LISTADO DE SECUENCIAS <110> BOSCH, IRENE HAMAD-SCHIFFERLI, KIMBERLY GEHRKE, LEE GOMEZ-MARQUEZ, JOSE DE PUIG, HELENE <120> ANTICUERPOS MONOCLONALES DE PROTEINA NS1 ANTI-VIRUS DEL DENGUE <130> 4041.3027 WO <140> PCT/US17/017385 <141> 2017-02-10 <150> 62/293,990 <151> 2016-02-11 <160> 37 <170> PatentIn version 3.5 <210> 1 <211> 17 <212> PRT <213> Dengue virus 4 <400> 1 Pro Val Asn Asp Leu Lys Tyr Ser Trp Lys Thr Trp Gly Lys Ala Lys 1 5 10 15 Ile <210> 2 <211> 17 <212> PRT <213> Dengue virus 3 <400> 2 Met Glu Leu Lys Tyr Ser Trp Lys Thr Trp Gly Leu Ala Lys Ile Val 1 5 10 15 Thr <210> 3 <211> 17 <212> PRT <213> Dengue virus 3 <400> 3 Gly Val Phe Thr Thr Asn Ile Trp Leu Lys Leu Arg Glu Val Tyr Thr 1 5 10 15 Gln <210> 4 <211> 17 <212> PRT <213> Dengue virus 3 <400> 4 Val Glu Asp Tyr Gly Phe Gly Val Phe Thr Thr Asn Ile Trp Leu Lys 1 5 10 15 Leu <210> 5 <211> 16 <212> PRT <213> Dengue virus 4 <400> 5 Gly Phe Gly Met Phe Thr Thr Asn Ile Trp Met Lys Phe Arg Glu Gly 1 5 10 15 <210> 6 <211> 16 <212> PRT <213> Dengue virus 4 <400> 6 Cys Arg Ser Cys Thr Met Pro Pro Leu Arg Phe Leu Gly Glu Asp Gly 1 5 10 15 <210> 7 <211> 17 <212> PRT <213> Dengue virus 4 <400> 7 Met Pro Pro Leu Arg Phe Leu Gly Glu Asp Gly Cys Trp Tyr Gly Met 1 5 10 15 Glu <210> 8 <211> 411 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 8 atgaaatgca gctgggttat cttcttcctg atggcagtgg ttacaggggt caattcagag 60 gttcagctgc atcagtctgg ggcagagctt gtgaagccag gggcctcagt caagttgtcc 120 tgcacagttt ctggcttcaa cattaaagac acctatattc actgggtgaa acagaggcct 180 gaacagggcc tggagtggat tggaaggatt gatcctgcaa atggtaatac tgaatatgac 240 ccgaagttcc agggcaaggc cactataaaa gccgacactt cctccaacac agcctacctg 300 caactcatca gtctgacatc tgaggacact gccgtctatt actgtgcttt ttattactac 360 ggtcgtagcc ttgcttactg gggccaaggg actctggtca ctgtctctgc a 411 <210> 9 <211> 137 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polypeptide <400> 9 Met Lys Cys Ser Trp Val Ile Phe Phe Leu Met Ala Val Val Thr Gly 1 5 10 15 Val Asn Ser Glu Val Gln Leu His Gln Ser Gly Ala Glu Leu Val Lys 20 25 30 Pro Gly Ala Ser Val Lys Leu Ser Cys Thr Val Ser Gly Phe Asn Ile 35 40 45 Lys Asp Thr Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu 50 55 60 Glu Trp Ile Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Glu Tyr Asp 65 70 75 80 Pro Lys Phe Gln Gly Lys Ala Thr Ile Lys Ala Asp Thr Ser Ser Asn 85 90 95 Thr Ala Tyr Leu Gln Leu Ile Ser Leu Thr Ser Glu Asp Thr Ala Val 100 105 110 Tyr Tyr Cys Ala Phe Tyr Tyr Tyr Gly Arg Ser Leu Ala Tyr Trp Gly 115 120 125 Gln Gly Thr Leu Val Thr Val Ser Ala 130 135 <210> 10 <211> 381 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 10 atgagtgtgc ccactcaggt cctggggttg ctgctgctgt ggcttacaga