LISTADO DE SECUENCIAS <110> I-MAB <120> ANTICUERPOS ANTI-CD73 Y USOS DE LOS MISMOS <130> 54LW-250265-WO2 <150> PCT/CN2017/072445 <151> 2017-01-24 <160> 61 <170> PatentIn version 3.5 <210> 1 <211> 6 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 1 Ser Gly Tyr Tyr Trp Asn 1 5 <210> 2 <211> 16 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 2 Tyr Ile Asn Tyr Gly Gly Ser Asn Gly Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 3 <211> 11 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 3 Asp Tyr Asp Ala Tyr Tyr Glu Ala Leu Asp Asp 1 5 10 <210> 4 <211> 10 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 4 Arg Ala Ser Ser Arg Val Asn Tyr Met His 1 5 10 <210> 5 <211> 7 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 5 Ala Thr Ser Asn Leu Ala Ser 1 5 <210> 6 <211> 9 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 6 Gln Gln Trp Ser Ser Asn Pro Pro Thr 1 5 <210> 7 <211> 50 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 7 Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Thr Ser Gly 20 25 30 Tyr Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Lys Leu Glu Trp 35 40 45 Met Gly 50 <210> 8 <211> 50 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 8 Glu Ile Val Leu Ser Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Ser Arg Val Asn Tyr Met 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Arg Pro Trp Ile Ser 35 40 45 Ala Thr 50 <210> 9 <211> 50 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 9 Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 20 25 30 Tyr Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Gly 50 <210> 10 <211> 50 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 10 Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 1 5 10 15 Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 20 25 30 Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 35 40 45 Met Gly 50 <210> 11 <211> 50 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 11 Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 20 25 30 Tyr Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Gly 50 <210> 12 <211> 50 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 12 Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 20 25 30 Tyr Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Gly 50 <210> 13 <211> 50 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 13 Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 20 25 30 Tyr Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 35 40 45 Met Gly 50 <210> 14 <211> 50 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 14 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 20 25 30 Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Gly 50 <210> 15 <211> 50 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 15 Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 1 5 10 15 Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Arg Val Asn Tyr Met 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Ser 35 40 45 Ala Thr 50 <210> 16 <211> 50 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 16 Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 1 5 10 15 Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Ser Arg Val