LISTADO DE SECUENCIAS <110> OSE IMMUNOTHERAPEUTICS <120> NUEVOS ANTICUERPOS ANTI-SIRPa Y SUS APLICACIONES TERAPÉUTICAS <130> F2173/8PCT <150> US 62/322,707 <151> 2016-04-14 <150> EP 17305182.2 <151> 2017-02-17 <160> 73 <170> PatentIn versión 3.5 <210> 1 <211> 7 <212> PRT <213> Homo sapiens <400> 1 Ser Leu Ile Pro Val Gly Pro 1 5 <210> 2 <211> 12 <212> PRT <213> Homo sapiens <220> <221> CARACTERÍSTICA_MISC <222> (1)..(1) <223> Xaa = G o A <400> 2 Xaa Arg Glu Leu Ile Tyr Asn Gln Lys Glu Gly His 1 5 10 <210> 3 <211> 10 <212> PRT <213> Homo sapiens <220> <221> CARACTERÍSTICA_MISC <223> Xaa = DV o T <220> <221> característica_misc <222> (9)..(9) <223> Xaa puede ser cualquier aminoácido de origen natural <400> 3 Lys Phe Arg Lys Gly Ser Pro Asp Xaa Glu 1 5 10 <210> 4 <211> 23 <212> PRT <213> Homo sapiens <400> 4 Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser Pro Arg 1 5 10 15 Asp Ile Thr Leu Lys Trp Phe 20 <210> 5 <211> 11 <212> PRT <213> Homo sapiens <400> 5 Ile Cys Glu Val Ala His Val Thr Leu Gln Gly 1 5 10 <210> 6 <211> 11 <212> PRT <213> Homo sapiens <400> 6 Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu Glu 1 5 10 <210> 7 <211> 12 <212> PRT <213> Homo sapiens <400> 7 Gly Arg Glu Leu Ile Tyr Asn Gln Lys Glu Gly His 1 5 10 <210> 8 <211> 11 <212> PRT <213> Homo sapiens <400> 8 Lys Phe Arg Lys Gly Ser Pro Asp Asp Val Glu 1 5 10 <210> 9 <211> 12 <212> PRT <213> Homo sapiens <400> 9 Ala Arg Glu Leu Ile Tyr Asn Gln Lys Glu Gly His 1 5 10 <210> 10 <211> 10 <212> PRT <213> Homo sapiens <400> 10 Lys Phe Arg Lys Gly Ser Pro Asp Thr Glu 1 5 10 <210> 11 <211> 7 <212> PRT <213> Homo sapiens <400> 11 Gly Arg Glu Leu Ile Tyr Asn 1 5 <210> 12 <211> 22 <212> PRT <213> Homo sapiens <400> 12 His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser Pro Arg Asp 1 5 10 15 Ile Thr Leu Lys Trp Phe 20 <210> 13 <211> 7 <212> PRT <213> Homo sapiens <400> 13 Ala Arg Glu Leu Ile Tyr Asn 1 5 <210> 14 <211> 5 <212> PRT <213> Secuencia Artificial <220> <223> Cadena pesada CDR1 <400> 14 Ser Tyr Trp Val His 1 5 <210> 15 <211> 17 <212> PRT <213> Secuencia Artificial <220> <223> Cadena pesada CDR2 <400> 15 Asn Ile Asp Pro Ser Asp Ser Asp Thr His Tyr Asn Gln Lys Phe Lys 1 5 10 15 Asp <210> 16 <211> 17 <212> PRT <213> Secuencia Artificial <220> <223> Cadena pesada CDR2 <400> 16 Asn Ile Asp Pro Ser Asp Ser Asp Thr His Tyr Ser Pro Ser Phe Gln 1 5 10 15 Gly <210> 17 <211> 11 <212> PRT <213> Secuencia Artificial <220> <223> Cadena pesada CDR3 <400> 17 Gly Gly Thr Gly Thr Met Ala Trp Phe Ala Tyr 1 5 10 <210> 18 <211> 11 <212> PRT <213> Secuencia Artificial <220> <223> Cadena pesada CDR3 <400> 18 Gly Gly Thr Gly Thr Leu Ala Trp Phe Ala Tyr 1 5 10 <210> 19 <211> 11 <212> PRT <213> Secuencia Artificial <220> <223> Cadena pesada CDR3 <400> 19 Gly Gly Thr Gly Thr Met Ala Tyr Phe Ala Tyr 1 5 10 <210> 20 <211> 11 <212> PRT <213> Secuencia Artificial <220> <223> Cadena pesada CDR3 <400> 20 Gly Gly Thr Gly Thr Leu Ala Tyr Phe Ala Tyr 1 5 10 <210> 21 <211> 16 <212> PRT <213> Secuencia Artificial <220> <223> Cadena ligera CDR1 <400> 21 Arg Ser Ser Gln Ser Leu Val His Ser Tyr Gly Asn Thr Tyr Leu Tyr 1 5 10 15 <210> 22 <211> 7 <212> PRT <213> Secuencia Artificial <220> <223> Cadena ligera CDR2 <400> 22 Arg Val Ser Asn Arg Phe Ser 1 5 <210> 23 <211> 9 <212> PRT <213> Secuencia Artificial <220> <223> Cadena ligera CDR3 <400> 23 Phe Gln Gly Thr His Val Pro Tyr Thr 1 5 <210> 24 <211> 120 <212> PRT <213> Secuencia Artificial <220> <223> Dominio variable de cadena pesada <400> 24 Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ser 1 5 10 15 Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Trp Val His Trp Val Lys Gln Arg Pro Ile Gln Gly Leu Glu Trp Ile 35 40 45 Gly Asn Ile Asp Pro Ser Asp Ser Asp Thr His Tyr Asn Gln Lys Phe 50 55 60 Lys Asp Lys Ala Ser Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Gln Leu Ser Ser Leu Thr Phe Glu Asp Ser Ala Val Tyr Tyr Cys 85 90 95 Val Arg Gly Gly Thr Gly Thr Met Ala Trp Phe Ala Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ala 115 120 <210> 25 <211> 120 <212> PRT <213> Secuencia Artificial <220> <223> Dominio variable de cadena pesada <400> 25 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Trp Val His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Asn Ile Asp Pro Ser Asp Ser Asp Thr His Tyr Asn Gln Lys Phe 50 55 60 Lys Asp His Val Thr Leu Ser Val Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80 Leu Gln Leu Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Val Arg Gly Gly Thr Gly Thr Met Ala Trp Phe Ala Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 26 <211> 120 <212> PRT <213> Secuencia Artificial <220> <223> Dominio variable de cadena pesada <400> 26 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Arg Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 