tgccagatgt 60 gacatccaga tgactcagtc tccagcctcc ctatctgtgt ctgtgggaga aactgtcacc 120 atcacatgtc gaacaagtga gaatatttac agtagtttag catggtatca gcagaaacag 180 ggaaaatctc ctcagctcct ggtctatgct gcagctaact tagcggatgg tgtgccatca 240 aggttcagtg gcagtggatc aggcacacag tattccctca agatcaacag cctgcagtct 300 gaagattttg gaacttatta ctgtcaacat ttttggggta ctccgtggac gttcggtgga 360 ggcaccaagc tggaaatcaa a 381 <210> 11 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polypeptide <400> 11 Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 1 5 10 15 Asp Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser 20 25 30 Val Ser Val Gly Glu Thr Val Thr Ile Thr Cys Arg Thr Ser Glu Asn 35 40 45 Ile Tyr Ser Ser Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro 50 55 60 Gln Leu Leu Val Tyr Ala Ala Ala Asn Leu Ala Asp Gly Val Pro Ser 65 70 75 80 Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn 85 90 95 Ser Leu Gln Ser Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His Phe Trp 100 105 110 Gly Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 115 120 125 <210> 12 <211> 408 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 12 atgaaatgca gctgggtcat cttcttcctg atggcagtgg ttacaggggt caattcagag 60 gttcagctgc agcagtctgg ggctgagctt gtgaggccag gggccttagt caagttgtcc 120 tgcagagctt ctggcttcag aattagagac tactatatac actgggtgaa gcagaggcct 180 gaacagggcc tggagtggat tggatggatt gatcctgagt atggtaatac tatttatgac 240 ccgaacttcc ggggcaaggc cagtataaca tcagacacat cctccaacac agcctacctg 300 cagctcagca gcctgtcttc tgaggacaca gccgtctatt actgtgcctc gtattattac 360 ggtggtgtga actactgggg ccaaggcacc actctcacag tctcctca 408 <210> 13 <211> 136 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polypeptide <400> 13 Met Lys Cys Ser Trp Val Ile Phe Phe Leu Met Ala Val Val Thr Gly 1 5 10 15 Val Asn Ser Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg 20 25 30 Pro Gly Ala Leu Val Lys Leu Ser Cys Arg Ala Ser Gly Phe Arg Ile 35 40 45 Arg Asp Tyr Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu 50 55 60 Glu Trp Ile Gly Trp Ile Asp Pro Glu Tyr Gly Asn Thr Ile Tyr Asp 65 70 75 80 Pro Asn Phe Arg Gly Lys Ala Ser Ile Thr Ser Asp Thr Ser Ser Asn 85 90 95 Thr Ala Tyr Leu Gln Leu Ser Ser Leu Ser Ser Glu Asp Thr Ala Val 100 105 110 Tyr Tyr Cys Ala Ser Tyr Tyr Tyr Gly Gly Val Asn Tyr Trp Gly Gln 115 120 125 Gly Thr Thr Leu Thr Val Ser Ser 130 135 <210> 14 <211> 384 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 14 atggattttc aagtgcagat tttcagcttc ctgctaatca gtgcctcagt catactgtcc 60 agaggacaaa ttgttctcac ccagtctcca gcaatcatgt ctgcatctcc aggggagaag 120 gtcaccatga cctgcagtgc cagttcaagt gtaagtcgca tttactggta ccaggagaag 180 ccaggatcct cccccagact cctgatttat gacacatcca