SEQUENCE LISTING <110> Berlin-Chemie AG <120> Pharmaceutical combinations <130> 489.131183/01 <160> 207 <170> PatentIn version 3.5 <210> 1 <211> 119 <212> PRT <213> Human <400> 1 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Tyr Ser Asn Ala 20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala 50 55 60 Pro Val Gln Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Thr Ile Phe Gly Val Val Ser Phe Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 2 <211> 108 <212> PRT <213> Human <400> 2 Asp Val Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asp Tyr 20 25 30 Leu Ser Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Asn Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Asn Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Thr Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Arg Ser Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3 <211> 357 <212> DNA <213> Human <400> 3 gaggtgcagc tggtggagtc tgggggaggc ttggtaaagc cgggggggtc ccttagactc 60 tcctgtgcag cctctggctt cacttacagt aacgcctgga tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggttggccgt attaaaagca aaactgatgg tgggacaaca 180 gactacgctg cacccgtgca aggcagattc accatctcaa gagatgattc aaaaaacacg 240 ctgtatctgc aaatgaacag cctgaaaacc gaggacacag ccgtgtatta ctgtacgatt 300 tttggagtgg ttagctttga ctactggggc cagggaaccc tggtcaccgt ctcctca 357 <210> 4 <211> 324 <212> DNA <213> Human <400> 4 gacgtccaga tgacccagtc tccatcctcc ctgtctgcat ctgttggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattagc gactatttaa gttggtatca gcagagacca 120 gggaaagccc ctaacctcct gatctatgct gcatccaatt taaagactgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcac tctgcaacct 240 gaagattttg caacgtacta ctgtcaacag agttacaggt ccccgtggac gttcggccaa 300 gggaccaagg tggaaatcaa acga 324 <210> 5 <211> 5 <212> PRT <213> Human <400> 5 Asn Ala Trp Met Ser 1 5 <210> 6 <211> 19 <212> PRT <213> Human <400> 6 Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala Pro 1 5 10 15 Val Gln Gly <210> 7 <211> 8 <212> PRT <213> Human <400> 7 Phe Gly Val Val Ser Phe Asp Tyr 1 5 <210> 8 <211> 11 <212> PRT <213> Human <400> 8 Arg Ala Ser Gln Ser Ile Ser Asp Tyr Leu Ser 1 5 10 <210> 9 <211> 7 <212> PRT <213> Human <400> 9 Ala Ala Ser Asn Leu Lys Thr 1 5 <210> 10 <211> 9 <212> PRT <213> Human <400> 10 Gln Gln Ser Tyr Arg Ser Pro Trp Thr 1 5 <210> 11 <211> 104 <212> PRT <213> Human <400> 11 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala 50 55 60 Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Thr Thr Thr Thr Val Thr 100 <210> 12 <211> 15 <212> PRT <213> Human <400> 12 Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 1 5 10 15 <210> 13 <211> 93 <212> PRT <213> Human <400> 13 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser 85 90 <210> 14 <211> 13 <212> PRT <213> Human <400> 14 Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 1 5 10 <210> 15 <211> 1722 <212> PRT <213> Human <400> 15 Met Arg Thr Gly Trp Ala Thr Pro Arg Arg Pro Ala Gly Leu Leu Met 1 5 10 15 Leu Leu Phe Trp Phe Phe Asp Leu Ala Glu Pro Ser Gly Arg Ala Ala 20 25 30 Asn Asp Pro Phe Thr Ile Val His Gly Asn Thr Gly Lys Cys Ile Lys 35 40 45 Pro Val Tyr Gly Trp Ile Val Ala Asp Asp Cys Asp Glu Thr Glu Asp 50 55 60 Lys Leu Trp Lys Trp Val Ser Gln His Arg Leu Phe His Leu His Ser 65 70 75 80 Gln Lys Cys Leu Gly Leu Asp Ile Thr Lys Ser Val Asn Glu Leu Arg 85 90 95 Met Phe Ser Cys Asp Ser Ser Ala Met Leu Trp Trp Lys Cys Glu His 100 105 110 His Ser Leu Tyr Gly Ala Ala Arg Tyr Arg Leu Ala Leu Lys Asp Gly 115 120 125 His Gly Thr Ala Ile Ser Asn Ala Ser Asp Val Trp Lys Lys Gly Gly 130 135 140 Ser Glu Glu Ser Leu Cys Asp Gln Pro Tyr His Glu Ile Tyr Thr Arg 145 150 155 160 Asp Gly Asn Ser Tyr Gly Arg Pro Cys Glu Phe Pro Phe Leu Ile Asp 165 170 175 Gly Thr Trp His His Asp Cys Ile Leu Asp Glu Asp His Ser Gly Pro 180 185 190 Trp Cys Ala Thr Thr Leu Asn Tyr Glu Tyr Asp Arg Lys Trp Gly Ile 195 200 205 Cys Leu Lys Pro Glu Asn Gly Cys Glu Asp Asn Trp Glu Lys Asn Glu 210 215 220 Gln Phe Gly Ser Cys Tyr Gln Phe Asn Thr Gln Thr Ala Leu Ser Trp 225 230 235 240 Lys Glu Ala Tyr Val Ser Cys Gln Asn Gln Gly Ala Asp Leu Leu Ser 245 250 255 Ile Asn Ser Ala Ala Glu Leu Thr Tyr Leu Lys Glu Lys Glu Gly Ile 260 265 270 Ala Lys Ile Phe Trp Ile Gly Leu Asn Gln Leu Tyr Ser Ala Arg Gly 275 280 285 Trp Glu Trp Ser Asp His Lys Pro Leu Asn Phe Leu Asn Trp Asp Pro 290 295 300 Asp Arg Pro Ser Ala Pro Thr Ile Gly Gly Ser Ser Cys Ala Arg Met 305 310 315 320 Asp Ala Glu Ser Gly Leu Trp Gln Ser Phe Ser Cys Glu Ala Gln Leu 325 330 335 Pro Tyr Val Cys Arg Lys Pro Leu Asn Asn Thr Val Glu Leu Thr Asp 340 345 350 Val Trp Thr Tyr Ser Asp Thr Arg Cys Asp Ala Gly Trp Leu Pro Asn 355 360 365 Asn Gly Phe Cys Tyr Leu Leu Val Asn Glu Ser Asn Ser Trp Asp Lys 370 375 380 Ala His Ala Lys Cys Lys Ala Phe Ser Ser Asp Leu Ile Ser Ile His 385 390 395 400 Ser Leu Ala Asp Val Glu Val Val Val Thr Lys Leu His Asn Glu Asp 405 410 415 Ile Lys Glu Glu Val Trp Ile Gly Leu Lys Asn Ile Asn Ile Pro Thr 420 425 430 Leu Phe Gln Trp Ser Asp Gly Thr Glu Val Thr Leu Thr Tyr Trp Asp 435 440 445 Glu Asn Glu Pro Asn Val Pro Tyr Asn Lys Thr Pro Asn Cys Val Ser 450 455 460 Tyr Leu Gly Glu Leu Gly Gln Trp Lys Val Gln Ser Cys Glu Glu Lys 465 470 475 480 Leu Lys Tyr Val Cys Lys Arg Lys Gly Glu Lys Leu Asn Asp Ala Ser 485 490 495 Ser Asp Lys Met Cys Pro Pro Asp Glu Gly Trp Lys Arg His Gly Glu 500 505 510 Thr Cys Tyr Lys Ile Tyr Glu Asp Glu Val Pro Phe Gly Thr Asn Cys 515 520 525 Asn Leu Thr Ile Thr Ser Arg Phe Glu Gln Glu Tyr Leu Asn Asp Leu 530 535 540 Met Lys Lys Tyr Asp Lys Ser Leu Arg Lys Tyr Phe Trp