LISTADO DE SECUENCIAS <110> Laboratorios del Dr. ESTEVE S. A. Universitat Autònoma de Barcelona <120> VECTORES VIRALES ADENOASOCIADOS QUE CODIFICAN PARA LA ENZIMA IDURONATO-2-SULFATASA <130> CO2212.6 <140> NC2017/0012562 <141> 2017-12-05 <150> EP15382297 <151> 2015-06-05 <160> 20 <170> PatentIn version 3.5 <210> 1 <211> 550 <212> PRT <213> Homo sapiens <400> 1 Met Pro Pro Pro Arg Thr Gly Arg Gly Leu Leu Trp Leu Gly Leu Val 1 5 10 15 Leu Ser Ser Val Cys Val Ala Leu Gly Ser Glu Thr Gln Ala Asn Ser 20 25 30 Thr Thr Asp Ala Leu Asn Val Leu Leu Ile Ile Val Asp Asp Leu Arg 35 40 45 Pro Ser Leu Gly Cys Tyr Gly Asp Lys Leu Val Arg Ser Pro Asn Ile 50 55 60 Asp Gln Leu Ala Ser His Ser Leu Leu Phe Gln Asn Ala Phe Ala Gln 65 70 75 80 Gln Ala Val Cys Ala Pro Ser Arg Val Ser Phe Leu Thr Gly Arg Arg 85 90 95 Pro Asp Thr Thr Arg Leu Tyr Asp Phe Asn Ser Tyr Trp Arg Val His 100 105 110 Ala Gly Asn Phe Ser Thr Ile Pro Gln Tyr Phe Lys Glu Asn Gly Tyr 115 120 125 Val Thr Met Ser Val Gly Lys Val Phe His Pro Gly Ile Ser Ser Asn 130 135 140 His Thr Asp Asp Ser Pro Tyr Ser Trp Ser Phe Pro Pro Tyr His Pro 145 150 155 160 Ser Ser Glu Lys Tyr Glu Asn Thr Lys Thr Cys Arg Gly Pro Asp Gly 165 170 175 Glu Leu His Ala Asn Leu Leu Cys Pro Val Asp Val Leu Asp Val Pro 180 185 190 Glu Gly Thr Leu Pro Asp Lys Gln Ser Thr Glu Gln Ala Ile Gln Leu 195 200 205 Leu Glu Lys Met Lys Thr Ser Ala Ser Pro Phe Phe Leu Ala Val Gly 210 215 220 Tyr His Lys Pro His Ile Pro Phe Arg Tyr Pro Lys Glu Phe Gln Lys 225 230 235 240 Leu Tyr Pro Leu Glu Asn Ile Thr Leu Ala Pro Asp Pro Glu Val Pro 245 250 255 Asp Gly Leu Pro Pro Val Ala Tyr Asn Pro Trp Met Asp Ile Arg Gln 260 265 270 Arg Glu Asp Val Gln Ala Leu Asn Ile Ser Val Pro Tyr Gly Pro Ile 275 280 285 Pro Val Asp Phe Gln Arg Lys Ile Arg Gln Ser Tyr Phe Ala Ser Val 290 295 300 Ser Tyr Leu Asp Thr Gln Val Gly Arg Leu Leu Ser Ala Leu Asp Asp 305 310 315 320 Leu Gln Leu Ala Asn Ser Thr Ile Ile Ala Phe Thr Ser Asp His Gly 325 330 335 Trp Ala Leu Gly Glu His Gly Glu Trp Ala Lys Tyr Ser Asn Phe Asp 340 345 350 Val Ala Thr His Val Pro Leu Ile Phe Tyr Val Pro Gly Arg Thr Ala 355 360 365 Ser Leu Pro Glu Ala Gly Glu Lys Leu Phe Pro Tyr Leu Asp Pro Phe 370 375 380 Asp Ser Ala Ser Gln Leu Met Glu Pro Gly Arg Gln Ser Met Asp Leu 385 390 395 400 Val Glu Leu Val Ser Leu Phe Pro Thr Leu Ala Gly Leu Ala Gly Leu 405 410 415 Gln Val Pro Pro Arg Cys Pro Val Pro Ser Phe His Val Glu Leu Cys 420 425 430 Arg Glu Gly Lys Asn Leu Leu Lys His Phe Arg Phe Arg Asp Leu Glu 435 440 445 Glu Asp Pro Tyr Leu Pro Gly Asn Pro Arg Glu Leu Ile Ala Tyr Ser 450 455 460 Gln Tyr Pro Arg Pro Ser Asp Ile Pro Gln Trp Asn Ser Asp Lys Pro 465 470 475 480 Ser Leu Lys Asp Ile Lys Ile Met Gly Tyr Ser Ile Arg Thr Ile Asp 485 490 495 Tyr Arg Tyr Thr Val Trp Val Gly Phe Asn Pro Asp Glu Phe Leu Ala 500 505 510 Asn Phe Ser Asp Ile His Ala Gly Glu Leu Tyr Phe Val Asp Ser Asp 515 520 525 Pro Leu Gln Asp His Asn Met Tyr Asn Asp Ser Gln Gly Gly Asp Leu 530 535 540 Phe Gln Leu Leu Met Pro 545 550 <210> 2 <211> 1653 <212> DNA <213> Homo sapiens <400> 2 atgccgccac cccggaccgg ccgaggcctt ctctggctgg gtctggttct gagctccgtc 60 tgcgtcgccc tcggatccga aacgcaggcc aactcgacca cagatgctct gaacgttctt 120 ctcatcatcg tggatgacct gcgcccctcc ctgggctgtt atggggataa gctggtgagg 180 tccccaaata ttgaccaact ggcatcccac agcctcctct tccagaatgc ctttgcgcag 240 caagcagtgt gcgccccgag ccgcgtttct ttcctcactg gcaggagacc tgacaccacc 300 cgcctgtacg acttcaactc ctactggagg gtgcacgctg gaaacttctc caccatcccc 360 cagtacttca aggagaatgg ctatgtgacc atgtcggtgg gaaaagtctt tcaccctggg 420 atatcttcta accataccga tgattctccg tatagctggt cttttccacc ttatcatcct 480 tcctctgaga agtatgaaaa cactaagaca tgtcgagggc cagatggaga actccatgcc 540 aacctgcttt gccctgtgga tgtgctggat gttcccgagg gcaccttgcc tgacaaacag 600 agcactgagc aagccataca gttgttggaa aagatgaaaa cgtcagccag tcctttcttc 660 ctggccgttg ggtatcataa gccacacatc cccttcagat accccaagga atttcagaag 720 ttgtatccct tggagaacat caccctggcc cccgatcccg aggtccctga tggcctaccc 780 cctgtggcct acaacccctg gatggacatc aggcaacggg aagacgtcca agccttaaac 840 atcagtgtgc cgtatggtcc aattcctgtg gactttcagc ggaaaatccg ccagagctac 900 tttgcctctg tgtcatattt ggatacacag gtcggccgcc tcttgagtgc tttggacgat 960 cttcagctgg ccaacagcac catcattgca tttacctcgg atcatgggtg ggctctaggt 1020 gaacatggag aatgggccaa atacagcaat tttgatgttg ctacccatgt tcccctgata 1080 ttctatgttc ctggaaggac ggcttcactt ccggaggcag gcgagaagct tttcccttac 1140 ctcgaccctt ttgattccgc ctcacagttg atggagccag gcaggcaatc catggacctt 1200 gtggaacttg tgtctctttt tcccacgctg gctggacttg caggactgca ggttccacct 1260 cgctgccccg ttccttcatt tcacgttgag ctgtgcagag aaggcaagaa ccttctgaag 1320 cattttcgat tccgtgactt ggaagaggat ccgtacctcc ctggtaatcc ccgtgaactg 1380 attgcctata gccagtatcc ccggccttca gacatccctc agtggaattc tgacaagccg 1440 agtttaaaag atataaagat catgggctat tccatacgca ccatagacta taggtatact 1500 gtgtgggttg gcttcaatcc tgatgaattt ctagctaact tttctgacat ccatgcaggg 1560 gaactgtatt ttgtggattc tgacccattg caggatcaca atatgtataa tgattcccaa 1620 ggtggagatc ttttccagtt gttgatgcct tga 1653 <210> 3 <211> 7900 <212> DNA <213> Secuencia Artificial <220> <223> pAAV-CAG-hIDS <400> 3 aaatacgcgt atgccgccac cccggaccgg ccgaggcctt ctctggctgg gtctggttct 60 gagctccgtc tgcgtcgccc tcggatccga aacgcaggcc aactcgacca cagatgctct 120 gaacgttctt ctcatcatcg tggatgacct gcgcccctcc ctgggctgtt atggggataa 180 gctggtgagg tccccaaata ttgaccaact ggcatcccac agcctcctct tccagaatgc 240 ctttgcgcag caagcagtgt gcgccccgag ccgcgtttct ttcctcactg gcaggagacc 300 tgacaccacc cgcctgtacg acttcaactc ctactggagg gtgcacgctg gaaacttctc 360 caccatcccc cagtacttca aggagaatgg ctatgtgacc atgtcggtgg gaaaagtctt 420 tcaccctggg atatcttcta accataccga tgattctccg tatagctggt cttttccacc 480 ttatcatcct tcctctgaga agtatgaaaa cactaagaca tgtcgagggc cagatggaga 540 actccatgcc aacctgcttt gccctgtgga tgtgctggat gttcccgagg gcaccttgcc 600 tgacaaacag agcactgagc aagccataca gttgttggaa aagatgaaaa cgtcagccag 660 tcctttcttc ctggccgttg ggtatcataa gccacacatc cccttcagat accccaagga 720 atttcagaag ttgtatccct tggagaacat caccctggcc cccgatcccg aggtccctga 780 tggcctaccc cctgtggcct acaacccctg gatggacatc aggcaacggg aagacgtcca 840 agccttaaac atcagtgtgc cgtatggtcc aattcctgtg gactttcagc ggaaaatccg 900 ccagagctac tttgcctctg tgtcatattt ggatacacag gtcggccgcc tcttgagtgc 960 tttggacgat cttcagctgg ccaacagcac catcattgca tttacctcgg atcatgggtg 1020 ggctctaggt gaacatggag aatgggccaa atacagcaat tttgatgttg ctacccatgt 1080 tcccctgata ttctatgttc ctggaaggac ggcttcactt ccggaggcag gcgagaagct 1140 tttcccttac ctcgaccctt ttgattccgc ctcacagttg atggagccag gcaggcaatc 1200 catggacctt gtggaacttg tgtctctttt tcccacgctg gctggacttg caggactgca 1260 ggttccacct cgctgccccg ttccttcatt tcacgttgag ctgtgcagag aaggcaagaa 1320 ccttctgaag cattttcgat tccgtgactt ggaagaggat ccgtacctcc ctggtaatcc 1380 ccgtgaactg attgcctata gccagtatcc ccggccttca gacatccctc agtggaattc 1440 tgacaagccg agtttaaaag atataaagat catgggctat tccatacgca ccatagacta 1500 taggtatact gtgtgggttg gcttcaatcc tgatgaattt ctagctaact tttctgacat 1560 ccatgcaggg gaactgtatt ttgtggattc tgacccattg caggatcaca atatgtataa 1620 tgattcccaa ggtggagatc ttttccagtt gttgatgcct tgagaattca tttaattcga 1680 gctcggtacc cgggaatcaa ttcactcctc aggtgcaggc tgcctatcag aaggtggtgg 1740 ctggtgtggc caatgccctg gctcacaaat accactgaga tctttttccc tctgccaaaa 1800 attatgggga catcatgaag ccccttgagc atctgacttc tggctaataa aggaaattta 1860 ttttcattgc aatagtgtgt tggaattttt tgtgtctctc actcggaagg acatatggga 1920 gggcaaatca tttaaaacat cagaatgagt atttggttta gagtttggca acatatgccc 1980 atatgctggc tgccatgaac aaaggttggc tataaagagg tcatcagtat atgaaacagc 2040 cccctgctgt ccattcctta ttccatagaa aagccttgac ttgaggttag atttttttta 2100 tattttgttt tgtgttattt ttttctttaa catccctaaa attttcctta catgttttac 2160 tagccagatt tttcctcctc tcctgactac tcccagtcat agctgtccct cttctcttat 2220 ggagatccct cgacctgcag cccaagctgt agataagtag catggcgggt taatcattaa 2280 ctacaaggaa cccctagtga tggagttggc cactccctct ctgcgcgctc gctcgctcac 2340 tgaggccgcc cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg cagctgcatt 2400 aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctct tccgcttcct 2460 cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca gctcactcaa 2520 aggcggtaat acggttatcc acagaatcag gggataacgc aggaaagaac atgtgagcaa 2580 aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc 2640 tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga 2700 caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc 2760 cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc gtggcgcttt 2820 ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc aagctgggct 2880 gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac tatcgtcttg 2940 agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt aacaggatta 3000 gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct aactacggct 3060 acactagaag aacagtattt ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa 3120 gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt 3180 gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta 3240 cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc