LISTADO DE SECUENCIAS <110> argenx BVBA <120> ANTICUERPOS ANTI-GARP-TGF-? <130> N415743WO <140> PCT/EP2018/062251 <141> 2018-05-11 <150> GB1707561.5 <151> 2017-05-11 <160> 48 <170> PatentIn versión 3.5 <210> 1 <211> 126 <212> PRT <213> Llama glama <400> 1 Glu Val Gln Leu Val Gln Pro Gly Ala Glu Leu Arg Asn Ser Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Arg Phe Thr Ser Tyr 20 25 30 Tyr Ile Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Asp Pro Glu Asp Gly Gly Thr Lys Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Phe Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 65 70 75 80 Val Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asn Glu Trp Glu Thr Val Val Val Gly Asp Leu Met Tyr Glu 100 105 110 Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 115 120 125 <210> 2 <211> 107 <212> PRT <213> Llama glama <400> 2 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Arg Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Ser Phe Thr Leu Thr Ile Ser Gly Leu Glu Ala 65 70 75 80 Glu Asp Ala Gly Thr Tyr Tyr Cys Gln Gln Tyr Asp Ser Leu Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Leu Lys 100 105 <210> 3 <211> 107 <212> PRT <213> Llama glama <400> 3 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Asn Ile Leu Ile 35 40 45 Tyr Gly Ala Ser Arg Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Ser Phe Thr Leu Thr Ile Ser Gly Leu Glu Ala 65 70 75 80 Glu Asp Ala Gly Thr Tyr Tyr Cys Gln Gln Tyr Ala Ser Val Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Leu Lys 100 105 <210> 4 <211> 5 <212> PRT <213> Llama glama <400> 4 Ser Tyr Tyr Ile Asp 1 5 <210> 5 <211> 17 <212> PRT <213> Llama glama <400> 5 Arg Ile Asp Pro Glu Asp Gly Gly Thr Lys Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 6 <211> 17 <212> PRT <213> Llama glama <400> 6 Asn Glu Trp Glu Thr Val Val Val Gly Asp Leu Met Tyr Glu Tyr Glu 1 5 10 15 Tyr <210> 7 <211> 17 <212> PRT <213> Llama glama <400> 7 Arg Ile Asp Pro Glu Glu Gly Gly Thr Lys Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 8 <211> 17 <212> PRT <213> Llama glama <400> 8 Arg Ile Asp Pro Glu Asp Ala Gly Thr Lys Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 9 <211> 11 <212> PRT <213> Llama glama <400> 9 Gln Ala Ser Gln Ser Ile Ser Ser Tyr Leu Ala 1 5 10 <210> 10 <211> 7 <212> PRT <213> Llama glama <400> 10 Gly Ala Ser Arg Leu Lys Thr 1 5 <210> 11 <211> 9 <212> PRT <213> Llama glama <400> 11 Gln Gln Tyr Ala Ser Val Pro Val Thr 1 5 <210> 12 <211> 17 <212> PRT <213> Artificial <220> <223> fragmento de anticuerpo <400> 12 Arg Ile Asp Pro Glu Asp Ala Gly Thr Lys Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 13 <211> 17 <212> PRT <213> Artificial <220> <223> fragmento de anticuerpo <400> 13 Tyr Glu Trp Glu Thr Val Val Val Gly Asp Leu Met Tyr Glu Tyr Glu 1 5 10 15 Tyr <210> 14 <211> 126 <212> PRT <213> Artificial <220> <223> fragmento de anticuerpo <400> 14 Gln Val Gln Leu Val Gln Pro Gly Ala Glu Val Arg Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Arg Phe Thr Ser Tyr 20 25 30 Tyr Ile Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Asp Pro Glu Asp Ala Gly Thr