Thr Gly Leu 545 550 555 560 Arg Asp Val Asp Ser Cys Gly Glu Tyr Asn Trp Ala Thr Val Gly Gly 565 570 575 Arg Arg Arg Ala Val Thr Phe Ser Asn Trp Asn Phe Leu Glu Pro Ala 580 585 590 Ser Pro Gly Gly Cys Val Ala Met Ser Thr Gly Lys Ser Val Gly Lys 595 600 605 Trp Glu Val Lys Asp Cys Arg Ser Phe Lys Ala Leu Ser Ile Cys Lys 610 615 620 Lys Met Ser Gly Pro Leu Gly Pro Glu Glu Ala Ser Pro Lys Pro Asp 625 630 635 640 Asp Pro Cys Pro Glu Gly Trp Gln Ser Phe Pro Ala Ser Leu Ser Cys 645 650 655 Tyr Lys Val Phe His Ala Glu Arg Ile Val Arg Lys Arg Asn Trp Glu 660 665 670 Glu Ala Glu Arg Phe Cys Gln Ala Leu Gly Ala His Leu Ser Ser Phe 675 680 685 Ser His Val Asp Glu Ile Lys Glu Phe Leu His Phe Leu Thr Asp Gln 690 695 700 Phe Ser Gly Gln His Trp Leu Trp Ile Gly Leu Asn Lys Arg Ser Pro 705 710 715 720 Asp Leu Gln Gly Ser Trp Gln Trp Ser Asp Arg Thr Pro Val Ser Thr 725 730 735 Ile Ile Met Pro Asn Glu Phe Gln Gln Asp Tyr Asp Ile Arg Asp Cys 740 745 750 Ala Ala Val Lys Val Phe His Arg Pro Trp Arg Arg Gly Trp His Phe 755 760 765 Tyr Asp Asp Arg Glu Phe Ile Tyr Leu Arg Pro Phe Ala Cys Asp Thr 770 775 780 Lys Leu Glu Trp Val Cys Gln Ile Pro Lys Gly Arg Thr Pro Lys Thr 785 790 795 800 Pro Asp Trp Tyr Asn Pro Asp Arg Ala Gly Ile His Gly Pro Pro Leu 805 810 815 Ile Ile Glu Gly Ser Glu Tyr Trp Phe Val Ala Asp Leu His Leu Asn 820 825 830 Tyr Glu Glu Ala Val Leu Tyr Cys Ala Ser Asn His Ser Phe Leu Ala 835 840 845 Thr Ile Thr Ser Phe Val Gly Leu Lys Ala Ile Lys Asn Lys Ile Ala 850 855 860 Asn Ile Ser Gly Asp Gly Gln Lys Trp Trp Ile Arg Ile Ser Glu Trp 865 870 875 880 Pro Ile Asp Asp His Phe Thr Tyr Ser Arg Tyr Pro Trp His Arg Phe 885 890 895 Pro Val Thr Phe Gly Glu Glu Cys Leu Tyr Met Ser Ala Lys Thr Trp 900 905 910 Leu Ile Asp Leu Gly Lys Pro Thr Asp Cys Ser Thr Lys Leu Pro Phe 915 920 925 Ile Cys Glu Lys Tyr Asn Val Ser Ser Leu Glu Lys Tyr Ser Pro Asp 930 935 940 Ser Ala Ala Lys Val Gln Cys Ser Glu Gln Trp Ile Pro Phe Gln Asn 945 950 955 960 Lys Cys Phe Leu Lys Ile Lys Pro Val Ser Leu Thr Phe Ser Gln Ala 965 970 975 Ser Asp Thr Cys His Ser Tyr Gly Gly Thr Leu Pro Ser Val Leu Ser 980 985 990 Gln Ile Glu Gln Asp Phe Ile Thr Ser Leu Leu Pro Asp Met Glu Ala 995 1000 1005 Thr Leu Trp Ile Gly Leu Arg Trp Thr Ala Tyr Glu Lys Ile Asn 1010 1015 1020 Lys Trp Thr Asp Asn Arg Glu Leu Thr Tyr Ser Asn Phe His Pro 1025 1030 1035 Leu Leu Val Ser Gly Arg Leu Arg Ile Pro Glu Asn Phe Phe Glu 1040 1045 1050 Glu Glu Ser Arg Tyr His Cys Ala Leu Ile Leu Asn Leu Gln Lys 1055 1060 1065 Ser Pro Phe Thr Gly Thr Trp Asn Phe Thr Ser Cys Ser Glu Arg 1070 1075 1080 His Phe Val Ser Leu Cys Gln Lys Tyr Ser Glu Val Lys Ser Arg 1085 1090 1095 Gln Thr Leu Gln Asn Ala Ser Glu Thr Val Lys Tyr Leu Asn Asn 1100 1105 1110 Leu Tyr Lys Ile Ile Pro Lys Thr Leu Thr Trp His Ser Ala Lys 1115 1120 1125 Arg Glu Cys Leu Lys Ser Asn Met Gln Leu Val Ser Ile Thr Asp 1130 1135 1140 Pro Tyr Gln Gln Ala Phe Leu Ser Val Gln Ala Leu Leu His Asn 1145 1150 1155 Ser Ser Leu Trp Ile Gly Leu Phe Ser Gln Asp Asp Glu Leu Asn 1160 1165 1170 Phe Gly Trp Ser Asp Gly Lys Arg Leu His Phe Ser Arg Trp Ala 1175 1180 1185 Glu Thr Asn Gly Gln Leu Glu Asp Cys Val Val Leu Asp Thr Asp 1190 1195 1200 Gly Phe Trp Lys Thr Val Asp Cys Asn Asp Asn Gln Pro Gly Ala 1205 1210 1215 Ile Cys Tyr Tyr Ser Gly Asn Glu Thr Glu Lys Glu Val Lys Pro 1220 1225 1230 Val Asp Ser Val Lys Cys Pro Ser Pro Val Leu Asn Thr Pro Trp 1235 1240 1245 Ile Pro Phe Gln Asn Cys Cys Tyr Asn Phe Ile Ile Thr Lys Asn 1250 1255 1260 Arg His Met Ala Thr Thr Gln Asp Glu Val His Thr Lys Cys Gln 1265 1270 1275 Lys Leu Asn Pro Lys Ser His Ile Leu Ser Ile Arg Asp Glu Lys 1280 1285 1290 Glu Asn Asn Phe Val Leu Glu Gln Leu Leu Tyr Phe Asn Tyr Met 1295 1300 1305 Ala Ser Trp Val Met Leu Gly Ile Thr Tyr Arg Asn Lys Ser Leu 1310 1315 1320 Met Trp Phe Asp Lys Thr Pro Leu Ser Tyr Thr His Trp Arg Ala 1325 1330 1335 Gly Arg Pro Thr Ile Lys Asn Glu Lys Phe Leu Ala Gly Leu Ser 1340 1345 1350 Thr Asp Gly Phe Trp Asp Ile Gln Thr Phe Lys Val Ile Glu Glu 1355 1360 1365 Ala Val Tyr Phe His Gln His Ser Ile Leu Ala Cys Lys Ile Glu 1370 1375 1380 Met Val Asp Tyr Lys Glu Glu Tyr Asn Thr Thr Leu Pro Gln Phe 1385 1390 1395 Met Pro Tyr Glu Asp Gly Ile Tyr Ser Val Ile Gln Lys Lys Val 1400 1405 1410 Thr Trp Tyr Glu Ala Leu Asn Met Cys Ser Gln Ser Gly Gly His 1415 1420 1425 Leu Ala Ser Val His Asn Gln Asn Gly Gln Leu Phe Leu Glu Asp 1430 1435 1440 Ile Val Lys Arg Asp Gly Phe Pro Leu Trp Val Gly Leu Ser Ser 1445 1450 1455 His Asp Gly Ser Glu Ser Ser Phe Glu Trp Ser Asp Gly Ser Thr 1460 1465 1470 Phe Asp Tyr Ile Pro Trp Lys Gly Gln Thr Ser Pro Gly Asn Cys 1475 1480 1485 Val Leu Leu Asp Pro Lys Gly Thr Trp Lys His Glu Lys Cys Asn 1490 1495 1500 Ser Val Lys Asp Gly Ala Ile Cys Tyr Lys Pro Thr Lys Ser Lys 1505 1510 1515 Lys Leu Ser Arg Leu Thr Tyr Ser Ser Arg Cys Pro Ala Ala Lys 1520 1525 1530 Glu Asn Gly Ser Arg Trp Ile Gln Tyr Lys Gly His Cys Tyr Lys 1535 1540 1545 Ser Asp Gln Ala Leu His Ser Phe Ser Glu Ala Lys Lys Leu Cys 1550 1555 1560 Ser Lys His Asp His Ser Ala Thr Ile Val Ser Ile Lys Asp Glu 1565 1570 1575 Asp Glu Asn Lys Phe Val Ser Arg Leu Met Arg Glu Asn Asn Asn 1580 1585 1590 Ile Thr Met Arg Val Trp Leu Gly Leu Ser Gln His Ser Val Asp 1595 1600 1605 Gln Ser Trp Ser Trp Leu Asp Gly Ser Glu Val Thr Phe Val Lys 1610 1615 1620 Trp Glu Asn Lys Ser Lys Ser Gly Val Gly Arg Cys Ser Met Leu 1625 1630 1635 Ile Ala Ser Asn Glu Thr Trp Lys Lys Val Glu Cys Glu His Gly 1640 1645 1650 Phe Gly Arg Val Val Cys Lys Val Pro Leu Gly Pro Asp Tyr Thr 1655 1660 1665 Ala Ile Ala Ile Ile Val Ala Thr Leu Ser Ile Leu Val Leu