20 25 30 Trp Val His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Asn Ile Asp Pro Ser Asp Ser Asp Thr His Tyr Asn Gln Lys Phe 50 55 60 Lys Asp His Val Thr Leu Ser Val Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80 Leu Gln Leu Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Val Arg Gly Gly Thr Gly Thr Met Ala Trp Phe Ala Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 27 <211> 120 <212> PRT <213> Secuencia Artificial <220> <223> Dominio variable de cadena pesada <400> 27 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Arg Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 20 25 30 Trp Val His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Asn Ile Asp Pro Ser Asp Ser Asp Thr His Tyr Ser Pro Ser Phe 50 55 60 Gln Gly His Val Thr Leu Ser Val Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80 Leu Gln Leu Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Val Arg Gly Gly Thr Gly Thr Met Ala Trp Phe Ala Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 28 <211> 120 <212> PRT <213> Secuencia Artificial <220> <223> Dominio variable de cadena pesada <400> 28 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Arg Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 20 25 30 Trp Val His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Asn Ile Asp Pro Ser Asp Ser Asp Thr His Tyr Ser Pro Ser Phe 50 55 60 Gln Gly His Val Thr Leu Ser Val Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80 Leu Gln Leu Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Val Arg Gly Gly Thr Gly Thr Leu Ala Trp Phe Ala Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 29 <211> 120 <212> PRT <213> Secuencia Artificial <220> <223> Dominio variable de cadena pesada <400> 29 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Arg Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 20 25 30 Trp Val His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Asn Ile Asp Pro Ser Asp Ser Asp Thr His Tyr Ser Pro Ser Phe 50 55 60 Gln Gly His Val Thr Leu Ser Val Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80 Leu Gln Leu Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Val Arg Gly Gly Thr Gly Thr Met Ala Tyr Phe Ala Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 30 <211> 120 <212> PRT <213> Secuencia Artificial <220> <223> Dominio variable de cadena pesada <400> 30 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Arg Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 20 25 30 Trp Val His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Asn Ile Asp Pro Ser Asp Ser Asp Thr His Tyr Ser Pro Ser Phe 50 55 60 Gln Gly His Val Thr Leu Ser Val Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80 Leu Gln Leu Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Val Arg Gly Gly Thr Gly Thr Leu Ala Tyr Phe Ala Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 31 <211> 112 <212> PRT <213> Secuencia Artificial <220> <223> Dominio variable de cadena ligera <400> 31 Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 1 5 10 15 Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 20 25 30 Tyr Gly Asn Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Lys Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Phe Gln Gly 85 90 95 Thr His Val Pro Tyr Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 32 <211> 112 <212> PRT <213> Secuencia Artificial <220> <223> Dominio variable de cadena ligera <400> 32 Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 1 5 10 15 Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 20 25 30 Tyr Gly Asn Thr Tyr Leu Tyr Trp Tyr Gln Gln Arg Pro Gly Gln Ser 35 40 45 Pro Arg Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Phe Gln Gly 85 90 95 Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 33 <211> 112 <212> PRT <213> Secuencia Artificial <220> <223> Dominio variable de cadena ligera <400> 33 Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 1 5 10 15 Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 20 25 30 Tyr Gly Asn Thr Tyr Leu Tyr Trp Phe Gln Gln Arg Pro Gly Gln Ser 35 40 45 Pro Arg Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 85 90 95 Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 34 <211> 327 <212> PRT <213> Secuencia Artificial <220> <223> Dominio constante de cadena pesada-IgG4m-S228P <400> 34 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 1 5 10 15 Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 65 70 75 80 Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 100 105 110 Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 115 120 125 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 130 135 140 Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 145 150 155 160 