ala Thr Val Arg Arg Thr Leu 1370 1375 1380 Glu Ala Val Gln Ala Arg Leu Ala Asp Thr Asp Thr Asp Thr Asp 1385 1390 1395 Thr Asn Ala Asp Ala Gly Ala Asp Ser Gly Val Arg Thr Asp Ala 1400 1405 1410 Arg Thr Ala Thr Arg Pro Gly Gly Arg Pro Arg Leu Val Val Leu 1415 1420 1425 Thr Arg Gly Ala Ala Gly Pro Glu Gly Gly Ala Ala Asp Pro Ala 1430 1435 1440 Gly Ala Ala Val Trp Gly Leu Val Arg Val Ala Gln Ala Glu Gln 1445 1450 1455 Pro Gly Arg Phe Thr Leu Val Asp Val Asp Gly Ala Gln Ala Ser 1460 1465 1470 Leu Arg Ala Leu Pro Gly Leu Leu Ala Thr Asp Thr Ala Gln Leu 1475 1480 1485 Ala Val Arg Asp Gly Arg Ala Ala Val Pro Arg Leu Val Arg Val 1490 1495 1500 Ala Asp Val Ala Asp Val Ala Asp Leu Asp Thr Gly Ser Asp Thr 1505 1510 1515 Ala Ala Asp Glu Thr Gly Ala Gly Glu Pro Ala Glu Thr Leu Asp 1520 1525 1530 Pro Asn Gly Thr Val Leu Ile Thr Gly Gly Thr Gly Ala Leu Ala 1535 1540 1545 Ala Glu Thr Ala Arg His Leu Val Glu Arg His Lys Ala Arg His 1550 1555 1560 Leu Leu Leu Val Ser Arg Arg Gly Pro Asp Ala Pro Gly Ala Ala 1565 1570 1575 Glu Leu Ala Ala Glu Leu Thr Asn Leu Gly Ala Glu Val Thr Val 1580 1585 1590 Arg Ala Cys Asp Val Ala Asp Arg Asp Ala Leu Arg Arg Leu Leu 1595 1600 1605 Gly Glu Leu Pro Ala Glu His Pro Leu Thr Cys Val Val His Thr 1610 1615 1620 Ala Gly Val Leu Asp Asp Gly Val Leu Ser Val Gln Thr Ala Glu 1625 1630 1635 Arg Ile Asp Ala Val Leu Arg Pro Lys Ala Asp Ala Ala Val His 1640 1645 1650 Leu Asp Glu Leu Thr Arg Glu Leu Gly Pro Val Pro Leu Val Leu 1655 1660 1665 Tyr Ser Ser Val Ser Ala Ala Leu Gly Ser Ala Gly Gln Ala Gly 1670 1675 1680 Tyr Ala Ala Ala Asn Ala Phe Leu Asp Ala Leu Ala Ala Arg Arg 1685 1690 1695 Arg Ala Ala Gly His Pro Ala Leu Ser Leu Gly Trp Gly Trp Trp 1700 1705 1710 Ser Gly Leu Gly Leu Ala Thr Gly Leu Glu Arg Ala Asp Ala Ala 1715 1720 1725 Arg Ile Arg Arg Ser Gly Val Ala Pro Leu Asp Pro Arg Ala Ala 1730 1735 1740 Leu Glu Leu Phe Asp Arg Ala Leu Val Arg Pro Glu Pro Ala Leu 1745 1750 1755 Leu Pro Val Arg Leu Asp Leu Arg Ala Ala Ala Arg Ala Thr Val 1760 1765 1770 Leu Pro Glu Val Leu Arg Asp Leu Val Gly Val Pro Ala Asp Gly 1775 1780 1785 Gly Ser Ala Pro Gly Ala Val Ala Gly Ala Gly Gly Glu Ala Gly 1790 1795 1800 Thr Gly His Arg Pro Pro Ala Pro Ala Asp Ala Ala Ala Ala Leu 1805 1810 1815 Ala Thr Arg Leu Ala Gly Arg Ser Ala Pro Glu Arg Thr Ala Leu 1820 1825 1830 Leu Leu Asp Leu Val Arg Thr Glu Val Ala Ala Val Leu Gly His 1835 1840 1845 Gly Asp Thr Ala Ala Val Gly Ala Ala Arg Ser Phe Lys Asp Ala 1850 1855 1860 Gly Phe Asp Ser Leu Thr Ala Val Asp Leu Arg Asn Arg Leu Asn 1865 1870 1875 Ala Arg Thr Gly Leu Arg Leu Pro Ala Thr Leu Val Phe Asp His 1880 1885 1890 Pro Thr Pro Leu Ser Leu Ala Glu Leu Leu Leu Gly Glu Leu Thr 1895 1900 1905 Ala Ala Gly Arg Ala Glu Pro Ala Gly Pro Val Pro Asp Glu Pro 1910 1915 1920 Ala Gly Ala Glu Asp Leu Ser Ser Ala Phe Asp Arg Leu Glu Arg 1925 1930 1935 Ser Leu Ala Ala Thr Asp Asp Gly Asp Ala Arg Val Arg Ala Ala 1940 1945 1950 Gln Arg Leu Arg Gly Leu Leu Ala Ala Leu Thr Val Gly Ser Gly 1955 1960 1965 Glu Gln Ser Gly Pro Gly Ala Gly Glu Ser Pro His Gly Pro Gly 1970 1975 1980 Asp Val Val Ile Asp Arg Leu Arg Ser Ala Ser Asp Asp Asp Leu 1985 1990 1995 Phe Asp Leu Leu Asp Ser Asp Phe Gln 2000 <210> 16 <211> 4538 <212> Pro <213> Streptomyces spiramyceticus WSJ-1£© <400> 1 Met Ser Cys Arg Phe Pro Ser Ala Pro Gly Ile Gln Glu Phe Trp 5 10 15 Lys Leu Leu Thr Asp Gly Thr Glu Ala Ile Gly Arg Ala Ala Asp 20 25 30 Gly Arg Arg Arg Gly Met Ile Glu Ala Val Gly Asp Phe Asp Ala 35 40 45 Ala Phe Phe Gly Met Ser Pro Arg Glu Ala Ala Glu Thr Asp Pro 50 55 60 Gln Gln Arg Leu Met Leu Glu Leu Gly Trp Glu Ala Leu Glu Asp 65 70 75 Ala Gly Ile Val Pro Gly Ser Leu Arg Gly Glu Ala Val Gly Val 80 85 90 Phe Val Gly Ala Met Asn Asp Asp Tyr Ala Thr Leu Leu His Arg 95 100 105 Ala Gly Ala Pro Ile Gly Ala His Thr Ala Thr Gly Leu Gln Arg 110 115 120 Ala Met Leu Ala Asn Arg Leu Ser Tyr Val Leu Gly Thr Arg Gly 125 130 135 Pro Ser Leu Ala Val Asp Thr Ala Gln Ser Ser Ser Leu Val Ala 140 145 150 Val Ala Leu Ala Val Glu Ser Leu Arg Ala Gly Thr Ser Arg Ile 155 160 165 Ala Val Ala Gly Gly Val Asn Leu Ile Leu Ala Asp Glu Gly Ser 170 175 180 Ala Ala Met Glu Arg Leu Gly Ala Leu Ser Pro Asp Gly Arg Cys 185 190 195 His Thr Phe Asp Ala Arg Ala Asn Gly Tyr Val Arg Gly Glu Gly 200 205 210 Gly Ala Ala Val Val Leu Lys Pro Leu Ala Asp Ala Leu Ala Asp 215 220 225 Gly Asp Pro Val Tyr Cys Val Val Arg Gly Val Ala Ile Gly Asn 230 235 240 Asp Gly Gly Gly Pro Gly Leu Thr Ala Pro Asp Arg Glu Gly Gln 245 250 255 Glu Ala Val Leu Arg Ser Ala Cys Ala Gln Ala Gly Val Asp Pro 260 265 270 Ala Glu Val His Phe Val Glu Leu His Gly Thr Gly Thr Pro Val 275 280 285 Gly Asp Pro Val Glu Ala His Ala Leu Gly Ala Val His Gly Ser 290 295 300 Gly Arg Ser Ala Asp Thr Pro Leu Leu Val Gly Ser Val Lys Thr 305 310 315 Asn Ile Gly His Leu Glu Gly Ala Ala Gly Ile Ala Gly Leu Val 320 325 330 Lys Ala Val Leu Cys Leu Arg Glu Arg Thr Leu Pro Gly Ser Leu 335 340 345 Asn Phe Asp Thr Pro Asn Pro Ala Ile Pro Leu Asp Arg Leu Arg 350 355 360 Leu Lys Val Gln Thr Ala Pro Thr Glu Leu His Pro Gly Pro Ser 365 370 375 Gly Ala Pro Leu Leu Ala Gly Val Ser Ser Phe Gly Ile Gly Gly 380 385 390 Thr Asn Cys His Val Val Leu Glu His Leu Pro Gln Pro Ala Pro 395 400 405 Ala Gly Pro Asp Ala Ile Pro Ser Ser Ala Ser Glu Ala Ala Ala 410 415 420 Pro His Pro Ala Pro Pro Leu Leu Leu Ser Ala Arg Ser Arg Ala 425 430 435 Ala Leu Arg Ala Gln Ala Ala Arg Leu His Asp His Leu Gly Arg 440 445 450 Thr Gly Ala Asp Pro Arg Asp Ile Ala Tyr Ser Leu Ala Thr Thr 455 460 465 Arg Thr Leu Phe Glu His Arg Ala Ala Leu Arg Cys Gly Asp Arg 470 475 480 Glu Glu Leu Ala Ala Ser Leu Asp Ala Phe Ala Arg Gly Lys Thr 485 490 495 Ser Ala Gly Val Arg Thr Gly Thr Ala Val Ser Gly Gly Thr Ala 500 505 510 Val Leu Phe Thr Gly Gln Gly Ala Gln Trp Val Gly Met Gly Arg 515 520 525 Glu Leu Tyr Gly Ala Gly Gly Val Phe Ala Gly Val Leu Asp Glu 530 535 540 Val Leu Gly Val Val Gly Glu Val Gly Gly Arg Ser Leu Arg Glu 545 550 555 Val Met Phe Ala Glu Ala Gly Ser Val Gly Ala Gly Leu Leu Gly 560 565 570 Cys Thr Glu Phe Ala Gln Pro Ala Leu Phe Ala Leu Glu Val Ala 575 580 585 Leu Phe Arg Ala Leu Glu Ala Arg Gly Val Gly Val Ser Val Val 590 595 600 Leu Gly His Ser Val Gly Glu Val Ala Ala Ala Tyr Val Ala Gly 605 610 615 Val Phe Ser Leu Ala Asp Ala Val Arg Leu Val Val Ala Arg Gly 620 625 630 Arg Leu Met Gly Ala Leu Pro Val Gly Gly Ala Met Val Ser Val 635 640 645 Gly Ala Ser Glu Ala Glu Leu Ala Gly Leu Val Ala Gly Leu Gly 650 655 660 Gly Arg Val Ser Val Ala Ala Val Asn Gly Pro Ala Ser Val Val 665 670 675 Leu Ser Gly Glu Ala Gly Val Leu Asp Gly Val Val Ala Gly Leu 680 685 690 Val Gly Arg Gly Val Glu Cys Arg Trp Leu Glu Val Ser His Ala 695 700 705 Phe His Ser Val Leu Met Asp Pro Met Leu Glu Glu Phe Arg Arg 710 715 720 Val Ala Ala Ser Val Glu Phe His Arg Pro Arg Ser Gly Val Ala 725 730 735 Val Val Ser Ser Val Thr Gly Ala Val Ala Gly Leu Asp Glu Leu 740 745 750 Gly Asp Pro Glu Tyr Trp Val Arg His Val Arg Glu Ala Val Arg 755 760 765 Phe Ala Asp Gly Val Gly Ala Ala Arg Asp Val Gly Val Asp Thr 770 775 780 Phe Val Glu Val Gly Pro His Ala Val Leu Thr Val Met Ala Gly 785 790 795 Gln Cys Leu Asp Gly Asp Glu Gly Asp Leu Ala Phe Val Pro Val 800 805 810 Leu Arg Arg Asp Arg Pro Glu Leu Glu Thr Phe Thr Thr Ala Leu 815 820 825 Ala Thr Leu Tyr Thr Arg Asp Ala Glu Leu Asp Val Ala Ala Leu 830 835 840 His Ser Gly Phe Gly Gly Arg Arg Val Asp Leu Pro Thr Tyr Pro 845 850 855 Phe Gln Arg Arg Thr His Trp Ser Pro Ala Leu Ser Arg Gly Ile 860 865 870 Ala Ala Asp Ala Gly Pro Gly Leu Thr Thr Thr Asp Ala Ala Gly 875 880 885 Asn Thr Ala Pro Pro Glu Ser Thr Glu Ala Pro Leu Arg Asp Pro 890 895 900 Asp Asp Glu Pro Leu Thr Ala Ser Pro Glu Pro Met Ser Pro Glu 905 910 915 Gln Leu Val Arg Leu Val Arg Glu Thr Thr Ala Thr Val Leu Gly 920 925 930 His Asp Asp Pro Asp Glu Ile Ala Leu Asp Arg Thr Phe Thr Ser 935 940 945 Gln Gly Leu Glu Ser Ala Thr Ala Val Glu Leu His Asp Leu Leu 950 955 960 Asn Arg Ala Thr Gly Leu Thr Leu Ala Ala Thr Leu Val Tyr Asp 965 970 975 Leu Pro Thr Pro Arg Ala Val Ala Glu His Leu Val Ala Ala Leu 980 985 990 His Gly Thr Lys Ser Ala His Pro Gly Glu His Glu Ala Val Gly 995 1000 1005 Ala Ala Ala Ala Arg Gly Gly Thr Arg Asp Asp Asp Pro Ile Ala 1010 1015 1020 Ile Val Gly Val Gly Cys Arg Leu Pro Gly Gly Val Asp Ser Arg 1025 1030 1035 Ala Ala Leu Trp Asp Leu Leu Ala Ser Gly Thr Asp Ala Ile Ser 1040 1045 1050 Ser Phe Pro Ala Asp Arg Gly Trp Asp Leu Asp Gly Leu Tyr Asp 1055 1060 1065 Ala Glu Pro Gly Val Pro Gly Lys Thr Tyr Val Arg Gln Gly Gly 1070 1075 1080 Phe Leu His Gln Ala Ala Glu Phe Asp Ala Glu Phe Phe Gly Ile 1085 1090 1095 Ser Pro Arg Glu Ala Thr Ala Met Asp Pro Gln Gln Arg Leu Leu 1100 1105 1110 Leu Glu Thr Ser Trp Glu Ala Leu Glu Asp Ala Gly Val Leu Pro 1115 1120 1125 Glu Ser Leu Arg Gly Gly Asp Thr Gly Val Phe Ile Gly Ala Val 1130 1135 1140 Ala Pro Glu Tyr Gly Pro Arg Leu His Glu Gly Ala Asp Gly Tyr 1145 1150 1155 Glu Gly Tyr Leu Leu Thr Gly Thr Thr Ala Ser Val Ala Ser Gly 1160 1165 1170 Arg Ile Ala Tyr Thr Leu Gly Thr Arg Gly Pro Ala Leu Thr Val 1175 1180 1185 Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Leu Ala Val 1190 1195 1200 Gln Ala Leu Arg Arg Gly Glu Cys Gly Leu Ala Leu Ala Gly Gly 1205 1210 1215 Ala Thr Val Met Ser Gly Pro Gly Met Phe Val Glu Phe Ser Arg 1220 1225 1230 Gln Arg Gly Leu Ala Pro Asp Gly Arg Cys Met Pro Phe Ser Ala 1235 1240 1245 Asp Ala Asp Gly Thr Ala Trp Ser Glu Gly Val Ala Val Leu Ala 1250 1255 1260 Leu Glu Arg Leu Ser Asp Ala Arg Arg Ala Gly His Arg Val Leu 1265 1270 1275 Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn 1280 1285 1290 Gly Leu Thr Ala Pro Asn Gly Ser Ala Gln Glu Gly Val Ile Arg 1295 1300 1305 Ala Ala Leu Ala Asp Ala Gly Leu Ala Pro Gly Asp Val Asp Ala 1310 1315 1320 Val Glu Ala His Gly Thr Gly Thr Ala Leu Gly Asp Pro Ile Glu 1325 1330 1335 Ala Gly Ala Leu Leu Ala Thr Tyr Gly Arg Glu Arg Val Gly Glu 1340 1345 1350 Pro Leu Trp Leu Gly Ser Leu Lys Ser Asn Val Gly His Thr Gln 1355 1360 1365 Ala Ala Ala Gly Ala Ala Gly Val Ile Lys Met Leu Leu Ala Met 1370 1375 1380 Arg His Gly Thr Leu Pro Arg Thr Leu His Ala Asp Arg Pro Ser 1385 1390 1395 Thr His Val Asp Trp Ser Ser Gly Thr Val Glu Leu Leu Ala Glu 1400 1405 1410 Ala Arg Arg Trp Pro Glu Arg Ala Gly Arg Pro Arg Arg Ala Ala 1415 1420 1425 Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Leu Val Ile 1430 1435 1440 Glu Glu Ala Pro Ala Glu Thr Pro Thr Glu Pro Pro Thr Val Thr 1445 1450 1455 Ala Pro Thr Ala Glu Leu Ala Pro Thr Leu Ala Trp Pro Val Ser 1460 1465 1470 Ala Arg Ser Glu Glu Ala Leu Arg Ala Gln Ala Ala Arg Leu Arg 1475 1480 1485 Glu His Val Glu Arg Val Gly Ala Asp Pro Val Asp Val Ala His 1490 1495 1500 Ser Leu Ala Val Thr Arg Glu Ser Phe Gly Glu Arg Ala Val Val 1505 1510 1515 Val Gly Gly Asp Arg Ala Glu Leu Met Ala Gly Leu Asp Ala Leu 1520 1525 1530 Ala Ala Gly His Thr Arg Pro Lys Thr Val Arg Gly Thr Ala Val 1535 1540 1545 Ser Gly Gly Thr Ala Val Leu Phe Thr Gly Gln Gly Ala Gln Trp 1550 1555 1560 Val Gly Met Gly Arg Glu Leu Tyr Gly Ala Gly Gly Val Phe Ala 1565 1570 1575 Gly Val Leu Asp Glu Val Leu Gly Val Val Gly Glu Val Gly Gly 1580 1585 1590 Arg Ser Leu Arg Glu Val Met Phe Ala Glu Ala Gly Ser Val Asp 1595 1600 1605 Ala Gly Leu Leu Gly Cys Thr Glu Phe Ala Gln Pro Ala Leu Phe 1610 1615 1620 Ala Leu Glu Val Ala Leu Phe Arg Ala Leu Glu Ala Arg Gly Val 1625 1630 1635 Gly Val Ser Val Val Leu Gly His Ser Val Gly Glu Val Ala Ala 1640 1645 1650 Ala Tyr Val Ala Gly Val Phe Ser Leu Ala Asp Ala Val Arg Leu 1655 1660 1665 Val Val Ala Arg Gly Arg Leu Met Gly Ala Leu Pro Val Gly Gly 1670 1675 1680 Ala Met Val Ser Val Gly Ala Ser Glu Ala Glu Leu Ala Gly Leu 1685 1690 1695 Val Ala Gly Leu Gly Gly Arg Val Ser Val Ala Ala Val Asn Gly 1700 1705 1710 Pro Ala Ser Val Val Leu Ser Gly Glu Ala Gly Val Leu Asp Gly 1715 1720 1725 Val Val Ala Gly Leu Val Gly Arg Gly Val Glu Cys Arg Trp Leu 1730 1735 1740 Glu Val Ser His Ala Phe His Ser Val Leu Met Asp Pro Met Leu 1745 1750 1755 Glu Glu Phe Arg Arg Val Ala Ala Ser Val Glu Phe His Arg Pro 1760 1765 1770 Arg Ser Gly Val Ala Val Val Ser Ser Val Thr Gly Ala Val Ala 1775 1780 1785 Gly Leu Asp Glu Leu Gly Asp Pro Glu Tyr Trp Val Arg His Val 1790 1795 1800 Arg Glu Ala Val Arg Phe Ala Asp Gly Val Gly Ala Ala Arg Asp 1805 1810 1815 Val Gly Val Asp Thr Phe Val Glu Val Gly Pro His Ala Val Leu 1820 1825 1830 Thr Val Met Ala Gly Gln Cys Leu Asp Gly Asp Glu Gly Asp Leu 1835 1840 1845 Ala Phe Val Pro Val Leu Arg Arg Asp Arg Pro Glu Leu Glu Thr 1850 1855 1860 Phe Thr Thr Ala Leu Ala Thr Leu Tyr Ala Arg Gly Ala Gln Ile 1865 1870 1875 Asp Trp Asp Ala Pro Asn Arg Lys Arg Asp Ala Arg Arg Ile Asp 1880 1885 1890 Leu Pro Thr Tyr Pro Phe Gln Arg Ala Arg Phe Trp Leu Asp Pro 1895 1900 1905 Ala Pro Ala Ala Val Pro Thr Ala Met Ala Ala Gly Ser Ser Glu 1910 1915 1920 Asp Val Pro Thr Ala Ala Gln Gly Val Thr Ser Ala Thr Ala Gly 1925 1930 1935 Leu Arg Tyr Arg Val Thr Trp Gln Pro Ala Ala Val Gly Cys Gly 1940 1945 1950 Val Pro Arg Pro Ala Gly Arg Met Leu Leu Leu Ala Ser Asp Asp 1955 1960 1965 Asp Thr Thr Asp Ser Gly Leu Ala Thr Ala Ile Ala Arg Glu Leu 1970 1975 1980 Ala Val Arg Gly Thr Glu Val His Thr Ala Val Val Pro Val Gly 1985 1990 1995 Thr Gly Arg Glu Ala Ala Ala Asp Leu Leu Arg Ala Ala Gly Asp 2000 2005 2010 Gly Ala Ala Arg Ser Thr His Val Leu Trp Leu Ala Pro Ala Glu 2015 2020 2025 Pro Asp Thr Ala Asp Ala Val Ala Leu Ile Gln Ala Leu Gly Glu 2030 2035 2040 Ala Gly Pro Asp Ala Pro Leu Trp Ile Thr Thr Arg Asp Ala Val 2045 2050 2055 Ala Ala Gln Pro Gly Glu Ala Pro Ser Val Ala Gly Ala Gln Leu 2060 2065 2070 Trp Gly Leu Gly Gln Val Ala Ala Leu Glu Leu Ala Gln Arg Trp 2075 2080 2085 Gly Gly Leu Ala Asp Leu Pro Gly Glu Pro Ser Pro Ala Ala Leu 2090 2095 2100 Arg Ala Phe Val Gly Thr Leu Leu Ala Glu Gly Glu Asp Asn Gln 2105 2110 2115 Phe Ala Val Arg Pro Ser Gly Val His Val Arg Arg Val Val Pro 2120 2125 2130 Val Pro Val Arg Ala Ala Thr Thr Ala Ala Ala Arg Asp Ala Gln 2135 2140 2145 Gly Asp Thr Pro Asp Gly Val Val Pro Gly Asn Arg Arg Ser Ser 2150 2155 2160 Gly Thr Val Leu Ile Thr Gly Gly Thr Gly Ala Leu Gly Ala Gln 2165 2170 2175 Val Ala Arg Arg Leu Ala Arg Ala Gly Ala Pro His Leu Leu Leu 2180 2185 2190 Val Gly Arg Arg Gly Ala Ala Gly Pro Gly Ala Gly Glu Leu Val 2195 2200 2205 Glu Glu Leu Thr Ala Leu Gly Thr Glu Val Thr Val Ala Ala Cys 2210 2215 2220 Asp Val Ala Asp Arg Asp Ala Leu Ala Ala Leu Leu Ala Gly Ile 2225 2230 2235 Pro Glu Asp Arg Pro Leu Ala Ala Val Leu His Ala Ala Gly Val 2240 2245 2250 Leu Asp Asp Gly Val Leu Asp Ser Leu Thr Ser Asp Arg Ile Asp 2255 2260 2265 Ala Val Leu Arg Ala Lys Val Thr Ala Ala Arg His Leu Asp Glu 2270 2275 2280 Leu Thr Ala Asp Leu Pro Leu Asp Ala Phe Val Leu Phe Ser Ser 2285 2290 2295 Ile Val Gly Val Trp Gly Asn Gly Gly Gln Ala Ala Tyr Ala Ala 2300 2305 2310 Ala Asn Ala Ala Leu Asp Ala Leu Ala His Arg Arg Arg Ala Arg 2315 2320 2325 Gly Gly Arg Ala Thr Ser Ile Ala Trp Gly Pro Trp Ala Gly Ala 2330 2335 2340 Gly Met Ala Ser Gly Thr Ala Thr Lys Ser Phe Glu Arg Asp Gly 2345 2350 2355 Val Ala Ala Leu Asp Pro Glu His Ala Leu Asp Val Leu Asp Asp 2360 2365 2370 Ala Val Gly Ala Gly Gly Thr Ser Ala Ala Ala Gly Ala Ser Ala 2375 2380 2385 Ala Val Ala Thr Ser Leu Ile Val Ala Asp Val Asp Trp Glu Thr 2390 2395 2400 Phe Val Gly Arg Ser Val Thr Arg Arg Thr Trp Ala Leu Phe Asp 2405 2410 2415 Gly Val Pro Ala Ala Arg Ser Ala Arg Ser Ala Arg Ala Ala Gln 2420 2425 2430 Gly Arg Ala Thr Leu Pro Arg Gly Thr Arg Pro Gly His Gly Gly 2435 2440 2445 Pro Gly Gly Ser Gly Ala Gly Ala Asp Glu Gly Arg Pro Trp Leu 2450 2455 2460 Ser Val Gly Pro Ser Ser Thr Glu Arg Arg Arg Ala Leu Leu Asp 2465 2470 2475 Leu Val Cys Ser Glu Ala Ala Glu Ile Leu Arg His Ala Ser Ala 2480 2485 2490 Asp Ala Val Asp Pro Glu Ile Ala Phe Arg Ser Ala Gly Phe Asp 2495 2500 2505 Ser Leu Thr Val Leu Glu Leu Arg Asn Arg Leu Thr Ala Ala Thr 2510 2515 2520 Gly Leu Asn Leu Pro Ser Thr Leu Leu Phe Asp His Pro Asn Pro 2525 2530 2535 Thr Ser Leu Ala Ala His Leu His Asp Glu Leu Phe Gly Thr Asp 2540 2545 2550 Ser Glu Ala Glu Pro Val Ala Asp Thr Arg Ala Arg Ala Thr Ala 2555 2560 2565 Asp Glu Arg Glu Pro Ile Ala Ile Val Gly Met Ala Cys Arg Tyr 2570 2575 2580 Pro Gly Gly Val Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Ala 2585 2590 2595 Glu Asp Gly His Thr Leu Ser Pro Phe Pro Val Asp Arg Gly Trp 2600 2605 2610 Asp Val Glu Gly Leu Tyr Asp Pro Asp Pro Glu Ala Val Gly Arg 2615 2620 2625 Ser Tyr Val Arg Glu Gly Gly Phe Leu His Gly Ala Ala Glu Phe 2630 2635 2640 Asp Ala Glu Phe Phe Gly Ile Ser Pro Arg Glu Ala Ala Ala Met 2645 2650 2655 Asp Pro Gln Gln Arg Leu Leu Leu Glu Thr Ser Trp Glu Ala Leu 2660 2665 2670 Glu Arg Ala Gly Ile Val Pro Asp Ala Leu Arg Gly Thr Arg Thr 2675 2680 2685 Gly Val Phe Thr Gly Ile Ser Gln Gln Asp Tyr Ala Ser Gln Leu 2690 2695 2700 Gly Asp Ala Ala Glu Thr Tyr Gly Gly His Val Leu Thr Gly Thr 2705 2710 2715 Leu Gly Ser Val Ile Ser Gly Arg Val Ala Tyr Val Leu Gly Leu 2720 2725 2730 Glu Gly Pro Ala Leu Thr Val Asp Thr Ala Cys Ser Ser Ser Leu 2735 2740 2745 Val Ala Leu His Leu Ala Val Gln Ser Leu Arg Arg Gly Glu Cys 2750 2755 2760 Asp Met Ala Leu Ala Gly Gly Val Thr Val Met Ala Thr Pro Thr 2765 2770 2775 Val Phe Val Glu Phe Ser Arg Gln Arg Gly Leu Ala Ser Asp Gly 2780 2785 2790 Arg Cys Lys Ala Phe Ala Glu Gly Ala Asp Gly Thr Val Trp Ala 2795 2800 2805 Glu Gly Val Gly Val Leu Leu Val Glu Arg Leu Ser Asp Ala Arg 2810 2815 2820 Arg Tyr Gly His Arg Val Leu Ala Val Val Arg Gly Ser Ala Val 2825 2830 2835 Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Ser Gly Ala 2840 2845 2850 Ala Gln Arg Arg Val Ile Arg Glu Ala Leu Ala Asp Ala Gly Leu 2855 2860 2865 Ala Pro Gly Asp Val Asp Ala Val Glu Ala His Gly Thr Gly Thr 2870 2875 2880 Ala Leu Gly Asp Pro Ile Glu Ala Gly Ala Leu Leu Ala Thr Tyr 2885 2890 2895 Gly Arg Glu Arg Val Gly Asp Pro Leu Trp Leu Gly Ser Leu Lys 2900 2905 2910 Ser Asn Ile Gly His Ala Gln Ala Ala Ala Gly Val Gly Gly Val 2915 2920 2925 Ile Lys Met Val Glu Ala Met Arg His Ser Ser Leu Pro Arg Thr 2930 2935 2940 Leu His Val Asp Ala Pro Ser Ser Arg Val Glu Trp Gly Ser Gly 2945 2950 2955 Ala Val Glu Leu Leu Thr Glu Ala Arg Ser Trp Pro Arg Arg Ala 2960 2965 2970 Gly Arg Val Arg Arg Ala Ala Val Ser Ala Phe Gly Val Ser Gly 2975 2980 2985 Thr Asn Ala His Val Val Ile Glu Glu Pro Ser Val Glu Glu Ser 2990 2995 3000 Ala Glu Ala Glu Ala Val Val Thr Ala Ala Ala Glu Ser Ser Ser 3005 3010 3015 Val Leu Ala Trp Pro Val Ser Ala Arg Ser Glu Glu Ala Leu Arg 3020 3025 3030 Gly Gln Ala Val Arg Leu Arg Glu His Val Glu Arg Val Gly Ala 3035 3040 3045 Asp Pro Val Asp Val Ala His Ser Leu Val Val Ser Arg Ala Ser 3050 3055 3060 Phe Gly Glu Arg Ala Val Val Val Gly Arg Glu Arg Gly Glu Leu 3065 3070 3075 Leu Ala Gly Leu Asp Ala Val Ala Ala Gly Val Val Ala Ala Gly 3080 3085 3090 Gly Ala Ala Ser Gly Val Val Arg Gly Ser Ala Val Arg Gly Arg 3095 3100 3105 Arg Val Gly Val Leu Phe Thr Gly Gln Gly Ala Gln Trp Val Gly 3110 3115 3120 Met Gly Arg Glu Leu Tyr Gly Ala Gly Gly Val Phe Ala Gly Val 3125 3130 3135 Leu Asp Glu Val Leu Gly Val Val Gly Glu Val Gly Gly Arg Ser 3140 3145 3150 Leu Arg Glu Val Met Phe Ala Glu Ala Gly Ser Val Asp Ala Gly 3155 3160 3165 Leu Leu Gly Cys Thr Glu Phe Ala Gln Pro Ala Leu Phe Ala Leu 3170 3175 3180 Glu Val Ala Leu Phe Arg Ala Leu Glu Ala Arg Gly Val Gly Val 3185 3190 3195 Ser Val Val Leu Gly His Ser Val Gly Glu Val Ala Ala Ala Tyr 3200 3205 3210 Val Ala Gly Val Phe Ser Leu Ala Asp Ala Val Arg Leu Val Val 3215 3220 3225 Ala Arg Gly Arg Leu Met Gly Ala Leu Pro Val Gly Gly Ala Met 3230 3235 3240 Val Ser Val Gly Ala Ser Glu Ala Glu Leu Ala Gly Leu Val Ala 3245 3250 3255 Gly Leu Gly Gly Arg Val Ser Val Ala Ala Val Asn Gly Pro Ala 3260 3265 3270 Ser Val Val Leu Ser Gly Glu Ala Gly Val Leu Asp Gly Val Val 3275 3280 3285 Ala Gly Leu Val Gly Arg Gly Val Glu Cys Arg Trp Leu Glu Val 3290 3295 3300 Ser His Ala Phe His Ser Val Leu Met Asp Pro Met Leu Glu Glu 3305 3310 3315 Phe Arg Arg Val Ala Ala Ser Val Glu Phe His Arg Pro Arg Ser 3320 3325 3330 Gly Val Ala Val Val Ser Ser Val Thr Gly Ala Val Ala Gly Leu 3335 3340 3345 Asp Glu Leu Gly Asp Pro Glu Tyr Trp Val Arg His Val Arg Glu 3350 3355 3360 Ala Val Arg Phe Ala Asp Gly Val Gly Ala Ala Arg Asp Val Gly 3365 3370 3375 Val Asp Thr Phe Val Glu Val Gly Pro His Ala Val Leu Thr Val 3380 3385 3390 Met Ala Gly Gln Cys Leu Asp Gly Asp Glu Gly Asp Leu Ala Phe 3395 3400 3405 Val Pro Val Leu Arg Arg Asp Arg Pro Glu Leu Glu Thr Phe Thr 3410 3415 3420 Thr Ala Leu Ala Thr Leu Tyr Thr Arg Asp Ala Glu Leu Asp Val 3425 3430 3435 Ala Ala Leu His Ser Gly Phe Gly Gly Arg Arg Val Asp Leu Pro 3440 3445 3450 Thr Tyr Pro Phe Gln