Met 1670 1675 1680 Gly Gly Leu Ile Trp Phe Leu Phe Gln Arg His Arg Leu His Leu 1685 1690 1695 Ala Gly Phe Ser Ser Val Arg Tyr Ala Gln Gly Val Asn Glu Asp 1700 1705 1710 Glu Ile Met Leu Pro Ser Phe His Asp 1715 1720 <210> 16 <211> 30 <212> PRT <213> Human <400> 16 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Tyr Ser 20 25 30 <210> 17 <211> 14 <212> PRT <213> Human <400> 17 Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly 1 5 10 <210> 18 <211> 32 <212> PRT <213> Human <400> 18 Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu Gln 1 5 10 15 Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile 20 25 30 <210> 19 <211> 11 <212> PRT <213> Human <400> 19 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 1 5 10 <210> 20 <211> 23 <212> PRT <213> Human <400> 20 Asp Val Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys 20 <210> 21 <211> 15 <212> PRT <213> Human <400> 21 Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Asn Leu Leu Ile Tyr 1 5 10 15 <210> 22 <211> 32 <212> PRT <213> Human <400> 22 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 1 5 10 15 Leu Thr Ile Ser Thr Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 20 25 30 <210> 23 <211> 11 <212> PRT <213> Human <400> 23 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 1 5 10 <210> 24 <211> 10 <212> PRT <213> Human <400> 24 Trp Glu Val Lys Asp Cys Arg Ser Phe Lys 1 5 10 <210> 25 <211> 12 <212> PRT <213> Human <400> 25 Pro Ala Ser Leu Ser Cys Tyr Lys Val Phe His Ala 1 5 10 <210> 26 <211> 20 <212> PRT <213> Human <400> 26 Pro Trp Arg Arg Gly Trp His Phe Tyr Asp Asp Arg Glu Phe Ile Tyr 1 5 10 15 Leu Arg Pro Phe 20 <210> 27 <211> 19 <212> PRT <213> Human <400> 27 Asp Asp His Phe Thr Tyr Ser Arg Tyr Pro Trp His Arg Phe Pro Val 1 5 10 15 Thr Phe Gly <210> 28 <211> 12 <212> PRT <213> Human <400> 28 Arg Glu Leu Thr Tyr Ser Asn Phe His Pro Leu Leu 1 5 10 <210> 29 <211> 17 <212> PRT <213> Human <400> 29 Phe Thr Ser Cys Ser Glu Arg His Phe Val Ser Leu Cys Gln Lys Tyr 1 5 10 15 Ser <210> 30 <211> 12 <212> PRT <213> Human <400> 30 Thr Val Lys Tyr Leu Asn Asn Leu Tyr Lys Ile Ile 1 5 10 <210> 31 <211> 11 <212> PRT <213> Human <400> 31 Glu Ala Val Tyr Phe His Gln His Ser Ile Leu 1 5 10 <210> 32 <211> 11 <212> PRT <213> Human <400> 32 Lys Lys Leu Ser Arg Leu Thr Tyr Ser Ser Cys 1 5 10 <210> 33 <211> 20 <212> PRT <213> Human <400> 33 Asn Gly Ser Arg Trp Ile Gln Tyr Lys Gly His Cys Tyr Lys Ser Asp 1 5 10 15 Gln Ala Leu His 20 <210> 34 <211> 25 <212> PRT <213> Human <400> 34 Ile Ser Glu Trp Pro Ile Asp Asp His Phe Thr Tyr Ser Arg Tyr Pro 1 5 10 15 Trp His Arg Phe Pro Val Thr Phe Gly 20 25 <210> 35 <211> 20 <212> PRT <213> Human <400> 35 Gln Thr Leu Gln Asn Ala Ser Glu Thr Val Lys Tyr Leu Asn Asn Leu 1 5 10 15 Tyr Lys Ile Ile 20 <210> 36 <211> 10 <212> PRT <213> Human <400> 36 Asp Asp His Phe Thr Tyr Ser Arg Tyr Pro 1 5 10 <210> 37 <211> 15 <212> PRT <213> Human <400> 37 Phe Thr Ser Cys Ser Glu Arg His Phe Val Ser Leu Cys Gln Lys 1 5 10 15 <210> 38 <211> 451 <212> PRT <213> Artificial Sequence <220> <223> Rituximab VH sequence <400> 38 Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 35 40 45 Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 50 55 60 Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 100 105 110 Ala Gly Thr Thr Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser 115 120 125 Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 130 135 140 Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 145 150 155 160 Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 165 170 175 Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 180 185 190 Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 195 200 205 Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Ala Glu Pro Lys Ser Cys 210 215 220 Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 225 230 235 240 Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 245 250 255 Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 260 265 270 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 275 280 285 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 290 295 300 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 305 310 315 320 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 325 330 335 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 340 345 350 Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 355 360 365 Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 370 375 380 Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 385 390 395 400 Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 405 410 415 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 420 425 430 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 435 440 445 Pro Gly Lys 450 <210> 39 <211> 213 <212> PRT <213> Artificial Sequence <220> <223> Rituximab VL sequence <400> 39 Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 1 5 10 15 Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile 20 25 30 His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 35 40 45 Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 50 55 60 Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 65 70 75 80 Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr 85 90 95 Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 100 105 110 Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 115 120 125 Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 130 135 140 Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 145 150 155 160 Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 165 