atgagattat 3300 caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa tcaatctaaa 3360 gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag gcacctatct 3420 cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg tagataacta 3480 cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga gacccacgct 3540 caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag cgcagaagtg 3600 gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa gctagagtaa 3660 gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc atcgtggtgt 3720 cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca aggcgagtta 3780 catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca 3840 gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat aattctctta 3900 ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc aagtcattct 3960 gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg gataataccg 4020 cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg gggcgaaaac 4080 tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt gcacccaact 4140 gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa 4200 atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata ctcttccttt 4260 ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat 4320 gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa gtgccacctg 4380 acgtctaaga aaccattatt atcatgacat taacctataa aaataggcgt atcacgaggc 4440 cctttcgtct cgcgcgtttc ggtgatgacg gtgaaaacct ctgacacatg cagctcccgg 4500 agacggtcac agcttgtctg taagcggatg ccgggagcag acaagcccgt cagggcgcgt 4560 cagcgggtgt tggcgggtgt cggggctggc ttaactatgc ggcatcagag cagattgtac 4620 tgagagtgca ccatatgcgg tgtgaaatac cgcacagatg cgtaaggaga aaataccgca 4680 tcaggcgatt ccaacatcca ataaatcata caggcaaggc aaagaattag caaaattaag 4740 caataaagcc tcagagcata aagctaaatc ggttgtacca aaaacattat gaccctgtaa 4800 tacttttgcg ggagaagcct ttatttcaac gcaaggataa aaatttttag aaccctcata 4860 tattttaaat gcaatgcctg agtaatgtgt aggtaaagat tcaaacgggt gagaaaggcc 4920 ggagacagtc aaatcaccat caatatgata ttcaaccgtt ctagctgata aattcatgcc 4980 ggagagggta gctatttttg agaggtctct acaaaggcta tcaggtcatt gcctgagagt 5040 ctggagcaaa caagagaatc gatgaacggt aatcgtaaaa ctagcatgtc aatcatatgt 5100 accccggttg ataatcagaa aagccccaaa aacaggaaga ttgtataagc aaatatttaa 5160 attgtaagcg ttaatatttt gttaaaattc gcgttaaatt tttgttaaat cagctcattt 5220 tttaaccaat aggccgaaat cggcaaaatc ccttataaat caaaagaata gaccgagata 5280 gggttgagtg ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac 5340 gtcaaagggc gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa 5400 tcaagttttt tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc 5460 cgatttagag cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg 5520 aaaggagcgg gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca 5580 cccgccgcgc ttaatgcgcc gctacagggc gcgtactatg gttgctttga cgagcacgta 5640 taacgtgctt tcctcgttag aatcagagcg ggagctaaac aggaggccga ttaaagggat 5700 tttagacagg aacggtacgc cagaatcctg agaagtgttt ttataatcag tgaggccacc 5760 gagtaaaaga gtctgtccat cacgcaaatt aaccgttgtc gcaatacttc tttgattagt 5820 aataacatca cttgcctgag tagaagaact caaactatcg gccttgctgg taatatccag 5880 aacaatatta ccgccagcca ttgcaacgga atcgccattc gccattcagg ctgcgcaact 5940 gttgggaagg gcgatcggtg cgggcctctt cgctattacg ccagctgcgc gctcgctcgc 6000 tcactgaggc cgcccgggca aagcccgggc gtcgggcgac ctttggtcgc ccggcctcag 6060 tgagcgagcg agcgcgcaga gagggagtgg ccaactccat cactaggggt tccttgtagt 6120 taatgattaa cccgccatgc tacttatcta ctcgacattg attattgact agttattaat 6180 agtaatcaat tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac 6240 ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa 6300 tgacgtatgt tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt 6360 atttacggta aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc 6420 ctattgacgt caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat 6480 gggactttcc tacttggcag tacatctacg tattagtcat cgctattacc atggtcgagg 6540 tgagccccac gttctgcttc actctcccca tctccccccc ctccccaccc ccaattttgt 6600 atttatttat tttttaatta ttttgtgcag cgatgggggc gggggggggg ggggggcgcg 6660 cgccaggcgg ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg 6720 cagccaatca gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc 6780 ggccctataa aaagcgaagc gcgcggcggg cgggagtcgc tgcgttgcct tcgccccgtg 6840 ccccgctccg ccgccgcctc gcgccgcccg ccccggctct gactgaccgc gttactccca 6900 caggtgagcg ggcgggacgg cccttctcct ccgggctgta attagcgctt ggtttaatga 6960 cggcttgttt cttttctgtg gctgcgtgaa agccttgagg ggctccggga gggccctttg 7020 tgcgggggga gcggctcggg gggtgcgtgc gtgtgtgtgt gcgtggggag cgccgcgtgc 7080 ggctccgcgc tgcccggcgg ctgtgagcgc tgcgggcgcg gcgcggggct ttgtgcgctc 7140 cgcagtgtgc gcgaggggag cgcggccggg ggcggtgccc cgcggtgcgg ggggggctgc 7200 gaggggaaca aaggctgcgt gcggggtgtg tgcgtggggg ggtgagcagg gggtgtgggc 7260 gcgtcggtcg ggctgcaacc ccccctgcac ccccctcccc gagttgctga gcacggcccg 7320 gcttcgggtg cggggctccg tacggggcgt ggcgcggggc tcgccgtgcc gggcgggggg 7380 tggcggcagg tgggggtgcc gggcggggcg gggccgcctc gggccgggga gggctcgggg 7440 gaggggcgcg gcggcccccg gagcgccggc ggctgtcgag gcgcggcgag ccgcagccat 7500 tgccttttat ggtaatcgtg cgagagggcg cagggacttc ctttgtccca aatctgtgcg 7560 gagccgaaat ctgggaggcg ccgccgcacc ccctctagcg ggcgcggggc gaagcggtgc 7620 ggcgccggca ggaaggaaat gggcggggag ggccttcgtg cgtcgccgcg ccgccgtccc 7680 cttctccctc tccagcctcg gggctgtccg cggggggacg gctgccttcg ggggggacgg 7740 ggcagggcgg ggttcggctt ctggcgtgtg accggcggct ctagagcctc tgctaaccat 7800 gttcatgcct tcttcttttt cctacagctc ctgggcaacg tgctggttat tgtgctgtct 7860 catcattttg gcaaagaatt gattaattcg agcgaacgcg 7900 <210> 4 <211> 4319 <212> DNA <213> Secuencia Artificial <220> <223> AAV9-CAG-hIDS <400> 4 attacgccag ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg 60 ggcgaccttt ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa 120 ctccatcact aggggttcct tgtagttaat gattaacccg ccatgctact tatctactcg 180 acattgatta ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc 240 atatatggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa 300 cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac 360 tttccattga cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca 420 agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg 480 gcattatgcc cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt 540 agtcatcgct attaccatgg tcgaggtgag ccccacgttc tgcttcactc tccccatctc 600 ccccccctcc ccacccccaa ttttgtattt atttattttt taattatttt gtgcagcgat 660 gggggcgggg gggggggggg ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg 720 cggggcgagg cggagaggtg cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc 780 ttttatggcg aggcggcggc ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcggg 840 agtcgctgcg ttgccttcgc cccgtgcccc gctccgccgc cgcctcgcgc cgcccgcccc 900 ggctctgact gaccgcgtta ctcccacagg tgagcgggcg ggacggccct tctcctccgg 960 gctgtaatta gcgcttggtt taatgacggc ttgtttcttt tctgtggctg cgtgaaagcc 1020 ttgaggggct ccgggagggc cctttgtgcg gggggagcgg ctcggggggt gcgtgcgtgt 1080 gtgtgtgcgt ggggagcgcc gcgtgcggct ccgcgctgcc cggcggctgt gagcgctgcg 1140 ggcgcggcgc ggggctttgt gcgctccgca gtgtgcgcga ggggagcgcg gccgggggcg 1200 gtgccccgcg gtgcgggggg ggctgcgagg ggaacaaagg ctgcgtgcgg ggtgtgtgcg 1260 tgggggggtg agcagggggt gtgggcgcgt cggtcgggct gcaacccccc ctgcaccccc 1320 ctccccgagt tgctgagcac ggcccggctt cgggtgcggg gctccgtacg gggcgtggcg 1380 cggggctcgc cgtgccgggc ggggggtggc ggcaggtggg ggtgccgggc ggggcggggc 1440 cgcctcgggc cggggagggc tcgggggagg ggcgcggcgg cccccggagc gccggcggct 1500 gtcgaggcgc ggcgagccgc agccattgcc ttttatggta atcgtgcgag agggcgcagg 1560 gacttccttt gtcccaaatc tgtgcggagc cgaaatctgg gaggcgccgc cgcaccccct 1620 ctagcgggcg cggggcgaag cggtgcggcg ccggcaggaa ggaaatgggc ggggagggcc 1680 ttcgtgcgtc gccgcgccgc cgtccccttc tccctctcca gcctcggggc tgtccgcggg 1740 gggacggctg ccttcggggg ggacggggca gggcggggtt cggcttctgg cgtgtgaccg 1800 gcggctctag agcctctgct aaccatgttc atgccttctt ctttttccta cagctcctgg 1860 gcaacgtgct ggttattgtg ctgtctcatc attttggcaa agaattgatt aattcgagcg 1920 aacgcgaaat acgcgtatgc cgccaccccg gaccggccga ggccttctct ggctgggtct 1980 ggttctgagc tccgtctgcg tcgccctcgg atccgaaacg caggccaact cgaccacaga 2040 tgctctgaac gttcttctca tcatcgtgga tgacctgcgc ccctccctgg gctgttatgg 2100 ggataagctg gtgaggtccc caaatattga ccaactggca tcccacagcc tcctcttcca 2160 gaatgccttt gcgcagcaag cagtgtgcgc cccgagccgc gtttctttcc tcactggcag 2220 gagacctgac accacccgcc tgtacgactt caactcctac tggagggtgc acgctggaaa 2280 cttctccacc atcccccagt acttcaagga gaatggctat gtgaccatgt cggtgggaaa 2340 agtctttcac cctgggatat cttctaacca taccgatgat tctccgtata gctggtcttt 2400 tccaccttat catccttcct ctgagaagta tgaaaacact aagacatgtc gagggccaga 2460 tggagaactc catgccaacc tgctttgccc tgtggatgtg ctggatgttc ccgagggcac 2520 cttgcctgac aaacagagca ctgagcaagc catacagttg ttggaaaaga tgaaaacgtc 2580 agccagtcct ttcttcctgg ccgttgggta tcataagcca cacatcccct tcagataccc 2640 caaggaattt cagaagttgt atcccttgga gaacatcacc ctggcccccg atcccgaggt 2700 ccctgatggc ctaccccctg tggcctacaa cccctggatg gacatcaggc aacgggaaga 2760 cgtccaagcc ttaaacatca gtgtgccgta tggtccaatt cctgtggact ttcagcggaa 2820 aatccgccag