Lys Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Val Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Tyr Glu Trp Glu Thr Val Val Val Gly Asp Leu Met Tyr Glu 100 105 110 Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 15 <211> 107 <212> PRT <213> Artificial <220> <223> fragmento de anticuerpo <400> 15 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Ile Leu Ile 35 40 45 Tyr Gly Ala Ser Arg Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Ser Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr Ala Ser Val Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 16 <211> 452 <212> PRT <213> Artificial <220> <223> fragmento de anticuerpo <400> 16 Gln Val Gln Leu Val Gln Pro Gly Ala Glu Val Arg Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Arg Phe Thr Ser Tyr 20 25 30 Tyr Ile Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Asp Pro Glu Asp Ala Gly Thr Lys Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Val Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Tyr Glu Trp Glu Thr Val Val Val Gly Asp Leu Met Tyr Glu 100 105 110 Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 115 120 125 Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr 130 135 140 Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 145 150 155 160 Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 165 170 175 His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 180 185 190 Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr 195 200 205 Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 210 215 220 Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 225 230 235 240 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 245 250 255 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 260 265 270 Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 275 280 285 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 290 295 300 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 305 310 315 320 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 325 330 335 Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 340 345 350 Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 355 360 365 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 370 375 380 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 385 390 395 400 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 405 410 415 Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 420 425 430 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 435 440 445 Leu Ser Leu Gly 450 <210> 17 <211> 214 <212> PRT <213> Artificial <220> <223> fragmento de anticuerpo <400> 17 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Ile Leu Ile 35 40 45 Tyr Gly Ala Ser Arg Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Ser Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr Ala Ser Val Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 100 105 110 Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 115 120 125 Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 130 135 140 Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 145 150 155 160 Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 165 170 175 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 