o;? SEQUENCE LISTING <110> JOINT STOCK COMPANY "BIOCAD" <120> ANTIBODIES SPECIFIC TO CD47 AND PD-L1 <140> EA201791961 <141> 2017-10-03 <160> 108 <170> BiSSAP 1.3.6 <210> 1 <211> 5 <212> PRT <213> Artificial Sequence <400> 1 Arg Tyr Trp Met Tyr 1 5 <210> 2 <211> 5 <212> PRT <213> Artificial Sequence <400> 2 Ile Asn Ala Met Asn 1 5 <210> 3 <211> 5 <212> PRT <213> Artificial Sequence <400> 3 Lys Tyr Trp Met Tyr 1 5 <210> 4 <211> 9 <212> PRT <213> Artificial Sequence <400> 4 Ser Ile Phe Ser Ile Asn Ala Met Asn 1 5 <210> 5 <211> 5 <212> PRT <213> Artificial Sequence <400> 5 Asp Tyr Ala Met Ser 1 5 <210> 6 <211> 23 <212> PRT <213> Artificial Sequence <400> 6 Ile Glu Asp Ser Ser Ile Asn Thr Gly Gly Gly Thr Glu Thr Thr Tyr 1 5 10 15 Tyr Thr Asp Ser Val Lys Gly 20 <210> 7 <211> 24 <212> PRT <213> Artificial Sequence <400> 7 Ser Ile Glu Asp Ser Ser Ile Asn Thr Gly Gly Gly Thr Glu Thr Thr 1 5 10 15 Tyr Tyr Thr Asp Ser Val Lys Gly 20 <210> 8 <211> 24 <212> PRT <213> Artificial Sequence <400> 8 Asn Ile Lys Gln Asp Gly Ile Asn Thr Gly Gly Gly Thr Ser Glu Lys 1 5 10 15 Tyr Tyr Val Asp Ser Val Lys Gly 20 <210> 9 <211> 17 <212> PRT <213> Artificial Sequence <400> 9 Ser Ile Glu Asp Ser Ser Glu Thr Thr Tyr Tyr Thr Asp Ser Val Lys 1 5 10 15 Gly <210> 10 <211> 16 <212> PRT <213> Artificial Sequence <400> 10 Gln Ile Thr Asp Glu Gly Ile Thr Asn Tyr Val Asp Ser Val Lys Gly 1 5 10 15 <210> 11 <211> 18 <212> PRT <213> Artificial Sequence <400> 11 Ser Ile Glu Asp Ser Ser Thr Glu Thr Thr Tyr Tyr Thr Asp Ser Val 1 5 10 15 Lys Gly <210> 12 <211> 19 <212> PRT <213> Artificial Sequence <400> 12 Ser Ile Glu Asp Ser Ser Ile Thr Glu Thr Thr Tyr Tyr Thr Asp Ser 1 5 10 15 Val Lys Gly <210> 13 <211> 18 <212> PRT <213> Artificial Sequence <400> 13 Ser Ile Asn Asp Gly Gly Gly Asp Asp Ser Thr Tyr Tyr Ala Asp Ser 1 5 10 15 Val Lys <210> 14 <211> 16 <212> PRT <213> Artificial Sequence <400> 14 Gly Ile Arg Thr Ser Gly Asp Thr Asp Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 15 <211> 16 <212> PRT <213> Artificial Sequence <400> 15 Gln Ile Thr Asp Glu Gly Ile Thr Asn Tyr Val Asp Ser Val Lys Gly 1 5 10 15 <210> 16 <211> 17 <212> PRT <213> Artificial Sequence <400> 16 Asp Ile Ser Trp Ser Gly Ser Asn Thr Asn Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 17 <211> 18 <212> PRT <213> Artificial Sequence <400> 17 Gly Asp Tyr Tyr Cys Thr Thr Tyr Glu Cys Gln His Tyr Tyr Gly Met 1 5 10 15 Asp Tyr <210> 18 <211> 9 <212> PRT <213> Artificial Sequence <400> 18 Val Ile Thr Thr Thr Ser Glu Ile Tyr 1 5 <210> 19 <211> 18 <212> PRT <213> Artificial Sequence <400> 19 Gly Asp Tyr Tyr Cys Thr His Tyr Glu Cys Gln His Tyr Tyr Gly Met 1 5 10 15 Asp Tyr <210> 20 <211> 12 <212> PRT <213> Artificial Sequence <400> 20 Asn Ala Phe Val Ile Thr Thr Thr Ser Glu Ile Tyr 1 5 10 <210> 21 <211> 13 <212> PRT <213> Artificial Sequence <400> 21 Ala Pro Leu Leu Leu Ala Met Thr Phe Gly Val Gly Ser 1 5 10 <210> 22 <211> 11 <212> PRT <213> Artificial Sequence <400> 22 Arg Ala Ser Gln Ala Ile Ser Ser Tyr Leu Ala 1 5 10 <210> 23 <211> 11 <212> PRT <213> Artificial Sequence <400> 23 Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 1 5 10 <210> 24 <211> 11 <212> PRT <213> Artificial Sequence <400> 24 Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 1 5 10 <210> 25 <211> 11 <212> PRT <213> Artificial Sequence <400> 25 Arg Ala Ser Gln Asp Ile Gly Ser Trp Leu Ala 1 5 10 <210> 26 <211> 11 <212> PRT <213> Artificial Sequence <400> 26 Arg Ala Ser Gln Ser Ile Ser Arg Asn Leu Asn 1 5 10 <210> 27 <211> 11 <212> PRT <213> Artificial Sequence <400> 27 Arg Ala Ser Gln His Ile Ser Ser Trp Leu Ala 1 5 10 <210> 28 <211> 11 <212> PRT <213> Artificial Sequence <400> 28 Arg Ala Ser Gln Ser Ile Ser His Tyr Leu Asn 1 5 10 <210> 29 <211> 11 <212> PRT <213> Artificial Sequence <400> 29 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 30 <211> 12 <212> PRT <213> Artificial Sequence <400> 30 Arg Ala Ser Gln Ser Val Ser Ser Asn Tyr Leu Ala 1 5 10 <210> 31 <211> 13 <212> PRT <213> Artificial Sequence <400> 31 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 32 <211> 11 <212> PRT <213> Artificial Sequence <400> 32 Gln Gly Asp Arg Ile Glu Asn Tyr Tyr Thr Ser 1 5 10 <210> 33 <211> 13 <212> PRT <213> Artificial Sequence <400> 33 Thr Gly Ser Ser Ser Asn Ile Gly Asp Asn Tyr Val Asn 1 5 10 <210> 34 <211> 16 <212> PRT <213> Artificial Sequence <400> 34 Thr Ser Ser Gln Ser Leu Val Tyr Arg Asp Gly Asn Thr Tyr Leu Asn 1 5 10 15 <210> 35 <211> 14 <212> PRT <213> Artificial Sequence <400> 35 Gly Leu Ser Ser Gly Thr Val Thr Ala Ile Asn Tyr Pro Gly 1 5 10 <210> 36 <211> 7 <212> PRT <213> Artificial Sequence <400> 36 Ala Ala Ser Asn Leu Gln Ser 1 5 <210> 37 <211> 7 <212> PRT <213> Artificial Sequence <400> 37 Ala Ala Ser Ser Leu Gln Ser 1 5 <210> 38 <211> 7 <212> PRT <213> Artificial Sequence <400> 38 Ala Ala Ser Thr Leu Gln Arg 1 5 <210> 39 <211> 7 <212> PRT <213> Artificial Sequence <400> 39 Thr Ala Ser Thr Leu Gln Ser 1 5 <210> 40 <211> 7 <212> PRT <213> Artificial Sequence <400> 40 Ala Ala Thr Arg Leu Gln Ser 1 5 <210> 41 <211> 7 <212> PRT <213> Artificial Sequence <400> 41 Asp Thr Ser Asn Arg Ala Thr 1 5 <210> 42 <211> 7 <212> PRT <213> Artificial Sequence <400> 42 Gly Thr Ser Ser Arg Ala Thr 1 5 <210> 43 <211> 7 <212> PRT <213> Artificial Sequence <400> 43 Ala Ser Ser Thr Leu Gln Ser 1 5 <210> 44 <211> 7 <212> PRT <213> Artificial Sequence <400> 44 Asp Asn Tyr Arg Arg Pro Ser 1 5 <210> 45 <211> 7 <212> PRT <213> Artificial Sequence <400> 45 Gly Asn Ala Asn Arg Pro Ser 1 5 <210> 46 <211> 7 <212> PRT <213> Artificial Sequence <400> 46 Ser Asn Ser Asn Arg Ala Ser 1 5 <210> 47 <211> 7 <212> PRT <213> Artificial Sequence <400> 47 Lys Val Ser Asp Arg Asp Ser 1 5 <210> 48 <211> 7 <212> PRT <213> Artificial Sequence <400> 48 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 49 <211> 7 <212> PRT <213> Artificial Sequence <400> 49 Asn Thr Asn Thr Arg His Ser 1 5 <210> 50 <211> 9 <212> PRT <213> Artificial Sequence <400> 50 Gln Gln Ala Ala Ser Val Pro Leu Thr 1 5 <210> 51 <211> 9 <212> PRT <213> Artificial Sequence <400> 51 Gln Gln Ser Tyr Ser Thr Pro Phe Thr 1 5 <210> 52 <211> 9 <212> PRT <213> Artificial Sequence <400> 52 Gln Gln Ser Tyr Ser Thr Pro Trp Thr 1 5 <210> 53 <211> 9 <212> PRT <213> Artificial Sequence <400> 53 Gln Gln Ser His Ser Leu Pro Leu Thr 1 5 <210> 54 <211> 9 <212> PRT <213> Artificial Sequence <400> 54 Gln Gln Ser Tyr Arg Thr Pro Phe Thr 1 5 <210> 55 <211> 9 <212> PRT <213> Artificial Sequence <400> 55 Gln Gln Ala Thr Ser Phe Pro Leu Thr 1 5 <210> 56 <211> 9 <212> PRT <213> Artificial Sequence <400> 56 Gln Gln Ser Tyr Ser Ala Leu Phe Thr 1 5 <210> 57 <211> 9 <212> PRT <213> Artificial Sequence <400> 57 Gln Gln Arg Ser Asn Trp Pro Pro Thr 1 5 <210> 58 <211> 9 <212> PRT <213> Artificial Sequence <400> 58 Gln Gln Ser Asp Thr Ser Pro Arg Val 1 5 <210> 59 <211> 10 <212> PRT <213> Artificial Sequence <400> 59 Gln Gln Ser Leu Ser Ile Pro Gln Val Thr 1 5 10 <210> 60 <211> 11 <212> PRT <213> Artificial Sequence <400> 60 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 61 <211> 9 <212> PRT <213> Artificial