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 165 170 175 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 180 185 190 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 195 200 205 Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 210 215 220 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 225 230 235 240 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 245 250 255 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 260 265 270 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 275 280 285 Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 290 295 300 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 305 310 315 320 Leu Ser Leu Ser Pro Gly Lys 325 <210> 35 <211> 107 <212> PRT <213> Secuencia Artificial <220> <223> Dominio constante de cadena ligera-CLkappa <400> 35 Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 1 5 10 15 Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 20 25 30 Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 35 40 45 Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 50 55 60 Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 65 70 75 80 Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 85 90 95 Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 100 105 <210> 36 <211> 447 <212> PRT <213> Secuencia Artificial <220> <223> Secuencia de cadena pesada 18D5 <400> 36 Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ser 1 5 10 15 Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Trp Val His Trp Val Lys Gln Arg Pro Ile Gln Gly Leu Glu Trp Ile 35 40 45 Gly Asn Ile Asp Pro Ser Asp Ser Asp Thr His Tyr Asn Gln Lys Phe 50 55 60 Lys Asp Lys Ala Ser Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Gln Leu Ser Ser Leu Thr Phe Glu Asp Ser Ala Val Tyr Tyr Cys 85 90 95 Val Arg Gly Gly Thr Gly Thr Met Ala Trp Phe Ala Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val 115 120 125 Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 130 135 140 Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 145 150 155 160 Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 165 170 175 Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 180 185 190 Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 195 200 205 Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 210 215 220 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 225 230 235 240 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 245 250 255 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 260 265 270 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 275 280 285 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 290 295 300 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 305 310 315 320 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 325 330 335 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 340 345 350 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 355 360 365 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 370 375 380 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 385 390 395 400 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 405 410 415 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 420 425 430 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 435 440 445 <210> 37 <211> 447 <212> PRT <213> Secuencia Artificial <220> <223> Secuencia de cadena pesada HA <400> 37 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Trp Val His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Asn Ile Asp Pro Ser Asp Ser Asp Thr His Tyr Asn Gln Lys Phe 50 55 60 Lys Asp His Val Thr Leu Ser Val Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80 Leu Gln Leu Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Val Arg Gly Gly Thr Gly Thr Met Ala Trp Phe Ala Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 115 120 125 Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 130 135 140 Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 145 150 155 160 Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 165 170 175 Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 180 185 190 Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 195 200 205 Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 210 215 220 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 225 230 235 240 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 245 250 255 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 260 265 270 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 275 280 285 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 290 295 300 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 305 310 315 320 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 325 330 335 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 340 345 350 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 