170 175 Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 180 185 190 Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 195 200 205 Asn Arg Gly Glu Cys 210 <210> 40 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> Rituximab VH_CDR1 <400> 40 Ser Tyr Asn Met His 1 5 <210> 41 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Rituximab VH_CDR2 <400> 41 Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys 1 5 10 15 Gly <210> 42 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Rituximab VH_CDR3 <400> 42 Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val 1 5 10 <210> 43 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Rituximab VL_CDR1 <400> 43 Arg Ala Ser Ser Ser Val Ser Tyr Ile His 1 5 10 <210> 44 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> Rituximab VL_CDR2 <400> 44 Ala Thr Ser Asn Leu Ala Ser 1 5 <210> 45 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Rituximab VL_CDR3 <400> 45 Gln Gln Trp Thr Ser Asn Pro Pro Thr Phe 1 5 10 <210> 46 <211> 8 <212> PRT <213> Homo sapiens <400> 46 Gly Trp His Phe Tyr Asp Asp Arg 1 5 <210> 47 <211> 14 <212> PRT <213> Homo sapiens <400> 47 Ile Ser Glu Trp Pro Ile Asp Asp His Phe Thr Tyr Ser Arg 1 5 10 <210> 48 <211> 15 <212> PRT <213> Homo sapiens <400> 48 Phe Pro Val Thr Phe Gly Glu Glu Cys Leu Tyr Met Ser Ala Lys 1 5 10 15 <210> 49 <211> 15 <212> PRT <213> Homo sapiens <400> 49 Glu Leu Thr Tyr Ser Asn Phe His Pro Leu Leu Val Ser Gly Arg 1 5 10 15 <210> 50 <211> 8 <212> PRT <213> Homo sapiens <400> 50 His Phe Val Ser Leu Cys Gln Lys 1 5 <210> 51 <211> 11 <212> PRT <213> Homo sapiens <400> 51 Gln Thr Leu Gln Asn Ala Ser Glu Thr Val Lys 1 5 10 <210> 52 <211> 4 <212> PRT <213> Artificial Sequence <220> <223> Linker <400> 52 Gly Phe Leu Gly 1 <210> 53 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 53 Trp Glu Val Lys Asp Cys Arg Ser 1 5 <210> 54 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 54 Glu Val Lys Asp Cys Arg Ser Phe 1 5 <210> 55 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 55 Val Lys Asp Cys Arg Ser Phe Lys 1 5 <210> 56 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 56 Lys Asp Cys Arg Ser Phe Lys Ala 1 5 <210> 57 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 57 Asp Cys Arg Ser Phe Lys Ala Leu 1 5 <210> 58 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 58 Cys Arg Ser Phe Lys Ala Leu Ser 1 5 <210> 59 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 59 Arg Ser Phe Lys Ala Leu Ser Ile 1 5 <210> 60 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 60 Pro Ala Ser Leu Ser Cys Tyr Lys 1 5 <210> 61 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 61 Ala Ser Leu Ser Cys Tyr Lys Val 1 5 <210> 62 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 62 Ser Leu Ser Cys Tyr Lys Val Phe 1 5 <210> 63 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 63 Leu Ser Cys Tyr Lys Val Phe His 1 5 <210> 64 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 64 Ser Cys Tyr Lys Val Phe His Ala 1 5 <210> 65 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 65 Cys Tyr Lys Val Phe His Ala Glu 1 5 <210> 66 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 66 Tyr Lys Val Phe His Ala Glu Arg 1 5 <210> 67 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 67 Lys Val Phe His Ala Glu Arg Ile 1 5 <210> 68 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 68 Val Phe His Ala Glu Arg Ile Val 1 5 <210> 69 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 69 Phe His Ala Glu Arg Ile Val Arg 1 5 <210> 70 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 70 Asp Cys Ala Ala Val Lys Val Phe 1 5 <210> 71 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 71 Ala Ala Val Lys Val Phe His Arg 1 5 <210> 72 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 72 Val Lys Val Phe His Arg Pro Trp 1 5 <210> 73 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 73 Val Phe His Arg Pro Trp Arg Arg 1 5 <210> 74 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 74 His Arg Pro Trp Arg Arg Gly Trp 1 5 <210> 75 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 75 Pro Trp Arg Arg Gly Trp His Phe 1 5 <210> 76 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 76 Arg Arg Gly Trp His Phe Tyr Asp 1 5 <210> 77 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 77 Gly Trp His Phe Tyr Asp Asp Arg 1 5 <210> 78 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 78 His Phe Tyr Asp Asp Arg Glu Phe 1 5 <210> 79 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 79 Tyr Asp Asp Arg Glu Phe Ile Tyr 1 5 <210> 80 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 80 Asp Arg Glu Phe Ile Tyr Leu Arg 1 5 <210> 81 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 81 Glu Phe Ile Tyr Leu Arg Pro Phe 1 5 <210> 82 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 82 Pro Ile Asp Asp His Phe Thr Tyr 1 5 <210> 83 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 83 Ile Asp Asp His Phe Thr Tyr Ser 1 5 <210> 84 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 84 Asp Asp His Phe Thr Tyr Ser Arg 1 5 <210> 85 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 85 Asp His Phe Thr Tyr Ser Arg Tyr 1 5 <210> 86 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 86 His Phe Thr Tyr Ser Arg Tyr Pro 1 5 <210> 87 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 87 Phe Thr Tyr Ser Arg Tyr Pro Trp 1 5 <210> 88 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 88 Thr Tyr Ser Arg Tyr Pro Trp His 1 5 <210> 89 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 89 Tyr Ser Arg Tyr Pro Trp His Arg 1 5 <210> 90 