LISTADO DE SECUENCIAS <110> INTELLIA THERAPEUTICS, INC. <120> FORMULACIONES <130> 12793.0014-00304 <140> PCT/US2018/053559 <141> 2018-09-28 <150> 62/566,240 <151> 2017-09-29 <160> 84 <170> PatentIn versión 3.5 <210> 1 <211> 4140 <212> ADN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 1 atggacaaga agtacagcat cggactggac atcggaacaa acagcgtcgg atgggcagtc 60 atcacagacg aatacaaggt cccgagcaag aagttcaagg tcctgggaaa cacagacaga 120 cacagcatca agaagaacct gatcggagca ctgctgttcg acagcggaga aacagcagaa 180 gcaacaagac tgaagagaac agcaagaaga agatacacaa gaagaaagaa cagaatctgc 240 tacctgcagg aaatcttcag caacgaaatg gcaaaggtcg acgacagctt cttccacaga 300 ctggaagaaa gcttcctggt cgaagaagac aagaagcacg aaagacaccc gatcttcgga 360 aacatcgtcg acgaagtcgc ataccacgaa aagtacccga caatctacca cctgagaaag 420 aagctggtcg acagcacaga caaggcagac ctgagactga tctacctggc actggcacac 480 atgatcaagt tcagaggaca cttcctgatc gaaggagacc tgaacccgga caacagcgac 540 gtcgacaagc tgttcatcca gctggtccag acatacaacc agctgttcga agaaaacccg 600 atcaacgcaa gcggagtcga cgcaaaggca atcctgagcg caagactgag caagagcaga 660 agactggaaa acctgatcgc acagctgccg ggagaaaaga agaacggact gttcggaaac 720 ctgatcgcac tgagcctggg actgacaccg aacttcaaga gcaacttcga cctggcagaa 780 gacgcaaagc tgcagctgag caaggacaca tacgacgacg acctggacaa cctgctggca 840 cagatcggag accagtacgc agacctgttc ctggcagcaa agaacctgag cgacgcaatc 900 ctgctgagcg acatcctgag agtcaacaca gaaatcacaa aggcaccgct gagcgcaagc 960 atgatcaaga gatacgacga acaccaccag gacctgacac tgctgaaggc actggtcaga 1020 cagcagctgc cggaaaagta caaggaaatc ttcttcgacc agagcaagaa cggatacgca 1080 ggatacatcg acggaggagc aagccaggaa gaattctaca agttcatcaa gccgatcctg 1140 gaaaagatgg acggaacaga agaactgctg gtcaagctga acagagaaga cctgctgaga 1200 aagcagagaa cattcgacaa cggaagcatc ccgcaccaga tccacctggg agaactgcac 1260 gcaatcctga gaagacagga agacttctac ccgttcctga aggacaacag agaaaagatc 1320 gaaaagatcc tgacattcag aatcccgtac tacgtcggac cgctggcaag aggaaacagc 1380 agattcgcat ggatgacaag aaagagcgaa gaaacaatca caccgtggaa cttcgaagaa 1440 gtcgtcgaca agggagcaag cgcacagagc ttcatcgaaa gaatgacaaa cttcgacaag 1500 aacctgccga acgaaaaggt cctgccgaag cacagcctgc tgtacgaata cttcacagtc 1560 tacaacgaac tgacaaaggt caagtacgtc acagaaggaa tgagaaagcc ggcattcctg 1620 agcggagaac agaagaaggc aatcgtcgac ctgctgttca agacaaacag aaaggtcaca 1680 gtcaagcagc tgaaggaaga ctacttcaag aagatcgaat gcttcgacag cgtcgaaatc 1740 agcggagtcg aagacagatt caacgcaagc ctgggaacat accacgacct gctgaagatc 1800 atcaaggaca aggacttcct ggacaacgaa gaaaacgaag acatcctgga agacatcgtc 1860 ctgacactga cactgttcga agacagagaa atgatcgaag aaagactgaa gacatacgca 1920 cacctgttcg acgacaaggt catgaagcag ctgaagagaa gaagatacac aggatgggga 1980 agactgagca gaaagctgat caacggaatc agagacaagc agagcggaaa gacaatcctg 2040 gacttcctga agagcgacgg attcgcaaac agaaacttca tgcagctgat ccacgacgac 2100 agcctgacat tcaaggaaga catccagaag gcacaggtca gcggacaggg agacagcctg 2160 cacgaacaca tcgcaaacct ggcaggaagc ccggcaatca agaagggaat cctgcagaca 2220 gtcaaggtcg tcgacgaact ggtcaaggtc atgggaagac acaagccgga aaacatcgtc 2280 atcgaaatgg caagagaaaa ccagacaaca cagaagggac agaagaacag cagagaaaga 2340 atgaagagaa tcgaagaagg aatcaaggaa ctgggaagcc agatcctgaa ggaacacccg 2400 gtcgaaaaca cacagctgca gaacgaaaag ctgtacctgt actacctgca gaacggaaga 2460 gacatgtacg tcgaccagga actggacatc aacagactga gcgactacga cgtcgaccac 2520 atcgtcccgc agagcttcct gaaggacgac agcatcgaca acaaggtcct gacaagaagc 2580 gacaagaaca gaggaaagag cgacaacgtc ccgagcgaag aagtcgtcaa gaagatgaag 2640 aactactgga gacagctgct gaacgcaaag ctgatcacac agagaaagtt cgacaacctg 2700 acaaaggcag agagaggagg actgagcgaa ctggacaagg caggattcat caagagacag 2760 ctggtcgaaa caagacagat cacaaagcac gtcgcacaga tcctggacag cagaatgaac 2820 acaaagtacg acgaaaacga caagctgatc agagaagtca aggtcatcac actgaagagc 2880 aagctggtca gcgacttcag aaaggacttc cagttctaca aggtcagaga aatcaacaac 2940 taccaccacg cacacgacgc atacctgaac gcagtcgtcg gaacagcact gatcaagaag 3000 tacccgaagc tggaaagcga attcgtctac ggagactaca aggtctacga cgtcagaaag 3060 atgatcgcaa agagcgaaca ggaaatcgga aaggcaacag caaagtactt cttctacagc 3120 aacatcatga acttcttcaa gacagaaatc acactggcaa acggagaaat cagaaagaga 3180 ccgctgatcg aaacaaacgg agaaacagga gaaatcgtct gggacaaggg aagagacttc 3240 gcaacagtca gaaaggtcct gagcatgccg caggtcaaca tcgtcaagaa gacagaagtc 3300 cagacaggag gattcagcaa ggaaagcatc ctgccgaaga gaaacagcga caagctgatc 3360 gcaagaaaga aggactggga cccgaagaag tacggaggat tcgacagccc gacagtcgca 3420 tacagcgtcc tggtcgtcgc aaaggtcgaa aagggaaaga gcaagaagct gaagagcgtc 3480 aaggaactgc tgggaatcac aatcatggaa agaagcagct tcgaaaagaa cccgatcgac 3540 ttcctggaag caaagggata caaggaagtc aagaaggacc tgatcatcaa gctgccgaag 3600 tacagcctgt tcgaactgga aaacggaaga aagagaatgc tggcaagcgc aggagaactg 3660 cagaagggaa acgaactggc actgccgagc aagtacgtca acttcctgta cctggcaagc 3720 cactacgaaa agctgaaggg aagcccggaa gacaacgaac agaagcagct gttcgtcgaa 3780 cagcacaagc actacctgga cgaaatcatc gaacagatca gcgaattcag caagagagtc 3840 atcctggcag acgcaaacct ggacaaggtc ctgagcgcat acaacaagca cagagacaag 3900 ccgatcagag aacaggcaga aaacatcatc cacctgttca cactgacaaa cctgggagca 3960 ccggcagcat tcaagtactt cgacacaaca atcgacagaa agagatacac aagcacaaag 4020 gaagtcctgg acgcaacact gatccaccag agcatcacag gactgtacga aacaagaatc 4080 gacctgagcc agctgggagg agacggagga ggaagcccga agaagaagag aaaggtctag 4140 <210> 2 <211> 4143 <212> ADN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 2 atggataaga agtactcaat cgggctggat atcggaacta attccgtggg ttgggcagtg 60 atcacggatg aatacaaagt gccgtccaag aagttcaagg tcctggggaa caccgataga 120 cacagcatca agaaaaatct catcggagcc ctgctgtttg actccggcga aaccgcagaa 180 gcgacccggc tcaaacgtac cgcgaggcga cgctacaccc ggcggaagaa tcgcatctgc 240 tatctgcaag agatcttttc gaacgaaatg gcaaaggtcg acgacagctt cttccaccgc 300 ctggaagaat ctttcctggt ggaggaggac aagaagcatg aacggcatcc tatctttgga 360 aacatcgtcg acgaagtggc gtaccacgaa aagtacccga ccatctacca tctgcggaag 420 aagttggttg actcaactga caaggccgac ctcagattga tctacttggc cctcgcccat 480 atgatcaaat tccgcggaca cttcctgatc gaaggcgatc tgaaccctga taactccgac 540 gtggataagc ttttcattca actggtgcag acctacaacc aactgttcga agaaaaccca 600 atcaatgcta gcggcgtcga tgccaaggcc atcctgtccg cccggctgtc gaagtcgcgg 660 cgcctcgaaa acctgatcgc acagctgccg ggagagaaaa agaacggact tttcggcaac 720 ttgatcgctc tctcactggg actcactccc aatttcaagt ccaattttga cctggccgag 780 gacgcgaagc tgcaactctc aaaggacacc tacgacgacg acttggacaa tttgctggca 840 caaattggcg atcagtacgc ggatctgttc cttgccgcta agaacctttc ggacgcaatc 900 ttgctgtccg atatcctgcg cgtgaacacc gaaataacca aagcgccgct tagcgcctcg 960 atgattaagc ggtacgacga gcatcaccag gatctcacgc tgctcaaagc gctcgtgaga 1020 cagcaactgc ctgaaaagta caaggagatc ttcttcgacc agtccaagaa tgggtacgca 1080 gggtacatcg atggaggcgc tagccaggaa gagttctata agttcatcaa gccaatcctg 1140 gaaaagatgg acggaaccga agaactgctg gtcaagctga acagggagga tctgctccgg 1200 aaacagagaa cctttgacaa cggatccatt ccccaccaga tccatctggg tgagctgcac 1260 gccatcttgc ggcgccagga ggacttttac ccattcctca aggacaaccg ggaaaagatc 1320 gagaaaattc tgacgttccg catcccgtat tacgtgggcc cactggcgcg cggcaattcg 1380 cgcttcgcgt ggatgactag aaaatcagag gaaaccatca ctccttggaa tttcgaggaa 1440 gttgtggata agggagcttc ggcacaaagc ttcatcgaac gaatgaccaa cttcgacaag 1500 aatctcccaa acgagaaggt gcttcctaag cacagcctcc tttacgaata cttcactgtc 1560 tacaacgaac tgactaaagt gaaatacgtt actgaaggaa tgaggaagcc ggcctttctg 1620 tccggagaac agaagaaagc aattgtcgat ctgctgttca agaccaaccg caaggtgacc 1680 gtcaagcagc ttaaagagga ctacttcaag aagatcgagt gtttcgactc agtggaaatc 1740 agcggggtgg aggacagatt caacgcttcg ctgggaacct atcatgatct cctgaagatc 1800 atcaaggaca aggacttcct tgacaacgag gagaacgagg acatcctgga agatatcgtc 1860 ctgaccttga cccttttcga ggatcgcgag atgatcgagg agaggcttaa gacctacgct 1920 catctcttcg acgataaggt catgaaacaa ctcaagcgcc gccggtacac tggttggggc 1980 cgcctctccc gcaagctgat caacggtatt cgcgataaac agagcggtaa aactatcctg 2040 gatttcctca aatcggatgg cttcgctaat cgtaacttca tgcaattgat ccacgacgac 2100 agcctgacct ttaaggagga catccaaaaa gcacaagtgt ccggacaggg agactcactc 2160 catgaacaca tcgcgaatct ggccggttcg ccggcgatta agaagggaat tctgcaaact 2220 gtgaaggtgg tcgacgagct ggtgaaggtc atgggacggc acaaaccgga gaatatcgtg 2280 attgaaatgg cccgagaaaa ccagactacc cagaagggcc agaaaaactc ccgcgaaagg 2340 atgaagcgga tcgaagaagg aatcaaggag ctgggcagcc agatcctgaa agagcacccg 2400 gtggaaaaca cgcagctgca gaacgagaag ctctacctgt actatttgca aaatggacgg 2460 gacatgtacg tggaccaaga gctggacatc aatcggttgt ctgattacga cgtggaccac 2520 atcgttccac agtcctttct gaaggatgac tcgatcgata acaaggtgtt gactcgcagc 2580 gacaagaaca gagggaagtc agataatgtg ccatcggagg aggtcgtgaa gaagatgaag 2640 aattactggc ggcagctcct gaatgcgaag ctgattaccc agagaaagtt tgacaatctc 2700 actaaagccg agcgcggcgg actctcagag ctggataagg ctggattcat caaacggcag 2760 ctggtcgaga ctcggcagat taccaagcac gtggcgcaga tcttggactc ccgcatgaac 2820 actaaatacg acgagaacga taagctcatc cgggaagtga aggtgattac cctgaaaagc 2880 aaacttgtgt cggactttcg gaaggacttt cagttttaca aagtgagaga aatcaacaac 2940 taccatcacg cgcatgacgc atacctcaac gctgtggtcg gtaccgccct gatcaaaaag 3000 taccctaaac ttgaatcgga gtttgtgtac ggagactaca aggtctacga cgtgaggaag 3060 atgatagcca agtccgaaca ggaaatcggg aaagcaactg cgaaatactt cttttactca 3120 aacatcatga actttttcaa gactgaaatt acgctggcca atggagaaat caggaagagg 3180 ccactgatcg aaactaacgg agaaacgggc gaaatcgtgt gggacaaggg cagggacttc 3240 gcaactgttc gcaaagtgct ctctatgccg caagtcaata ttgtgaagaa aaccgaagtg 3300 caaaccggcg gattttcaaa ggaatcgatc ctcccaaaga gaaatagcga caagctcatt 3360 gcacgcaaga aagactggga cccgaagaag tacggaggat tcgattcgcc gactgtcgca 3420 tactccgtcc tcgtggtggc caaggtggag aagggaaaga gcaaaaagct caaatccgtc 3480 aaagagctgc tggggattac catcatggaa cgatcctcgt tcgagaagaa cccgattgat 3540 ttcctcgagg cgaagggtta caaggaggtg aagaaggatc tgatcatcaa actccccaag 3600 tactcactgt tcgaactgga aaatggtcgg aagcgcatgc tggcttcggc cggagaactc 3660 caaaaaggaa atgagctggc cttgcctagc aagtacgtca acttcctcta tcttgcttcg 3720 cactacgaaa aactcaaagg gtcaccggaa gataacgaac agaagcagct tttcgtggag 3780 cagcacaagc attatctgga tgaaatcatc gaacaaatct ccgagttttc aaagcgcgtg 3840 atcctcgccg acgccaacct cgacaaagtc ctgtcggcct acaataagca tagagataag 3900 ccgatcagag aacaggccga gaacattatc cacttgttca ccctgactaa cctgggagcc 3960 ccagccgcct tcaagtactt cgatactact atcgatcgca aaagatacac gtccaccaag 4020 gaagttctgg acgcgaccct gatccaccaa agcatcactg gactctacga aactaggatc 4080 gatctgtcgc agctgggtgg cgatggcggt ggatctccga aaaagaagag aaaggtgtaa 4140 tga 4143 <210> 3 <211> 1379 <212> PRT <213> Desconocido <220> <221> fuente <223> /nota="Descripción de desconocido: secuencia de Cas9" <400> 3 Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 1 5 10 15 Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 20 25 30 Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 35 40 45 Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 65 70 75 80 Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 100 105 110 His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 115 120 125 His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 130 135 140 Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 145 150 155 160 Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 165 170 175 Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 180 185 190 Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 195 200 205 Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 210 215 220 Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 225 230 235 240 Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 245 250 255 Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 260 265 270 Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 275 280 285 Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 290 295 300 Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 325 330 335 Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 340 345 350 Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 355 360 365 Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 370 375 380 Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 385 390 395 400 Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 405 410 415 Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 420 425 430 Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 450 455 460 Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 465 470 475 480 Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 485 490 495 Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 530 535 540 Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 545 550 555 560 Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 565 570 575 Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 580 585 590 Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 595 600 605 Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 610 615 620 Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 625 630 635 640 His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 645 650 655 Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 660 665 670 Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 675 680 685 Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 690 695 700 Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 705 710 715 720 His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 725 730 735 Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 740 745 750 Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 755 760 765 Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 770 775 780 Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 805 810 815 Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 820 825 830 Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 835 840 845 Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 850 855 860 Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 865 870 875 880 Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 885 890 895 Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 900 905 910 Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 915 920 925 Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 930 935 940 Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 945 950 955 960 Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 965 970 975 Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 980 985 990 Val Gly Thr Ala Leu Ile Lys Lys Tyr Pro Lys Leu Glu Ser Glu Phe 995 1000 1005 Val Tyr Gly Asp Tyr Lys Val Tyr Asp Val Arg Lys Met Ile Ala 1010 1015 1020 Lys Ser Glu Gln Glu Ile Gly Lys Ala Thr Ala Lys Tyr Phe Phe 1025 1030 1035 Tyr Ser Asn Ile Met Asn Phe Phe Lys Thr Glu Ile Thr Leu Ala 1040 1045 1050 Asn Gly Glu Ile Arg Lys Arg Pro Leu Ile Glu Thr Asn Gly Glu 1055 1060 1065 Thr Gly Glu Ile Val Trp Asp Lys Gly Arg Asp Phe Ala Thr Val 1070 1075 1080 Arg Lys Val Leu Ser Met Pro Gln Val Asn Ile Val Lys Lys Thr 1085 1090 1095 Glu Val Gln Thr Gly Gly Phe Ser Lys Glu Ser Ile Leu Pro Lys 1100 1105 1110 Arg Asn Ser Asp Lys Leu Ile Ala Arg Lys Lys Asp Trp Asp Pro 1115 1120 1125 Lys Lys Tyr Gly Gly Phe Asp Ser Pro Thr Val Ala Tyr Ser Val 1130 1135 1140 Leu Val Val Ala Lys Val Glu Lys Gly Lys Ser Lys Lys Leu Lys 1145 1150 1155 Ser Val Lys Glu Leu Leu Gly Ile Thr Ile Met Glu Arg Ser Ser 1160 1165 1170 Phe Glu Lys Asn Pro Ile Asp Phe Leu Glu Ala Lys Gly Tyr Lys 1175 1180 1185 Glu Val Lys Lys Asp Leu Ile Ile Lys Leu Pro Lys Tyr Ser Leu 1190 1195 1200 Phe Glu Leu Glu Asn Gly Arg Lys Arg Met Leu Ala Ser Ala Gly 1205 1210 1215 Glu Leu Gln Lys Gly Asn Glu Leu Ala Leu Pro Ser Lys Tyr Val 1220 1225 1230 Asn Phe Leu Tyr Leu Ala Ser His Tyr Glu Lys Leu Lys Gly Ser 1235 1240 1245 Pro Glu Asp Asn Glu Gln Lys Gln Leu Phe Val Glu Gln His Lys 1250 1255 1260 His Tyr Leu Asp Glu Ile Ile Glu Gln Ile Ser Glu Phe Ser Lys 1265 1270 1275 Arg Val Ile Leu Ala Asp Ala Asn Leu Asp Lys Val Leu Ser Ala 1280 1285 1290 Tyr Asn Lys His Arg Asp Lys Pro Ile Arg Glu Gln Ala Glu Asn 1295 1300 1305 Ile Ile His Leu Phe Thr Leu Thr Asn Leu Gly Ala Pro Ala Ala 1310 1315 1320 Phe Lys Tyr Phe Asp Thr Thr Ile Asp Arg Lys Arg Tyr Thr Ser 1325 1330 1335 Thr Lys Glu Val Leu Asp Ala Thr Leu Ile His Gln Ser Ile Thr 1340 1345 1350 Gly Leu Tyr Glu Thr Arg Ile Asp Leu Ser Gln Leu Gly Gly Asp 1355 1360 1365 Gly Gly Gly Ser Pro Lys Lys Lys Arg Lys Val 1370 1375 <210> 4 <211> 4140 <212> ARN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 4 auggacaaga aguacagcau cggacuggac aucggaacaa acagcgucgg augggcaguc 60 aucacagacg aauacaaggu cccgagcaag aaguucaagg uccugggaaa cacagacaga 120 cacagcauca agaagaaccu gaucggagca cugcuguucg acagcggaga aacagcagaa 180 gcaacaagac ugaagagaac agcaagaaga agauacacaa gaagaaagaa cagaaucugc 240 uaccugcagg aaaucuucag caacgaaaug gcaaaggucg acgacagcuu cuuccacaga 300 cuggaagaaa gcuuccuggu cgaagaagac aagaagcacg aaagacaccc gaucuucgga 360 aacaucgucg acgaagucgc auaccacgaa aaguacccga caaucuacca ccugagaaag 420 aagcuggucg acagcacaga caaggcagac cugagacuga ucuaccuggc acuggcacac 480 augaucaagu ucagaggaca cuuccugauc gaaggagacc ugaacccgga caacagcgac 540 gucgacaagc uguucaucca gcugguccag acauacaacc agcuguucga agaaaacccg 600 aucaacgcaa gcggagucga cgcaaaggca auccugagcg caagacugag caagagcaga 660 agacuggaaa accugaucgc acagcugccg ggagaaaaga agaacggacu guucggaaac 720 cugaucgcac ugagccuggg acugacaccg aacuucaaga gcaacuucga ccuggcagaa 780 gacgcaaagc ugcagcugag caaggacaca uacgacgacg accuggacaa ccugcuggca 840 cagaucggag accaguacgc agaccuguuc cuggcagcaa agaaccugag cgacgcaauc 900 cugcugagcg acauccugag agucaacaca gaaaucacaa aggcaccgcu gagcgcaagc 960 augaucaaga gauacgacga acaccaccag gaccugacac ugcugaaggc acuggucaga 1020 cagcagcugc cggaaaagua caaggaaauc uucuucgacc agagcaagaa cggauacgca 1080 ggauacaucg acggaggagc aagccaggaa gaauucuaca aguucaucaa gccgauccug 1140 gaaaagaugg acggaacaga agaacugcug gucaagcuga acagagaaga ccugcugaga 1200 aagcagagaa cauucgacaa cggaagcauc ccgcaccaga uccaccuggg agaacugcac 1260 gcaauccuga gaagacagga agacuucuac ccguuccuga aggacaacag agaaaagauc 1320 gaaaagaucc ugacauucag aaucccguac uacgucggac cgcuggcaag aggaaacagc 1380 agauucgcau ggaugacaag aaagagcgaa gaaacaauca caccguggaa cuucgaagaa 1440 gucgucgaca agggagcaag cgcacagagc uucaucgaaa gaaugacaaa cuucgacaag 1500 aaccugccga acgaaaaggu ccugccgaag cacagccugc uguacgaaua cuucacaguc 1560 uacaacgaac ugacaaaggu caaguacguc acagaaggaa ugagaaagcc ggcauuccug 1620 agcggagaac agaagaaggc aaucgucgac cugcuguuca agacaaacag aaaggucaca 1680 gucaagcagc ugaaggaaga cuacuucaag aagaucgaau gcuucgacag cgucgaaauc 1740 agcggagucg aagacagauu caacgcaagc cugggaacau accacgaccu gcugaagauc 1800 aucaaggaca aggacuuccu ggacaacgaa gaaaacgaag acauccugga agacaucguc 1860 cugacacuga cacuguucga agacagagaa augaucgaag aaagacugaa gacauacgca 1920 caccuguucg acgacaaggu caugaagcag cugaagagaa gaagauacac aggaugggga 1980 agacugagca gaaagcugau caacggaauc agagacaagc agagcggaaa gacaauccug 2040 gacuuccuga agagcgacgg auucgcaaac agaaacuuca ugcagcugau ccacgacgac 2100 agccugacau ucaaggaaga cauccagaag gcacagguca gcggacaggg agacagccug 2160 cacgaacaca ucgcaaaccu ggcaggaagc ccggcaauca agaagggaau ccugcagaca 2220 gucaaggucg ucgacgaacu ggucaagguc augggaagac acaagccgga aaacaucguc 2280 aucgaaaugg caagagaaaa ccagacaaca cagaagggac agaagaacag cagagaaaga 2340 augaagagaa ucgaagaagg aaucaaggaa cugggaagcc agauccugaa ggaacacccg 2400 gucgaaaaca cacagcugca gaacgaaaag cuguaccugu acuaccugca gaacggaaga 2460 gacauguacg ucgaccagga acuggacauc aacagacuga gcgacuacga cgucgaccac 2520 aucgucccgc agagcuuccu gaaggacgac agcaucgaca acaagguccu gacaagaagc 2580 gacaagaaca gaggaaagag cgacaacguc ccgagcgaag aagucgucaa gaagaugaag 2640 aacuacugga gacagcugcu gaacgcaaag cugaucacac agagaaaguu cgacaaccug 2700 acaaaggcag agagaggagg acugagcgaa cuggacaagg caggauucau caagagacag 2760 cuggucgaaa caagacagau cacaaagcac gucgcacaga uccuggacag cagaaugaac 2820 acaaaguacg acgaaaacga caagcugauc agagaaguca aggucaucac acugaagagc 2880 aagcugguca gcgacuucag aaaggacuuc caguucuaca aggucagaga aaucaacaac 2940 uaccaccacg cacacgacgc auaccugaac gcagucgucg gaacagcacu gaucaagaag 3000 uacccgaagc uggaaagcga auucgucuac ggagacuaca aggucuacga cgucagaaag 3060 augaucgcaa agagcgaaca ggaaaucgga aaggcaacag caaaguacuu cuucuacagc 3120 aacaucauga acuucuucaa gacagaaauc acacuggcaa acggagaaau cagaaagaga 3180 ccgcugaucg aaacaaacgg agaaacagga gaaaucgucu gggacaaggg aagagacuuc 3240 gcaacaguca gaaagguccu gagcaugccg caggucaaca ucgucaagaa gacagaaguc 3300 cagacaggag gauucagcaa ggaaagcauc cugccgaaga gaaacagcga caagcugauc 3360 gcaagaaaga aggacuggga cccgaagaag uacggaggau ucgacagccc gacagucgca 3420 uacagcgucc uggucgucgc aaaggucgaa aagggaaaga gcaagaagcu gaagagcguc 3480 aaggaacugc ugggaaucac aaucauggaa agaagcagcu ucgaaaagaa cccgaucgac 3540 uuccuggaag caaagggaua caaggaaguc aagaaggacc ugaucaucaa gcugccgaag 3600 uacagccugu ucgaacugga aaacggaaga aagagaaugc uggcaagcgc aggagaacug 3660 cagaagggaa acgaacuggc acugccgagc aaguacguca acuuccugua ccuggcaagc 3720 cacuacgaaa agcugaaggg aagcccggaa gacaacgaac agaagcagcu guucgucgaa 3780 cagcacaagc acuaccugga cgaaaucauc gaacagauca gcgaauucag caagagaguc 3840 auccuggcag acgcaaaccu ggacaagguc cugagcgcau acaacaagca cagagacaag 3900 ccgaucagag aacaggcaga aaacaucauc caccuguuca cacugacaaa ccugggagca 3960 ccggcagcau ucaaguacuu cgacacaaca aucgacagaa agagauacac aagcacaaag 4020 gaaguccugg acgcaacacu gauccaccag agcaucacag gacuguacga aacaagaauc 4080 gaccugagcc agcugggagg agacggagga ggaagcccga agaagaagag aaaggucuag 4140 <210> 5 <211> 4143 <212> ARN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 5 auggauaaga aguacucaau cgggcuggau aucggaacua auuccguggg uugggcagug 60 aucacggaug aauacaaagu gccguccaag aaguucaagg uccuggggaa caccgauaga 120 cacagcauca agaaaaaucu caucggagcc cugcuguuug acuccggcga aaccgcagaa 180 gcgacccggc ucaaacguac cgcgaggcga cgcuacaccc ggcggaagaa ucgcaucugc 240 uaucugcaag agaucuuuuc gaacgaaaug gcaaaggucg acgacagcuu cuuccaccgc 300 cuggaagaau cuuuccuggu ggaggaggac aagaagcaug aacggcaucc uaucuuugga 360 aacaucgucg acgaaguggc guaccacgaa aaguacccga ccaucuacca ucugcggaag 420 aaguugguug acucaacuga caaggccgac cucagauuga ucuacuuggc ccucgcccau 480 augaucaaau uccgcggaca cuuccugauc gaaggcgauc ugaacccuga uaacuccgac 540 guggauaagc uuuucauuca acuggugcag accuacaacc aacuguucga agaaaaccca 600 aucaaugcua gcggcgucga ugccaaggcc auccuguccg cccggcuguc gaagucgcgg 660 cgccucgaaa accugaucgc acagcugccg ggagagaaaa agaacggacu uuucggcaac 720 uugaucgcuc ucucacuggg acucacuccc aauuucaagu ccaauuuuga ccuggccgag 780 gacgcgaagc ugcaacucuc aaaggacacc uacgacgacg acuuggacaa uuugcuggca 840 caaauuggcg aucaguacgc ggaucuguuc cuugccgcua agaaccuuuc ggacgcaauc 900 uugcuguccg auauccugcg cgugaacacc gaaauaacca aagcgccgcu uagcgccucg 960 augauuaagc gguacgacga gcaucaccag gaucucacgc ugcucaaagc gcucgugaga 1020 cagcaacugc cugaaaagua caaggagauc uucuucgacc aguccaagaa uggguacgca 1080 ggguacaucg auggaggcgc uagccaggaa gaguucuaua aguucaucaa gccaauccug 1140 gaaaagaugg acggaaccga agaacugcug gucaagcuga acagggagga ucugcuccgg 1200 aaacagagaa ccuuugacaa cggauccauu ccccaccaga uccaucuggg ugagcugcac 1260 gccaucuugc ggcgccagga ggacuuuuac ccauuccuca aggacaaccg ggaaaagauc 1320 gagaaaauuc ugacguuccg caucccguau uacgugggcc cacuggcgcg cggcaauucg 1380 cgcuucgcgu ggaugacuag aaaaucagag gaaaccauca cuccuuggaa uuucgaggaa 1440 guuguggaua agggagcuuc ggcacaaagc uucaucgaac gaaugaccaa cuucgacaag 1500 aaucucccaa acgagaaggu gcuuccuaag cacagccucc uuuacgaaua cuucacuguc 1560 uacaacgaac ugacuaaagu gaaauacguu acugaaggaa ugaggaagcc