SEQUENCE LISTING <110> Regeneron Pharmaceuticals, Inc. <120> A Method of Averting Opioid Addiction <130> REGN-025WO <140> TBA (Filed Herewith) <141> 2017-11-28 <150> 62/427,365 <151> 2016-11-29 <160> 18 <170> FastSEQ for Windows Version 4.0 <210> 1 <211> 357 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1 caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc 60 tcctgcaagg tttccggatt caccctcact gaattatcca ttcactgggt gcgacaggct 120 cctggaaaag ggcttgagtg gatgggaggt tttgatcctg aagatggtga aacaatctac 180 gcacagaagt tccagggcag agtcaccatg accgaggaca catctacaga cacagcctac 240 atggagctga ccagcctgag atcggaagac acggccgtgt attactgttc aacgattttt 300 ggagtggtta ccaactttga caactggggc cagggaaccc tggtcaccgt ctcctca 357 <210> 2 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Val Ser Gly Phe Thr Leu Thr Glu Leu 20 25 30 Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 65 70 75 80 Met Glu Leu Thr Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ser Thr Ile Phe Gly Val Val Thr Asn Phe Asp Asn Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 3 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3 ggattcaccc tcactgaatt atcc 24 <210> 4 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4 Gly Phe Thr Leu Thr Glu Leu Ser 1 5 <210> 5 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5 tttgatcctg aagatggtga aaca 24 <210> 6 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6 Phe Asp Pro Glu Asp Gly Glu Thr 1 5 <210> 7 <211> 36 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 7 tcaacgattt ttggagtggt taccaacttt gacaac 36 <210> 8 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 8 Ser Thr Ile Phe Gly Val Val Thr Asn Phe Asp Asn 1 5 10 <210> 9 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 9 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgcaggaga cagagtcacc 60 atcacttgcc gggcaagtca ggccattaga aatgatttag gctggtatca gcagaaacca 120 gggaaagccc ctaagcgcct gatctatgct gcattcaatt tgcaaagtgg ggtcccatca 180 agattcagcg gcagtggatc tgggacagaa ttcactctca caatcagtag cctgcagcct 240 gaagatcttg caagttatta ctgtcaacag tataatagat acccgtggac gttcggccaa 300 gggaccaagg tggaaatcaa acga 324 <210> 10 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 10 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Ala Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ala Ile Arg Asn Asp 20 25 30 Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 35 40 45 Tyr Ala Ala Phe Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Leu Ala Ser Tyr Tyr Cys Gln Gln Tyr Asn Arg Tyr Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 11 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 11 caggccatta gaaatgat 18 <210> 12 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 12 Gln Ala Ile Arg Asn Asp 1 5 <210> 13 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 13 gctgcattc 9 <210> 14 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 14 Ala Ala Phe 1 <210> 15 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 15 caacagtata atagataccc gtggacg 27 <210> 16 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 16 Gln Gln Tyr Asn Arg Tyr Pro Trp Thr 1 5 <210> 17 <211> 847 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 17 agcgtccgga cccaataaca gttttaccaa gggagcagct ttctatcctg gccacactga 60 ggtgcatagc gtaatgtcca tgttgttcta cactctgatc acagcttttc tgatcggcat 120 acaggcggaa ccacactcag agagcaatgt ccctgcagga cacaccatcc cccaagccca 180 ctggactaaa cttcagcatt cccttgacac tgcccttcgc agagcccgca gcgccccggc 240 agcggcgata gctgcacgcg tggcggggca gacccgcaac attactgtgg accccaggct 300 gtttaaaaag cggcgactcc gttcaccccg tgtgctgttt agcacccagc ctccccgtga 360 agctgcagac actcaggatc tggacttcga ggtcggtggt gctgccccct tcaacaggac 420 tcacaggagc aagcggtcat catcccatcc catcttccac aggggcgaat tctcggtgtg 480 tgacagtgtc agcgtgtggg ttggggataa gaccaccgcc acagacatca agggcaagga 540 ggtgatggtg ttgggagagg tgagcattaa caacagtgta ttcaaacagt acttttttga 600 gaccaagtgc cgggacccaa atcccgttga cagcgggtgc cggggcattg actcaaagca 660 ctggaactca tattgtacca cgactcacac ctttgtcaag gcgctgacca tggatggcaa 720 gcaggctgcc tggcggttta tccggataga tacggcctgt atgtgtgtgc tcagcaggaa 780 ggctgtgaga agagcctgac ctgccgacac gctccctccc cctgcccctt ctacactctc 840 ctgggcc 847 <210> 18 <211> 115 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 18 Ser Ser Ser His Pro Ile Phe His Arg Gly Glu Phe Ser Val Val Ser 1 5 10 15 Val Trp Val Gly Asp Lys Thr Thr Ala Thr Asp Ile Lys Gly Lys Glu 20 25 30 Val Met Val Leu Gly Glu Val Asn Ile Asn Asn Ser Val Phe Lys Gln 35 40 45 Tyr Phe Phe Glu Thr Lys Cys Arg Asp Pro Asn Pro Val Asp Ser Gly 50 55 60 Cys Arg Gly Ile Asp Ser Lys His Trp Asn Ser Tyr Cys Thr Thr Thr 65 70 75 80 His Thr Phe Ala Leu Thr Met Asp Gly Lys Gln Ala Ala Trp Arg Phe 85 90 95 Ile Arg Ile Asp Thr Ala Cys Val Cys Val Leu Ser Arg Lys Ala Val 100 105 110 Arg Arg Ala 115