Asn Tyr Met 20 25 30 His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile Lys 35 40 45 Ala Thr 50 <210> 17 <211> 50 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 17 Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 1 5 10 15 Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Ser Arg Val Asn Tyr Met 20 25 30 His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile Lys 35 40 45 Ala Thr 50 <210> 18 <211> 50 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 18 Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 1 5 10 15 Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Ser Arg Val Asn Tyr Met 20 25 30 His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile Ser 35 40 45 Ala Thr 50 <210> 19 <211> 50 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 19 Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 1 5 10 15 Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Ser Arg Val Asn Tyr Met 20 25 30 His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Pro Trp Ile Ser 35 40 45 Ala Thr 50 <210> 20 <211> 50 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 20 Glu Ile Val Leu Ser Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 1 5 10 15 Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Ser Arg Val Asn Tyr Met 20 25 30 His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Pro Trp Ile Ser 35 40 45 Ala Thr 50 <210> 21 <211> 51 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 21 Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 1 5 10 15 Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Ser Ser 20 25 30 Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 35 40 45 Lys Tyr Ala 50 <210> 22 <211> 50 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 22 Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Ser Arg Val Asn Tyr Met 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 35 40 45 Ala Thr 50 <210> 23 <211> 50 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 23 Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Ser Arg Val Asn Tyr Met 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 35 40 45 Ala Thr 50 <210> 24 <211> 50 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 24 Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Ser Arg Val Asn Tyr Met 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Ser 35 40 45 Ala Thr 50 <210> 25 <211> 51 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 25 Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala 50 <210> 26 <211> 6 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 26 Thr Gly Tyr Tyr Trp Asn 1 5 <210> 27 <211> 6 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 27 Cys Gly Tyr Tyr Trp Asn 1 5 <210> 28 <211> 6 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 28 Ser Ala Tyr Tyr Trp Asn 1 5 <210> 29 <211> 6 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 29 Ser Pro Tyr Tyr Trp Asn 1 5 <210> 30 <211> 16 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 30 Tyr Ile Asn Tyr Gly Ala Ser Asn Gly Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 31 <211> 16 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 31 Tyr Ile Asn Tyr Gly Pro Ser Asn Gly Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 