Sequence <400> 61 Gln Ser Gly Ser Ser Thr Glu Asn Ile 1 5 <210> 62 <211> 10 <212> PRT <213> Artificial Sequence <400> 62 Gln Ser Tyr Glu Ile Ser Gly Tyr Pro Val 1 5 10 <210> 63 <211> 9 <212> PRT <213> Artificial Sequence <400> 63 Met Gln Gly Thr His Trp Pro Ser Thr 1 5 <210> 64 <211> 10 <212> PRT <213> Artificial Sequence <400> 64 Gln Gln Tyr Gly Ser Ser Pro Gln Leu Thr 1 5 10 <210> 65 <211> 10 <212> PRT <213> Artificial Sequence <400> 65 Ala Leu Tyr Met Gly Asn Gly Gly His Met 1 5 10 <210> 66 <211> 134 <212> PRT <213> Artificial Sequence <400> 66 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Arg Tyr 20 25 30 Trp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Glu Asp Ser Ser Ile Asn Thr Gly Gly Gly Thr Glu Thr 50 55 60 Thr Tyr Tyr Thr Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 65 70 75 80 Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu 85 90 95 Asp Thr Ala Val Tyr Tyr Cys Ala Lys Gly Asp Tyr Tyr Cys Thr Thr 100 105 110 Tyr Glu Cys Gln His Tyr Tyr Gly Met Asp Tyr Trp Gly Lys Gly Thr 115 120 125 Met Val Thr Val Ser Ser 130 <210> 67 <211> 213 <212> PRT <213> Artificial Sequence <400> 67 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 20 25 30 Trp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Glu Asp Ser Ser Ile Asn Thr Gly Gly Gly Thr Glu Thr 50 55 60 Thr Tyr Tyr Thr Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 65 70 75 80 Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 85 90 95 Asp Thr Ala Val Tyr Tyr Cys Ala Lys Gly Asp Tyr Tyr Cys Thr Thr 100 105 110 Tyr Glu Cys Gln His Tyr Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr 115 120 125 Thr Val Thr Val Ser Ser 130 <210> 68 <211> 134 <212> PRT <213> Artificial Sequence <400> 68 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Arg Tyr 20 25 30 Trp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Glu Asp Ser Ser Ile Asn Thr Gly Gly Gly Thr Glu Thr 50 55 60 Thr Tyr Tyr Thr Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 65 70 75 80 Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu 85 90 95 Asp Thr Ala Val Tyr Tyr Cys Ala Lys Gly Asp Tyr Tyr Cys Thr Thr 100 105 110 Tyr Glu Cys Gln His Tyr Tyr Gly Met Asp Tyr Trp Gly Lys Gly Thr 115 120 125 Thr Val Thr Val Ser Ser 130 <210> 69 <211> 134 <212> PRT <213> Artificial Sequence <400> 69 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Arg Tyr 20 25 30 Trp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Glu Asp Ser Ser Ile Asn Thr Gly Gly Gly Thr Glu Thr 50 55 60 Thr Tyr Tyr Thr Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 65 70 75 80 Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu 85 90 95 Asp Thr Ala Val Tyr Tyr Cys Ala Lys Gly Asp Tyr Tyr Cys Thr Thr 100 105 110 Tyr Glu Cys Gln His Tyr Tyr Gly Met Asp Tyr Trp Gly Lys Gly Thr 115 120 125 Thr Val Thr Val Ser Ser 130 <210> 70 <211> 134 <212> PRT <213> Artificial Sequence <400> 70 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Arg Tyr 20 25 30 Trp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Glu Asp Ser Ser Ile Asn Thr Gly Gly Gly Thr Glu Thr 50 55 60 Thr Tyr Tyr Thr Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 65 70 75 80 Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu 85 90 95 Asp Thr Ala Val Tyr Tyr Cys Ala Lys Gly Asp Tyr Tyr Cys Thr Thr 100 105 110 Tyr Glu Cys Gln His Tyr Tyr Gly Met Asp Tyr Trp Gly Lys Gly Thr 115 120 125 Leu Val Thr Val Ser Ser 130 <210> 71 <211> 134 <212> PRT <213> Artificial Sequence <400> 71 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Arg Tyr 20 25 30 