Arg Arg Gly Tyr Trp Ala Thr Gly Ser Val 3455 3460 3465 Ser Gly Ser Thr Gly Ser Ser Ala Ala Ala Arg Phe Gly Leu Glu 3470 3475 3480 Trp Lys Asp His Pro Phe Leu Ser Gly Ala Thr Pro Ile Val Gly 3485 3490 3495 Ser Gly Ala Leu Leu Leu Thr Gly Arg Val Ala Leu Ser Thr His 3500 3505 3510 Pro Trp Leu Ala Asp His Ala Ile Ser Gly Thr Val Leu Leu Pro 3515 3520 3525 Gly Thr Ala Ile Ala Asp Leu Leu Leu Arg Ala Ala Glu Glu Val 3530 3535 3540 Gly Ala Gly Gly Val Glu Glu Leu Thr Leu His Ala Pro Leu Leu 3545 3550 3555 Leu Pro Glu Gln Gly Gly Leu Arg Leu Gln Val Leu Val Glu Ala 3560 3565 3570 Ala Asp Gly Gln Gly Arg Arg Ala Val Ala Leu Ala Ala Arg Pro 3575 3580 3585 Glu Thr Pro Gly Trp Asp Gly Glu Glu Pro Glu Trp Thr Lys His 3590 3595 3600 Ala Glu Gly Val Leu Ala Pro Ala Glu Pro Ala Val Pro Asp Thr 3605 3610 3615 Ala Trp Ala Ala Gly Ala Trp Pro Pro Pro Gly Ala Glu Pro Val 3620 3625 3630 Asp Val Gly Glu Leu Tyr Glu Gly Phe Ala Ala Asp Gly Tyr Asp 3635 3640 3645 Tyr Gly Pro Ala Phe Ser Gly Leu Ser Gly Ala Trp Arg Leu Gly 3650 3655 3660 Asn Glu Leu Phe Ala Glu Val Arg Leu Ser Ala Thr Gly Thr Ala 3665 3670 3675 Gly Asp Gly Phe Gly Ile His Pro Ala Leu Phe Asp Ala Ala Leu 3680 3685 3690 His Pro Trp Arg Ala Gly Gly Leu Leu Pro Asp Thr Gly Gly Thr 3695 3700 3705 Thr Leu Ala Pro Phe Ser Trp Gln Gly Ile Ala Leu His Ala Thr 3710 3715 3720 Gly Ala Glu Thr Leu Arg Val Arg Leu Ala Pro Ala Gly Ser Gly 3725 3730 3735 Ala Glu Ser Ala Phe Ser Val Arg Ala Ala Asp Pro Ala Gly Ala 3740 3745 3750 Pro Val Leu Thr Leu Asp Ala Leu Leu Leu Arg Pro Val Ala Leu 3755 3760 3765 Gly Thr Ala Gly Ala Pro Glu Pro Leu Tyr Arg Val Asp Trp Gln 3770 3775 3780 Pro Val Pro Gln Arg Ser Asp Thr Pro Gly Ala His Gly Trp Thr 3785 3790 3795 Val Leu Gly Pro Ala Ala Gly Glu Thr Ala Ala Glu Gln Ala Ala 3800 3805 3810 Thr Glu Glu Cys Ala Thr Leu Arg Ala Leu Pro Gly Ala Glu Pro 3815 3820 3825 Ala Ala His Ala Asp Leu Ala Ala Leu Arg Thr Ala Leu Thr Ala 3830 3835 3840 Gly Thr Pro Val Pro Gly Leu Val Val Val Pro Ala Thr Asp Ile 3845 3850 3855 Arg Pro Ala Glu Ser Ser Ala Gly Ala Gly Ala Gly Val Asp Ala 3860 3865 3870 Gly Ala Asp Ala Arg Val Arg Arg Gly Lys Ala His Val Arg Thr 3875 3880 3885 Ala Thr Ala His Ala Arg Thr Gly Thr Asp Trp Gly Asp Asp Pro 3890 3895 3900 Val Arg Val Ala Leu Gly Arg Gly Leu Ala Leu Val Arg Glu Trp 3905 3910 3915 Thr Glu Asp Glu Arg Leu Ala Asp Ser Arg Leu Val Val Leu Thr 3920 3925 3930 Arg Gly Ala Val Glu Ala Gly Ser Gly Glu Val Pro Asp Leu Ala 3935 3940 3945 Gly Ala Ala Leu Trp Gly Leu Leu Arg Ser Ala Gln Ser Glu Tyr 3950 3955 3960 Pro Asp Arg Phe Thr Leu Val Asp Val Asp Asp Ser Pro Glu Ser 3965 3970 3975 Arg Ala Ala Leu Pro Arg Ala Leu Glu Ser Gly Glu Pro Gln Leu 3980 3985 3990 Ala Leu Arg Ala Gly Ala Leu Leu Ala Pro Ala Leu Val Pro Ile 3995 4000 4005 Thr Thr Pro Ala Thr Ala Ala Thr Pro Ala Thr Ala Val Asp Ser 4010 4015 4020 Ala Ala Ala Ala Val Ala Ala Gln Ser Val Ala Pro Glu Ala Ala 4025 4030 4035 Gly Pro Ala Glu Arg Gly Gly Ala Ala Thr Gly Gly Pro Ala Ser 4040 4045 4050 Asp Gly Ala Phe Asp Pro Asp Gly Ser Ala Val Asp Ala Val Phe 4055 4060 4065 Asp Pro Ala Gly Thr Val Leu Ile Thr Gly Cys Thr Gly Ala Leu 4070 4075 4080 Gly Arg Arg Val Ala Pro His Leu Ala Arg Arg His Gly Val Arg 4085 4090 4095 His Met Leu Leu Val Ser Arg Arg Gly Pro Asp Ala Pro Glu Ala 4100 4105 4110 Ala Leu Leu Glu Arg Glu Leu Val Gly Leu Gly Val Thr Ala Thr 4115 4120 4125 Phe Leu Ala Cys Asp Leu Ala Asp Pro Ala Ala Val Arg Lys Ala 4130 4135 4140 Val Val Ala Val Ser Pro Glu His Pro Leu Thr Gly Val Val His 4145 4150 4155 Thr Ala Gly Val Leu Asp Asp Gly Ala Leu Thr Gly Leu Thr Gln 4160 4165 4170 Glu Arg Leu Asp Thr Val Leu Arg Ser Lys Ala Asp Ala Val Arg 4175 4180 4185 Asn Leu His Glu Ala Thr Leu Asp Arg Pro Leu Arg Ala Phe Val 4190 4195 4200 Leu Phe Ser Ala Ala Ala Gly Leu Leu Gly Arg Pro Gly Gln Gly 4205 4210 4215 Ser Tyr Ala Ala Ala Asn Ala Val Leu Asp Ala Leu Ala Gly Ala 4220 4225 4230 Arg Arg Ala Ala Gly Leu Pro Ala Val Ser Leu Ala Trp Gly Leu 4235 4240 4245 Trp Asp Glu Arg Ala Gly Met Ala Gly Gly Leu Asp Asp Val Ala 4250 4255 4260 Leu His Arg Leu Arg Arg Glu Gly Ile Ala Ala Met Pro Pro Glu 4265 4270 4275 Gln Gly Leu Gly Leu Leu Asp Gln Ala Leu Thr Ala His Arg Asp 4280 4285 4290 Gly Pro Ala Val Leu Val Pro Leu Leu Leu Asp Gly Ala Ala Leu 4295 4300 4305 Arg Arg Thr Ala Lys Glu Arg Gly Ala Ala Ala Val Pro Pro Leu 4310 4315 4320 Leu Arg Gly Leu Leu Pro Ala Ala Leu Arg His Ser Ser Thr Gly 4325 4330 4335 Thr Pro Ala Ala Ala Asp Arg His Gly Lys Gly Ala Glu Ser Gly 340 4345 4350 Thr Gly Arg Ile Ala Arg Ile Val Ala Leu Asp Ala Ala Glu Arg 4355 4360 4365 Ser Thr Ala Val Leu Asp Leu Val Thr Glu Gln Val Ala Glu Val 4370 4375 4380 Leu Gly His Ala Ser Ala Ala Glu Ile Glu Pro Glu Arg Pro Phe 4385 4390 4395 Arg Glu Ile Gly Val Asp Ser Leu Ala Ala Val Glu Leu Arg Asn 4400 4405 4410 Arg Leu Ser Arg Leu Val Gly Leu Arg Leu Pro Thr Thr Leu Ala 4415 4420 4425 Phe Asp His Pro Thr Pro Lys Asp Met Ala Glu Trp Ile Asp Gly 4430 4435 4440 Glu Leu Pro Arg Pro Ala Gly Ala Pro Val Val Asp Ala Ala Leu 4445 4450 4455 Glu Gly Ile Gly Glu Leu Ala Arg Ala Val Ala Leu Leu Gly Ser 4460 4465 4470 Asp Asp Ala Arg Arg Val Glu Val Arg Gln Arg Leu Val Gly Leu 4475 4480 4485 Leu Thr Ala Leu Asp Thr Pro Gly Arg Gly Val Val Gly Pro Gln 4490 4495 4500 Gly Arg Thr Ala Pro Ala Ala Pro Ala Ala Ala Asp Gly Ala Gly 4505 4510 4515 Ala Thr Val Thr Asp Arg Leu Asp Glu Ala Thr Asp Asp Glu Ile 4520 4525 4530 Phe Ala Phe Leu Asp Glu Gln Leu 4535 <210> 17 <211> 403 <212> Pro <213> Streptomyces spiramyceticus WSJ-1£© <400> 1 Met Gly Glu Ala Val Ser Gly Pro Met Glu Leu Ser Lys Asp Ala 5 10 15 Asp Ala Arg Gly Leu Leu Asp Trp Phe Ala Phe Asn Arg Thr Arg 20 25 30 His Pro Val Phe Trp Asp Glu Gly Arg Gln Ala Trp Gln Val Phe 35 40 45 Gly Tyr Asp Asp Tyr Val Thr Val Ser Asn Asn Pro Gln Phe Phe 50 55 60 Ser Ser Asp Phe Asn Met Val Met Pro Thr Pro Pro Glu Leu Glu 65 70 75 Met Ile Ile Gly Pro Gly Thr Ile Gly Ala Leu Asp Pro Pro Ala 80 85 90 His Gly Pro Met Arg Lys Leu Val Ser Gln Ala Phe Thr Pro Arg 95 100 105 Arg Ile Ala Arg Leu Glu Pro Arg Val Arg Ala Ile Thr Glu Glu 110 115 120 Leu Leu Asp Lys Val Arg Glu Gln Asn Val Ile Asp Ala Val Gly 125 130 135 Asp Leu Ser Tyr Ala Leu Pro Val Ile Val Ile Ala Glu Leu Leu 140 145 150 Gly Val Pro Thr Gly Asp Arg Asp Leu Phe Arg Glu Trp Val Asp 155 160 165 Thr Leu Leu Thr Asn Glu Gly Leu Glu Tyr Pro Asn Leu Pro Asp 170 175 180 Asn Phe Thr Glu Thr Ile Ala Pro Ala Leu Lys Glu Met Thr Asp 185 190 195 Tyr Leu Leu Glu Gln Ile His Ala Lys Arg Glu Ala Pro Ala Asp 200 205 210 Asp Leu Ile Ser Gly Leu Val Gln Ala Glu Gln Asp Gly Arg Arg 215 220 225 Leu Thr Asp Val Glu Ile Val Asn Ile Val Ala Leu Leu Leu Thr 230 235 240 Ala Gly His Val Ser Ser Ser Thr Leu Leu Ser Asn Leu Phe Leu 245 250 255 Val Leu Glu Glu Asn Pro Gln Ala Leu Glu Asp Leu Arg Ala Asp 260 265 270 Arg Thr Leu Val Pro Gly Ala Ile Glu Glu Thr Leu Arg Tyr Arg 275 280 285 Ser Pro Phe Asn Asn Ile Phe Arg Phe Val Lys Gln Asp Thr Thr 290 295 300 Ile Leu Gly Pro Leu Met Glu Lys Gly Gln Met Val Ile Ala Trp 305 310 315 Ser Gln Ser Ala Asn Arg Asp Pro Arg His Phe Pro Asp Pro Asp 320 325 330 Thr Phe Asp Ile Arg Arg Ser Asp Gly Thr Arg His Met Ala Phe 335 340 345 Gly His Gly Ile His His Cys Leu Gly Ala Ala Leu Ala Arg Leu 350 355 360 Glu Gly Lys Val Met Leu Glu Leu Leu Leu Glu Arg Val Asp Gly 365 370 375 Phe Arg Ile Asp His Glu Asn Thr Leu Phe Tyr Glu Ala Asp Gln 380 385 390 Leu Thr Pro Lys Tyr Leu Pro Val Arg Val Asp Trp Asn 395 400 <210> 18 <211> 116 <212> Pro <213> Streptomyces spiramyceticus WSJ-1£© <400> 1 Met Val Glu Ser Gly Val Thr Val Asp Phe Pro Val Gln Arg Val 5 10 15 Tyr Tyr Met His Gly Gln Thr Gln Ser Ser Pro Pro Arg Gly Leu 20 25 30 His Ala His Arg Thr Leu Glu Gln Leu Val Ile Ala Val His Gly 35 40 45 Ala Phe Ser Ile Thr Leu Asp Asp Gly Phe Gln His Ala Thr Tyr 50 55 60 Arg Leu Asp Glu Pro Gly Ala Gly Leu Cys Ile Gly Pro Met Val 65 70 75 Trp Arg Val Leu Lys Asp Phe Ala Pro Asp Thr Val Ala Leu Val 80 85 90 Leu Ala Ser Gln His Tyr Glu Glu Ser Asp Tyr Tyr Arg Asp Tyr 95 100 105 Asp Thr Phe Leu His Asp Ala Arg Ser Leu Thr 110 115 <210> 19 <211> 399 <212> Pro <213> Streptomyces spiramyceticus WSJ-1£© <400> 1 Met Thr Ile Pro Phe Leu Asp Ala Gly Ala Gly Tyr Arg Glu Leu 5 10 15 Arg Ala Asp Ile Asp Ala Ala Leu Gln Arg Val Ser Ala Ser Gly 20 25 30 Arg Tyr Leu Leu Gly Ala Glu Leu Glu Gly Phe Glu Glu Glu Phe 35 40 45 Ala Ala Tyr Cys Asp Asn Gly His Cys Val Ala Val Gly Ser Gly 50 55 60 Cys Asp Ala Leu Glu Leu Ser Leu Arg Ala Leu Asp Ile Gly Pro 65 70 75 Gly Asp Glu Val Val Val Pro Ala His Thr Phe Ile Gly Thr Trp 80 85 90 Leu Ala Val Ser Ala Thr Gly Ala Gln Pro Val Ala Val Asp Pro 95 100 105 Thr Pro Asp Gly Leu Ser Leu Asp Pro Ala Leu Val Glu Ala Ala 110 115 120 Val Thr Pro Arg Thr Lys Ala Leu Met Pro Val His Leu His Gly 125 130 135 His Pro Ala Asp Leu Asp Pro Leu Leu Ala Val Ala Glu Arg His 140 145 150 Gly Leu Ala Val Val Glu Asp Ala Ala Gln Ala His Gly Ala Arg 155 160 165 Tyr Arg Gly Arg Arg Ile Gly Ser Gly His Val Val Ala Phe Ser 170 175 180 Phe Tyr Pro Gly Lys Asn Leu Gly Ala Met Gly Asp Gly Gly Ala 185 190 195 Val Val Thr Arg Asp Ala Gly Val Ala Asp Arg Ile Arg Leu Leu 200 205 210 Arg Asn Cys Gly Ser Arg Glu Lys Tyr Arg His Glu Val Arg Ala 215 220 225 Thr Asn Ser Arg Leu Asp Glu Leu Gln Ala Ala Val Leu Arg Ala 230 235 240 Lys Leu Pro Arg Leu Asp Ala Trp Asn Ala Arg Arg Ala Arg Thr 245 250 255 Ala Glu Arg Tyr Thr Arg Ala Leu Gly Ser Leu Pro Gln Ile Ala 260 265 270 Val Pro Val Thr Ala Arg Trp Ala Asp Pro Ala Trp His Leu Tyr 275 280 285 Val Ile Arg Cys Ala Glu Arg Asp Glu Leu Arg Arg Arg Leu Glu 290 295 300 Arg Ala Gly Val Gln Thr Leu Ile His Tyr Pro Val Pro Pro His 305 310 315 Arg Ser Pro Ala Tyr Ala Asp Ala Pro Ala Gly Ala Pro Ala Gly 320 325 330 Ala His Pro Arg Ser Glu Arg Leu Ala Ala Gln Ser Leu Ser Leu 335 340 345 Pro Leu Gly Pro His Leu Gly Asp Asp Glu Ser Arg Ala Val Val 350 355 360 Ala Ala Val Arg Ala Ala Ala Ala Gly Leu Ala Ala Tyr Pro Thr 365 370 375 Pro Asp Gly Thr Pro Arg Thr Pro Arg Thr Thr Pro Asp Gly Gln 380 385 390 Ar gPhe Pro Leu Ala Thr Glu Lys Arg 395 <210> 20 <211> 302 <212> Pro <213> Streptomyces spiramyceticus WSJ-1£© <400> 1 Met Thr Glu Val Met Ser Gly Arg Ser Gly Met Lys Gly Ile Ile 5 10 15 Leu Ala Gly Gly