32 <211> 16 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 32 Tyr Ile Asn Tyr Gly Gly Thr Asn Gly Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 33 <211> 16 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 33 Tyr Ile Asn Tyr Gly Gly Cys Asn Gly Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 34 <211> 16 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 34 Tyr Ile Asn Tyr Gly Gly Ser Asp Gly Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 35 <211> 16 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 35 Tyr Ile Asn Tyr Gly Gly Ser Glu Gly Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 36 <211> 16 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 36 Tyr Ile Asn Tyr Gly Gly Ser Gln Gly Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 37 <211> 11 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 37 Asp Tyr Asp Ala Tyr Tyr Asp Ala Leu Asp Asp 1 5 10 <210> 38 <211> 11 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 38 Asp Tyr Asp Ala Tyr Tyr Gln Ala Leu Asp Asp 1 5 10 <210> 39 <211> 11 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 39 Asp Tyr Asp Ala Tyr Tyr Asn Ala Leu Asp Asp 1 5 10 <210> 40 <211> 11 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 40 Asp Tyr Asp Ala Tyr Tyr Glu Gly Leu Asp Asp 1 5 10 <210> 41 <211> 11 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 41 Asp Tyr Asp Ala Tyr Tyr Glu Cys Leu Asp Asp 1 5 10 <210> 42 <211> 10 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 42 Arg Ala Thr Ser Arg Val Asn Tyr Met His 1 5 10 <210> 43 <211> 10 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 43 Arg Ala Cys Ser Arg Val Asn Tyr Met His 1 5 10 <210> 44 <211> 10 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 44 Arg Ala Ser Thr Arg Val Asn Tyr Met His 1 5 10 <210> 45 <211> 10 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 45 Arg Ala Ser Cys Arg Val Asn Tyr Met His 1 5 10 <210> 46 <211> 9 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 46 Asn Gln Trp Ser Ser Asn Pro Pro Thr 1 5 <210> 47 <211> 9 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 47 Asp Gln Trp Ser Ser Asn Pro Pro Thr 1 5 <210> 48 <211> 9 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 48 Glu Gln Trp Ser Ser Asn Pro Pro Thr 1 5 <210> 49 <211> 9 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 49 Gln Asn Trp Ser Ser Asn Pro Pro Thr 1 5 <210> 50 <211> 9 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 50 Gln Asp Trp Ser Ser Asn Pro Pro Thr 1 5 <210> 51 <211> 9 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 51 Gln Glu Trp Ser Ser Asn Pro Pro Thr 1 5 <210> 52 <211> 9 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 52 Gln Gln Tyr Ser Ser Asn Pro Pro Thr 1 5 <210> 53 <211> 9 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 53 Gln Gln Trp Thr Ser Asn Pro Pro Thr 1 5 <210> 54 <211> 9 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 54 Gln Gln Trp Cys Ser Asn Pro Pro Thr 1 5 <210> 55 <211> 9 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 55 Gln Gln Trp Ser Thr Asn Pro Pro Thr 1 5 <210> 56 <211> 9 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 56 Gln Gln Trp Ser Cys Asn Pro Pro Thr 1 