acctggcttc tggagtccct 240 gttcgcttca gtggcagtgg gtctgggacc tcttactctc tcacaatcag ccgaatggag 300 gctgaagatg ctgccactta ttactgccag cagtggagta gttacccacg gacgttcggt 360 ggaggcacca agctggaaat caaa 384 <210> 15 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polypeptide <400> 15 Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 1 5 10 15 Val Ile Leu Ser Arg Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Ile 20 25 30 Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser 35 40 45 Ser Ser Val Ser Arg Ile Tyr Trp Tyr Gln Glu Lys Pro Gly Ser Ser 50 55 60 Pro Arg Leu Leu Ile Tyr Asp Thr Ser Asn Leu Ala Ser Gly Val Pro 65 70 75 80 Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 85 90 95 Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 100 105 110 Ser Ser Tyr Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 115 120 125 <210> 16 <211> 390 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 16 atggaatgta actggatact tccttttatt ctgtcagtaa cttcaggtgt ctactcacag 60 gtgcagctcc agcagtctgg gactgagctg gcaagacctg gggcttcagt gaaattgtcc 120 tgtaaggctt ctggctacac ctttactaat tactggatac agtgggtaaa acagaggcct 180 ggacagggtc tggaatggat tggggatatt tatcctggag atggtgatac taggtacact 240 cagaagttca ggggcaaggc catattgact gcagataaat cctccagcac agcctatatg 300 gaactcagca gtttggcatc tgaggactct gcggtctatt actgtgcctc actaacctgg 360 ggccaaggca ccactctcac agtctccaca 390 <210> 17 <211> 130 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polypeptide <400> 17 Met Glu Cys Asn Trp Ile Leu Pro Phe Ile Leu Ser Val Thr Ser Gly 1 5 10 15 Val Tyr Ser Gln Val Gln Leu Gln Gln Ser Gly Thr Glu Leu Ala Arg 20 25 30 Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 35 40 45 Thr Asn Tyr Trp Ile Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 50 55 60 Glu Trp Ile Gly Asp Ile Tyr Pro Gly Asp Gly Asp Thr Arg Tyr Thr 65 70 75 80 Gln Lys Phe Arg Gly Lys Ala Ile Leu Thr Ala Asp Lys Ser Ser Ser 85 90 95 Thr Ala Tyr Met Glu Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val 100 105 110 Tyr Tyr Cys Ala Ser Leu Thr Trp Gly Gln Gly Thr Thr Leu Thr Val 115 120 125 Ser Thr 130 <210> 18 <211> 399 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 18 atggaatcac agactcaggt cctcatgtcc ctgctgttct gggtatctgg tacctgtggg 60 gacattgtga tgacacagtc tccatcctcc ctgactgtga cagcaggaga gaaggtcact 120 atgagctgca ggtccagtca gagtctgtta aacagtggaa atcaaaagaa ctacttgacc 180 tggtaccagc agagaccagg gcagcctcct aaactgctga tctactgggc atccactagg 240 gaatctgggg tccctgatcg cttcacaggc agtggatctg gaacagattt cattctcacc 300 atcagcagtg tgcaggctga agacctggca gtttattact gtcagaatga gtatagttat 360 ccgctcacgt tcggtgctgg gaccaagctg gagctgaaa 399 <210> 19 <211> 133 