355 360 365 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 370 375 380 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 385 390 395 400 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 405 410 415 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 420 425 430 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 435 440 445 <210> 38 <211> 447 <212> PRT <213> Secuencia Artificial <220> <223> Secuencia de cadena pesada HB <400> 38 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Arg Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 20 25 30 Trp Val His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Asn Ile Asp Pro Ser Asp Ser Asp Thr His Tyr Asn Gln Lys Phe 50 55 60 Lys Asp His Val Thr Leu Ser Val Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80 Leu Gln Leu Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Val Arg Gly Gly Thr Gly Thr Met Ala Trp Phe Ala Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 115 120 125 Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 130 135 140 Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 145 150 155 160 Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 165 170 175 Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 180 185 190 Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 195 200 205 Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 210 215 220 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 225 230 235 240 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 245 250 255 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 260 265 270 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 275 280 285 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 290 295 300 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 305 310 315 320 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 325 330 335 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 340 345 350 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 355 360 365 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 370 375 380 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 385 390 395 400 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 405 410 415 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 420 425 430 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 435 440 445 <210> 39 <211> 447 <212> PRT <213> Secuencia Artificial <220> <223> Secuencia de cadena pesada HC <400> 39 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Arg Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 20 25 30 Trp Val His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Asn Ile Asp Pro Ser Asp Ser Asp Thr His Tyr Ser Pro Ser Phe 50 55 60 Gln Gly His Val Thr Leu Ser Val Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80 Leu Gln Leu Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Val Arg Gly Gly Thr Gly Thr Met Ala Trp Phe Ala Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 115 120 125 Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 130 135 140 Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 145 150 155 160 Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 165 170 175 Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 180 185 190 Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 195 200 205 Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 210 215 220 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 225 230 235 240 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 245 250 255 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 260 265 270 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 275 280 285 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 290 295 300 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 305 310 315 320 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 325 330 335 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 340 345 350 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 355 360 365 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 370 375 380 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 385 390 395 400 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 405 410 415 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 420 425 430 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 435 440 445 <210> 40 <211> 447 <212> PRT <213> Secuencia Artificial <220> <223> Secuencia de cadena pesada HE <400> 40 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Arg Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 20 25 30 Trp Val His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Asn Ile Asp Pro Ser Asp Ser Asp Thr His Tyr Ser Pro Ser Phe 50 55 60 Gln Gly His Val Thr Leu Ser Val Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80 Leu