ggccuuucug 1620 uccggagaac agaagaaagc aauugucgau cugcuguuca agaccaaccg caaggugacc 1680 gucaagcagc uuaaagagga cuacuucaag aagaucgagu guuucgacuc aguggaaauc 1740 agcggggugg aggacagauu caacgcuucg cugggaaccu aucaugaucu ccugaagauc 1800 aucaaggaca aggacuuccu ugacaacgag gagaacgagg acauccugga agauaucguc 1860 cugaccuuga cccuuuucga ggaucgcgag augaucgagg agaggcuuaa gaccuacgcu 1920 caucucuucg acgauaaggu caugaaacaa cucaagcgcc gccgguacac ugguuggggc 1980 cgccucuccc gcaagcugau caacgguauu cgcgauaaac agagcgguaa aacuauccug 2040 gauuuccuca aaucggaugg cuucgcuaau cguaacuuca ugcaauugau ccacgacgac 2100 agccugaccu uuaaggagga cauccaaaaa gcacaagugu ccggacaggg agacucacuc 2160 caugaacaca ucgcgaaucu ggccgguucg ccggcgauua agaagggaau ucugcaaacu 2220 gugaaggugg ucgacgagcu ggugaagguc augggacggc acaaaccgga gaauaucgug 2280 auugaaaugg cccgagaaaa ccagacuacc cagaagggcc agaaaaacuc ccgcgaaagg 2340 augaagcgga ucgaagaagg aaucaaggag cugggcagcc agauccugaa agagcacccg 2400 guggaaaaca cgcagcugca gaacgagaag cucuaccugu acuauuugca aaauggacgg 2460 gacauguacg uggaccaaga gcuggacauc aaucgguugu cugauuacga cguggaccac 2520 aucguuccac aguccuuucu gaaggaugac ucgaucgaua acaagguguu gacucgcagc 2580 gacaagaaca gagggaaguc agauaaugug ccaucggagg aggucgugaa gaagaugaag 2640 aauuacuggc ggcagcuccu gaaugcgaag cugauuaccc agagaaaguu ugacaaucuc 2700 acuaaagccg agcgcggcgg acucucagag cuggauaagg cuggauucau caaacggcag 2760 cuggucgaga cucggcagau uaccaagcac guggcgcaga ucuuggacuc ccgcaugaac 2820 acuaaauacg acgagaacga uaagcucauc cgggaaguga aggugauuac ccugaaaagc 2880 aaacuugugu cggacuuucg gaaggacuuu caguuuuaca aagugagaga aaucaacaac 2940 uaccaucacg cgcaugacgc auaccucaac gcuguggucg guaccgcccu gaucaaaaag 3000 uacccuaaac uugaaucgga guuuguguac ggagacuaca aggucuacga cgugaggaag 3060 augauagcca aguccgaaca ggaaaucggg aaagcaacug cgaaauacuu cuuuuacuca 3120 aacaucauga acuuuuucaa gacugaaauu acgcuggcca auggagaaau caggaagagg 3180 ccacugaucg aaacuaacgg agaaacgggc gaaaucgugu gggacaaggg cagggacuuc 3240 gcaacuguuc gcaaagugcu cucuaugccg caagucaaua uugugaagaa aaccgaagug 3300 caaaccggcg gauuuucaaa ggaaucgauc cucccaaaga gaaauagcga caagcucauu 3360 gcacgcaaga aagacuggga cccgaagaag uacggaggau ucgauucgcc gacugucgca 3420 uacuccgucc ucgugguggc caagguggag aagggaaaga gcaaaaagcu caaauccguc 3480 aaagagcugc uggggauuac caucauggaa cgauccucgu ucgagaagaa cccgauugau 3540 uuccucgagg cgaaggguua caaggaggug aagaaggauc ugaucaucaa acuccccaag 3600 uacucacugu ucgaacugga aaauggucgg aagcgcaugc uggcuucggc cggagaacuc 3660 caaaaaggaa augagcuggc cuugccuagc aaguacguca acuuccucua ucuugcuucg 3720 cacuacgaaa aacucaaagg gucaccggaa gauaacgaac agaagcagcu uuucguggag 3780 cagcacaagc auuaucugga ugaaaucauc gaacaaaucu ccgaguuuuc aaagcgcgug 3840 auccucgccg acgccaaccu cgacaaaguc cugucggccu acaauaagca uagagauaag 3900 ccgaucagag aacaggccga gaacauuauc cacuuguuca cccugacuaa ccugggagcc 3960 ccagccgccu ucaaguacuu cgauacuacu aucgaucgca aaagauacac guccaccaag 4020 gaaguucugg acgcgacccu gauccaccaa agcaucacug gacucuacga aacuaggauc 4080 gaucugucgc agcugggugg cgauggcggu ggaucuccga aaaagaagag aaagguguaa 4140 uga 4143 <210> 6 <211> 1379 <212> PRT <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polipéptido sintético" <400> 6 Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 1 5 10 15 Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 20 25 30 Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 35 40 45 Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 65 70 75 80 Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 100 105 110 His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 115 120 125 His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 130 135 140 Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 145 150 155 160 Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 165 170 175 Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 180 185 190 Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 195 200 205 Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 210 215 220 Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 225 230 235 240 Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 245 250 255 Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 260 265 270 Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 275 280 285 Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 290 295 300 Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 325 330 335 Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 340 345 350 Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 355 360 365 Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 370 375 380 Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 385 390 395 400 Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 405 410 415 Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 420 425 430 Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 450 455 460 Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 465 470 475 480 Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 485 490 495 Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 530 535 540 Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 545 550 555 560 Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 565 570 575 Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 580 585 590 Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 595 600 605 Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 610 615 620 Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 625 630 635 640 His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 645 650 655 Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 660 665 670 Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 675 680 685 Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 690 695 700 Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 705 710 715 720 His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 725 730 735 Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 740 745 750 Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 755 760 765 Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 770 775 780 Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 805 810 815 Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 820 825 830 Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 835 840 845 Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 850 855 860 Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 865 870 875 880 Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 885 890 895 Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 900 905 910 Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 915 920 925 Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 930 935 940 Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 945 950 955 960 Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 965 970 975 Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 980 985 990 Val Gly Thr Ala Leu Ile Lys Lys Tyr Pro Lys Leu Glu Ser Glu Phe 995 1000 1005 Val Tyr Gly Asp Tyr Lys Val Tyr Asp Val Arg Lys Met Ile Ala 1010 1015 1020 Lys Ser Glu Gln Glu Ile Gly Lys Ala Thr Ala Lys Tyr Phe Phe 1025 1030 1035 Tyr Ser Asn Ile Met Asn Phe Phe Lys Thr Glu Ile Thr Leu Ala 1040 1045 1050 Asn Gly Glu Ile Arg Lys Arg Pro Leu Ile Glu Thr Asn Gly Glu 1055 1060 1065 Thr Gly Glu Ile Val Trp Asp Lys Gly Arg Asp Phe Ala Thr Val 1070 1075 1080 Arg Lys Val Leu Ser Met Pro Gln Val Asn Ile Val Lys Lys Thr 1085 1090 1095 Glu Val Gln Thr Gly Gly Phe Ser Lys Glu Ser Ile Leu Pro Lys 1100 1105 1110 Arg Asn Ser Asp Lys Leu Ile Ala Arg Lys Lys Asp Trp Asp Pro 1115 1120 1125 Lys Lys Tyr Gly Gly Phe Asp Ser Pro Thr Val Ala Tyr Ser Val 1130 1135 1140 Leu Val Val Ala Lys Val Glu Lys Gly Lys Ser Lys Lys Leu Lys 1145 1150 1155 Ser Val Lys Glu Leu Leu Gly Ile Thr Ile Met Glu Arg Ser Ser 1160 1165 1170 Phe Glu Lys Asn Pro Ile Asp Phe Leu Glu Ala Lys Gly Tyr Lys 1175 1180 1185 Glu Val Lys Lys Asp Leu Ile Ile Lys Leu Pro Lys Tyr Ser Leu 1190 1195 1200 Phe Glu Leu Glu Asn Gly Arg Lys Arg Met Leu Ala Ser Ala Gly 1205 1210 1215 Glu Leu Gln Lys Gly Asn Glu Leu Ala Leu Pro Ser Lys Tyr Val 1220 1225 1230 Asn Phe Leu Tyr Leu Ala Ser His Tyr Glu Lys Leu Lys Gly Ser 1235 1240 1245 Pro Glu Asp Asn Glu Gln Lys Gln Leu Phe Val Glu Gln His Lys 1250 1255 1260 His Tyr Leu Asp Glu Ile Ile Glu Gln Ile Ser Glu Phe Ser Lys 1265 1270 1275 Arg Val Ile Leu Ala Asp Ala Asn Leu Asp Lys Val Leu Ser Ala 1280 1285 1290 Tyr Asn Lys His Arg Asp Lys Pro Ile Arg Glu Gln Ala Glu Asn 1295 1300 1305 Ile Ile His Leu Phe Thr Leu Thr Asn Leu Gly Ala Pro Ala Ala 1310 1315 1320 Phe Lys Tyr Phe Asp Thr Thr Ile Asp Arg Lys Arg Tyr Thr Ser 1325 1330 1335 Thr Lys Glu Val Leu Asp Ala Thr Leu Ile His Gln Ser Ile Thr 1340 1345 1350 Gly Leu Tyr Glu Thr Arg Ile Asp Leu Ser Gln Leu Gly Gly Asp 1355 1360 1365 Gly Gly Gly Ser Pro Lys Lys Lys Arg Lys Val 1370 1375 <210> 7 <211> 4140 <212> ARN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 7 auggacaaga aguacagcau cggacuggca aucggaacaa acagcgucgg augggcaguc 60 aucacagacg aauacaaggu cccgagcaag aaguucaagg uccugggaaa cacagacaga 120 cacagcauca agaagaaccu gaucggagca cugcuguucg acagcggaga aacagcagaa 180 gcaacaagac ugaagagaac agcaagaaga agauacacaa gaagaaagaa cagaaucugc 240 uaccugcagg aaaucuucag caacgaaaug gcaaaggucg acgacagcuu cuuccacaga 300 cuggaagaaa gcuuccuggu cgaagaagac aagaagcacg aaagacaccc gaucuucgga 360 aacaucgucg acgaagucgc auaccacgaa aaguacccga caaucuacca ccugagaaag 420 aagcuggucg acagcacaga caaggcagac cugagacuga ucuaccuggc acuggcacac 480 augaucaagu ucagaggaca cuuccugauc gaaggagacc ugaacccgga caacagcgac 540 gucgacaagc uguucaucca gcugguccag acauacaacc agcuguucga agaaaacccg 600 aucaacgcaa gcggagucga cgcaaaggca auccugagcg caagacugag caagagcaga 660 agacuggaaa accugaucgc acagcugccg ggagaaaaga agaacggacu guucggaaac 720 cugaucgcac ugagccuggg acugacaccg aacuucaaga gcaacuucga ccuggcagaa 780 gacgcaaagc ugcagcugag caaggacaca uacgacgacg accuggacaa ccugcuggca 840 cagaucggag accaguacgc agaccuguuc cuggcagcaa agaaccugag cgacgcaauc 900 cugcugagcg acauccugag agucaacaca gaaaucacaa aggcaccgcu gagcgcaagc 960 augaucaaga gauacgacga acaccaccag gaccugacac ugcugaaggc acuggucaga 1020 cagcagcugc cggaaaagua caaggaaauc uucuucgacc agagcaagaa cggauacgca 1080 ggauacaucg acggaggagc aagccaggaa gaauucuaca aguucaucaa gccgauccug 1140 gaaaagaugg acggaacaga agaacugcug gucaagcuga acagagaaga ccugcugaga 1200 aagcagagaa cauucgacaa cggaagcauc ccgcaccaga uccaccuggg agaacugcac 1260 gcaauccuga gaagacagga agacuucuac ccguuccuga aggacaacag agaaaagauc 1320 gaaaagaucc ugacauucag aaucccguac uacgucggac cgcuggcaag aggaaacagc 1380 agauucgcau ggaugacaag aaagagcgaa gaaacaauca caccguggaa cuucgaagaa 1440 gucgucgaca agggagcaag cgcacagagc uucaucgaaa gaaugacaaa cuucgacaag 1500 aaccugccga acgaaaaggu ccugccgaag cacagccugc uguacgaaua cuucacaguc 1560 uacaacgaac ugacaaaggu caaguacguc acagaaggaa ugagaaagcc ggcauuccug 1620 agcggagaac agaagaaggc aaucgucgac cugcuguuca agacaaacag aaaggucaca 1680 gucaagcagc ugaaggaaga cuacuucaag aagaucgaau gcuucgacag cgucgaaauc 1740 agcggagucg aagacagauu caacgcaagc cugggaacau accacgaccu gcugaagauc 1800 aucaaggaca aggacuuccu ggacaacgaa gaaaacgaag acauccugga agacaucguc 1860 cugacacuga cacuguucga agacagagaa augaucgaag aaagacugaa gacauacgca 1920 caccuguucg acgacaaggu caugaagcag cugaagagaa gaagauacac aggaugggga 1980 agacugagca gaaagcugau caacggaauc agagacaagc agagcggaaa gacaauccug 2040 gacuuccuga agagcgacgg auucgcaaac agaaacuuca ugcagcugau ccacgacgac 2100 agccugacau ucaaggaaga cauccagaag gcacagguca gcggacaggg agacagccug 2160 cacgaacaca ucgcaaaccu ggcaggaagc ccggcaauca agaagggaau ccugcagaca 2220 gucaaggucg ucgacgaacu ggucaagguc augggaagac acaagccgga aaacaucguc 2280 aucgaaaugg caagagaaaa ccagacaaca cagaagggac agaagaacag cagagaaaga 2340 augaagagaa ucgaagaagg aaucaaggaa cugggaagcc agauccugaa ggaacacccg 2400 gucgaaaaca cacagcugca gaacgaaaag cuguaccugu acuaccugca gaacggaaga 2460 gacauguacg ucgaccagga acuggacauc aacagacuga gcgacuacga cgucgaccac 2520 aucgucccgc agagcuuccu gaaggacgac agcaucgaca acaagguccu gacaagaagc 2580 gacaagaaca gaggaaagag cgacaacguc ccgagcgaag aagucgucaa gaagaugaag 2640 aacuacugga gacagcugcu gaacgcaaag cugaucacac agagaaaguu cgacaaccug 2700 acaaaggcag agagaggagg acugagcgaa cuggacaagg caggauucau caagagacag 2760 cuggucgaaa caagacagau cacaaagcac gucgcacaga uccuggacag cagaaugaac 2820 acaaaguacg acgaaaacga caagcugauc agagaaguca aggucaucac acugaagagc 2880 aagcugguca gcgacuucag aaaggacuuc caguucuaca aggucagaga aaucaacaac 2940 uaccaccacg cacacgacgc auaccugaac gcagucgucg gaacagcacu gaucaagaag 3000 uacccgaagc uggaaagcga auucgucuac ggagacuaca aggucuacga cgucagaaag 3060 augaucgcaa agagcgaaca ggaaaucgga aaggcaacag caaaguacuu cuucuacagc 3120 aacaucauga acuucuucaa gacagaaauc acacuggcaa acggagaaau cagaaagaga 3180 ccgcugaucg aaacaaacgg agaaacagga gaaaucgucu gggacaaggg aagagacuuc 3240 gcaacaguca gaaagguccu gagcaugccg caggucaaca ucgucaagaa gacagaaguc 3300 cagacaggag gauucagcaa ggaaagcauc cugccgaaga gaaacagcga caagcugauc 3360 gcaagaaaga aggacuggga cccgaagaag uacggaggau ucgacagccc gacagucgca 3420 uacagcgucc uggucgucgc aaaggucgaa aagggaaaga gcaagaagcu gaagagcguc 3480 aaggaacugc ugggaaucac aaucauggaa agaagcagcu ucgaaaagaa cccgaucgac 3540 uuccuggaag caaagggaua caaggaaguc aagaaggacc ugaucaucaa gcugccgaag 3600 uacagccugu ucgaacugga aaacggaaga aagagaaugc uggcaagcgc aggagaacug 3660 cagaagggaa acgaacuggc acugccgagc aaguacguca acuuccugua ccuggcaagc 3720 cacuacgaaa agcugaaggg aagcccggaa gacaacgaac agaagcagcu guucgucgaa 3780 cagcacaagc acuaccugga cgaaaucauc gaacagauca gcgaauucag caagagaguc 3840 auccuggcag acgcaaaccu ggacaagguc cugagcgcau acaacaagca cagagacaag 3900 ccgaucagag aacaggcaga aaacaucauc caccuguuca cacugacaaa ccugggagca 3960 ccggcagcau ucaaguacuu cgacacaaca aucgacagaa agagauacac aagcacaaag 4020 gaaguccugg acgcaacacu gauccaccag agcaucacag gacuguacga aacaagaauc 4080 gaccugagcc agcugggagg agacggagga ggaagcccga agaagaagag aaaggucuag 4140 <210> 8 <211> 1379 <212> PRT <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polipéptido sintético" <400> 8 Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 1 5 10 15 Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 20 25 30 Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 35 40 45 Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 65 70 75 80 Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 100 105 110 His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 115 120 125 His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 130 135 140 Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 145 150 155 160 Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 165 170 175 Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 180 185 190 Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 195 200 205 Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 210 215 220 Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 225 230 235 240 Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 245 250 255 Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 260 265 270 Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 275 280 285 Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 290 295 300 Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 325 330 335 Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 340 345 350 Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 355 360 365 Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 370 375 380 Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 385 390 395 400 Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 405 410 415 Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 420 425 430 Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 450 455 460 Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 465 470 475 480 Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 485 490 495 Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 530 535 540 Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 545 550 555 560 Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 565 570 575 Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 580 585 590 Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 595 600 605 Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 610 615 620 Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 625 630 635 640 His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 645 650 655 Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 660 665 670 Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 675 680 685 Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 690 695 700 Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 705 710 715 720 His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 725 730 735 Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 740 745 750 Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 755 760 765 Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 770 775 780 Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 805 810 815 Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 820 825 830 Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys 835 840 845 Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 850 855 860 Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 865 870 875 880 Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 885 890 895 Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 900 905 910 Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 915 920 925 Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 930 935 940 Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 945 950 955 960 Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 965 970 975 Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 980 985 990 Val Gly Thr Ala Leu Ile Lys Lys Tyr Pro Lys Leu Glu Ser Glu Phe 995 1000 1005 Val Tyr Gly Asp Tyr Lys Val Tyr Asp Val Arg Lys Met Ile Ala 1010 1015 1020 Lys Ser Glu Gln Glu Ile Gly Lys Ala Thr Ala Lys Tyr Phe Phe 1025 1030 1035 Tyr Ser Asn Ile Met Asn Phe Phe Lys Thr Glu Ile Thr Leu Ala 1040 1045 1050 Asn Gly Glu Ile Arg Lys Arg Pro Leu Ile Glu Thr Asn Gly Glu 1055 1060 1065 Thr Gly Glu Ile Val Trp Asp Lys Gly Arg Asp Phe Ala Thr Val 1070 1075 1080 Arg Lys Val Leu Ser Met Pro Gln Val Asn Ile Val Lys Lys Thr 1085 1090 1095 Glu Val Gln Thr Gly Gly Phe Ser Lys Glu Ser Ile Leu Pro Lys 1100 1105 1110 Arg Asn Ser Asp Lys Leu Ile Ala Arg Lys Lys Asp Trp Asp Pro 1115 1120 1125 Lys Lys Tyr Gly Gly Phe Asp Ser Pro Thr Val Ala Tyr Ser Val 1130 1135 1140 Leu Val Val Ala Lys Val Glu Lys Gly Lys Ser Lys Lys Leu Lys 1145 1150 1155 Ser Val Lys Glu Leu Leu Gly Ile Thr Ile Met Glu Arg Ser Ser 1160 1165 1170 Phe Glu Lys Asn Pro Ile Asp Phe Leu Glu Ala Lys Gly Tyr Lys 1175 1180 1185 Glu Val Lys Lys Asp Leu Ile Ile Lys Leu Pro Lys Tyr Ser Leu 1190 1195 1200 Phe Glu Leu Glu Asn Gly Arg Lys Arg Met Leu Ala Ser Ala Gly 1205 1210 1215 Glu Leu Gln Lys Gly Asn Glu Leu Ala Leu Pro Ser Lys Tyr Val 1220 1225 1230 Asn Phe Leu Tyr Leu Ala Ser His Tyr Glu Lys Leu Lys Gly Ser 1235 1240 1245 Pro Glu Asp Asn Glu Gln Lys Gln Leu Phe Val Glu Gln His Lys 1250 1255 1260 His Tyr Leu Asp Glu Ile Ile Glu Gln Ile Ser Glu Phe Ser Lys 1265 1270 1275 Arg Val Ile Leu Ala Asp Ala Asn Leu Asp Lys Val Leu Ser Ala 1280 1285 1290 Tyr Asn Lys His Arg Asp Lys Pro Ile Arg Glu Gln Ala Glu Asn 1295 1300 1305 Ile Ile His Leu Phe Thr Leu Thr Asn Leu Gly Ala Pro Ala Ala 1310 1315 1320 Phe Lys Tyr Phe Asp Thr Thr Ile Asp Arg Lys Arg Tyr Thr Ser 1325 1330 1335 Thr Lys Glu Val Leu Asp Ala Thr Leu Ile His Gln Ser Ile Thr 1340 1345 1350 Gly Leu Tyr Glu Thr Arg Ile Asp Leu Ser Gln Leu Gly Gly Asp 1355 1360 1365 Gly Gly Gly Ser Pro Lys Lys Lys Arg Lys Val 1370 1375 <210> 9 <211> 4140 <212> ARN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 9 auggacaaga aguacagcau cggacuggca aucggaacaa acagcgucgg augggcaguc 60 aucacagacg aauacaaggu cccgagcaag aaguucaagg uccugggaaa cacagacaga 120 cacagcauca agaagaaccu gaucggagca cugcuguucg acagcggaga aacagcagaa 180 gcaacaagac ugaagagaac agcaagaaga agauacacaa gaagaaagaa cagaaucugc 240 uaccugcagg aaaucuucag caacgaaaug gcaaaggucg acgacagcuu cuuccacaga 300 cuggaagaaa gcuuccuggu cgaagaagac aagaagcacg aaagacaccc gaucuucgga 360 aacaucgucg acgaagucgc auaccacgaa aaguacccga caaucuacca ccugagaaag 420 aagcuggucg acagcacaga caaggcagac cugagacuga ucuaccuggc acuggcacac 480 augaucaagu ucagaggaca cuuccugauc gaaggagacc ugaacccgga caacagcgac 540 gucgacaagc uguucaucca gcugguccag acauacaacc agcuguucga agaaaacccg 600 aucaacgcaa gcggagucga cgcaaaggca auccugagcg caagacugag caagagcaga 660 agacuggaaa accugaucgc acagcugccg ggagaaaaga agaacggacu guucggaaac 720 cugaucgcac ugagccuggg acugacaccg aacuucaaga gcaacuucga ccuggcagaa 780 gacgcaaagc ugcagcugag caaggacaca uacgacgacg accuggacaa ccugcuggca 840 cagaucggag accaguacgc agaccuguuc cuggcagcaa agaaccugag cgacgcaauc 900 cugcugagcg acauccugag agucaacaca gaaaucacaa aggcaccgcu gagcgcaagc 960 augaucaaga gauacgacga acaccaccag gaccugacac ugcugaaggc acuggucaga 1020 cagcagcugc cggaaaagua caaggaaauc uucuucgacc agagcaagaa cggauacgca 1080 ggauacaucg acggaggagc aagccaggaa gaauucuaca aguucaucaa gccgauccug 1140 gaaaagaugg acggaacaga agaacugcug gucaagcuga acagagaaga ccugcugaga 1200 aagcagagaa cauucgacaa cggaagcauc ccgcaccaga uccaccuggg agaacugcac 1260 gcaauccuga gaagacagga agacuucuac ccguuccuga aggacaacag agaaaagauc 1320 gaaaagaucc ugacauucag aaucccguac uacgucggac cgcuggcaag aggaaacagc 1380 agauucgcau ggaugacaag aaagagcgaa gaaacaauca caccguggaa cuucgaagaa 1440 gucgucgaca agggagcaag cgcacagagc uucaucgaaa gaaugacaaa cuucgacaag 1500 aaccugccga acgaaaaggu ccugccgaag cacagccugc uguacgaaua cuucacaguc 1560 uacaacgaac ugacaaaggu caaguacguc acagaaggaa ugagaaagcc ggcauuccug 1620 agcggagaac agaagaaggc aaucgucgac cugcuguuca agacaaacag aaaggucaca 1680 gucaagcagc ugaaggaaga cuacuucaag aagaucgaau gcuucgacag cgucgaaauc 1740 agcggagucg aagacagauu caacgcaagc cugggaacau accacgaccu gcugaagauc 1800 aucaaggaca aggacuuccu ggacaacgaa gaaaacgaag acauccugga agacaucguc 1860 cugacacuga cacuguucga agacagagaa augaucgaag aaagacugaa gacauacgca 1920 caccuguucg acgacaaggu caugaagcag cugaagagaa gaagauacac aggaugggga 1980 agacugagca gaaagcugau caacggaauc agagacaagc agagcggaaa gacaauccug 2040 gacuuccuga agagcgacgg auucgcaaac agaaacuuca ugcagcugau ccacgacgac 2100 agccugacau ucaaggaaga cauccagaag gcacagguca gcggacaggg agacagccug 2160 cacgaacaca ucgcaaaccu ggcaggaagc ccggcaauca agaagggaau ccugcagaca 2220 gucaaggucg ucgacgaacu ggucaagguc augggaagac acaagccgga aaacaucguc 2280 aucgaaaugg caagagaaaa ccagacaaca cagaagggac agaagaacag cagagaaaga 2340 augaagagaa ucgaagaagg aaucaaggaa cugggaagcc agauccugaa ggaacacccg 2400 gucgaaaaca cacagcugca gaacgaaaag cuguaccugu acuaccugca gaacggaaga 2460 gacauguacg ucgaccagga acuggacauc aacagacuga gcgacuacga cgucgacgca 2520 aucgucccgc agagcuuccu gaaggacgac agcaucgaca acaagguccu gacaagaagc 2580 gacaagaaca gaggaaagag cgacaacguc ccgagcgaag aagucgucaa gaagaugaag 2640 aacuacugga gacagcugcu gaacgcaaag cugaucacac agagaaaguu cgacaaccug 2700 acaaaggcag agagaggagg acugagcgaa cuggacaagg caggauucau caagagacag 2760 cuggucgaaa caagacagau cacaaagcac gucgcacaga uccuggacag cagaaugaac 2820 