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polypeptide <400> 19 Met Glu Ser Gln Thr Gln Val Leu Met Ser Leu Leu Phe Trp Val Ser 1 5 10 15 Gly Thr Cys Gly Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr 20 25 30 Val Thr Ala Gly Glu Lys Val Thr Met Ser Cys Arg Ser Ser Gln Ser 35 40 45 Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln 50 55 60 Arg Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 65 70 75 80 Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 85 90 95 Phe Ile Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr 100 105 110 Tyr Cys Gln Asn Glu Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr 115 120 125 Lys Leu Glu Leu Lys 130 <210> 20 <211> 408 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 20 atgaaatgca gctgggtcat cttcttcctg atggcagtgg ttacaggggt caactcagag 60 gttcagctgc agcagtctgg ggctgagttt atgaggccag gggccttagt caagttgtcc 120 tgcaaagctt ctggcttcaa cattaaagac tactatatgc attgggtgaa acagaggcct 180 gaacagggcc tggagtggat tggatggatt gaccctgaga atggtaatac tatatatgac 240 ccgaagttcc agggcaaggc cagtataaca gcagacacat cctccaacac agcctacctg 300 cagctcagca gcctgacttc tgaggacact gccgtctatt actgtgcctc gtattactac 360 ggtggtgtga actactgggg ccaaggcacc actctcacag tctcctca 408 <210> 21 <211> 136 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polypeptide <400> 21 Met Lys Cys Ser Trp Val Ile Phe Phe Leu Met Ala Val Val Thr Gly 1 5 10 15 Val Asn Ser Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Phe Met Arg 20 25 30 Pro Gly Ala Leu Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Asn Ile 35 40 45 Lys Asp Tyr Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu 50 55 60 Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly Asn Thr Ile Tyr Asp 65 70 75 80 Pro Lys Phe Gln Gly Lys Ala Ser Ile Thr Ala Asp Thr Ser Ser Asn 85 90 95 Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val 100 105 110 Tyr Tyr Cys Ala Ser Tyr Tyr Tyr Gly Gly Val Asn Tyr Trp Gly Gln 115 120 125 Gly Thr Thr Leu Thr Val Ser Ser 130 135 <210> 22 <211> 384 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 22 atggattttc aagtgcagat tttcagcttc ctgctaatca gtgcctcagt cattctgtcc 60 agaggacaaa ttgttctcac ccagtctcca gcaatcatgt ctgcatctcc aggggagaag 120 gtcaccatga cctgcagtgc cagctcaact gtaagttcca tttactggtt ccagcagagg 180 ccaggatcct cccccagact cctgatttat gacacatcca aactggcttc tggagtccct 240 attcgcttca ctggcagtgg gtctgggacc tcttactctc tcacaatcag ccgaatgggg 300 gctgaagatg ctgccactta ttactgccag cagtggagta gttacccacg gacgttcggt 360 ggaggcacca agctggaaat caaa 384 <210> 23 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polypeptide <400> 23 Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 1 5 10 15 Val Ile Leu Ser