Gly Gly Thr Arg Leu Arg Pro Leu Thr Gly Thr 20 25 30 Leu Ser Lys Gln Leu Leu Pro Val Tyr Asp Lys Pro Met Ile Tyr 35 40 45 Tyr Pro Leu Ser Val Leu Met Leu Gly Gly Ile Arg Glu Ile Leu 50 55 60 Val Ile Ser Ser Thr Gln His Ile Glu Leu Phe Gln Gln Leu Leu 65 70 75 Gly Asp Gly Ser Arg Leu Gly Leu Asp Ile Thr Tyr Ala Glu Gln 80 85 90 Pro Glu Pro Gln Gly Ile Ala Gln Ala Leu Thr Ile Gly Thr Asp 95 100 105 His Ile Gly Asp Ser Pro Val Ala Leu Ile Leu Gly Asp Asn Ile 110 115 120 Phe His Gly Pro Gly Phe Ser Ser Val Leu Arg Gly Ser Ile Arg 125 130 135 His Leu Asp Gly Cys Val Leu Phe Gly Tyr Pro Val Ser Asp Pro 140 145 150 Gln Arg Tyr Gly Val Gly Glu Ile Asp Asp Gln Gly Met Leu Leu 155 160 165 Ser Leu Glu Glu Lys Pro Ala Arg Pro Arg Ser Asn Leu Ala Val 170 175 180 Thr Gly Leu Tyr Leu Tyr Asp Asn Asp Val Val Asp Ile Ala Lys 185 190 195 Asn Ile Arg Pro Ser Ala Arg Gly Glu Leu Glu Ile Thr Asp Val 200 205 210 Asn Gln Val Tyr Leu Glu Gln Lys Arg Ala Arg Leu Ile Glu Leu 215 220 225 Gly His Gly Phe Ala Trp Leu Asp Met Gly Thr His Asp Ser Leu 230 235 240 Leu Gln Gly Gly Gln Tyr Val Gln Leu Leu Glu Gln Arg Gln Gly 245 250 255 Val Arg Ile Ala Cys Ile Glu Glu Ile Ala Leu Arg Met Gly Phe 260 265 270 Ile Asp Ala Asp Thr Leu Tyr Trp Leu Gly Arg Glu Leu Gly Thr 275 280 285 Ser Gly Tyr Gly Ala Tyr Leu Met Glu Val Ala Thr His Ala Gly 290 295 300 Ala Ala <210> 21 <211> 345 <212> Pro <213> Streptomyces spiramyceticus WSJ-1£© <400> 1 Met Gln Ala Pro His Glu Ser Pro His Arg Pro Thr Arg Phe Ala 5 10 15 Asp Gly Arg Gln Pro Ala Arg Ile Leu Val Thr Gly Gly Ala Gly 20 25 30 Phe Ile Gly Ser Arg Phe Val Asn Ala Leu Leu Asp Gly Ser Leu 35 40 45 Pro Glu Phe Gly Lys Pro Glu Val Arg Val Leu Asp Ala Leu Thr 50 55 60 Tyr Ala Gly Asn Leu Ala Asn Leu Ala Pro Val Gly Asp Cys Pro 65 70 75 Arg Leu Arg Ile Phe Gln Gly Asp Ile Cys Asp Arg Ser Ala Val 80 85 90 Ala Gln Ala Met Ala Gly Val Asp Leu Val Val His Phe Ala Ala 95 100 105 Glu Ser His Val Asp Arg Ser Ile Asp Asp Ala Asp Ala Phe Val 110 115 120 Arg Thr Asn Val Leu Gly Thr Gln Val Leu Leu Gln Glu Ala Leu 125 130 135 Ala Ile Arg Pro Gly Leu Phe Val His Val Ser Thr Asp Glu Val 140 145 150 Tyr Gly Ser Ile Pro Val Gly Ser Trp Pro Glu Asp His Pro Leu 155 160 165 Ser Pro Asn Ser Pro Tyr Ala Ala Ser Lys Ala Ser Ser Asp Leu 170 175 180 Leu Ala Leu Ala Tyr His Arg Thr His Gly Leu Pro Val Cys Val 185 190 195 Thr Arg Cys Ser Asn Asn Tyr Gly Pro Tyr Gln Tyr Pro Glu Lys 200 205 210 Ile Ile Pro Leu Phe Thr Ser Asn Leu Leu Asp Gly Arg Thr Val 215 220 225 Pro Leu Tyr Gly Asp Gly Gly Asn Arg Arg Asp Trp Leu His Val 230 235 240 Asn Asp His Cys Arg Gly Ile Ala Leu Val Ala Arg Gly Gly Arg 245 250 255 Pro Gly Glu Val Tyr Asn Ile Gly Gly Gly Ala Glu Leu Thr Asn 260 265 270 Val Glu Leu Thr Glu Arg Leu Leu Lys Leu Cys Gly Ala Asp Trp 275 280 285 Ser Ala Val Arg Gln Val Pro Asp Arg Lys Gly His Asp Gln Arg 290 295 300 Tyr Ser Val Asp Tyr Thr Lys Ile Ala Thr Glu Leu Gly Tyr Ala 305 310 315 Pro Arg Ile Thr Ile Asp Glu Gly Leu Glu Gln Thr Val Arg Trp 320 325 330 Tyr Arg Glu Asn His Ala Trp Trp Thr Pro Val Lys Arg Gly Arg 335 340 345 <210> 22 <211> 745 <212> Pro <213> Streptomyces spiramyceticus WSJ-1£© <400> 1 Met Val Asp Ala Cys Glu Glu Gly Thr Met Thr Leu Met Ser Ala 5 10 15 Ser Val Asp Pro Arg Asp Leu Trp Leu Arg Arg Tyr Gln Pro Ser 20 25 30 Ala Ser Pro Ala Val Arg Leu Val Cys Phe Pro His Ala Gly Gly 35 40 45 Ser Ala Ser Ser Phe Leu Pro Phe Thr Arg Gln Leu Pro Asp Arg 50 55 60 Ile Glu Val Ser Ala Val Gln Tyr Pro Gly Arg Gln Asp Arg Arg 65 70 75 Ser Glu Pro Leu Ile Asp Thr Ile Glu Gly Leu Ala Lys Pro Leu 80 85 90 Ala Asp Met Leu Glu Thr Arg Ala Gly Pro Pro Val Val Leu Phe 95 100 105 Gly His Ser Met Gly Ala Leu Val Ala Tyr Glu Val Ala Arg Val 110 115 120 Leu Gln Gln Arg Gly Ala Ala Pro Val Arg Leu Val Val Ser Gly 125 130 135 Arg Arg Ala Pro Ala Ser Asp Arg Pro Met Thr Val His Leu Tyr 140 145 150 Asp Asp Asp Arg Leu Val Glu Glu Leu Arg Thr Leu Asp Gly Thr 155 160 165 Asp Ser Gln Val Phe Ala Asp Pro Glu Leu Leu Gln Leu Val Leu 170 175 180 Pro Ala Ile Arg Asn Asp Tyr Arg Ala Val Gly Thr Tyr Thr His 185 190 195 Arg Pro Gly Ala Pro Leu Asp Cys Pro Leu Thr Val Phe Thr Gly 200 205 210 Ala Asp Asp Pro Thr Val Thr Ala Ala Glu Ala Ala Ala Trp His 215 220 225 Glu Val Ala Ala Ala Gly Ala Glu Met Arg Thr Phe Pro Gly Gly 230 235 240 His Phe Phe Pro Tyr Gln Arg Thr Ala Glu Val Cys Gly Ala Leu 245 250 255 Val Asp Thr Leu Ala Pro Leu Leu Ser Thr Gly Thr Arg Gly Val 260 265 270 Arg Arg Val Arg Pro Gly Asp Val Gly Thr Val Glu Tyr Ala Gly 275 280 285 His Arg Arg Thr Ala Glu Arg Val Leu Leu Ser Ala Asp Thr Leu 290 295 300 Asp Ser Pro Val Thr Ser Leu Ala Asp Val Pro Arg Trp Leu Glu 305 310 315 Ala Tyr Arg Arg Ala His Arg Phe His Val Glu Pro Ile Pro Phe 320 325 330 Asp Arg Leu Arg Arg Trp Ser Phe Glu Pro Gly Thr Gly Asp Leu 335 340 345 Arg His Glu Thr Gly Arg Phe Phe Ser Val Glu Gly Leu Arg Thr 350 355 360 Ser Ser Asp Ala Asp Pro Val Ala Arg Val Gln Pro Ile Ile Val 365 370 375 Gln Pro Glu Val Gly Leu Leu Gly Ile Leu Ala Arg Glu Phe Asp 380 385 390 Gly Val Leu His Phe Leu Met Gln Ala Lys Pro Glu Pro Gly Asn 395 400 405 Val Asn Gly Leu Gln Leu Ser Pro Thr Val Gln Ala Thr Arg Ser 410 415 420 Asn Phe Asp Glu Val His His Gly Arg Ser Thr Pro Phe Leu Asp 425 430 435 His Phe Ile His Arg Pro Gly Arg Arg Val Leu Ile Asp Thr Ile 440 445 450 Gln Ser Glu Gln Gly Asp Trp Phe Leu His Lys Arg Asn Arg Asn 455 460 465 Met Val Val Glu Ile Asp Thr Asp Ile Glu Ala Asp Ala Thr Phe 470 475 480 Arg Trp Leu Thr Leu Gly Gln Ile Arg Arg Leu Met Leu Gln Asp 485 490 495 Asp Leu Val Asn Met Asp Thr Arg Ser Val Leu Ala Cys Leu Pro 500 505 510 Thr Ala His Gly Ala Pro Asp Asp Asp Glu Asp Phe Pro Ala Ala 515 520 525 Leu Arg Arg Ser Phe Tyr Gly Glu Ala Ala Pro Leu His Asp Leu 530 535 540 His Ala Ile Thr Ser Cys Leu Thr Asp Val Arg Ala Leu Arg Val 545 550 555 Leu Arg Gln Gln Ser Val Pro Leu Asp Asp Ala Arg Arg Asp Gly 560 565 570 Trp Glu Arg Thr Glu Ser Thr Ile Arg His Arg Ser Gly Lys His 575 580 585 Phe Glu Ile Met Ala Val Glu Val Thr Ala Glu Arg Arg Glu Val 590 595 600 Ala Ser Trp Thr Gln Pro Leu Leu Arg Pro Cys Ser Gln Gly Leu 605 610 615 Val Ala Leu Ile Thr Arg Arg Ile Asn Gly Val Leu His Ala Leu 620 625 630 Val Glu Ala Arg Ser Asp Val Gly Thr Leu Asn Val Ala Glu Phe 635 640 645 Gly Pro Thr Val Gln Cys Arg Pro Ala Glu Ser Asp Gly Met Ser 650 655 660 Pro Pro Tyr Leu Asp Gln Val Leu Thr Ala Gly Ala Asp Arg Ile 665 670 675 Arg Tyr Asp Val Val Gln Ser Glu Glu Gly Gly Arg Phe Tyr His 680 685 690 Ala Arg Asn Arg Tyr Met Val Val Glu Ala Gly Pro Glu Leu Asp 695 700 705 Thr Gly Cys Pro Pro Gly Phe Cys Trp Ala Thr Phe Gly Gln Leu 710 715 720 Thr Glu Leu Leu Ala His Gly Asn Tyr Leu Asn Val Glu Leu Arg 725 730 735 Thr Leu Val Ala Cys Ala His Ala Ser Tyr 740 745 <210> 23 <211> 382 <212> Pro <213> Streptomyces spiramyceticus WSJ-1£© <400> 1 Met Ile Asn Leu Phe Gln Pro Gln Met Gly Ala Glu Glu Leu Ala 5 10 15 Ala Ile Ala Gly Val Phe Asp Asp Gln Trp Leu Gly His Gly Pro 20 25 30 Arg Thr Lys Ala Phe Glu Ser Ala Phe Ala Asp His Leu Gly Val 35 40 45 Gly Pro Glu His Val Val Phe Leu Asn Ser Gly Thr Ala Gly Leu 50 55 60 Phe Leu Ala Leu Glu Ser Leu Gly Leu Gln Pro Asp Asp Glu Val 65 70 75 Val Leu Pro Ser Pro Ser Phe Leu Ala Ala Ala Asn Ala Val Gln 80 85 90 Leu Thr Gly Ala Arg Pro Val Phe Cys Asp Val Asp Pro Arg Thr 95 100 105 Leu Asn Pro Ala Leu Glu His Ile Glu Gln Ala Val Thr Ala Arg 110 115 120 Thr Arg Ala Val Ile Ala Leu His Tyr Gly Gly Tyr Pro Gly Asp 125 130 135 Ile Val Arg Ile Ala Glu His Cys Arg Asn Gln Gly Ile Thr Leu 140 145 150 Ile Glu Asp Ala Ala Cys Ser Val Ala Ser Arg Ile Asp Gly Arg 155 160 165 Val Val Gly Thr Phe Gly Asp Leu Ala Met Trp Ser Phe Asp Ala 170 175 180 Met Lys Val Leu Val Thr Gly Asp Gly Gly Met Ile Tyr Val Lys 185 190 195 Asp Pro Gly Ala Ala Ala Arg Ile Arg Arg Leu Ala Tyr His Gly 200 205 210 Leu Thr Gln Ser Ser Gly Leu Gly Tyr Ala Arg Val Ser Ala Arg 215 220 225 Trp Trp Glu Met Asp Val Pro Glu Pro Gly Arg Arg Val Ile Gly 230 235 240 Asn Asp Leu Thr Ala Ala Ile Gly Ala Val Gln Leu Arg Arg Leu 245 250 255 Pro Asp Phe Val Ala Arg Arg Lys Glu Ile Val Ala Leu Tyr Glu 260 265 270 Ser Glu Leu Arg Thr Met Glu Gly Val Ser Thr Pro Pro Ala Leu 275 280 285 Pro Glu Gly His Glu Ser Thr His Tyr Phe Tyr Trp Ile Gln Leu 290 295 300 Pro Pro Gly Val Arg Asp Arg Val Ala Arg Asp Leu Leu Thr Asp 305 310 315 Gly Ile Tyr Thr Thr Phe Arg Tyr Ala Pro Leu His Lys Val Pro 320 325 330 Ala Tyr Gly His Ala Gly Arg Glu Leu Pro Gly Val Glu Trp Ala 335 340 345 Ser Glu Arg Thr Leu Cys Leu Pro Leu His Pro Gly Leu Ser Asp 350 355 360 Ala Asp Val Leu Thr Val Val Ser Ser Leu Arg Lys Ala Leu Asn 365 370 375 Ala Gly Ala Gln Ala Pro Ala 380 <210> 24 <211> 239 <212> Pro <213> Streptomyces spiramyceticus WSJ-1£© <400> 1 Met Tyr Glu Asn Asp Ser Ala Ala Glu Val Tyr Asp Leu Leu Tyr 5 10 15 Gln Asp Arg Lys Asp Tyr Ala Gly Glu Ala Ala Arg Val Thr Gly 20 25 30 Leu Ile Arg Glu Arg Thr Pro Asn Ala Ser Ser Leu Leu Asp Ile 35 40 45 Ala Cys Gly Thr Gly Thr His Leu Glu Ala Phe Ala Lys Leu Tyr 50 55 60 Asp Arg Val Ser Gly Leu Glu Leu Ser Glu Trp Met Ala Ala Arg 65 70 75 Ala Glu Glu Arg Leu Ser Asp Val Thr Leu His Arg Gly Asp Met 80 85 90 Arg Ser Phe Asn Leu Gly Glu Thr Phe Asp Ala Val Val Cys Met 95 100 105 Phe Ser Ser Ile Gly Tyr Leu Glu Thr Ala Ala Asp Leu Glu Asp 110 115 120 Ala Ile Ala Ala Met Ser Arg His Leu Ser Ala Asp Gly Val Leu 125 130 135 Ala Val Glu Pro Trp Tyr Phe Pro Asp Thr Phe Leu Asp Gly Tyr 140 145 150 Val Ser Thr His Ala Leu Arg Thr Glu Ser Gly Asp Gln Gly Val 155 160 165 Ala Arg Val Ala His Ser Thr Arg Glu Gly Lys Lys Thr Arg Met 170 175 180 Glu Ile His Tyr Leu Ile Ala His Thr Thr Asp Gly Ile Arg His 185 190 195 Arg Ser Glu Val Asp Tyr Leu Thr Leu Phe Ser Arg Ala Glu Tyr 200 205 210 Glu Thr Ala Tyr Arg Lys Ala Gly Leu His Val Glu Tyr Val Glu 215 220 225 Thr Gly Asn Gly Ser Pro Gly Phe Phe Leu Gly Thr Arg Ala 230 235 <210> 25 <211> 670 <212> Pro <213> Streptomyces spiramyceticus WSJ-1£© <400> 1 Met Ser Tyr Leu Asp Tyr Gly Glu Glu Ala Ser Glu Glu Asp Glu 5 10 15 Ser Asp Asp Ala Leu Thr Phe Leu Glu Phe Val Ala Arg Ser Ala 20 25 30 Pro Arg Ser Glu Tyr Asp Arg Leu Met Ala Arg Ala Glu Arg Ala 35 40 45 Gly Ala Asp Glu Glu Arg Met Arg Arg Leu Glu Arg Phe Asn Arg 50 55 60 Leu Ala Leu