5 <210> 57 <211> 360 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 57 Gly Ala Thr Gly Thr Ala Cys Ala Gly Cys Thr Thr Cys Ala Gly Gly 1 5 10 15 Ala Gly Thr Cys Ala Gly Gly Ala Cys Cys Thr Gly Gly Cys Cys Thr 20 25 30 Cys Gly Thr Gly Ala Ala Ala Cys Cys Thr Thr Cys Thr Cys Ala Gly 35 40 45 Thr Cys Thr Cys Thr Gly Thr Cys Thr Cys Thr Cys Ala Cys Cys Thr 50 55 60 Gly Cys Thr Cys Thr Gly Thr Cys Ala Cys Thr Gly Gly Cys Thr Ala 65 70 75 80 Cys Thr Cys Cys Ala Thr Cys Ala Cys Cys Ala Gly Thr Gly Gly Thr 85 90 95 Thr Ala Thr Thr Ala Cys Thr Gly Gly Ala Ala Cys Thr Gly Gly Ala 100 105 110 Thr Cys Cys Gly Gly Cys Ala Gly Thr Thr Thr Cys Cys Ala Gly Gly 115 120 125 Ala Ala Ala Cys Ala Ala Ala Cys Thr Gly Gly Ala Ala Thr Gly Gly 130 135 140 Ala Thr Gly Gly Gly Cys Thr Ala Cys Ala Thr Ala Ala Ala Cys Thr 145 150 155 160 Ala Cys Gly Gly Cys Gly Gly Thr Ala Gly Cys Ala Ala Thr Gly Gly 165 170 175 Cys Thr Ala Cys Ala Ala Cys Cys Cys Ala Thr Cys Thr Cys Thr Cys 180 185 190 Ala Ala Ala Ala Gly Thr Cys Gly Gly Ala Thr Cys Thr Cys Cys Ala 195 200 205 Thr Cys Ala Cys Thr Cys Gly Gly Gly Ala Cys Ala Cys Ala Thr Cys 210 215 220 Thr Ala Ala Gly Ala Ala Cys Cys Ala Gly Thr Thr Thr Thr Thr Cys 225 230 235 240 Cys Thr Gly Ala Ala Gly Cys Thr Gly Ala Ala Thr Thr Cys Thr Gly 245 250 255 Thr Gly Ala Cys Thr Ala Cys Thr Gly Ala Gly Gly Ala Cys Ala Cys 260 265 270 Ala Gly Cys Thr Ala Cys Ala Thr Ala Thr Thr Ala Cys Thr Gly Thr 275 280 285 Gly Cys Ala Ala Gly Ala Gly Ala Cys Thr Ala Thr Gly Ala Thr Gly 290 295 300 Gly Thr Thr Ala Cys Thr Ala Cys Gly Ala Ala Gly Cys Thr Cys Thr 305 310 315 320 Gly Gly Ala Cys Gly Ala Cys Thr Gly Gly Gly Gly Thr Cys Ala Ala 325 330 335 Gly Gly Ala Ala Cys Cys Thr Cys Ala Gly Thr Cys Ala Cys Cys Gly 340 345 350 Thr Cys Thr Cys Cys Thr Cys Ala 355 360 <210> 58 <211> 318 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 58 Cys Ala Ala Ala Thr Thr Gly Thr Thr Cys Thr Cys Thr Cys Cys Cys 1 5 10 15 Ala Gly Thr Cys Thr Cys Cys Ala Gly Cys Ala Ala Thr Cys Cys Thr 20 25 30 Gly Thr Cys Thr Gly Cys Ala Thr Cys Thr Cys Cys Ala Gly Gly Gly 35 40 45 Gly Ala Gly Ala Ala Gly Gly Thr Cys Ala Cys Ala Ala Thr Gly Ala 50 55 60 Cys Thr Thr Gly Cys Ala Gly Gly Gly Cys Cys Ala Gly Cys Thr Cys 65 70 75 80 Ala Cys Gly Thr Gly Thr Ala Ala Ala Thr Thr Ala Cys Ala Thr Gly 85 90 95 Cys Ala Cys Thr Gly Gly Thr Ala Cys Cys Ala Gly Cys Ala Gly Ala 100 105 110 Ala Gly Cys Cys Ala Gly Gly Ala Thr Cys Cys Thr Cys Cys Cys Cys 115 120 125 Cys Ala Ala Ala Cys Cys Cys Thr Gly Gly Ala Thr Thr Thr Cys Thr 130 135 140 Gly Cys Cys Ala Cys Ala Thr Cys Cys Ala Ala Cys Cys Thr Gly Gly 145 150 155 160 Cys Thr Thr Cys Thr Gly Gly Ala Gly Thr Cys Cys Cys Thr Gly Cys 165 170 175 Thr Cys Gly Cys Thr Thr Cys Ala Gly Thr Gly Gly Cys Ala Gly Thr 180 185 190 Gly Gly Gly Thr Cys Thr Gly Gly Gly Ala Cys Cys Thr Cys Thr Thr 195 200 205 Ala Cys Thr Cys Thr Cys Thr Cys Ala Cys Ala Ala Thr Thr Ala Gly 210 215 220 Cys Ala Gly Ala Gly Thr Ala Gly Ala Gly Ala Cys Thr Gly Ala Ala 225 230 235 240 Gly Ala Thr Gly Cys Thr Gly Cys Cys Ala Cys Thr Thr Ala Thr Thr 245 250 255 Ala Cys Thr Gly Cys Cys Ala Gly Cys Ala Gly Thr Gly Gly Ala Gly 260 265 270 Thr Ala Gly Thr Ala Ala Cys Cys