LISTADO DE SECUENCIAS <110> I-MAB <120> ANTICUERPOS ANTI-CD73 Y USOS DE LOS MISMOS <130> 54LW-250265-WO2 <140> PCT/CN2018/073746 <141> 2018-01-23 <150> PCT/CN2017/072445 <151> 2017-01-24 <160> 61 <170> PatentIn version 3.5 <210> 1 <211> 6 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 1 Ser Gly Tyr Tyr Trp Asn 1 5 <210> 2 <211> 16 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 2 Tyr Ile Asn Tyr Gly Gly Ser Asn Gly Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 3 <211> 11 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 3 Asp Tyr Asp Ala Tyr Tyr Glu Ala Leu Asp Asp 1 5 10 <210> 4 <211> 10 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 4 Arg Ala Ser Ser Arg Val Asn Tyr Met His 1 5 10 <210> 5 <211> 7 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 5 Ala Thr Ser Asn Leu Ala Ser 1 5 <210> 6 <211> 9 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 6 Gln Gln Trp Ser Ser Asn Pro Pro Thr 1 5 <210> 7 <211> 120 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 7 Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Thr Ser Gly 20 25 30 Tyr Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Lys Leu Glu Trp 35 40 45 Met Gly Tyr Ile Asn Tyr Gly Gly Ser Asn Gly Tyr Asn Pro Ser Leu 50 55 60 Lys Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 65 70 75 80 Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Tyr Asp Ala Tyr Tyr Glu Ala Leu Asp Asp Trp Gly Gln 100 105 110 Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 8 <211> 106 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 8 Glu Ile Val Leu Ser Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Ser Arg Val Asn Tyr Met 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Arg Pro Trp Ile Ser 35 40 45 Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 50 55 60 Gly Ser Gly Thr Ser Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 65 70 75 80 Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr 85 90 95 Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 9 <211> 120 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 9 Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 20 25 30 Tyr Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Gly Tyr Ile Asn Tyr Gly Gly Ser Asn Gly Tyr Asn Pro Ser Leu 50 55 60 Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 65 70 75 80 Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Tyr Asp Ala Tyr Tyr Glu Ala Leu Asp Asp Trp Gly Gln 100 105 110 Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 10 <211> 120 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 10 Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 1 5 10 15 Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 20 25 30 Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 35 40 45 Met Gly Tyr Ile Asn Tyr Gly Gly Ser Asn Gly Tyr Asn Pro Ser Leu 50 55 60 Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 65 70 75 80 Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 85 90 95 Ala Arg Asp Tyr Asp Ala Tyr Tyr Glu Ala Leu Asp Asp Trp Gly Gln 100 105 110 Gly Thr Ser Val Thr Val Ser Ser 115 120 <210> 11 <211> 120 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 11 Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 20 25 30 Tyr Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Gly Tyr Ile Asn Tyr Gly Gly Ser Asn Gly Tyr Asn Pro Ser Leu 50 55 60 Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 65 70 75 80 Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Tyr Asp Ala Tyr Tyr Glu Ala Leu Asp Asp Trp Gly Gln 100 105 110 Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 12 <211> 120 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 12 Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 20 25 30 Tyr Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Gly Tyr Ile Asn Tyr Gly Gly Ser Asn Gly Tyr Asn Pro Ser Leu 50 55 60 Lys Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 65 70 75 80 Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Tyr Asp Ala Tyr Tyr Glu Ala Leu Asp Asp Trp Gly Gln 100 105 110 Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 13 <211> 120 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 13 Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 20 25 30 Tyr Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 35 40 45 Met Gly Tyr Ile Asn Tyr Gly Gly Ser Asn Gly Tyr Asn Pro Ser Leu 50 55 60 Lys Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 65 70 75 80 Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Tyr Asp Ala Tyr Tyr Glu Ala Leu Asp Asp Trp Gly Gln 100 105 110 Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 14 <211> 109 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 14 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 20 25 30 Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Gly