Thr Ala Gln Ser Met Ile Glu Tyr Arg Arg Asp Arg 65 70 75 Glu Ala Glu Leu Ala Ala Leu Val Asp Ala Ala His Glu Phe Val 80 85 90 Ala Ala Gln Gln Tyr Lys Asp Leu Leu Glu Ser Val Ala Arg Arg 95 100 105 Ala Arg Leu Leu Leu Lys Leu Asp Val Ala Tyr Val Ser Leu His 110 115 120 Gln Glu Asp Leu His His Glu Asp Arg Pro Gly Thr Val Val Leu 125 130 135 Ser Ala Asp Gly Asn Ala Val Lys Val Ala Asp Ser Tyr Arg Leu 140 145 150 Pro Ala Asp Gly Gly Leu Gly Gly Met Val Arg Thr Cys His Ala 155 160 165 Pro Phe Trp Thr Pro Asp Tyr Leu Gly Asp Ser Ser Phe Val His 170 175 180 Val Glu Thr Val Asp Asp Ile Val Arg Ala Glu Gly Leu Arg Ala 185 190 195 Val Leu Ala Val Pro Leu Cys Val Gly Asp Asp Ser Val Gly Val 200 205 210 Leu Tyr Val Ala Asp Arg Gln Val Arg His Leu Thr Pro Asn Glu 215 220 225 Val Thr Leu Leu Cys Ser Leu Ala Asp Leu Ala Ala Val Ala Ile 230 235 240 Glu Arg Ile Arg Leu Val Glu Glu Leu Arg Asp Thr Ile Gly Arg 245 250 255 Leu Arg Glu Asp Val Gly Glu Ala Arg Ala Ala Leu Ala Gly Thr 260 265 270 Arg Arg Ser Ala Asp Leu Gln Ser His Leu Ile Thr Gln Val Leu 275 280 285 Glu Arg Arg Gly Ala Asp Ala Leu Leu Ala Ala Ala Ala Glu Ser 290 295 300 Leu Gly Gly Gly Thr Ser Leu Cys Ser Pro Leu Gly Arg Pro Leu 305 310 315 Ala Glu Tyr Gly Asn Leu Arg Pro Val Ala Pro Ala Asp Leu Arg 320 325 330 Ala Ala Cys Arg Arg Ala Ala Glu Thr Gly Arg Pro Thr Pro Val 335 340 345 Ala Pro Gly Tyr Trp Thr Val Pro Leu Tyr Pro Gly Glu Tyr Asn 350 355 360 Ala Gly Phe Leu Leu Thr Asp Val Gly Pro Glu Ala Asp His Thr 365 370 375 Val Val Pro Leu Leu Pro Met Val Ala Arg Thr Leu Ala Leu His 380 385 390 Leu Arg Ile Gln Arg Asn Asp Ser Thr Lys Ala Gln Ser His Gln 395 400 405 Asp Phe Phe Asp Asp Leu Val Gly Ala Pro Arg Ser Pro Ala Leu 410 415 420 Leu Arg Glu Arg Ala Leu Leu Phe Ser Leu Ser Phe Arg Arg Pro 425 430 435 His Val Val Leu Val Ala Ser Gly Pro His Gly Ala Ser Ala Arg 440 445 450 Leu Glu Ser Ser Gly Ala Asp Tyr Ala Lys Glu Leu Gly Gly Leu 455 460 465 Cys Ser Val Arg Asp Gly Ala Val Val Leu Leu Leu Pro Gly Asp 470 475 480 Asp Pro Val Ala Val Ala Gln Thr Ala Ala Pro Glu Leu Thr Asp 485 490 495 Arg Val Gly His Pro Val Thr Val Gly Ala Ala Gly Pro Ala Ser 500 505 510 Thr Val Asp Gly Ile Ser Asp Ala His Arg Glu Ala Ala Gln Cys 515 520 525 Leu Glu Thr Leu Arg Ala Leu Gly Gly Asp Gly Gly Thr Ala Cys 530 535 540 Ala Ser Asp Leu Gly Phe Leu Gly Met Leu Leu Ala Glu Glu Asn 545 550 555 Asp Val Pro Gly Tyr Ile Lys Thr Thr Ile Gly Pro Val Ile Asp 560 565 570 Tyr Asp Thr His Arg Phe Thr Asp Leu Ile Pro Thr Leu Arg Val 575 580 585 Tyr Leu Glu Ser Gly Arg Ser Pro Thr Arg Ala Ala Glu Thr Leu 590 595 600 Arg Val His Pro Asn Thr Val Ser Arg Arg Leu Glu Arg Ile Gly 605 610 615 Gln Leu Leu Gly Glu Asp Trp Gln Gly Pro Glu Arg Val Leu Asp 620 625 630 Ile Gln Leu Ala Leu Arg Leu Tyr Gln Val Arg Ser Ala Leu Ser 635 640 645 Ser Arg Ser Ala Ser Ala Ser Leu Pro Pro Arg Pro Ala Pro Ala 650 655 660 Ser Arg Thr Val Leu Gly Ser Gln Arg Glu 665 670 <210> 26 <211> 354 <212> Pro <213> Streptomyces spiramyceticus WSJ-1£© <400> 1 Met His Arg Arg Val Gln Arg Arg Leu Ser His Ala Leu Thr Arg 5 10 15 Ala Arg Asp Leu Val Pro Lys Gly Pro Arg Ser Arg Leu Lys Thr 20 25 30 Arg Pro Pro Asp Gly Asp Pro Arg Arg Arg Ala Gly Ala Gly Ala 35 40 45 Leu Ala Ala Pro Leu Phe Pro Glu Pro Gly Arg Leu Arg Lys Arg 50 55 60 Gln Asp Leu Pro Met Asn Gly Cys Gln Val Ala Val Gly Ala Val 65 70 75 Val Arg Pro Arg Asn Phe Ala Arg Leu Arg Ala Pro Ser Cys Gly 80 85 90 Lys Gly Glu Ala Ser Val Asn Phe Arg Arg Arg Tyr Gly Asn Ser 95 100 105 Cys Pro Pro Val Arg Cys Ala Gly Ser Gly Arg Arg Phe Arg Gln 110 115 120 Arg Arg Pro Leu Cys His Val Arg Leu Ala Asp Cys Leu Gly Ala 125 130 135 Ser Tyr Val Pro Leu Thr Ser Thr Gly Ser Asp Ala Gly Ser Arg 140 145 150 Thr Pro Asp Arg Val His Arg Ser Thr Arg Ala Thr Ser Ser Leu 155 160 165 Arg Ser Thr Cys Pro Ser Ala Ser Thr Gly Thr Glu Pro Glu Gly 170 175 180 Ser Val Pro Gly Pro Gly Pro Ser Arg Ala Gly Arg Gly Pro His 185 190 195 Asp Arg Pro Ile Arg Ser Ala Ala Ile Ala Glu Asn Thr Ala Glu 200 205 210 Pro Pro Ala Arg Arg Val Gly Arg Ile Lys Pro Cys Arg Leu Ile 215 220 225 Arg Leu Glu Gln His Ile Asp Pro Arg Gly Ser Leu Ser Val Val 230 235 240 Glu Ser Gly Val Thr Val Asp Phe Pro Val Gln Arg Val Tyr Tyr 245 250 255 Met His Gly Gln Thr Gln Ser Ser Pro Pro Arg Gly Leu His Ala 260 265 270 His Arg Thr Leu Glu Gln Leu Val Ile Ala Val His Gly Ala Phe 275 280 285 Ser Ile Thr Leu Asp Asp Gly Phe Gln His Ala Thr Tyr Arg Leu 290 295 300 Asp Glu Pro Gly Ala Gly Leu Cys Ile Gly Pro Met Val Trp Arg 305 310 315 Val Leu Lys Asp Phe Ala Pro Asp Thr Val Ala Leu Val Leu Ala 320 325 330 Ser Gln His Tyr Glu Glu Ser Asp Tyr Tyr Arg Asp Tyr Asp Thr 335 340 345 Phe Leu His Asp Ala Arg Ser Leu Thr 350 <210> 27 <211> 550 <212> Pro <213> Streptomyces spiramyceticus WSJ-1£© <400> 1 Met Ser Ile Ala Gln Phe Ala Leu His Asp Val Ile Lys Arg Tyr 5 10 15 His Asp Cys Val Val Leu Asp Arg Val Gly Phe Ser Ile Lys Pro 20 25 30 Gly Glu Lys Val Gly Val Ile Gly Asp Asn Gly Ser Gly Lys Ser 35 40 45 Thr Leu Leu Lys Val Leu Ala Gly Arg Glu Gln Pro Asp Asn Gly 50 55 60 Met Leu Thr Val Val Ala Pro Gly Gly Ile Gly Tyr Leu Ala Gln 65 70 75 Thr Leu Glu Leu Pro Leu Asp Ala Thr Val Gln Asp Ala Val Asp 80 85 90 Leu Ala Leu Ser Asp Leu Arg Glu Leu Glu Ala Ser Met His Glu 95 100 105 Val Glu Ala Glu Leu Thr Glu Arg Asp Glu Asp Gly Ser Glu Arg 110 115 120 Glu Leu Ser Ala Leu Leu Gln Arg Tyr Ala Gly Leu Val Glu Gln 125 130 135 Tyr Gln Ala Arg Gly Gly Tyr Glu Ala Asp Val Arg Val Glu Val 140 145 150 Ala Leu His Gly Leu Gly Leu Pro Ser Leu Asp Arg Asp Arg Lys 155 160 165 Leu Gly Thr Leu Ser Gly Gly Glu Arg Ser Arg Leu Ala Leu Ala 170 175 180 Ala Thr Leu Ala Ser Ala Pro Glu Leu Leu Leu Leu Asp Glu Pro 185 190 195 Thr Asn Asp Leu Asp Asp Arg Ala Met Glu Trp Leu Glu Asn His 200 205 210 Leu Gln Gly His Arg Gly Thr Val Ile Ala Val Thr His Asp Arg 215 220 225 Val Phe Leu Asp Arg Leu Thr Thr Thr Ile Leu Glu Val Asp Ser 230 235 240 Gly Arg Val Thr Arg Tyr Gly Asn Gly Tyr Glu Gly Tyr Leu Thr 245 250 255 Ala Lys Ala Val Glu Arg Glu Arg Arg Leu Arg Glu Tyr Glu Glu 260 265 270 Trp Arg Ala Glu Leu Glu Arg Asn Gln Gly Leu Ile Thr Ser Asn 275 280 285 Val Ala Arg Met Asp Asn Ile Pro Arg Lys Met Ser Leu Ser Val 290 295 300 Phe Gly His Gly Ala Tyr Arg Arg Arg Gly Arg Asp His Gly Ala 305 310 315 Met Val Arg Ile Arg Asn Ala Lys Gln Arg Val Ala Gln Leu Thr 320 325 330 Glu Asn Pro Ala Leu Ala Pro Ala Asp Pro Leu Ser Phe Ala Ala 335 340 345 Arg Ile Asp Thr Ala Gly Pro Glu Ala Glu Glu Ala Val Ala Glu 350 355 360 Leu Thr Asp Val Arg Val Ala Asp Arg Leu Asp Val Asp Ser Leu 365 370 375 Lys Ile Arg Pro Gly Glu Arg Leu Leu Ile Thr Gly Pro Asn Gly 380 385 390 Ala Gly Lys Ser Thr Leu Leu Arg Val Leu Ser Gly Glu Leu Ala 395 400 405 Pro Asp Ser Gly Ser Val Arg Val Gly Cys Arg Val Gly His Leu 410 415 420 Arg Gln Asp Glu Thr Pro Trp Ser Pro Glu Leu Thr Val Leu Arg 425 430 435 Ala Phe Ala His Gly Arg Glu Gly Tyr Leu Glu Asp His Ala Glu 440 445 450 Lys Leu Leu Ser Leu Gly Leu Phe Ser Pro Ser Asp Leu Arg Arg 455 460 465 Arg Val Lys Asp Leu Ser Tyr Gly Gln Arg Arg Arg Ile Glu Ile 470 475 480 Ala Arg Leu Val Ser Asp Pro Met Asp Leu Leu Leu Leu Asp Glu 485 490 495 Pro Thr Asn His Leu Thr Pro Val Leu Val Glu Glu Leu Glu Gln 500 505 510 Ala Leu Val Asp Tyr Arg Gly Ala Val Val Val Val Thr His Asp 515 520 525 Arg Arg Met Arg Ser Arg Phe Thr Gly Ala Arg Leu Ala Met Asp 530 535 540 His Gly Cys Ile Ala Glu Phe Ser Ala Gly 545 550 <210> 28 <211> 433 <212> Pro <213> Streptomyces spiramyceticus WSJ-1£© <400> 1 Met Gly Glu Thr Lys Asn Arg Ile Thr Glu Leu Val Arg Ala Tyr 5 10 15 His Arg Glu Gln Ala Thr Gly Asn Phe Val Pro Gly Thr Thr His 20 25 30 Val Pro Val Ser Gly Ala Val Leu Ser Glu Asp Asp Arg Leu Ala 35 40 45 Leu Val Glu Thr Ala Leu Glu Met Arg Ile Ala Ala Gly Pro Ala 50 55 60 Ser Arg Ser Phe Glu Arg Gln Phe Ala Arg Tyr Leu Gly Leu Arg 65 70 75 Lys Ala His Leu Thr Asn Ser Gly Ser Ser Ala Asn Leu Leu Ala 80 85 90 Leu Ser Ala Leu Thr Ser Pro Gln Leu Glu Asp Arg Arg Leu Lys 95 100 105 Pro Gly Asp Glu Val Val Thr Val Ala Ala Gly Phe Pro Thr Thr 110 115 120 Val Asn Pro Ile Phe His Asn Glu Leu Val Pro Val Phe Val Asp 125 130 135 Val Glu Leu Gly Thr Tyr Asn Thr Thr Pro Glu Arg Ile Glu Arg 140 145 150 Ala Ile Gly Pro Arg Thr Arg Ala Ile Met Ile Ala His Ala Leu 155 160 165 Gly Asn Pro Phe Glu Ala Glu Glu Val Ala Arg Leu Ala Asp Glu 170 175 180 Arg Gly Leu Phe Leu Val Glu Asp Asn Cys Asp Ala Val Gly Ser 185 190 195 Arg Tyr Arg Gly Arg Leu Thr Gly Ser Phe Gly Asp Leu Ser Thr 200 205 210 Val Ser Phe Tyr Pro Ala His His Ile Ala Met Gly Glu Gly Gly 215 220 225 Cys Val Leu Thr Asp Asn Leu Ala Leu Ala Arg Ile Val Glu Ser 230 235 240 Leu Arg Asp Trp Gly Arg Asp Cys Trp Cys Glu Pro Gly Glu Asp 245 250 255 Asn Arg Cys Leu Lys Arg Phe Asp Gln Lys Met Gly Asp Leu Pro 260 265 270 Pro Gly Tyr Asp His Lys Tyr Ile Phe Ser His Val Gly Tyr Asn 275 280 285 Leu Lys Ser Thr Asp Leu Gln Ala Ala Leu Gly Leu Ser Gln Leu 290 295 300 Thr Arg Ile Glu Glu Phe Thr Asp Ala Arg Arg Ala Asn Trp Arg 305 310 315 Arg Met Arg Glu Thr Leu Asp Gly Leu Pro Gly Leu Leu Leu Pro 320 325 330 Glu Ala Thr Pro Gly Ser Asp Pro Ser Trp Phe Gly Phe Leu Ile 335 340 345 Thr Val Asp Pro Asp Ala Thr Tyr Ser Arg Ala Ala Leu Val Asp 350 355 360 His Leu Glu Ser Arg Arg Ile Ser Thr Arg Arg Leu Phe Gly Gly 365 370 375 Asn Leu Val Arg His Pro Ala Tyr Thr Gly Arg Gln Tyr Arg Val 380 385 390 Ser Gly Ala Leu Glu Asn Ser Asp Leu Ile Thr Asp Gln Thr Phe 395 400 405 Trp Ile Gly Val Phe Pro Gly Ile Thr Thr Glu Met Val Asp Tyr 410 415 420 Val Thr Asp Thr Val Arg Glu Phe Val Leu Lys His Ser 425 430 <210> 29 <211> 482 <212> Pro <213> Streptomyces spiramyceticus WSJ-1£© <400> 1 Met Thr His Pro Glu Asp Ser Ala Gly Thr Ser Gln Arg Ala Asp 5 10 15 Ala Leu Met Asn Asp Thr Leu Ala Ala Ala Asp Ala Glu Gly Trp 20 25 30 Asp Gly Glu Gln Phe Asp Arg Glu Asp Arg Ala Ser Leu Arg Arg 35 40 45 Val Ala Gly Leu Ser Thr Glu Leu Thr Asp Val Ser Glu Val Glu 50 55 60 Tyr Arg Lys Leu Arg Leu Glu Arg Val Val Leu Val Gly Ile Trp 65 70 75 Thr Ser Gly Thr Ala Ala Glu Ala Glu Ser Ser Leu Ala Glu Leu 80 85 90 Ala Ala Leu Ala Glu Thr Ala Gly Ala Leu Val Leu Asp Gly Val 95 100 105 Val Gln Arg Arg Gln Lys Pro Asp Pro Ala Thr Tyr Ile Gly Ser 110 115 120 Gly Lys Ala Ser Gln