Trp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Glu Asp Ser Ser Ile Asn Thr Gly Gly Gly Thr Glu Thr 50 55 60 Thr Tyr Tyr Thr Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 65 70 75 80 Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu 85 90 95 Asp Thr Ala Val Tyr Tyr Cys Ala Lys Gly Asp Tyr Tyr Cys Thr Thr 100 105 110 Tyr Glu Cys Gln His Tyr Tyr Gly Met Asp Tyr Trp Gly Lys Gly Thr 115 120 125 Leu Val Thr Val Ser Ser 130 <210> 72 <211> 134 <212> PRT <213> Artificial Sequence <400> 72 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Arg Tyr 20 25 30 Trp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Glu Asp Ser Ser Ile Asn Thr Gly Gly Gly Thr Glu Thr 50 55 60 Thr Tyr Tyr Thr Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 65 70 75 80 Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu 85 90 95 Asp Thr Ala Val Tyr Tyr Cys Ala Lys Gly Asp Tyr Tyr Cys Thr Thr 100 105 110 Tyr Glu Cys Gln His Tyr Tyr Gly Met Asp Tyr Trp Gly Lys Gly Thr 115 120 125 Leu Val Thr Val Ser Ser 130 <210> 73 <211> 134 <212> PRT <213> Artificial Sequence <400> 73 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Arg Tyr 20 25 30 Trp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Glu Asp Ser Ser Ile Asn Thr Gly Gly Gly Thr Glu Thr 50 55 60 Thr Tyr Tyr Thr Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 65 70 75 80 Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu 85 90 95 Asp Thr Ala Val Tyr Tyr Cys Ala Lys Gly Asp Tyr Tyr Cys Thr Thr 100 105 110 Tyr Glu Cys Gln His Tyr Tyr Gly Met Asp Tyr Trp Gly Lys Gly Thr 115 120 125 Leu Val Thr Val Ser Ser 130 <210> 74 <211> 134 <212> PRT <213> Artificial Sequence <400> 74 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Arg Tyr 20 25 30 Trp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Glu Asp Ser Ser Ile Asn Thr Gly Gly Gly Thr Glu Thr 50 55 60 Thr Tyr Tyr Thr Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 65 70 75 80 Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu 85 90 95 Asp Thr Ala Val Tyr Tyr Cys Ala Lys Gly Asp Tyr Tyr Cys Thr Thr 100 105 110 Tyr Glu Cys Gln His Tyr Tyr Gly Met Asp Tyr Trp Gly Lys Gly Thr 115 120 125 Leu Val Thr Val Ser Ser 130 <210> 75 <211> 134 <212> PRT <213> Artificial Sequence <400> 75 Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Arg Tyr 20 25 30 Trp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Glu Asp Ser Ser Ile Asn Thr Gly Gly Gly Thr Glu Thr 50 55 60 Thr Tyr Tyr Thr Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 65 70 75 80 Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu 85 90 95 Asp Thr Ala Val Tyr Tyr Cys Ala Lys Gly Asp Tyr Tyr Cys Thr Thr 100 105 110 Tyr Glu Cys Gln His Tyr Tyr Gly Met Asp Tyr Trp Gly Lys Gly Thr 115 120 125 Met Val Thr Val Ser Ser 130 <210> 76 <211> 134 <212> PRT <213> Artificial Sequence <400> 76 Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Arg Tyr 20 25 30 Trp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Glu Asp Ser Ser Ile Asn Thr Gly Gly Gly Thr Glu Thr 50 55 60 Thr Tyr Tyr Thr Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 65 70 75 80 Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu 85 90 95 Asp Thr Ala Val Tyr Tyr Cys Ala Lys Gly Asp Tyr Tyr Cys Thr Thr 100 105 110 Tyr Glu Cys Gln His Tyr Tyr Gly Met Asp Tyr Trp Gly Lys Gly Thr 115 120 125 Met Val Thr Val Ser Ser 130 <210> 77 <211> 134 <212> PRT <213> Artificial Sequence <400> 77 Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Arg Tyr 20 25 30 Trp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Glu Asp Ser Ser Ile Asn Thr Gly Gly Gly Thr