Gln Leu Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Val Arg Gly Gly Thr Gly Thr Leu Ala Trp Phe Ala Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 115 120 125 Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 130 135 140 Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 145 150 155 160 Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 165 170 175 Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 180 185 190 Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 195 200 205 Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 210 215 220 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 225 230 235 240 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 245 250 255 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 260 265 270 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 275 280 285 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 290 295 300 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 305 310 315 320 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 325 330 335 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 340 345 350 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 355 360 365 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 370 375 380 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 385 390 395 400 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 405 410 415 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 420 425 430 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 435 440 445 <210> 41 <211> 447 <212> PRT <213> Secuencia Artificial <220> <223> Secuencia de cadena pesada HF <400> 41 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Arg Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 20 25 30 Trp Val His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Asn Ile Asp Pro Ser Asp Ser Asp Thr His Tyr Ser Pro Ser Phe 50 55 60 Gln Gly His Val Thr Leu Ser Val Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80 Leu Gln Leu Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Val Arg Gly Gly Thr Gly Thr Met Ala Tyr Phe Ala Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 115 120 125 Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 130 135 140 Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 145 150 155 160 Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 165 170 175 Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 180 185 190 Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 195 200 205 Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 210 215 220 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 225 230 235 240 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 245 250 255 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 260 265 270 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 275 280 285 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 290 295 300 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 305 310 315 320 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 325 330 335 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 340 345 350 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 355 360 365 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 370 375 380 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 385 390 395 400 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 405 410 415 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 420 425 430 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 435 440 445 <210> 42 <211> 447 <212> PRT <213> Secuencia Artificial <220> <223> Secuencia de cadena pesada HEF <400> 42 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Arg Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 20 25 30 Trp Val His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Asn Ile Asp Pro Ser Asp Ser Asp Thr His Tyr Ser Pro Ser Phe 50 55 60 Gln Gly His Val Thr Leu Ser Val Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80 Leu Gln Leu Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Val Arg Gly Gly Thr Gly Thr Leu Ala Tyr Phe Ala Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 115 120 125 Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 130 135 140 Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 145 150 155 160 Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 165 170 175 Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 180 185 190 Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 195 200 205 Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 210 215 220 Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 225 230 235 240 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 245 250 255 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 260 265 270 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 