Arg Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Ile 20 25 30 Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser 35 40 45 Ser Thr Val Ser Ser Ile Tyr Trp Phe Gln Gln Arg Pro Gly Ser Ser 50 55 60 Pro Arg Leu Leu Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 65 70 75 80 Ile Arg Phe Thr Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 85 90 95 Ser Arg Met Gly Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 100 105 110 Ser Ser Tyr Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 115 120 125 <210> 24 <211> 414 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 24 atggctgtcc tggtgctgtt cctctgcctg gttgcatttc caagctgtgt cctgtcccag 60 gtgcagctga aggagtcagg acctggcctg gtggcgccct cacagagcct gtccatcact 120 tgcactgtct ctgggttttc attaaccagc tatggtgtac actgggttcg ccagcctcca 180 ggaaagggtc tggagtggct gggagtaata tggcctggtg gaagcacaaa ttataattcg 240 gctctcatgt ccagactgag catcagcaaa gacagttcca agagccaagt tttcttaaaa 300 atgaacagtc tgcaacctga tgacacagcc atatactact gtgccagaga gccgatctac 360 ggtagtaggt acttcgatgt ctggggcgca gggaccacgg tcaccgtctc ctca 414 <210> 25 <211> 138 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polypeptide <400> 25 Met Ala Val Leu Val Leu Phe Leu Cys Leu Val Ala Phe Pro Ser Cys 1 5 10 15 Val Leu Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala 20 25 30 Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 35 40 45 Thr Ser Tyr Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 50 55 60 Glu Trp Leu Gly Val Ile Trp Pro Gly Gly Ser Thr Asn Tyr Asn Ser 65 70 75 80 Ala Leu Met Ser Arg Leu Ser Ile Ser Lys Asp Ser Ser Lys Ser Gln 85 90 95 Val Phe Leu Lys Met Asn Ser Leu Gln Pro Asp Asp Thr Ala Ile Tyr 100 105 110 Tyr Cys Ala Arg Glu Pro Ile Tyr Gly Ser Arg Tyr Phe Asp Val Trp 115 120 125 Gly Ala Gly Thr Thr Val Thr Val Ser Ser 130 135 <210> 26 <211> 381 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 26 atggtatcca cacctcagtt ccttgtattt ttgcttttct ggattccagc ctccagaggt 60 gacatcctgc tgactcagtc tccagccatc ctgtctgtga gtccaggaga aagagtcact 120 ctctcctgca gggccagtca gagcattggc acaagaatac actggtatca gcaaagaaca 180 aatggttctc caaggcttct cataaagttt gcttttgagt ctatctctgg gatcccttcc 240 aggtttagtg gcagtggatc agggacagat tttactctta gcatcaacag tgtggagtct 300 gaagatattg cagagtatta ctgtcaacag agtattaact ggccgctcac gttcggtgct 360 gggaccaagc tggaactgaa a 381 <210> 27 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polypeptide <400> 27 Met Val Ser Thr Pro Gln Phe Leu Val Phe Leu Leu Phe Trp Ile Pro 1 5 10 15 Ala Ser Arg Gly Asp Ile Leu Leu Thr Gln Ser Pro Ala Ile Leu Ser 20 25 30 Val Ser Pro Gly Glu Arg Val Thr Leu Ser Cys Arg Ala Ser Gln Ser 35 40 45 Ile Gly Thr