acaaaguacg acgaaaacga caagcugauc agagaaguca aggucaucac acugaagagc 2880 aagcugguca gcgacuucag aaaggacuuc caguucuaca aggucagaga aaucaacaac 2940 uaccaccacg cacacgacgc auaccugaac gcagucgucg gaacagcacu gaucaagaag 3000 uacccgaagc uggaaagcga auucgucuac ggagacuaca aggucuacga cgucagaaag 3060 augaucgcaa agagcgaaca ggaaaucgga aaggcaacag caaaguacuu cuucuacagc 3120 aacaucauga acuucuucaa gacagaaauc acacuggcaa acggagaaau cagaaagaga 3180 ccgcugaucg aaacaaacgg agaaacagga gaaaucgucu gggacaaggg aagagacuuc 3240 gcaacaguca gaaagguccu gagcaugccg caggucaaca ucgucaagaa gacagaaguc 3300 cagacaggag gauucagcaa ggaaagcauc cugccgaaga gaaacagcga caagcugauc 3360 gcaagaaaga aggacuggga cccgaagaag uacggaggau ucgacagccc gacagucgca 3420 uacagcgucc uggucgucgc aaaggucgaa aagggaaaga gcaagaagcu gaagagcguc 3480 aaggaacugc ugggaaucac aaucauggaa agaagcagcu ucgaaaagaa cccgaucgac 3540 uuccuggaag caaagggaua caaggaaguc aagaaggacc ugaucaucaa gcugccgaag 3600 uacagccugu ucgaacugga aaacggaaga aagagaaugc uggcaagcgc aggagaacug 3660 cagaagggaa acgaacuggc acugccgagc aaguacguca acuuccugua ccuggcaagc 3720 cacuacgaaa agcugaaggg aagcccggaa gacaacgaac agaagcagcu guucgucgaa 3780 cagcacaagc acuaccugga cgaaaucauc gaacagauca gcgaauucag caagagaguc 3840 auccuggcag acgcaaaccu ggacaagguc cugagcgcau acaacaagca cagagacaag 3900 ccgaucagag aacaggcaga aaacaucauc caccuguuca cacugacaaa ccugggagca 3960 ccggcagcau ucaaguacuu cgacacaaca aucgacagaa agagauacac aagcacaaag 4020 gaaguccugg acgcaacacu gauccaccag agcaucacag gacuguacga aacaagaauc 4080 gaccugagcc agcugggagg agacggagga ggaagcccga agaagaagag aaaggucuag 4140 <210> 10 <211> 4134 <212> ARN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 10 gacaagaagu acagcaucgg acuggacauc ggaacaaaca gcgucggaug ggcagucauc 60 acagacgaau acaagguccc gagcaagaag uucaaggucc ugggaaacac agacagacac 120 agcaucaaga agaaccugau cggagcacug cuguucgaca gcggagaaac agcagaagca 180 acaagacuga agagaacagc aagaagaaga uacacaagaa gaaagaacag aaucugcuac 240 cugcaggaaa ucuucagcaa cgaaauggca aaggucgacg acagcuucuu ccacagacug 300 gaagaaagcu uccuggucga agaagacaag aagcacgaaa gacacccgau cuucggaaac 360 aucgucgacg aagucgcaua ccacgaaaag uacccgacaa ucuaccaccu gagaaagaag 420 cuggucgaca gcacagacaa ggcagaccug agacugaucu accuggcacu ggcacacaug 480 aucaaguuca gaggacacuu ccugaucgaa ggagaccuga acccggacaa cagcgacguc 540 gacaagcugu ucauccagcu gguccagaca uacaaccagc uguucgaaga aaacccgauc 600 aacgcaagcg gagucgacgc aaaggcaauc cugagcgcaa gacugagcaa gagcagaaga 660 cuggaaaacc ugaucgcaca gcugccggga gaaaagaaga acggacuguu cggaaaccug 720 aucgcacuga gccugggacu gacaccgaac uucaagagca acuucgaccu ggcagaagac 780 gcaaagcugc agcugagcaa ggacacauac gacgacgacc uggacaaccu gcuggcacag 840 aucggagacc aguacgcaga ccuguuccug gcagcaaaga accugagcga cgcaauccug 900 cugagcgaca uccugagagu caacacagaa aucacaaagg caccgcugag cgcaagcaug 960 aucaagagau acgacgaaca ccaccaggac cugacacugc ugaaggcacu ggucagacag 1020 cagcugccgg aaaaguacaa ggaaaucuuc uucgaccaga gcaagaacgg auacgcagga 1080 uacaucgacg gaggagcaag ccaggaagaa uucuacaagu ucaucaagcc gauccuggaa 1140 aagauggacg gaacagaaga acugcugguc aagcugaaca gagaagaccu gcugagaaag 1200 cagagaacau ucgacaacgg aagcaucccg caccagaucc accugggaga acugcacgca 1260 auccugagaa gacaggaaga cuucuacccg uuccugaagg acaacagaga aaagaucgaa 1320 aagauccuga cauucagaau cccguacuac gucggaccgc uggcaagagg aaacagcaga 1380 uucgcaugga ugacaagaaa gagcgaagaa acaaucacac cguggaacuu cgaagaaguc 1440 gucgacaagg gagcaagcgc acagagcuuc aucgaaagaa ugacaaacuu cgacaagaac 1500 cugccgaacg aaaagguccu gccgaagcac agccugcugu acgaauacuu cacagucuac 1560 aacgaacuga caaaggucaa guacgucaca gaaggaauga gaaagccggc auuccugagc 1620 ggagaacaga agaaggcaau cgucgaccug cuguucaaga caaacagaaa ggucacaguc 1680 aagcagcuga aggaagacua cuucaagaag aucgaaugcu ucgacagcgu cgaaaucagc 1740 ggagucgaag acagauucaa cgcaagccug ggaacauacc acgaccugcu gaagaucauc 1800 aaggacaagg acuuccugga caacgaagaa aacgaagaca uccuggaaga caucguccug 1860 acacugacac uguucgaaga cagagaaaug aucgaagaaa gacugaagac auacgcacac 1920 cuguucgacg acaaggucau gaagcagcug aagagaagaa gauacacagg auggggaaga 1980 cugagcagaa agcugaucaa cggaaucaga gacaagcaga gcggaaagac aauccuggac 2040 uuccugaaga gcgacggauu cgcaaacaga aacuucaugc agcugaucca cgacgacagc 2100 cugacauuca aggaagacau ccagaaggca caggucagcg gacagggaga cagccugcac 2160 gaacacaucg caaaccuggc aggaagcccg gcaaucaaga agggaauccu gcagacaguc 2220 aaggucgucg acgaacuggu caaggucaug ggaagacaca agccggaaaa caucgucauc 2280 gaaauggcaa gagaaaacca gacaacacag aagggacaga agaacagcag agaaagaaug 2340 aagagaaucg aagaaggaau caaggaacug ggaagccaga uccugaagga acacccgguc 2400 gaaaacacac agcugcagaa cgaaaagcug uaccuguacu accugcagaa cggaagagac 2460 auguacgucg accaggaacu ggacaucaac agacugagcg acuacgacgu cgaccacauc 2520 gucccgcaga gcuuccugaa ggacgacagc aucgacaaca agguccugac aagaagcgac 2580 aagaacagag gaaagagcga caacgucccg agcgaagaag ucgucaagaa gaugaagaac 2640 uacuggagac agcugcugaa cgcaaagcug aucacacaga gaaaguucga caaccugaca 2700 aaggcagaga gaggaggacu gagcgaacug gacaaggcag gauucaucaa gagacagcug 2760 gucgaaacaa gacagaucac aaagcacguc gcacagaucc uggacagcag aaugaacaca 2820 aaguacgacg aaaacgacaa gcugaucaga gaagucaagg ucaucacacu gaagagcaag 2880 cuggucagcg acuucagaaa ggacuuccag uucuacaagg ucagagaaau caacaacuac 2940 caccacgcac acgacgcaua ccugaacgca gucgucggaa cagcacugau caagaaguac 3000 ccgaagcugg aaagcgaauu cgucuacgga gacuacaagg ucuacgacgu cagaaagaug 3060 aucgcaaaga gcgaacagga aaucggaaag gcaacagcaa aguacuucuu cuacagcaac 3120 aucaugaacu ucuucaagac agaaaucaca cuggcaaacg gagaaaucag aaagagaccg 3180 cugaucgaaa caaacggaga aacaggagaa aucgucuggg acaagggaag agacuucgca 3240 acagucagaa agguccugag caugccgcag gucaacaucg ucaagaagac agaaguccag 3300 acaggaggau ucagcaagga aagcauccug ccgaagagaa acagcgacaa gcugaucgca 3360 agaaagaagg acugggaccc gaagaaguac ggaggauucg acagcccgac agucgcauac 3420 agcguccugg ucgucgcaaa ggucgaaaag ggaaagagca agaagcugaa gagcgucaag 3480 gaacugcugg gaaucacaau cauggaaaga agcagcuucg aaaagaaccc gaucgacuuc 3540 cuggaagcaa agggauacaa ggaagucaag aaggaccuga ucaucaagcu gccgaaguac 3600 agccuguucg aacuggaaaa cggaagaaag agaaugcugg caagcgcagg agaacugcag 3660 aagggaaacg aacuggcacu gccgagcaag uacgucaacu uccuguaccu ggcaagccac 3720 uacgaaaagc ugaagggaag cccggaagac aacgaacaga agcagcuguu cgucgaacag 3780 cacaagcacu accuggacga aaucaucgaa cagaucagcg aauucagcaa gagagucauc 3840 cuggcagacg caaaccugga caagguccug agcgcauaca acaagcacag agacaagccg 3900 aucagagaac aggcagaaaa caucauccac cuguucacac ugacaaaccu gggagcaccg 3960 gcagcauuca aguacuucga cacaacaauc gacagaaaga gauacacaag cacaaaggaa 4020 guccuggacg caacacugau ccaccagagc aucacaggac uguacgaaac aagaaucgac 4080 cugagccagc ugggaggaga cggaggagga agcccgaaga agaagagaaa gguc 4134 <210> 11 <211> 4134 <212> ARN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 11 gacaagaagu acagcaucgg acuggcaauc ggaacaaaca gcgucggaug ggcagucauc 60 acagacgaau acaagguccc gagcaagaag uucaaggucc ugggaaacac agacagacac 120 agcaucaaga agaaccugau cggagcacug cuguucgaca gcggagaaac agcagaagca 180 acaagacuga agagaacagc aagaagaaga uacacaagaa gaaagaacag aaucugcuac 240 cugcaggaaa ucuucagcaa cgaaauggca aaggucgacg acagcuucuu ccacagacug 300 gaagaaagcu uccuggucga agaagacaag aagcacgaaa gacacccgau cuucggaaac 360 aucgucgacg aagucgcaua ccacgaaaag uacccgacaa ucuaccaccu gagaaagaag 420 cuggucgaca gcacagacaa ggcagaccug agacugaucu accuggcacu ggcacacaug 480 aucaaguuca gaggacacuu ccugaucgaa ggagaccuga acccggacaa cagcgacguc 540 gacaagcugu ucauccagcu gguccagaca uacaaccagc uguucgaaga aaacccgauc 600 aacgcaagcg gagucgacgc aaaggcaauc cugagcgcaa gacugagcaa gagcagaaga 660 cuggaaaacc ugaucgcaca gcugccggga gaaaagaaga acggacuguu cggaaaccug 720 aucgcacuga gccugggacu gacaccgaac uucaagagca acuucgaccu ggcagaagac 780 gcaaagcugc agcugagcaa ggacacauac gacgacgacc uggacaaccu gcuggcacag 840 aucggagacc aguacgcaga ccuguuccug gcagcaaaga accugagcga cgcaauccug 900 cugagcgaca uccugagagu caacacagaa aucacaaagg caccgcugag cgcaagcaug 960 aucaagagau acgacgaaca ccaccaggac cugacacugc ugaaggcacu ggucagacag 1020 cagcugccgg aaaaguacaa ggaaaucuuc uucgaccaga gcaagaacgg auacgcagga 1080 uacaucgacg gaggagcaag ccaggaagaa uucuacaagu ucaucaagcc gauccuggaa 1140 aagauggacg gaacagaaga acugcugguc aagcugaaca gagaagaccu gcugagaaag 1200 cagagaacau ucgacaacgg aagcaucccg caccagaucc accugggaga acugcacgca 1260 auccugagaa gacaggaaga cuucuacccg uuccugaagg acaacagaga aaagaucgaa 1320 aagauccuga cauucagaau cccguacuac gucggaccgc uggcaagagg aaacagcaga 1380 uucgcaugga ugacaagaaa gagcgaagaa acaaucacac cguggaacuu cgaagaaguc 1440 gucgacaagg gagcaagcgc acagagcuuc aucgaaagaa ugacaaacuu cgacaagaac 1500 cugccgaacg aaaagguccu gccgaagcac agccugcugu acgaauacuu cacagucuac 1560 aacgaacuga caaaggucaa guacgucaca gaaggaauga gaaagccggc auuccugagc 1620 ggagaacaga agaaggcaau cgucgaccug cuguucaaga caaacagaaa ggucacaguc 1680 aagcagcuga aggaagacua cuucaagaag aucgaaugcu ucgacagcgu cgaaaucagc 1740 ggagucgaag acagauucaa cgcaagccug ggaacauacc acgaccugcu gaagaucauc 1800 aaggacaagg acuuccugga caacgaagaa aacgaagaca uccuggaaga caucguccug 1860 acacugacac uguucgaaga cagagaaaug aucgaagaaa gacugaagac auacgcacac 1920 cuguucgacg acaaggucau gaagcagcug aagagaagaa gauacacagg auggggaaga 1980 cugagcagaa agcugaucaa cggaaucaga gacaagcaga gcggaaagac aauccuggac 2040 uuccugaaga gcgacggauu cgcaaacaga aacuucaugc agcugaucca cgacgacagc 2100 cugacauuca aggaagacau ccagaaggca caggucagcg gacagggaga cagccugcac 2160 gaacacaucg caaaccuggc aggaagcccg gcaaucaaga agggaauccu gcagacaguc 2220 aaggucgucg acgaacuggu caaggucaug ggaagacaca agccggaaaa caucgucauc 2280 gaaauggcaa gagaaaacca gacaacacag aagggacaga agaacagcag agaaagaaug 2340 aagagaaucg aagaaggaau caaggaacug ggaagccaga uccugaagga acacccgguc 2400 gaaaacacac agcugcagaa cgaaaagcug uaccuguacu accugcagaa cggaagagac 2460 auguacgucg accaggaacu ggacaucaac agacugagcg acuacgacgu cgaccacauc 2520 gucccgcaga gcuuccugaa ggacgacagc aucgacaaca agguccugac aagaagcgac 2580 aagaacagag gaaagagcga caacgucccg agcgaagaag ucgucaagaa gaugaagaac 2640 uacuggagac agcugcugaa cgcaaagcug aucacacaga gaaaguucga caaccugaca 2700 aaggcagaga gaggaggacu gagcgaacug gacaaggcag gauucaucaa gagacagcug 2760 gucgaaacaa gacagaucac aaagcacguc gcacagaucc uggacagcag aaugaacaca 2820 aaguacgacg aaaacgacaa gcugaucaga gaagucaagg ucaucacacu gaagagcaag 2880 cuggucagcg acuucagaaa ggacuuccag uucuacaagg ucagagaaau caacaacuac 2940 caccacgcac acgacgcaua ccugaacgca gucgucggaa cagcacugau caagaaguac 3000 ccgaagcugg aaagcgaauu cgucuacgga gacuacaagg ucuacgacgu cagaaagaug 3060 aucgcaaaga gcgaacagga aaucggaaag gcaacagcaa aguacuucuu cuacagcaac 3120 aucaugaacu ucuucaagac agaaaucaca cuggcaaacg gagaaaucag aaagagaccg 3180 cugaucgaaa caaacggaga aacaggagaa aucgucuggg acaagggaag agacuucgca 3240 acagucagaa agguccugag caugccgcag gucaacaucg ucaagaagac agaaguccag 3300 acaggaggau ucagcaagga aagcauccug ccgaagagaa acagcgacaa gcugaucgca 3360 agaaagaagg acugggaccc gaagaaguac ggaggauucg acagcccgac agucgcauac 3420 agcguccugg ucgucgcaaa ggucgaaaag ggaaagagca agaagcugaa gagcgucaag 3480 gaacugcugg gaaucacaau cauggaaaga agcagcuucg aaaagaaccc gaucgacuuc 3540 cuggaagcaa agggauacaa ggaagucaag aaggaccuga ucaucaagcu gccgaaguac 3600 agccuguucg aacuggaaaa cggaagaaag agaaugcugg caagcgcagg agaacugcag 3660 aagggaaacg aacuggcacu gccgagcaag uacgucaacu uccuguaccu ggcaagccac 3720 uacgaaaagc ugaagggaag cccggaagac aacgaacaga agcagcuguu cgucgaacag 3780 cacaagcacu accuggacga aaucaucgaa cagaucagcg aauucagcaa gagagucauc 3840 cuggcagacg caaaccugga caagguccug agcgcauaca acaagcacag agacaagccg 3900 aucagagaac aggcagaaaa caucauccac cuguucacac ugacaaaccu gggagcaccg 3960 gcagcauuca aguacuucga cacaacaauc gacagaaaga gauacacaag cacaaaggaa 4020 guccuggacg caacacugau ccaccagagc aucacaggac uguacgaaac aagaaucgac 4080 cugagccagc ugggaggaga cggaggagga agcccgaaga agaagagaaa gguc 4134 <210> 12 <211> 4134 <212> ARN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 12 gacaagaagu acagcaucgg acuggcaauc ggaacaaaca gcgucggaug ggcagucauc 60 acagacgaau acaagguccc gagcaagaag uucaaggucc ugggaaacac agacagacac 120 agcaucaaga agaaccugau cggagcacug cuguucgaca gcggagaaac agcagaagca 180 acaagacuga agagaacagc aagaagaaga uacacaagaa gaaagaacag aaucugcuac 240 cugcaggaaa ucuucagcaa cgaaauggca aaggucgacg acagcuucuu ccacagacug 300 gaagaaagcu uccuggucga agaagacaag aagcacgaaa gacacccgau cuucggaaac 360 aucgucgacg aagucgcaua ccacgaaaag uacccgacaa ucuaccaccu gagaaagaag 420 cuggucgaca gcacagacaa ggcagaccug agacugaucu accuggcacu ggcacacaug 480 aucaaguuca gaggacacuu ccugaucgaa ggagaccuga acccggacaa cagcgacguc 540 gacaagcugu ucauccagcu gguccagaca uacaaccagc uguucgaaga aaacccgauc 600 aacgcaagcg gagucgacgc aaaggcaauc cugagcgcaa gacugagcaa gagcagaaga 660 cuggaaaacc ugaucgcaca gcugccggga gaaaagaaga acggacuguu cggaaaccug 720 aucgcacuga gccugggacu gacaccgaac uucaagagca acuucgaccu ggcagaagac 780 gcaaagcugc agcugagcaa ggacacauac gacgacgacc uggacaaccu gcuggcacag 840 aucggagacc aguacgcaga ccuguuccug gcagcaaaga accugagcga cgcaauccug 900 cugagcgaca uccugagagu caacacagaa aucacaaagg caccgcugag cgcaagcaug 960 aucaagagau acgacgaaca ccaccaggac cugacacugc ugaaggcacu ggucagacag 1020 cagcugccgg aaaaguacaa ggaaaucuuc uucgaccaga gcaagaacgg auacgcagga 1080 uacaucgacg gaggagcaag ccaggaagaa uucuacaagu ucaucaagcc gauccuggaa 1140 aagauggacg gaacagaaga acugcugguc aagcugaaca gagaagaccu gcugagaaag 1200 cagagaacau ucgacaacgg aagcaucccg caccagaucc accugggaga acugcacgca 1260 auccugagaa gacaggaaga cuucuacccg uuccugaagg acaacagaga aaagaucgaa 1320 aagauccuga cauucagaau cccguacuac gucggaccgc uggcaagagg aaacagcaga 1380 uucgcaugga ugacaagaaa gagcgaagaa acaaucacac cguggaacuu cgaagaaguc 1440 gucgacaagg gagcaagcgc acagagcuuc aucgaaagaa ugacaaacuu cgacaagaac 1500 cugccgaacg aaaagguccu gccgaagcac agccugcugu acgaauacuu cacagucuac 1560 aacgaacuga caaaggucaa guacgucaca gaaggaauga gaaagccggc auuccugagc 1620 ggagaacaga agaaggcaau cgucgaccug cuguucaaga caaacagaaa ggucacaguc 1680 aagcagcuga aggaagacua cuucaagaag aucgaaugcu ucgacagcgu cgaaaucagc 1740 ggagucgaag acagauucaa cgcaagccug ggaacauacc acgaccugcu gaagaucauc 1800 aaggacaagg acuuccugga caacgaagaa aacgaagaca uccuggaaga caucguccug 1860 acacugacac uguucgaaga cagagaaaug aucgaagaaa gacugaagac auacgcacac 1920 cuguucgacg acaaggucau gaagcagcug aagagaagaa gauacacagg auggggaaga 1980 cugagcagaa agcugaucaa cggaaucaga gacaagcaga gcggaaagac aauccuggac 2040 uuccugaaga gcgacggauu cgcaaacaga aacuucaugc agcugaucca cgacgacagc 2100 cugacauuca aggaagacau ccagaaggca caggucagcg gacagggaga cagccugcac 2160 gaacacaucg caaaccuggc aggaagcccg gcaaucaaga agggaauccu gcagacaguc 2220 aaggucgucg acgaacuggu caaggucaug ggaagacaca agccggaaaa caucgucauc 2280 gaaauggcaa gagaaaacca gacaacacag aagggacaga agaacagcag agaaagaaug 2340 aagagaaucg aagaaggaau caaggaacug ggaagccaga uccugaagga acacccgguc 2400 gaaaacacac agcugcagaa cgaaaagcug uaccuguacu accugcagaa cggaagagac 2460 auguacgucg accaggaacu ggacaucaac agacugagcg acuacgacgu cgacgcaauc 2520 gucccgcaga gcuuccugaa ggacgacagc aucgacaaca agguccugac aagaagcgac 2580 aagaacagag gaaagagcga caacgucccg agcgaagaag ucgucaagaa gaugaagaac 2640 uacuggagac agcugcugaa cgcaaagcug aucacacaga gaaaguucga caaccugaca 2700 aaggcagaga gaggaggacu gagcgaacug gacaaggcag gauucaucaa gagacagcug 2760 gucgaaacaa gacagaucac aaagcacguc gcacagaucc uggacagcag aaugaacaca 2820 aaguacgacg aaaacgacaa gcugaucaga gaagucaagg ucaucacacu gaagagcaag 2880 cuggucagcg acuucagaaa ggacuuccag uucuacaagg ucagagaaau caacaacuac 2940 caccacgcac acgacgcaua ccugaacgca gucgucggaa cagcacugau caagaaguac 3000 ccgaagcugg aaagcgaauu cgucuacgga gacuacaagg ucuacgacgu cagaaagaug 3060 aucgcaaaga gcgaacagga aaucggaaag gcaacagcaa aguacuucuu cuacagcaac 3120 aucaugaacu ucuucaagac agaaaucaca cuggcaaacg gagaaaucag aaagagaccg 3180 cugaucgaaa caaacggaga aacaggagaa aucgucuggg acaagggaag agacuucgca 3240 acagucagaa agguccugag caugccgcag gucaacaucg ucaagaagac agaaguccag 3300 acaggaggau ucagcaagga aagcauccug ccgaagagaa acagcgacaa gcugaucgca 3360 agaaagaagg acugggaccc gaagaaguac ggaggauucg acagcccgac agucgcauac 3420 agcguccugg ucgucgcaaa ggucgaaaag ggaaagagca agaagcugaa gagcgucaag 3480 gaacugcugg gaaucacaau cauggaaaga agcagcuucg aaaagaaccc gaucgacuuc 3540 cuggaagcaa agggauacaa ggaagucaag aaggaccuga ucaucaagcu gccgaaguac 3600 agccuguucg aacuggaaaa cggaagaaag agaaugcugg caagcgcagg agaacugcag 3660 aagggaaacg aacuggcacu gccgagcaag uacgucaacu uccuguaccu ggcaagccac 3720 uacgaaaagc ugaagggaag cccggaagac aacgaacaga agcagcuguu cgucgaacag 3780 cacaagcacu accuggacga aaucaucgaa cagaucagcg aauucagcaa gagagucauc 3840 cuggcagacg caaaccugga caagguccug agcgcauaca acaagcacag agacaagccg 3900 aucagagaac aggcagaaaa caucauccac cuguucacac ugacaaaccu gggagcaccg 3960 gcagcauuca aguacuucga cacaacaauc gacagaaaga gauacacaag cacaaaggaa 4020 guccuggacg caacacugau ccaccagagc aucacaggac uguacgaaac aagaaucgac 4080 cugagccagc ugggaggaga cggaggagga agcccgaaga agaagagaaa gguc 4134 <210> 13 <211> 1368 <212> PRT <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polipéptido sintético" <400> 13 Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 1 5 10 15 Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 20 25 30 Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 35 40 45 Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 65 70 75 80 Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 100 105 110 His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 115 120 125 His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 130 135 140 Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 145 150 155 160 Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 165 170 175 Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 180 185 190 Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 195 200 205 Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 210 215 220 Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 225 230 235 240 Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 245 250 255 Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 260 265 270 Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 275 280 285 Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 290 295 300 Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 325 330 335 Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 340 345 350 Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 355 360 365 Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 370 375 380 Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 385 390 395 400 Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 405 410 415 Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 420 425 430 Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 450 455 460 Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 465 470 475 480 Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 485 490 495 Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 530 535 540 Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 545 550 555 560 Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 565 570 575 Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 580 585 590 Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 595 600 605 Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 610 615 620 Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 625 630 635 640 His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 645 650 655 Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 660 665 670 Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 675 680 685 Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 690 695 700 Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 705 710 715 720 His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 725 730 735 Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 740 745 750 Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 755 760 765 Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 770 775 780 Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 805 810 815 Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 820 825 830 Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 835 840 845 Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 850 855 860 Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 865 870 875 880 Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 885 890 895 Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 900 905 910 Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 915 920 925 Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 930 935 940 Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 945 950 955 960 Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 965 970 975 Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 980 985 990 Val Gly Thr Ala Leu Ile Lys Lys Tyr Pro Lys Leu Glu Ser Glu Phe 995 1000 1005 Val Tyr Gly Asp Tyr Lys Val Tyr Asp Val Arg Lys Met Ile Ala 1010 1015 1020 Lys Ser Glu Gln Glu Ile Gly Lys Ala Thr Ala Lys Tyr Phe Phe 1025 1030 1035 Tyr Ser Asn Ile Met Asn Phe Phe Lys Thr Glu Ile Thr Leu Ala 1040 1045 1050 Asn Gly Glu Ile Arg Lys Arg Pro Leu Ile Glu Thr Asn Gly Glu 1055 1060 1065 Thr Gly Glu Ile Val Trp Asp Lys Gly Arg Asp Phe Ala Thr Val 1070 1075 1080 Arg Lys Val Leu Ser Met Pro Gln Val Asn Ile Val Lys Lys Thr 1085 1090 1095 Glu Val Gln Thr Gly Gly Phe Ser Lys Glu Ser Ile Leu Pro Lys 1100 1105 1110 Arg Asn Ser Asp Lys Leu Ile Ala Arg Lys Lys Asp Trp Asp Pro 1115 1120 1125 Lys Lys Tyr Gly Gly Phe Asp Ser Pro Thr Val Ala Tyr Ser Val 1130 1135 1140 Leu Val Val Ala Lys Val Glu Lys Gly Lys Ser Lys Lys Leu Lys 1145 1150 1155 Ser Val Lys Glu Leu Leu Gly Ile Thr Ile Met Glu Arg Ser Ser 1160 1165 1170 Phe Glu Lys Asn Pro Ile Asp Phe Leu Glu Ala Lys Gly Tyr Lys 1175 1180 1185 Glu Val Lys Lys Asp Leu Ile Ile Lys Leu Pro Lys Tyr Ser Leu 1190 1195 1200 Phe Glu Leu Glu Asn Gly Arg Lys Arg Met Leu Ala Ser Ala Gly 1205 1210 1215 Glu Leu Gln Lys Gly Asn Glu Leu Ala Leu Pro Ser Lys Tyr Val 1220 1225 1230 Asn Phe Leu Tyr Leu Ala Ser His Tyr Glu Lys Leu Lys Gly Ser 1235 1240 1245 Pro Glu Asp Asn Glu Gln Lys Gln Leu Phe Val Glu Gln His Lys 1250 1255 1260 His Tyr Leu Asp Glu Ile Ile Glu Gln Ile Ser Glu Phe Ser Lys 1265 1270 1275 Arg Val Ile Leu Ala Asp Ala Asn Leu Asp Lys Val Leu Ser Ala 1280 1285 1290 Tyr Asn Lys His Arg Asp Lys Pro Ile Arg Glu Gln Ala Glu Asn 1295 1300 1305 Ile Ile His Leu Phe Thr Leu Thr Asn Leu Gly Ala Pro Ala Ala 1310 1315 1320 Phe Lys Tyr Phe Asp Thr Thr Ile Asp Arg Lys Arg Tyr Thr Ser 1325 1330 1335 Thr Lys Glu Val Leu Asp Ala Thr Leu Ile His Gln Ser Ile Thr 1340 1345 1350 Gly Leu Tyr Glu Thr Arg Ile Asp Leu Ser Gln Leu Gly Gly Asp 1355 1360 1365 <210> 14 <211> 4107 <212> ARN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 14 auggacaaga aguacagcau cggacuggac aucggaacaa acagcgucgg augggcaguc 60 aucacagacg aauacaaggu cccgagcaag aaguucaagg uccugggaaa cacagacaga 120 cacagcauca agaagaaccu gaucggagca cugcuguucg acagcggaga aacagcagaa 180 gcaacaagac ugaagagaac agcaagaaga agauacacaa gaagaaagaa cagaaucugc 240 uaccugcagg aaaucuucag caacgaaaug gcaaaggucg acgacagcuu cuuccacaga 300 cuggaagaaa gcuuccuggu cgaagaagac aagaagcacg aaagacaccc gaucuucgga 360 aacaucgucg acgaagucgc auaccacgaa aaguacccga caaucuacca ccugagaaag 420 aagcuggucg acagcacaga caaggcagac cugagacuga ucuaccuggc acuggcacac 480 augaucaagu ucagaggaca cuuccugauc gaaggagacc ugaacccgga caacagcgac 