Ser Ile Tyr His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu 50 55 60 Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 65 70 75 80 Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 100 105 <210> 15 <211> 106 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 15 Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 1 5 10 15 Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Arg Val Asn Tyr Met 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Ser 35 40 45 Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 50 55 60 Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Thr Glu 65 70 75 80 Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr 85 90 95 Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 16 <211> 106 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 16 Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 1 5 10 15 Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Ser Arg Val Asn Tyr Met 20 25 30 His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile Lys 35 40 45 Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 50 55 60 Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala Glu 65 70 75 80 Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr 85 90 95 Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 17 <211> 106 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 17 Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 1 5 10 15 Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Ser Arg Val Asn Tyr Met 20 25 30 His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile Lys 35 40 45 Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 50 55 60 Gly Ser Gly Thr Ser Tyr Thr Leu Thr Ile Asn Ser Leu Glu Ala Glu 65 70 75 80 Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr 85 90 95 Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 18 <211> 106 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 18 Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 1 5 10 15 Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Ser Arg Val Asn Tyr Met 20 25 30 His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile Ser 35 40 45 Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 50 55 60 Gly Ser Gly Thr Ser Tyr Thr Leu Thr Ile Asn Ser Leu Glu Ala Glu 65 70 75 80 Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr 85 90 95 Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 19 <211> 106 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 19 Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 1 5 10 15 Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Ser Arg Val Asn Tyr Met 20 25 30 His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Pro Trp Ile Ser 35 40 45 Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 50 55 60 Gly Ser Gly Thr Ser Tyr Thr Leu Thr Ile Asn Ser Leu Glu Ala Glu 65 70 75 80 Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr 85 90 95 Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 20 <211> 106 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 20 Glu Ile Val Leu Ser Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 1 5 10 15 Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Ser Arg Val Asn Tyr Met 20 25 30 His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Pro Trp Ile Ser 35 40 45 Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 50 55 60 Gly Ser Gly Thr Ser Tyr Thr Leu Thr Ile Asn Ser Leu Glu Ala Glu 65 70 75 80 Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr 85 90 95 Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 21 <211> 98 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 21 Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 1 5 10 15 Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Ser Ser 20 25 30 Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 35 40 45 Lys Tyr Ala Ser Gln Ser Phe Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala 65 70 75 80 Glu Asp Ala Ala Thr Tyr Tyr Cys Phe Gly Gly Gly Thr Lys Val Glu 85 90 95 Ile Lys <210> 22 <211> 106 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 22 Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Ser Arg Val Asn Tyr Met 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 35 40 45 Ala Thr Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 50 55 60 Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 65 70 75 80 Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr 85 90 95 Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 23 <211> 106 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 23 Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Ser Arg Val Asn Tyr Met 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 35 40 45 Ala Thr Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 50 55 60 Gly