agctactttg cctctgtgtc atatttggat acacaggtcg gccgcctctt 2880 gagtgctttg gacgatcttc agctggccaa cagcaccatc attgcattta cctcggatca 2940 tgggtgggct ctaggtgaac atggagaatg ggccaaatac agcaattttg atgttgctac 3000 ccatgttccc ctgatattct atgttcctgg aaggacggct tcacttccgg aggcaggcga 3060 gaagcttttc ccttacctcg acccttttga ttccgcctca cagttgatgg agccaggcag 3120 gcaatccatg gaccttgtgg aacttgtgtc tctttttccc acgctggctg gacttgcagg 3180 actgcaggtt ccacctcgct gccccgttcc ttcatttcac gttgagctgt gcagagaagg 3240 caagaacctt ctgaagcatt ttcgattccg tgacttggaa gaggatccgt acctccctgg 3300 taatccccgt gaactgattg cctatagcca gtatccccgg ccttcagaca tccctcagtg 3360 gaattctgac aagccgagtt taaaagatat aaagatcatg ggctattcca tacgcaccat 3420 agactatagg tatactgtgt gggttggctt caatcctgat gaatttctag ctaacttttc 3480 tgacatccat gcaggggaac tgtattttgt ggattctgac ccattgcagg atcacaatat 3540 gtataatgat tcccaaggtg gagatctttt ccagttgttg atgccttgag aattcattta 3600 attcgagctc ggtacccggg aatcaattca ctcctcaggt gcaggctgcc tatcagaagg 3660 tggtggctgg tgtggccaat gccctggctc acaaatacca ctgagatctt tttccctctg 3720 ccaaaaatta tggggacatc atgaagcccc ttgagcatct gacttctggc taataaagga 3780 aatttatttt cattgcaata gtgtgttgga attttttgtg tctctcactc ggaaggacat 3840 atgggagggc aaatcattta aaacatcaga atgagtattt ggtttagagt ttggcaacat 3900 atgcccatat gctggctgcc atgaacaaag gttggctata aagaggtcat cagtatatga 3960 aacagccccc tgctgtccat tccttattcc atagaaaagc cttgacttga ggttagattt 4020 tttttatatt ttgttttgtg ttattttttt ctttaacatc cctaaaattt tccttacatg 4080 ttttactagc cagatttttc ctcctctcct gactactccc agtcatagct gtccctcttc 4140 tcttatggag atccctcgac ctgcagccca agctgtagat aagtagcatg gcgggttaat 4200 cattaactac aaggaacccc tagtgatgga gttggccact ccctctctgc gcgctcgctc 4260 gctcactgag gccgcccggg ctttgcccgg gcggcctcag tgagcgagcg agcgcgcag 4319 <210> 5 <211> 1653 <212> DNA <213> Secuencia Artificial <220> <223> ohIDS-version1 <400> 5 atgcccccac ctagaaccgg aagaggattg ctctggctcg gacttgtgct gtccagcgtg 60 tgtgtggccc tgggctcgga aacccaggcc aacagcacca ccgacgccct gaatgtgctg 120 ctgattatcg tggacgatct ccggccttcg ctgggctgct acggggataa gctggtccgc 180 tccccgaata tcgaccaact ggcttcacat agcctgcttt tccaaaacgc attcgcccaa 240 caagccgtgt gcgccccgag ccgcgtgtct ttcctcaccg gccggcgccc tgatactacc 300 cggctctacg acttcaacag ctactggaga gtgcacgcag gaaacttctc caccattcct 360 cagtacttta aggagaacgg ttacgtcacc atgagcgtgg ggaaggtgtt ccaccctgga 420 atttcctcca accacaccga cgactcgcca tactcctggt cctttccccc ttaccaccca 480 tcatccgaga agtacgagaa caccaagacg tgcaggggcc cagacgggga actgcacgcg 540 aacctcctct gcccggtcga tgtgctggat gtgcccgaag gcaccctccc tgacaaacag 600 agcaccgaac aggccatcca gctcctcgag aagatgaaaa cttcagcctc cccgttcttt 660 ctggccgtgg gataccacaa gccgcatatc cccttccggt acccaaagga gttccagaag 720 ctgtacccgc tggagaacat taccctggct cctgatcccg aagtgccgga cggcctgccg 780 cccgtggcat acaacccttg gatggacatc cgccagaggg aggatgtgca agccctgaac 840 atctccgtgc catacggtcc gatcccggtc gacttccagc ggaagattag gcagtcatat 900 ttcgcgtccg tgtcctactt ggacactcag gtcggacgcc tcctctccgc tctcgacgat 960 ctgcagctgg ccaactcgac cattatcgcg ttcacctcgg accatggttg ggctctgggc 1020 gaacacggag aatgggccaa gtacagcaat ttcgatgtcg cgactcacgt gcccctgatc 1080 ttctacgtgc ccggacgcac agccagcttg cctgaagcgg gggaaaagct gttcccttac 1140 ctggatccct tcgactccgc ctctcaactt atggagccag gcagacagtc gatggacctg 1200 gtggaactcg tgtcactgtt ccctaccctc gccggtctgg ccggacttca ggtcccgcct 1260 cggtgcccgg tgccgtcctt ccacgtggag ctgtgtcgcg agggaaagaa cctcctgaaa 1320 cacttccggt tccgcgacct ggaggaagat ccctacttgc cgggcaaccc gagagaactt 1380 atcgcatact cccagtaccc tcgcccctcc gacatcccgc agtggaactc cgacaagccg 1440 agcctgaagg acattaagat catggggtac tccatccgga ctattgacta tcggtacact 1500 gtgtgggtcg ggttcaaccc agatgagttt ctggccaact tctccgatat ccatgccgga 1560 gagctgtact tcgtggactc ggacccgctg caggaccaca acatgtacaa cgactcacag 1620 ggcggcgacc tgttccagtt gctgatgccc tga 1653 <210> 6 <211> 7888 <212> DNA <213> Secuencia Artificial <220> <223> pAAV-CAG-ohIDS-version1 <400> 6 cgcgtgccac catgccccca cctagaaccg gaagaggatt gctctggctc ggacttgtgc 60 tgtccagcgt gtgtgtggcc ctgggctcgg aaacccaggc caacagcacc accgacgccc 120 tgaatgtgct gctgattatc gtggacgatc tccggccttc gctgggctgc tacggggata 180 agctggtccg ctccccgaat atcgaccaac tggcttcaca tagcctgctt ttccaaaacg 240 cattcgccca acaagccgtg tgcgccccga gccgcgtgtc tttcctcacc ggccggcgcc 300 ctgatactac ccggctctac gacttcaaca gctactggag agtgcacgca ggaaacttct 360 ccaccattcc tcagtacttt aaggagaacg gttacgtcac catgagcgtg gggaaggtgt 420 tccaccctgg aatttcctcc aaccacaccg acgactcgcc atactcctgg tcctttcccc 480 cttaccaccc atcatccgag aagtacgaga acaccaagac gtgcaggggc ccagacgggg 540 aactgcacgc gaacctcctc tgcccggtcg atgtgctgga tgtgcccgaa ggcaccctcc 600 ctgacaaaca gagcaccgaa caggccatcc agctcctcga gaagatgaaa acttcagcct 660 ccccgttctt tctggccgtg ggataccaca agccgcatat ccccttccgg tacccaaagg 720 agttccagaa gctgtacccg ctggagaaca ttaccctggc tcctgatccc gaagtgccgg 780 acggcctgcc gcccgtggca tacaaccctt ggatggacat ccgccagagg gaggatgtgc 840 aagccctgaa catctccgtg ccatacggtc cgatcccggt cgacttccag cggaagatta 900 ggcagtcata tttcgcgtcc gtgtcctact tggacactca ggtcggacgc ctcctctccg 960 ctctcgacga tctgcagctg gccaactcga ccattatcgc gttcacctcg gaccatggtt 1020 gggctctggg cgaacacgga gaatgggcca agtacagcaa tttcgatgtc gcgactcacg 1080 tgcccctgat cttctacgtg cccggacgca cagccagctt gcctgaagcg ggggaaaagc 1140 tgttccctta cctggatccc ttcgactccg cctctcaact tatggagcca ggcagacagt 1200 cgatggacct ggtggaactc gtgtcactgt tccctaccct cgccggtctg gccggacttc 1260 aggtcccgcc tcggtgcccg gtgccgtcct tccacgtgga gctgtgtcgc gagggaaaga 1320 acctcctgaa acacttccgg ttccgcgacc tggaggaaga tccctacttg ccgggcaacc 1380 cgagagaact tatcgcatac tcccagtacc ctcgcccctc cgacatcccg cagtggaact 1440 ccgacaagcc gagcctgaag gacattaaga tcatggggta ctccatccgg actattgact 1500 atcggtacac tgtgtgggtc gggttcaacc cagatgagtt tctggccaac ttctccgata 1560 tccatgccgg agagctgtac ttcgtggact cggacccgct gcaggaccac aacatgtaca 1620 acgactcaca gggcggcgac ctgttccagt tgctgatgcc ctgagaattc gagctcggta 1680 cccgggaatc aattcactcc tcaggtgcag gctgcctatc agaaggtggt ggctggtgtg 1740 gccaatgccc tggctcacaa ataccactga gatctttttc cctctgccaa aaattatggg 1800 gacatcatga agccccttga gcatctgact tctggctaat aaaggaaatt tattttcatt 1860 gcaatagtgt gttggaattt tttgtgtctc tcactcggaa ggacatatgg gagggcaaat 1920 catttaaaac atcagaatga gtatttggtt tagagtttgg caacatatgc ccatatgctg 1980 gctgccatga acaaaggttg gctataaaga ggtcatcagt atatgaaaca gccccctgct 2040 gtccattcct tattccatag aaaagccttg acttgaggtt agattttttt tatattttgt 2100 tttgtgttat ttttttcttt aacatcccta aaattttcct tacatgtttt actagccaga 2160 tttttcctcc tctcctgact actcccagtc atagctgtcc ctcttctctt atggagatcc 2220 ctcgacctgc agcccaagct gtagataagt agcatggcgg gttaatcatt aactacaagg 2280 aacccctagt gatggagttg gccactccct ctctgcgcgc tcgctcgctc actgaggccg 2340 cccgggcttt gcccgggcgg cctcagtgag cgagcgagcg cgcagctgca ttaatgaatc 2400 ggccaacgcg cggggagagg cggtttgcgt attgggcgct cttccgcttc ctcgctcact 2460 gactcgctgc gctcggtcgt tcggctgcgg cgagcggtat cagctcactc aaaggcggta 2520 atacggttat ccacagaatc aggggataac gcaggaaaga acatgtgagc aaaaggccag 2580 caaaaggcca ggaaccgtaa aaaggccgcg ttgctggcgt ttttccatag gctccgcccc 2640 cctgacgagc atcacaaaaa tcgacgctca agtcagaggt ggcgaaaccc gacaggacta 2700 taaagatacc aggcgtttcc ccctggaagc tccctcgtgc gctctcctgt tccgaccctg 2760 ccgcttaccg gatacctgtc cgcctttctc ccttcgggaa gcgtggcgct ttctcatagc 2820 tcacgctgta ggtatctcag ttcggtgtag gtcgttcgct ccaagctggg ctgtgtgcac 2880 gaaccccccg ttcagcccga ccgctgcgcc ttatccggta actatcgtct tgagtccaac 2940 ccggtaagac acgacttatc gccactggca gcagccactg gtaacaggat tagcagagcg 3000 aggtatgtag gcggtgctac agagttcttg aagtggtggc ctaactacgg ctacactaga 3060 agaacagtat ttggtatctg cgctctgctg aagccagtta ccttcggaaa aagagttggt 3120 agctcttgat ccggcaaaca aaccaccgct ggtagcggtg gtttttttgt ttgcaagcag 3180 cagattacgc gcagaaaaaa aggatctcaa gaagatcctt tgatcttttc tacggggtct 3240 gacgctcagt ggaacgaaaa ctcacgttaa gggattttgg tcatgagatt atcaaaaagg 3300 atcttcacct agatcctttt aaattaaaaa tgaagtttta aatcaatcta aagtatatat 3360 gagtaaactt ggtctgacag ttaccaatgc ttaatcagtg aggcacctat ctcagcgatc 3420 tgtctatttc gttcatccat agttgcctga ctccccgtcg tgtagataac tacgatacgg 3480 gagggcttac catctggccc cagtgctgca atgataccgc gagacccacg ctcaccggct 3540 ccagatttat cagcaataaa ccagccagcc ggaagggccg agcgcagaag tggtcctgca 3600 actttatccg cctccatcca gtctattaat tgttgccggg aagctagagt aagtagttcg 3660 ccagttaata gtttgcgcaa cgttgttgcc attgctacag gcatcgtggt gtcacgctcg 3720 tcgtttggta tggcttcatt cagctccggt tcccaacgat caaggcgagt tacatgatcc 3780 cccatgttgt gcaaaaaagc ggttagctcc ttcggtcctc cgatcgttgt cagaagtaag 3840 ttggccgcag tgttatcact catggttatg gcagcactgc ataattctct tactgtcatg 3900 ccatccgtaa gatgcttttc tgtgactggt gagtactcaa ccaagtcatt ctgagaatag 3960 tgtatgcggc gaccgagttg ctcttgcccg gcgtcaatac gggataatac cgcgccacat 4020 agcagaactt taaaagtgct catcattgga aaacgttctt cggggcgaaa actctcaagg 4080 atcttaccgc tgttgagatc cagttcgatg taacccactc gtgcacccaa ctgatcttca 4140 gcatctttta ctttcaccag cgtttctggg tgagcaaaaa caggaaggca aaatgccgca 4200 aaaaagggaa taagggcgac acggaaatgt tgaatactca tactcttcct ttttcaatat 4260 