Cys Ala Cys Cys Cys Ala Cys Gly 275 280 285 Thr Thr Cys Gly Gly Ala Gly Gly Gly Gly Gly Gly Ala Cys Cys Ala 290 295 300 Ala Gly Cys Thr Gly Gly Ala Ala Ala Thr Ala Ala Ala Ala 305 310 315 <210> 59 <211> 360 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 59 Gly Ala Gly Gly Thr Ala Cys Ala Gly Cys Thr Thr Cys Ala Gly Gly 1 5 10 15 Ala Gly Thr Cys Ala Gly Gly Ala Cys Cys Thr Gly Gly Cys Cys Thr 20 25 30 Cys Gly Thr Gly Ala Ala Ala Cys Cys Thr Thr Cys Thr Gly Ala Gly 35 40 45 Ala Cys Thr Cys Thr Gly Thr Cys Thr Cys Thr Cys Ala Cys Cys Thr 50 55 60 Gly Cys Gly Cys Thr Gly Thr Cys Thr Cys Thr Gly Gly Cys Thr Ala 65 70 75 80 Cys Thr Cys Cys Ala Thr Cys Ala Cys Cys Ala Gly Thr Gly Gly Thr 85 90 95 Thr Ala Thr Thr Ala Cys Thr Gly Gly Ala Ala Cys Thr Gly Gly Ala 100 105 110 Thr Cys Cys Gly Gly Cys Ala Gly Cys Cys Thr Cys Cys Ala Gly Gly 115 120 125 Ala Ala Ala Gly Ala Ala Gly Cys Thr Gly Gly Ala Ala Thr Gly Gly 130 135 140 Ala Thr Gly Gly Gly Cys Thr Ala Cys Ala Thr Cys Ala Ala Cys Thr 145 150 155 160 Ala Cys Gly Gly Cys Gly Gly Thr Ala Gly Cys Ala Ala Thr Gly Gly 165 170 175 Cys Thr Ala Cys Ala Ala Cys Cys Cys Ala Thr Cys Thr Cys Thr Cys 180 185 190 Ala Ala Ala Ala Gly Thr Cys Gly Gly Ala Thr Cys Ala Cys Cys Ala 195 200 205 Thr Cys Thr Cys Thr Ala Gly Gly Gly Ala Cys Ala Cys Ala Thr Cys 210 215 220 Thr Ala Ala Gly Ala Ala Cys Cys Ala Gly Thr Thr Thr Thr Cys Cys 225 230 235 240 Cys Thr Gly Ala Ala Gly Cys Thr Gly Ala Gly Thr Thr Cys Thr Gly 245 250 255 Thr Gly Ala Cys Thr Gly Cys Thr Gly Cys Cys Gly Ala Cys Ala Cys 260 265 270 Ala Gly Cys Thr Gly Thr Gly Thr Ala Thr Thr Ala Cys Thr Gly Thr 275 280 285 Gly Cys Ala Ala Gly Ala Gly Ala Cys Thr Ala Thr Gly Ala Thr Gly 290 295 300 Cys Thr Thr Ala Cys Thr Ala Cys Gly Ala Ala Gly Cys Thr Cys Thr 305 310 315 320 Gly Gly Ala Cys Gly Ala Cys Thr Gly Gly Gly Gly Thr Cys Ala Ala 325 330 335 Gly Gly Ala Ala Cys Cys Ala Cys Ala Gly Thr Cys Ala Cys Cys Gly 340 345 350 Thr Cys Thr Cys Cys Thr Cys Ala 355 360 <210> 60 <211> 318 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 60 Gly Ala Ala Ala Thr Thr Gly Thr Thr Cys Thr Cys Thr Cys Cys Cys 1 5 10 15 Ala Gly Thr Cys Thr Cys Cys Ala Gly Cys Ala Ala Cys Cys Cys Thr 20 25 30 Gly Thr Cys Thr Cys Thr Gly Thr Cys Thr Cys Cys Ala Gly Gly Gly 35 40 45 Gly Ala Gly Ala Gly Gly Gly Cys Cys Ala Cys Ala Cys Thr Gly Thr 50 55 60 Cys Thr Thr Gly Cys Ala Gly Gly Gly Cys Cys Ala Gly Cys Thr Cys 65 70 75 80 Ala Cys Gly Thr Gly Thr Ala Ala Ala Thr Thr Ala Cys Ala Thr Gly 85 90 95 Cys Ala Cys Thr Gly Gly Thr Ala Cys Cys Ala Gly Cys Ala Gly Ala 100 105 110 Ala Gly Cys Cys Ala Gly Gly Ala Cys Ala Gly Thr Cys Cys Cys Cys 115 120 125 Cys Ala Gly Ala Cys Cys Cys Thr Gly Gly Ala Thr Thr Thr Cys Thr 130 135 140 Gly Cys Cys Ala Cys Ala Thr Cys Cys Ala Ala Cys Cys Thr Gly Gly 145 150 155 160 Cys Thr Thr Cys Thr Gly Gly Ala Gly Thr Cys Cys Cys Thr Gly Cys 165 170 175 Thr Cys Gly Cys Thr Thr Cys Ala Gly Thr Gly Gly Cys Ala Gly Thr 180 185 190 Gly Gly Gly Thr Cys Thr Gly Gly Gly Ala Cys Cys Thr Cys Thr Thr 195 200 205 Ala Cys Ala Cys Thr Cys Thr Cys Ala Cys Ala Ala Thr Thr Ala Gly 210 215 220 Cys Ala Gly Cys Cys Thr Gly Gly Ala Gly Cys Cys Ala Gly Ala Ala 225 230 235 240 