Leu Arg Asp Ile Val Glu Glu Thr Gly Ala 125 130 135 Asp Thr Val Val Cys Asp Gly Glu Leu Ser Pro Ser Gln Leu Met 140 145 150 His Leu Glu Glu Val Val Gly Val Lys Val Val Asp Arg Thr Ala 155 160 165 Leu Ile Leu Asp Ile Phe Ala Gln His Ala Gln Ser Arg Glu Gly 170 175 180 Lys Ala Gln Val Ala Leu Ala Gln Met Gln Tyr Met Leu Pro Arg 185 190 195 Leu Arg Gly Trp Gly Gln Ser Leu Ser Arg Gln Met Gly Gly Gly 200 205 210 Gly Gly Gly Gly Met Ala Thr Arg Gly Pro Gly Glu Thr Lys Ile 215 220 225 Glu Thr Asp Arg Arg Arg Ile Asn Asp Lys Met Ala Arg Leu Arg 230 235 240 Arg Glu Leu Glu Gln Leu Lys Thr Gly Arg Asp Val Lys Arg Glu 245 250 255 Glu Arg Arg Arg Asn Lys Val Leu Ser Val Ala Leu Ala Gly Tyr 260 265 270 Thr Asn Ala Gly Lys Ser Ser Leu Leu Asn Arg Leu Thr Gly Ala 275 280 285 Gly Val Leu Val Glu Asn Ala Leu Phe Ala Thr Leu Asp Thr Thr 290 295 300 Val Arg Arg Ala Thr Thr Pro Ser Gly Arg Thr Tyr Thr Ile Ala 305 310 315 Asp Thr Val Gly Phe Val Arg His Leu Pro His His Leu Val Glu 320 325 330 Ala Phe Arg Ser Thr Ile Glu Glu Val Ala Asp Ala His Leu Val 335 340 345 Leu His Val Val Asp Gly Ser His Pro Asp Pro Gly Ala Gln Leu 350 355 360 Ala Ser Val Arg Glu Val Leu Arg Asp Val Gly Ala Ala Glu Ser 365 370 375 Thr Glu Ile Val Val Val Asn Lys Ala Asp Val Ala Asp Pro Asp 380 385 390 Val Leu Ala Arg Leu Leu Glu Gln Glu Pro Asp Ala Ile Val Val 395 400 405 Ser Ala Arg Ser Gly Gln Gly Ile Asp Glu Leu Gln Glu Leu Ile 410 415 420 Asp Arg Leu Leu Pro His Pro Ala Val Glu Val Glu Val Val Ile 425 430 435 Pro Tyr Asp Glu Gly Gly Leu Val Ala Arg Ala His Asp Glu Gly 440 445 450 Glu Val Leu Ser Ala Glu His Thr Pro Glu Gly Thr Leu Leu Thr 455 460 465 Ala Leu Val His Pro Asp Leu Ala Ser Glu Leu Gln Ala His Pro 470 475 480 Arg Pro <210> 30 <211> 346 <212> Pro <213> Streptomyces spiramyceticus WSJ-1£© <400> 1 Met Arg Val Leu Ile Ile Gly Gly Ser Gln Phe Val Gly Arg Ala 5 10 15 Tyr Ala Ala Glu Ala Leu Ala Ala Gly His Glu Val Thr Thr Phe 20 25 30 Asn Arg Gly Val Ser Gly Thr Asp Leu Pro Gly Val Glu Ala Val 35 40 45 Arg Gly Asp Arg Glu Ala Ala Gly Asp Leu Glu Arg Leu Val Ser 50 55 60 Gly Arg Arg Trp Asp Ala Val Val Asp Thr Cys Gly Tyr Val Pro 65 70 75 Arg Thr Val Gly Ala Ser Ala Ala Ala Leu Ser Gly His Ala Asp 80 85 90 Ala Tyr Leu Tyr Val Ser Ser Ile Ala Cys Leu Pro Asp Trp Thr 95 100 105 Gln Ala Val Arg Pro Val Asp Asp Asp Ser Pro Ala Tyr Asp Cys 110 115 120 Pro Pro Asp Ala Gly Pro Asp His Ala Asp Gly Asp Tyr Gly Thr 125 130 135 Leu Lys Ala Gly Cys Glu Arg Ala Val Asp Gln His Phe Val Gly 140 145 150 Arg Thr Leu His Leu Arg Ala Gly Val Ile Leu Gly Pro His Asp 155 160 165 Asn Met Arg Met Leu Asp Ala Trp Leu Trp Arg Met Arg Ala Ala 170 175 180 Glu Gly Glu His Arg Arg Val Leu Ala Pro Gly Gly Pro Glu Val 185 190 195 Gly Met Arg Leu Ile Asp Val Arg Asp Val Ala Ala Phe Gly Leu 200 205 210 Asp Cys Leu Ala Glu Gly Arg Thr Gly Ala Tyr Ile Val Asn Pro 215 220 225 Pro Glu Lys Asn Thr Thr Phe Gly Asn Leu Leu Thr Glu Cys Val 230 235 240 Lys Ala Thr Gly Ser Ala Ala Glu Pro Val Trp Val Asp Asp Arg 245 250 255 Phe Phe Ala Asp His Gly Val Ser Pro Trp Thr Asp Leu Pro Leu 260 265 270 Trp Val Pro Asp Thr Ala Gln Asp Thr Leu Val Trp Ala Ala Gly 275 280 285 Ala Pro Arg Ala Arg Ala Ala Gly Leu Ala Cys Arg Pro Ile Ser 290 295 300 Glu Thr Val Arg Asp Ala Trp Glu Val Ile Arg Asp Gln Pro Val 305 310 315 Pro Glu Leu Pro Leu Ala Ala Gly Cys Gly Leu Ser Leu Ala Arg 320 325 330 Glu Arg Glu Leu Leu Ala Ala Trp Asp Ala Arg Gly Gly Ala Ala 335 340 345 Gly <210> 31 <211> 346 <212> Pro <213> Streptomyces spiramyceticus WSJ-1£© <400> 1 Met Thr Ala Leu Gly Thr Pro Ala Glu Pro Ser Ala Ala Pro Gly 5 10 15 Pro Pro Trp Pro Glu Ala Ser Pro Val Leu Arg Phe Gly Ala Ile 20 25 30 Gly Cys Gly Asp Ile Ala Gly Arg Arg Thr Leu Pro Ala Leu Leu 35 40 45 Ser Thr Pro Gly Thr Val Leu Thr Cys Val Gly Ser Arg Glu Pro 50 55 60 Glu Arg Ala Lys Ala Leu Gly Glu His Phe Gly Cys Glu Ala Val 65 70 75 Ala Pro Tyr Glu Ala Leu Leu Glu Arg Pro Asp Val Asp Ala Val 80 85 90 Tyr Ile Ala Val Pro Ser Met Leu His Ala Lys Trp Ala Ala Ala 95 100 105 Ala Leu Arg Ala Gly Lys His Val Leu Val Glu Lys Pro Ala Ala 110 115 120 Ala Asn His Ala Asp Ala Ala Arg Leu Phe Ala Met Ala Arg Glu 125 130 135 Arg Gly Leu Val Leu Met Glu Asn Phe Met Phe Leu His His Ser 140 145 150 Gln His Ala Thr Val Lys Val Leu Leu Glu Thr Gly Ala Ile Gly 155 160 165 Asp Leu Arg Thr Phe Ser Ala Ala Phe Thr Ile Pro Pro Arg Pro 170 175 180 Asp Asp Asp Met Arg Tyr Arg Pro Asp Ile Gly Gly Gly Ala Leu 185 190 195 Leu Asp Asn Gly Val Tyr Pro Leu Arg Ala Ala Ile His Phe Leu 200 205 210 Gly Pro Glu Leu Arg Leu Met Gly Ala Val Leu Arg Arg Glu Arg 215 220 225 Arg Arg Gly Val Val Val Ser Gly Ser Val Leu Leu Ala Ala Pro 230 235 240 Thr Gly Val Ala Ala His Leu Ala Phe Gly Met Glu His Gly Tyr 245 250 255 Arg Ser Ala Tyr Glu Leu His Gly Ser Thr Gly Ser Leu Ala Leu 260 265 270 Asn His Val Phe Thr Thr Pro Asp Ser His His Pro Val Leu Arg 275 280 285 Leu Ser Arg Gln Asp His Arg Glu Glu Arg Val Leu Pro Val Asp 290 295 300 Arg His Phe Val Asn Ile Leu Ser Val Phe Arg Arg Ala Val Thr 305 310 315 Arg Ala Glu Asn Ile Ser Ala Glu Ser Tyr Ala Ala Leu Arg Gln 320 325 330 Ala Ala Leu Val Asp Glu Ile Val Ala Arg Ala Glu Thr Val Thr 335 340 345 Val <210> 32 <211> 415 <212> Pro <213> Streptomyces spiramyceticus WSJ-1£© <400> 1 Met Ala Asp Ala Ile Thr Thr Glu Leu Ala Asp Arg Glu Leu Gly 5 10 15 Arg Arg Leu His Arg Ile Arg Gly Ala His Trp Tyr Phe Gly Asn 20 25 30 His Gly Asp Pro Tyr Ala Leu Ile Leu Arg Gly Gln Ala Asp Asp 35 40 45 Pro Ser Ala Tyr Glu Glu Arg Val Arg Asp Gly Gly Pro Leu Phe 50 55 60 Arg Ser His Ile Gly Thr Trp Val Thr Ala Asp Pro Glu Val Gly 65 70 75 Ala Ala Val Leu Gly Asp Pro Arg Phe Gly Ala Leu Asp Arg Ala 80 85 90 Gly Arg Arg Pro Glu Glu Tyr Leu Gln Pro Ser Pro Ala Ser Cys 95 100 105 Leu Gly Leu Asp Arg Ala Ala Tyr Leu Arg Leu Arg Arg Val Ala 110 115 120 Glu Pro Val Leu Gly Ala Gly Ala Ala Asp Glu Trp Arg Arg Leu 125 130 135 Ala Glu Asp Leu Gly Arg Arg Leu Leu Asp Gly Arg Gly Ser Gly 140 145 150 Phe Asp Leu Thr Ala Asp Phe Ala Arg Arg Leu Pro Ala Leu Val 155 160 165 Leu Ala Ala Trp Leu Gly Val Pro Asp Glu Arg Arg Glu Glu Trp 170 175 180 Glu Glu Leu Leu Arg Glu Ala Gly Pro Leu Leu Asp Ser Leu Leu 185 190 195 Cys Pro Gln Thr Leu Ala Ala Thr Arg Ala Ala Asp Ser Ala Ala 200 205 210 Glu Gly Leu Arg Thr Leu Leu Gly Lys Val Ala Val Ala Arg Ser 215 220 225 Asp Gly Ala Gly Asp Gly Ala Leu Gly Arg Met Val Ala Ala Gly 230 235 240 Ala Ala Pro Asp Asp Ala Val Ala Ala Ala Met Cys Leu Val Leu 245 250 255 Ser Ala Ala Glu Thr Thr Thr Thr Leu Val Cys Asp Ala Val Arg 260 265 270 Leu Leu Leu Asp Arg Pro Arg Trp Trp Arg Ala Leu Cys Asp Ser 275 280 285 Pro Ala Leu Ala Pro Ala Ala Val Arg His Thr Leu Arg Tyr Val 290 295 300 Pro Pro Val Arg Leu Glu Ser Arg Val Ala His Glu Asp Val Ala 305 310 315 Pro Thr Gly His Pro Leu Pro Ala Gly Ser His Val Val Val Leu 320 325 330 Val Ser Ala Ala Arg Arg Gly Ala Ala Pro Asp Ala Gly Pro Ala 335 340 345 Asp Leu Thr Asn Val Pro Thr Ala Ala Gly Ala Gly Leu Pro Asp 350 355 360 Asp Leu Tyr Phe Ala Leu Ser Gly Glu Phe Val Gly Arg Thr Ala 365 370 375 Glu Thr Ala Leu Gly Val Leu Ala Glu Val Ala Pro Arg Leu Arg 380 385 390 Arg Glu Gly Asp Ile Val Arg Arg Arg Arg Ser Pro Val Leu Gly 395 400 405 Arg Tyr Ala Arg Phe Pro Val Ala Tyr Ser 410 415 <210> 33 <211> 422 <212> Pro 213Streptomyces spiramyceticus WSJ-1£© <400> 1 Met Arg Val Leu Val Thr Ser Ile Pro His His Thr His Tyr Tyr 5 10 15 His Leu Val Pro Leu Ile Trp Ala Leu Arg Ala Ser Gly His Glu 20 25 30 Val Val Ala Ala Gly Gln Pro Ser Leu Ile Asp Ala Ile Thr Ser 35 40 45 Ser Gly Ile Pro Gly Phe Pro Leu Ala Glu Glu Glu Ser Leu Ala 50 55 60 Gln Ile Phe Glu Glu Val Glu Gly Asp Leu Gln Pro Tyr Gln His 65 70 75 Gly Ile Asp Glu Phe Asp Phe Leu Gly Thr Leu Gln Asp Ala Leu 80 85 90 Asp Trp Glu Lys Leu Leu Ala Gln Gln Val Ile Leu Ser Gly Leu 95 100 105 Trp Leu Glu Pro Leu Asn Gly Ala Thr Thr Leu Asp Ser Ile Val 110 115 120 Asp Phe Ala Arg Ser Trp Lys Pro Asp Leu Val Leu Trp Glu Pro 125 130 135 Phe Thr Tyr Ala Gly Pro Val Ala Ala Arg Ala Cys Gly Ala Ala 140 145 150 His Ala Arg Val Leu Trp Gly Pro Asp Thr Ile Gly Leu Met Arg 155 160 165 Thr Lys Phe Leu Gln Ala Gln Ala Gln Gln Pro Glu Glu His Arg 170 175 180 Asp Asp Pro Ile Ala Glu Trp Leu Thr Trp Ala Leu Glu Arg Tyr 185 190 195 Gly Cys Asp Phe Arg Glu Glu Asp Val Leu Gly Gln Trp Ser Val 200 205 210 Asp Pro Met Ala Glu Gly Val Ser Leu Gly Leu Asp Leu Pro Thr 215 220 225 Val Pro Met Arg Tyr Thr Pro Tyr Asn Gly Ser Ala Val Ile Pro 230 235 240 Asp Trp Leu Thr Glu Glu Pro Lys Arg Pro Arg Val Cys Leu Thr 245 250 255 Leu Gly Val Ser Ser Arg Glu Tyr Gly Glu Asp Glu Val Pro Val 260 265 270 Gln Lys Phe Ile Glu Ala Leu Ala Asp Leu Asp Ile Glu Leu Val 275 280 285 Ala Thr Leu Asp Asp Ala Gln Arg Asp Leu Leu Pro Arg Ile Pro 290 295 300 Asp Asn Thr Arg Ile Val Asp Phe Val Pro Met Asp Ala Leu Leu 305 310 315 Pro Thr Cys Ser Ala Ile Ile Asn His Ser Gly Ser Gly Thr Cys 320 325 330 Asn Thr Ala Ala Leu His Gly Val Pro Gln Ile Ile Leu Gly Asn 335 340 345 Ile Leu Asp Ala Ala Val Arg Gln His Met Phe Ala Gln Ser Ser 350 355 360 Ala Ala Leu Thr Phe Ala Pro Glu Glu Val Thr Gly Glu Ser Leu 365 370 375 Arg Ser Ala Leu Val Arg Leu Leu Gly Glu Pro Lys Phe Arg Asp 380 385 390 Gly Ala Gln Arg Leu Lys Glu Arg Met Arg Ala Met Pro Ser Pro 395 400 405 Ala Gly Ile Val Pro Thr Leu Glu Ser Leu Thr Ala Arg His Arg 410 415 420 Arg Ala <210> 34 <211> 391 121 Pro <213> Streptomyces spiramyceticus WSJ-1£© <400> 1 Met Arg Ala Leu Phe Thr Thr Ala Pro Leu Ala Gly His Leu Leu 5 10 15 Pro Leu Val Pro Thr Ala Trp Ala Leu Arg Ala Ala Gly His Asp 20 25 30 Val Leu Val Thr Thr Arg Glu Asn Phe Val Pro Val Ala Leu Arg 35 40 45 Ser Gly Leu Pro Ser Ser Ser Cys Gly Pro Ala Val Asp Phe Thr 50 55 60 Gly Thr Val Ala Asp Gly Pro Leu Ala Pro Ser Arg Asp Glu Ala 65 70 75 Gly Gln Arg Gly Val Leu Gly Gly Ala Leu Ala Arg Val Ala Arg 80 85 90 Gly Ser Leu Ala Gly Val Arg Arg Leu Ala Asp Val Trp Arg Pro 95 100 105 Asp Leu Ile Val Ser Glu Arg Ala Glu Phe Ala Gly Pro Leu Val 110 115 120 Ala Ala Ala Leu Gly Ile Pro Trp Val Arg Tyr His Trp Ser Val 125 130 135 Ser Cys Leu Glu Glu Tyr Arg Arg Ala Ala Glu Glu Glu Phe Ala 140 145 150 Pro Glu Leu Thr Ala Leu Gly Leu Asp Arg Phe Pro Asp Pro Ala 155 160 165 Arg Val Leu Asp Pro Trp