Arg Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro 50 55 60 Arg Leu Leu Ile Lys Phe Ala Phe Glu Ser Ile Ser Gly Ile Pro Ser 65 70 75 80 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn 85 90 95 Ser Val Glu Ser Glu Asp Ile Ala Glu Tyr Tyr Cys Gln Gln Ser Ile 100 105 110 Asn Trp Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 115 120 125 <210> 28 <211> 16 <212> PRT <213> Dengue virus 2 <400> 28 Thr Glu Leu Lys Tyr Ser Trp Lys Thr Trp Gly Lys Ala Lys Met Leu 1 5 10 15 <210> 29 <211> 353 <212> PRT <213> Dengue virus 1 <400> 29 Asp Ser Gly Cys Val Ile Asn Trp Lys Gly Arg Glu Leu Lys Cys Gly 1 5 10 15 Ser Gly Ile Phe Val Thr Asn Glu Val His Thr Trp Thr Glu Gln Tyr 20 25 30 Lys Phe Gln Ala Asp Ser Pro Lys Arg Leu Ser Ala Ala Ile Gly Lys 35 40 45 Ala Trp Glu Glu Gly Val Cys Gly Ile Arg Ser Ala Thr Arg Leu Glu 50 55 60 Asn Ile Met Trp Lys Gln Ile Ser Asn Glu Leu Asn His Ile Leu Leu 65 70 75 80 Glu Asn Asp Met Lys Phe Thr Val Val Val Gly Asp Val Val Gly Ile 85 90 95 Leu Ala Gln Gly Lys Lys Met Ile Arg Pro Gln Pro Met Glu His Lys 100 105 110 Tyr Ser Trp Lys Ser Trp Gly Lys Ala Lys Ile Ile Gly Ala Asp Ile 115 120 125 Gln Asn Thr Thr Phe Ile Ile Asp Gly Pro Asp Thr Pro Glu Cys Pro 130 135 140 Asp Asp Gln Arg Ala Trp Asn Ile Trp Glu Val Glu Asp Tyr Gly Phe 145 150 155 160 Gly Ile Phe Thr Thr Asn Ile Trp Leu Lys Leu Arg Asp Ser Tyr Thr 165 170 175 Gln Met Cys Asp His Arg Leu Met Ser Ala Ala Ile Lys Asp Ser Lys 180 185 190 Ala Val His Ala Asp Met Gly Tyr Trp Ile Glu Ser Glu Lys Asn Glu 195 200 205 Thr Trp Lys Leu Ala Arg Ala Ser Phe Ile Glu Val Lys Thr Cys Val 210 215 220 Trp Pro Lys Ser His Thr Leu Trp Ser Asn Gly Val Leu Glu Ser Glu 225 230 235 240 Met Ile Ile Pro Lys Ile Tyr Gly Gly Pro Ile Ser Gln His Asn Tyr 245 250 255 Arg Pro Gly Tyr Phe Thr Gln Thr Ala Gly Pro Trp His Leu Gly Lys 260 265 270 Leu Glu Leu Asp Phe Asp Leu Cys Glu Gly Thr Thr Val Val Val Asp 275 280 285 Glu His Cys Gly Asn Arg Gly Pro Ser Leu Arg Thr Thr Thr Val Thr 290 295 300 Gly Lys Ile Ile His Glu Trp Cys Cys Arg Ser Cys Thr Leu Pro Pro 305 310 315 320 Leu Arg Phe Lys Gly Glu Asp Gly Cys Trp Tyr Gly Met Glu Ile Arg 325 330 335 Pro Val Lys Glu Lys Glu Glu Asn Leu Val Lys Ser Met Val Ser Ala 340 345 350 Gly <210> 30 <211> 357 <212> PRT <213> Dengue virus 2 <400> 30 Val Met Val Gln Ala Asp Ser Gly Cys Val Val Ser Trp Lys Asn Lys 1 5 10 15 Glu Leu Lys Cys Gly Ser Gly Ile Phe Ile Thr Asp Asn Val His Thr 20 25 30 Trp Thr Glu Gln Tyr Lys Phe Gln Pro Glu Ser Pro Ser Lys Leu Ala 35 40 45 Ser Ala Ile Gln Lys Ala His Glu Glu Gly Ile Cys Gly Ile Arg Ser 50 55 60 Val Thr Arg Leu Glu Asn Leu Met Trp Lys Gln Ile Thr Pro Glu Leu 65 70 75 80 Asn His Ile Leu Ser Glu Asn Glu Val Lys Leu Thr