540 gucgacaagc uguucaucca gcugguccag acauacaacc agcuguucga agaaaacccg 600 aucaacgcaa gcggagucga cgcaaaggca auccugagcg caagacugag caagagcaga 660 agacuggaaa accugaucgc acagcugccg ggagaaaaga agaacggacu guucggaaac 720 cugaucgcac ugagccuggg acugacaccg aacuucaaga gcaacuucga ccuggcagaa 780 gacgcaaagc ugcagcugag caaggacaca uacgacgacg accuggacaa ccugcuggca 840 cagaucggag accaguacgc agaccuguuc cuggcagcaa agaaccugag cgacgcaauc 900 cugcugagcg acauccugag agucaacaca gaaaucacaa aggcaccgcu gagcgcaagc 960 augaucaaga gauacgacga acaccaccag gaccugacac ugcugaaggc acuggucaga 1020 cagcagcugc cggaaaagua caaggaaauc uucuucgacc agagcaagaa cggauacgca 1080 ggauacaucg acggaggagc aagccaggaa gaauucuaca aguucaucaa gccgauccug 1140 gaaaagaugg acggaacaga agaacugcug gucaagcuga acagagaaga ccugcugaga 1200 aagcagagaa cauucgacaa cggaagcauc ccgcaccaga uccaccuggg agaacugcac 1260 gcaauccuga gaagacagga agacuucuac ccguuccuga aggacaacag agaaaagauc 1320 gaaaagaucc ugacauucag aaucccguac uacgucggac cgcuggcaag aggaaacagc 1380 agauucgcau ggaugacaag aaagagcgaa gaaacaauca caccguggaa cuucgaagaa 1440 gucgucgaca agggagcaag cgcacagagc uucaucgaaa gaaugacaaa cuucgacaag 1500 aaccugccga acgaaaaggu ccugccgaag cacagccugc uguacgaaua cuucacaguc 1560 uacaacgaac ugacaaaggu caaguacguc acagaaggaa ugagaaagcc ggcauuccug 1620 agcggagaac agaagaaggc aaucgucgac cugcuguuca agacaaacag aaaggucaca 1680 gucaagcagc ugaaggaaga cuacuucaag aagaucgaau gcuucgacag cgucgaaauc 1740 agcggagucg aagacagauu caacgcaagc cugggaacau accacgaccu gcugaagauc 1800 aucaaggaca aggacuuccu ggacaacgaa gaaaacgaag acauccugga agacaucguc 1860 cugacacuga cacuguucga agacagagaa augaucgaag aaagacugaa gacauacgca 1920 caccuguucg acgacaaggu caugaagcag cugaagagaa gaagauacac aggaugggga 1980 agacugagca gaaagcugau caacggaauc agagacaagc agagcggaaa gacaauccug 2040 gacuuccuga agagcgacgg auucgcaaac agaaacuuca ugcagcugau ccacgacgac 2100 agccugacau ucaaggaaga cauccagaag gcacagguca gcggacaggg agacagccug 2160 cacgaacaca ucgcaaaccu ggcaggaagc ccggcaauca agaagggaau ccugcagaca 2220 gucaaggucg ucgacgaacu ggucaagguc augggaagac acaagccgga aaacaucguc 2280 aucgaaaugg caagagaaaa ccagacaaca cagaagggac agaagaacag cagagaaaga 2340 augaagagaa ucgaagaagg aaucaaggaa cugggaagcc agauccugaa ggaacacccg 2400 gucgaaaaca cacagcugca gaacgaaaag cuguaccugu acuaccugca gaacggaaga 2460 gacauguacg ucgaccagga acuggacauc aacagacuga gcgacuacga cgucgaccac 2520 aucgucccgc agagcuuccu gaaggacgac agcaucgaca acaagguccu gacaagaagc 2580 gacaagaaca gaggaaagag cgacaacguc ccgagcgaag aagucgucaa gaagaugaag 2640 aacuacugga gacagcugcu gaacgcaaag cugaucacac agagaaaguu cgacaaccug 2700 acaaaggcag agagaggagg acugagcgaa cuggacaagg caggauucau caagagacag 2760 cuggucgaaa caagacagau cacaaagcac gucgcacaga uccuggacag cagaaugaac 2820 acaaaguacg acgaaaacga caagcugauc agagaaguca aggucaucac acugaagagc 2880 aagcugguca gcgacuucag aaaggacuuc caguucuaca aggucagaga aaucaacaac 2940 uaccaccacg cacacgacgc auaccugaac gcagucgucg gaacagcacu gaucaagaag 3000 uacccgaagc uggaaagcga auucgucuac ggagacuaca aggucuacga cgucagaaag 3060 augaucgcaa agagcgaaca ggaaaucgga aaggcaacag caaaguacuu cuucuacagc 3120 aacaucauga acuucuucaa gacagaaauc acacuggcaa acggagaaau cagaaagaga 3180 ccgcugaucg aaacaaacgg agaaacagga gaaaucgucu gggacaaggg aagagacuuc 3240 gcaacaguca gaaagguccu gagcaugccg caggucaaca ucgucaagaa gacagaaguc 3300 cagacaggag gauucagcaa ggaaagcauc cugccgaaga gaaacagcga caagcugauc 3360 gcaagaaaga aggacuggga cccgaagaag uacggaggau ucgacagccc gacagucgca 3420 uacagcgucc uggucgucgc aaaggucgaa aagggaaaga gcaagaagcu gaagagcguc 3480 aaggaacugc ugggaaucac aaucauggaa agaagcagcu ucgaaaagaa cccgaucgac 3540 uuccuggaag caaagggaua caaggaaguc aagaaggacc ugaucaucaa gcugccgaag 3600 uacagccugu ucgaacugga aaacggaaga aagagaaugc uggcaagcgc aggagaacug 3660 cagaagggaa acgaacuggc acugccgagc aaguacguca acuuccugua ccuggcaagc 3720 cacuacgaaa agcugaaggg aagcccggaa gacaacgaac agaagcagcu guucgucgaa 3780 cagcacaagc acuaccugga cgaaaucauc gaacagauca gcgaauucag caagagaguc 3840 auccuggcag acgcaaaccu ggacaagguc cugagcgcau acaacaagca cagagacaag 3900 ccgaucagag aacaggcaga aaacaucauc caccuguuca cacugacaaa ccugggagca 3960 ccggcagcau ucaaguacuu cgacacaaca aucgacagaa agagauacac aagcacaaag 4020 gaaguccugg acgcaacacu gauccaccag agcaucacag gacuguacga aacaagaauc 4080 gaccugagcc agcugggagg agacuag 4107 <210> 15 <211> 4101 <212> ARN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 15 gacaagaagu acagcaucgg acuggacauc ggaacaaaca gcgucggaug ggcagucauc 60 acagacgaau acaagguccc gagcaagaag uucaaggucc ugggaaacac agacagacac 120 agcaucaaga agaaccugau cggagcacug cuguucgaca gcggagaaac agcagaagca 180 acaagacuga agagaacagc aagaagaaga uacacaagaa gaaagaacag aaucugcuac 240 cugcaggaaa ucuucagcaa cgaaauggca aaggucgacg acagcuucuu ccacagacug 300 gaagaaagcu uccuggucga agaagacaag aagcacgaaa gacacccgau cuucggaaac 360 aucgucgacg aagucgcaua ccacgaaaag uacccgacaa ucuaccaccu gagaaagaag 420 cuggucgaca gcacagacaa ggcagaccug agacugaucu accuggcacu ggcacacaug 480 aucaaguuca gaggacacuu ccugaucgaa ggagaccuga acccggacaa cagcgacguc 540 gacaagcugu ucauccagcu gguccagaca uacaaccagc uguucgaaga aaacccgauc 600 aacgcaagcg gagucgacgc aaaggcaauc cugagcgcaa gacugagcaa gagcagaaga 660 cuggaaaacc ugaucgcaca gcugccggga gaaaagaaga acggacuguu cggaaaccug 720 aucgcacuga gccugggacu gacaccgaac uucaagagca acuucgaccu ggcagaagac 780 gcaaagcugc agcugagcaa ggacacauac gacgacgacc uggacaaccu gcuggcacag 840 aucggagacc aguacgcaga ccuguuccug gcagcaaaga accugagcga cgcaauccug 900 cugagcgaca uccugagagu caacacagaa aucacaaagg caccgcugag cgcaagcaug 960 aucaagagau acgacgaaca ccaccaggac cugacacugc ugaaggcacu ggucagacag 1020 cagcugccgg aaaaguacaa ggaaaucuuc uucgaccaga gcaagaacgg auacgcagga 1080 uacaucgacg gaggagcaag ccaggaagaa uucuacaagu ucaucaagcc gauccuggaa 1140 aagauggacg gaacagaaga acugcugguc aagcugaaca gagaagaccu gcugagaaag 1200 cagagaacau ucgacaacgg aagcaucccg caccagaucc accugggaga acugcacgca 1260 auccugagaa gacaggaaga cuucuacccg uuccugaagg acaacagaga aaagaucgaa 1320 aagauccuga cauucagaau cccguacuac gucggaccgc uggcaagagg aaacagcaga 1380 uucgcaugga ugacaagaaa gagcgaagaa acaaucacac cguggaacuu cgaagaaguc 1440 gucgacaagg gagcaagcgc acagagcuuc aucgaaagaa ugacaaacuu cgacaagaac 1500 cugccgaacg aaaagguccu gccgaagcac agccugcugu acgaauacuu cacagucuac 1560 aacgaacuga caaaggucaa guacgucaca gaaggaauga gaaagccggc auuccugagc 1620 ggagaacaga agaaggcaau cgucgaccug cuguucaaga caaacagaaa ggucacaguc 1680 aagcagcuga aggaagacua cuucaagaag aucgaaugcu ucgacagcgu cgaaaucagc 1740 ggagucgaag acagauucaa cgcaagccug ggaacauacc acgaccugcu gaagaucauc 1800 aaggacaagg acuuccugga caacgaagaa aacgaagaca uccuggaaga caucguccug 1860 acacugacac uguucgaaga cagagaaaug aucgaagaaa gacugaagac auacgcacac 1920 cuguucgacg acaaggucau gaagcagcug aagagaagaa gauacacagg auggggaaga 1980 cugagcagaa agcugaucaa cggaaucaga gacaagcaga gcggaaagac aauccuggac 2040 uuccugaaga gcgacggauu cgcaaacaga aacuucaugc agcugaucca cgacgacagc 2100 cugacauuca aggaagacau ccagaaggca caggucagcg gacagggaga cagccugcac 2160 gaacacaucg caaaccuggc aggaagcccg gcaaucaaga agggaauccu gcagacaguc 2220 aaggucgucg acgaacuggu caaggucaug ggaagacaca agccggaaaa caucgucauc 2280 gaaauggcaa gagaaaacca gacaacacag aagggacaga agaacagcag agaaagaaug 2340 aagagaaucg aagaaggaau caaggaacug ggaagccaga uccugaagga acacccgguc 2400 gaaaacacac agcugcagaa cgaaaagcug uaccuguacu accugcagaa cggaagagac 2460 auguacgucg accaggaacu ggacaucaac agacugagcg acuacgacgu cgaccacauc 2520 gucccgcaga gcuuccugaa ggacgacagc aucgacaaca agguccugac aagaagcgac 2580 aagaacagag gaaagagcga caacgucccg agcgaagaag ucgucaagaa gaugaagaac 2640 uacuggagac agcugcugaa cgcaaagcug aucacacaga gaaaguucga caaccugaca 2700 aaggcagaga gaggaggacu gagcgaacug gacaaggcag gauucaucaa gagacagcug 2760 gucgaaacaa gacagaucac aaagcacguc gcacagaucc uggacagcag aaugaacaca 2820 aaguacgacg aaaacgacaa gcugaucaga gaagucaagg ucaucacacu gaagagcaag 2880 cuggucagcg acuucagaaa ggacuuccag uucuacaagg ucagagaaau caacaacuac 2940 caccacgcac acgacgcaua ccugaacgca gucgucggaa cagcacugau caagaaguac 3000 ccgaagcugg aaagcgaauu cgucuacgga gacuacaagg ucuacgacgu cagaaagaug 3060 aucgcaaaga gcgaacagga aaucggaaag gcaacagcaa aguacuucuu cuacagcaac 3120 aucaugaacu ucuucaagac agaaaucaca cuggcaaacg gagaaaucag aaagagaccg 3180 cugaucgaaa caaacggaga aacaggagaa aucgucuggg acaagggaag agacuucgca 3240 acagucagaa agguccugag caugccgcag gucaacaucg ucaagaagac agaaguccag 3300 acaggaggau ucagcaagga aagcauccug ccgaagagaa acagcgacaa gcugaucgca 3360 agaaagaagg acugggaccc gaagaaguac ggaggauucg acagcccgac agucgcauac 3420 agcguccugg ucgucgcaaa ggucgaaaag ggaaagagca agaagcugaa gagcgucaag 3480 gaacugcugg gaaucacaau cauggaaaga agcagcuucg aaaagaaccc gaucgacuuc 3540 cuggaagcaa agggauacaa ggaagucaag aaggaccuga ucaucaagcu gccgaaguac 3600 agccuguucg aacuggaaaa cggaagaaag agaaugcugg caagcgcagg agaacugcag 3660 aagggaaacg aacuggcacu gccgagcaag uacgucaacu uccuguaccu ggcaagccac 3720 uacgaaaagc ugaagggaag cccggaagac aacgaacaga agcagcuguu cgucgaacag 3780 cacaagcacu accuggacga aaucaucgaa cagaucagcg aauucagcaa gagagucauc 3840 cuggcagacg caaaccugga caagguccug agcgcauaca acaagcacag agacaagccg 3900 aucagagaac aggcagaaaa caucauccac cuguucacac ugacaaaccu gggagcaccg 3960 gcagcauuca aguacuucga cacaacaauc gacagaaaga gauacacaag cacaaaggaa 4020 guccuggacg caacacugau ccaccagagc aucacaggac uguacgaaac aagaaucgac 4080 cugagccagc ugggaggaga c 4101 <210> 16 <211> 1368 <212> PRT <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polipéptido sintético" <400> 16 Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 1 5 10 15 Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 20 25 30 Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 35 40 45 Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 65 70 75 80 Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 100 105 110 His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 115 120 125 His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 130 135 140 Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 145 150 155 160 Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 165 170 175 Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 180 185 190 Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 195 200 205 Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 210 215 220 Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 225 230 235 240 Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 245 250 255 Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 260 265 270 Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 275 280 285 Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 290 295 300 Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 325 330 335 Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 340 345 350 Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 355 360 365 Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 370 375 380 Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 385 390 395 400 Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 405 410 415 Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 420 425 430 Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 450 455 460 Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 465 470 475 480 Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 485 490 495 Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 530 535 540 Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 545 550 555 560 Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 565 570 575 Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 580 585 590 Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 595 600 605 Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 610 615 620 Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 625 630 635 640 His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 645 650 655 Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 660 665 670 Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 675 680 685 Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 690 695 700 Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 705 710 715 720 His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 725 730 735 Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 740 745 750 Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 755 760 765 Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 770 775 780 Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 805 810 815 Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 820 825 830 Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 835 840 845 Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 850 855 860 Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 865 870 875 880 Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 885 890 895 Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 900 905 910 Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 915 920 925 Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 930 935 940 Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 945 950 955 960 Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 965 970 975 Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 980 985 990 Val Gly Thr Ala Leu Ile Lys Lys Tyr Pro Lys Leu Glu Ser Glu Phe 995 1000 1005 Val Tyr Gly Asp Tyr Lys Val Tyr Asp Val Arg Lys Met Ile Ala 1010 1015 1020 Lys Ser Glu Gln Glu Ile Gly Lys Ala Thr Ala Lys Tyr Phe Phe 1025 1030 1035 Tyr Ser Asn Ile Met Asn Phe Phe Lys Thr Glu Ile Thr Leu Ala 1040 1045 1050 Asn Gly Glu Ile Arg Lys Arg Pro Leu Ile Glu Thr Asn Gly Glu 1055 1060 1065 Thr Gly Glu Ile Val Trp Asp Lys Gly Arg Asp Phe Ala Thr Val 1070 1075 1080 Arg Lys Val Leu Ser Met Pro Gln Val Asn Ile Val Lys Lys Thr 1085 1090 1095 Glu Val Gln Thr Gly Gly Phe Ser Lys Glu Ser Ile Leu Pro Lys 1100 1105 1110 Arg Asn Ser Asp Lys Leu Ile Ala Arg Lys Lys Asp Trp Asp Pro 1115 1120 1125 Lys Lys Tyr Gly Gly Phe Asp Ser Pro Thr Val Ala Tyr Ser Val 1130 1135 1140 Leu Val Val Ala Lys Val Glu Lys Gly Lys Ser Lys Lys Leu Lys 1145 1150 1155 Ser Val Lys Glu Leu Leu Gly Ile Thr Ile Met Glu Arg Ser Ser 1160 1165 1170 Phe Glu Lys Asn Pro Ile Asp Phe Leu Glu Ala Lys Gly Tyr Lys 1175 1180 1185 Glu Val Lys Lys Asp Leu Ile Ile Lys Leu Pro Lys Tyr Ser Leu 1190 1195 1200 Phe Glu Leu Glu Asn Gly Arg Lys Arg Met Leu Ala Ser Ala Gly 1205 1210 1215 Glu Leu Gln Lys Gly Asn Glu Leu Ala Leu Pro Ser Lys Tyr Val 1220 1225 1230 Asn Phe Leu Tyr Leu Ala Ser His Tyr Glu Lys Leu Lys Gly Ser 1235 1240 1245 Pro Glu Asp Asn Glu Gln Lys Gln Leu Phe Val Glu Gln His Lys 1250 1255 1260 His Tyr Leu Asp Glu Ile Ile Glu Gln Ile Ser Glu Phe Ser Lys 1265 1270 1275 Arg Val Ile Leu Ala Asp Ala Asn Leu Asp Lys Val Leu Ser Ala 1280 1285 1290 Tyr Asn Lys His Arg Asp Lys Pro Ile Arg Glu Gln Ala Glu Asn 1295 1300 1305 Ile Ile His Leu Phe Thr Leu Thr Asn Leu Gly Ala Pro Ala Ala 1310 1315 1320 Phe Lys Tyr Phe Asp Thr Thr Ile Asp Arg Lys Arg Tyr Thr Ser 1325 1330 1335 Thr Lys Glu Val Leu Asp Ala Thr Leu Ile His Gln Ser Ile Thr 1340 1345 1350 Gly Leu Tyr Glu Thr Arg Ile Asp Leu Ser Gln Leu Gly Gly Asp 1355 1360 1365 <210> 17 <211> 4107 <212> ARN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 17 auggacaaga aguacagcau cggacuggca aucggaacaa acagcgucgg augggcaguc 60 aucacagacg aauacaaggu cccgagcaag aaguucaagg uccugggaaa cacagacaga 120 cacagcauca agaagaaccu gaucggagca cugcuguucg acagcggaga aacagcagaa 180 gcaacaagac ugaagagaac agcaagaaga agauacacaa gaagaaagaa cagaaucugc 240 uaccugcagg aaaucuucag caacgaaaug gcaaaggucg acgacagcuu cuuccacaga 300 cuggaagaaa gcuuccuggu cgaagaagac aagaagcacg aaagacaccc gaucuucgga 360 aacaucgucg acgaagucgc auaccacgaa aaguacccga caaucuacca ccugagaaag 420 aagcuggucg acagcacaga caaggcagac cugagacuga ucuaccuggc acuggcacac 480 augaucaagu ucagaggaca cuuccugauc gaaggagacc ugaacccgga caacagcgac 540 gucgacaagc uguucaucca gcugguccag acauacaacc agcuguucga agaaaacccg 600 aucaacgcaa gcggagucga cgcaaaggca auccugagcg caagacugag caagagcaga 660 agacuggaaa accugaucgc acagcugccg ggagaaaaga agaacggacu guucggaaac 720 cugaucgcac ugagccuggg acugacaccg aacuucaaga gcaacuucga ccuggcagaa 780 gacgcaaagc ugcagcugag caaggacaca uacgacgacg accuggacaa ccugcuggca 840 cagaucggag accaguacgc agaccuguuc cuggcagcaa agaaccugag cgacgcaauc 900 cugcugagcg acauccugag agucaacaca gaaaucacaa aggcaccgcu gagcgcaagc 960 augaucaaga gauacgacga acaccaccag gaccugacac ugcugaaggc acuggucaga 1020 cagcagcugc cggaaaagua caaggaaauc uucuucgacc agagcaagaa cggauacgca 1080 ggauacaucg acggaggagc aagccaggaa gaauucuaca aguucaucaa gccgauccug 1140 gaaaagaugg acggaacaga agaacugcug gucaagcuga acagagaaga ccugcugaga 1200 aagcagagaa cauucgacaa cggaagcauc ccgcaccaga uccaccuggg agaacugcac 1260 gcaauccuga gaagacagga agacuucuac ccguuccuga aggacaacag agaaaagauc 1320 gaaaagaucc ugacauucag aaucccguac uacgucggac cgcuggcaag aggaaacagc 1380 agauucgcau ggaugacaag aaagagcgaa gaaacaauca caccguggaa cuucgaagaa 1440 gucgucgaca agggagcaag cgcacagagc uucaucgaaa gaaugacaaa cuucgacaag 1500 aaccugccga acgaaaaggu ccugccgaag cacagccugc uguacgaaua cuucacaguc 1560 uacaacgaac ugacaaaggu caaguacguc acagaaggaa ugagaaagcc ggcauuccug 1620 agcggagaac agaagaaggc aaucgucgac cugcuguuca agacaaacag aaaggucaca 1680 gucaagcagc ugaaggaaga cuacuucaag aagaucgaau gcuucgacag cgucgaaauc 1740 agcggagucg aagacagauu caacgcaagc cugggaacau accacgaccu gcugaagauc 1800 aucaaggaca aggacuuccu ggacaacgaa gaaaacgaag acauccugga agacaucguc 1860 cugacacuga cacuguucga agacagagaa augaucgaag aaagacugaa gacauacgca 1920 caccuguucg acgacaaggu caugaagcag cugaagagaa gaagauacac aggaugggga 1980 agacugagca gaaagcugau caacggaauc agagacaagc agagcggaaa gacaauccug 2040 gacuuccuga agagcgacgg auucgcaaac agaaacuuca ugcagcugau ccacgacgac 2100 agccugacau ucaaggaaga cauccagaag gcacagguca gcggacaggg agacagccug 2160 cacgaacaca ucgcaaaccu ggcaggaagc ccggcaauca agaagggaau ccugcagaca 2220 gucaaggucg ucgacgaacu ggucaagguc augggaagac acaagccgga aaacaucguc 2280 aucgaaaugg caagagaaaa ccagacaaca cagaagggac agaagaacag cagagaaaga 2340 augaagagaa ucgaagaagg aaucaaggaa cugggaagcc agauccugaa ggaacacccg 2400 gucgaaaaca cacagcugca gaacgaaaag cuguaccugu acuaccugca gaacggaaga 2460 gacauguacg ucgaccagga acuggacauc aacagacuga gcgacuacga cgucgaccac 2520 aucgucccgc agagcuuccu gaaggacgac agcaucgaca acaagguccu gacaagaagc 2580 gacaagaaca gaggaaagag cgacaacguc ccgagcgaag aagucgucaa gaagaugaag 2640 aacuacugga gacagcugcu gaacgcaaag cugaucacac agagaaaguu cgacaaccug 2700 acaaaggcag agagaggagg acugagcgaa cuggacaagg caggauucau caagagacag 2760 cuggucgaaa caagacagau cacaaagcac gucgcacaga uccuggacag cagaaugaac 2820 acaaaguacg acgaaaacga caagcugauc agagaaguca aggucaucac acugaagagc 2880 aagcugguca gcgacuucag aaaggacuuc caguucuaca aggucagaga aaucaacaac 2940 uaccaccacg cacacgacgc auaccugaac gcagucgucg gaacagcacu gaucaagaag 3000 uacccgaagc uggaaagcga auucgucuac ggagacuaca aggucuacga cgucagaaag 3060 augaucgcaa agagcgaaca ggaaaucgga aaggcaacag caaaguacuu cuucuacagc 3120 aacaucauga acuucuucaa gacagaaauc acacuggcaa acggagaaau cagaaagaga 3180 ccgcugaucg aaacaaacgg agaaacagga gaaaucgucu gggacaaggg aagagacuuc 3240 gcaacaguca gaaagguccu gagcaugccg caggucaaca ucgucaagaa gacagaaguc 3300 cagacaggag gauucagcaa ggaaagcauc cugccgaaga gaaacagcga caagcugauc 3360 gcaagaaaga aggacuggga cccgaagaag uacggaggau ucgacagccc gacagucgca 3420 uacagcgucc uggucgucgc aaaggucgaa aagggaaaga gcaagaagcu gaagagcguc 3480 aaggaacugc ugggaaucac aaucauggaa agaagcagcu ucgaaaagaa cccgaucgac 3540 uuccuggaag caaagggaua caaggaaguc aagaaggacc ugaucaucaa gcugccgaag 3600 uacagccugu ucgaacugga aaacggaaga aagagaaugc uggcaagcgc aggagaacug 3660 cagaagggaa acgaacuggc acugccgagc aaguacguca acuuccugua ccuggcaagc 3720 cacuacgaaa agcugaaggg aagcccggaa gacaacgaac agaagcagcu guucgucgaa 3780 cagcacaagc acuaccugga cgaaaucauc gaacagauca gcgaauucag caagagaguc 3840 auccuggcag acgcaaaccu ggacaagguc cugagcgcau acaacaagca cagagacaag 3900 ccgaucagag aacaggcaga aaacaucauc caccuguuca cacugacaaa ccugggagca 3960 ccggcagcau ucaaguacuu cgacacaaca aucgacagaa agagauacac aagcacaaag 4020 gaaguccugg acgcaacacu gauccaccag agcaucacag gacuguacga aacaagaauc 4080 gaccugagcc agcugggagg agacuag 4107 <210> 18 <211> 4101 <212> ARN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 18 gacaagaagu acagcaucgg acuggcaauc ggaacaaaca gcgucggaug ggcagucauc 60 acagacgaau acaagguccc gagcaagaag uucaaggucc ugggaaacac agacagacac 120 agcaucaaga agaaccugau cggagcacug cuguucgaca gcggagaaac agcagaagca 180 acaagacuga agagaacagc aagaagaaga uacacaagaa gaaagaacag aaucugcuac 240 cugcaggaaa ucuucagcaa cgaaauggca aaggucgacg acagcuucuu ccacagacug 300 gaagaaagcu uccuggucga agaagacaag aagcacgaaa gacacccgau cuucggaaac 360 aucgucgacg aagucgcaua ccacgaaaag uacccgacaa ucuaccaccu gagaaagaag 420 cuggucgaca gcacagacaa ggcagaccug agacugaucu accuggcacu ggcacacaug 480 aucaaguuca gaggacacuu ccugaucgaa ggagaccuga acccggacaa cagcgacguc 540 gacaagcugu ucauccagcu gguccagaca uacaaccagc uguucgaaga aaacccgauc 600 aacgcaagcg gagucgacgc aaaggcaauc cugagcgcaa gacugagcaa gagcagaaga 660 cuggaaaacc ugaucgcaca gcugccggga gaaaagaaga acggacuguu cggaaaccug 720 aucgcacuga gccugggacu gacaccgaac uucaagagca acuucgaccu ggcagaagac 780 gcaaagcugc agcugagcaa ggacacauac gacgacgacc uggacaaccu gcuggcacag 840 aucggagacc aguacgcaga ccuguuccug gcagcaaaga accugagcga cgcaauccug 900 cugagcgaca uccugagagu caacacagaa aucacaaagg caccgcugag cgcaagcaug 960 aucaagagau acgacgaaca ccaccaggac cugacacugc ugaaggcacu ggucagacag 1020 cagcugccgg aaaaguacaa ggaaaucuuc uucgaccaga gcaagaacgg auacgcagga 1080 uacaucgacg gaggagcaag ccaggaagaa uucuacaagu ucaucaagcc gauccuggaa 1140 aagauggacg gaacagaaga acugcugguc aagcugaaca gagaagaccu gcugagaaag 1200 cagagaacau ucgacaacgg aagcaucccg caccagaucc accugggaga acugcacgca 1260 auccugagaa gacaggaaga cuucuacccg uuccugaagg acaacagaga aaagaucgaa 1320 aagauccuga cauucagaau cccguacuac gucggaccgc uggcaagagg aaacagcaga 1380 uucgcaugga ugacaagaaa gagcgaagaa acaaucacac cguggaacuu cgaagaaguc 1440 gucgacaagg gagcaagcgc acagagcuuc aucgaaagaa ugacaaacuu cgacaagaac 1500 cugccgaacg aaaagguccu gccgaagcac agccugcugu acgaauacuu cacagucuac 1560 aacgaacuga caaaggucaa guacgucaca gaaggaauga gaaagccggc auuccugagc 1620 ggagaacaga agaaggcaau cgucgaccug cuguucaaga caaacagaaa ggucacaguc 1680 aagcagcuga aggaagacua cuucaagaag aucgaaugcu ucgacagcgu cgaaaucagc 1740 ggagucgaag acagauucaa cgcaagccug ggaacauacc acgaccugcu gaagaucauc 1800 aaggacaagg acuuccugga caacgaagaa aacgaagaca uccuggaaga caucguccug 1860 acacugacac uguucgaaga cagagaaaug aucgaagaaa gacugaagac auacgcacac 1920 cuguucgacg acaaggucau gaagcagcug aagagaagaa gauacacagg auggggaaga 1980 cugagcagaa agcugaucaa cggaaucaga gacaagcaga gcggaaagac aauccuggac 2040 uuccugaaga gcgacggauu cgcaaacaga aacuucaugc agcugaucca cgacgacagc 2100 cugacauuca aggaagacau ccagaaggca caggucagcg gacagggaga cagccugcac 2160 gaacacaucg caaaccuggc aggaagcccg gcaaucaaga agggaauccu gcagacaguc 2220 aaggucgucg acgaacuggu caaggucaug ggaagacaca agccggaaaa caucgucauc 2280 gaaauggcaa gagaaaacca gacaacacag aagggacaga agaacagcag agaaagaaug 2340 aagagaaucg aagaaggaau caaggaacug ggaagccaga uccugaagga acacccgguc 2400 gaaaacacac agcugcagaa cgaaaagcug uaccuguacu accugcagaa cggaagagac 2460 auguacgucg accaggaacu ggacaucaac agacugagcg acuacgacgu cgaccacauc 2520 gucccgcaga gcuuccugaa