tattgaagca tttatcaggg ttattgtctc atgagcggat acatatttga atgtatttag 4320 aaaaataaac aaataggggt tccgcgcaca tttccccgaa aagtgccacc tgacgtctaa 4380 gaaaccatta ttatcatgac attaacctat aaaaataggc gtatcacgag gccctttcgt 4440 ctcgcgcgtt tcggtgatga cggtgaaaac ctctgacaca tgcagctccc ggagacggtc 4500 acagcttgtc tgtaagcgga tgccgggagc agacaagccc gtcagggcgc gtcagcgggt 4560 gttggcgggt gtcggggctg gcttaactat gcggcatcag agcagattgt actgagagtg 4620 caccatatgc ggtgtgaaat accgcacaga tgcgtaagga gaaaataccg catcaggcga 4680 ttccaacatc caataaatca tacaggcaag gcaaagaatt agcaaaatta agcaataaag 4740 cctcagagca taaagctaaa tcggttgtac caaaaacatt atgaccctgt aatacttttg 4800 cgggagaagc ctttatttca acgcaaggat aaaaattttt agaaccctca tatattttaa 4860 atgcaatgcc tgagtaatgt gtaggtaaag attcaaacgg gtgagaaagg ccggagacag 4920 tcaaatcacc atcaatatga tattcaaccg ttctagctga taaattcatg ccggagaggg 4980 tagctatttt tgagaggtct ctacaaaggc tatcaggtca ttgcctgaga gtctggagca 5040 aacaagagaa tcgatgaacg gtaatcgtaa aactagcatg tcaatcatat gtaccccggt 5100 tgataatcag aaaagcccca aaaacaggaa gattgtataa gcaaatattt aaattgtaag 5160 cgttaatatt ttgttaaaat tcgcgttaaa tttttgttaa atcagctcat tttttaacca 5220 ataggccgaa atcggcaaaa tcccttataa atcaaaagaa tagaccgaga tagggttgag 5280 tgttgttcca gtttggaaca agagtccact attaaagaac gtggactcca acgtcaaagg 5340 gcgaaaaacc gtctatcagg gcgatggccc actacgtgaa ccatcaccct aatcaagttt 5400 tttggggtcg aggtgccgta aagcactaaa tcggaaccct aaagggagcc cccgatttag 5460 agcttgacgg ggaaagccgg cgaacgtggc gagaaaggaa gggaagaaag cgaaaggagc 5520 gggcgctagg gcgctggcaa gtgtagcggt cacgctgcgc gtaaccacca cacccgccgc 5580 gcttaatgcg ccgctacagg gcgcgtacta tggttgcttt gacgagcacg tataacgtgc 5640 tttcctcgtt agaatcagag cgggagctaa acaggaggcc gattaaaggg attttagaca 5700 ggaacggtac gccagaatcc tgagaagtgt ttttataatc agtgaggcca ccgagtaaaa 5760 gagtctgtcc atcacgcaaa ttaaccgttg tcgcaatact tctttgatta gtaataacat 5820 cacttgcctg agtagaagaa ctcaaactat cggccttgct ggtaatatcc agaacaatat 5880 taccgccagc cattgcaacg gaatcgccat tcgccattca ggctgcgcaa ctgttgggaa 5940 gggcgatcgg tgcgggcctc ttcgctatta cgccagctgc gcgctcgctc gctcactgag 6000 gccgcccggg caaagcccgg gcgtcgggcg acctttggtc gcccggcctc agtgagcgag 6060 cgagcgcgca gagagggagt ggccaactcc atcactaggg gttccttgta gttaatgatt 6120 aacccgccat gctacttatc tactcgacat tgattattga ctagttatta atagtaatca 6180 attacggggt cattagttca tagcccatat atggagttcc gcgttacata acttacggta 6240 aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat aatgacgtat 6300 gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga gtatttacgg 6360 taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc ccctattgac 6420 gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt atgggacttt 6480 cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtcga ggtgagcccc 6540 acgttctgct tcactctccc catctccccc ccctccccac ccccaatttt gtatttattt 6600 attttttaat tattttgtgc agcgatgggg gcgggggggg ggggggggcg cgcgccaggc 6660 ggggcggggc ggggcgaggg gcggggcggg gcgaggcgga gaggtgcggc ggcagccaat 6720 cagagcggcg cgctccgaaa gtttcctttt atggcgaggc ggcggcggcg gcggccctat 6780 aaaaagcgaa gcgcgcggcg ggcgggagtc gctgcgttgc cttcgccccg tgccccgctc 6840 cgccgccgcc tcgcgccgcc cgccccggct ctgactgacc gcgttactcc cacaggtgag 6900 cgggcgggac ggcccttctc ctccgggctg taattagcgc ttggtttaat gacggcttgt 6960 ttcttttctg tggctgcgtg aaagccttga ggggctccgg gagggccctt tgtgcggggg 7020 gagcggctcg gggggtgcgt gcgtgtgtgt gtgcgtgggg agcgccgcgt gcggctccgc 7080 gctgcccggc ggctgtgagc gctgcgggcg cggcgcgggg ctttgtgcgc tccgcagtgt 7140 gcgcgagggg agcgcggccg ggggcggtgc cccgcggtgc ggggggggct gcgaggggaa 7200 caaaggctgc gtgcggggtg tgtgcgtggg ggggtgagca gggggtgtgg gcgcgtcggt 7260 cgggctgcaa ccccccctgc acccccctcc ccgagttgct gagcacggcc cggcttcggg 7320 tgcggggctc cgtacggggc gtggcgcggg gctcgccgtg ccgggcgggg ggtggcggca 7380 ggtgggggtg ccgggcgggg cggggccgcc tcgggccggg gagggctcgg gggaggggcg 7440 cggcggcccc cggagcgccg gcggctgtcg aggcgcggcg agccgcagcc attgcctttt 7500 atggtaatcg tgcgagaggg cgcagggact tcctttgtcc caaatctgtg cggagccgaa 7560 atctgggagg cgccgccgca ccccctctag cgggcgcggg gcgaagcggt gcggcgccgg 7620 caggaaggaa atgggcgggg agggccttcg tgcgtcgccg cgccgccgtc cccttctccc 7680 tctccagcct cggggctgtc cgcgggggga cggctgcctt cgggggggac ggggcagggc 7740 ggggttcggc ttctggcgtg tgaccggcgg ctctagagcc tctgctaacc atgttcatgc 7800 cttcttcttt ttcctacagc tcctgggcaa cgtgctggtt attgtgctgt ctcatcattt 7860 tggcaaagaa ttgattaatt cgagcgaa 7888 <210> 7 <211> 4307 <212> DNA <213> Secuencia Artificial <220> <223> AAV9-CAG-ohIDS-version1 <400> 7 attacgccag ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg 60 ggcgaccttt ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa 120 ctccatcact aggggttcct tgtagttaat gattaacccg ccatgctact tatctactcg 180 acattgatta ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc 240 atatatggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa 300 cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac 360 tttccattga cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca 420 agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg 480 gcattatgcc cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt 540 agtcatcgct attaccatgg tcgaggtgag ccccacgttc tgcttcactc tccccatctc 600 ccccccctcc ccacccccaa ttttgtattt atttattttt taattatttt gtgcagcgat 660 gggggcgggg gggggggggg ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg 720 cggggcgagg cggagaggtg cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc 780 ttttatggcg aggcggcggc ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcggg 840 agtcgctgcg ttgccttcgc cccgtgcccc gctccgccgc cgcctcgcgc cgcccgcccc 900 ggctctgact gaccgcgtta ctcccacagg tgagcgggcg ggacggccct tctcctccgg 960 gctgtaatta gcgcttggtt taatgacggc ttgtttcttt tctgtggctg cgtgaaagcc 1020 ttgaggggct ccgggagggc cctttgtgcg gggggagcgg ctcggggggt gcgtgcgtgt 1080 gtgtgtgcgt ggggagcgcc gcgtgcggct ccgcgctgcc cggcggctgt gagcgctgcg 1140 ggcgcggcgc ggggctttgt gcgctccgca gtgtgcgcga ggggagcgcg gccgggggcg 1200 gtgccccgcg gtgcgggggg ggctgcgagg ggaacaaagg ctgcgtgcgg ggtgtgtgcg 1260 tgggggggtg agcagggggt gtgggcgcgt cggtcgggct gcaacccccc ctgcaccccc 1320 ctccccgagt tgctgagcac ggcccggctt cgggtgcggg gctccgtacg gggcgtggcg 1380 cggggctcgc cgtgccgggc ggggggtggc ggcaggtggg ggtgccgggc ggggcggggc 1440 cgcctcgggc cggggagggc tcgggggagg ggcgcggcgg cccccggagc gccggcggct 1500 gtcgaggcgc ggcgagccgc agccattgcc ttttatggta atcgtgcgag agggcgcagg 1560 gacttccttt gtcccaaatc tgtgcggagc cgaaatctgg gaggcgccgc cgcaccccct 1620 ctagcgggcg cggggcgaag cggtgcggcg ccggcaggaa ggaaatgggc ggggagggcc 1680 ttcgtgcgtc gccgcgccgc cgtccccttc tccctctcca gcctcggggc tgtccgcggg 1740 gggacggctg ccttcggggg ggacggggca gggcggggtt cggcttctgg cgtgtgaccg 1800 gcggctctag agcctctgct aaccatgttc atgccttctt ctttttccta cagctcctgg 1860 gcaacgtgct ggttattgtg ctgtctcatc attttggcaa agaattgatt aattcgagcg 1920 aacgcgtgcc accatgcccc cacctagaac cggaagagga ttgctctggc tcggacttgt 1980 gctgtccagc gtgtgtgtgg ccctgggctc ggaaacccag gccaacagca ccaccgacgc 2040 cctgaatgtg ctgctgatta tcgtggacga tctccggcct tcgctgggct gctacgggga 2100 taagctggtc cgctccccga atatcgacca actggcttca catagcctgc ttttccaaaa 2160 cgcattcgcc caacaagccg tgtgcgcccc gagccgcgtg tctttcctca ccggccggcg 2220 ccctgatact acccggctct acgacttcaa cagctactgg agagtgcacg caggaaactt 2280 ctccaccatt cctcagtact ttaaggagaa cggttacgtc accatgagcg tggggaaggt 2340 gttccaccct ggaatttcct ccaaccacac cgacgactcg ccatactcct ggtcctttcc 2400 cccttaccac ccatcatccg agaagtacga gaacaccaag acgtgcaggg gcccagacgg 2460 ggaactgcac gcgaacctcc tctgcccggt cgatgtgctg gatgtgcccg aaggcaccct 2520 ccctgacaaa cagagcaccg aacaggccat ccagctcctc gagaagatga aaacttcagc 2580 ctccccgttc tttctggccg tgggatacca caagccgcat atccccttcc ggtacccaaa 2640 ggagttccag aagctgtacc cgctggagaa cattaccctg gctcctgatc ccgaagtgcc 2700 ggacggcctg ccgcccgtgg catacaaccc ttggatggac atccgccaga gggaggatgt 2760 gcaagccctg aacatctccg tgccatacgg tccgatcccg gtcgacttcc agcggaagat 2820 taggcagtca tatttcgcgt ccgtgtccta cttggacact caggtcggac gcctcctctc 2880 cgctctcgac gatctgcagc tggccaactc gaccattatc gcgttcacct cggaccatgg 2940 ttgggctctg ggcgaacacg gagaatgggc caagtacagc aatttcgatg tcgcgactca 3000 cgtgcccctg atcttctacg tgcccggacg cacagccagc ttgcctgaag cgggggaaaa 3060 gctgttccct tacctggatc ccttcgactc cgcctctcaa cttatggagc caggcagaca 3120 gtcgatggac ctggtggaac tcgtgtcact gttccctacc ctcgccggtc tggccggact 3180 tcaggtcccg cctcggtgcc cggtgccgtc cttccacgtg gagctgtgtc gcgagggaaa 3240 gaacctcctg aaacacttcc ggttccgcga cctggaggaa gatccctact tgccgggcaa 3300 cccgagagaa cttatcgcat actcccagta ccctcgcccc tccgacatcc cgcagtggaa 3360 ctccgacaag ccgagcctga aggacattaa gatcatgggg tactccatcc ggactattga 3420 ctatcggtac actgtgtggg tcgggttcaa cccagatgag tttctggcca acttctccga 3480 tatccatgcc ggagagctgt acttcgtgga ctcggacccg ctgcaggacc acaacatgta 3540 caacgactca cagggcggcg acctgttcca gttgctgatg ccctgagaat tcgagctcgg 3600 tacccgggaa tcaattcact cctcaggtgc aggctgccta tcagaaggtg gtggctggtg 3660 tggccaatgc cctggctcac aaataccact gagatctttt tccctctgcc aaaaattatg 3720 gggacatcat gaagcccctt gagcatctga cttctggcta ataaaggaaa tttattttca 3780 ttgcaatagt gtgttggaat tttttgtgtc tctcactcgg