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 90 Ser Arg Tyr Pro Trp His Arg Phe 1 5 <210> 91 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 91 Arg Tyr Pro Trp His Arg Phe Pro 1 5 <210> 92 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 92 Tyr Pro Trp His Arg Phe Pro Val 1 5 <210> 93 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 93 Pro Trp His Arg Phe Pro Val Thr 1 5 <210> 94 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 94 Trp His Arg Phe Pro Val Thr Phe 1 5 <210> 95 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 95 His Arg Phe Pro Val Thr Phe Gly 1 5 <210> 96 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 96 Arg Glu Leu Thr Tyr Ser Asn Phe 1 5 <210> 97 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 97 Glu Leu Thr Tyr Ser Asn Phe His 1 5 <210> 98 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 98 Leu Thr Tyr Ser Asn Phe His Pro 1 5 <210> 99 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 99 Thr Tyr Ser Asn Phe His Pro Leu 1 5 <210> 100 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 100 Tyr Ser Asn Phe His Pro Leu Leu 1 5 <210> 101 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 101 Ser Asn Phe His Pro Leu Leu Val 1 5 <210> 102 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 102 Asn Phe His Pro Leu Leu Val Ser 1 5 <210> 103 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 103 Phe His Pro Leu Leu Val Ser Gly 1 5 <210> 104 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 104 His Pro Leu Leu Val Ser Gly Arg 1 5 <210> 105 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 105 Pro Leu Leu Val Ser Gly Arg Leu 1 5 <210> 106 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 106 Leu Leu Val Ser Gly Arg Leu Arg 1 5 <210> 107 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 107 Leu Val Ser Gly Arg Leu Arg Ile 1 5 <210> 108 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 108 Val Ser Gly Arg Leu Arg Ile Pro 1 5 <210> 109 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 109 Phe Thr Ser Cys Ser Glu Arg His 1 5 <210> 110 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 110 Thr Ser Cys Ser Glu Arg His Phe 1 5 <210> 111 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 111 Ser Cys Ser Glu Arg His Phe Val 1 5 <210> 112 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 112 Cys Ser Glu Arg His Phe Val Ser 1 5 <210> 113 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 113 Ser Glu Arg His Phe Val Ser Leu 1 5 <210> 114 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 114 Glu Arg His Phe Val Ser Leu Cys 1 5 <210> 115 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 115 Arg His Phe Val Ser Leu Cys Gln 1 5 <210> 116 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 116 His Phe Val Ser Leu Cys Gln Lys 1 5 <210> 117 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 117 Phe Val Ser Leu Cys Gln Lys Tyr 1 5 <210> 118 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 118 Val Ser Leu Cys Gln Lys Tyr Ser 1 5 <210> 119 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 119 Ser Leu Cys Gln Lys Tyr Ser Glu 1 5 <210> 120 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 120 Leu Cys Gln Lys Tyr Ser Glu Val 1 5 <210> 121 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 121 Cys Gln Lys Tyr Ser Glu Val Lys 1 5 <210> 122 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 122 Gln Lys Tyr Ser Glu Val Lys Ser 1 5 <210> 123 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 123 Thr Val Lys Tyr Leu Asn Asn Leu 1 5 <210> 124 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 124 Val Lys Tyr Leu Asn Asn Leu Tyr 1 5 <210> 125 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 125 Lys Tyr Leu Asn Asn Leu Tyr Lys 1 5 <210> 126 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 126 Tyr Leu Asn Asn Leu Tyr Lys Ile 1 5 <210> 127 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 127 Leu Asn Asn Leu Tyr Lys Ile Ile 1 5 <210> 128 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 128 Asn Asn Leu Tyr Lys Ile Ile Pro 1 5 <210> 129 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 129 Asn Leu Tyr Lys Ile Ile Pro Lys 1 5 <210> 130 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 130 Leu Tyr Lys Ile Ile Pro Lys Thr 1 5 <210> 131 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 131 Tyr Lys Ile Ile Pro Lys Thr Leu 1 5 <210> 132 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 132 Lys Ile Ile Pro Lys Thr Leu Thr 1 5 <210> 133 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 133 Ile Ile Pro Lys Thr Leu Thr Trp 1 5 <210> 134 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 134 Ile Pro Lys Thr Leu Thr Trp His 1 5 <210> 135 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 135 Pro Lys Thr Leu Thr Trp His Ser 1 5 <210> 136 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 136 Lys Thr Leu Thr Trp His Ser Ala 1 5 <210> 137 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 137 Thr Leu Thr Trp His Ser Ala Lys 1 5 <210> 138 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 138 Glu Ala Val Tyr Phe His Gln His 1 5 <210> 139 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 139 Ala Val Tyr Phe His Gln His Ser 1 5 <210> 140 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 140 Val Tyr Phe His Gln His Ser Ile 1 5 <210> 141 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 141 Tyr Phe His Gln His Ser Ile Leu 1 5 <210> 142 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 142 Phe His Gln His Ser Ile Leu Ala 1 5 <210> 143 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 