Ile Met Thr Gly 85 90 95 Asp Ile Lys Gly Ile Met Gln Ala Gly Lys Arg Ser Leu Gln Pro Gln 100 105 110 Pro Thr Glu Leu Lys Tyr Ser Trp Lys Thr Trp Gly Lys Ala Lys Met 115 120 125 Leu Ser Thr Glu Ser His Asn Gln Thr Phe Leu Ile Asp Gly Pro Glu 130 135 140 Thr Ala Glu Cys Pro Asn Thr Asn Arg Ala Trp Asn Ser Leu Glu Val 145 150 155 160 Glu Asp Tyr Gly Phe Gly Val Phe Thr Thr Asn Ile Trp Leu Lys Leu 165 170 175 Arg Glu Lys Gln Asp Val Phe Cys Asp Ser Lys Leu Met Ser Ala Ala 180 185 190 Ile Lys Asp Asn Arg Ala Val His Ala Asp Met Gly Tyr Trp Ile Glu 195 200 205 Ser Ala Leu Asn Asp Thr Trp Lys Ile Glu Lys Ala Ser Phe Ile Glu 210 215 220 Val Lys Ser Cys His Trp Pro Lys Ser His Thr Leu Trp Ser Asn Gly 225 230 235 240 Val Leu Glu Ser Glu Met Ile Ile Pro Lys Asn Phe Ala Gly Pro Val 245 250 255 Ser Gln His Asn Tyr Arg Pro Gly Tyr His Thr Gln Thr Ala Gly Pro 260 265 270 Trp His Leu Gly Lys Leu Glu Met Asp Phe Asp Phe Cys Glu Gly Thr 275 280 285 Thr Val Val Val Thr Glu Asp Cys Gly Asn Arg Gly Pro Ser Leu Arg 290 295 300 Thr Thr Thr Ala Ser Gly Lys Leu Ile Thr Glu Trp Cys Cys Arg Ser 305 310 315 320 Cys Thr Leu Pro Pro Leu Arg Tyr Arg Gly Glu Asp Gly Cys Trp Tyr 325 330 335 Gly Met Glu Ile Arg Pro Leu Lys Glu Lys Glu Glu Asn Leu Val Asn 340 345 350 Ser Leu Val Thr Ala 355 <210> 31 <211> 353 <212> PRT <213> Dengue virus 3 <400> 31 Asp Met Gly Cys Val Ile Asn Trp Lys Gly Lys Glu Leu Lys Cys Gly 1 5 10 15 Ser Gly Ile Phe Val Thr Asn Glu Val His Thr Trp Thr Glu Gln Tyr 20 25 30 Lys Phe Gln Ala Asp Ser Pro Lys Arg Val Ala Thr Ala Ile Ala Gly 35 40 45 Ala Trp Glu Asn Gly Val Cys Gly Ile Arg Ser Thr Thr Arg Met Glu 50 55 60 Asn Leu Leu Trp Lys Gln Ile Ala Asn Glu Leu Asn Tyr Ile Leu Trp 65 70 75 80 Glu Asn Asp Ile Lys Leu Thr Val Val Val Gly Asp Ile Thr Gly Val 85 90 95 Leu Glu Gln Gly Lys Arg Thr Leu Thr Pro Gln Pro Met Glu Leu Lys 100 105 110 Tyr Ser Trp Lys Thr Trp Gly Leu Ala Lys Ile Val Thr Ala Glu Thr 115 120 125 Gln Asn Ser Ser Phe Ile Ile Asp Gly Pro Ser Thr Pro Glu Cys Pro 130 135 140 Ser Ala Ser Arg Ala Trp Asn Val Trp Glu Val Glu Asp Tyr Gly Phe 145 150 155 160 Gly Val Phe Thr Thr Asn Ile Trp Leu Lys Leu Arg Glu Val Tyr Thr 165 170 175 Gln Leu Cys Asp His Arg Leu Met Ser Ala Ala Val Lys Asp Glu Arg 180 185 190 Ala Val His Ala Asp Met Gly Tyr Trp Ile Glu Ser Gln Lys Asn Gly 195 200 205 Ser Trp Lys Leu Glu Lys Ala Ser Leu Ile Glu Val Lys Thr Cys Thr 210 215 220 Trp Pro Lys Ser His Thr Leu Trp Ser Asn Gly Val Leu Glu Ser Asp 225 230 235 240 Met Ile Ile Pro Lys Ser Leu Ala Gly Pro Ile Ser Gln His Asn His 245 250 255 Arg Pro Gly Tyr His Thr Gln Thr Ala Gly Pro Trp His Leu Gly Lys 260 265 270 Leu Glu Leu Asp Phe Asn Tyr Cys Glu Gly Thr Thr