aaggacatat gggagggcaa 3840 atcatttaaa acatcagaat gagtatttgg tttagagttt ggcaacatat gcccatatgc 3900 tggctgccat gaacaaaggt tggctataaa gaggtcatca gtatatgaaa cagccccctg 3960 ctgtccattc cttattccat agaaaagcct tgacttgagg ttagattttt tttatatttt 4020 gttttgtgtt atttttttct ttaacatccc taaaattttc cttacatgtt ttactagcca 4080 gatttttcct cctctcctga ctactcccag tcatagctgt ccctcttctc ttatggagat 4140 ccctcgacct gcagcccaag ctgtagataa gtagcatggc gggttaatca ttaactacaa 4200 ggaaccccta gtgatggagt tggccactcc ctctctgcgc gctcgctcgc tcactgaggc 4260 cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag cgcgcag 4307 <210> 8 <211> 1653 <212> DNA <213> Secuencia Artificial <220> <223> ohIDS-version2 <400> 8 atgcctcctc ctagaactgg aagggggctg ctgtggctgg ggctggtcct gtcatcagtg 60 tgtgtcgctc tgggctccga gactcaggca aactccacca cagacgccct gaatgtgctg 120 ctgatcattg tcgacgatct gcgaccttcc ctggggtgct acggcgacaa gctggtgagg 180 tctccaaaca tcgatcagct ggcttcacac agcctgctgt tccagaatgc ctttgctcag 240 caggcagtgt gtgcaccatc acgggtcagc ttcctgaccg gaaggagacc tgacactacc 300 aggctgtacg attttaactc atattggaga gtgcatgccg ggaatttcag caccatccca 360 cagtacttta aggagaacgg ctatgtgaca atgtccgtgg gaaaagtctt ccaccccggc 420 attagctcca atcatacaga cgattctcca tactcctggt cttttccccc ttatcacccc 480 tctagtgaga agtacgaaaa cacaaaaact tgcaggggac cagacgggga gctgcatgca 540 aatctgctgt gtcccgtgga cgtcctggat gtgcccgaag gcacactgcc tgataagcag 600 agcactgagc aggccattca gctgctggaa aagatgaaaa caagtgcttc acccttcttt 660 ctggcagtgg gatatcacaa accacatatc cccttcagat atcccaagga gtttcagaaa 720 ctgtaccctc tggaaaacat tactctggct cccgaccctg aggtgcctga tggactgcca 780 cccgtcgcat ataacccatg gatggacatc cggcagcgcg aggatgtgca ggccctgaat 840 atcagtgtcc cttacgggcc aattcccgtg gacttccaga gaaagattcg gcagtcttac 900 tttgccagcg tctcctatct ggatactcaa gtgggacgac tgctgagcgc tctggacgat 960 ctgcagctgg ccaacagcac catcattgct ttcacatccg accacggatg ggctctggga 1020 gagcatggag aatgggcaaa gtatagcaat ttcgatgtgg ccactcacgt cccactgatc 1080 ttttacgtgc ccggccgaac cgcatccctg ccagaggctg gagaaaaact gttcccttac 1140 ctggacccat ttgattctgc tagtcagctg atggagcctg gccgacagtc tatggacctg 1200 gtggaactgg tcagtctgtt ccctacactg gctggactgg caggactgca ggtgcctcca 1260 agatgccctg tgccatcttt tcacgtcgag ctgtgtcggg aaggcaagaa cctgctgaaa 1320 catttcaggt tcagggacct ggaggaagat ccttatctgc caggaaatcc cagggagctg 1380 atcgcctaca gtcagtatcc ccgcccttca gacattcctc agtggaactc cgacaagcca 1440 tctctgaagg atatcaaaat tatgggatac agcatccgca ctattgatta ccgatatacc 1500 gtgtgggtcg ggttcaaccc cgacgagttc ctggcaaatt ttagtgatat ccacgccggc 1560 gaactgtatt ttgtggactc agatcctctg caggaccata acatgtacaa tgacagccag 1620 ggcggagatc tgttccagct gctgatgcca tga 1653 <210> 9 <211> 7888 <212> DNA <213> Secuencia Artificial <220> <223> pAAV-CAG-ohIDS-version2 <400> 9 cgcgtgccac catgcctcct cctagaactg gaagggggct gctgtggctg gggctggtcc 60 tgtcatcagt gtgtgtcgct ctgggctccg agactcaggc aaactccacc acagacgccc 120 tgaatgtgct gctgatcatt gtcgacgatc tgcgaccttc cctggggtgc tacggcgaca 180 agctggtgag gtctccaaac atcgatcagc tggcttcaca cagcctgctg ttccagaatg 240 cctttgctca gcaggcagtg tgtgcaccat cacgggtcag cttcctgacc ggaaggagac 300 ctgacactac caggctgtac gattttaact catattggag agtgcatgcc gggaatttca 360 gcaccatccc acagtacttt aaggagaacg gctatgtgac aatgtccgtg ggaaaagtct 420 tccaccccgg cattagctcc aatcatacag acgattctcc atactcctgg tcttttcccc 480 cttatcaccc ctctagtgag aagtacgaaa acacaaaaac ttgcagggga ccagacgggg 540 agctgcatgc aaatctgctg tgtcccgtgg acgtcctgga tgtgcccgaa ggcacactgc 600 ctgataagca gagcactgag caggccattc agctgctgga aaagatgaaa acaagtgctt 660 cacccttctt tctggcagtg ggatatcaca aaccacatat ccccttcaga tatcccaagg 720 agtttcagaa actgtaccct ctggaaaaca ttactctggc tcccgaccct gaggtgcctg 780 atggactgcc acccgtcgca tataacccat ggatggacat ccggcagcgc gaggatgtgc 840 aggccctgaa tatcagtgtc ccttacgggc caattcccgt ggacttccag agaaagattc 900 ggcagtctta ctttgccagc gtctcctatc tggatactca agtgggacga ctgctgagcg 960 ctctggacga tctgcagctg gccaacagca ccatcattgc tttcacatcc gaccacggat 1020 gggctctggg agagcatgga gaatgggcaa agtatagcaa tttcgatgtg gccactcacg 1080 tcccactgat cttttacgtg cccggccgaa ccgcatccct gccagaggct ggagaaaaac 1140 tgttccctta cctggaccca tttgattctg ctagtcagct gatggagcct ggccgacagt 1200 ctatggacct ggtggaactg gtcagtctgt tccctacact ggctggactg gcaggactgc 1260 aggtgcctcc aagatgccct gtgccatctt ttcacgtcga gctgtgtcgg gaaggcaaga 1320 acctgctgaa acatttcagg ttcagggacc tggaggaaga tccttatctg ccaggaaatc 1380 ccagggagct gatcgcctac agtcagtatc cccgcccttc agacattcct cagtggaact 1440 ccgacaagcc atctctgaag gatatcaaaa ttatgggata cagcatccgc actattgatt 1500 accgatatac cgtgtgggtc gggttcaacc ccgacgagtt cctggcaaat tttagtgata 1560 tccacgccgg cgaactgtat tttgtggact cagatcctct gcaggaccat aacatgtaca 1620 atgacagcca gggcggagat ctgttccagc tgctgatgcc atgagaattc gagctcggta 1680 cccgggaatc aattcactcc tcaggtgcag gctgcctatc agaaggtggt ggctggtgtg 1740 gccaatgccc tggctcacaa ataccactga gatctttttc cctctgccaa aaattatggg 1800 gacatcatga agccccttga gcatctgact tctggctaat aaaggaaatt tattttcatt 1860 gcaatagtgt gttggaattt tttgtgtctc tcactcggaa ggacatatgg gagggcaaat 1920 catttaaaac atcagaatga gtatttggtt tagagtttgg caacatatgc ccatatgctg 1980 gctgccatga acaaaggttg gctataaaga ggtcatcagt atatgaaaca gccccctgct 2040 gtccattcct tattccatag aaaagccttg acttgaggtt agattttttt tatattttgt 2100 tttgtgttat ttttttcttt aacatcccta aaattttcct tacatgtttt actagccaga 2160 tttttcctcc tctcctgact actcccagtc atagctgtcc ctcttctctt atggagatcc 2220 ctcgacctgc agcccaagct gtagataagt agcatggcgg gttaatcatt aactacaagg 2280 aacccctagt gatggagttg gccactccct ctctgcgcgc tcgctcgctc actgaggccg 2340 cccgggcttt gcccgggcgg cctcagtgag cgagcgagcg cgcagctgca ttaatgaatc 2400 ggccaacgcg cggggagagg cggtttgcgt attgggcgct cttccgcttc ctcgctcact 2460 gactcgctgc gctcggtcgt tcggctgcgg cgagcggtat cagctcactc aaaggcggta 2520 atacggttat ccacagaatc aggggataac gcaggaaaga acatgtgagc aaaaggccag 2580 caaaaggcca ggaaccgtaa aaaggccgcg ttgctggcgt ttttccatag gctccgcccc 2640 cctgacgagc atcacaaaaa tcgacgctca agtcagaggt ggcgaaaccc gacaggacta 2700 taaagatacc aggcgtttcc ccctggaagc tccctcgtgc gctctcctgt tccgaccctg 2760 ccgcttaccg gatacctgtc cgcctttctc ccttcgggaa gcgtggcgct ttctcatagc 2820 tcacgctgta ggtatctcag ttcggtgtag gtcgttcgct ccaagctggg ctgtgtgcac 2880 gaaccccccg ttcagcccga ccgctgcgcc ttatccggta actatcgtct tgagtccaac 2940 ccggtaagac acgacttatc gccactggca gcagccactg gtaacaggat tagcagagcg 3000 aggtatgtag gcggtgctac agagttcttg aagtggtggc ctaactacgg ctacactaga 3060 agaacagtat ttggtatctg cgctctgctg aagccagtta ccttcggaaa aagagttggt 3120 agctcttgat ccggcaaaca aaccaccgct ggtagcggtg gtttttttgt ttgcaagcag 3180 cagattacgc gcagaaaaaa aggatctcaa gaagatcctt tgatcttttc tacggggtct 3240 gacgctcagt ggaacgaaaa ctcacgttaa gggattttgg tcatgagatt atcaaaaagg 3300 atcttcacct agatcctttt aaattaaaaa tgaagtttta aatcaatcta aagtatatat 3360 gagtaaactt ggtctgacag ttaccaatgc ttaatcagtg aggcacctat ctcagcgatc 3420 tgtctatttc gttcatccat agttgcctga ctccccgtcg tgtagataac tacgatacgg 3480 gagggcttac catctggccc cagtgctgca atgataccgc gagacccacg ctcaccggct 3540 ccagatttat cagcaataaa ccagccagcc ggaagggccg agcgcagaag tggtcctgca 3600 actttatccg cctccatcca gtctattaat tgttgccggg aagctagagt aagtagttcg 3660 ccagttaata gtttgcgcaa cgttgttgcc attgctacag gcatcgtggt gtcacgctcg 3720 tcgtttggta tggcttcatt cagctccggt tcccaacgat caaggcgagt tacatgatcc 3780 cccatgttgt gcaaaaaagc ggttagctcc ttcggtcctc cgatcgttgt cagaagtaag 3840 ttggccgcag tgttatcact catggttatg gcagcactgc ataattctct tactgtcatg 3900 ccatccgtaa gatgcttttc tgtgactggt gagtactcaa ccaagtcatt ctgagaatag 3960 tgtatgcggc gaccgagttg ctcttgcccg gcgtcaatac gggataatac cgcgccacat 4020 agcagaactt taaaagtgct catcattgga aaacgttctt cggggcgaaa actctcaagg 4080 atcttaccgc tgttgagatc cagttcgatg taacccactc gtgcacccaa ctgatcttca 4140 gcatctttta ctttcaccag cgtttctggg tgagcaaaaa caggaaggca aaatgccgca 4200 aaaaagggaa taagggcgac acggaaatgt tgaatactca tactcttcct ttttcaatat 4260 tattgaagca tttatcaggg ttattgtctc atgagcggat acatatttga atgtatttag 4320 aaaaataaac aaataggggt tccgcgcaca tttccccgaa aagtgccacc tgacgtctaa 4380 gaaaccatta ttatcatgac attaacctat aaaaataggc gtatcacgag gccctttcgt 4440 ctcgcgcgtt tcggtgatga cggtgaaaac ctctgacaca tgcagctccc ggagacggtc 4500 acagcttgtc tgtaagcgga tgccgggagc agacaagccc gtcagggcgc gtcagcgggt 4560 gttggcgggt gtcggggctg gcttaactat gcggcatcag agcagattgt actgagagtg 4620 caccatatgc ggtgtgaaat accgcacaga tgcgtaagga gaaaataccg catcaggcga 4680 ttccaacatc caataaatca tacaggcaag gcaaagaatt agcaaaatta agcaataaag 4740 cctcagagca taaagctaaa tcggttgtac caaaaacatt atgaccctgt aatacttttg 4800 cgggagaagc ctttatttca acgcaaggat aaaaattttt agaaccctca tatattttaa 4860 atgcaatgcc tgagtaatgt gtaggtaaag attcaaacgg gtgagaaagg ccggagacag 4920 tcaaatcacc atcaatatga tattcaaccg ttctagctga taaattcatg ccggagaggg 4980 tagctatttt tgagaggtct ctacaaaggc tatcaggtca ttgcctgaga gtctggagca 5040 aacaagagaa tcgatgaacg gtaatcgtaa aactagcatg tcaatcatat gtaccccggt 5100 tgataatcag aaaagcccca aaaacaggaa gattgtataa gcaaatattt aaattgtaag 5160 cgttaatatt ttgttaaaat tcgcgttaaa tttttgttaa atcagctcat tttttaacca 5220 ataggccgaa atcggcaaaa tcccttataa