143 Lys Lys Leu Ser Arg Leu Thr Tyr 1 5 <210> 144 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 144 Lys Leu Ser Arg Leu Thr Tyr Ser 1 5 <210> 145 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 145 Leu Ser Arg Leu Thr Tyr Ser Ser 1 5 <210> 146 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 146 Ser Arg Leu Thr Tyr Ser Ser Arg 1 5 <210> 147 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 147 Arg Leu Thr Tyr Ser Ser Arg Cys 1 5 <210> 148 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 148 Asn Gly Ser Arg Trp Ile Gln Tyr 1 5 <210> 149 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 149 Gly Ser Arg Trp Ile Gln Tyr Lys 1 5 <210> 150 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 150 Ser Arg Trp Ile Gln Tyr Lys Gly 1 5 <210> 151 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 151 Arg Trp Ile Gln Tyr Lys Gly His 1 5 <210> 152 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 152 Trp Ile Gln Tyr Lys Gly His Cys 1 5 <210> 153 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 153 Ile Gln Tyr Lys Gly His Cys Tyr 1 5 <210> 154 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 154 Gln Tyr Lys Gly His Cys Tyr Lys 1 5 <210> 155 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 155 Tyr Lys Gly His Cys Tyr Lys Ser 1 5 <210> 156 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 156 Lys Gly His Cys Tyr Lys Ser Asp 1 5 <210> 157 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 157 Gly His Cys Tyr Lys Ser Asp Gln 1 5 <210> 158 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 158 His Cys Tyr Lys Ser Asp Gln Ala 1 5 <210> 159 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 159 Cys Tyr Lys Ser Asp Gln Ala Leu 1 5 <210> 160 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 160 Tyr Lys Ser Asp Gln Ala Leu His 1 5 <210> 161 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 161 Lys Ser Asp Gln Ala Leu His Ser 1 5 <210> 162 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 162 Ser Asp Gln Ala Leu His Ser Phe 1 5 <210> 163 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 163 Asp Gln Ala Leu His Ser Phe Ser 1 5 <210> 164 <211> 1722 <212> PRT <213> Homo sapiens <400> 164 Met Arg Thr Gly Trp Ala Thr Pro Arg Arg Pro Ala Gly Leu Leu Met 1 5 10 15 Leu Leu Phe Trp Phe Phe Asp Leu Ala Glu Pro Ser Gly Arg Ala Ala 20 25 30 Asn Asp Pro Phe Thr Ile Val His Gly Asn Thr Gly Lys Cys Ile Lys 35 40 45 Pro Val Tyr Gly Trp Ile Val Ala Asp Asp Cys Asp Glu Thr Glu Asp 50 55 60 Lys Leu Trp Lys Trp Val Ser Gln His Arg Leu Phe His Leu His Ser 65 70 75 80 Gln Lys Cys Leu Gly Leu Asp Ile Thr Lys Ser Val Asn Glu Leu Arg 85 90 95 Met Phe Ser Cys Asp Ser Ser Ala Met Leu Trp Trp Lys Cys Glu His 100 105 110 His Ser Leu Tyr Gly Ala Ala Arg Tyr Arg Leu Ala Leu Lys Asp Gly 115 120 125 His Gly Thr Ala Ile Ser Asn Ala Ser Asp Val Trp Lys Lys Gly Gly 130 135 140 Ser Glu Glu Ser Leu Cys Asp Gln Pro Tyr His Glu Ile Tyr Thr Arg 145 150 155 160 Asp Gly Asn Ser Tyr Gly Arg Pro Cys Glu Phe Pro Phe Leu Ile Asp 165 170 175 Gly Thr Trp His His Asp Cys Ile Leu Asp Glu Asp His Ser Gly Pro 180 185 190 Trp Cys Ala Thr Thr Leu Asn Tyr Glu Tyr Asp Arg Lys Trp Gly Ile 195 200 205 Cys Leu Lys Pro Glu Asn Gly Cys Glu Asp Asn Trp Glu Lys Asn Glu 210 215 220 Gln Phe Gly Ser Cys Tyr Gln Phe Asn Thr Gln Thr Ala Leu Ser Trp 225 230 235 240 Lys Glu Ala Tyr Val Ser Cys Gln Asn Gln Gly Ala Asp Leu Leu Ser 245 250 255 Ile Asn Ser Ala Ala Glu Leu Thr Tyr Leu Lys Glu Lys Glu Gly Ile 260 265 270 Ala Lys Ile Phe Trp Ile Gly Leu Asn Gln Leu Tyr Ser Ala Arg Gly 275 280 285 Trp Glu Trp Ser Asp His Lys Pro Leu Asn Phe Leu Asn Trp Asp Pro 290 295 300 Asp Arg Pro Ser Ala Pro Thr Ile Gly Gly Ser Ser Cys Ala Arg Met 305 310 315 320 Asp Ala Glu Ser Gly Leu Trp Gln Ser Phe Ser Cys Glu Ala Gln Leu 325 330 335 Pro Tyr Val Cys Arg Lys Pro Leu Asn Asn Thr Val Glu Leu Thr Asp 340 345 350 Val Trp Thr Tyr Ser Asp Thr Arg Cys Asp Ala Gly Trp Leu Pro Asn 355 360 365 Asn Gly Phe Cys Tyr Leu Leu Val Asn Glu Ser Asn Ser Trp Asp Lys 370 375 380 Ala His Ala Lys Cys Lys Ala Phe Ser Ser Asp Leu Ile Ser Ile His 385 390 395 400 Ser Leu Ala Asp Val Glu Val Val Val Thr Lys Leu His Asn Glu Asp 405 410 415 Ile Lys Glu Glu Val Trp Ile Gly Leu Lys Asn Ile Asn Ile Pro Thr 420 425 430 Leu Phe Gln Trp Ser Asp Gly Thr Glu Val Thr Leu Thr Tyr Trp Asp 435 440 445 Glu Asn Glu Pro Asn Val Pro Tyr Asn Lys Thr Pro Asn Cys Val Ser 450 455 460 Tyr Leu Gly Glu Leu Gly Gln Trp Lys Val Gln Ser Cys Glu Glu Lys 465 470 475 480 Leu Lys Tyr Val Cys Lys Arg Lys Gly Glu Lys Leu Asn Asp Ala Ser 485 490 495 Ser Asp Lys Met Cys Pro Pro Asp Glu Gly Trp Lys Arg His Gly Glu 500 505 510 Thr Cys Tyr Lys Ile Tyr Glu Asp Glu Val Pro Phe Gly Thr Asn Cys 515 520 525 Asn Leu Thr Ile Thr Ser Arg Phe Glu Gln Glu Tyr Leu Asn Asp Leu 530 535 540 Met Lys Lys Tyr Asp Lys Ser Leu Arg Lys Tyr Phe Trp Thr Gly Leu 545 550 555 560 Arg Asp Val Asp Ser Cys Gly Glu Tyr Asn Trp Ala Thr Val Gly Gly 565 570 575 Arg Arg Arg Ala Val Thr Phe Ser Asn Trp Asn Phe Leu Glu Pro Ala 580 585 590 Ser Pro Gly Gly Cys Val Ala Met Ser Thr Gly Lys Ser Val Gly Lys 595 600 605 Trp Glu Val Lys Asp Cys Arg Ser Phe Lys Ala Leu Ser Ile Cys Lys 610 615 620 Lys Met Ser Gly Pro Leu Gly Pro Glu Glu Ala Ser Pro Lys Pro Asp 625 630 635 640 Asp Pro Cys Pro Glu Gly Trp Gln Ser Phe Pro Ala Ser Leu Ser Cys 645 650 655 Tyr Lys Val Phe His Ala Glu Arg Ile Val Arg Lys Arg Asn Trp Glu 660 665 670 Glu Ala Glu Arg Phe Cys Gln Ala Leu Gly Ala His Leu Ser Ser Phe 675 680 685 Ser His Val Asp Glu Ile Lys Glu Phe Leu His Phe Leu Thr