ggacgacagc aucgacaaca agguccugac aagaagcgac 2580 aagaacagag gaaagagcga caacgucccg agcgaagaag ucgucaagaa gaugaagaac 2640 uacuggagac agcugcugaa cgcaaagcug aucacacaga gaaaguucga caaccugaca 2700 aaggcagaga gaggaggacu gagcgaacug gacaaggcag gauucaucaa gagacagcug 2760 gucgaaacaa gacagaucac aaagcacguc gcacagaucc uggacagcag aaugaacaca 2820 aaguacgacg aaaacgacaa gcugaucaga gaagucaagg ucaucacacu gaagagcaag 2880 cuggucagcg acuucagaaa ggacuuccag uucuacaagg ucagagaaau caacaacuac 2940 caccacgcac acgacgcaua ccugaacgca gucgucggaa cagcacugau caagaaguac 3000 ccgaagcugg aaagcgaauu cgucuacgga gacuacaagg ucuacgacgu cagaaagaug 3060 aucgcaaaga gcgaacagga aaucggaaag gcaacagcaa aguacuucuu cuacagcaac 3120 aucaugaacu ucuucaagac agaaaucaca cuggcaaacg gagaaaucag aaagagaccg 3180 cugaucgaaa caaacggaga aacaggagaa aucgucuggg acaagggaag agacuucgca 3240 acagucagaa agguccugag caugccgcag gucaacaucg ucaagaagac agaaguccag 3300 acaggaggau ucagcaagga aagcauccug ccgaagagaa acagcgacaa gcugaucgca 3360 agaaagaagg acugggaccc gaagaaguac ggaggauucg acagcccgac agucgcauac 3420 agcguccugg ucgucgcaaa ggucgaaaag ggaaagagca agaagcugaa gagcgucaag 3480 gaacugcugg gaaucacaau cauggaaaga agcagcuucg aaaagaaccc gaucgacuuc 3540 cuggaagcaa agggauacaa ggaagucaag aaggaccuga ucaucaagcu gccgaaguac 3600 agccuguucg aacuggaaaa cggaagaaag agaaugcugg caagcgcagg agaacugcag 3660 aagggaaacg aacuggcacu gccgagcaag uacgucaacu uccuguaccu ggcaagccac 3720 uacgaaaagc ugaagggaag cccggaagac aacgaacaga agcagcuguu cgucgaacag 3780 cacaagcacu accuggacga aaucaucgaa cagaucagcg aauucagcaa gagagucauc 3840 cuggcagacg caaaccugga caagguccug agcgcauaca acaagcacag agacaagccg 3900 aucagagaac aggcagaaaa caucauccac cuguucacac ugacaaaccu gggagcaccg 3960 gcagcauuca aguacuucga cacaacaauc gacagaaaga gauacacaag cacaaaggaa 4020 guccuggacg caacacugau ccaccagagc aucacaggac uguacgaaac aagaaucgac 4080 cugagccagc ugggaggaga c 4101 <210> 19 <211> 1368 <212> PRT <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polipéptido sintético" <400> 19 Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 1 5 10 15 Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 20 25 30 Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 35 40 45 Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 65 70 75 80 Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 100 105 110 His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 115 120 125 His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 130 135 140 Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 145 150 155 160 Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 165 170 175 Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 180 185 190 Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 195 200 205 Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 210 215 220 Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 225 230 235 240 Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 245 250 255 Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 260 265 270 Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 275 280 285 Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 290 295 300 Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 325 330 335 Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 340 345 350 Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 355 360 365 Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 370 375 380 Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 385 390 395 400 Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 405 410 415 Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 420 425 430 Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 450 455 460 Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 465 470 475 480 Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 485 490 495 Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 530 535 540 Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 545 550 555 560 Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 565 570 575 Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 580 585 590 Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 595 600 605 Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 610 615 620 Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 625 630 635 640 His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 645 650 655 Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 660 665 670 Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 675 680 685 Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 690 695 700 Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 705 710 715 720 His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 725 730 735 Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 740 745 750 Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 755 760 765 Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 770 775 780 Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 805 810 815 Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 820 825 830 Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys 835 840 845 Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 850 855 860 Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 865 870 875 880 Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 885 890 895 Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 900 905 910 Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 915 920 925 Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 930 935 940 Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 945 950 955 960 Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 965 970 975 Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 980 985 990 Val Gly Thr Ala Leu Ile Lys Lys Tyr Pro Lys Leu Glu Ser Glu Phe 995 1000 1005 Val Tyr Gly Asp Tyr Lys Val Tyr Asp Val Arg Lys Met Ile Ala 1010 1015 1020 Lys Ser Glu Gln Glu Ile Gly Lys Ala Thr Ala Lys Tyr Phe Phe 1025 1030 1035 Tyr Ser Asn Ile Met Asn Phe Phe Lys Thr Glu Ile Thr Leu Ala 1040 1045 1050 Asn Gly Glu Ile Arg Lys Arg Pro Leu Ile Glu Thr Asn Gly Glu 1055 1060 1065 Thr Gly Glu Ile Val Trp Asp Lys Gly Arg Asp Phe Ala Thr Val 1070 1075 1080 Arg Lys Val Leu Ser Met Pro Gln Val Asn Ile Val Lys Lys Thr 1085 1090 1095 Glu Val Gln Thr Gly Gly Phe Ser Lys Glu Ser Ile Leu Pro Lys 1100 1105 1110 Arg Asn Ser Asp Lys Leu Ile Ala Arg Lys Lys Asp Trp Asp Pro 1115 1120 1125 Lys Lys Tyr Gly Gly Phe Asp Ser Pro Thr Val Ala Tyr Ser Val 1130 1135 1140 Leu Val Val Ala Lys Val Glu Lys Gly Lys Ser Lys Lys Leu Lys 1145 1150 1155 Ser Val Lys Glu Leu Leu Gly Ile Thr Ile Met Glu Arg Ser Ser 1160 1165 1170 Phe Glu Lys Asn Pro Ile Asp Phe Leu Glu Ala Lys Gly Tyr Lys 1175 1180 1185 Glu Val Lys Lys Asp Leu Ile Ile Lys Leu Pro Lys Tyr Ser Leu 1190 1195 1200 Phe Glu Leu Glu Asn Gly Arg Lys Arg Met Leu Ala Ser Ala Gly 1205 1210 1215 Glu Leu Gln Lys Gly Asn Glu Leu Ala Leu Pro Ser Lys Tyr Val 1220 1225 1230 Asn Phe Leu Tyr Leu Ala Ser His Tyr Glu Lys Leu Lys Gly Ser 1235 1240 1245 Pro Glu Asp Asn Glu Gln Lys Gln Leu Phe Val Glu Gln His Lys 1250 1255 1260 His Tyr Leu Asp Glu Ile Ile Glu Gln Ile Ser Glu Phe Ser Lys 1265 1270 1275 Arg Val Ile Leu Ala Asp Ala Asn Leu Asp Lys Val Leu Ser Ala 1280 1285 1290 Tyr Asn Lys His Arg Asp Lys Pro Ile Arg Glu Gln Ala Glu Asn 1295 1300 1305 Ile Ile His Leu Phe Thr Leu Thr Asn Leu Gly Ala Pro Ala Ala 1310 1315 1320 Phe Lys Tyr Phe Asp Thr Thr Ile Asp Arg Lys Arg Tyr Thr Ser 1325 1330 1335 Thr Lys Glu Val Leu Asp Ala Thr Leu Ile His Gln Ser Ile Thr 1340 1345 1350 Gly Leu Tyr Glu Thr Arg Ile Asp Leu Ser Gln Leu Gly Gly Asp 1355 1360 1365 <210> 20 <211> 4107 <212> ARN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 20 auggacaaga aguacagcau cggacuggca aucggaacaa acagcgucgg augggcaguc 60 aucacagacg aauacaaggu cccgagcaag aaguucaagg uccugggaaa cacagacaga 120 cacagcauca agaagaaccu gaucggagca cugcuguucg acagcggaga aacagcagaa 180 gcaacaagac ugaagagaac agcaagaaga agauacacaa gaagaaagaa cagaaucugc 240 uaccugcagg aaaucuucag caacgaaaug gcaaaggucg acgacagcuu cuuccacaga 300 cuggaagaaa gcuuccuggu cgaagaagac aagaagcacg aaagacaccc gaucuucgga 360 aacaucgucg acgaagucgc auaccacgaa aaguacccga caaucuacca ccugagaaag 420 aagcuggucg acagcacaga caaggcagac cugagacuga ucuaccuggc acuggcacac 480 augaucaagu ucagaggaca cuuccugauc gaaggagacc ugaacccgga caacagcgac 540 gucgacaagc uguucaucca gcugguccag acauacaacc agcuguucga agaaaacccg 600 aucaacgcaa gcggagucga cgcaaaggca auccugagcg caagacugag caagagcaga 660 agacuggaaa accugaucgc acagcugccg ggagaaaaga agaacggacu guucggaaac 720 cugaucgcac ugagccuggg acugacaccg aacuucaaga gcaacuucga ccuggcagaa 780 gacgcaaagc ugcagcugag caaggacaca uacgacgacg accuggacaa ccugcuggca 840 cagaucggag accaguacgc agaccuguuc cuggcagcaa agaaccugag cgacgcaauc 900 cugcugagcg acauccugag agucaacaca gaaaucacaa aggcaccgcu gagcgcaagc 960 augaucaaga gauacgacga acaccaccag gaccugacac ugcugaaggc acuggucaga 1020 cagcagcugc cggaaaagua caaggaaauc uucuucgacc agagcaagaa cggauacgca 1080 ggauacaucg acggaggagc aagccaggaa gaauucuaca aguucaucaa gccgauccug 1140 gaaaagaugg acggaacaga agaacugcug gucaagcuga acagagaaga ccugcugaga 1200 aagcagagaa cauucgacaa cggaagcauc ccgcaccaga uccaccuggg agaacugcac 1260 gcaauccuga gaagacagga agacuucuac ccguuccuga aggacaacag agaaaagauc 1320 gaaaagaucc ugacauucag aaucccguac uacgucggac cgcuggcaag aggaaacagc 1380 agauucgcau ggaugacaag aaagagcgaa gaaacaauca caccguggaa cuucgaagaa 1440 gucgucgaca agggagcaag cgcacagagc uucaucgaaa gaaugacaaa cuucgacaag 1500 aaccugccga acgaaaaggu ccugccgaag cacagccugc uguacgaaua cuucacaguc 1560 uacaacgaac ugacaaaggu caaguacguc acagaaggaa ugagaaagcc ggcauuccug 1620 agcggagaac agaagaaggc aaucgucgac cugcuguuca agacaaacag aaaggucaca 1680 gucaagcagc ugaaggaaga cuacuucaag aagaucgaau gcuucgacag cgucgaaauc 1740 agcggagucg aagacagauu caacgcaagc cugggaacau accacgaccu gcugaagauc 1800 aucaaggaca aggacuuccu ggacaacgaa gaaaacgaag acauccugga agacaucguc 1860 cugacacuga cacuguucga agacagagaa augaucgaag aaagacugaa gacauacgca 1920 caccuguucg acgacaaggu caugaagcag cugaagagaa gaagauacac aggaugggga 1980 agacugagca gaaagcugau caacggaauc agagacaagc agagcggaaa gacaauccug 2040 gacuuccuga agagcgacgg auucgcaaac agaaacuuca ugcagcugau ccacgacgac 2100 agccugacau ucaaggaaga cauccagaag gcacagguca gcggacaggg agacagccug 2160 cacgaacaca ucgcaaaccu ggcaggaagc ccggcaauca agaagggaau ccugcagaca 2220 gucaaggucg ucgacgaacu ggucaagguc augggaagac acaagccgga aaacaucguc 2280 aucgaaaugg caagagaaaa ccagacaaca cagaagggac agaagaacag cagagaaaga 2340 augaagagaa ucgaagaagg aaucaaggaa cugggaagcc agauccugaa ggaacacccg 2400 gucgaaaaca cacagcugca gaacgaaaag cuguaccugu acuaccugca gaacggaaga 2460 gacauguacg ucgaccagga acuggacauc aacagacuga gcgacuacga cgucgacgca 2520 aucgucccgc agagcuuccu gaaggacgac agcaucgaca acaagguccu gacaagaagc 2580 gacaagaaca gaggaaagag cgacaacguc ccgagcgaag aagucgucaa gaagaugaag 2640 aacuacugga gacagcugcu gaacgcaaag cugaucacac agagaaaguu cgacaaccug 2700 acaaaggcag agagaggagg acugagcgaa cuggacaagg caggauucau caagagacag 2760 cuggucgaaa caagacagau cacaaagcac gucgcacaga uccuggacag cagaaugaac 2820 acaaaguacg acgaaaacga caagcugauc agagaaguca aggucaucac acugaagagc 2880 aagcugguca gcgacuucag aaaggacuuc caguucuaca aggucagaga aaucaacaac 2940 uaccaccacg cacacgacgc auaccugaac gcagucgucg gaacagcacu gaucaagaag 3000 uacccgaagc uggaaagcga auucgucuac ggagacuaca aggucuacga cgucagaaag 3060 augaucgcaa agagcgaaca ggaaaucgga aaggcaacag caaaguacuu cuucuacagc 3120 aacaucauga acuucuucaa gacagaaauc acacuggcaa acggagaaau cagaaagaga 3180 ccgcugaucg aaacaaacgg agaaacagga gaaaucgucu gggacaaggg aagagacuuc 3240 gcaacaguca gaaagguccu gagcaugccg caggucaaca ucgucaagaa gacagaaguc 3300 cagacaggag gauucagcaa ggaaagcauc cugccgaaga gaaacagcga caagcugauc 3360 gcaagaaaga aggacuggga cccgaagaag uacggaggau ucgacagccc gacagucgca 3420 uacagcgucc uggucgucgc aaaggucgaa aagggaaaga gcaagaagcu gaagagcguc 3480 aaggaacugc ugggaaucac aaucauggaa agaagcagcu ucgaaaagaa cccgaucgac 3540 uuccuggaag caaagggaua caaggaaguc aagaaggacc ugaucaucaa gcugccgaag 3600 uacagccugu ucgaacugga aaacggaaga aagagaaugc uggcaagcgc aggagaacug 3660 cagaagggaa acgaacuggc acugccgagc aaguacguca acuuccugua ccuggcaagc 3720 cacuacgaaa agcugaaggg aagcccggaa gacaacgaac agaagcagcu guucgucgaa 3780 cagcacaagc acuaccugga cgaaaucauc gaacagauca gcgaauucag caagagaguc 3840 auccuggcag acgcaaaccu ggacaagguc cugagcgcau acaacaagca cagagacaag 3900 ccgaucagag aacaggcaga aaacaucauc caccuguuca cacugacaaa ccugggagca 3960 ccggcagcau ucaaguacuu cgacacaaca aucgacagaa agagauacac aagcacaaag 4020 gaaguccugg acgcaacacu gauccaccag agcaucacag gacuguacga aacaagaauc 4080 gaccugagcc agcugggagg agacuag 4107 <210> 21 <211> 4113 <212> ARN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 21 gacaagaagu acagcaucgg acuggcaauc ggaacaaaca gcgucggaug ggcagucauc 60 acagacgaau acaagguccc gagcaagaag uucaaggucc ugggaaacac agacagacac 120 agcaucaaga agaaccugau cggagcacug cuguucgaca gcggagaaac agcagaagca 180 acaagacuga agagaacagc aagaagaaga uacacaagaa gaaagaacag aaucugcuac 240 cugcaggaaa ucuucagcaa cgaaauggca aaggucgacg acagcuucuu ccacagacug 300 gaagaaagcu uccuggucga agaagacaag aagcacgaaa gacacccgau cuucggaaac 360 aucgucgacg aagucgcaua ccacgaaaag uacccgacaa ucuaccaccu gagaaagaag 420 cuggucgaca gcacagacaa ggcagaccug agacugaucu accuggcacu ggcacacaug 480 aucaaguuca gaggacacuu ccugaucgaa ggagaccuga acccggacaa cagcgacguc 540 gacaagcugu ucauccagcu gguccagaca uacaaccagc uguucgaaga aaacccgauc 600 aacgcaagcg gagucgacgc aaaggcaauc cugagcgcaa gacugagcaa gagcagaaga 660 cuggaaaacc ugaucgcaca gcugccggga gaaaagaaga acggacuguu cggaaaccug 720 aucgcacuga gccugggacu gacaccgaac uucaagagca acuucgaccu ggcagaagac 780 gcaaagcugc agcugagcaa ggacacauac gacgacgacc uggacaaccu gcuggcacag 840 aucggagacc aguacgcaga ccuguuccug gcagcaaaga accugagcga cgcaauccug 900 cugagcgaca uccugagagu caacacagaa aucacaaagg caccgcugag cgcaagcaug 960 aucaagagau acgacgaaca ccaccaggac cugacacugc ugaaggcacu ggucagacag 1020 cagcugccgg aaaaguacaa ggaaaucuuc uucgaccaga gcaagaacgg auacgcagga 1080 uacaucgacg gaggagcaag ccaggaagaa uucuacaagu ucaucaagcc gauccuggaa 1140 aagauggacg gaacagaaga acugcugguc aagcugaaca gagaagaccu gcugagaaag 1200 cagagaacau ucgacaacgg aagcaucccg caccagaucc accugggaga acugcacgca 1260 auccugagaa gacaggaaga cuucuacccg uuccugaagg acaacagaga aaagaucgaa 1320 aagauccuga cauucagaau cccguacuac gucggaccgc uggcaagagg aaacagcaga 1380 uucgcaugga ugacaagaaa gagcgaagaa acaaucacac cguggaacuu cgaagaaguc 1440 gucgacaagg gagcaagcgc acagagcuuc aucgaaagaa ugacaaacuu cgacaagaac 1500 cugccgaacg aaaagguccu gccgaagcac agccugcugu acgaauacuu cacagucuac 1560 aacgaacuga caaaggucaa guacgucaca gaaggaauga gaaagccggc auuccugagc 1620 ggagaacaga agaaggcaau cgucgaccug cuguucaaga caaacagaaa ggucacaguc 1680 aagcagcuga aggaagacua cuucaagaag aucgaaugcu ucgacagcgu cgaaaucagc 1740 ggagucgaag acagauucaa cgcaagccug ggaacauacc acgaccugcu gaagaucauc 1800 aaggacaagg acuuccugga caacgaagaa aacgaagaca uccuggaaga caucguccug 1860 acacugacac uguucgaaga cagagaaaug aucgaagaaa gacugaagac auacgcacac 1920 cuguucgacg acaaggucau gaagcagcug aagagaagaa gauacacagg auggggaaga 1980 cugagcagaa agcugaucaa cggaaucaga gacaagcaga gcggaaagac aauccuggac 2040 uuccugaaga gcgacggauu cgcaaacaga aacuucaugc agcugaucca cgacgacagc 2100 cugacauuca aggaagacau ccagaaggca caggucagcg gacagggaga cagccugcac 2160 gaacacaucg caaaccuggc aggaagcccg gcaaucaaga agggaauccu gcagacaguc 2220 aaggucgucg acgaacuggu caaggucaug ggaagacaca agccggaaaa caucgucauc 2280 gaaauggcaa gagaaaacca gacaacacag aagggacaga agaacagcag agaaagaaug 2340 aagagaaucg aagaaggaau caaggaacug ggaagccaga uccugaagga acacccgguc 2400 gaaaacacac agcugcagaa cgaaaagcug uaccuguacu accugcagaa cggaagagac 2460 auguacgucg accaggaacu ggacaucaac agacugagcg acuacgacgu cgacgcaauc 2520 gucccgcaga gcuuccugaa ggacgacagc aucgacaaca agguccugac aagaagcgac 2580 aagaacagag gaaagagcga caacgucccg agcgaagaag ucgucaagaa gaugaagaac 2640 uacuggagac agcugcugaa cgcaaagcug aucacacaga gaaaguucga caaccugaca 2700 aaggcagaga gaggaggacu gagcgaacug gacaaggcag gauucaucaa gagacagcug 2760 gucgaaacaa gacagaucac aaagcacguc gcacagaucc uggacagcag aaugaacaca 2820 aaguacgacg aaaacgacaa gcugaucaga gaagucaagg ucaucacacu gaagagcaag 2880 cuggucagcg acuucagaaa ggacuuccag uucuacaagg ucagagaaau caacaacuac 2940 caccacgcac acgacgcaua ccugaacgca gucgucggaa cagcacugau caagaaguac 3000 ccgaagcugg aaagcgaauu cgucuacgga gacuacaagg ucuacgacgu cagaaagaug 3060 aucgcaaaga gcgaacagga aaucggaaag gcaacagcaa aguacuucuu cuacagcaac 3120 aucaugaacu ucuucaagac agaaaucaca cuggcaaacg gagaaaucag aaagagaccg 3180 cugaucgaaa caaacggaga aacaggagaa aucgucuggg acaagggaag agacuucgca 3240 acagucagaa agguccugag caugccgcag gucaacaucg ucaagaagac agaaguccag 3300 acaggaggau ucagcaagga aagcauccug ccgaagagaa acagcgacaa gcugaucgca 3360 agaaagaagg acugggaccc gaagaaguac ggaggauucg acagcccgac agucgcauac 3420 agcguccugg ucgucgcaaa ggucgaaaag ggaaagagca agaagcugaa gagcgucaag 3480 gaacugcugg gaaucacaau cauggaaaga agcagcuucg aaaagaaccc gaucgacuuc 3540 cuggaagcaa agggauacaa ggaagucaag aaggaccuga ucaucaagcu gccgaaguac 3600 agccuguucg aacuggaaaa cggaagaaag agaaugcugg caagcgcagg agaacugcag 3660 aagggaaacg aacuggcacu gccgagcaag uacgucaacu uccuguaccu ggcaagccac 3720 uacgaaaagc ugaagggaag cccggaagac aacgaacaga agcagcuguu cgucgaacag 3780 cacaagcacu accuggacga aaucaucgaa cagaucagcg aauucagcaa gagagucauc 3840 cuggcagacg caaaccugga caagguccug agcgcauaca acaagcacag agacaagccg 3900 aucagagaac aggcagaaaa caucauccac cuguucacac ugacaaaccu gggagcaccg 3960 gcagcauuca aguacuucga cacaacaauc gacagaaaga gauacacaag cacaaaggaa 4020 guccuggacg caacacugau ccaccagagc aucacaggac uguacgaaac aagaaucgac 4080 cugagccagc ugggaggaga cggaggagga agc 4113 <210> 22 <211> 1392 <212> PRT <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polipéptido sintético" <400> 22 Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 1 5 10 15 Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 20 25 30 Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 35 40 45 Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 65 70 75 80 Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 100 105 110 His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 115 120 125 His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 130 135 140 Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 145 150 155 160 Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 165 170 175 Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 180 185 190 Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 195 200 205 Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 210 215 220 Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 225 230 235 240 Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 245 250 255 Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 260 265 270 Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 275 280 285 Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 290 295 300 Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 325 330 335 Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 340 345 350 Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 355 360 365 Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 370 375 380 Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 385 390 395 400 Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 405 410 415 Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 420 425 430 Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 450 455 460 Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 465 470 475 480 Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 485 490 495 Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 530 535 540 Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 545 550 555 560 Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 565 570 575 Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 580 585 590 Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 595 600 605 Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 610 615 620 Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 625 630 635 640 His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 645 650 655 Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 660 665 670 Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 675 680 685 Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 690 695 700 Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 705 710 715 720 His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 725 730 735 Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 740 745 750 Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 755 760 765 Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 770 775 780 Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 805 810 815 Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 820 825 830 Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 835 840 845 Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 850 855 860 Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 865 870 875 880 Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 885 890 895 Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 900 905 910 Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 915 920 925 Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 930 935 940 Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 945 950 955 960 Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 965 970 975 Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 980 985 990 Val Gly Thr Ala Leu Ile Lys Lys Tyr Pro Lys Leu Glu Ser Glu Phe 995 1000 1005 Val Tyr Gly Asp Tyr Lys Val Tyr Asp Val Arg Lys Met Ile Ala 1010 1015 1020 Lys Ser Glu Gln Glu Ile Gly Lys Ala Thr Ala Lys Tyr Phe Phe 1025 1030 1035 Tyr Ser Asn Ile Met Asn Phe Phe Lys Thr Glu Ile Thr Leu Ala 1040 1045 1050 Asn Gly Glu Ile Arg Lys Arg Pro Leu Ile Glu Thr Asn Gly Glu 1055 1060 1065 Thr Gly Glu Ile Val Trp Asp Lys Gly Arg Asp Phe Ala Thr Val 1070 1075 1080 Arg Lys Val Leu Ser Met Pro Gln Val Asn Ile Val Lys Lys Thr 1085 1090 1095 Glu Val Gln Thr Gly Gly Phe Ser Lys Glu Ser Ile Leu Pro Lys 1100 1105 1110 Arg Asn Ser Asp Lys Leu Ile Ala Arg Lys Lys Asp Trp Asp Pro 1115 1120 1125 Lys Lys Tyr Gly Gly Phe Asp Ser Pro Thr Val Ala Tyr Ser Val 1130 1135 1140 Leu Val Val Ala Lys Val Glu Lys Gly Lys Ser Lys Lys Leu Lys 1145 1150 1155 Ser Val Lys Glu Leu Leu Gly Ile Thr Ile Met Glu Arg Ser Ser 1160 1165 1170 Phe Glu Lys Asn Pro Ile Asp Phe Leu Glu Ala Lys Gly Tyr Lys 1175 1180 1185 Glu Val Lys Lys Asp Leu Ile Ile Lys Leu Pro Lys Tyr Ser Leu 1190 1195 1200 Phe Glu Leu Glu Asn Gly Arg Lys Arg Met Leu Ala Ser Ala Gly 1205 1210 1215 Glu Leu Gln Lys Gly Asn Glu Leu Ala Leu Pro Ser Lys Tyr Val 1220 1225 1230 Asn Phe Leu Tyr Leu Ala Ser His Tyr Glu Lys Leu Lys Gly Ser 1235 1240 1245 Pro Glu Asp Asn Glu Gln Lys Gln Leu Phe Val Glu Gln His Lys 1250 1255 1260 His Tyr Leu Asp Glu Ile Ile Glu Gln Ile Ser Glu Phe Ser Lys 1265 1270 1275 Arg Val Ile Leu Ala Asp Ala Asn Leu Asp Lys Val Leu Ser Ala 1280 1285 1290 Tyr Asn Lys His Arg Asp Lys Pro Ile Arg Glu Gln Ala Glu Asn 1295 1300 1305 Ile Ile His Leu Phe Thr Leu Thr Asn Leu Gly Ala Pro Ala Ala 1310 