Ser Gly Thr Ser Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 65 70 75 80 Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr 85 90 95 Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 24 <211> 106 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 24 Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Ser Arg Val Asn Tyr Met 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Ser 35 40 45 Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 50 55 60 Gly Ser Gly Thr Ser Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 65 70 75 80 Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr 85 90 95 Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 25 <211> 98 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 25 Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gly Gly Gly Thr Lys Val Glu 85 90 95 Ile Lys <210> 26 <211> 6 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 26 Thr Gly Tyr Tyr Trp Asn 1 5 <210> 27 <211> 6 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 27 Cys Gly Tyr Tyr Trp Asn 1 5 <210> 28 <211> 6 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 28 Ser Ala Tyr Tyr Trp Asn 1 5 <210> 29 <211> 6 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 29 Ser Pro Tyr Tyr Trp Asn 1 5 <210> 30 <211> 16 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 30 Tyr Ile Asn Tyr Gly Ala Ser Asn Gly Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 31 <211> 16 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 31 Tyr Ile Asn Tyr Gly Pro Ser Asn Gly Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 32 <211> 16 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 32 Tyr Ile Asn Tyr Gly Gly Thr Asn Gly Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 33 <211> 16 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 33 Tyr Ile Asn Tyr Gly Gly Cys Asn Gly Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 34 <211> 16 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 34 Tyr Ile Asn Tyr Gly Gly Ser Asp Gly Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 35 <211> 16 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 35 Tyr Ile Asn Tyr Gly Gly Ser Glu Gly Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 36 <211> 16 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 36 Tyr Ile Asn Tyr Gly Gly Ser Gln Gly Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 37 <211> 11 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 37 Asp Tyr Asp Ala Tyr Tyr Asp Ala Leu Asp Asp 1 5 10 <210> 38 <211> 11 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 38 Asp Tyr Asp Ala Tyr Tyr Gln Ala Leu Asp Asp 1 5 10 <210> 39 <211> 11 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 39 Asp Tyr Asp Ala Tyr Tyr Asn Ala Leu Asp Asp 1 5 10 <210> 40 <211> 11 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 40 Asp Tyr Asp Ala Tyr Tyr Glu Gly Leu Asp Asp 1 5 10 <210> 41 <211> 11 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 41 Asp Tyr Asp Ala Tyr Tyr Glu Cys Leu Asp Asp 1 5 10 <210> 42 <211> 10 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 42 Arg Ala Thr Ser Arg Val Asn Tyr Met His 1 5 10 <210> 43 <211> 10 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 43 Arg Ala Cys Ser Arg Val Asn Tyr Met His 1 5 10 <210> 44 <211> 10 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 44 Arg Ala Ser Thr Arg Val Asn Tyr Met His 1 5 10 <210> 45 <211> 10 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 45 Arg Ala Ser Cys Arg Val Asn Tyr Met His 1 5 10 <210> 46 <211> 9 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 46 Asn Gln Trp Ser Ser Asn Pro Pro Thr 1 5 <210> 47 <211> 9 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 47 Asp Gln Trp Ser Ser Asn Pro Pro Thr 1 5 <210> 48 <211> 9 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 48 Glu Gln Trp Ser Ser Asn Pro Pro Thr 1 5 <210> 49 <211> 9 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 49 Gln Asn Trp Ser Ser Asn Pro Pro Thr 1 5 <210> 50 <211> 9 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 50 Gln Asp Trp Ser Ser Asn Pro Pro Thr 1 5 <210> 51 <211> 9 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 51 Gln Glu Trp Ser Ser Asn Pro Pro Thr 1 5 <210> 52 <211> 9 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 52 Gln Gln Tyr Ser Ser Asn Pro Pro Thr 1 5 <210> 53 <211> 9 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 53 Gln Gln Trp Thr Ser Asn Pro Pro Thr 1 5 <210> 54 <211> 9 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 54 Gln Gln Trp Cys Ser Asn Pro Pro Thr 1 5 <210> 55 <211> 9 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 55 Gln Gln Trp Ser Thr Asn Pro Pro Thr 1 5 <210> 56 <211> 9 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 56 Gln Gln Trp Ser Cys Asn Pro Pro Thr 1 5 <210> 57 <211> 360 <212> ADN <213> Secuencia Artificial <220> <223> Sintética <400> 57 gatgtacagc ttcaggagtc aggacctggc ctcgtgaaac cttctcagtc tctgtctctc 60 acctgctctg tcactggcta ctccatcacc agtggttatt actggaactg gatccggcag 120 tttccaggaa acaaactgga atggatgggc tacataaact acggcggtag caatggctac 180 aacccatctc tcaaaagtcg gatctccatc actcgggaca catctaagaa ccagtttttc 240 ctgaagctga attctgtgac tactgaggac acagctacat attactgtgc aagagactat 300 gatggttact acgaagctct ggacgactgg ggtcaaggaa cctcagtcac cgtctcctca 360 <210> 58 <211> 318 <212> ADN <213> Secuencia Artificial <220> <223> Sintética <400> 58 caaattgttc tctcccagtc tccagcaatc ctgtctgcat ctccagggga gaaggtcaca 60 atgacttgca gggccagctc acgtgtaaat tacatgcact ggtaccagca gaagccagga 120 tcctccccca aaccctggat ttctgccaca tccaacctgg cttctggagt ccctgctcgc 180 ttcagtggca gtgggtctgg gacctcttac tctctcacaa ttagcagagt agagactgaa 240 gatgctgcca cttattactg ccagcagtgg agtagtaacc cacccacgtt cggagggggg 300 accaagctgg aaataaaa 318 <210> 59 <211> 360 <212> ADN <213> Secuencia Artificial <220> <223> Sintética <400> 59 gaggtacagc ttcaggagtc aggacctggc ctcgtgaaac cttctgagac tctgtctctc 60 acctgcgctg tctctggcta ctccatcacc agtggttatt actggaactg gatccggcag 120 cctccaggaa agaagctgga atggatgggc tacatcaact acggcggtag caatggctac 180 aacccatctc tcaaaagtcg gatcaccatc tctagggaca catctaagaa ccagttttcc 240 ctgaagctga gttctgtgac tgctgccgac acagctgtgt attactgtgc aagagactat 300 gatgcttact acgaagctct ggacgactgg ggtcaaggaa ccacagtcac cgtctcctca 360 <210> 60 <211> 318 <212> ADN <213> Secuencia Artificial <220> <223> Sintética <400> 60 gaaattgttc tctcccagtc tccagcaacc ctgtctctgt ctccagggga gagggccaca 60 ctgtcttgca gggccagctc acgtgtaaat tacatgcact ggtaccagca gaagccagga 120 cagtccccca gaccctggat ttctgccaca tccaacctgg cttctggagt ccctgctcgc 180 ttcagtggca gtgggtctgg gacctcttac actctcacaa ttagcagcct ggagccagaa 240 gatttcgccg tgtattactg ccagcagtgg agtagtaacc cacccacgtt cggagggggg 300 accaaggtgg aaatcaaa 318 <210> 61 <211> 574 <212> PRT <213> Secuencia Artificial <220> <223> Sintética <400> 61 Met Cys Pro Arg Ala Ala Arg Ala Pro Ala Thr Leu Leu Leu Ala Leu 1 5 10 15 Gly Ala Val Leu Trp Pro Ala Ala Gly Ala Trp Glu Leu Thr Ile Leu 20 25 30 His Thr Asn Asp Val His Ser Arg Leu Glu Gln Thr Ser Glu Asp Ser 35 40 45 Ser Lys Cys Val Asn Ala Ser Arg Cys Met Gly Gly Val Ala Arg Leu 50 55 60 Phe Thr Lys Val Gln Gln Ile Arg Arg Ala Glu Pro Asn Val Leu Leu 65 70 75 80 Leu Asp Ala Gly Asp Gln Tyr Gln Gly Thr Ile Trp Phe Thr Val Tyr 85 90 95 Lys Gly Ala Glu Val Ala His Phe Met Asn Ala Leu Arg Tyr Asp Ala 100 105 110 Met Ala Leu Gly Asn His Glu Phe Asp Asn Gly Val Glu Gly Leu Ile 115 120 125 Glu Pro Leu Leu Lys Glu Ala Lys Phe Pro Ile Leu Ser Ala Asn Ile 130 135 140 Lys Ala Lys Gly Pro Leu Ala Ser Gln Ile Ser Gly Leu Tyr Leu Pro 145 150 155 160 Tyr Lys Val Leu Pro Val Gly Asp Glu Val Val Gly Ile Val Gly Tyr 165 170 175 Thr Ser Lys Glu Thr Pro Phe Leu Ser Asn Pro Gly Thr Asn Leu Val 180 185 190 Phe Glu Asp Glu Ile Thr Ala Leu Gln Pro Glu Val Asp Lys Leu Lys 195 200 205 Thr Leu Asn Val Asn Lys Ile Ile Ala Leu Gly His Ser Gly Phe Glu 210 215 220 Met Asp Lys Leu Ile Ala Gln Lys Val Arg Gly Val Asp Val Val Val 225 230 235 240 Gly Gly His Ser Asn Thr Phe Leu Tyr Thr Gly Asn Pro Pro Ser Lys 245 250 255 Glu Val Pro Ala Gly Lys Tyr Pro Phe Ile Val Thr Ser Asp Asp Gly 260 265 270 Arg Lys Val Pro Val Val Gln Ala Tyr Ala Phe Gly Lys Tyr Leu Gly 275 280 285 Tyr Leu Lys Ile Glu Phe Asp Glu Arg Gly Asn Val Ile Ser Ser His 290 295 300 Gly Asn Pro Ile Leu Leu Asn Ser Ser Ile Pro Glu Asp Pro Ser Ile 305 310 315 320 Lys Ala Asp Ile Asn Lys Trp Arg Ile Lys Leu Asp Asn Tyr Ser Thr 325 330 335 Gln Glu Leu Gly Lys Thr Ile Val Tyr Leu Asp Gly Ser Ser Gln Ser 340 345 350 Cys Arg Phe Arg Glu Cys Asn Met Gly Asn Leu Ile Cys Asp Ala Met 355 360 365 Ile Asn Asn Asn Leu Arg His Thr Asp Glu Met Phe Trp Asn His Val 370 375 380 Ser Met Cys Ile Leu Asn Gly Gly Gly Ile Arg Ser Pro Ile Asp Glu 385 390 395 400 Arg Asn Asn Gly Thr Ile Thr Trp Glu Asn Leu Ala Ala Val Leu Pro 405 410 415 Phe Gly Gly Thr Phe Asp Leu Val Gln Leu Lys Gly Ser Thr Leu Lys 420 425 430 Lys Ala Phe Glu His Ser Val His Arg Tyr Gly Gln Ser Thr Gly Glu 435 440 445 Phe Leu Gln Val Gly Gly Ile His Val Val Tyr Asp Leu Ser Arg Lys 450 455 460 Pro Gly Asp Arg Val Val Lys Leu Asp Val Leu Cys Thr Lys Cys Arg 465 470 475 480 Val Pro Ser Tyr Asp Pro Leu Lys Met Asp Glu Val Tyr Lys Val Ile 485 490 495 Leu Pro Asn Phe Leu Ala Asn Gly Gly Asp Gly Phe Gln Met Ile Lys 500 505 510 Asp Glu Leu Leu Arg His Asp Ser Gly Asp Gln Asp Ile Asn Val Val 515 520 525 Ser Thr Tyr Ile Ser Lys Met Lys Val Ile Tyr Pro Ala Val Glu Gly 530 535 540 Arg Ile Lys Phe Ser Thr Gly Ser His Cys His Gly Ser Phe Ser Leu 545 550 555 560 Ile Phe Leu Ser Leu Trp Ala Val Ile Phe Val Leu Tyr Gln 565 570