Asp Gln 690 695 700 Phe Ser Gly Gln His Trp Leu Trp Ile Gly Leu Asn Lys Arg Ser Pro 705 710 715 720 Asp Leu Gln Gly Ser Trp Gln Trp Ser Asp Arg Thr Pro Val Ser Thr 725 730 735 Ile Ile Met Pro Asn Glu Phe Gln Gln Asp Tyr Asp Ile Arg Asp Cys 740 745 750 Ala Ala Val Lys Val Phe His Arg Pro Trp Arg Arg Gly Trp His Phe 755 760 765 Tyr Asp Asp Arg Glu Phe Ile Tyr Leu Arg Pro Phe Ala Cys Asp Thr 770 775 780 Lys Leu Glu Trp Val Cys Gln Ile Pro Lys Gly Arg Thr Pro Lys Thr 785 790 795 800 Pro Asp Trp Tyr Asn Pro Asp Arg Ala Gly Ile His Gly Pro Pro Leu 805 810 815 Ile Ile Glu Gly Ser Glu Tyr Trp Phe Val Ala Asp Leu His Leu Asn 820 825 830 Tyr Glu Glu Ala Val Leu Tyr Cys Ala Ser Asn His Ser Phe Leu Ala 835 840 845 Thr Ile Thr Ser Phe Val Gly Leu Lys Ala Ile Lys Asn Lys Ile Ala 850 855 860 Asn Ile Ser Gly Asp Gly Gln Lys Trp Trp Ile Arg Ile Ser Glu Trp 865 870 875 880 Pro Ile Asp Asp His Phe Thr Tyr Ser Arg Tyr Pro Trp His Arg Phe 885 890 895 Pro Val Thr Phe Gly Glu Glu Cys Leu Tyr Met Ser Ala Lys Thr Trp 900 905 910 Leu Ile Asp Leu Gly Lys Pro Thr Asp Cys Ser Thr Lys Leu Pro Phe 915 920 925 Ile Cys Glu Lys Tyr Asn Val Ser Ser Leu Glu Lys Tyr Ser Pro Asp 930 935 940 Ser Ala Ala Lys Val Gln Cys Ser Glu Gln Trp Ile Pro Phe Gln Asn 945 950 955 960 Lys Cys Phe Leu Lys Ile Lys Pro Val Ser Leu Thr Phe Ser Gln Ala 965 970 975 Ser Asp Thr Cys His Ser Tyr Gly Gly Thr Leu Pro Ser Val Leu Ser 980 985 990 Gln Ile Glu Gln Asp Phe Ile Thr Ser Leu Leu Pro Asp Met Glu Ala 995 1000 1005 Thr Leu Trp Ile Gly Leu Arg Trp Thr Ala Tyr Glu Lys Ile Asn 1010 1015 1020 Lys Trp Thr Asp Asn Arg Glu Leu Thr Tyr Ser Asn Phe His Pro 1025 1030 1035 Leu Leu Val Ser Gly Arg Leu Arg Ile Pro Glu Asn Phe Phe Glu 1040 1045 1050 Glu Glu Ser Arg Tyr His Cys Ala Leu Ile Leu Asn Leu Gln Lys 1055 1060 1065 Ser Pro Phe Thr Gly Thr Trp Asn Phe Thr Ser Cys Ser Glu Arg 1070 1075 1080 His Phe Val Ser Leu Cys Gln Lys Tyr Ser Glu Val Lys Ser Arg 1085 1090 1095 Gln Thr Leu Gln Asn Ala Ser Glu Thr Val Lys Tyr Leu Asn Asn 1100 1105 1110 Leu Tyr Lys Ile Ile Pro Lys Thr Leu Thr Trp His Ser Ala Lys 1115 1120 1125 Arg Glu Cys Leu Lys Ser Asn Met Gln Leu Val Ser Ile Thr Asp 1130 1135 1140 Pro Tyr Gln Gln Ala Phe Leu Ser Val Gln Ala Leu Leu His Asn 1145 1150 1155 Ser Ser Leu Trp Ile Gly Leu Phe Ser Gln Asp Asp Glu Leu Asn 1160 1165 1170 Phe Gly Trp Ser Asp Gly Lys Arg Leu His Phe Ser Arg Trp Ala 1175 1180 1185 Glu Thr Asn Gly Gln Leu Glu Asp Cys Val Val Leu Asp Thr Asp 1190 1195 1200 Gly Phe Trp Lys Thr Val Asp Cys Asn Asp Asn Gln Pro Gly Ala 1205 1210 1215 Ile Cys Tyr Tyr Ser Gly Asn Glu Thr Glu Lys Glu Val Lys Pro 1220 1225 1230 Val Asp Ser Val Lys Cys Pro Ser Pro Val Leu Asn Thr Pro Trp 1235 1240 1245 Ile Pro Phe Gln Asn Cys Cys Tyr Asn Phe Ile Ile Thr Lys Asn 1250 1255 1260 Arg His Met Ala Thr Thr Gln Asp Glu Val His Thr Lys Cys Gln 1265 1270 1275 Lys Leu Asn Pro Lys Ser His Ile Leu Ser Ile Arg Asp Glu Lys 1280 1285 1290 Glu Asn Asn Phe Val Leu Glu Gln Leu Leu Tyr Phe Asn Tyr Met 1295 1300 1305 Ala Ser Trp Val Met Leu Gly Ile Thr Tyr Arg Asn Lys Ser Leu 1310 1315 1320 Met Trp Phe Asp Lys Thr Pro Leu Ser Tyr Thr His Trp Arg Ala 1325 1330 1335 Gly Arg Pro Thr Ile Lys Asn Glu Lys Phe Leu Ala Gly Leu Ser 1340 1345 1350 Thr Asp Gly Phe Trp Asp Ile Gln Thr Phe Lys Val Ile Glu Glu 1355 1360 1365 Ala Val Tyr Phe His Gln His Ser Ile Leu Ala Cys Lys Ile Glu 1370 1375 1380 Met Val Asp Tyr Lys Glu Glu Tyr Asn Thr Thr Leu Pro Gln Phe 1385 1390 1395 Met Pro Tyr Glu Asp Gly Ile Tyr Ser Val Ile Gln Lys Lys Val 1400 1405 1410 Thr Trp Tyr Glu Ala Leu Asn Met Cys Ser Gln Ser Gly Gly His 1415 1420 1425 Leu Ala Ser Val His Asn Gln Asn Gly Gln Leu Phe Leu Glu Asp 1430 1435 1440 Ile Val Lys Arg Asp Gly Phe Pro Leu Trp Val Gly Leu Ser Ser 1445 1450 1455 His Asp Gly Ser Glu Ser Ser Phe Glu Trp Ser Asp Gly Ser Thr 1460 1465 1470 Phe Asp Tyr Ile Pro Trp Lys Gly Gln Thr Ser Pro Gly Asn Cys 1475 1480 1485 Val Leu Leu Asp Pro Lys Gly Thr Trp Lys His Glu Lys Cys Asn 1490 1495 1500 Ser Val Lys Asp Gly Ala Ile Cys Tyr Lys Pro Thr Lys Ser Lys 1505 1510 1515 Lys Leu Ser Arg Leu Thr Tyr Ser Ser Arg Cys Pro Ala Ala Lys 1520 1525 1530 Glu Asn Gly Ser Arg Trp Ile Gln Tyr Lys Gly His Cys Tyr Lys 1535 1540 1545 Ser Asp Gln Ala Leu His Ser Phe Ser Glu Ala Lys Lys Leu Cys 1550 1555 1560 Ser Lys His Asp His Ser Ala Thr Ile Val Ser Ile Lys Asp Glu 1565 1570 1575 Asp Glu Asn Lys Phe Val Ser Arg Leu Met Arg Glu Asn Asn Asn 1580 1585 1590 Ile Thr Met Arg Val Trp Leu Gly Leu Ser Gln His Ser Val Asp 1595 1600 1605 Gln Ser Trp Ser Trp Leu Asp Gly Ser Glu Val Thr Phe Val Lys 1610 1615 1620 Trp Glu Asn Lys Ser Lys Ser Gly Val Gly Arg Cys Ser Met Leu 1625 1630 1635 Ile Ala Ser Asn Glu Thr Trp Lys Lys Val Glu Cys Glu His Gly 1640 1645 1650 Phe Gly Arg Val Val Cys Lys Val Pro Leu Gly Pro Asp Tyr Thr 1655 1660 1665 Ala Ile Ala Ile Ile Val Ala Thr Leu Ser Ile Leu Val Leu Met 1670 1675 1680 Gly Gly Leu Ile Trp Phe Leu Phe Gln Arg His Arg Leu His Leu 1685 1690 1695 Ala Gly Phe Ser Ser Val Arg Tyr Ala Gln Gly Val Asn Glu Asp 1700 1705 1710 Glu Ile Met Leu Pro Ser Phe His Asp 1715 1720 <210> 165 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 165 Cys Ile Lys Pro Val Tyr Gly Trp Ile Val Ala Asp Asp Cys Asp Glu 1 5 10 15 Thr Glu Asp Lys Leu Trp Lys 20 <210> 166 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 166 Cys Glu His His Ser Leu Tyr Gly Ala Ala Arg 1 5 10 <210> 167 <211> 34 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 167 Asp Gly His Gly Thr Ala Ile Ser Asn Ala Ser Asp Val Trp Lys Lys 1 5 10 15 Gly Gly Ser Glu Glu Ser Leu Cys Asp