atcaaaagaa tagaccgaga tagggttgag 5280 tgttgttcca gtttggaaca agagtccact attaaagaac gtggactcca acgtcaaagg 5340 gcgaaaaacc gtctatcagg gcgatggccc actacgtgaa ccatcaccct aatcaagttt 5400 tttggggtcg aggtgccgta aagcactaaa tcggaaccct aaagggagcc cccgatttag 5460 agcttgacgg ggaaagccgg cgaacgtggc gagaaaggaa gggaagaaag cgaaaggagc 5520 gggcgctagg gcgctggcaa gtgtagcggt cacgctgcgc gtaaccacca cacccgccgc 5580 gcttaatgcg ccgctacagg gcgcgtacta tggttgcttt gacgagcacg tataacgtgc 5640 tttcctcgtt agaatcagag cgggagctaa acaggaggcc gattaaaggg attttagaca 5700 ggaacggtac gccagaatcc tgagaagtgt ttttataatc agtgaggcca ccgagtaaaa 5760 gagtctgtcc atcacgcaaa ttaaccgttg tcgcaatact tctttgatta gtaataacat 5820 cacttgcctg agtagaagaa ctcaaactat cggccttgct ggtaatatcc agaacaatat 5880 taccgccagc cattgcaacg gaatcgccat tcgccattca ggctgcgcaa ctgttgggaa 5940 gggcgatcgg tgcgggcctc ttcgctatta cgccagctgc gcgctcgctc gctcactgag 6000 gccgcccggg caaagcccgg gcgtcgggcg acctttggtc gcccggcctc agtgagcgag 6060 cgagcgcgca gagagggagt ggccaactcc atcactaggg gttccttgta gttaatgatt 6120 aacccgccat gctacttatc tactcgacat tgattattga ctagttatta atagtaatca 6180 attacggggt cattagttca tagcccatat atggagttcc gcgttacata acttacggta 6240 aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat aatgacgtat 6300 gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga gtatttacgg 6360 taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc ccctattgac 6420 gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt atgggacttt 6480 cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtcga ggtgagcccc 6540 acgttctgct tcactctccc catctccccc ccctccccac ccccaatttt gtatttattt 6600 attttttaat tattttgtgc agcgatgggg gcgggggggg ggggggggcg cgcgccaggc 6660 ggggcggggc ggggcgaggg gcggggcggg gcgaggcgga gaggtgcggc ggcagccaat 6720 cagagcggcg cgctccgaaa gtttcctttt atggcgaggc ggcggcggcg gcggccctat 6780 aaaaagcgaa gcgcgcggcg ggcgggagtc gctgcgttgc cttcgccccg tgccccgctc 6840 cgccgccgcc tcgcgccgcc cgccccggct ctgactgacc gcgttactcc cacaggtgag 6900 cgggcgggac ggcccttctc ctccgggctg taattagcgc ttggtttaat gacggcttgt 6960 ttcttttctg tggctgcgtg aaagccttga ggggctccgg gagggccctt tgtgcggggg 7020 gagcggctcg gggggtgcgt gcgtgtgtgt gtgcgtgggg agcgccgcgt gcggctccgc 7080 gctgcccggc ggctgtgagc gctgcgggcg cggcgcgggg ctttgtgcgc tccgcagtgt 7140 gcgcgagggg agcgcggccg ggggcggtgc cccgcggtgc ggggggggct gcgaggggaa 7200 caaaggctgc gtgcggggtg tgtgcgtggg ggggtgagca gggggtgtgg gcgcgtcggt 7260 cgggctgcaa ccccccctgc acccccctcc ccgagttgct gagcacggcc cggcttcggg 7320 tgcggggctc cgtacggggc gtggcgcggg gctcgccgtg ccgggcgggg ggtggcggca 7380 ggtgggggtg ccgggcgggg cggggccgcc tcgggccggg gagggctcgg gggaggggcg 7440 cggcggcccc cggagcgccg gcggctgtcg aggcgcggcg agccgcagcc attgcctttt 7500 atggtaatcg tgcgagaggg cgcagggact tcctttgtcc caaatctgtg cggagccgaa 7560 atctgggagg cgccgccgca ccccctctag cgggcgcggg gcgaagcggt gcggcgccgg 7620 caggaaggaa atgggcgggg agggccttcg tgcgtcgccg cgccgccgtc cccttctccc 7680 tctccagcct cggggctgtc cgcgggggga cggctgcctt cgggggggac ggggcagggc 7740 ggggttcggc ttctggcgtg tgaccggcgg ctctagagcc tctgctaacc atgttcatgc 7800 cttcttcttt ttcctacagc tcctgggcaa cgtgctggtt attgtgctgt ctcatcattt 7860 tggcaaagaa ttgattaatt cgagcgaa 7888 <210> 10 <211> 4307 <212> DNA <213> Secuencia Artificial <220> <223> AAV9-CAG-ohIDS-version2 <400> 10 attacgccag ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg 60 ggcgaccttt ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa 120 ctccatcact aggggttcct tgtagttaat gattaacccg ccatgctact tatctactcg 180 acattgatta ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc 240 atatatggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa 300 cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac 360 tttccattga cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca 420 agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg 480 gcattatgcc cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt 540 agtcatcgct attaccatgg tcgaggtgag ccccacgttc tgcttcactc tccccatctc 600 ccccccctcc ccacccccaa ttttgtattt atttattttt taattatttt gtgcagcgat 660 gggggcgggg gggggggggg ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg 720 cggggcgagg cggagaggtg cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc 780 ttttatggcg aggcggcggc ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcggg 840 agtcgctgcg ttgccttcgc cccgtgcccc gctccgccgc cgcctcgcgc cgcccgcccc 900 ggctctgact gaccgcgtta ctcccacagg tgagcgggcg ggacggccct tctcctccgg 960 gctgtaatta gcgcttggtt taatgacggc ttgtttcttt tctgtggctg cgtgaaagcc 1020 ttgaggggct ccgggagggc cctttgtgcg gggggagcgg ctcggggggt gcgtgcgtgt 1080 gtgtgtgcgt ggggagcgcc gcgtgcggct ccgcgctgcc cggcggctgt gagcgctgcg 1140 ggcgcggcgc ggggctttgt gcgctccgca gtgtgcgcga ggggagcgcg gccgggggcg 1200 gtgccccgcg gtgcgggggg ggctgcgagg ggaacaaagg ctgcgtgcgg ggtgtgtgcg 1260 tgggggggtg agcagggggt gtgggcgcgt cggtcgggct gcaacccccc ctgcaccccc 1320 ctccccgagt tgctgagcac ggcccggctt cgggtgcggg gctccgtacg gggcgtggcg 1380 cggggctcgc cgtgccgggc ggggggtggc ggcaggtggg ggtgccgggc ggggcggggc 1440 cgcctcgggc cggggagggc tcgggggagg ggcgcggcgg cccccggagc gccggcggct 1500 gtcgaggcgc ggcgagccgc agccattgcc ttttatggta atcgtgcgag agggcgcagg 1560 gacttccttt gtcccaaatc tgtgcggagc cgaaatctgg gaggcgccgc cgcaccccct 1620 ctagcgggcg cggggcgaag cggtgcggcg ccggcaggaa ggaaatgggc ggggagggcc 1680 ttcgtgcgtc gccgcgccgc cgtccccttc tccctctcca gcctcggggc tgtccgcggg 1740 gggacggctg ccttcggggg ggacggggca gggcggggtt cggcttctgg cgtgtgaccg 1800 gcggctctag agcctctgct aaccatgttc atgccttctt ctttttccta cagctcctgg 1860 gcaacgtgct ggttattgtg ctgtctcatc attttggcaa agaattgatt aattcgagcg 1920 aacgcgtgcc accatgcctc ctcctagaac tggaaggggg ctgctgtggc tggggctggt 1980 cctgtcatca gtgtgtgtcg ctctgggctc cgagactcag gcaaactcca ccacagacgc 2040 cctgaatgtg ctgctgatca ttgtcgacga tctgcgacct tccctggggt gctacggcga 2100 caagctggtg aggtctccaa acatcgatca gctggcttca cacagcctgc tgttccagaa 2160 tgcctttgct cagcaggcag tgtgtgcacc atcacgggtc agcttcctga ccggaaggag 2220 acctgacact accaggctgt acgattttaa ctcatattgg agagtgcatg ccgggaattt 2280 cagcaccatc ccacagtact ttaaggagaa cggctatgtg acaatgtccg tgggaaaagt 2340 cttccacccc ggcattagct ccaatcatac agacgattct ccatactcct ggtcttttcc 2400 cccttatcac ccctctagtg agaagtacga aaacacaaaa acttgcaggg gaccagacgg 2460 ggagctgcat gcaaatctgc tgtgtcccgt ggacgtcctg gatgtgcccg aaggcacact 2520 gcctgataag cagagcactg agcaggccat tcagctgctg gaaaagatga aaacaagtgc 2580 ttcacccttc tttctggcag tgggatatca caaaccacat atccccttca gatatcccaa 2640 ggagtttcag aaactgtacc ctctggaaaa cattactctg gctcccgacc ctgaggtgcc 2700 tgatggactg ccacccgtcg catataaccc atggatggac atccggcagc gcgaggatgt 2760 gcaggccctg aatatcagtg tcccttacgg gccaattccc gtggacttcc agagaaagat 2820 tcggcagtct tactttgcca gcgtctccta tctggatact caagtgggac gactgctgag 2880 cgctctggac gatctgcagc tggccaacag caccatcatt gctttcacat ccgaccacgg 2940 atgggctctg ggagagcatg gagaatgggc aaagtatagc aatttcgatg tggccactca 3000 cgtcccactg atcttttacg tgcccggccg aaccgcatcc ctgccagagg ctggagaaaa 3060 actgttccct tacctggacc catttgattc tgctagtcag ctgatggagc ctggccgaca 3120 gtctatggac ctggtggaac tggtcagtct gttccctaca ctggctggac tggcaggact 3180 gcaggtgcct ccaagatgcc ctgtgccatc ttttcacgtc gagctgtgtc gggaaggcaa 3240 gaacctgctg aaacatttca ggttcaggga cctggaggaa gatccttatc tgccaggaaa 3300 tcccagggag ctgatcgcct acagtcagta tccccgccct tcagacattc ctcagtggaa 3360 ctccgacaag ccatctctga aggatatcaa aattatggga tacagcatcc gcactattga 3420 ttaccgatat accgtgtggg tcgggttcaa ccccgacgag ttcctggcaa attttagtga 3480 tatccacgcc ggcgaactgt attttgtgga ctcagatcct ctgcaggacc ataacatgta 3540 caatgacagc cagggcggag atctgttcca gctgctgatg ccatgagaat tcgagctcgg 3600 tacccgggaa tcaattcact cctcaggtgc aggctgccta tcagaaggtg gtggctggtg 3660 tggccaatgc cctggctcac aaataccact gagatctttt tccctctgcc aaaaattatg 3720 gggacatcat gaagcccctt gagcatctga cttctggcta ataaaggaaa tttattttca 3780 ttgcaatagt gtgttggaat tttttgtgtc tctcactcgg aaggacatat gggagggcaa 3840 atcatttaaa acatcagaat gagtatttgg tttagagttt ggcaacatat gcccatatgc 3900 tggctgccat gaacaaaggt tggctataaa gaggtcatca gtatatgaaa cagccccctg 3960 ctgtccattc cttattccat agaaaagcct tgacttgagg ttagattttt tttatatttt 4020 gttttgtgtt atttttttct ttaacatccc taaaattttc cttacatgtt ttactagcca 4080 gatttttcct cctctcctga ctactcccag tcatagctgt ccctcttctc ttatggagat 4140 ccctcgacct gcagcccaag ctgtagataa gtagcatggc gggttaatca ttaactacaa 4200 ggaaccccta gtgatggagt tggccactcc ctctctgcgc gctcgctcgc tcactgaggc 4260 cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag cgcgcag 4307 <210> 11 <211> 1665 <212> DNA <213> Secuencia Artificial <220> <223> omIDS <400> 11 atgagcccac ctcccccacc cccaatctgg cggcagctga gcttcagcct gctgctgggc 60 agcttctgta tcgccctgga aagcgccaag cttgcccagg gcaacagcgc caccgacgcc 120 ctgaacatcc tgctgatcat cgtggacgac ctgaggccca gcctgggatg ctacggcgac 180 aagctggtcc gcagccccaa catcgaccag ctggcttctc acagcgtgct gttccagaac 240 gcattcgcac agcaggccgt gtgcgccccc agcagagtgt ctttcctgac cggcagaagg 300 cccgacacca ccagactgta cgacttcaac agctactggc gggtgcacag cggcaacttc 360 agcaccatcc cccagtactt caaagaaaac ggctacgtga ccatgagcgt gggcaaggtg 