Val Val Ile Ser 275 280 285 Glu Asn Cys Gly Thr Arg Gly Pro Ser Leu Arg Thr Thr Thr Val Ser 290 295 300 Gly Lys Leu Ile His Glu Trp Cys Cys Arg Ser Cys Thr Leu Pro Pro 305 310 315 320 Leu Arg Tyr Met Gly Glu Asp Gly Cys Trp Tyr Gly Met Glu Ile Arg 325 330 335 Pro Ile Asn Glu Lys Glu Glu Asn Met Val Lys Ser Leu Ala Ser Ala 340 345 350 Gly <210> 32 <211> 353 <212> PRT <213> Dengue virus 4 <400> 32 Asp Met Gly Cys Val Val Ser Trp Ser Gly Lys Glu Leu Lys Cys Gly 1 5 10 15 Ser Gly Ile Phe Val Ala Asp Asn Val His Thr Trp Thr Glu Gln Tyr 20 25 30 Lys Phe Gln Pro Glu Ser Pro Ala Arg Leu Ala Ser Ala Ile Leu Asn 35 40 45 Ala His Lys Asp Gly Val Cys Gly Ile Arg Ser Thr Thr Arg Leu Glu 50 55 60 Asn Val Met Trp Lys Gln Ile Thr Asn Glu Leu Asn Tyr Val Leu Trp 65 70 75 80 Glu Gly Gly His Asp Leu Thr Val Val Ala Gly Asp Val Lys Gly Val 85 90 95 Leu Thr Lys Gly Lys Arg Ala Leu Thr Pro Pro Val Asn Asp Leu Lys 100 105 110 Tyr Ser Trp Lys Thr Trp Gly Lys Ala Lys Ile Phe Thr Pro Glu Ala 115 120 125 Arg Asn Ser Thr Phe Leu Ile Asp Gly Pro Asp Thr Ser Glu Cys Pro 130 135 140 Asn Glu Arg Arg Ala Trp Asn Phe Leu Glu Val Glu Asp Tyr Gly Phe 145 150 155 160 Gly Met Phe Thr Thr Asn Ile Trp Met Lys Phe Arg Glu Gly Ser Ser 165 170 175 Glu Val Cys Asp His Arg Leu Met Ser Ala Ala Ile Lys Asp Gln Lys 180 185 190 Ala Val His Ala Asp Met Gly Tyr Trp Ile Glu Ser Ser Lys Asn Gln 195 200 205 Thr Trp Gln Ile Glu Lys Ala Ser Leu Ile Glu Val Lys Thr Cys Leu 210 215 220 Trp Pro Lys Thr His Thr Leu Trp Ser Asn Gly Val Leu Glu Ser Gln 225 230 235 240 Met Leu Ile Pro Lys Ser Tyr Ala Gly Pro Phe Ser Gln His Asn Tyr 245 250 255 Arg Gln Gly Tyr Ala Thr Gln Thr Val Gly Pro Trp His Leu Gly Lys 260 265 270 Leu Glu Ile Asp Phe Gly Glu Cys Pro Gly Thr Thr Val Thr Ile Gln 275 280 285 Glu Asp Cys Asp His Arg Gly Pro Ser Leu Arg Thr Thr Thr Ala Ser 290 295 300 Gly Lys Leu Val Thr Gln Trp Cys Cys Arg Ser Cys Thr Met Pro Pro 305 310 315 320 Leu Arg Phe Leu Gly Glu Asp Gly Cys Trp Tyr Gly Met Glu Ile Arg 325 330 335 Pro Leu Ser Glu Lys Glu Glu Asn Met Val Lys Ser Gln Val Thr Ala 340 345 350 Gly <210> 33 <211> 11 <212> PRT <213> Dengue virus 1 <400> 33 Tyr Gly Gly Pro Ile Ser Gln His Asn Tyr Arg 1 5 10 <210> 34 <211> 15 <212> PRT <213> Dengue virus 1 <400> 34 Met Ile Arg Pro Gln Pro Met Glu His Lys Tyr Ser Trp Lys Ser 1 5 10 15 <210> 35 <211> 15 <212> PRT <213> Dengue virus 1 <400> 35 His Lys Tyr Ser Trp Lys Ser Trp Gly Lys Ala Lys Ile Ile Gly 1 5 10 15 <210> 36 <211> 10 <212> PRT <213> Dengue virus 2 <400> 36 Gly Gly Pro Val Ser Gln His Asn Tyr Arg 1 5 10 <210> 37 <211> 15 <212> PRT <213> Dengue virus 1 <400> 37 Ile Trp Leu Lys Leu Arg Asp Ser Tyr Thr Gln Met Cys Asp His 1 5 10 15