Glu Thr 50 55 60 Thr Tyr Tyr Thr Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 65 70 75 80 Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu 85 90 95 Asp Thr Ala Val Tyr Tyr Cys Ala Lys Gly Asp Tyr Tyr Cys Thr Thr 100 105 110 Tyr Glu Cys Gln His Tyr Tyr Gly Met Asp Tyr Trp Gly Lys Gly Thr 115 120 125 Leu Val Thr Val Ser Ser 130 <210> 78 <211> 134 <212> PRT <213> Artificial Sequence <400> 78 Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Arg Tyr 20 25 30 Trp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Glu Asp Ser Ser Ile Asn Thr Gly Gly Gly Thr Glu Thr 50 55 60 Thr Tyr Tyr Thr Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 65 70 75 80 Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu 85 90 95 Asp Thr Ala Val Tyr Tyr Cys Ala Lys Gly Asp Tyr Tyr Cys Thr Thr 100 105 110 Tyr Glu Cys Gln His Tyr Tyr Gly Met Asp Tyr Trp Gly Lys Gly Thr 115 120 125 Met Val Thr Val Ser Ser 130 <210> 79 <211> 134 <212> PRT <213> Artificial Sequence <400> 79 Glu Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Arg Tyr 20 25 30 Trp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Glu Asp Ser Ser Ile Asn Thr Gly Gly Gly Thr Glu Thr 50 55 60 Thr Tyr Tyr Thr Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 65 70 75 80 Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu 85 90 95 Asp Thr Ala Val Tyr Tyr Cys Ala Lys Gly Asp Tyr Tyr Cys Thr Thr 100 105 110 Tyr Glu Cys Gln His Tyr Tyr Gly Met Asp Tyr Trp Gly Lys Gly Thr 115 120 125 Pro Val Thr Val Ser Ser 130 <210> 80 <211> 134 <212> PRT <213> Artificial Sequence <400> 80 Gln Val Thr Leu Arg Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Arg Tyr 20 25 30 Trp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Glu Asp Ser Ser Ile Asn Thr Gly Gly Gly Thr Glu Thr 50 55 60 Thr Tyr Tyr Thr Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 65 70 75 80 Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu 85 90 95 Asp Thr Ala Val Tyr Tyr Cys Ala Lys Gly Asp Tyr Tyr Cys Thr Thr 100 105 110 Tyr Glu Cys Gln His Tyr Tyr Gly Met Asp Tyr Trp Gly Lys Gly Thr 115 120 125 Met Val Thr Val Ser Ser 130 <210> 81 <211> 134 <212> PRT <213> Artificial Sequence <400> 81 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 20 25 30 Trp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Asn Ile Lys Gln Asp Gly Ile Asn Thr Gly Gly Gly Thr Ser Glu 50 55 60 Lys Tyr Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 65 70 75 80 Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 85 90 95 Asp Thr Ala Val Tyr Tyr Cys Ala Lys Gly Asp Tyr Tyr Cys Thr Thr 100 105 110 Tyr Glu Cys Gln His Tyr Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr 115 120 125 Thr Val Thr Val Ser Ser 130 <210> 82 <211> 127 <212> PRT <213> Artificial Sequence <400> 82 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 20 25 30 Trp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Glu Asp Ser Ser Glu Thr Thr Tyr Tyr Thr Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Asp Tyr Tyr Cys Thr Thr Tyr Glu Cys Gln His Tyr Tyr 100 105 110 Gly Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 83 <211> 118 <212> PRT <213> Artificial Sequence <400> 83 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Ser Ile Phe Ser Ile Asn 20 25 30 Ala Met Asn Trp Tyr Arg Gln Ala Pro Gly Lys Gly Thr Glu Trp Val 35 40 45 Ala Gln Ile Thr Asp Glu Gly Ile Thr Asn Tyr Val Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn 85 90 95 Ala Phe Val Ile Thr Thr Thr Ser Glu Ile Tyr Trp Gly Gln Gly Thr 100 105 110 Thr Val Thr Val Ser Ser 115 <210> 84 <211> 128 <212> PRT <213> Artificial Sequence <400> 84 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 20 25 30 Trp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Glu Asp Ser Ser Thr Glu Thr Thr Tyr Tyr Thr Asp Ser 50 55 60 Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu 65 70 75 80 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Lys Gly Asp Tyr Tyr Cys Thr Thr Tyr Glu Cys Gln His Tyr 100 105 110 Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 85 <211> 129 <212> PRT <213> Artificial Sequence <400> 85 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 20 25 30 Trp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Glu Asp Ser Ser Ile Thr Glu Thr Thr Tyr Tyr Thr Asp 50 55 60 Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Ala Lys Gly Asp Tyr Tyr Cys Thr Thr Tyr Glu Cys Gln His 100 105 110 Tyr Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser 115 120 125 Ser <210> 86 <211> 129 <212> PRT <213> Artificial Sequence <400> 86 Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Gln Ala Ser Gly Phe Thr Phe Arg Arg Tyr 20 25 30 Trp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Asn Asp Gly Gly Gly Asp Asp Ser Thr Tyr Tyr Ala Asp 50 55 60 Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Val Lys Ser Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Ala Lys Gly Asp Tyr Tyr Cys Thr His Tyr Glu Cys Gln His 100 105 110 Tyr Tyr Gly Met Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 87 <211> 126 <212> PRT <213> Artificial Sequence <400> 87 Glu Val Gln Leu Val Gln Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Tyr 20 25 30 Trp Met Tyr Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Arg Thr Ser Gly Asp Thr Asp Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Lys Gly Asp Tyr Tyr Cys Thr Thr Tyr Glu Cys Gln His Tyr Tyr Gly 100 105 110 Met Asp Tyr Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 88 <211> 118 <212> PRT <213> Artificial Sequence <400> 88 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Ser Ile Phe Ser Ile Asn 20 25 30 Ala Met Asn Trp Tyr Arg Gln Ala Pro Gly Lys Gly Thr Glu Trp Val 35 40 45 Ala Gln Ile Thr Asp Glu Gly Ile Thr Asn Tyr Val Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn 85 90 95 Ala Phe Val Ile Thr Thr Thr Ser Glu Ile Tyr Trp Gly Gln Gly Thr 100 105 110 Thr Val Thr Val Ser Ser 115 <210> 89 <211> 107 <212> PRT <213> Artificial Sequence <400> 89 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ala Ile Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Ala Ser Val Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 90 <211> 107 <212> PRT <213> Artificial Sequence <400> 90 Val Ile Trp Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 <210> 91 <211> 107 <212> PRT <213> Artificial Sequence <400> 91 Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 92 <211> 107 <212> PRT <213> Artificial Sequence <400> 92 Asn Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly His Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Thr Leu Gln Arg Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Gly Gly Tyr Gly Thr Glu Phe Thr Leu Thr Ile Asp Ser Leu Gln Ser 65 70 75 80 Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Ser His Ser Leu Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Gln Gly Gly Asn Gln 100 105 <210> 93 <211> 107 <212> PRT <213> Artificial Sequence <400> 93 Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Thr Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Arg Asn 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 35 40 45 Tyr