420 ttccaccccg gcatcagcag caaccacagc gacgactacc cctacagctg gtccttccca 480 ccctaccacc ccagcagcga gaagtacgag aacaccaaga cctgcaaggg ccaggacggc 540 aagctgcacg ccaacctgct gtgccctgtg gacgtggcag acgtgccaga gggaaccctg 600 cctgacaagc agagcaccga ggaagccatc agactgctgg aaaagatgaa gaccagcgcc 660 agccccttct tcctggccgt gggctaccac aagccccaca tccctttcag ataccccaaa 720 gagttccaga agctgtaccc cctggaaaac atcaccctgg cccccgaccc ccacgtgcca 780 gattctctgc cccccgtggc ctacaacccc tggatggata tccgcgagcg cgaggacgtg 840 caggctctga acatcagcgt gccctacggc cctatccccg aggacttcca gagaaagatc 900 agacagagct acttcgccag cgtgtcctac ctggacaccc aagtgggaca cgtgctgagc 960 gccctggacg atctgagact ggcccacaac accatcattg ccttcaccag cgaccacggc 1020 tgggctctgg gagagcacgg cgagtgggcc aagtacagca acttcgacgt ggccaccaga 1080 gtgcccctga tgctgtacgt gcccggcaga accgcccctc tgcctgccgc tggacagaag 1140 ctgttccctt accgggaccc cttcgacccc gccagcgatt ggatggacgc cggcagacac 1200 accgaggacc tggtggaact ggtgtccctg ttccccaccc tggccggact ggctggactg 1260 cctgtgcccc ccagatgccc catccctagc ttccacgtcg aactgtgcag agagggccag 1320 aacctgcaga aacatctgca gctgcacgac ctggaagagg aacccgacct gttcggcaac 1380 cccagagagc tgatcgccta cagccagtac cccagacccg ccgacttccc ccagtggaac 1440 agcgacaagc ccagcctgaa cgacatcaaa gtgatgggct acagcatcag gaccgtggac 1500 tacagataca ccgtgtgggt cggattcgac cccagcgagt tcctggccaa cttcagcgac 1560 atccacgccg gcgagctgta cttcgtggac agcgaccccc tgcaggacca caacgtgtac 1620 aacgacagcc agcacggcgg cctgctgcac agcctgaggc cttga 1665 <210> 12 <211> 7914 <212> DNA <213> Secuencia Artificial <220> <223> pAAV-CAG-omIDS <400> 12 cgcgtgctag cgccaccatg agcccacctc ccccaccccc aatctggcgg cagctgagct 60 tcagcctgct gctgggcagc ttctgtatcg ccctggaaag cgccaagctt gcccagggca 120 acagcgccac cgacgccctg aacatcctgc tgatcatcgt ggacgacctg aggcccagcc 180 tgggatgcta cggcgacaag ctggtccgca gccccaacat cgaccagctg gcttctcaca 240 gcgtgctgtt ccagaacgca ttcgcacagc aggccgtgtg cgcccccagc agagtgtctt 300 tcctgaccgg cagaaggccc gacaccacca gactgtacga cttcaacagc tactggcggg 360 tgcacagcgg caacttcagc accatccccc agtacttcaa agaaaacggc tacgtgacca 420 tgagcgtggg caaggtgttc caccccggca tcagcagcaa ccacagcgac gactacccct 480 acagctggtc cttcccaccc taccacccca gcagcgagaa gtacgagaac accaagacct 540 gcaagggcca ggacggcaag ctgcacgcca acctgctgtg ccctgtggac gtggcagacg 600 tgccagaggg aaccctgcct gacaagcaga gcaccgagga agccatcaga ctgctggaaa 660 agatgaagac cagcgccagc cccttcttcc tggccgtggg ctaccacaag ccccacatcc 720 ctttcagata ccccaaagag ttccagaagc tgtaccccct ggaaaacatc accctggccc 780 ccgaccccca cgtgccagat tctctgcccc ccgtggccta caacccctgg atggatatcc 840 gcgagcgcga ggacgtgcag gctctgaaca tcagcgtgcc ctacggccct atccccgagg 900 acttccagag aaagatcaga cagagctact tcgccagcgt gtcctacctg gacacccaag 960 tgggacacgt gctgagcgcc ctggacgatc tgagactggc ccacaacacc atcattgcct 1020 tcaccagcga ccacggctgg gctctgggag agcacggcga gtgggccaag tacagcaact 1080 tcgacgtggc caccagagtg cccctgatgc tgtacgtgcc cggcagaacc gcccctctgc 1140 ctgccgctgg acagaagctg ttcccttacc gggacccctt cgaccccgcc agcgattgga 1200 tggacgccgg cagacacacc gaggacctgg tggaactggt gtccctgttc cccaccctgg 1260 ccggactggc tggactgcct gtgcccccca gatgccccat ccctagcttc cacgtcgaac 1320 tgtgcagaga gggccagaac ctgcagaaac atctgcagct gcacgacctg gaagaggaac 1380 ccgacctgtt cggcaacccc agagagctga tcgcctacag ccagtacccc agacccgccg 1440 acttccccca gtggaacagc gacaagccca gcctgaacga catcaaagtg atgggctaca 1500 gcatcaggac cgtggactac agatacaccg tgtgggtcgg attcgacccc agcgagttcc 1560 tggccaactt cagcgacatc cacgccggcg agctgtactt cgtggacagc gaccccctgc 1620 aggaccacaa cgtgtacaac gacagccagc acggcggcct gctgcacagc ctgaggcctt 1680 gagcggccgc gaattcgagc tcggtacccg ggaatcaatt cactcctcag gtgcaggctg 1740 cctatcagaa ggtggtggct ggtgtggcca atgccctggc tcacaaatac cactgagatc 1800 tttttccctc tgccaaaaat tatggggaca tcatgaagcc ccttgagcat ctgacttctg 1860 gctaataaag gaaatttatt ttcattgcaa tagtgtgttg gaattttttg tgtctctcac 1920 tcggaaggac atatgggagg gcaaatcatt taaaacatca gaatgagtat ttggtttaga 1980 gtttggcaac atatgcccat atgctggctg ccatgaacaa aggttggcta taaagaggtc 2040 atcagtatat gaaacagccc cctgctgtcc attccttatt ccatagaaaa gccttgactt 2100 gaggttagat tttttttata ttttgttttg tgttattttt ttctttaaca tccctaaaat 2160 tttccttaca tgttttacta gccagatttt tcctcctctc ctgactactc ccagtcatag 2220 ctgtccctct tctcttatgg agatccctcg acctgcagcc caagctgtag ataagtagca 2280 tggcgggtta atcattaact acaaggaacc cctagtgatg gagttggcca ctccctctct 2340 gcgcgctcgc tcgctcactg aggccgcccg ggctttgccc gggcggcctc agtgagcgag 2400 cgagcgcgca gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg 2460 ggcgctcttc cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg ctgcggcgag 2520 cggtatcagc tcactcaaag gcggtaatac ggttatccac agaatcaggg gataacgcag 2580 gaaagaacat gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc 2640 tggcgttttt ccataggctc cgcccccctg acgagcatca caaaaatcga cgctcaagtc 2700 agaggtggcg aaacccgaca ggactataaa gataccaggc gtttccccct ggaagctccc 2760 tcgtgcgctc tcctgttccg accctgccgc ttaccggata cctgtccgcc tttctccctt 2820 cgggaagcgt ggcgctttct catagctcac gctgtaggta tctcagttcg gtgtaggtcg 2880 ttcgctccaa gctgggctgt gtgcacgaac cccccgttca gcccgaccgc tgcgccttat 2940 ccggtaacta tcgtcttgag tccaacccgg taagacacga cttatcgcca ctggcagcag 3000 ccactggtaa caggattagc agagcgaggt atgtaggcgg tgctacagag ttcttgaagt 3060 ggtggcctaa ctacggctac actagaagaa cagtatttgg tatctgcgct ctgctgaagc 3120 cagttacctt cggaaaaaga gttggtagct cttgatccgg caaacaaacc accgctggta 3180 gcggtggttt ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag 3240 atcctttgat cttttctacg gggtctgacg ctcagtggaa cgaaaactca cgttaaggga 3300 ttttggtcat gagattatca aaaaggatct tcacctagat ccttttaaat taaaaatgaa 3360 gttttaaatc aatctaaagt atatatgagt aaacttggtc tgacagttac caatgcttaa 3420 tcagtgaggc acctatctca gcgatctgtc tatttcgttc atccatagtt gcctgactcc 3480 ccgtcgtgta gataactacg atacgggagg gcttaccatc tggccccagt gctgcaatga 3540 taccgcgaga cccacgctca ccggctccag atttatcagc aataaaccag ccagccggaa 3600 gggccgagcg cagaagtggt cctgcaactt tatccgcctc catccagtct attaattgtt 3660 gccgggaagc tagagtaagt agttcgccag ttaatagttt gcgcaacgtt gttgccattg 3720 ctacaggcat cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc tccggttccc 3780 aacgatcaag gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt agctccttcg 3840 gtcctccgat cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg gttatggcag 3900 cactgcataa ttctcttact gtcatgccat ccgtaagatg cttttctgtg actggtgagt 3960 actcaaccaa gtcattctga gaatagtgta tgcggcgacc gagttgctct tgcccggcgt 4020 caatacggga taataccgcg ccacatagca gaactttaaa agtgctcatc attggaaaac 4080 gttcttcggg gcgaaaactc tcaaggatct taccgctgtt gagatccagt tcgatgtaac 4140 ccactcgtgc acccaactga tcttcagcat cttttacttt caccagcgtt tctgggtgag 4200 caaaaacagg aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg aaatgttgaa 4260 tactcatact cttccttttt caatattatt gaagcattta tcagggttat tgtctcatga 4320 gcggatacat atttgaatgt atttagaaaa ataaacaaat aggggttccg cgcacatttc 4380 cccgaaaagt gccacctgac gtctaagaaa ccattattat catgacatta acctataaaa 4440 ataggcgtat cacgaggccc tttcgtctcg cgcgtttcgg tgatgacggt gaaaacctct 4500 gacacatgca gctcccggag acggtcacag cttgtctgta agcggatgcc gggagcagac 4560 aagcccgtca gggcgcgtca gcgggtgttg gcgggtgtcg gggctggctt aactatgcgg 4620 catcagagca gattgtactg agagtgcacc atatgcggtg tgaaataccg cacagatgcg 4680 taaggagaaa ataccgcatc aggcgattcc aacatccaat aaatcataca ggcaaggcaa 4740 agaattagca aaattaagca ataaagcctc agagcataaa gctaaatcgg ttgtaccaaa 4800 aacattatga ccctgtaata cttttgcggg agaagccttt atttcaacgc aaggataaaa 4860 atttttagaa ccctcatata ttttaaatgc aatgcctgag taatgtgtag gtaaagattc 4920 aaacgggtga gaaaggccgg agacagtcaa atcaccatca atatgatatt caaccgttct 4980 agctgataaa ttcatgccgg agagggtagc tatttttgag aggtctctac aaaggctatc 5040 aggtcattgc ctgagagtct ggagcaaaca agagaatcga tgaacggtaa tcgtaaaact 5100 agcatgtcaa tcatatgtac cccggttgat aatcagaaaa gccccaaaaa caggaagatt 5160 gtataagcaa atatttaaat tgtaagcgtt aatattttgt taaaattcgc gttaaatttt 5220 tgttaaatca gctcattttt taaccaatag gccgaaatcg gcaaaatccc ttataaatca 5280 aaagaataga ccgagatagg gttgagtgtt gttccagttt ggaacaagag tccactatta 5340 aagaacgtgg actccaacgt caaagggcga aaaaccgtct atcagggcga tggcccacta 5400 cgtgaaccat caccctaatc aagttttttg gggtcgaggt gccgtaaagc actaaatcgg 5460 aaccctaaag ggagcccccg atttagagct tgacggggaa agccggcgaa cgtggcgaga 5520 aaggaaggga agaaagcgaa aggagcgggc gctagggcgc tggcaagtgt agcggtcacg 5580 ctgcgcgtaa ccaccacacc cgccgcgctt aatgcgccgc tacagggcgc gtactatggt 5640 tgctttgacg agcacgtata acgtgctttc ctcgttagaa tcagagcggg agctaaacag 5700 gaggccgatt aaagggattt tagacaggaa cggtacgcca gaatcctgag aagtgttttt 5760 ataatcagtg aggccaccga gtaaaagagt ctgtccatca cgcaaattaa ccgttgtcgc 5820 aatacttctt tgattagtaa taacatcact tgcctgagta gaagaactca aactatcggc 5880 cttgctggta atatccagaa caatattacc gccagccatt gcaacggaat cgccattcgc 5940 cattcaggct gcgcaactgt tgggaagggc gatcggtgcg ggcctcttcg ctattacgcc 6000 agctgcgcgc tcgctcgctc actgaggccg cccgggcaaa gcccgggcgt cgggcgacct 6060 ttggtcgccc ggcctcagtg agcgagcgag cgcgcagaga gggagtggcc aactccatca 6120 ctaggggttc cttgtagtta atgattaacc cgccatgcta cttatctact cgacattgat 