275 280 285 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 290 295 300 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 305 310 315 320 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 325 330 335 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 340 345 350 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 355 360 365 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 370 375 380 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 385 390 395 400 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 405 410 415 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 420 425 430 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 435 440 445 <210> 43 <211> 219 <212> PRT <213> Secuencia Artificial <220> <223> Secuencia de cadena ligera 18D5 <400> 43 Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 1 5 10 15 Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 20 25 30 Tyr Gly Asn Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Lys Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Phe Gln Gly 85 90 95 Thr His Val Pro Tyr Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 100 105 110 Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 115 120 125 Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 130 135 140 Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 145 150 155 160 Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 165 170 175 Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 180 185 190 Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 195 200 205 Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 210 215 <210> 44 <211> 219 <212> PRT <213> Secuencia Artificial <220> <223> Secuencia de cadena ligera LA <400> 44 Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 1 5 10 15 Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 20 25 30 Tyr Gly Asn Thr Tyr Leu Tyr Trp Tyr Gln Gln Arg Pro Gly Gln Ser 35 40 45 Pro Arg Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Phe Gln Gly 85 90 95 Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 115 120 125 Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 130 135 140 Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 145 150 155 160 Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 165 170 175 Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 180 185 190 Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 195 200 205 Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 210 215 <210> 45 <211> 219 <212> PRT <213> Secuencia Artificial <220> <223> Secuencia de cadena ligera LB <400> 45 Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 1 5 10 15 Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 20 25 30 Tyr Gly Asn Thr Tyr Leu Tyr Trp Phe Gln Gln Arg Pro Gly Gln Ser 35 40 45 Pro Arg Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 85 90 95 Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 115 120 125 Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 130 135 140 Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 145 150 155 160 Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 165 170 175 Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 180 185 190 Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 195 200 205 Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 210 215 <210> 46 <211> 360 <212> ADN <213> Secuencia Artificial <220> <223> Secuencia de ácido nucleico que codifica el dominio variable de cadena pesada 18D5 <400> 46 caggtgcagc tgcagcagcc aggagctgag ctggtgaggc ctggctccag cgtgaagctg 60 tcctgcaagg ctagcggcta caccttcaca agctattggg tgcactgggt gaagcagcgg 120 ccaatccagg gcctggagtg gatcggcaac atcgacccca gcgactctga tacccattac 180 aatcagaagt ttaaggacaa ggcctctctg accgtggata agtcttccag cacagcttat 240 atgcagctgt cttccctgac attcgaggat tccgccgtgt actattgcgt gaggggagga 300 accggaacaa tggcttggtt tgcttactgg ggccagggca ccctggtgac agtgtctgct 360 <210> 47 <211> 360 <212> ADN <213> Secuencia Artificial <220> <223> Secuencia de ácido nucleico que codifica el dominio variable de cadena pesada HA <400> 47 gaggtgcagc tggtgcagag cggagctgag gtgaagaagc caggcgagtc tctgaggatc 60 tcctgcaagg ctagcggcta caccttcaca tcttattggg tgcactgggt gcggcagatg 120 ccaggcaagg gcctggagtg gatcggcaac atcgacccta gcgactctga tacccactac 180 aatcagaagt ttaaggacca tgtgaccctg tctgtggata agtccatcag cacagcctat 240 ctgcagctgt ccagcctgaa ggcctccgat acagctatgt actattgcgt gaggggagga 300 accggaacaa tggcttggtt cgcttactgg ggccagggca ccctggtgac agtgtcttcc 360 <210> 48 <211> 360 <212> ADN <213> Secuencia Artificial <220> <223> Secuencia de ácido nucleico que codifica el dominio variable de cadena pesada HB <400> 48 gaggtgcagc tggtgcagtc cggagctgag gtgaagaagc caggcgagtc tctgaggatc 60 tcctgcaagg cttctggcta ctccttcacc agctattggg