180 185 190 Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 195 200 205 Phe Asn Arg Gly Glu Cys 210 <210> 18 <211> 378 <212> ADN <213> Artificial <220> <223> fragmento de anticuerpo <400> 18 caagtccaac ttgtccaacc gggggcggaa gtgcggaagc cgggggcgag cgtgaaagtc 60 tcgtgcaagg catcgggata ccgattcaca tcatattaca tcgactgggt caggcaagcg 120 ccggggcaag ggctggaatg gatggggcgg atcgacccgg aggatgccgg gacgaaatat 180 gcgcaaaaat tccaagggcg cgtcacgatg acggccgaca catcgacgag cacggtatac 240 gtggagctga gctcgctgag gagcgaggac accgcggtat actactgcgc gcgatacgaa 300 tgggagaccg tcgtcgtcgg ggacctgatg tacgaatacg aatactgggg gcaagggacg 360 cttgtcacgg tctcgagc 378 <210> 19 <211> 321 <212> ADN <213> Artificial <220> <223> fragmento de anticuerpo <400> 19 gacatccaga tgactcagag cccttccagc ctgagcgcct ctgtgggaga tagagtcacc 60 atcacatgcc aggctagtca gtcaatttct agttacctgg catggtatca gcagaagcct 120 ggccaggcac ctaaaatcct gatctacgga gccagtaggc tgaagacagg ggtgccatct 180 cggttctccg gcagcggatc tgggacatcc tttactctga ccatctcatc cctggagcca 240 gaagacgccg ctacatacta ttgtcagcag tatgcttccg tgcccgtcac attcggtcag 300 ggcactaagg tcgagatcaa g 321 <210> 20 <211> 420 <212> ADN <213> Artificial <220> <223> fragmento de anticuerpo <400> 20 caagtccaac ttgtccaacc gggggcggaa gtgcggaagc cgggggcgag cgtgaaagtc 60 tcgtgcaagg catcgggata ccgattcaca tcatattaca tcgactgggt caggcaagcg 120 ccggggcaag ggctggaatg gatggggcgg atcgacccgg aggatgccgg gacgaaatat 180 gcgcaaaaat tccaagggcg cgtcacgatg acggccgaca catcgacgag cacggtatac 240 gtggagctga gctcgctgag gagcgaggac accgcggtat actactgcgc gcgatacgaa 300 tgggagaccg tcgtcgtcgg ggacctgatg tacgaatacg aatactgggg gcaagggacg 360 cttgtcacgg tctcgagcgc tagcaccaag ggcccctccg tgttccccct ggccccttgc 420 <210> 21 <211> 936 <212> ADN <213> Artificial <220> <223> fragmento de anticuerpo <400> 21 tcccggtcca cctccgagtc taccgccgct ctgggctgcc tggtgaaaga ctacttcccc 60 gagcctgtga ccgtgagctg gaactctggc gccctgacct ccggcgtgca caccttccct 120 gccgtgctgc aatcctccgg cctgtactcc ctgtcctccg tggtgacagt gccctcctcc 180 agcctgggca ccaagaccta cacctgtaac gtggaccaca agccctccaa caccaaggtg 240 gacaagcggg tggaatctaa atacggccct ccctgccccc cctgccctgc ccctgaattt 300 ctgggcggac cttccgtgtt tctgttcccc ccaaagccca aggacaccct gatgatctcc 360 cggacccccg aagtgacctg cgtggtggtg gacgtgtccc aggaagatcc agaggtgcag 420 ttcaactggt atgttgacgg cgtggaagtg cacaacgcca agaccaagcc cagagaggaa 480 cagttcaact ccacctaccg ggtggtgtcc gtgctgaccg tgctgcacca ggactggctg 540 aacggcaaag agtacaagtg caaggtgtcc aacaagggcc tgccctccag catcgaaaag 600 accatctcca aggccaaggg ccagccccgc gagccccagg tgtacaccct gccccctagc 660 caggaagaga tgaccaagaa ccaggtgtcc ctgacctgtc tggtgaaagg cttctacccc 720 tccgacattg ccgtggaatg ggagtccaac ggccagcccg agaacaacta caagaccacc 780 ccccctgtgc tggactccga cggctccttc ttcctgtact ctcggctgac agtggataag 840 tcccggtggc aggaaggcaa cgtgttctcc tgcagcgtga tgcacgaggc cctgcacaac 900 cactataccc agaagtccct gtccctgagc ctgggc 936 <210> 22 <211> 126 <212> PRT <213> Artificial <220> <223> fragmento de anticuerpo <400> 22 Gln Val Gln Leu Val Gln Pro Gly Ala Glu Val Arg Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Arg Phe Thr Ser Tyr 20 25 30 Tyr Ile Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Asp