Pro Val Ser Leu Arg Arg Pro Asp Ala 170 175 180 Val Ala His Asp Gly Ile Arg His Val Pro Ala His Gly Asp Ala 185 190 195 Pro Val Pro Glu Trp Ala Phe Thr Arg Gly Arg Arg Pro Arg Ile 200 205 210 Cys Val Thr Leu Gly Thr Met Leu Pro Arg Tyr Gly Ala Phe Gly 215 220 225 Val Arg Asp Phe Leu Ala Glu Leu Val Glu Glu Thr Arg Gly Ser 230 235 240 Asp Cys Glu Leu Leu Ile Ala Val Asp Asp Asp Ile Val Ala Arg 245 250 255 Trp Pro Pro Leu Pro Ala Ala Val Arg His Ala Gly Arg Leu Pro 260 265 270 Leu Ala Glu Val Leu Pro Ala Cys Asp Val Val Val His His Gly 275 280 285 Gly Gln Gly Thr Ser Leu Thr Ala Leu Ala Ala Gly Arg Pro Gln 290 295 300 Val Val Met Pro Arg Leu Asp Asp Gln Phe Asp Asn Ala Gln Ala 305 310 315 Leu Ala Ala Ala Asp Ala Ala Leu Leu Val Pro Pro Ser Leu Ala 320 325 330 Thr Pro Ala Ala Val Ala Ala Gly Cys Ala Glu Leu Leu Glu Asn 335 340 345 Ala Leu Tyr Ala Lys Ala Ala Ala Gly Leu Ala Glu Thr Met Ala 350 355 360 Leu Leu Pro Ser Pro Ser Ala Ala Val Gly Pro Leu Glu His Leu 365 370 375 Gly Pro Ala Pro Gly Met Leu Arg Ser His Ala Asn Glu Asp Ala 380 385 390 Val <210> 35 <211> 330 <212> Pro <213> Streptomyces spiramyceticus WSJ-1£© <400> 1 Met Ile Ser Glu Val Leu Asn Arg Ser Asn Asp Pro Arg Gly Pro 5 10 15 Leu Ile Thr Val Val Gly Ala Ser Gly Phe Ile Gly Ser Ala Leu 20 25 30 Val Ala Glu Leu Ala Arg Thr Pro Val Arg Leu Arg Ala Val Ser 35 40 45 Arg Arg Glu Ala Pro Val Pro Ala Gly Thr Pro Ala Ala Val Glu 50 55 60 Val Arg Arg Ala Asp Leu Ala Arg Pro Gly Glu Val Arg Asp Ala 65 70 75 Val Glu Gly Ala Asp Ala Val Val His Leu Ala Ala His Ile Gly 80 85 90 Gly Ala Gln Ser Trp Arg Ala Ala Asp Glu Arg Ser Ala Arg Val 95 100 105 Asn Val Gly Leu Leu His Asp Leu Val Asp Ala Phe Arg Gly Arg 110 115 120 Ser Gly Thr Leu Pro Ala Val Val Phe Ala Ser Thr Leu Gln Ala 125 130 135 Gly Ala Asp Val Ala Arg Gln Gly Ala Tyr Ala Arg Gln Lys Ser 140 145 150 Ala Ala Glu Glu Val Leu Leu Arg Ala Ala Ser Glu Gly Val Val 155 160 165 Arg Gly Val Val Leu Arg Leu Pro Thr Val Tyr Gly Arg Ser Pro 170 175 180 Leu Thr Gly Trp Thr Gly Arg Gly Val Val Ala Ser Val Ala Arg 185 190 195 Arg Ala Val Glu Asp Gly Pro Val Thr Met Trp His Asp Gly Thr 200 205 210 Val Gly Arg Asp Leu Leu His Val Glu Asp Ala Ala Arg Ala Phe 215 220 225 Val Ala Ala Leu Asp His Ala Ala Arg Leu Asp Gly Gly Thr Trp 230 235 240 Ser Val Gly Thr Gly Arg Leu Glu Pro Leu Gly Glu Val Phe Ser 245 250 255 Thr Ile Ala Gly Leu Val Ser Glu Arg Thr Gly Arg Pro Pro Val 260 265 270 Pro Val Val Ser Thr Glu Pro Pro Asp His Ala Glu Ala Gly Asp 275 280 285 Phe Asp Ser Pro Val Ser Asp Pro Ser Ala Phe Arg Ala Val Thr 290 295 300 Gly Trp Ser Pro Arg Val Pro Leu Gln Ala Gly Leu Ser Ala Val 305 310 315 Val Glu Thr Met Val Ala Ala Glu Ser Arg Gly Gly Ile Arg Gly 320 325 330 <210> 36 <211> 335 <212> Pro <213> Streptomyces spiramyceticus WSJ-1£© <400> 1 Met Ser Thr Asp Arg Asn Gln Ala Ala His Thr Arg Leu Gly Arg 5 10 15 Ser Ala Thr Leu Val Ser Arg Leu Trp Leu Gly Thr Val Asn Phe 20 25 30 Ser Gly Arg Val Glu Asp Ala Asp Ala Met His Leu Met Glu Thr 35 40 45 Ala Val Asp Arg Gly Ile Asn Cys Ile Asp Thr Ala Asp Ile Tyr 50 55 60 Gly Trp Arg Val His Lys Gly His Thr Glu Glu Leu Val Gly Arg 65 70 75 Trp Leu Ala Lys Ser Ala Ala Arg Arg Glu Asp Val Leu Leu Ala 80 85 90 Thr Lys Val Gly Gly Asp Met Ser Glu Arg Leu Asn Asp Gly Gly 95 100 105 Leu Ser Ala Arg His Ile Ile Thr Ala Cys Glu Gln Ser Leu Arg 110 115 120 Arg Leu Arg Val Asp His Ile Asp Leu Tyr Gln Met His Arg Ile 125 130 135 Asp His Ala Ala Pro Trp Asp Glu Ile Trp Gln Ala Met Asp Arg 140 145 150 Leu Val Ala Ser Gly Lys Val Thr Tyr Val Gly Ser Ser Asn Phe 155 160 165 Ala Gly Trp Asn Val Ala Ala Ala Gln Asp Ala Ala Arg Arg Arg 170 175 180 Arg Ser Leu Gly Leu Val Ser Glu Gln Cys Leu Tyr Asn Leu Ala 185 190 195 Val Arg His Ala Glu Leu Glu Leu Leu Pro Ala Ala Gln Ala Tyr 200 205 210 Gly Leu Gly Val Phe Ala Trp Ser Pro Leu His Gly Gly Leu Leu 215 220 225 Ser Gly Val Leu Arg Lys Leu Ala Ala Gly Thr Ala Val Lys Ser 230 235 240 Ala Gln Gly Arg Ala Gln Leu Leu Leu Pro Glu Leu His Ala Thr 245 250 255 Ile Glu Ala Tyr Glu Gly Phe Cys Asp Arg Ile Gly Ala Asp Pro 260 265 270 Ala Glu Val Gly Leu Ala Trp Val Leu Ser Arg Pro Gly Ile Ser 275 280 285 Gly Ala Val Ile Gly Pro Arg Thr Val Glu Gln Leu Asp Ser Ala 290 295 300 Leu Arg Ala Leu Asp Leu Val Leu Gly Glu Ala Glu Leu Ala Glu 305 310 315 Leu Asp Ala Ile Phe Pro Ala Leu Gly Asn Gly Gly Arg Ala Pro 320 325 330 Asp Ala Trp Ile Ser 335 <210> 37 <211> 410 <212> Pro <213> Streptomyces spiramyceticus WSJ-1£© <400> 1 Met Ile Ala Thr Ala Cys Arg Val Cys Gly Asn Lys Glu Leu Leu 5 10 15 Ser Val Leu Asp Leu Gly Glu Gln Ala Leu Thr Gly Val Phe Pro 20 25 30 Thr Ser Arg Glu Gln Val Val Pro Ser Val Pro Leu Glu Leu Val 35 40 45 Val Cys Ser Pro Ala Gly Cys Gly Leu Val Gln Leu Arg His Thr 50 55 60 Pro Asp Pro Asp Leu Met Tyr Gly Glu Gly Tyr Gly Tyr Arg Ser 65 70 75 Gly Ile Arg Pro Phe Met Val Asp His Leu His Gly Lys Val Ala 80 85 90 Ala Ile Arg Glu Leu Val Asp Leu Gly Pro Asp Asp Leu Val Val 95 100 105 Asp Ile Gly Ser Asn Asp Ala Thr Leu Leu Ser Gly Tyr Pro Ala 110 115 120 Asp Gly Pro Gln Leu Val Gly Ile Asp Pro Thr Gly Gly Lys Phe 125 130 135 Arg Glu Leu Tyr Pro Arg Asn Ala Glu Leu Ile Val Asp Tyr Phe 140 145 150 Thr Arg Glu Thr Phe Glu Ser Arg Phe Gly Ala Arg Arg Ala Lys 155 160 165 Val Val Thr Ser Ile Ala Met Phe Tyr Asp Leu Pro Asp Pro Leu 170 175 180 Arg Phe Met Ser Asp Val Arg Asp Val Leu Thr Glu Asp Gly Ile 185 190 195 Trp Met Met Glu Gln Ser Tyr Leu Pro Ala Met Leu Glu Ala Asp 200 205 210 Ala Tyr Asp Ile Val Cys His Glu His Leu Glu Tyr Tyr Ala Leu 215 220 225 Arg Gln Ile Glu Trp Met Ala Glu Arg Val Gly Leu Thr Val Ile 230 235 240 Arg Ala Glu Leu Thr Glu Val Tyr Gly Gly Ser Leu Cys Val Thr 245 250 255 Leu Ala Arg Ser Gly Ser Gln His Arg Lys Asp Asp Ala Gly Leu 260 265 270 Ala Arg Ile Arg Ala Arg Glu Ala Ala Ala Gly Leu Asp Gly Met 275 280 285 Ala Pro Phe Glu Gly Phe Ala Arg Arg Val Val Asn Gln Arg Gly 290 295 300 Ala Leu Arg Asp Phe Leu Asp Arg Ser Arg Glu Glu Gly Arg Leu 305 310 315 Thr Leu Gly Tyr Gly Ala Ser Thr Lys Gly Asn Val Ile Leu Gln 320 325 330 Tyr Cys Gly Ile Thr Glu Arg Asp Leu Pro Cys Ile Gly Glu Val 335 340 345 Ser Glu Glu Lys Ala Gly Arg Phe Thr Pro Gly Thr Ala Ile Pro 350 355 360 Ile Val Ser Glu Gln Asp Ala Lys Ala Gln Lys Pro Asp Gln Leu 365 370 375 Leu Val Leu Pro Trp Ile Tyr Arg Asp Gly Phe Val Glu Arg Glu 380 385 390 Arg Asp Phe Leu Asp Gly Gly Gly Arg Leu Ile Phe Pro Leu Pro 395 400 405 Ala Leu Asp Val Val 410 <210> 38 <211> 370 <212> Pro <213> Streptomyces spiramyceticus WSJ-1£© <400> 1 Met His Arg Asp Asn Ala Ala Glu Pro Leu Val Lys Cys Leu Val 5 10 15 Trp Asp Leu Asp Asn Thr Leu Trp Gln Gly Thr Leu Leu Glu Glu 20 25 30 Asp Glu Val Arg Leu Thr Pro Asp Val Leu Arg Thr Ile Ala Glu 35 40 45 Leu Asp Ala Arg Gly Ile Leu Gln Ala Val Ala Ser Lys Asn Asp 50 55 60 His Asp His Ala Trp Ala Lys Leu Glu Gln Leu Gly Val Ala Glu 65 70 75 Tyr Phe Val Leu Pro Gln Ile Gly Trp Gly Pro Lys Ser Lys Ser 80 85 90 Val Arg Glu Ile Ala Asp Arg Leu Asn Phe Ala Leu Gly Thr Leu 95 100 105 Ala Phe Ile Asp Asp Gln Pro Phe Glu Arg Ala Glu Val Thr His 110 115 120 Glu Leu Pro Glu Val Arg Thr Tyr Thr Ala Gly Gln Ala Thr Gly 125 130 135 Leu Thr Asp Leu Pro Glu Phe Ser Pro Asp Thr Val Thr Val Asp 140 145 150 Ser Arg Arg Arg Arg Ser Met Tyr Gln Ala Ser Phe Arg Arg Asp 155 160 165 Ala Glu Arg Ser Asp Phe Thr Gly Pro Asp Ala Asp Phe Leu Arg 170 175 180 Ser Leu Asp Ile Arg Met Arg Ile Ser Arg Ala Thr Pro His Glu 185 190 195 Leu Ser Arg Val Glu Glu Leu Thr Leu Arg Thr Ser Gln Met Asn 200 205 210 Ala Thr Gly Val His Tyr Ser Glu Asp Asp Leu Arg Ala Leu Ile 215 220 225 Asp Asp Pro Asp His Glu Val Leu Val Thr Thr Val Thr Asp Arg 230 235 240 Phe Gly Pro Tyr Gly Ala Val Gly Val Val Leu Leu Arg Arg Ser 245 250 255 Pro Asp Ala Trp Arg Ile Lys Leu Leu Ala Thr Ser Cys Arg Val 260 265 270 Val Ser Leu Gly Ala Gly Thr Ala Ile Leu Arg Trp Leu Thr Asp 275 280 285 Gln Ala His Arg Ala Gly Val His Leu Gly Ala Asp Phe Arg Ala 290 295 300 Thr Glu Arg Asn Arg Met Met Glu Val Ala Tyr Arg Phe Ala Gly 305 310 315 Phe Thr Asp Asp Pro Cys Pro Cys Gln Asp Ala Ser Ala Pro Thr 320 325 330 Gly Ala Ile Gly Arg Leu His Leu Met Pro Ser Pro Gln Pro Thr 335 340 345 Pro Asp Thr Leu Arg Leu Glu Ala Pro Asp Leu Ala Pro Gly Arg 350 355 360 Arg Pro Gly Pro Asp Ser Glu Arg Thr Pro 365 370 <210> 39 <211> 373 <212> Pro <213> Streptomyces spiramyceticus WSJ-1£© <400> 1 Met Ala Asp Ala Pro His Ala Ala Ala Ser Glu Ala Glu Glu Leu 5 10 15 Phe Thr Glu Leu Val Gly Asp Arg Ala Ala Glu Trp Asp Arg Thr 20 25 30 Gly Glu Leu Pro Leu Ser Leu Leu Arg Asp Leu Gly Ser Arg Gly 35 40 45 Leu Leu Cys Ala Gln Ala Pro Ala Ala His Gly Gly Leu Gly Trp 50 55 60 Ser Ser Arg Arg Asn Gly Glu Leu Thr Ala His Val Gly Ala Leu 65 70 75 Cys Ser Ser Leu Arg Ser Val Met Thr Ser Gln Gly Met Ala Ala 80 85 90 Trp Thr Leu Arg Arg Leu Ala Gly Ala Asp Gln Gln Ala Pro Leu 95 100 105 Thr Ser Arg Leu Thr Ser Gly Glu Leu Ala Ala Val Ala Phe Thr 110 115 120 Glu Ala Gly Ala Gly Ser Asp Leu Ser Ala Leu Arg Thr Arg Ile 125 130 135 Ala Phe Asp Gly Asp Glu Ile Val Val Asp Gly Val Lys Val Trp 140 145 150 Ala Thr Asn Ala Ala Tyr Ala Asp Leu Leu Val Val Phe Gly Arg 155 160 165 Thr Glu Glu Gly Ala Gly Ala Val Val Val Pro Ala Ser Ala Pro 170 175 180 Gly Val Arg Ile Glu Arg Ile Ala Asp Ala His Gly Cys Arg Ala 185 190 195 Ala Gly His Ala Asn Ile His Leu Asp Gly Val Arg Leu Pro Ala 200 205 210 Asp Ala Leu Leu Gln Gly His Asp Arg Thr Pro Ala Leu Leu Val 215 220 225 Thr Thr Ala Leu Ser Tyr Gly Arg Met Ser Val Ala Trp Gly Ser 230 235 240 Leu Gly Ile Leu Arg Gly Cys Leu Ala Ala Ala Val Arg His Thr 245 250 255 Ser Gly Arg Glu Gln Phe Gly Thr Arg Leu Ser Glu His Gln Leu 260 265 270 Val Ala Arg His Leu Ala Glu Leu Phe Ile Ala Glu Gln His Ala 275 280 285 Ala Arg Ala Cys Glu Tyr Ala Ser Ala Gln Trp Asp Glu Gly Ser 290 295 300 Pro Asp Met Val Ile Ala Ala Val Leu Ala Lys His Val Ala Ala 305 310 315 Thr Gly Ala Ala Arg Gly Ala Glu Arg Ala Val Gln Val Leu Ala 320 325 330 Ser Ala Gly Ala Arg Asp Gly His Val Val Ala Arg Ala His Arg 335 340 345 Asp Ala Lys Leu Met Glu Ile Ile Glu Gly Ser Asn Glu Ile Cys 350 355 360 Glu Leu Ile Leu Ala Arg His Ala Val Ser Ala Ala Gly 365 370 <210> 40 <211> 106 <212> Pro <213> Streptomyces spiramyceticus WSJ-1£© <400> 