6180 tattgactag ttattaatag taatcaatta cggggtcatt agttcatagc ccatatatgg 6240 agttccgcgt tacataactt acggtaaatg gcccgcctgg ctgaccgccc aacgaccccc 6300 gcccattgac gtcaataatg acgtatgttc ccatagtaac gccaataggg actttccatt 6360 gacgtcaatg ggtggagtat ttacggtaaa ctgcccactt ggcagtacat caagtgtatc 6420 atatgccaag tacgccccct attgacgtca atgacggtaa atggcccgcc tggcattatg 6480 cccagtacat gaccttatgg gactttccta cttggcagta catctacgta ttagtcatcg 6540 ctattaccat ggtcgaggtg agccccacgt tctgcttcac tctccccatc tcccccccct 6600 ccccaccccc aattttgtat ttatttattt tttaattatt ttgtgcagcg atgggggcgg 6660 gggggggggg ggggcgcgcg ccaggcgggg cggggcgggg cgaggggcgg ggcggggcga 6720 ggcggagagg tgcggcggca gccaatcaga gcggcgcgct ccgaaagttt ccttttatgg 6780 cgaggcggcg gcggcggcgg ccctataaaa agcgaagcgc gcggcgggcg ggagtcgctg 6840 cgttgccttc gccccgtgcc ccgctccgcc gccgcctcgc gccgcccgcc ccggctctga 6900 ctgaccgcgt tactcccaca ggtgagcggg cgggacggcc cttctcctcc gggctgtaat 6960 tagcgcttgg tttaatgacg gcttgtttct tttctgtggc tgcgtgaaag ccttgagggg 7020 ctccgggagg gccctttgtg cggggggagc ggctcggggg gtgcgtgcgt gtgtgtgtgc 7080 gtggggagcg ccgcgtgcgg ctccgcgctg cccggcggct gtgagcgctg cgggcgcggc 7140 gcggggcttt gtgcgctccg cagtgtgcgc gaggggagcg cggccggggg cggtgccccg 7200 cggtgcgggg ggggctgcga ggggaacaaa ggctgcgtgc ggggtgtgtg cgtggggggg 7260 tgagcagggg gtgtgggcgc gtcggtcggg ctgcaacccc ccctgcaccc ccctccccga 7320 gttgctgagc acggcccggc ttcgggtgcg gggctccgta cggggcgtgg cgcggggctc 7380 gccgtgccgg gcggggggtg gcggcaggtg ggggtgccgg gcggggcggg gccgcctcgg 7440 gccggggagg gctcggggga ggggcgcggc ggcccccgga gcgccggcgg ctgtcgaggc 7500 gcggcgagcc gcagccattg ccttttatgg taatcgtgcg agagggcgca gggacttcct 7560 ttgtcccaaa tctgtgcgga gccgaaatct gggaggcgcc gccgcacccc ctctagcggg 7620 cgcggggcga agcggtgcgg cgccggcagg aaggaaatgg gcggggaggg ccttcgtgcg 7680 tcgccgcgcc gccgtcccct tctccctctc cagcctcggg gctgtccgcg gggggacggc 7740 tgccttcggg ggggacgggg cagggcgggg ttcggcttct ggcgtgtgac cggcggctct 7800 agagcctctg ctaaccatgt tcatgccttc ttctttttcc tacagctcct gggcaacgtg 7860 ctggttattg tgctgtctca tcattttggc aaagaattga ttaattcgag cgaa 7914 <210> 13 <211> 4333 <212> DNA <213> Secuencia Artificial <220> <223> AAV9-CAG-omIDS <400> 13 attacgccag ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg 60 ggcgaccttt ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa 120 ctccatcact aggggttcct tgtagttaat gattaacccg ccatgctact tatctactcg 180 acattgatta ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc 240 atatatggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa 300 cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac 360 tttccattga cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca 420 agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg 480 gcattatgcc cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt 540 agtcatcgct attaccatgg tcgaggtgag ccccacgttc tgcttcactc tccccatctc 600 ccccccctcc ccacccccaa ttttgtattt atttattttt taattatttt gtgcagcgat 660 gggggcgggg gggggggggg ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg 720 cggggcgagg cggagaggtg cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc 780 ttttatggcg aggcggcggc ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcggg 840 agtcgctgcg ttgccttcgc cccgtgcccc gctccgccgc cgcctcgcgc cgcccgcccc 900 ggctctgact gaccgcgtta ctcccacagg tgagcgggcg ggacggccct tctcctccgg 960 gctgtaatta gcgcttggtt taatgacggc ttgtttcttt tctgtggctg cgtgaaagcc 1020 ttgaggggct ccgggagggc cctttgtgcg gggggagcgg ctcggggggt gcgtgcgtgt 1080 gtgtgtgcgt ggggagcgcc gcgtgcggct ccgcgctgcc cggcggctgt gagcgctgcg 1140 ggcgcggcgc ggggctttgt gcgctccgca gtgtgcgcga ggggagcgcg gccgggggcg 1200 gtgccccgcg gtgcgggggg ggctgcgagg ggaacaaagg ctgcgtgcgg ggtgtgtgcg 1260 tgggggggtg agcagggggt gtgggcgcgt cggtcgggct gcaacccccc ctgcaccccc 1320 ctccccgagt tgctgagcac ggcccggctt cgggtgcggg gctccgtacg gggcgtggcg 1380 cggggctcgc cgtgccgggc ggggggtggc ggcaggtggg ggtgccgggc ggggcggggc 1440 cgcctcgggc cggggagggc tcgggggagg ggcgcggcgg cccccggagc gccggcggct 1500 gtcgaggcgc ggcgagccgc agccattgcc ttttatggta atcgtgcgag agggcgcagg 1560 gacttccttt gtcccaaatc tgtgcggagc cgaaatctgg gaggcgccgc cgcaccccct 1620 ctagcgggcg cggggcgaag cggtgcggcg ccggcaggaa ggaaatgggc ggggagggcc 1680 ttcgtgcgtc gccgcgccgc cgtccccttc tccctctcca gcctcggggc tgtccgcggg 1740 gggacggctg ccttcggggg ggacggggca gggcggggtt cggcttctgg cgtgtgaccg 1800 gcggctctag agcctctgct aaccatgttc atgccttctt ctttttccta cagctcctgg 1860 gcaacgtgct ggttattgtg ctgtctcatc attttggcaa agaattgatt aattcgagcg 1920 aacgcgtgct agcgccacca tgagcccacc tcccccaccc ccaatctggc ggcagctgag 1980 cttcagcctg ctgctgggca gcttctgtat cgccctggaa agcgccaagc ttgcccaggg 2040 caacagcgcc accgacgccc tgaacatcct gctgatcatc gtggacgacc tgaggcccag 2100 cctgggatgc tacggcgaca agctggtccg cagccccaac atcgaccagc tggcttctca 2160 cagcgtgctg ttccagaacg cattcgcaca gcaggccgtg tgcgccccca gcagagtgtc 2220 tttcctgacc ggcagaaggc ccgacaccac cagactgtac gacttcaaca gctactggcg 2280 ggtgcacagc ggcaacttca gcaccatccc ccagtacttc aaagaaaacg gctacgtgac 2340 catgagcgtg ggcaaggtgt tccaccccgg catcagcagc aaccacagcg acgactaccc 2400 ctacagctgg tccttcccac cctaccaccc cagcagcgag aagtacgaga acaccaagac 2460 ctgcaagggc caggacggca agctgcacgc caacctgctg tgccctgtgg acgtggcaga 2520 cgtgccagag ggaaccctgc ctgacaagca gagcaccgag gaagccatca gactgctgga 2580 aaagatgaag accagcgcca gccccttctt cctggccgtg ggctaccaca agccccacat 2640 ccctttcaga taccccaaag agttccagaa gctgtacccc ctggaaaaca tcaccctggc 2700 ccccgacccc cacgtgccag attctctgcc ccccgtggcc tacaacccct ggatggatat 2760 ccgcgagcgc gaggacgtgc aggctctgaa catcagcgtg ccctacggcc ctatccccga 2820 ggacttccag agaaagatca gacagagcta cttcgccagc gtgtcctacc tggacaccca 2880 agtgggacac gtgctgagcg ccctggacga tctgagactg gcccacaaca ccatcattgc 2940 cttcaccagc gaccacggct gggctctggg agagcacggc gagtgggcca agtacagcaa 3000 cttcgacgtg gccaccagag tgcccctgat gctgtacgtg cccggcagaa ccgcccctct 3060 gcctgccgct ggacagaagc tgttccctta ccgggacccc ttcgaccccg ccagcgattg 3120 gatggacgcc ggcagacaca ccgaggacct ggtggaactg gtgtccctgt tccccaccct 3180 ggccggactg gctggactgc ctgtgccccc cagatgcccc atccctagct tccacgtcga 3240 actgtgcaga gagggccaga acctgcagaa acatctgcag ctgcacgacc tggaagagga 3300 acccgacctg ttcggcaacc ccagagagct gatcgcctac agccagtacc ccagacccgc 3360 cgacttcccc cagtggaaca gcgacaagcc cagcctgaac gacatcaaag tgatgggcta 3420 cagcatcagg accgtggact acagatacac cgtgtgggtc ggattcgacc ccagcgagtt 3480 cctggccaac ttcagcgaca tccacgccgg cgagctgtac ttcgtggaca gcgaccccct 3540 gcaggaccac aacgtgtaca acgacagcca gcacggcggc ctgctgcaca gcctgaggcc 3600 ttgagcggcc gcgaattcga gctcggtacc cgggaatcaa ttcactcctc aggtgcaggc 3660 tgcctatcag aaggtggtgg ctggtgtggc caatgccctg gctcacaaat accactgaga 3720 tctttttccc tctgccaaaa attatgggga catcatgaag ccccttgagc atctgacttc 3780 tggctaataa aggaaattta ttttcattgc aatagtgtgt tggaattttt tgtgtctctc 3840 actcggaagg acatatggga gggcaaatca tttaaaacat cagaatgagt atttggttta 3900 gagtttggca acatatgccc atatgctggc tgccatgaac aaaggttggc tataaagagg 3960 tcatcagtat atgaaacagc cccctgctgt ccattcctta ttccatagaa aagccttgac 4020 ttgaggttag atttttttta tattttgttt tgtgttattt ttttctttaa catccctaaa 4080 attttcctta catgttttac tagccagatt tttcctcctc tcctgactac tcccagtcat 4140 agctgtccct cttctcttat ggagatccct cgacctgcag cccaagctgt agataagtag 4200 catggcgggt taatcattaa ctacaaggaa cccctagtga tggagttggc cactccctct 4260 ctgcgcgctc gctcgctcac tgaggccgcc cgggctttgc ccgggcggcc tcagtgagcg 4320 agcgagcgcg cag 4333 <210> 14 <211> 646 <212> DNA <213> Secuencia Artificial <220> <223> Promotor CAG <400> 14 actagttatt aatagtaatc aattacgggg tcattagttc atagcccata tatggagttc 60 cgcgttacat aacttacggt aaatggcccg cctggctgac cgcccaacga cccccgccca 120 ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt ccattgacgt 180 caatgggtgg agtatttacg gtaaactgcc cacttggcag tacatcaagt gtatcatatg 240 ccaagtacgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag 300 tacatgacct tatgggactt tcctacttgg cagtacatct acgtattagt catcgctatt 360 accatggtcg aggtgagccc cacgttctgc ttcactctcc ccatctcccc cccctcccca 420 cccccaattt tgtatttatt tattttttaa ttattttgtg cagcgatggg ggcggggggg 480 gggggggggc gcgcgccagg cggggcgggg cggggcgagg ggcggggcgg ggcgaggcgg 540 agaggtgcgg cggcagccaa tcagagcggc gcgctccgaa agtttccttt tatggcgagg 600 cggcggcggc ggcggcccta taaaaagcga agcgcgcggc gggcgg 646 <210> 15 <211> 20 <212> DNA <213> Secuencia Artificial <220> <223> cebador directo <400> 15 ttttgtgtac tccaaccccg 20 <210> 16 <211> 20 <212> DNA <213> Secuencia Artificial <220> <223> Cebador inverso <400> 16 tgtctgcata acagcccagg 20 <210> 17 <211> 20 <212> DNA <213> Secuencia Artificial <220> <223> Mutación del cebador inverso <400> 17 gccctcacat tgccaaagga 20 <210> 18 <211> 25 <212> DNA <213> Secuencia Artificial <220> <223> Cebador directo para la secuencia HBB2 <400> 18 cttgagcatc tgacttctgg ctaat 25 <210> 19 <211> 21 <212> DNA <213> Secuencia Artificial <220> <223> Cebador inverso para la secuencia HBB2 <400> 19 gatttgccct cccatatgtc c 21 <210> 20 <211> 30 <212> DNA <213> Secuencia Artificial <220> <223> Sonda para la secuencia HBB2 <400> 20 ccgagtgaga gacacaaaaa attccaacac 30