Pro Glu Asp Gly Gly Thr Lys Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Val Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asn Glu Trp Glu Thr Val Val Val Gly Asp Leu Met Tyr Glu 100 105 110 Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 23 <211> 107 <212> PRT <213> Artificial <220> <223> fragmento de anticuerpo <400> 23 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Ile Leu Ile 35 40 45 Tyr Gly Ala Ser Arg Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Ser Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr Ala Ser Val Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 24 <211> 126 <212> PRT <213> Artificial <220> <223> fragmento de anticuerpo <400> 24 Glu Val Gln Leu Val Gln Pro Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Arg Phe Thr Ser Tyr 20 25 30 Tyr Ile Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Asp Pro Glu Glu Gly Gly Thr Lys Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Phe Thr Ala Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Val Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asn Glu Trp Glu Thr Val Val Val Gly Asp Leu Thr Tyr Glu 100 105 110 Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 25 <211> 107 <212> PRT <213> Artificial <220> <223> fragmento de anticuerpo <400> 25 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Ile Leu Ile 35 40 45 Tyr Gly Ala Ser Arg Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ala Ser Val Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 26 <211> 126 <212> PRT <213> Artificial <220> <223> fragmento de anticuerpo <400> 26 Gln Val Gln Leu Val Gln Pro Gly Ala Glu Leu Arg Asn Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Arg Phe Thr Ser Tyr 20 25 30 Tyr Ile Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Asp Pro Glu Asp Gly Gly Thr Lys Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Phe Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asn Glu Trp Glu Thr Val Val Val Gly Asp Leu Met Tyr Glu 100 105 110 Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 27 <211> 107 <212> PRT <213> Artificial <220> <223> fragmento de anticuerpo <400> 27 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Arg Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr Ala Ser Val Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 28 <211> 126 <212> PRT <213> Artificial <220> <223> fragmento de anticuerpo <400> 28 Gln Val Gln Leu Val Gln Pro Gly Ala Glu Leu Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Arg Phe Thr Ser Tyr 20 25 30 Tyr Ile Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Asp Pro Glu Asp Ala Gly Thr Lys Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Phe Thr Ala Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Val Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asn Glu Trp Glu Thr Val Val Val Gly Asp Leu Thr Tyr Glu 100 105 110 Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 29 <211> 106 <212> PRT <213> Artificial <220> <223> fragmento de anticuerpo <400> 29 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Arg Leu Lys Thr Glu Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Ile Ser Gly Leu Glu Pro Glu 65 