1315 1320 Phe Lys Tyr Phe Asp Thr Thr Ile Asp Arg Lys Arg Tyr Thr Ser 1325 1330 1335 Thr Lys Glu Val Leu Asp Ala Thr Leu Ile His Gln Ser Ile Thr 1340 1345 1350 Gly Leu Tyr Glu Thr Arg Ile Asp Leu Ser Gln Leu Gly Gly Asp 1355 1360 1365 Gly Ser Gly Ser Pro Lys Lys Lys Arg Lys Val Asp Gly Ser Pro 1370 1375 1380 Lys Lys Lys Arg Lys Val Asp Ser Gly 1385 1390 <210> 23 <211> 4179 <212> ARN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 23 auggacaaga aguacagcau cggacuggac aucggaacaa acagcgucgg augggcaguc 60 aucacagacg aauacaaggu cccgagcaag aaguucaagg uccugggaaa cacagacaga 120 cacagcauca agaagaaccu gaucggagca cugcuguucg acagcggaga aacagcagaa 180 gcaacaagac ugaagagaac agcaagaaga agauacacaa gaagaaagaa cagaaucugc 240 uaccugcagg aaaucuucag caacgaaaug gcaaaggucg acgacagcuu cuuccacaga 300 cuggaagaaa gcuuccuggu cgaagaagac aagaagcacg aaagacaccc gaucuucgga 360 aacaucgucg acgaagucgc auaccacgaa aaguacccga caaucuacca ccugagaaag 420 aagcuggucg acagcacaga caaggcagac cugagacuga ucuaccuggc acuggcacac 480 augaucaagu ucagaggaca cuuccugauc gaaggagacc ugaacccgga caacagcgac 540 gucgacaagc uguucaucca gcugguccag acauacaacc agcuguucga agaaaacccg 600 aucaacgcaa gcggagucga cgcaaaggca auccugagcg caagacugag caagagcaga 660 agacuggaaa accugaucgc acagcugccg ggagaaaaga agaacggacu guucggaaac 720 cugaucgcac ugagccuggg acugacaccg aacuucaaga gcaacuucga ccuggcagaa 780 gacgcaaagc ugcagcugag caaggacaca uacgacgacg accuggacaa ccugcuggca 840 cagaucggag accaguacgc agaccuguuc cuggcagcaa agaaccugag cgacgcaauc 900 cugcugagcg acauccugag agucaacaca gaaaucacaa aggcaccgcu gagcgcaagc 960 augaucaaga gauacgacga acaccaccag gaccugacac ugcugaaggc acuggucaga 1020 cagcagcugc cggaaaagua caaggaaauc uucuucgacc agagcaagaa cggauacgca 1080 ggauacaucg acggaggagc aagccaggaa gaauucuaca aguucaucaa gccgauccug 1140 gaaaagaugg acggaacaga agaacugcug gucaagcuga acagagaaga ccugcugaga 1200 aagcagagaa cauucgacaa cggaagcauc ccgcaccaga uccaccuggg agaacugcac 1260 gcaauccuga gaagacagga agacuucuac ccguuccuga aggacaacag agaaaagauc 1320 gaaaagaucc ugacauucag aaucccguac uacgucggac cgcuggcaag aggaaacagc 1380 agauucgcau ggaugacaag aaagagcgaa gaaacaauca caccguggaa cuucgaagaa 1440 gucgucgaca agggagcaag cgcacagagc uucaucgaaa gaaugacaaa cuucgacaag 1500 aaccugccga acgaaaaggu ccugccgaag cacagccugc uguacgaaua cuucacaguc 1560 uacaacgaac ugacaaaggu caaguacguc acagaaggaa ugagaaagcc ggcauuccug 1620 agcggagaac agaagaaggc aaucgucgac cugcuguuca agacaaacag aaaggucaca 1680 gucaagcagc ugaaggaaga cuacuucaag aagaucgaau gcuucgacag cgucgaaauc 1740 agcggagucg aagacagauu caacgcaagc cugggaacau accacgaccu gcugaagauc 1800 aucaaggaca aggacuuccu ggacaacgaa gaaaacgaag acauccugga agacaucguc 1860 cugacacuga cacuguucga agacagagaa augaucgaag aaagacugaa gacauacgca 1920 caccuguucg acgacaaggu caugaagcag cugaagagaa gaagauacac aggaugggga 1980 agacugagca gaaagcugau caacggaauc agagacaagc agagcggaaa gacaauccug 2040 gacuuccuga agagcgacgg auucgcaaac agaaacuuca ugcagcugau ccacgacgac 2100 agccugacau ucaaggaaga cauccagaag gcacagguca gcggacaggg agacagccug 2160 cacgaacaca ucgcaaaccu ggcaggaagc ccggcaauca agaagggaau ccugcagaca 2220 gucaaggucg ucgacgaacu ggucaagguc augggaagac acaagccgga aaacaucguc 2280 aucgaaaugg caagagaaaa ccagacaaca cagaagggac agaagaacag cagagaaaga 2340 augaagagaa ucgaagaagg aaucaaggaa cugggaagcc agauccugaa ggaacacccg 2400 gucgaaaaca cacagcugca gaacgaaaag cuguaccugu acuaccugca gaacggaaga 2460 gacauguacg ucgaccagga acuggacauc aacagacuga gcgacuacga cgucgaccac 2520 aucgucccgc agagcuuccu gaaggacgac agcaucgaca acaagguccu gacaagaagc 2580 gacaagaaca gaggaaagag cgacaacguc ccgagcgaag aagucgucaa gaagaugaag 2640 aacuacugga gacagcugcu gaacgcaaag cugaucacac agagaaaguu cgacaaccug 2700 acaaaggcag agagaggagg acugagcgaa cuggacaagg caggauucau caagagacag 2760 cuggucgaaa caagacagau cacaaagcac gucgcacaga uccuggacag cagaaugaac 2820 acaaaguacg acgaaaacga caagcugauc agagaaguca aggucaucac acugaagagc 2880 aagcugguca gcgacuucag aaaggacuuc caguucuaca aggucagaga aaucaacaac 2940 uaccaccacg cacacgacgc auaccugaac gcagucgucg gaacagcacu gaucaagaag 3000 uacccgaagc uggaaagcga auucgucuac ggagacuaca aggucuacga cgucagaaag 3060 augaucgcaa agagcgaaca ggaaaucgga aaggcaacag caaaguacuu cuucuacagc 3120 aacaucauga acuucuucaa gacagaaauc acacuggcaa acggagaaau cagaaagaga 3180 ccgcugaucg aaacaaacgg agaaacagga gaaaucgucu gggacaaggg aagagacuuc 3240 gcaacaguca gaaagguccu gagcaugccg caggucaaca ucgucaagaa gacagaaguc 3300 cagacaggag gauucagcaa ggaaagcauc cugccgaaga gaaacagcga caagcugauc 3360 gcaagaaaga aggacuggga cccgaagaag uacggaggau ucgacagccc gacagucgca 3420 uacagcgucc uggucgucgc aaaggucgaa aagggaaaga gcaagaagcu gaagagcguc 3480 aaggaacugc ugggaaucac aaucauggaa agaagcagcu ucgaaaagaa cccgaucgac 3540 uuccuggaag caaagggaua caaggaaguc aagaaggacc ugaucaucaa gcugccgaag 3600 uacagccugu ucgaacugga aaacggaaga aagagaaugc uggcaagcgc aggagaacug 3660 cagaagggaa acgaacuggc acugccgagc aaguacguca acuuccugua ccuggcaagc 3720 cacuacgaaa agcugaaggg aagcccggaa gacaacgaac agaagcagcu guucgucgaa 3780 cagcacaagc acuaccugga cgaaaucauc gaacagauca gcgaauucag caagagaguc 3840 auccuggcag acgcaaaccu ggacaagguc cugagcgcau acaacaagca cagagacaag 3900 ccgaucagag aacaggcaga aaacaucauc caccuguuca cacugacaaa ccugggagca 3960 ccggcagcau ucaaguacuu cgacacaaca aucgacagaa agagauacac aagcacaaag 4020 gaaguccugg acgcaacacu gauccaccag agcaucacag gacuguacga aacaagaauc 4080 gaccugagcc agcugggagg agacggaagc ggaagcccga agaagaagag aaaggucgac 4140 ggaagcccga agaagaagag aaaggucgac agcggauag 4179 <210> 24 <211> 4173 <212> ARN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 24 gacaagaagu acagcaucgg acuggacauc ggaacaaaca gcgucggaug ggcagucauc 60 acagacgaau acaagguccc gagcaagaag uucaaggucc ugggaaacac agacagacac 120 agcaucaaga agaaccugau cggagcacug cuguucgaca gcggagaaac agcagaagca 180 acaagacuga agagaacagc aagaagaaga uacacaagaa gaaagaacag aaucugcuac 240 cugcaggaaa ucuucagcaa cgaaauggca aaggucgacg acagcuucuu ccacagacug 300 gaagaaagcu uccuggucga agaagacaag aagcacgaaa gacacccgau cuucggaaac 360 aucgucgacg aagucgcaua ccacgaaaag uacccgacaa ucuaccaccu gagaaagaag 420 cuggucgaca gcacagacaa ggcagaccug agacugaucu accuggcacu ggcacacaug 480 aucaaguuca gaggacacuu ccugaucgaa ggagaccuga acccggacaa cagcgacguc 540 gacaagcugu ucauccagcu gguccagaca uacaaccagc uguucgaaga aaacccgauc 600 aacgcaagcg gagucgacgc aaaggcaauc cugagcgcaa gacugagcaa gagcagaaga 660 cuggaaaacc ugaucgcaca gcugccggga gaaaagaaga acggacuguu cggaaaccug 720 aucgcacuga gccugggacu gacaccgaac uucaagagca acuucgaccu ggcagaagac 780 gcaaagcugc agcugagcaa ggacacauac gacgacgacc uggacaaccu gcuggcacag 840 aucggagacc aguacgcaga ccuguuccug gcagcaaaga accugagcga cgcaauccug 900 cugagcgaca uccugagagu caacacagaa aucacaaagg caccgcugag cgcaagcaug 960 aucaagagau acgacgaaca ccaccaggac cugacacugc ugaaggcacu ggucagacag 1020 cagcugccgg aaaaguacaa ggaaaucuuc uucgaccaga gcaagaacgg auacgcagga 1080 uacaucgacg gaggagcaag ccaggaagaa uucuacaagu ucaucaagcc gauccuggaa 1140 aagauggacg gaacagaaga acugcugguc aagcugaaca gagaagaccu gcugagaaag 1200 cagagaacau ucgacaacgg aagcaucccg caccagaucc accugggaga acugcacgca 1260 auccugagaa gacaggaaga cuucuacccg uuccugaagg acaacagaga aaagaucgaa 1320 aagauccuga cauucagaau cccguacuac gucggaccgc uggcaagagg aaacagcaga 1380 uucgcaugga ugacaagaaa gagcgaagaa acaaucacac cguggaacuu cgaagaaguc 1440 gucgacaagg gagcaagcgc acagagcuuc aucgaaagaa ugacaaacuu cgacaagaac 1500 cugccgaacg aaaagguccu gccgaagcac agccugcugu acgaauacuu cacagucuac 1560 aacgaacuga caaaggucaa guacgucaca gaaggaauga gaaagccggc auuccugagc 1620 ggagaacaga agaaggcaau cgucgaccug cuguucaaga caaacagaaa ggucacaguc 1680 aagcagcuga aggaagacua cuucaagaag aucgaaugcu ucgacagcgu cgaaaucagc 1740 ggagucgaag acagauucaa cgcaagccug ggaacauacc acgaccugcu gaagaucauc 1800 aaggacaagg acuuccugga caacgaagaa aacgaagaca uccuggaaga caucguccug 1860 acacugacac uguucgaaga cagagaaaug aucgaagaaa gacugaagac auacgcacac 1920 cuguucgacg acaaggucau gaagcagcug aagagaagaa gauacacagg auggggaaga 1980 cugagcagaa agcugaucaa cggaaucaga gacaagcaga gcggaaagac aauccuggac 2040 uuccugaaga gcgacggauu cgcaaacaga aacuucaugc agcugaucca cgacgacagc 2100 cugacauuca aggaagacau ccagaaggca caggucagcg gacagggaga cagccugcac 2160 gaacacaucg caaaccuggc aggaagcccg gcaaucaaga agggaauccu gcagacaguc 2220 aaggucgucg acgaacuggu caaggucaug ggaagacaca agccggaaaa caucgucauc 2280 gaaauggcaa gagaaaacca gacaacacag aagggacaga agaacagcag agaaagaaug 2340 aagagaaucg aagaaggaau caaggaacug ggaagccaga uccugaagga acacccgguc 2400 gaaaacacac agcugcagaa cgaaaagcug uaccuguacu accugcagaa cggaagagac 2460 auguacgucg accaggaacu ggacaucaac agacugagcg acuacgacgu cgaccacauc 2520 gucccgcaga gcuuccugaa ggacgacagc aucgacaaca agguccugac aagaagcgac 2580 aagaacagag gaaagagcga caacgucccg agcgaagaag ucgucaagaa gaugaagaac 2640 uacuggagac agcugcugaa cgcaaagcug aucacacaga gaaaguucga caaccugaca 2700 aaggcagaga gaggaggacu gagcgaacug gacaaggcag gauucaucaa gagacagcug 2760 gucgaaacaa gacagaucac aaagcacguc gcacagaucc uggacagcag aaugaacaca 2820 aaguacgacg aaaacgacaa gcugaucaga gaagucaagg ucaucacacu gaagagcaag 2880 cuggucagcg acuucagaaa ggacuuccag uucuacaagg ucagagaaau caacaacuac 2940 caccacgcac acgacgcaua ccugaacgca gucgucggaa cagcacugau caagaaguac 3000 ccgaagcugg aaagcgaauu cgucuacgga gacuacaagg ucuacgacgu cagaaagaug 3060 aucgcaaaga gcgaacagga aaucggaaag gcaacagcaa aguacuucuu cuacagcaac 3120 aucaugaacu ucuucaagac agaaaucaca cuggcaaacg gagaaaucag aaagagaccg 3180 cugaucgaaa caaacggaga aacaggagaa aucgucuggg acaagggaag agacuucgca 3240 acagucagaa agguccugag caugccgcag gucaacaucg ucaagaagac agaaguccag 3300 acaggaggau ucagcaagga aagcauccug ccgaagagaa acagcgacaa gcugaucgca 3360 agaaagaagg acugggaccc gaagaaguac ggaggauucg acagcccgac agucgcauac 3420 agcguccugg ucgucgcaaa ggucgaaaag ggaaagagca agaagcugaa gagcgucaag 3480 gaacugcugg gaaucacaau cauggaaaga agcagcuucg aaaagaaccc gaucgacuuc 3540 cuggaagcaa agggauacaa ggaagucaag aaggaccuga ucaucaagcu gccgaaguac 3600 agccuguucg aacuggaaaa cggaagaaag agaaugcugg caagcgcagg agaacugcag 3660 aagggaaacg aacuggcacu gccgagcaag uacgucaacu uccuguaccu ggcaagccac 3720 uacgaaaagc ugaagggaag cccggaagac aacgaacaga agcagcuguu cgucgaacag 3780 cacaagcacu accuggacga aaucaucgaa cagaucagcg aauucagcaa gagagucauc 3840 cuggcagacg caaaccugga caagguccug agcgcauaca acaagcacag agacaagccg 3900 aucagagaac aggcagaaaa caucauccac cuguucacac ugacaaaccu gggagcaccg 3960 gcagcauuca aguacuucga cacaacaauc gacagaaaga gauacacaag cacaaaggaa 4020 guccuggacg caacacugau ccaccagagc aucacaggac uguacgaaac aagaaucgac 4080 cugagccagc ugggaggaga cggaagcgga agcccgaaga agaagagaaa ggucgacgga 4140 agcccgaaga agaagagaaa ggucgacagc gga 4173 <210> 25 <211> 1392 <212> PRT <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polipéptido sintético" <400> 25 Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 1 5 10 15 Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 20 25 30 Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 35 40 45 Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 65 70 75 80 Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 100 105 110 His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 115 120 125 His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 130 135 140 Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 145 150 155 160 Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 165 170 175 Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 180 185 190 Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 195 200 205 Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 210 215 220 Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 225 230 235 240 Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 245 250 255 Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 260 265 270 Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 275 280 285 Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 290 295 300 Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 325 330 335 Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 340 345 350 Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 355 360 365 Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 370 375 380 Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 385 390 395 400 Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 405 410 415 Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 420 425 430 Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 450 455 460 Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 465 470 475 480 Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 485 490 495 Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 530 535 540 Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 545 550 555 560 Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 565 570 575 Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 580 585 590 Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 595 600 605 Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 610 615 620 Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 625 630 635 640 His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 645 650 655 Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 660 665 670 Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 675 680 685 Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 690 695 700 Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 705 710 715 720 His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 725 730 735 Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 740 745 750 Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 755 760 765 Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 770 775 780 Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 805 810 815 Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 820 825 830 Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 835 840 845 Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 850 855 860 Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 865 870 875 880 Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 885 890 895 Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 900 905 910 Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 915 920 925 Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 930 935 940 Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 945 950 955 960 Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 965 970 975 Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 980 985 990 Val Gly Thr Ala Leu Ile Lys Lys Tyr Pro Lys Leu Glu Ser Glu Phe 995 1000 1005 Val Tyr Gly Asp Tyr Lys Val Tyr Asp Val Arg Lys Met Ile Ala 1010 1015 1020 Lys Ser Glu Gln Glu Ile Gly Lys Ala Thr Ala Lys Tyr Phe Phe 1025 1030 1035 Tyr Ser Asn Ile Met Asn Phe Phe Lys Thr Glu Ile Thr Leu Ala 1040 1045 1050 Asn Gly Glu Ile Arg Lys Arg Pro Leu Ile Glu Thr Asn Gly Glu 1055 1060 1065 Thr Gly Glu Ile Val Trp Asp Lys Gly Arg Asp Phe Ala Thr Val 1070 1075 1080 Arg Lys Val Leu Ser Met Pro Gln Val Asn Ile Val Lys Lys Thr 1085 1090 1095 Glu Val Gln Thr Gly Gly Phe Ser Lys Glu Ser Ile Leu Pro Lys 1100 1105 1110 Arg Asn Ser Asp Lys Leu Ile Ala Arg Lys Lys Asp Trp Asp Pro 1115 1120 1125 Lys Lys Tyr Gly Gly Phe Asp Ser Pro Thr Val Ala Tyr Ser Val 1130 1135 1140 Leu Val Val Ala Lys Val Glu Lys Gly Lys Ser Lys Lys Leu Lys 1145 1150 1155 Ser Val Lys Glu Leu Leu Gly Ile Thr Ile Met Glu Arg Ser Ser 1160 1165 1170 Phe Glu Lys Asn Pro Ile Asp Phe Leu Glu Ala Lys Gly Tyr Lys 1175 1180 1185 Glu Val Lys Lys Asp Leu Ile Ile Lys Leu Pro Lys Tyr Ser Leu 1190 1195 1200 Phe Glu Leu Glu Asn Gly Arg Lys Arg Met Leu Ala Ser Ala Gly 1205 1210 1215 Glu Leu Gln Lys Gly Asn Glu Leu Ala Leu Pro Ser Lys Tyr Val 1220 1225 1230 Asn Phe Leu Tyr Leu Ala Ser His Tyr Glu Lys Leu Lys Gly Ser 1235 1240 1245 Pro Glu Asp Asn Glu Gln Lys Gln Leu Phe Val Glu Gln His Lys 1250 1255 1260 His Tyr Leu Asp Glu Ile Ile Glu Gln Ile Ser Glu Phe Ser Lys 1265 1270 1275 Arg Val Ile Leu Ala Asp Ala Asn Leu Asp Lys Val Leu Ser Ala 1280 1285 1290 Tyr Asn Lys His Arg Asp Lys Pro Ile Arg Glu Gln Ala Glu Asn 1295 1300 1305 Ile Ile His Leu Phe Thr Leu Thr Asn Leu Gly Ala Pro Ala Ala 1310 1315 1320 Phe Lys Tyr Phe Asp Thr Thr Ile Asp Arg Lys Arg Tyr Thr Ser 1325 1330 1335 Thr Lys Glu Val Leu Asp Ala Thr Leu Ile His Gln Ser Ile Thr 1340 1345 1350 Gly Leu Tyr Glu Thr Arg Ile Asp Leu Ser Gln Leu Gly Gly Asp 1355 1360 1365 Gly Ser Gly Ser Pro Lys Lys Lys Arg Lys Val Asp Gly Ser Pro 1370 1375 1380 Lys Lys Lys Arg Lys Val Asp Ser Gly 1385 1390 <210> 26 <211> 4179 <212> ARN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 26 auggacaaga aguacagcau cggacuggca aucggaacaa acagcgucgg augggcaguc 60 aucacagacg aauacaaggu cccgagcaag aaguucaagg uccugggaaa cacagacaga 120 cacagcauca agaagaaccu gaucggagca cugcuguucg acagcggaga aacagcagaa 180 gcaacaagac ugaagagaac agcaagaaga agauacacaa gaagaaagaa cagaaucugc 240 uaccugcagg aaaucuucag caacgaaaug gcaaaggucg acgacagcuu cuuccacaga 300 cuggaagaaa gcuuccuggu cgaagaagac aagaagcacg aaagacaccc gaucuucgga 360 aacaucgucg acgaagucgc auaccacgaa aaguacccga caaucuacca ccugagaaag 420 aagcuggucg acagcacaga caaggcagac cugagacuga ucuaccuggc acuggcacac 480 augaucaagu ucagaggaca cuuccugauc gaaggagacc ugaacccgga caacagcgac 540 gucgacaagc uguucaucca gcugguccag acauacaacc agcuguucga agaaaacccg 600 aucaacgcaa gcggagucga cgcaaaggca auccugagcg caagacugag caagagcaga 660 agacuggaaa accugaucgc acagcugccg ggagaaaaga agaacggacu guucggaaac 720 cugaucgcac ugagccuggg acugacaccg aacuucaaga gcaacuucga ccuggcagaa 780 gacgcaaagc ugcagcugag caaggacaca uacgacgacg accuggacaa ccugcuggca 840 cagaucggag accaguacgc agaccuguuc cuggcagcaa agaaccugag cgacgcaauc 900 cugcugagcg acauccugag agucaacaca gaaaucacaa aggcaccgcu gagcgcaagc 960 augaucaaga gauacgacga acaccaccag gaccugacac ugcugaaggc acuggucaga 1020 cagcagcugc cggaaaagua caaggaaauc uucuucgacc agagcaagaa cggauacgca 1080 ggauacaucg acggaggagc aagccaggaa gaauucuaca aguucaucaa gccgauccug 1140 gaaaagaugg acggaacaga agaacugcug gucaagcuga acagagaaga ccugcugaga 1200 aagcagagaa cauucgacaa cggaagcauc ccgcaccaga uccaccuggg agaacugcac 1260 gcaauccuga gaagacagga agacuucuac ccguuccuga aggacaacag agaaaagauc 1320 gaaaagaucc ugacauucag aaucccguac uacgucggac cgcuggcaag aggaaacagc 1380 agauucgcau ggaugacaag aaagagcgaa gaaacaauca caccguggaa cuucgaagaa 1440 gucgucgaca agggagcaag cgcacagagc uucaucgaaa gaaugacaaa cuucgacaag 1500 aaccugccga acgaaaaggu ccugccgaag cacagccugc uguacgaaua cuucacaguc 1560 uacaacgaac ugacaaaggu caaguacguc acagaaggaa ugagaaagcc ggcauuccug 1620 agcggagaac agaagaaggc aaucgucgac cugcuguuca agacaaacag aaaggucaca 1680 gucaagcagc ugaaggaaga cuacuucaag aagaucgaau gcuucgacag cgucgaaauc 1740 agcggagucg aagacagauu caacgcaagc cugggaacau accacgaccu gcugaagauc 1800 aucaaggaca aggacuuccu ggacaacgaa gaaaacgaag acauccugga agacaucguc 1860 cugacacuga cacuguucga agacagagaa augaucgaag aaagacugaa gacauacgca 1920 caccuguucg acgacaaggu caugaagcag cugaagagaa gaagauacac aggaugggga 1980 agacugagca gaaagcugau caacggaauc agagacaagc agagcggaaa gacaauccug 2040 gacuuccuga agagcgacgg auucgcaaac agaaacuuca ugcagcugau ccacgacgac 2100 agccugacau ucaaggaaga cauccagaag gcacagguca gcggacaggg agacagccug 2160 cacgaacaca ucgcaaaccu ggcaggaagc ccggcaauca agaagggaau ccugcagaca 2220 gucaaggucg ucgacgaacu ggucaagguc augggaagac acaagccgga aaacaucguc 2280 aucgaaaugg caagagaaaa ccagacaaca cagaagggac agaagaacag cagagaaaga 2340 augaagagaa ucgaagaagg aaucaaggaa cugggaagcc agauccugaa ggaacacccg 2400 gucgaaaaca cacagcugca gaacgaaaag cuguaccugu acuaccugca gaacggaaga 2460 gacauguacg ucgaccagga acuggacauc aacagacuga gcgacuacga cgucgaccac 2520 aucgucccgc agagcuuccu gaaggacgac agcaucgaca acaagguccu gacaagaagc 2580 gacaagaaca gaggaaagag cgacaacguc ccgagcgaag aagucgucaa gaagaugaag 2640 aacuacugga gacagcugcu gaacgcaaag cugaucacac agagaaaguu cgacaaccug 2700 acaaaggcag agagaggagg acugagcgaa cuggacaagg caggauucau caagagacag 2760 cuggucgaaa caagacagau cacaaagcac gucgcacaga uccuggacag cagaaugaac 2820 acaaaguacg acgaaaacga caagcugauc agagaaguca aggucaucac acugaagagc 2880 aagcugguca gcgacuucag aaaggacuuc caguucuaca aggucagaga aaucaacaac 2940 uaccaccacg cacacgacgc auaccugaac gcagucgucg gaacagcacu gaucaagaag 3000 uacccgaagc uggaaagcga auucgucuac ggagacuaca aggucuacga cgucagaaag 3060 augaucgcaa agagcgaaca ggaaaucgga aaggcaacag caaaguacuu cuucuacagc 3120 aacaucauga acuucuucaa gacagaaauc acacuggcaa acggagaaau cagaaagaga 3180 ccgcugaucg aaacaaacgg agaaacagga gaaaucgucu gggacaaggg aagagacuuc 3240 gcaacaguca gaaagguccu gagcaugccg caggucaaca ucgucaagaa gacagaaguc 3300 cagacaggag gauucagcaa ggaaagcauc cugccgaaga gaaacagcga caagcugauc 3360 gcaagaaaga aggacuggga cccgaagaag uacggaggau ucgacagccc gacagucgca 3420 uacagcgucc uggucgucgc aaaggucgaa aagggaaaga gcaagaagcu gaagagcguc 3480 aaggaacugc ugggaaucac aaucauggaa agaagcagcu ucgaaaagaa cccgaucgac 3540 uuccuggaag caaagggaua caaggaaguc aagaaggacc ugaucaucaa gcugccgaag 3600 uacagccugu ucgaacugga aaacggaaga aagagaaugc uggcaagcgc aggagaacug 3660 cagaagggaa acgaacuggc acugccgagc aaguacguca acuuccugua ccuggcaagc 3720 cacuacgaaa agcugaaggg aagcccggaa gacaacgaac agaagcagcu guucgucgaa 3780 cagcacaagc acuaccugga cgaaaucauc gaacagauca gcgaauucag caagagaguc 3840 auccuggcag acgcaaaccu ggacaagguc cugagcgcau acaacaagca cagagacaag 3900 ccgaucagag aacaggcaga aaacaucauc caccuguuca cacugacaaa ccugggagca 3960 ccggcagcau ucaaguacuu cgacacaaca aucgacagaa agagauacac aagcacaaag 4020 gaaguccugg acgcaacacu gauccaccag agcaucacag gacuguacga aacaagaauc 4080 gaccugagcc agcugggagg agacggaagc ggaagcccga agaagaagag aaaggucgac 4140 ggaagcccga agaagaagag aaaggucgac agcggauag 4179 <210> 27 <211> 4173 <212> ARN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 27 gacaagaagu acagcaucgg acuggcaauc ggaacaaaca gcgucggaug ggcagucauc 60 acagacgaau acaagguccc gagcaagaag uucaaggucc ugggaaacac agacagacac 120 agcaucaaga agaaccugau cggagcacug cuguucgaca gcggagaaac agcagaagca 180 acaagacuga agagaacagc aagaagaaga uacacaagaa gaaagaacag aaucugcuac 240 cugcaggaaa ucuucagcaa cgaaauggca aaggucgacg acagcuucuu ccacagacug 300 gaagaaagcu uccuggucga agaagacaag aagcacgaaa gacacccgau cuucggaaac 360 aucgucgacg aagucgcaua ccacgaaaag uacccgacaa ucuaccaccu gagaaagaag 420 cuggucgaca gcacagacaa ggcagaccug agacugaucu accuggcacu ggcacacaug 480 aucaaguuca gaggacacuu ccugaucgaa ggagaccuga acccggacaa cagcgacguc 540 gacaagcugu ucauccagcu gguccagaca uacaaccagc uguucgaaga aaacccgauc 600 aacgcaagcg gagucgacgc aaaggcaauc cugagcgcaa gacugagcaa gagcagaaga 660 cuggaaaacc ugaucgcaca gcugccggga gaaaagaaga acggacuguu cggaaaccug 720 aucgcacuga gccugggacu gacaccgaac uucaagagca acuucgaccu ggcagaagac 780 gcaaagcugc agcugagcaa ggacacauac gacgacgacc uggacaaccu gcuggcacag 840 aucggagacc aguacgcaga ccuguuccug gcagcaaaga accugagcga cgcaauccug 900 cugagcgaca uccugagagu caacacagaa aucacaaagg caccgcugag cgcaagcaug 960 aucaagagau acgacgaaca ccaccaggac cugacacugc ugaaggcacu ggucagacag 1020 cagcugccgg aaaaguacaa ggaaaucuuc uucgaccaga gcaagaacgg auacgcagga 1080 uacaucgacg gaggagcaag ccaggaagaa uucuacaagu ucaucaagcc gauccuggaa 1140 aagauggacg gaacagaaga acugcugguc aagcugaaca gagaagaccu gcugagaaag 1200 cagagaacau ucgacaacgg aagcaucccg caccagaucc accugggaga acugcacgca 1260 auccugagaa gacaggaaga cuucuacccg uuccugaagg acaacagaga aaagaucgaa 1320 