Thr Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Thr Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Ile Tyr His Cys Gln Gln Ser Tyr Arg Thr Pro Phe 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 94 <211> 107 <212> PRT <213> Artificial Sequence <400> 94 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ala Val Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln His Ile Ser Ser Trp 20 25 30 Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Pro Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Thr Ser Phe Pro Leu 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 95 <211> 107 <212> PRT <213> Artificial Sequence <400> 95 Ala Ile Arg Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser His Tyr 20 25 30 Leu Asn Trp Tyr Gln Trp Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Thr Arg Leu Gln Ser Gly Val Pro Pro Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Ile Tyr Phe Cys Gln Gln Ser Tyr Ser Ala Leu Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 <210> 96 <211> 107 <212> PRT <213> Artificial Sequence <400> 96 Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Thr Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 97 <211> 108 <212> PRT <213> Artificial Sequence <400> 97 Glu Thr Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 20 25 30 Tyr Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Thr Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Asp Thr Ser Pro 85 90 95 Arg Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 98 <211> 108 <212> PRT <213> Artificial Sequence <400> 98 Asn Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ser Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Ser Leu Ser Ile Pro Gln 85 90 95 Val Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 100 105 <210> 99 <211> 110 <212> PRT <213> Artificial Sequence <400> 99 Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Ala Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Val Pro Gly Thr Ala Pro Glu Leu Leu 35 40 45 Ile Tyr Asp Asn Tyr Arg Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 100 <211> 104 <212> PRT <213> Artificial Sequence <400> 100 Glu Leu Thr Gln Pro Ser Ala Val Ser Val Ser Leu Gly Gln Thr Val 1 5 10 15 Arg Ile Thr Cys Gln Gly Asp Arg Ile Glu Asn Tyr Tyr Thr Ser Trp 20 25 30 Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly Asn 35 40 45 Ala Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Ser Ser 50 55 60 Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu 65 70 75 80 Ala Asp Tyr Tyr Cys Gln Ser Gly Ser Ser Thr Glu Asn Ile Phe Gly 85 90 95 Gly Gly Thr Lys Leu Thr Val Leu 100 <210> 101 <211> 107 <212> PRT <213> Artificial Sequence <400> 101 Leu Pro Val Leu Thr Gln Pro Ser Ala Val Ser Val Ser Leu Gly Gln 1 5 10 15 Thr Ala Arg Ile Thr Cys Gln Gly Asp Arg Ile Glu Asn Tyr Tyr Thr 20 25 30 Ser Trp Phe Arg Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45 Gly Asn Ala Asn Arg Pro Ser Gly Val Pro Glu Arg Phe Ser Gly Ser 50 55 60 Ser Ser Gly Val Thr Ala Thr Leu Thr Ile Ser Gly Ala Gln Ala Glu 65 70 75 80 Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Gly Ser Ser Thr Glu Asn Ile 85 90 95 Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gln 100 105 <210> 102 <211> 107 <212> PRT <213> Artificial Sequence <400> 102 Leu Pro Val Leu Thr Gln Pro Ser Ala Val Ser Val Ser Leu Gly Gln 1 5 10 15 Thr Ala Arg Ile Thr Cys Gln Gly Asp Arg Ile Glu Asn Tyr Tyr Thr 20 25 30 Ser Trp Phe Arg Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45 Gly Asn Ala Asn Arg Pro Ser Gly Val Pro Glu Arg Phe Ser Gly Ser 50 55 60 Ser Ser Gly Val Thr Ala Thr Leu Thr Ile