70 75 80 Asp Ala Gly Thr Tyr Tyr Cys Gln Gln Tyr Ala Ser Val Pro Val Thr 85 90 95 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 30 <211> 126 <212> PRT <213> Artificial <220> <223> fragmento de anticuerpo <400> 30 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Arg Phe Thr Ser Tyr 20 25 30 Tyr Ile Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Asp Pro Glu Glu Gly Gly Thr Lys Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asn Glu Trp Glu Thr Val Val Val Gly Asp Leu Met Tyr Glu 100 105 110 Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 31 <211> 107 <212> PRT <213> Artificial <220> <223> fragmento de anticuerpo <400> 31 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Asn Ile Leu Ile 35 40 45 Tyr Gly Ala Ser Arg Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Gly Leu Glu Ala 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ala Ser Val Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 32 <211> 17 <212> PRT <213> Artificial <220> <223> fragmento de anticuerpo <400> 32 Asn Glu Trp Glu Thr Val Val Val Gly Asp Leu Thr Tyr Glu Tyr Glu 1 5 10 15 Tyr <210> 33 <211> 662 <212> PRT <213> Homo sapiens <400> 33 Met Arg Pro Gln Ile Leu Leu Leu Leu Ala Leu Leu Thr Leu Gly Leu 1 5 10 15 Ala Ala Gln His Gln Asp Lys Val Pro Cys Lys Met Val Asp Lys Lys 20 25 30 Val Ser Cys Gln Val Leu Gly Leu Leu Gln Val Pro Ser Val Leu Pro 35 40 45 Pro Asp Thr Glu Thr Leu Asp Leu Ser Gly Asn Gln Leu Arg Ser Ile 50 55 60 Leu Ala Ser Pro Leu Gly Phe Tyr Thr Ala Leu Arg His Leu Asp Leu 65 70 75 80 Ser Thr Asn Glu Ile Ser Phe Leu Gln Pro Gly Ala Phe Gln Ala Leu 85 90 95 Thr His Leu Glu His Leu Ser Leu Ala His Asn Arg Leu Ala Met Ala 100 105 110 Thr Ala Leu Ser Ala Gly Gly Leu Gly Pro Leu Pro Arg Val Thr Ser 115 120 125 Leu Asp Leu Ser Gly Asn Ser Leu Tyr Ser Gly Leu Leu Glu Arg Leu 130 135 140 Leu Gly Glu Ala Pro Ser Leu His Thr Leu Ser Leu Ala Glu Asn Ser 145 150 155 160 Leu Thr Arg Leu Thr Arg His Thr Phe Arg Asp Met Pro Ala Leu Glu 165 170 175 Gln Leu Asp Leu His Ser Asn Val Leu Met Asp Ile Glu Asp Gly Ala 180 185 190 Phe Glu Gly Leu Pro Arg Leu Thr His Leu Asn Leu Ser Arg Asn Ser 195 200 205 Leu Thr Cys Ile Ser Asp Phe Ser Leu Gln Gln Leu Arg Val Leu Asp 210 215 220 Leu Ser Cys Asn Ser Ile Glu Ala Phe Gln Thr Ala Ser Gln Pro Gln 225 230 235 240 Ala Glu Phe Gln Leu Thr Trp Leu Asp Leu Arg Glu Asn Lys Leu Leu 245 250 255 His Phe Pro Asp Leu Ala Ala Leu Pro Arg Leu Ile Tyr Leu Asn Leu 260 265 270 Ser Asn Asn Leu Ile Arg Leu Pro Thr Gly Pro Pro Gln Asp Ser Lys 275 280 285 Gly Ile His Ala Pro Ser Glu Gly Trp Ser Ala Leu Pro Leu Ser Ala 290 295 300 Pro Ser Gly Asn Ala Ser Gly Arg Pro Leu Ser Gln Leu Leu Asn Leu 305 310 315 320 Asp Leu Ser Tyr Asn Glu Ile Glu Leu Ile Pro Asp Ser Phe Leu Glu 325 330 335 His Leu Thr Ser Leu Cys Phe Leu Asn Leu Ser Arg Asn Cys Leu Arg 340 345 350 Thr Phe Glu Ala Arg Arg Leu Gly Ser Leu Pro Cys Leu Met Leu Leu 355 360 365 Asp Leu Ser His Asn Ala Leu Glu Thr Leu Glu Leu Gly Ala Arg Ala 370 375 380 Leu Gly Ser Leu Arg Thr Leu Leu Leu Gln Gly Asn Ala Leu Arg Asp 385 390 395 400 Leu Pro Pro Tyr Thr Phe Ala Asn Leu Ala Ser Leu Gln Arg Leu Asn 405 410 415 Leu