aagauccuga cauucagaau cccguacuac gucggaccgc uggcaagagg aaacagcaga 1380 uucgcaugga ugacaagaaa gagcgaagaa acaaucacac cguggaacuu cgaagaaguc 1440 gucgacaagg gagcaagcgc acagagcuuc aucgaaagaa ugacaaacuu cgacaagaac 1500 cugccgaacg aaaagguccu gccgaagcac agccugcugu acgaauacuu cacagucuac 1560 aacgaacuga caaaggucaa guacgucaca gaaggaauga gaaagccggc auuccugagc 1620 ggagaacaga agaaggcaau cgucgaccug cuguucaaga caaacagaaa ggucacaguc 1680 aagcagcuga aggaagacua cuucaagaag aucgaaugcu ucgacagcgu cgaaaucagc 1740 ggagucgaag acagauucaa cgcaagccug ggaacauacc acgaccugcu gaagaucauc 1800 aaggacaagg acuuccugga caacgaagaa aacgaagaca uccuggaaga caucguccug 1860 acacugacac uguucgaaga cagagaaaug aucgaagaaa gacugaagac auacgcacac 1920 cuguucgacg acaaggucau gaagcagcug aagagaagaa gauacacagg auggggaaga 1980 cugagcagaa agcugaucaa cggaaucaga gacaagcaga gcggaaagac aauccuggac 2040 uuccugaaga gcgacggauu cgcaaacaga aacuucaugc agcugaucca cgacgacagc 2100 cugacauuca aggaagacau ccagaaggca caggucagcg gacagggaga cagccugcac 2160 gaacacaucg caaaccuggc aggaagcccg gcaaucaaga agggaauccu gcagacaguc 2220 aaggucgucg acgaacuggu caaggucaug ggaagacaca agccggaaaa caucgucauc 2280 gaaauggcaa gagaaaacca gacaacacag aagggacaga agaacagcag agaaagaaug 2340 aagagaaucg aagaaggaau caaggaacug ggaagccaga uccugaagga acacccgguc 2400 gaaaacacac agcugcagaa cgaaaagcug uaccuguacu accugcagaa cggaagagac 2460 auguacgucg accaggaacu ggacaucaac agacugagcg acuacgacgu cgaccacauc 2520 gucccgcaga gcuuccugaa ggacgacagc aucgacaaca agguccugac aagaagcgac 2580 aagaacagag gaaagagcga caacgucccg agcgaagaag ucgucaagaa gaugaagaac 2640 uacuggagac agcugcugaa cgcaaagcug aucacacaga gaaaguucga caaccugaca 2700 aaggcagaga gaggaggacu gagcgaacug gacaaggcag gauucaucaa gagacagcug 2760 gucgaaacaa gacagaucac aaagcacguc gcacagaucc uggacagcag aaugaacaca 2820 aaguacgacg aaaacgacaa gcugaucaga gaagucaagg ucaucacacu gaagagcaag 2880 cuggucagcg acuucagaaa ggacuuccag uucuacaagg ucagagaaau caacaacuac 2940 caccacgcac acgacgcaua ccugaacgca gucgucggaa cagcacugau caagaaguac 3000 ccgaagcugg aaagcgaauu cgucuacgga gacuacaagg ucuacgacgu cagaaagaug 3060 aucgcaaaga gcgaacagga aaucggaaag gcaacagcaa aguacuucuu cuacagcaac 3120 aucaugaacu ucuucaagac agaaaucaca cuggcaaacg gagaaaucag aaagagaccg 3180 cugaucgaaa caaacggaga aacaggagaa aucgucuggg acaagggaag agacuucgca 3240 acagucagaa agguccugag caugccgcag gucaacaucg ucaagaagac agaaguccag 3300 acaggaggau ucagcaagga aagcauccug ccgaagagaa acagcgacaa gcugaucgca 3360 agaaagaagg acugggaccc gaagaaguac ggaggauucg acagcccgac agucgcauac 3420 agcguccugg ucgucgcaaa ggucgaaaag ggaaagagca agaagcugaa gagcgucaag 3480 gaacugcugg gaaucacaau cauggaaaga agcagcuucg aaaagaaccc gaucgacuuc 3540 cuggaagcaa agggauacaa ggaagucaag aaggaccuga ucaucaagcu gccgaaguac 3600 agccuguucg aacuggaaaa cggaagaaag agaaugcugg caagcgcagg agaacugcag 3660 aagggaaacg aacuggcacu gccgagcaag uacgucaacu uccuguaccu ggcaagccac 3720 uacgaaaagc ugaagggaag cccggaagac aacgaacaga agcagcuguu cgucgaacag 3780 cacaagcacu accuggacga aaucaucgaa cagaucagcg aauucagcaa gagagucauc 3840 cuggcagacg caaaccugga caagguccug agcgcauaca acaagcacag agacaagccg 3900 aucagagaac aggcagaaaa caucauccac cuguucacac ugacaaaccu gggagcaccg 3960 gcagcauuca aguacuucga cacaacaauc gacagaaaga gauacacaag cacaaaggaa 4020 guccuggacg caacacugau ccaccagagc aucacaggac uguacgaaac aagaaucgac 4080 cugagccagc ugggaggaga cggaagcgga agcccgaaga agaagagaaa ggucgacgga 4140 agcccgaaga agaagagaaa ggucgacagc gga 4173 <210> 28 <211> 1392 <212> PRT <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polipéptido sintético" <400> 28 Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 1 5 10 15 Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 20 25 30 Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 35 40 45 Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 65 70 75 80 Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 100 105 110 His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 115 120 125 His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 130 135 140 Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 145 150 155 160 Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 165 170 175 Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 180 185 190 Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 195 200 205 Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 210 215 220 Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 225 230 235 240 Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 245 250 255 Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 260 265 270 Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 275 280 285 Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 290 295 300 Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 325 330 335 Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 340 345 350 Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 355 360 365 Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 370 375 380 Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 385 390 395 400 Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 405 410 415 Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 420 425 430 Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 450 455 460 Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 465 470 475 480 Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 485 490 495 Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 530 535 540 Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 545 550 555 560 Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 565 570 575 Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 580 585 590 Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 595 600 605 Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 610 615 620 Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 625 630 635 640 His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 645 650 655 Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 660 665 670 Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 675 680 685 Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 690 695 700 Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 705 710 715 720 His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 725 730 735 Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 740 745 750 Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 755 760 765 Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 770 775 780 Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 805 810 815 Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 820 825 830 Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys 835 840 845 Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 850 855 860 Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 865 870 875 880 Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 885 890 895 Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 900 905 910 Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 915 920 925 Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 930 935 940 Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 945 950 955 960 Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 965 970 975 Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 980 985 990 Val Gly Thr Ala Leu Ile Lys Lys Tyr Pro Lys Leu Glu Ser Glu Phe 995 1000 1005 Val Tyr Gly Asp Tyr Lys Val Tyr Asp Val Arg Lys Met Ile Ala 1010 1015 1020 Lys Ser Glu Gln Glu Ile Gly Lys Ala Thr Ala Lys Tyr Phe Phe 1025 1030 1035 Tyr Ser Asn Ile Met Asn Phe Phe Lys Thr Glu Ile Thr Leu Ala 1040 1045 1050 Asn Gly Glu Ile Arg Lys Arg Pro Leu Ile Glu Thr Asn Gly Glu 1055 1060 1065 Thr Gly Glu Ile Val Trp Asp Lys Gly Arg Asp Phe Ala Thr Val 1070 1075 1080 Arg Lys Val Leu Ser Met Pro Gln Val Asn Ile Val Lys Lys Thr 1085 1090 1095 Glu Val Gln Thr Gly Gly Phe Ser Lys Glu Ser Ile Leu Pro Lys 1100 1105 1110 Arg Asn Ser Asp Lys Leu Ile Ala Arg Lys Lys Asp Trp Asp Pro 1115 1120 1125 Lys Lys Tyr Gly Gly Phe Asp Ser Pro Thr Val Ala Tyr Ser Val 1130 1135 1140 Leu Val Val Ala Lys Val Glu Lys Gly Lys Ser Lys Lys Leu Lys 1145 1150 1155 Ser Val Lys Glu Leu Leu Gly Ile Thr Ile Met Glu Arg Ser Ser 1160 1165 1170 Phe Glu Lys Asn Pro Ile Asp Phe Leu Glu Ala Lys Gly Tyr Lys 1175 1180 1185 Glu Val Lys Lys Asp Leu Ile Ile Lys Leu Pro Lys Tyr Ser Leu 1190 1195 1200 Phe Glu Leu Glu Asn Gly Arg Lys Arg Met Leu Ala Ser Ala Gly 1205 1210 1215 Glu Leu Gln Lys Gly Asn Glu Leu Ala Leu Pro Ser Lys Tyr Val 1220 1225 1230 Asn Phe Leu Tyr Leu Ala Ser His Tyr Glu Lys Leu Lys Gly Ser 1235 1240 1245 Pro Glu Asp Asn Glu Gln Lys Gln Leu Phe Val Glu Gln His Lys 1250 1255 1260 His Tyr Leu Asp Glu Ile Ile Glu Gln Ile Ser Glu Phe Ser Lys 1265 1270 1275 Arg Val Ile Leu Ala Asp Ala Asn Leu Asp Lys Val Leu Ser Ala 1280 1285 1290 Tyr Asn Lys His Arg Asp Lys Pro Ile Arg Glu Gln Ala Glu Asn 1295 1300 1305 Ile Ile His Leu Phe Thr Leu Thr Asn Leu Gly Ala Pro Ala Ala 1310 1315 1320 Phe Lys Tyr Phe Asp Thr Thr Ile Asp Arg Lys Arg Tyr Thr Ser 1325 1330 1335 Thr Lys Glu Val Leu Asp Ala Thr Leu Ile His Gln Ser Ile Thr 1340 1345 1350 Gly Leu Tyr Glu Thr Arg Ile Asp Leu Ser Gln Leu Gly Gly Asp 1355 1360 1365 Gly Ser Gly Ser Pro Lys Lys Lys Arg Lys Val Asp Gly Ser Pro 1370 1375 1380 Lys Lys Lys Arg Lys Val Asp Ser Gly 1385 1390 <210> 29 <211> 4179 <212> ARN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 29 auggacaaga aguacagcau cggacuggca aucggaacaa acagcgucgg augggcaguc 60 aucacagacg aauacaaggu cccgagcaag aaguucaagg uccugggaaa cacagacaga 120 cacagcauca agaagaaccu gaucggagca cugcuguucg acagcggaga aacagcagaa 180 gcaacaagac ugaagagaac agcaagaaga agauacacaa gaagaaagaa cagaaucugc 240 uaccugcagg aaaucuucag caacgaaaug gcaaaggucg acgacagcuu cuuccacaga 300 cuggaagaaa gcuuccuggu cgaagaagac aagaagcacg aaagacaccc gaucuucgga 360 aacaucgucg acgaagucgc auaccacgaa aaguacccga caaucuacca ccugagaaag 420 aagcuggucg acagcacaga caaggcagac cugagacuga ucuaccuggc acuggcacac 480 augaucaagu ucagaggaca cuuccugauc gaaggagacc ugaacccgga caacagcgac 540 gucgacaagc uguucaucca gcugguccag acauacaacc agcuguucga agaaaacccg 600 aucaacgcaa gcggagucga cgcaaaggca auccugagcg caagacugag caagagcaga 660 agacuggaaa accugaucgc acagcugccg ggagaaaaga agaacggacu guucggaaac 720 cugaucgcac ugagccuggg acugacaccg aacuucaaga gcaacuucga ccuggcagaa 780 gacgcaaagc ugcagcugag caaggacaca uacgacgacg accuggacaa ccugcuggca 840 cagaucggag accaguacgc agaccuguuc cuggcagcaa agaaccugag cgacgcaauc 900 cugcugagcg acauccugag agucaacaca gaaaucacaa aggcaccgcu gagcgcaagc 960 augaucaaga gauacgacga acaccaccag gaccugacac ugcugaaggc acuggucaga 1020 cagcagcugc cggaaaagua caaggaaauc uucuucgacc agagcaagaa cggauacgca 1080 ggauacaucg acggaggagc aagccaggaa gaauucuaca aguucaucaa gccgauccug 1140 gaaaagaugg acggaacaga agaacugcug gucaagcuga acagagaaga ccugcugaga 1200 aagcagagaa cauucgacaa cggaagcauc ccgcaccaga uccaccuggg agaacugcac 1260 gcaauccuga gaagacagga agacuucuac ccguuccuga aggacaacag agaaaagauc 1320 gaaaagaucc ugacauucag aaucccguac uacgucggac cgcuggcaag aggaaacagc 1380 agauucgcau ggaugacaag aaagagcgaa gaaacaauca caccguggaa cuucgaagaa 1440 gucgucgaca agggagcaag cgcacagagc uucaucgaaa gaaugacaaa cuucgacaag 1500 aaccugccga acgaaaaggu ccugccgaag cacagccugc uguacgaaua cuucacaguc 1560 uacaacgaac ugacaaaggu caaguacguc acagaaggaa ugagaaagcc ggcauuccug 1620 agcggagaac agaagaaggc aaucgucgac cugcuguuca agacaaacag aaaggucaca 1680 gucaagcagc ugaaggaaga cuacuucaag aagaucgaau gcuucgacag cgucgaaauc 1740 agcggagucg aagacagauu caacgcaagc cugggaacau accacgaccu gcugaagauc 1800 aucaaggaca aggacuuccu ggacaacgaa gaaaacgaag acauccugga agacaucguc 1860 cugacacuga cacuguucga agacagagaa augaucgaag aaagacugaa gacauacgca 1920 caccuguucg acgacaaggu caugaagcag cugaagagaa gaagauacac aggaugggga 1980 agacugagca gaaagcugau caacggaauc agagacaagc agagcggaaa gacaauccug 2040 gacuuccuga agagcgacgg auucgcaaac agaaacuuca ugcagcugau ccacgacgac 2100 agccugacau ucaaggaaga cauccagaag gcacagguca gcggacaggg agacagccug 2160 cacgaacaca ucgcaaaccu ggcaggaagc ccggcaauca agaagggaau ccugcagaca 2220 gucaaggucg ucgacgaacu ggucaagguc augggaagac acaagccgga aaacaucguc 2280 aucgaaaugg caagagaaaa ccagacaaca cagaagggac agaagaacag cagagaaaga 2340 augaagagaa ucgaagaagg aaucaaggaa cugggaagcc agauccugaa ggaacacccg 2400 gucgaaaaca cacagcugca gaacgaaaag cuguaccugu acuaccugca gaacggaaga 2460 gacauguacg ucgaccagga acuggacauc aacagacuga gcgacuacga cgucgacgca 2520 aucgucccgc agagcuuccu gaaggacgac agcaucgaca acaagguccu gacaagaagc 2580 gacaagaaca gaggaaagag cgacaacguc ccgagcgaag aagucgucaa gaagaugaag 2640 aacuacugga gacagcugcu gaacgcaaag cugaucacac agagaaaguu cgacaaccug 2700 acaaaggcag agagaggagg acugagcgaa cuggacaagg caggauucau caagagacag 2760 cuggucgaaa caagacagau cacaaagcac gucgcacaga uccuggacag cagaaugaac 2820 acaaaguacg acgaaaacga caagcugauc agagaaguca aggucaucac acugaagagc 2880 aagcugguca gcgacuucag aaaggacuuc caguucuaca aggucagaga aaucaacaac 2940 uaccaccacg cacacgacgc auaccugaac gcagucgucg gaacagcacu gaucaagaag 3000 uacccgaagc uggaaagcga auucgucuac ggagacuaca aggucuacga cgucagaaag 3060 augaucgcaa agagcgaaca ggaaaucgga aaggcaacag caaaguacuu cuucuacagc 3120 aacaucauga acuucuucaa gacagaaauc acacuggcaa acggagaaau cagaaagaga 3180 ccgcugaucg aaacaaacgg agaaacagga gaaaucgucu gggacaaggg aagagacuuc 3240 gcaacaguca gaaagguccu gagcaugccg caggucaaca ucgucaagaa gacagaaguc 3300 cagacaggag gauucagcaa ggaaagcauc cugccgaaga gaaacagcga caagcugauc 3360 gcaagaaaga aggacuggga cccgaagaag uacggaggau ucgacagccc gacagucgca 3420 uacagcgucc uggucgucgc aaaggucgaa aagggaaaga gcaagaagcu gaagagcguc 3480 aaggaacugc ugggaaucac aaucauggaa agaagcagcu ucgaaaagaa cccgaucgac 3540 uuccuggaag caaagggaua caaggaaguc aagaaggacc ugaucaucaa gcugccgaag 3600 uacagccugu ucgaacugga aaacggaaga aagagaaugc uggcaagcgc aggagaacug 3660 cagaagggaa acgaacuggc acugccgagc aaguacguca acuuccugua ccuggcaagc 3720 cacuacgaaa agcugaaggg aagcccggaa gacaacgaac agaagcagcu guucgucgaa 3780 cagcacaagc acuaccugga cgaaaucauc gaacagauca gcgaauucag caagagaguc 3840 auccuggcag acgcaaaccu ggacaagguc cugagcgcau acaacaagca cagagacaag 3900 ccgaucagag aacaggcaga aaacaucauc caccuguuca cacugacaaa ccugggagca 3960 ccggcagcau ucaaguacuu cgacacaaca aucgacagaa agagauacac aagcacaaag 4020 gaaguccugg acgcaacacu gauccaccag agcaucacag gacuguacga aacaagaauc 4080 gaccugagcc agcugggagg agacggaagc ggaagcccga agaagaagag aaaggucgac 4140 ggaagcccga agaagaagag aaaggucgac agcggauag 4179 <210> 30 <211> 4173 <212> ARN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 30 gacaagaagu acagcaucgg acuggcaauc ggaacaaaca gcgucggaug ggcagucauc 60 acagacgaau acaagguccc gagcaagaag uucaaggucc ugggaaacac agacagacac 120 agcaucaaga agaaccugau cggagcacug cuguucgaca gcggagaaac agcagaagca 180 acaagacuga agagaacagc aagaagaaga uacacaagaa gaaagaacag aaucugcuac 240 cugcaggaaa ucuucagcaa cgaaauggca aaggucgacg acagcuucuu ccacagacug 300 gaagaaagcu uccuggucga agaagacaag aagcacgaaa gacacccgau cuucggaaac 360 aucgucgacg aagucgcaua ccacgaaaag uacccgacaa ucuaccaccu gagaaagaag 420 cuggucgaca gcacagacaa ggcagaccug agacugaucu accuggcacu ggcacacaug 480 aucaaguuca gaggacacuu ccugaucgaa ggagaccuga acccggacaa cagcgacguc 540 gacaagcugu ucauccagcu gguccagaca uacaaccagc uguucgaaga aaacccgauc 600 aacgcaagcg gagucgacgc aaaggcaauc cugagcgcaa gacugagcaa gagcagaaga 660 cuggaaaacc ugaucgcaca gcugccggga gaaaagaaga acggacuguu cggaaaccug 720 aucgcacuga gccugggacu gacaccgaac uucaagagca acuucgaccu ggcagaagac 780 gcaaagcugc agcugagcaa ggacacauac gacgacgacc uggacaaccu gcuggcacag 840 aucggagacc aguacgcaga ccuguuccug gcagcaaaga accugagcga cgcaauccug 900 cugagcgaca uccugagagu caacacagaa aucacaaagg caccgcugag cgcaagcaug 960 aucaagagau acgacgaaca ccaccaggac cugacacugc ugaaggcacu ggucagacag 1020 cagcugccgg aaaaguacaa ggaaaucuuc uucgaccaga gcaagaacgg auacgcagga 1080 uacaucgacg gaggagcaag ccaggaagaa uucuacaagu ucaucaagcc gauccuggaa 1140 aagauggacg gaacagaaga acugcugguc aagcugaaca gagaagaccu gcugagaaag 1200 cagagaacau ucgacaacgg aagcaucccg caccagaucc accugggaga acugcacgca 1260 auccugagaa gacaggaaga cuucuacccg uuccugaagg acaacagaga aaagaucgaa 1320 aagauccuga cauucagaau cccguacuac gucggaccgc uggcaagagg aaacagcaga 1380 uucgcaugga ugacaagaaa gagcgaagaa acaaucacac cguggaacuu cgaagaaguc 1440 gucgacaagg gagcaagcgc acagagcuuc aucgaaagaa ugacaaacuu cgacaagaac 1500 cugccgaacg aaaagguccu gccgaagcac agccugcugu acgaauacuu cacagucuac 1560 aacgaacuga caaaggucaa guacgucaca gaaggaauga gaaagccggc auuccugagc 1620 ggagaacaga agaaggcaau cgucgaccug cuguucaaga caaacagaaa ggucacaguc 1680 aagcagcuga aggaagacua cuucaagaag aucgaaugcu ucgacagcgu cgaaaucagc 1740 ggagucgaag acagauucaa cgcaagccug ggaacauacc acgaccugcu gaagaucauc 1800 aaggacaagg acuuccugga caacgaagaa aacgaagaca uccuggaaga caucguccug 1860 acacugacac uguucgaaga cagagaaaug aucgaagaaa gacugaagac auacgcacac 1920 cuguucgacg acaaggucau gaagcagcug aagagaagaa gauacacagg auggggaaga 1980 cugagcagaa agcugaucaa cggaaucaga gacaagcaga gcggaaagac aauccuggac 2040 uuccugaaga gcgacggauu cgcaaacaga aacuucaugc agcugaucca cgacgacagc 2100 cugacauuca aggaagacau ccagaaggca caggucagcg gacagggaga cagccugcac 2160 gaacacaucg caaaccuggc aggaagcccg gcaaucaaga agggaauccu gcagacaguc 2220 aaggucgucg acgaacuggu caaggucaug ggaagacaca agccggaaaa caucgucauc 2280 gaaauggcaa gagaaaacca gacaacacag aagggacaga agaacagcag agaaagaaug 2340 aagagaaucg aagaaggaau caaggaacug ggaagccaga uccugaagga acacccgguc 2400 gaaaacacac agcugcagaa cgaaaagcug uaccuguacu accugcagaa cggaagagac 2460 auguacgucg accaggaacu ggacaucaac agacugagcg acuacgacgu cgacgcaauc 2520 gucccgcaga gcuuccugaa ggacgacagc aucgacaaca agguccugac aagaagcgac 2580 aagaacagag gaaagagcga caacgucccg agcgaagaag ucgucaagaa gaugaagaac 2640 uacuggagac agcugcugaa cgcaaagcug aucacacaga gaaaguucga caaccugaca 2700 aaggcagaga gaggaggacu gagcgaacug gacaaggcag gauucaucaa gagacagcug 2760 gucgaaacaa gacagaucac aaagcacguc gcacagaucc uggacagcag aaugaacaca 2820 aaguacgacg aaaacgacaa gcugaucaga gaagucaagg ucaucacacu gaagagcaag 2880 cuggucagcg acuucagaaa ggacuuccag uucuacaagg ucagagaaau caacaacuac 2940 caccacgcac acgacgcaua ccugaacgca gucgucggaa cagcacugau caagaaguac 3000 ccgaagcugg aaagcgaauu cgucuacgga gacuacaagg ucuacgacgu cagaaagaug 3060 aucgcaaaga gcgaacagga aaucggaaag gcaacagcaa aguacuucuu cuacagcaac 3120 aucaugaacu ucuucaagac agaaaucaca cuggcaaacg gagaaaucag aaagagaccg 3180 cugaucgaaa caaacggaga aacaggagaa aucgucuggg acaagggaag agacuucgca 3240 acagucagaa agguccugag caugccgcag gucaacaucg ucaagaagac agaaguccag 3300 acaggaggau ucagcaagga aagcauccug ccgaagagaa acagcgacaa gcugaucgca 3360 agaaagaagg acugggaccc gaagaaguac ggaggauucg acagcccgac agucgcauac 3420 agcguccugg ucgucgcaaa ggucgaaaag ggaaagagca agaagcugaa gagcgucaag 3480 gaacugcugg gaaucacaau cauggaaaga agcagcuucg aaaagaaccc gaucgacuuc 3540 cuggaagcaa agggauacaa ggaagucaag aaggaccuga ucaucaagcu gccgaaguac 3600 agccuguucg aacuggaaaa cggaagaaag agaaugcugg caagcgcagg agaacugcag 3660 aagggaaacg aacuggcacu gccgagcaag uacgucaacu uccuguaccu ggcaagccac 3720 uacgaaaagc ugaagggaag cccggaagac aacgaacaga agcagcuguu cgucgaacag 3780 cacaagcacu accuggacga aaucaucgaa cagaucagcg aauucagcaa gagagucauc 3840 cuggcagacg caaaccugga caagguccug agcgcauaca acaagcacag agacaagccg 3900 aucagagaac aggcagaaaa caucauccac cuguucacac ugacaaaccu gggagcaccg 3960 gcagcauuca aguacuucga cacaacaauc gacagaaaga gauacacaag cacaaaggaa 4020 guccuggacg caacacugau ccaccagagc aucacaggac uguacgaaac aagaaucgac 4080 cugagccagc ugggaggaga cggaagcgga agcccgaaga agaagagaaa ggucgacgga 4140 agcccgaaga agaagagaaa ggucgacagc gga 4173 <210> 31 <211> 17 <212> ADN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Oligonucleótido sintético" <400> 31 taatacgact cactata 17 <210> 32 <211> 50 <212> ADN <213> Homo sapiens <400> 32 acatttgctt ctgacacaac tgtgttcact agcaacctca aacagacacc 50 <210> 33 <211> 132 <212> ADN <213> Homo sapiens <400> 33 gctcgctttc ttgctgtcca atttctatta aaggttcctt tgttccctaa gtccaactac 60 taaactgggg gatattatga agggccttga gcatctggat tctgcctaat aaaaaacatt 120 tattttcatt gc 132 <210> 34 <211> 66 <212> ADN <213> Homo sapiens <400> 34 cataaaccct ggcgcgctcg cggcccggca ctcttctggt ccccacagac tcagagagaa 60 cccacc 66 <210> 35 <211> 110 <212> ADN <213> Homo sapiens <400> 35 gctggagcct cggtggccat gcttcttgcc ccttgggcct ccccccagcc cctcctcccc 60 ttcctgcacc cgtacccccg tggtctttga ataaagtctg agtgggcggc 110 <210> 36 <211> 29 <212> ADN <213> Xenopus laevis <400> 36 aagctcagaa taaacgctca actttggcc 29 <210> 37 <211> 130 <212> ADN <213> Xenopus laevis <400> 37 accagcctca agaacacccg aatggagtct ctaagctaca taataccaac ttacacttta 60 caaaatgttg tcccccaaaa tgtagccatt cgtatctgct cctaataaaa agaaagtttc 120 ttcacattct 130 <210> 38 <211> 27 <212> ADN <213> Bos sp. <400> 38 cagggtcctg tggacagctc accagct 27 <210> 39 <211> 102 <212> ADN <213> Bos sp. <400> 39 ttgccagcca tctgttgttt gcccctcccc cgtgccttcc ttgaccctgg aaggtgccac 60 tcccactgtc ctttcctaat aaaatgagga aattgcatcg ca 102 <210> 40 <211> 93 <212> ADN <213> Mus musculus <400> 40 gctgccttct gcggggcttg ccttctggcc atgcccttct tctctccctt gcacctgtac 60 ctcttggtct ttgaataaag cctgagtagg aag 93 <210> 41 <211> 61 <212> ADN <213> Desconocido <220> <221> fuente <223> /nota="Descripción de desconocido: Secuencia UTR 5’ de HSD17B4" <400> 41 tcccgcagtc ggcgtccagc ggctctgctt gttcgtgtgt gtgtcgttgc aggccttatt 60 c 61 <210> 42 <211> 100 <212> ARN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <220> <221> modified_base <222> (1)..(3) <223> Modificada 2’-O-metilo <220> <221> misc_feature <222> (1)..(4) <223> Enlace fosforotiotato <220> <221> modified_base <222> (29)..(40) <223> Modificada 2’-O-metilo <220> <221> modified_base <222> (69)..(100) <223> Modificada 2’-O-metilo <220> <221> misc_feature <222> (97)..