Ser Gly Ala Gln Ala Glu 65 70 75 80 Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Gly Ser Ser Thr Glu Asn Ile 85 90 95 Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gln 100 105 <210> 103 <211> 107 <212> PRT <213> Artificial Sequence <400> 103 Leu Pro Val Leu Thr Gln Pro Ser Ala Val Ser Val Ser Leu Gly Gln 1 5 10 15 Thr Ala Arg Ile Thr Cys Gln Gly Asp Arg Ile Glu Asn Tyr Tyr Thr 20 25 30 Ser Trp Phe Arg Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45 Gly Asn Ala Asn Arg Pro Ser Gly Val Pro Glu Arg Phe Ser Gly Ser 50 55 60 Ser Ser Gly Val Thr Ala Thr Leu Thr Ile Ser Gly Ala Gln Ala Glu 65 70 75 80 Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Gly Ser Ser Thr Glu Asn Ile 85 90 95 Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gln 100 105 <210> 104 <211> 110 <212> PRT <213> Artificial Sequence <400> 104 Asn Phe Met Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Lys Phe Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Asp Asn 20 25 30 Tyr Val Asn Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Ser Asn Arg Ala Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Ser Ser Gly Gly Thr Ala Thr Leu Thr Ile Ser Gly Ala Gln 65 70 75 80 Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Glu Ile Ser Gly 85 90 95 Tyr Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gln 100 105 110 <210> 105 <211> 112 <212> PRT <213> Artificial Sequence <400> 105 Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 1 5 10 15 Gln Pro Ala Ser Ile Ser Cys Thr Ser Ser Gln Ser Leu Val Tyr Arg 20 25 30 Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 35 40 45 Pro Arg Arg Leu Ile Tyr Lys Val Ser Asp Arg Asp Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 85 90 95 Thr His Trp Pro Ser Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 106 <211> 108 <212> PRT <213> Artificial Sequence <400> 106 Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Gln 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 107 <211> 116 <212> PRT <213> Artificial Sequence <400> 107 Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe Cys Asn 1 5 10 15 Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala Gln Asn 20 25 30 Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp Ile Tyr 35 40 45 Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp Phe Ser 50 55 60 Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala Ser Leu 65 70 75 80 Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr Thr Cys 85 90 95 Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu Leu Lys 100 105 110 Tyr Arg Val Val 115 <210> 108 <211> 220 <212> PRT <213> Artificial Sequence <400> 108 Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 1 5 10 15 Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 20 25 30 Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 35 40 45 Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 50 55 60 Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 65 70 75 80 Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 85 90 95 Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 100 105 110 Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 115 120 125 Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 130 135 140 Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 145 150 155 160 Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 165 170 175 Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 180 185 190 Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 195 200 205 Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 210 215 220