tgcactgggt gcggcagatg 120 ccaggcaagg gcctggagtg gatgggcaac atcgacccta gcgactctga tacacactac 180 aatcagaagt ttaaggacca tgtgaccctg agcgtggata agtccatcag cacagcctat 240 ctgcagctgt ccagcctgaa ggcctctgat accgctatgt actattgcgt gaggggagga 300 accggaacaa tggcttggtt cgcttactgg ggccagggca ccctggtgac agtgtcttcc 360 <210> 49 <211> 360 <212> ADN <213> Secuencia Artificial <220> <223> Secuencia de ácido nucleico que codifica el dominio variable de cadena pesada HC <400> 49 gaggtgcagc tggtgcagtc tggcgccgag gtgaagaagc caggcgagag cctgaggatc 60 tcttgcaagg ctagcggcta ctctttcacc tcctattggg tgcactgggt gcggcagatg 120 ccaggcaagg gcctggagtg gatgggcaac atcgacccca gcgactctga tacacactac 180 tcccctagct ttcagggcca tgtgaccctg tccgtggaca agtctatctc cacagcctat 240 ctgcagctgt ccagcctgaa ggccagcgat accgctatgt actattgcgt gaggggagga 300 accggaacaa tggcttggtt cgcttactgg ggccagggca ccctggtgac agtgtcttcc 360 <210> 50 <211> 360 <212> ADN <213> Secuencia Artificial <220> <223> Secuencia de ácido nucleico que codifica el dominio variable de cadena pesada HE <400> 50 gaggtgcagc tggtgcagtc tggcgccgag gtgaagaagc caggcgagag cctgaggatc 60 tcttgcaagg ctagcggcta ctctttcacc tcctattggg tgcactgggt gcggcagatg 120 ccaggcaagg gcctggagtg gatgggcaac atcgacccca gcgactctga tacacactac 180 tcccctagct ttcagggcca tgtgaccctg tccgtggaca agtctatctc cacagcctat 240 ctgcagctgt ccagcctgaa ggccagcgat accgctatgt actattgcgt gaggggagga 300 accggcacac tggcttggtt cgcttactgg ggccagggca ccctggtgac agtgtcttcc 360 <210> 51 <211> 360 <212> ADN <213> Secuencia Artificial <220> <223> Secuencia de ácido nucleico que codifica el dominio variable de cadena pesada HF <400> 51 gaggtgcagc tggtgcagtc tggcgccgag gtgaagaagc caggcgagag cctgaggatc 60 tcttgcaagg ctagcggcta ctctttcacc tcctattggg tgcactgggt gcggcagatg 120 ccaggcaagg gcctggagtg gatgggcaac atcgacccca gcgactctga tacacactac 180 tcccctagct ttcagggcca tgtgaccctg tccgtggaca agtctatctc cacagcctat 240 ctgcagctgt ccagcctgaa ggccagcgat accgctatgt actattgcgt gaggggagga 300 accggaacaa tggcttactt cgcttattgg ggccagggca ccctggtgac agtgtcttcc 360 <210> 52 <211> 360 <212> ADN <213> Secuencia Artificial <220> <223> Secuencia de ácido nucleico que codifica el dominio variable de cadena pesada HEF <400> 52 gaggtgcagc tggtgcagtc tggcgccgag gtgaagaagc caggcgagag cctgaggatc 60 tcttgcaagg ctagcggcta ctctttcacc tcctattggg tgcactgggt gcggcagatg 120 ccaggcaagg gcctggagtg gatgggcaac atcgacccca gcgactctga tacacactac 180 tcccctagct ttcagggcca tgtgaccctg tccgtggaca agtctatctc cacagcctat 240 ctgcagctgt ccagcctgaa ggccagcgat accgctatgt actattgcgt gaggggagga 300 accggcacac tggcttactt cgcttattgg ggccagggca ccctggtgac agtgtcttcc 360 <210> 53 <211> 336 <212> ADN <213> Secuencia Artificial <220> <223> Secuencia de ácido nucleico que codifica el dominio variable de cadena ligera 18D5 <400> 53 gacgtggtca tgacccagac accactgagc ctgcccgtgt ccctgggcga tcaggcctct 60 atctcctgca ggtccagcca gtccctggtg cacagctatg gcaacacata cctgtattgg 120 tacctgcaga agccaggcca gtcccccaag ctgctgatct acagggtgtc taatcggttc 180 tccggcgtgc ctgacaggtt ctccggctct ggctccggca ccgatttcac actgaagatc 240 agcagggtgg aggctgagga cctgggcgtg tatttctgtt ttcagggcac ccatgtgcca 300 tacacatttg gctctggcac caagctggag atcaag 336 <210> 54 <211> 336 <212> ADN <213> Secuencia Artificial <220> <223> Secuencia de ácido nucleico que codifica el dominio variable de cadena ligera LA <400> 54 gacgtggtca tgacacagag cccactgtct ctgcctgtga ccctgggaca gccagcctct 60 atctcctgca ggtccagcca gtccctggtg cacagctatg gcaacacata cctgtattgg 120 taccagcaga ggcccggaca gagcccaagg ctgctgatct acagggtgtc taatcggttc 180 tccggcgtgc ctgacaggtt tagcggctct ggctccggca ccgatttcac actgaagatc 240 tctagagtgg aggctgagga tgtgggcgtg tatttctgtt ttcagggcac ccatgtgcca 300 tacacatttg gcggcggcac caaggtggag atcaag 336 <210> 55 <211> 336 <212> ADN <213> Secuencia Artificial <220> <223> Secuencia de ácido nucleico que codifica el dominio variable de cadena ligera LB <400> 55 gacgtggtca tgacacagag cccactgtct ctgcctgtga ccctgggaca gccagcctct 60 atctcctgca ggtccagcca gtccctggtg cacagctacg gcaacacata cctgtattgg 120 ttccagcaga ggcccggaca gagcccaagg ctgctgatct atagggtgtc taatcggttc 180 tccggcgtgc ctgacaggtt tagcggatct ggatccggaa ccgacttcac cctgaagatc 240 tctagagtgg aggctgagga tgtgggcgtg tactattgtt tccagggcac ccatgtgcca 300 tacacatttg gcggcggcac caaggtggag atcaag 336 <210> 56 <211> 456 <212> PRT <213> Mus musculus <400> 56 Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ser 1 5 10 15 Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Trp Val His Trp Val Lys Gln Arg Pro Ile Gln Gly Leu Glu Trp Ile 35 40 45 Gly Asn Ile Asp Pro Ser Asp Ser Asp Thr His Tyr Asn Gln Lys Phe 50 55 60 Lys Asp Lys Ala Ser Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Gln Leu Ser Ser Leu Thr Phe Glu Asp Ser Ala Val Tyr Tyr Cys 85 90 95 Val