Gly Ala Thr Thr Thr Cys Gly Cys Cys Gly Thr Gly Thr Ala Thr Thr 245 250 255 Ala Cys Thr Gly Cys Cys Ala Gly Cys Ala Gly Thr Gly Gly Ala Gly 260 265 270 Thr Ala Gly Thr Ala Ala Cys Cys Cys Ala Cys Cys Cys Ala Cys Gly 275 280 285 Thr Thr Cys Gly Gly Ala Gly Gly Gly Gly Gly Gly Ala Cys Cys Ala 290 295 300 Ala Gly Gly Thr Gly Gly Ala Ala Ala Thr Cys Ala Ala Ala 305 310 315 <210> 61 <211> 574 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 61 Met Cys Pro Arg Ala Ala Arg Ala Pro Ala Thr Leu Leu Leu Ala Leu 1 5 10 15 Gly Ala Val Leu Trp Pro Ala Ala Gly Ala Trp Glu Leu Thr Ile Leu 20 25 30 His Thr Asn Asp Val His Ser Arg Leu Glu Gln Thr Ser Glu Asp Ser 35 40 45 Ser Lys Cys Val Asn Ala Ser Arg Cys Met Gly Gly Val Ala Arg Leu 50 55 60 Phe Thr Lys Val Gln Gln Ile Arg Arg Ala Glu Pro Asn Val Leu Leu 65 70 75 80 Leu Asp Ala Gly Asp Gln Tyr Gln Gly Thr Ile Trp Phe Thr Val Tyr 85 90 95 Lys Gly Ala Glu Val Ala His Phe Met Asn Ala Leu Arg Tyr Asp Ala 100 105 110 Met Ala Leu Gly Asn His Glu Phe Asp Asn Gly Val Glu Gly Leu Ile 115 120 125 Glu Pro Leu Leu Lys Glu Ala Lys Phe Pro Ile Leu Ser Ala Asn Ile 130 135 140 Lys Ala Lys Gly Pro Leu Ala Ser Gln Ile Ser Gly Leu Tyr Leu Pro 145 150 155 160 Tyr Lys Val Leu Pro Val Gly Asp Glu Val Val Gly Ile Val Gly Tyr 165 170 175 Thr Ser Lys Glu Thr Pro Phe Leu Ser Asn Pro Gly Thr Asn Leu Val 180 185 190 Phe Glu Asp Glu Ile Thr Ala Leu Gln Pro Glu Val Asp Lys Leu Lys 195 200 205 Thr Leu Asn Val Asn Lys Ile Ile Ala Leu Gly His Ser Gly Phe Glu 210 215 220 Met Asp Lys Leu Ile Ala Gln Lys Val Arg Gly Val Asp Val Val Val 225 230 235 240 Gly Gly His Ser Asn Thr Phe Leu Tyr Thr Gly Asn Pro Pro Ser Lys 245 250 255 Glu Val Pro Ala Gly Lys Tyr Pro Phe Ile Val Thr Ser Asp Asp Gly 260 265 270 Arg Lys Val Pro Val Val Gln Ala Tyr Ala Phe Gly Lys Tyr Leu Gly 275 280 285 Tyr Leu Lys Ile Glu Phe Asp Glu Arg Gly Asn Val Ile Ser Ser His 290 295 300 Gly Asn Pro Ile Leu Leu Asn Ser Ser Ile Pro Glu Asp Pro Ser Ile 305 310 315 320 Lys Ala Asp Ile Asn Lys Trp Arg Ile Lys Leu Asp Asn Tyr Ser Thr 325 330 335 Gln Glu Leu Gly Lys Thr Ile Val Tyr Leu Asp Gly Ser Ser Gln Ser 340 345 350 Cys Arg Phe Arg Glu Cys Asn Met Gly Asn Leu Ile Cys Asp Ala Met 355 360 365 Ile Asn Asn Asn Leu Arg His Thr Asp Glu Met Phe Trp Asn His Val 370 375 380 Ser Met Cys Ile Leu Asn Gly Gly Gly Ile Arg Ser Pro Ile Asp Glu 385 390 395 400 Arg Asn Asn Gly Thr Ile Thr Trp Glu Asn Leu Ala Ala Val Leu Pro 405 410 415 Phe Gly Gly Thr Phe Asp Leu Val Gln Leu Lys Gly Ser Thr Leu Lys 420 425 430 Lys Ala Phe Glu His Ser Val His Arg Tyr Gly Gln Ser Thr Gly Glu 435 440 445 Phe Leu Gln Val Gly Gly Ile His Val Val Tyr Asp Leu Ser Arg Lys 450 455 460 Pro Gly Asp Arg Val Val Lys Leu Asp Val Leu Cys Thr Lys Cys Arg 465 470 475 480 Val Pro Ser Tyr Asp Pro Leu Lys Met Asp Glu Val Tyr Lys Val Ile 485 490 495 Leu Pro Asn Phe Leu Ala Asn Gly Gly Asp Gly Phe Gln Met Ile Lys 500 505 510 Asp Glu Leu Leu Arg His Asp Ser Gly Asp Gln Asp Ile Asn Val Val 515 520 525 Ser Thr Tyr Ile Ser Lys Met Lys Val Ile Tyr Pro Ala Val Glu Gly 530 535 540 Arg Ile Lys Phe Ser Thr Gly Ser His Cys His Gly Ser Phe Ser Leu 545 550 555 560 Ile Phe Leu Ser Leu Trp Ala Val Ile Phe Val Leu Tyr Gln 565 570