1 Met Thr Thr Thr Ser Gly Arg Pro Asp Ser Thr Gly Thr Thr Pro 5 10 15 Ala Asp AspGlu Val Ala Glu Glu Leu Leu Gly Phe Leu Ala Ala 20 25 30 Asn Thr Lys Thr Thr Trp Glu Arg Asp Gln Asp Leu Phe Ala Val 35 40 45 Gly Gly Met Ser Ser Leu Phe Ala Met Gln Leu Val Val His Leu 50 55 60 Glu Lys Thr His Gly Ile Val Ile Ser Gly Ala Asp Leu Met Leu 65 70 75 Asp Asn Phe Arg Thr Val Asp Ala Met Val Arg Leu Val Gly Arg 80 85 90 Leu Ala Ala Pro Gly Pro Thr Gly Glu Ala Thr Gly Pro Ala Gly 95 100 105 Gly <210> 41 <211> 288 <212> Pro <213> Streptomyces spiramyceticus WSJ-1£© <400> 1 Met Pro Asn Ser Asn Glu Asn Ser Pro Leu Val Val Leu Gly Ala 5 10 15 Gly Val Met Gly Thr Ala Ile Ala Ala Leu Ala Val Gly His Gly 20 25 30 His Pro Val Thr Leu Ile Asp Thr Ser Val Glu Ala Arg Ala Ala 35 40 45 Ala Pro Asp Thr Val Ala Leu His Leu Arg Thr Ala Arg Leu Met 50 55 60 Gly Ala Leu Pro His Asp Arg Pro Pro Gly Glu Leu Thr Val Glu 65 70 75 Asp Ala Leu Asn Ala Ile Ala Ala Val Thr Ala Val Ile Glu Ala 80 85 90 Val Thr Glu Asp Pro Lys Arg Lys Ala Glu Val Leu Ala Asp Leu 95 100 105 Ala Ser Ala Ala Arg Pro Gly Thr Leu Leu Ile Ser Asn Thr Ser 110 115 120 Gly Val Pro Ile Asp Glu Leu Ala Asp Ala Val Pro Arg Pro Glu 125 130 135 Asp Leu Val Gly Val His Phe Met Asn Pro Ala Tyr Val Ile Arg 140 145 150 Thr Val Glu Val Val Leu Gly Pro Arg Ser Gly Glu Ala Ala Ala 155 160 165 Glu Ser Thr Arg Glu Leu Leu Ser Gly Leu Gly Arg Arg Gly Ile 170 175 180 Val Val Gly Asp Gly Ala Gly Phe Val Thr Ser Arg Leu Leu His 185 190 195 Arg Met Leu Asn Asp Ala Ile Ala Val Val His Glu Gly Arg Ala 200 205 210 Thr Pro Glu Thr Val Asp Ala Leu Met Arg Asp Cys Ile Gly His 215 220 225 Arg Thr Gly Pro Leu Ala Thr Ala Asp Leu Ile Gly Leu Asp Asn 230 235 240 Leu Ala Asp Ser Leu Arg Val Met His Glu Arg Thr Gly Asp Pro 245 250 255 Ala Leu Arg Pro Ser Glu Leu Leu Leu Asp Lys Val Arg Gln Gly 260 265 270 Leu Leu Gly Arg Lys Ser Gly Arg Gly Phe Tyr Asp Tyr Gln Glu 275 280 285 Thr Met Gln <210> 42 <211> 405 <212> Pro <213> Streptomyces spiramyceticus WSJ-1£© <400> 1 Met Ala His Ile Ala Phe Phe Ile Leu Pro Val Ala Gly His Val 5 10 15 Asn Pro Thr Leu Gly Val Ala Glu Glu Leu Val Ala Arg Gly His 20 25 30 Arg Val Thr Tyr Ala Leu Ser Gly Glu Leu Ala Glu Arg Ala Arg 35 40 45 Leu Ile Gly Ala Glu Val Val Thr Tyr Pro Val Asp Lys Gln Arg 50 55 60 Phe Leu Asp Gln Met Val Pro Arg Gln Asp Ala Asp Glu Tyr Thr 65 70 75 Asp Glu Gly Glu Phe Val Arg Val Leu Glu Trp Leu Leu Asp Met 80 85 90 Thr Ala Gln Thr Leu Glu Pro Leu Glu Arg His Phe Ala Glu Asn 95 100 105 Arg Pro Asp Val Val Val Asn Asp Pro Ser Ser Leu Trp Thr Gly 110 115 120 Arg Leu Leu Ala Asp Arg Trp Asp Ile Pro Val Ile Arg Ser Thr 125 130 135 Pro Thr Tyr Ala Ala Asn Glu His Trp Ser Leu His Pro Pro Val 140 145 150 Asp Ser Ala Glu Pro Pro Asp Asp Pro Glu Leu His Lys Leu Leu 155 160 165 Ala Arg Ile Glu Arg Leu Leu Glu Glu Gln Gly Val Glu His Asp 170 175 180 Leu Ala Ala Phe Thr Gly Val Leu His Gly Gly Pro Ala Leu Leu 185 190 195 Tyr Met Pro Arg Ser Phe Gln Tyr Ala Gly Glu Thr Phe Asp Glu 200 205 210 Gln His His Phe Val Gly Pro Cys Pro Pro Arg Thr Ala Phe His 215 220 225 Gly Glu Trp Thr Pro Thr Asp Asp Asp Gly Arg Pro Leu Val Leu 230 235 240 Val Ser Leu Gly Thr Leu Tyr Asn Asp Arg Pro Asp Phe Phe Arg 245 250 255 Thr Cys Leu Glu Ala Phe Arg Asp Glu Pro Trp Asn Val Leu Leu 260 265 270 Val Leu Gly Gly Gly Val Pro Ala Ala Asp Leu Gly Pro Leu Pro 275 280 285 Asp Asn Val Arg Val His Asp Phe Val Ser Leu Arg Asp Val Leu 290 295 300 Pro His Thr Ala Val Val Val Asn His Gly Gly Met Ser Thr Ala 305 310 315 Met Glu Val Phe Ser His Glu Val Pro Val Val Ala Ile Pro Val 320 325 330 Met Pro Glu Pro Arg Ala Thr Ala Arg Arg Ile Val Glu Leu Gly 335 340 345 Leu Gly Asp Gln Leu Leu Asn Ser Glu Leu Thr Ala Glu Ser Leu 350 355 360 Arg Ala Thr Val Arg Arg Val Leu Glu Asp Ser Arg Ile Pro Ala 365 370 375 Asn Met Arg Lys Ile Arg Glu Gln Ile Thr Ala Ala Gly Gly Ala 380 385 390 Asn Ala Ala Ala Asp Ala Val Glu Gly Leu Leu Pro Gln Gly Ser 395 400 405 <210> 43 <211> 202 <212> Pro <213> Streptomyces spiramyceticus WSJ-1£© <400> 1 Met Leu Ile Thr Glu Thr Thr Val Pro Asp Val Phe Arg Ile Asp 5 10 15 Pro Glu Pro Ile Pro Asp His Arg Gly Arg Phe Tyr Glu Ala Val 20 25 30 Arg Gln Arg Pro Leu Glu Ala Ala Val Gly His Ser Ile Ala Val 35 40 45 Arg Gln Val Asn Phe Thr Val Ser Gly Arg Asn Val Leu Arg Gly 50 55 60 Leu His Ala Thr Thr Leu Pro Pro Gly Gln Gly Lys Ile Leu Thr 65 70 75 Cys Val Arg Gly Ser Val Leu Thr Met Val Val Asp Met Arg Val 80 85 90 Gly Ser Pro Ser Phe Gly Arg Tyr Glu Ala Val Arg Gln Asp Pro 95 100 105 Arg Ser Gly Thr Ala Leu Tyr Leu Pro Asp Gly Ile Gly Leu Gly 110 115 120 Tyr Val Ala Leu Val Asp Asp Thr Cys Met Asn Tyr Leu Cys Thr 125 130 135 His Glu Tyr Val Pro Gly Met Val Ile Asp Val Asp Ala Leu Asp 140 145 150 Pro Glu Leu Asp Leu Pro Trp Asp Leu Ala Asp Thr Pro Ile Arg 155 160 165 Ser Ala Arg Asp Ala Ala Ala Pro Ser Leu Arg Ala Ala Val Ser 170 175 180 Ala Gly Ile Leu Pro Thr Tyr Glu Glu Cys Leu Arg Val Arg Glu 185 190 195 Pro Leu Pro Ala Ala Leu Asp 200 <210> 44 <211> 390 <212> Pro <213> Streptomyces spiramyceticus WSJ-1£© <400> 1 Met Lys Phe Arg Thr Leu Glu Pro Ala Gly Thr Ala Pro Leu Thr 5 10 15 Gly Pro Ala Ala Gly His Asp Phe Asp Ser Leu Val Ser Glu Gly 20 25 30 Cys Ala Glu Leu Leu Gly Ser Leu Arg Arg Ala Asp Gln Arg Arg 35 40 45 Arg Gly Glu Gln Tyr Ile Arg Gly Leu Leu Thr Ala Gln Gly Arg 50 55 60 Lys Thr Ala Arg Asn Leu Ala Ala Phe Val Gly Glu Gly Ala Ala 65 70 75 Glu Gln Ser Leu His His Phe Val Ala Gly Ser Thr Trp Asp Trp 80 85 90 Gly Ala Val Arg Ala Ala Leu Ala Arg Tyr Val Asp Asp Arg Leu 95 100 105 Asn Pro Glu Ala Trp Val Ile Trp Pro Met Val Val Ser Lys Ala 110 115 120 Gly Val Arg Ser Val Gly Val Ser Arg Arg Phe Val Pro Asp Leu 125 130 135 Gly Arg Val Val Ser Cys Gln Gln Ser His Gly Leu Trp Leu Ala 140 145 150 Ser Gly Ala Thr Ala Ala Pro Val Ser Trp His Leu Thr Leu Gly 155 160 165 Gly Gly Arg Gly Gly Asp Gly Gly Ser Arg Gln Leu Gly Ala Pro 170 175 180 Gly Ala Leu Gly Glu Glu Glu Asn Val Val Arg Leu Val Ala Glu 185 190 195 Ala Ala Gln Ala Ser Arg Thr Ser Ala Arg Pro Val Val Met Asp 200 205 210 Ala Arg Ala Ala Val Leu Pro Arg Leu Val Arg Gly Leu Ser Leu 215 220 225 Val Gly Leu Pro Phe Met Val Arg Val Gly Gly Asn Leu Gln Leu 230 235 240 Ala Ser Ala Gly Gly Arg Gly Leu Val Asp His His Thr Ala Thr 245 250 255 Thr Ser Ala Gln Gln Leu Met Glu Gln Met Lys Arg Leu Ser Arg 260 265 270 Pro Val Glu Trp Gln Gly Ser Leu Ser Leu Val Ala Pro His Ala 275 280 285 Val Val Leu Pro Gly Val Val Pro Arg Arg Thr Leu Val Leu Met 290 295 300 Gly Val Trp Arg Gly Asn Arg Arg Arg Pro Ala Asp Leu Trp Leu 305 310 315 Thr Asp Leu Thr Ser Trp Asp Arg Gly Ala Leu Leu Arg Leu Ala 320 325 330 Met Leu Thr Glu Gln Val Asp Ala Asp Phe Glu Arg Val Ser Val 335 340 345 Gly Val Gly Met Arg Asp Phe Glu Gly Arg Ser Phe Gln Gly Trp 350 355 360 His Arg His Val Thr Leu Ala Ser Ile Ala His Thr Leu Arg Leu 365 370 375 Ala Gln Pro Ser Ala Arg Val Asp Phe Arg Gly Val Ala Ala Val 380 385 390 <210> 45 <211> 269 <212> Pro <213> Streptomyces spiramyceticus WSJ-1£© <400> 1 Met Thr Glu Leu Asp Thr Ile Ala Asn Pro Ser Asp Pro Ala Val 5 10 15 Gln Arg Ile Ile Asp Val Thr Lys Pro Ser Arg Ser Asn Ile Lys 20 25 30 Thr Thr Leu Ile Glu Asp Val Glu Pro Leu Met His Ser Ile Ala 35 40 45 Ala Gly Val Glu Phe Ile Glu Val Tyr Gly Ser Asp Ser Ser Pro 50 55 60 Phe Pro Ser Glu Leu Leu Asp Leu Cys Gly Arg Gln Asn Ile Pro 65 70 75 Val Arg Leu Ile Asp Ser Ser Ile Val Asn Gln Leu Phe Lys Gly 80 85 90 Glu Arg Lys Ala Lys Thr Phe Gly Ile Ala Arg Val Pro Arg Pro 95 100 105 Ala Arg Phe Gly Asp Ile Ala Ser Arg Arg Gly Asp Val Val Val 110 115 120 Leu Asp Gly Val Lys Ile Val Gly Asn Ile Gly Ala Ile Val Arg 125 130 135 Thr Ser Leu Ala Leu Gly Ala Ser Gly Ile Ile Leu Val Asp Ser 140 145 150 Asp Ile Thr Ser Ile Ala Asp Arg Arg Leu Gln Arg Ala Ser Arg 155 160 165 Gly Tyr Val Phe Ser Leu Pro Val Val Leu Ser Gly Arg Glu Glu 170 175 180 Ala Ile Ala Phe Ile Arg Asp Ser Gly Met Gln Leu Met Thr Leu 185 190 195 Lys Ala Asp Gly Asp Ile Ser Val Lys Glu Leu Gly Asp Asn Pro 200 205 210 Asp Arg Leu Ala Leu Leu Phe Gly Ser Glu Lys Gly Gly Pro Ser 215 220 225 Asp Leu Phe Glu Glu Ala Ser Ser Ala Ser Val Ser Ile Pro Met 230 235 240 Met Ser Gln Thr Glu Ser Leu Asn Val Ser Val Ser Leu Gly Ile 245 250 255 Ala Leu His Glu Arg Ile Asp Arg Asn Leu Ala Ala Asn Arg 260 265 <210> 46 <211> 388 <212> Pro <213> Streptomyces spiramyceticus WSJ-1£© <400> 1 Met Pro Leu Pro Lys His Leu Pro Ala Leu Gly Gly Met Arg Phe 5 10 15 Ile Ser Ala Leu Leu Val Phe Thr Ser His Ile Ser Thr Gln Pro 20 25 30 Phe Phe Lys Asn Thr Glu Ile Asn Ser Ala Leu Gln Phe Pro Leu 35 40 45 Asn Arg Leu Gly Pro Leu Thr Val Ser Phe Phe Phe Met Leu Ser 50 55 60 Gly Phe Val Leu Thr Trp Ala Gly Leu Pro Asp Lys Ser Lys Val 65 70 75 Asn Phe Trp Arg Arg Arg Thr Val Arg Ala Tyr Ser Leu His Leu 80 85 90 Pro Val Leu Leu Val Thr Leu Leu Ile Val Leu Ala Leu Asn Glu 95 100 105 Pro Asn Met Gly Arg Ser Val Trp Asp Gly Leu Leu Thr Asn Leu 110 115 120 Leu Leu Ile Gln Ala Trp Phe Pro Asp His His Glu Tyr Gly Ser 125 130 135 Met Asn Pro Val Ala Trp Ser Leu Ser Cys Glu Leu Phe Phe Tyr 140 145 150 Ala Met Phe Pro Phe Leu Phe Ala Phe Phe Thr Lys Val Arg Thr 155 160 165 Asp Arg Leu Trp Arg Trp Ala Ala Ala Val Ser Val Ala Ala Val 170 175 180 Ser Ile Pro Leu Val Ala Leu Leu Leu Pro Ala Ser Pro Pro Leu 185 190 195 Pro Trp Asp Pro Asp Met Pro Gln Leu Arg Trp Trp Phe Ile Tyr 200 205 210 Met Phe Pro Pro Val Arg Leu Leu Glu Phe Val Leu Gly Met Leu 215 220 225 Met Ala Gln Ile Val Ile Arg Gly Arg Trp Arg Gly Pro Arg Pro 230 235 240 Leu Ala Cys Val Ala Leu Phe Ser Ala Val Phe Ala Val Thr Phe 245 250 255 Ala Val Pro Asn His Tyr Asp Pro Gly Ala Leu Thr Val Pro Val 260 265 270 Ile Ala Leu Leu Leu Ala Ser Val Ala Val Gly Asp Val Arg Gly 275 280 285 Val Arg Ser Trp Leu Gly Thr Arg Thr Met Val Leu Leu Gly Glu 290 295 300 Leu Thr Phe Ala Phe Tyr Leu Val His Tyr Leu Ile Ile Gln Tyr 305 310 315 Gly His Arg Phe Ala Gly Gly Lys Gln Gly Tyr Tyr Arg Gln Trp 320 325 330 Asp Thr Pro Ala Ala Val Gly Leu Thr Leu Leu Ala Phe Thr Leu 335 340 345 Ala Leu Gly Gln Ser Ala Phe Leu His Phe Phe Val Glu Lys Pro 350 355 360 Val Met Arg Thr Leu Gly Arg Pro Arg Arg Ser Pro Asp Ala Gly 365 370 375 Ser Thr Pro Arg Ser Glu Pro Ala Pro Ser Gly Thr Pro 380 385