Arg Gly Gly Thr Gly Thr Met Ala Trp Phe Ala Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ala Ala Lys Thr Thr Pro Pro Ser Val 115 120 125 Tyr Pro Leu Ala Pro Gly Cys Gly Asp Thr Thr Gly Ser Ser Val Thr 130 135 140 Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Ser Val Thr Val Thr 145 150 155 160 Trp Asn Ser Gly Ser Leu Ser Ser Ser Val His Thr Phe Pro Ala Leu 165 170 175 Leu Gln Ser Gly Leu Tyr Thr Met Ser Ser Ser Val Thr Val Pro Ser 180 185 190 Ser Thr Trp Pro Ser Gln Thr Val Thr Cys Ser Val Ala His Pro Ala 195 200 205 Ser Ser Thr Thr Val Asp Lys Lys Leu Glu Pro Ser Gly Pro Ile Ser 210 215 220 Thr Ile Asn Pro Cys Pro Pro Cys Lys Glu Cys His Lys Cys Pro Ala 225 230 235 240 Pro Asn Leu Glu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Asn Ile 245 250 255 Lys Asp Val Leu Met Ile Ser Leu Thr Pro Lys Val Thr Cys Val Val 260 265 270 Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val 275 280 285 Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp 290 295 300 Tyr Asn Ser Thr Ile Arg Val Val Ser Thr Leu Pro Ile Gln His Gln 305 310 315 320 Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp 325 330 335 Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ile Lys Gly Leu Val 340 345 350 Arg Ala Pro Gln Val Tyr Ile Leu Pro Pro Pro Ala Glu Gln Leu Ser 355 360 365 Arg Lys Asp Val Ser Leu Thr Cys Leu Val Val Gly Phe Asn Pro Gly 370 375 380 Asp Ile Ser Val Glu Trp Thr Ser Asn Gly His Thr Glu Glu Asn Tyr 385 390 395 400 Lys Asp Thr Ala Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Ile Tyr 405 410 415 Ser Lys Leu Asn Met Lys Thr Ser Lys Trp Glu Lys Thr Asp Ser Phe 420 425 430 Ser Cys Asn Val Arg His Glu Gly Leu Lys Asn Tyr Tyr Leu Lys Lys 435 440 445 Thr Ile Ser Arg Ser Pro Gly Lys 450 455 <210> 57 <211> 219 <212> PRT <213> Mus musculus <400> 57 Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 1 5 10 15 Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 20 25 30 Tyr Gly Asn Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Lys Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Phe Gln Gly 85 90 95 Thr His Val Pro Tyr Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 100 105 110 Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 115 120 125 Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 130 135 140 Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 145 150 155 160 Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 165 170 175 Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 180 185 190 Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 195 200 205 Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 210 215 <210> 58 <211> 15 <212> ADN <213> Secuencia Artificial <220> <223> Secuencia que codifica HCDR1 <400> 58 agctattggg tgcac 15 <210> 59 <211> 15 <212> ADN <213> Secuencia Artificial <220> <223> Secuencia que codifica HCDR1 <400> 59 tcttattggg tgcac 15 <210> 60 <211> 15 <212> ADN <213> Secuencia Artificial <220> <223> Secuencia que codifica HCDR1 <400> 60 tcctattggg tgcac 15 <210> 61 <211> 51 <212> ADN <213> Secuencia Artificial <220> <223> Secuencia que codifica HCDR2 <400> 61 aacatcgacc ccagcgactc tgatacccat tacaatcaga agtttaagga c 51 <210> 62 <211> 51 <212> ADN <213> Secuencia Artificial <220> <223> Secuencia que codifica HCDR2 <400> 62 aacatcgacc ccagcgactc tgatacacac tactccccta gctttcaggg c 51 <210> 63 <211> 33 <212> ADN <213> Secuencia Artificial <220> <223> Secuencia que codifica HCDR3 <400> 63 ggaggaaccg gaacaatggc ttggtttgct tac 33 <210> 64 <211> 33 <212> ADN <213> Secuencia Artificial <220> <223> Secuencia que codifica HCDR3 <400> 64 ggaggaaccg gcacactggc ttggttcgct tac 33 <210> 65 <211> 33 <212> ADN <213> Secuencia Artificial <220> <223> Secuencia que codifica HCDR3 <400> 65 ggaggaaccg gaacaatggc ttacttcgct tat 33 <210> 66 <211> 33 <212> ADN <213> Secuencia Artificial <220> <223> Secuencia que codifica HCDR3 <400> 66 ggaggaaccg gcacactggc ttacttcgct tat 33 <210> 67 <211> 48 <212> ADN <213> Secuencia Artificial <220> <223> Secuencia que codifica LCDR1 <400> 67 aggtccagcc agtccctggt gcacagctat ggcaacacat acctgtat 48 <210> 68 <211> 21 <212> ADN <213> Secuencia Artificial <220> <223> Secuencia que codifica LCDR2 <400> 68 agggtgtcta atcggttctc c 21 <210> 69 <211> 27 <212> ADN <213> Secuencia Artificial <220> <223> Secuencia que codifica LCDR3 <400> 69 tttcagggca cccatgtgcc atacaca 27 <210> 70 <211> 13 <212> PRT <213> Homo sapiens <400> 70 Glu Leu Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg 1 5 10 <210> 71 <211> 12 <212> PRT <213> Homo sapiens <400> 71 Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 1 5 10 <210> 72 <211> 9 <212> PRT <213> Homo sapiens <400> 72 Ser Pro Arg Asp Ile Thr Leu Lys Trp 1 5 <210> 73 <211> 4 <212> PRT <213> Homo sapiens <400> 73 Tyr Asn Gln Lys 1