Gln Gly Asn Arg Val Ser Pro Cys Gly Gly Pro Asp Glu Pro Gly 420 425 430 Pro Ser Gly Cys Val Ala Phe Ser Gly Ile Thr Ser Leu Arg Ser Leu 435 440 445 Ser Leu Val Asp Asn Glu Ile Glu Leu Leu Arg Ala Gly Ala Phe Leu 450 455 460 His Thr Pro Leu Thr Glu Leu Asp Leu Ser Ser Asn Pro Gly Leu Glu 465 470 475 480 Val Ala Thr Gly Ala Leu Gly Gly Leu Glu Ala Ser Leu Glu Val Leu 485 490 495 Ala Leu Gln Gly Asn Gly Leu Met Val Leu Gln Val Asp Leu Pro Cys 500 505 510 Phe Ile Cys Leu Lys Arg Leu Asn Leu Ala Glu Asn Arg Leu Ser His 515 520 525 Leu Pro Ala Trp Thr Gln Ala Val Ser Leu Glu Val Leu Asp Leu Arg 530 535 540 Asn Asn Ser Phe Ser Leu Leu Pro Gly Ser Ala Met Gly Gly Leu Glu 545 550 555 560 Thr Ser Leu Arg Arg Leu Tyr Leu Gln Gly Asn Pro Leu Ser Cys Cys 565 570 575 Gly Asn Gly Trp Leu Ala Ala Gln Leu His Gln Gly Arg Val Asp Val 580 585 590 Asp Ala Thr Gln Asp Leu Ile Cys Arg Phe Ser Ser Gln Glu Glu Val 595 600 605 Ser Leu Ser His Val Arg Pro Glu Asp Cys Glu Lys Gly Gly Leu Lys 610 615 620 Asn Ile Asn Leu Ile Ile Ile Leu Thr Phe Ile Leu Val Ser Ala Ile 625 630 635 640 Leu Leu Thr Thr Leu Ala Ala Cys Cys Cys Val Arg Arg Gln Lys Phe 645 650 655 Asn Gln Gln Tyr Lys Ala 660 <210> 34 <211> 390 <212> PRT <213> Homo sapiens <400> 34 Met Pro Pro Ser Gly Leu Arg Leu Leu Pro Leu Leu Leu Pro Leu Leu 1 5 10 15 Trp Leu Leu Val Leu Thr Pro Gly Arg Pro Ala Ala Gly Leu Ser Thr 20 25 30 Cys Lys Thr Ile Asp Met Glu Leu Val Lys Arg Lys Arg Ile Glu Ala 35 40 45 Ile Arg Gly Gln Ile Leu Ser Lys Leu Arg Leu Ala Ser Pro Pro Ser 50 55 60 Gln Gly Glu Val Pro Pro Gly Pro Leu Pro Glu Ala Val Leu Ala Leu 65 70 75 80 Tyr Asn Ser Thr Arg Asp Arg Val Ala Gly Glu Ser Ala Glu Pro Glu 85 90 95 Pro Glu Pro Glu Ala Asp Tyr Tyr Ala Lys Glu Val Thr Arg Val Leu 100 105 110 Met Val Glu Thr His Asn Glu Ile Tyr Asp Lys Phe Lys Gln Ser Thr 115 120 125 His Ser Ile Tyr Met Phe Phe Asn Thr Ser Glu Leu Arg Glu Ala Val 130 135 140 Pro Glu Pro Val Leu Leu Ser Arg Ala Glu Leu Arg Leu Leu Arg Leu 145 150 155 160 Lys Leu Lys Val Glu Gln His Val Glu Leu Tyr Gln Lys Tyr Ser Asn 165 170 175 Asn Ser Trp Arg Tyr Leu Ser Asn Arg Leu Leu Ala Pro Ser Asp Ser 180 185 190 Pro Glu Trp Leu Ser Phe Asp Val Thr Gly Val Val Arg Gln Trp Leu 195 200 205 Ser Arg Gly Gly Glu Ile Glu Gly Phe Arg Leu Ser Ala His Cys Ser 210 215 220 Cys Asp Ser Arg Asp Asn Thr Leu Gln Val Asp Ile Asn Gly Phe Thr 225 230 235 240 Thr Gly Arg Arg Gly Asp Leu Ala Thr Ile His Gly Met Asn Arg Pro 245 250 255 Phe Leu Leu Leu Met Ala Thr Pro Leu Glu Arg Ala Gln His Leu Gln 260 265 270 Ser Ser Arg His Arg Arg Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser 275 280 285 Thr Glu Lys Asn Cys Cys Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys 290 295 300 Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly Tyr His Ala Asn 305 310 315 320 Phe Cys Leu Gly Pro Cys Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr 325 330 335 Ser Lys Val Leu Ala Leu Tyr Asn Gln His Asn Pro Gly Ala Ser Ala 340 345 350 Ala Pro Cys Cys Val Pro Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr 355 360 365 Tyr Val Gly Arg Lys Pro Lys Val Glu Gln Leu Ser Asn Met Ile Val 370 375 380 Arg Ser Cys Lys Cys