Gln Pro Tyr His Glu Ile Tyr 20 25 30 Thr Arg <210> 168 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 168 Lys Gly Gly Ser Glu Glu Ser Leu Cys Asp Gln Pro Tyr His Glu Ile 1 5 10 15 Tyr Thr Arg <210> 169 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 169 Gly Gly Ser Glu Glu Ser Leu Cys Asp Gln Pro Tyr His Glu Ile Tyr 1 5 10 15 Thr Arg <210> 170 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 170 Asp Gly His Gly Thr Ala Ile Ser Asn Ala Ser Asp Val Trp Lys 1 5 10 15 <210> 171 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 171 Trp Gly Ile Cys Leu Lys Pro Glu Asn Gly Cys Glu Asp Asn Trp Glu 1 5 10 15 Lys <210> 172 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 172 Ile Phe Trp Ile Gly Leu Asn Gln Leu Tyr Ser Ala Arg 1 5 10 <210> 173 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 173 Leu His Asn Glu Asp Ile Lys Glu Glu Val Trp Ile Gly Leu Lys 1 5 10 15 <210> 174 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 174 Thr Pro Asn Cys Val Ser Tyr Leu Gly Glu Leu Gly Gln Trp Lys 1 5 10 15 <210> 175 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 175 Tyr Phe Trp Thr Gly Leu Arg Asp Val Asp Ser Cys Gly Glu Tyr Asn 1 5 10 15 Trp Ala Thr Val Gly Gly Arg 20 <210> 176 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 176 Ser Val Gly Lys Trp Glu Val Lys Asp Cys Arg 1 5 10 <210> 177 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 177 Trp Glu Val Lys Asp Cys Arg Ser Phe Lys 1 5 10 <210> 178 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 178 Ala Leu Ser Ile Cys Lys Lys 1 5 <210> 179 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 179 Pro Ala Ser Leu Ser Cys Tyr Lys Val Phe His Ala 1 5 10 <210> 180 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 180 Arg Asn Trp Glu Glu Ala Glu Arg 1 5 <210> 181 <211> 33 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 181 Arg Ser Pro Asp Leu Gln Gly Ser Trp Gln Trp Ser Asp Arg Thr Pro 1 5 10 15 Val Ser Thr Ile Ile Met Pro Asn Glu Phe Gln Gln Asp Tyr Asp Ile 20 25 30 Arg <210> 182 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 182 Thr Pro Val Ser Thr Ile Ile Met Pro Asn Glu Phe Gln Gln Asp Tyr 1 5 10 15 Asp Ile Arg <210> 183 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 183 Pro Trp Arg Arg Gly Trp His Phe Tyr Asp Asp Arg Glu Phe Ile Tyr 1 5 10 15 Leu Arg Pro Phe 20 <210> 184 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 184 Gly Trp His Phe Tyr Asp Asp Arg 1 5 <210> 185 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 185 Ile Ser Glu Trp Pro Ile Asp Asp His Phe Thr Tyr Ser Arg 1 5 10 <210> 186 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 186 Asp Asp His Phe Thr Tyr Ser Arg Tyr Pro Trp His Arg Phe Pro Val 1 5 10 15 Thr Phe Gly <210> 187 <211> 30 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 187 Phe Pro Val Thr Phe Gly Glu Glu Cys Leu Tyr Met Ser Ala Lys Thr 1 5 10 15 Trp Leu Ile Asp Leu Gly Lys Pro Thr Asp Cys Ser Thr Lys 20 25 30 <210> 188 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 188 Thr Trp Leu Ile Asp Leu Gly Lys Pro Thr Asp Cys Ser Thr Lys 1 5 10 15 <210> 189 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 189 Tyr Asn Val Ser Ser Leu Glu Lys 1 5 <210> 190 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 190 Val Gln Cys Ser Glu Gln Trp Ile Pro Phe Gln Asn 1 5 10 <210> 191 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 191 Arg Glu Leu Thr Tyr Ser Asn Phe His Pro Leu Leu 1 5 10 <210> 192 <211> 39 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 192 Glu Leu Thr Tyr Ser Asn Phe His Pro Leu Leu Val Ser Gly Arg Leu 1 5 10 15 Arg Ile Pro Glu Asn Phe Phe Glu Glu Glu Ser Arg Tyr His Cys Ala 20 25 30 Leu Ile Leu Asn Leu Gln Lys 35 <210> 193 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 193 Tyr His Cys Ala Leu Ile Leu Asn Leu Gln Lys 1 5 10 <210> 194 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 194 Phe Thr Ser Cys Ser Glu Arg His Phe Val Ser Leu Cys Gln Lys Tyr 1 5 10 15 Ser <210> 195 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 195 His Phe Val Ser Leu Cys Gln Lys 1 5 <210> 196 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 196 Gln Thr Leu Gln Asn Ala Ser Glu Thr Val Lys 1 5 10 <210> 197 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 197 Thr Val Lys Tyr Leu Asn Asn Leu Tyr Lys Ile Ile 1 5 10 <210> 198 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 198 Thr Leu Thr Trp His Ser Ala Lys 1 5 <210> 199 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 199 Asn Arg His Met Ala Thr Thr Gln Asp Glu Val His Thr Lys 1 5 10 <210> 200 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 200 Ser His Ile Leu Ser Ile Arg 1 5 <210> 201 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 201 Ser Leu Met Trp Phe Asp Lys Thr Pro Leu Ser Tyr Thr His Trp Arg 1 5 10 15 <210> 202 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 202 Ser Leu Met Trp Phe Asp Lys 1 5 <210> 203 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 203 Glu Ala Val Tyr Phe His Gln His Ser Ile Leu 1 5 10 <210> 204 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 204 Lys Lys Leu Ser Arg Leu Thr Tyr Ser Ser 1 5 10 <210> 205 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 205 Asn Gly Ser Arg Trp Ile Gln Tyr Lys Gly His Cys Tyr Lys Ser Asp 1 5 10 15 Gln Ala Leu His 20 <210> 206 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 206 His Asp His Ser Ala Thr Ile Val Ser Ile Lys Asp Glu Asp Glu Asn 1 5 10 15 Lys Phe Val Ser Arg 20 <210> 207 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Peptide <400> 207 Val Glu Cys Glu His Gly Phe Gly Arg 1 5