Ser 385 390 <210> 35 <211> 249 <212> PRT <213> Homo sapiens <400> 35 Leu Ser Thr Cys Lys Thr Ile Asp Met Glu Leu Val Lys Arg Lys Arg 1 5 10 15 Ile Glu Ala Ile Arg Gly Gln Ile Leu Ser Lys Leu Arg Leu Ala Ser 20 25 30 Pro Pro Ser Gln Gly Glu Val Pro Pro Gly Pro Leu Pro Glu Ala Val 35 40 45 Leu Ala Leu Tyr Asn Ser Thr Arg Asp Arg Val Ala Gly Glu Ser Ala 50 55 60 Glu Pro Glu Pro Glu Pro Glu Ala Asp Tyr Tyr Ala Lys Glu Val Thr 65 70 75 80 Arg Val Leu Met Val Glu Thr His Asn Glu Ile Tyr Asp Lys Phe Lys 85 90 95 Gln Ser Thr His Ser Ile Tyr Met Phe Phe Asn Thr Ser Glu Leu Arg 100 105 110 Glu Ala Val Pro Glu Pro Val Leu Leu Ser Arg Ala Glu Leu Arg Leu 115 120 125 Leu Arg Leu Lys Leu Lys Val Glu Gln His Val Glu Leu Tyr Gln Lys 130 135 140 Tyr Ser Asn Asn Ser Trp Arg Tyr Leu Ser Asn Arg Leu Leu Ala Pro 145 150 155 160 Ser Asp Ser Pro Glu Trp Leu Ser Phe Asp Val Thr Gly Val Val Arg 165 170 175 Gln Trp Leu Ser Arg Gly Gly Glu Ile Glu Gly Phe Arg Leu Ser Ala 180 185 190 His Cys Ser Cys Asp Ser Arg Asp Asn Thr Leu Gln Val Asp Ile Asn 195 200 205 Gly Phe Thr Thr Gly Arg Arg Gly Asp Leu Ala Thr Ile His Gly Met 210 215 220 Asn Arg Pro Phe Leu Leu Leu Met Ala Thr Pro Leu Glu Arg Ala Gln 225 230 235 240 His Leu Gln Ser Ser Arg His Arg Arg 245 <210> 36 <211> 112 <212> PRT <213> Homo sapiens <400> 36 Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser Thr Glu Lys Asn Cys Cys 1 5 10 15 Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys Asp Leu Gly Trp Lys Trp 20 25 30 Ile His Glu Pro Lys Gly Tyr His Ala Asn Phe Cys Leu Gly Pro Cys 35 40 45 Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr Ser Lys Val Leu Ala Leu 50 55 60 Tyr Asn Gln His Asn Pro Gly Ala Ser Ala Ala Pro Cys Cys Val Pro 65 70 75 80 Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr Tyr Val Gly Arg Lys Pro 85 90 95 Lys Val Glu Gln Leu Ser Asn Met Ile Val Arg Ser Cys Lys Cys Ser 100 105 110 <210> 37 <211> 10 <212> PRT <213> Homo sapiens <400> 37 Glu Pro Lys Ser Cys Asp Lys Thr His Thr 1 5 10 <210> 38 <211> 5 <212> PRT <213> Homo sapiens <400> 38 Cys Pro Pro Cys Pro 1 5 <210> 39 <211> 8 <212> PRT <213> Homo sapiens <400> 39 Ala Pro Glu Leu Leu Gly Gly Pro 1 5 <210> 40 <211> 12 <212> PRT <213> Homo sapiens <400> 40 Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr 1 5 10 <210> 41 <211> 50 <212> PRT <213> Homo sapiens <400> 41 Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys 1 5 10 15 Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro 20 25 30 Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 35 40 45 Cys Pro 50 <210> 42 <211> 8 <212> PRT <213> Homo sapiens <400> 42 Ala Pro Glu Leu Leu Gly Gly Pro 1 5 <210> 43 <211> 7 <212> PRT <213> Homo sapiens <400> 43 Glu Ser Lys Tyr Gly Pro Pro 1 5 <210> 44 <211> 5 <212> PRT <213> Homo sapiens <400> 44 Cys Pro Ser Cys Pro 1 5 <210> 45 <211> 8 <212> PRT <213> Homo sapiens <400> 45 Ala Pro Glu Phe Leu Gly Gly Pro 1 5 <210> 46 <211> 3 <212> PRT <213> Homo sapiens <400> 46 Glu Arg Lys 1 <210> 47 <211> 10 <212> PRT <213> Homo sapiens <400> 47 Cys Cys Val Glu Cys Pro Pro Pro Cys Pro 1 5 10 <210> 48 <211> 7 <212> PRT <213> Homo sapiens <400> 48 Ala Pro Pro Val Ala Gly Pro 1 5