(100) <223> Enlace fosforotiotato <400> 42 uuacagccac gucuacagca guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc 60 cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu 100 <210> 43 <211> 4411 <212> ADN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 43 gggtcccgca gtcggcgtcc agcggctctg cttgttcgtg tgtgtgtcgt tgcaggcctt 60 attcggatcc gccaccatgg acaagaagta cagcatcgga ctggacatcg gaacaaacag 120 cgtcggatgg gcagtcatca cagacgaata caaggtcccg agcaagaagt tcaaggtcct 180 gggaaacaca gacagacaca gcatcaagaa gaacctgatc ggagcactgc tgttcgacag 240 cggagaaaca gcagaagcaa caagactgaa gagaacagca agaagaagat acacaagaag 300 aaagaacaga atctgctacc tgcaggaaat cttcagcaac gaaatggcaa aggtcgacga 360 cagcttcttc cacagactgg aagaaagctt cctggtcgaa gaagacaaga agcacgaaag 420 acacccgatc ttcggaaaca tcgtcgacga agtcgcatac cacgaaaagt acccgacaat 480 ctaccacctg agaaagaagc tggtcgacag cacagacaag gcagacctga gactgatcta 540 cctggcactg gcacacatga tcaagttcag aggacacttc ctgatcgaag gagacctgaa 600 cccggacaac agcgacgtcg acaagctgtt catccagctg gtccagacat acaaccagct 660 gttcgaagaa aacccgatca acgcaagcgg agtcgacgca aaggcaatcc tgagcgcaag 720 actgagcaag agcagaagac tggaaaacct gatcgcacag ctgccgggag aaaagaagaa 780 cggactgttc ggaaacctga tcgcactgag cctgggactg acaccgaact tcaagagcaa 840 cttcgacctg gcagaagacg caaagctgca gctgagcaag gacacatacg acgacgacct 900 ggacaacctg ctggcacaga tcggagacca gtacgcagac ctgttcctgg cagcaaagaa 960 cctgagcgac gcaatcctgc tgagcgacat cctgagagtc aacacagaaa tcacaaaggc 1020 accgctgagc gcaagcatga tcaagagata cgacgaacac caccaggacc tgacactgct 1080 gaaggcactg gtcagacagc agctgccgga aaagtacaag gaaatcttct tcgaccagag 1140 caagaacgga tacgcaggat acatcgacgg aggagcaagc caggaagaat tctacaagtt 1200 catcaagccg atcctggaaa agatggacgg aacagaagaa ctgctggtca agctgaacag 1260 agaagacctg ctgagaaagc agagaacatt cgacaacgga agcatcccgc accagatcca 1320 cctgggagaa ctgcacgcaa tcctgagaag acaggaagac ttctacccgt tcctgaagga 1380 caacagagaa aagatcgaaa agatcctgac attcagaatc ccgtactacg tcggaccgct 1440 ggcaagagga aacagcagat tcgcatggat gacaagaaag agcgaagaaa caatcacacc 1500 gtggaacttc gaagaagtcg tcgacaaggg agcaagcgca cagagcttca tcgaaagaat 1560 gacaaacttc gacaagaacc tgccgaacga aaaggtcctg ccgaagcaca gcctgctgta 1620 cgaatacttc acagtctaca acgaactgac aaaggtcaag tacgtcacag aaggaatgag 1680 aaagccggca ttcctgagcg gagaacagaa gaaggcaatc gtcgacctgc tgttcaagac 1740 aaacagaaag gtcacagtca agcagctgaa ggaagactac ttcaagaaga tcgaatgctt 1800 cgacagcgtc gaaatcagcg gagtcgaaga cagattcaac gcaagcctgg gaacatacca 1860 cgacctgctg aagatcatca aggacaagga cttcctggac aacgaagaaa acgaagacat 1920 cctggaagac atcgtcctga cactgacact gttcgaagac agagaaatga tcgaagaaag 1980 actgaagaca tacgcacacc tgttcgacga caaggtcatg aagcagctga agagaagaag 2040 atacacagga tggggaagac tgagcagaaa gctgatcaac ggaatcagag acaagcagag 2100 cggaaagaca atcctggact tcctgaagag cgacggattc gcaaacagaa acttcatgca 2160 gctgatccac gacgacagcc tgacattcaa ggaagacatc cagaaggcac aggtcagcgg 2220 acagggagac agcctgcacg aacacatcgc aaacctggca ggaagcccgg caatcaagaa 2280 gggaatcctg cagacagtca aggtcgtcga cgaactggtc aaggtcatgg gaagacacaa 2340 gccggaaaac atcgtcatcg aaatggcaag agaaaaccag acaacacaga agggacagaa 2400 gaacagcaga gaaagaatga agagaatcga agaaggaatc aaggaactgg gaagccagat 2460 cctgaaggaa cacccggtcg aaaacacaca gctgcagaac gaaaagctgt acctgtacta 2520 cctgcagaac ggaagagaca tgtacgtcga ccaggaactg gacatcaaca gactgagcga 2580 ctacgacgtc gaccacatcg tcccgcagag cttcctgaag gacgacagca tcgacaacaa 2640 ggtcctgaca agaagcgaca agaacagagg aaagagcgac aacgtcccga gcgaagaagt 2700 cgtcaagaag atgaagaact actggagaca gctgctgaac gcaaagctga tcacacagag 2760 aaagttcgac aacctgacaa aggcagagag aggaggactg agcgaactgg acaaggcagg 2820 attcatcaag agacagctgg tcgaaacaag acagatcaca aagcacgtcg cacagatcct 2880 ggacagcaga atgaacacaa agtacgacga aaacgacaag ctgatcagag aagtcaaggt 2940 catcacactg aagagcaagc tggtcagcga cttcagaaag gacttccagt tctacaaggt 3000 cagagaaatc aacaactacc accacgcaca cgacgcatac ctgaacgcag tcgtcggaac 3060 agcactgatc aagaagtacc cgaagctgga aagcgaattc gtctacggag actacaaggt 3120 ctacgacgtc agaaagatga tcgcaaagag cgaacaggaa atcggaaagg caacagcaaa 3180 gtacttcttc tacagcaaca tcatgaactt cttcaagaca gaaatcacac tggcaaacgg 3240 agaaatcaga aagagaccgc tgatcgaaac aaacggagaa acaggagaaa tcgtctggga 3300 caagggaaga gacttcgcaa cagtcagaaa ggtcctgagc atgccgcagg tcaacatcgt 3360 caagaagaca gaagtccaga caggaggatt cagcaaggaa agcatcctgc cgaagagaaa 3420 cagcgacaag ctgatcgcaa gaaagaagga ctgggacccg aagaagtacg gaggattcga 3480 cagcccgaca gtcgcataca gcgtcctggt cgtcgcaaag gtcgaaaagg gaaagagcaa 3540 gaagctgaag agcgtcaagg aactgctggg aatcacaatc atggaaagaa gcagcttcga 3600 aaagaacccg atcgacttcc tggaagcaaa gggatacaag gaagtcaaga aggacctgat 3660 catcaagctg ccgaagtaca gcctgttcga actggaaaac ggaagaaaga gaatgctggc 3720 aagcgcagga gaactgcaga agggaaacga actggcactg ccgagcaagt acgtcaactt 3780 cctgtacctg gcaagccact acgaaaagct gaagggaagc ccggaagaca acgaacagaa 3840 gcagctgttc gtcgaacagc acaagcacta cctggacgaa atcatcgaac agatcagcga 3900 attcagcaag agagtcatcc tggcagacgc aaacctggac aaggtcctga gcgcatacaa 3960 caagcacaga gacaagccga tcagagaaca ggcagaaaac atcatccacc tgttcacact 4020 gacaaacctg ggagcaccgg cagcattcaa gtacttcgac acaacaatcg acagaaagag 4080 atacacaagc acaaaggaag tcctggacgc aacactgatc caccagagca tcacaggact 4140 gtacgaaaca agaatcgacc tgagccagct gggaggagac ggaggaggaa gcccgaagaa 4200 gaagagaaag gtctagctag ccatcacatt taaaagcatc tcagcctacc atgagaataa 4260 gagaaagaaa atgaagatca atagcttatt catctctttt tctttttcgt tggtgtaaag 4320 ccaacaccct gtctaaaaaa cataaatttc tttaatcatt ttgcctcttt tctctgtgct 4380 tcaattaata aaaaatggaa agaacctcga g 4411 <210> 44 <211> 4405 <212> ADN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 44 gggtcccgca gtcggcgtcc agcggctctg cttgttcgtg tgtgtgtcgt tgcaggcctt 60 attcggatcc atggacaaga agtacagcat cggactggac atcggaacaa acagcgtcgg 120 atgggcagtc atcacagacg aatacaaggt cccgagcaag aagttcaagg tcctgggaaa 180 cacagacaga cacagcatca agaagaacct gatcggagca ctgctgttcg acagcggaga 240 aacagcagaa gcaacaagac tgaagagaac agcaagaaga agatacacaa gaagaaagaa 300 cagaatctgc tacctgcagg aaatcttcag caacgaaatg gcaaaggtcg acgacagctt 360 cttccacaga ctggaagaaa gcttcctggt cgaagaagac aagaagcacg aaagacaccc 420 gatcttcgga aacatcgtcg acgaagtcgc ataccacgaa aagtacccga caatctacca 480 cctgagaaag aagctggtcg acagcacaga caaggcagac ctgagactga tctacctggc 540 actggcacac atgatcaagt tcagaggaca cttcctgatc gaaggagacc tgaacccgga 600 caacagcgac gtcgacaagc tgttcatcca gctggtccag acatacaacc agctgttcga 660 agaaaacccg atcaacgcaa gcggagtcga cgcaaaggca atcctgagcg caagactgag 720 caagagcaga agactggaaa acctgatcgc acagctgccg ggagaaaaga agaacggact 780 gttcggaaac ctgatcgcac tgagcctggg actgacaccg aacttcaaga gcaacttcga 840 cctggcagaa gacgcaaagc tgcagctgag caaggacaca tacgacgacg acctggacaa 900 cctgctggca cagatcggag accagtacgc agacctgttc ctggcagcaa agaacctgag 960 cgacgcaatc ctgctgagcg acatcctgag agtcaacaca gaaatcacaa aggcaccgct 1020 gagcgcaagc atgatcaaga gatacgacga acaccaccag gacctgacac tgctgaaggc 1080 actggtcaga cagcagctgc cggaaaagta caaggaaatc ttcttcgacc agagcaagaa 1140 cggatacgca ggatacatcg acggaggagc aagccaggaa gaattctaca agttcatcaa 1200 gccgatcctg gaaaagatgg acggaacaga agaactgctg gtcaagctga acagagaaga 1260 cctgctgaga aagcagagaa cattcgacaa cggaagcatc ccgcaccaga tccacctggg 1320 agaactgcac gcaatcctga gaagacagga agacttctac ccgttcctga aggacaacag 1380 agaaaagatc gaaaagatcc tgacattcag aatcccgtac tacgtcggac cgctggcaag 1440 aggaaacagc agattcgcat ggatgacaag aaagagcgaa gaaacaatca caccgtggaa 1500 cttcgaagaa gtcgtcgaca agggagcaag cgcacagagc ttcatcgaaa gaatgacaaa 1560 cttcgacaag aacctgccga acgaaaaggt cctgccgaag cacagcctgc tgtacgaata 1620 cttcacagtc tacaacgaac tgacaaaggt caagtacgtc acagaaggaa tgagaaagcc 1680 ggcattcctg agcggagaac agaagaaggc aatcgtcgac ctgctgttca agacaaacag 1740 aaaggtcaca gtcaagcagc tgaaggaaga ctacttcaag aagatcgaat gcttcgacag 1800 cgtcgaaatc agcggagtcg aagacagatt caacgcaagc ctgggaacat accacgacct 1860 gctgaagatc atcaaggaca aggacttcct ggacaacgaa gaaaacgaag acatcctgga 1920 agacatcgtc ctgacactga cactgttcga agacagagaa atgatcgaag aaagactgaa 1980 gacatacgca cacctgttcg acgacaaggt catgaagcag ctgaagagaa gaagatacac 2040 aggatgggga agactgagca gaaagctgat caacggaatc agagacaagc agagcggaaa 2100 gacaatcctg gacttcctga agagcgacgg attcgcaaac agaaacttca tgcagctgat 2160 ccacgacgac agcctgacat tcaaggaaga catccagaag gcacaggtca gcggacaggg 2220 agacagcctg cacgaacaca tcgcaaacct ggcaggaagc ccggcaatca agaagggaat 2280 cctgcagaca gtcaaggtcg tcgacgaact ggtcaaggtc atgggaagac acaagccgga 2340 aaacatcgtc atcgaaatgg caagagaaaa ccagacaaca cagaagggac agaagaacag 2400 cagagaaaga atgaagagaa tcgaagaagg aatcaaggaa ctgggaagcc agatcctgaa 2460 ggaacacccg gtcgaaaaca cacagctgca gaacgaaaag ctgtacctgt actacctgca 2520 gaacggaaga gacatgtacg tcgaccagga actggacatc aacagactga gcgactacga 2580 cgtcgaccac atcgtcccgc agagcttcct gaaggacgac agcatcgaca acaaggtcct 2640 gacaagaagc gacaagaaca gaggaaagag cgacaacgtc ccgagcgaag aagtcgtcaa 2700 gaagatgaag aactactgga gacagctgct gaacgcaaag ctgatcacac agagaaagtt 2760 cgacaacctg acaaaggcag agagaggagg actgagcgaa ctggacaagg caggattcat 2820 caagagacag ctggtcgaaa caagacagat cacaaagcac gtcgcacaga tcctggacag 2880 cagaatgaac acaaagtacg acgaaaacga caagctgatc agagaagtca aggtcatcac 2940 actgaagagc aagctggtca gcgacttcag aaaggacttc cagttctaca aggtcagaga 3000 aatcaacaac taccaccacg cacacgacgc atacctgaac gcagtcgtcg gaacagcact 3060 gatcaagaag tacccgaagc tggaaagcga attcgtctac ggagactaca aggtctacga 3120 cgtcagaaag atgatcgcaa agagcgaaca ggaaatcgga aaggcaacag caaagtactt 3180 cttctacagc aacatcatga acttcttcaa gacagaaatc acactggcaa acggagaaat 3240 cagaaagaga ccgctgatcg aaacaaacgg agaaacagga gaaatcgtct gggacaaggg 3300 aagagacttc gcaacagtca gaaaggtcct gagcatgccg caggtcaaca tcgtcaagaa 3360 gacagaagtc cagacaggag gattcagcaa ggaaagcatc ctgccgaaga gaaacagcga 3420 caagctgatc gcaagaaaga aggactggga cccgaagaag tacggaggat tcgacagccc 3480 gacagtcgca tacagcgtcc tggtcgtcgc aaaggtcgaa aagggaaaga gcaagaagct 3540 gaagagcgtc aaggaactgc tgggaatcac aatcatggaa agaagcagct tcgaaaagaa 3600 cccgatcgac ttcctggaag caaagggata caaggaagtc aagaaggacc tgatcatcaa 3660 gctgccgaag tacagcctgt tcgaactgga aaacggaaga aagagaatgc tggcaagcgc 3720 aggagaactg cagaagggaa acgaactggc actgccgagc aagtacgtca acttcctgta 3780 cctggcaagc cactacgaaa agctgaaggg aagcccggaa gacaacgaac agaagcagct 3840 gttcgtcgaa cagcacaagc actacctgga cgaaatcatc gaacagatca gcgaattcag 3900 caagagagtc atcctggcag acgcaaacct ggacaaggtc ctgagcgcat acaacaagca 3960 cagagacaag ccgatcagag aacaggcaga aaacatcatc cacctgttca cactgacaaa 4020 cctgggagca ccggcagcat tcaagtactt cgacacaaca atcgacagaa agagatacac 4080 aagcacaaag gaagtcctgg acgcaacact gatccaccag agcatcacag gactgtacga 4140 aacaagaatc gacctgagcc agctgggagg agacggagga ggaagcccga agaagaagag 4200 aaaggtctag ctagccatca catttaaaag catctcagcc taccatgaga ataagagaaa 4260 gaaaatgaag atcaatagct tattcatctc tttttctttt tcgttggtgt aaagccaaca 4320 ccctgtctaa aaaacataaa tttctttaat cattttgcct cttttctctg tgcttcaatt 4380 aataaaaaat ggaaagaacc tcgag 4405 <210> 45 <211> 4188 <212> ADN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 45 atggataaga agtactcgat cgggctggat atcggaacta attccgtggg ttgggcagtg 60 atcacggatg aatacaaagt gccgtccaag aagttcaagg tcctggggaa caccgataga 120 cacagcatca agaagaatct catcggagcc ctgctgtttg actccggcga aaccgcagaa 180 gcgacccggc tcaaacgtac cgcgaggcga cgctacaccc ggcggaagaa tcgcatctgc 240 tatctgcaag aaatcttttc gaacgaaatg gcaaaggtgg acgacagctt cttccaccgc 300 ctggaagaat ctttcctggt ggaggaggac aagaagcatg aacggcatcc tatctttgga 360 aacatcgtgg acgaagtggc gtaccacgaa aagtacccga ccatctacca tctgcggaag 420 aagttggttg actcaactga caaggccgac ctcagattga tctacttggc cctcgcccat 480 atgatcaaat tccgcggaca cttcctgatc gaaggcgatc tgaaccctga taactccgac 540 gtggataagc tgttcattca actggtgcag acctacaacc aactgttcga agaaaaccca 600 atcaatgcca gcggcgtcga tgccaaggcc atcctgtccg cccggctgtc gaagtcgcgg 660 cgcctcgaaa acctgatcgc acagctgccg ggagagaaga agaacggact tttcggcaac 720 ttgatcgctc tctcactggg actcactccc aatttcaagt ccaattttga cctggccgag 780 gacgcgaagc tgcaactctc aaaggacacc tacgacgacg acttggacaa tttgctggca 840 caaattggcg atcagtacgc ggatctgttc cttgccgcta agaacctttc ggacgcaatc 900 ttgctgtccg atatcctgcg cgtgaacacc gaaataacca aagcgccgct tagcgcctcg 960 atgattaagc ggtacgacga gcatcaccag gatctcacgc tgctcaaagc gctcgtgaga 1020 cagcaactgc ctgaaaagta caaggagatt ttcttcgacc agtccaagaa tgggtacgca 1080 gggtacatcg atggaggcgc cagccaggaa gagttctata agttcatcaa gccaatcctg 1140 gaaaagatgg acggaaccga agaactgctg gtcaagctga acagggagga tctgctccgc 1200 aaacagagaa cctttgacaa cggaagcatt ccacaccaga tccatctggg tgagctgcac 1260 gccatcttgc ggcgccagga ggacttttac ccattcctca aggacaaccg ggaaaagatc 1320 gagaaaattc tgacgttccg catcccgtat tacgtgggcc cactggcgcg cggcaattcg 1380 cgcttcgcgt ggatgactag aaaatcagag gaaaccatca ctccttggaa tttcgaggaa 1440 gttgtggata agggagcttc ggcacaatcc ttcatcgaac gaatgaccaa cttcgacaag 1500 aatctcccaa acgagaaggt gcttcctaag cacagcctcc tttacgaata cttcactgtc 1560 tacaacgaac tgactaaagt gaaatacgtt actgaaggaa tgaggaagcc ggcctttctg 1620 agcggagaac agaagaaagc gattgtcgat ctgctgttca agaccaaccg caaggtgacc 1680 gtcaagcagc ttaaagagga ctacttcaag aagatcgagt gtttcgactc agtggaaatc 1740 agcggagtgg aggacagatt caacgcttcg ctgggaacct atcatgatct cctgaagatc 1800 atcaaggaca aggacttcct tgacaacgag gagaacgagg acatcctgga agatatcgtc 1860 ctgaccttga cccttttcga ggatcgcgag atgatcgagg agaggcttaa gacctacgct 1920 catctcttcg acgataaggt catgaaacaa ctcaagcgcc gccggtacac tggttggggc 1980 cgcctctccc gcaagctgat caacggtatt cgcgataaac agagcggtaa aactatcctg 2040 gatttcctca aatcggatgg cttcgctaat cgtaacttca tgcagttgat ccacgacgac 2100 agcctgacct ttaaggagga catccagaaa gcacaagtga gcggacaggg agactcactc 2160 catgaacaca tcgcgaatct ggccggttcg ccggcgatta agaagggaat cctgcaaact 2220 gtgaaggtgg tggacgagct ggtgaaggtc atgggacggc acaaaccgga gaatatcgtg 2280 attgaaatgg cccgagaaaa ccagactacc cagaagggcc agaagaactc ccgcgaaagg 2340 atgaagcgga tcgaagaagg aatcaaggag ctgggcagcc agatcctgaa agagcacccg 2400 gtggaaaaca cgcagctgca gaacgagaag ctctacctgt actatttgca aaatggacgg 2460 gacatgtacg tggaccaaga gctggacatc aatcggttgt ctgattacga cgtggaccac 2520 atcgttccac agtcctttct gaaggatgac tccatcgata acaaggtgtt gactcgcagc 2580 gacaagaaca gagggaagtc agataatgtg ccatcggagg aggtcgtgaa gaagatgaag 2640 aattactggc ggcagctcct gaatgcgaag ctgattaccc agagaaagtt tgacaatctc 2700 actaaagccg agcgcggcgg actctcagag ctggataagg ctggattcat caaacggcag 2760 ctggtcgaga ctcggcagat taccaagcac gtggcgcaga tcctggactc ccgcatgaac 2820 actaaatacg acgagaacga taagctcatc cgggaagtga aggtgattac cctgaaaagc 2880 aaacttgtgt cggactttcg gaaggacttt cagttttaca aagtgagaga aatcaacaac 2940 taccatcacg cgcatgacgc atacctcaac gctgtggtcg gcaccgccct gatcaagaag 3000 taccctaaac ttgaatcgga gtttgtgtac ggagactaca aggtctacga cgtgaggaag 3060 atgatagcca agtccgaaca ggaaatcggg aaagcaactg cgaaatactt cttttactca 3120 aacatcatga acttcttcaa gactgaaatt acgctggcca atggagaaat caggaagagg 3180 ccactgatcg aaactaacgg agaaacgggc gaaatcgtgt gggacaaggg cagggacttc 3240 gcaactgttc gcaaagtgct ctctatgccg caagtcaata ttgtgaagaa aaccgaagtg 3300 caaaccggcg gattttcaaa ggaatcgatc ctcccaaaga gaaatagcga caagctcatt 3360 gcacgcaaga aagactggga cccgaagaag tacggaggat tcgattcgcc gactgtcgca 3420 tactccgtcc tcgtggtggc caaggtggag aagggaaaga gcaagaagct caaatccgtc 3480 aaagagctgc tggggattac catcatggaa cgatcctcgt tcgagaagaa cccgattgat 3540 ttcctggagg cgaagggtta caaggaggtg aagaaggatc tgatcatcaa actgcccaag 3600 tactcactgt tcgaactgga aaatggtcgg aagcgcatgc tggcttcggc cggagaactc 3660 cagaaaggaa atgagctggc cttgcctagc aagtacgtca acttcctcta tcttgcttcg 3720 cactacgaga aactcaaagg gtcaccggaa gataacgaac agaagcagct tttcgtggag 3780 cagcacaagc attatctgga tgaaatcatc gaacaaatct ccgagttttc aaagcgcgtg 3840 atcctcgccg acgccaacct cgacaaagtc ctgtcggcct acaataagca tagagataag 3900 ccgatcagag aacaggccga gaacattatc cacttgttca ccctgactaa cctgggagct 3960 ccagccgcct tcaagtactt cgatactact atcgaccgca aaagatacac gtccaccaag 4020 gaagttctgg acgcgaccct gatccaccaa agcatcactg gactctacga aactaggatc 4080 gatctgtcgc agctgggtgg cgatggtggc ggtggatcct acccatacga cgtgcctgac 4140 tacgcctccg gaggtggtgg ccccaagaag aaacggaagg tgtgatag 4188 <210> 46 <211> 4459 <212> ADN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 46 gggtcccgca gtcggcgtcc agcggctctg cttgttcgtg tgtgtgtcgt tgcaggcctt 60 attcggatct gccaccatgg ataagaagta ctcgatcggg ctggatatcg gaactaattc 120 cgtgggttgg gcagtgatca cggatgaata caaagtgccg tccaagaagt tcaaggtcct 180 ggggaacacc gatagacaca gcatcaagaa gaatctcatc ggagccctgc tgtttgactc 240 cggcgaaacc gcagaagcga cccggctcaa acgtaccgcg aggcgacgct acacccggcg 300 gaagaatcgc atctgctatc tgcaagaaat cttttcgaac gaaatggcaa aggtggacga 360 cagcttcttc caccgcctgg aagaatcttt cctggtggag gaggacaaga agcatgaacg 420 gcatcctatc tttggaaaca tcgtggacga agtggcgtac cacgaaaagt acccgaccat 480 ctaccatctg cggaagaagt tggttgactc aactgacaag gccgacctca gattgatcta 540 cttggccctc gcccatatga tcaaattccg cggacacttc ctgatcgaag gcgatctgaa 600 ccctgataac tccgacgtgg ataagctgtt cattcaactg gtgcagacct acaaccaact 660 gttcgaagaa aacccaatca atgccagcgg cgtcgatgcc aaggccatcc tgtccgcccg 720 gctgtcgaag tcgcggcgcc tcgaaaacct gatcgcacag ctgccgggag agaagaagaa 780 cggacttttc ggcaacttga tcgctctctc actgggactc actcccaatt tcaagtccaa 840 ttttgacctg gccgaggacg cgaagctgca actctcaaag gacacctacg acgacgactt 900 ggacaatttg ctggcacaaa ttggcgatca gtacgcggat ctgttccttg ccgctaagaa 960 cctttcggac gcaatcttgc tgtccgatat cctgcgcgtg aacaccgaaa taaccaaagc 1020 gccgcttagc gcctcgatga ttaagcggta cgacgagcat caccaggatc tcacgctgct 1080 caaagcgctc gtgagacagc aactgcctga aaagtacaag gagattttct tcgaccagtc 1140 caagaatggg tacgcagggt acatcgatgg aggcgccagc caggaagagt tctataagtt 1200 catcaagcca atcctggaaa agatggacgg aaccgaagaa ctgctggtca agctgaacag 1260 ggaggatctg ctccgcaaac agagaacctt tgacaacgga agcattccac accagatcca 1320 tctgggtgag ctgcacgcca tcttgcggcg ccaggaggac ttttacccat tcctcaagga 1380 caaccgggaa aagatcgaga aaattctgac gttccgcatc ccgtattacg tgggcccact 1440 ggcgcgcggc aattcgcgct tcgcgtggat gactagaaaa tcagaggaaa ccatcactcc 1500 ttggaatttc gaggaagttg tggataaggg agcttcggca caatccttca tcgaacgaat 1560 gaccaacttc gacaagaatc tcccaaacga gaaggtgctt cctaagcaca gcctccttta 1620 cgaatacttc actgtctaca acgaactgac taaagtgaaa tacgttactg aaggaatgag 1680 gaagccggcc tttctgagcg gagaacagaa gaaagcgatt gtcgatctgc tgttcaagac 1740 caaccgcaag gtgaccgtca agcagcttaa agaggactac ttcaagaaga tcgagtgttt 1800 cgactcagtg gaaatcagcg gagtggagga cagattcaac gcttcgctgg gaacctatca 1860 tgatctcctg aagatcatca aggacaagga cttccttgac aacgaggaga acgaggacat 1920 cctggaagat atcgtcctga ccttgaccct tttcgaggat cgcgagatga tcgaggagag 1980 gcttaagacc tacgctcatc tcttcgacga taaggtcatg aaacaactca agcgccgccg 2040 gtacactggt tggggccgcc tctcccgcaa gctgatcaac ggtattcgcg ataaacagag 2100 cggtaaaact atcctggatt tcctcaaatc ggatggcttc gctaatcgta acttcatgca 2160 gttgatccac gacgacagcc tgacctttaa ggaggacatc cagaaagcac aagtgagcgg 2220 acagggagac tcactccatg aacacatcgc gaatctggcc ggttcgccgg cgattaagaa 2280 gggaatcctg caaactgtga aggtggtgga cgagctggtg aaggtcatgg gacggcacaa 2340 accggagaat atcgtgattg aaatggcccg agaaaaccag actacccaga agggccagaa 2400 gaactcccgc gaaaggatga agcggatcga agaaggaatc aaggagctgg gcagccagat 2460 cctgaaagag cacccggtgg aaaacacgca gctgcagaac gagaagctct acctgtacta 2520 tttgcaaaat ggacgggaca tgtacgtgga ccaagagctg gacatcaatc ggttgtctga 2580 ttacgacgtg gaccacatcg ttccacagtc ctttctgaag gatgactcca tcgataacaa 2640 ggtgttgact cgcagcgaca agaacagagg gaagtcagat aatgtgccat cggaggaggt 2700 cgtgaagaag atgaagaatt actggcggca gctcctgaat gcgaagctga ttacccagag 2760 aaagtttgac aatctcacta aagccgagcg cggcggactc tcagagctgg ataaggctgg 2820 attcatcaaa cggcagctgg tcgagactcg gcagattacc aagcacgtgg cgcagatcct 2880 ggactcccgc atgaacacta aatacgacga gaacgataag ctcatccggg aagtgaaggt 2940 gattaccctg aaaagcaaac ttgtgtcgga ctttcggaag gactttcagt tttacaaagt 3000 gagagaaatc aacaactacc atcacgcgca tgacgcatac ctcaacgctg tggtcggcac 3060 cgccctgatc aagaagtacc ctaaacttga atcggagttt gtgtacggag actacaaggt 3120 ctacgacgtg aggaagatga tagccaagtc cgaacaggaa atcgggaaag caactgcgaa 3180 atacttcttt tactcaaaca tcatgaactt cttcaagact gaaattacgc tggccaatgg 3240 agaaatcagg aagaggccac tgatcgaaac taacggagaa acgggcgaaa tcgtgtggga 3300 caagggcagg gacttcgcaa ctgttcgcaa agtgctctct atgccgcaag tcaatattgt 3360 gaagaaaacc gaagtgcaaa ccggcggatt ttcaaaggaa tcgatcctcc caaagagaaa 3420 tagcgacaag ctcattgcac gcaagaaaga ctgggacccg aagaagtacg gaggattcga 3480 ttcgccgact gtcgcatact ccgtcctcgt ggtggccaag gtggagaagg gaaagagcaa 3540 gaagctcaaa tccgtcaaag agctgctggg gattaccatc atggaacgat cctcgttcga 3600 gaagaacccg attgatttcc tggaggcgaa gggttacaag gaggtgaaga aggatctgat 3660 catcaaactg cccaagtact cactgttcga actggaaaat ggtcggaagc gcatgctggc 3720 ttcggccgga gaactccaga aaggaaatga gctggccttg cctagcaagt acgtcaactt 3780 cctctatctt gcttcgcact acgagaaact caaagggtca ccggaagata acgaacagaa 3840 gcagcttttc gtggagcagc acaagcatta tctggatgaa atcatcgaac aaatctccga 3900 gttttcaaag cgcgtgatcc tcgccgacgc caacctcgac aaagtcctgt cggcctacaa 3960 taagcataga gataagccga tcagagaaca ggccgagaac attatccact tgttcaccct 4020 gactaacctg ggagctccag ccgccttcaa gtacttcgat actactatcg accgcaaaag 4080 atacacgtcc accaaggaag ttctggacgc gaccctgatc caccaaagca tcactggact 4140 ctacgaaact aggatcgatc tgtcgcagct gggtggcgat ggtggcggtg gatcctaccc 4200 atacgacgtg cctgactacg cctccggagg tggtggcccc aagaagaaac ggaaggtgtg 4260 atagctagcc atcacattta aaagcatctc agcctaccat gagaataaga gaaagaaaat 4320 gaagatcaat agcttattca tctctttttc tttttcgttg gtgtaaagcc aacaccctgt 4380 ctaaaaaaca taaatttctt taatcatttt gcctcttttc tctgtgcttc aattaataaa 4440 aaatggaaag aacctcgag 4459 <210> 47 <211> 4453 <212> ADN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 47 gggtcccgca gtcggcgtcc agcggctctg cttgttcgtg tgtgtgtcgt tgcaggcctt 60 attcggatct atggataaga agtactcgat cgggctggat atcggaacta attccgtggg 120 ttgggcagtg atcacggatg aatacaaagt gccgtccaag aagttcaagg tcctggggaa 180 caccgataga cacagcatca agaagaatct catcggagcc ctgctgtttg actccggcga 240 aaccgcagaa gcgacccggc tcaaacgtac cgcgaggcga cgctacaccc ggcggaagaa 300 tcgcatctgc tatctgcaag aaatcttttc gaacgaaatg gcaaaggtgg acgacagctt 360 cttccaccgc ctggaagaat ctttcctggt ggaggaggac aagaagcatg aacggcatcc 420 tatctttgga aacatcgtgg acgaagtggc gtaccacgaa aagtacccga ccatctacca 480 tctgcggaag aagttggttg actcaactga caaggccgac ctcagattga tctacttggc 540 cctcgcccat atgatcaaat tccgcggaca cttcctgatc gaaggcgatc tgaaccctga 600 taactccgac gtggataagc tgttcattca actggtgcag acctacaacc aactgttcga 660 agaaaaccca atcaatgcca gcggcgtcga tgccaaggcc atcctgtccg cccggctgtc 720 gaagtcgcgg cgcctcgaaa acctgatcgc acagctgccg ggagagaaga agaacggact 780 tttcggcaac ttgatcgctc tctcactggg actcactccc aatttcaagt ccaattttga 840 cctggccgag gacgcgaagc tgcaactctc aaaggacacc tacgacgacg acttggacaa 900 tttgctggca caaattggcg atcagtacgc ggatctgttc cttgccgcta agaacctttc 960 ggacgcaatc ttgctgtccg atatcctgcg cgtgaacacc gaaataacca aagcgccgct 1020 tagcgcctcg atgattaagc ggtacgacga gcatcaccag gatctcacgc tgctcaaagc 1080 gctcgtgaga cagcaactgc ctgaaaagta caaggagatt ttcttcgacc agtccaagaa 1140 tgggtacgca gggtacatcg atggaggcgc cagccaggaa gagttctata agttcatcaa 1200 gccaatcctg gaaaagatgg acggaaccga agaactgctg gtcaagctga acagggagga 1260 tctgctccgc aaacagagaa cctttgacaa cggaagcatt ccacaccaga tccatctggg 1320 tgagctgcac gccatcttgc ggcgccagga ggacttttac ccattcctca aggacaaccg 1380 ggaaaagatc gagaaaattc tgacgttccg catcccgtat tacgtgggcc cactggcgcg 1440 cggcaattcg cgcttcgcgt ggatgactag aaaatcagag gaaaccatca ctccttggaa 1500 tttcgaggaa gttgtggata agggagcttc ggcacaatcc ttcatcgaac gaatgaccaa 1560 cttcgacaag aatctcccaa acgagaaggt gcttcctaag cacagcctcc tttacgaata 1620 cttcactgtc tacaacgaac tgactaaagt gaaatacgtt actgaaggaa tgaggaagcc 1680 ggcctttctg agcggagaac agaagaaagc gattgtcgat ctgctgttca agaccaaccg 1740 caaggtgacc gtcaagcagc ttaaagagga ctacttcaag aagatcgagt gtttcgactc 1800 agtggaaatc agcggagtgg aggacagatt caacgcttcg ctgggaacct atcatgatct 1860 cctgaagatc atcaaggaca aggacttcct tgacaacgag gagaacgagg acatcctgga 1920 agatatcgtc ctgaccttga cccttttcga ggatcgcgag atgatcgagg agaggcttaa 1980 gacctacgct catctcttcg acgataaggt catgaaacaa ctcaagcgcc gccggtacac 2040 tggttggggc cgcctctccc gcaagctgat caacggtatt cgcgataaac agagcggtaa 2100 aactatcctg gatttcctca aatcggatgg cttcgctaat cgtaacttca tgcagttgat 2160 ccacgacgac agcctgacct ttaaggagga catccagaaa gcacaagtga gcggacaggg 2220 agactcactc catgaacaca tcgcgaatct ggccggttcg ccggcgatta agaagggaat 2280 cctgcaaact gtgaaggtgg tggacgagct ggtgaaggtc atgggacggc acaaaccgga 2340 gaatatcgtg attgaaatgg cccgagaaaa ccagactacc cagaagggcc agaagaactc 2400 ccgcgaaagg atgaagcgga tcgaagaagg aatcaaggag ctgggcagcc agatcctgaa 2460 agagcacccg gtggaaaaca cgcagctgca gaacgagaag ctctacctgt actatttgca 2520 aaatggacgg gacatgtacg tggaccaaga gctggacatc aatcggttgt ctgattacga 2580 cgtggaccac atcgttccac agtcctttct gaaggatgac tccatcgata acaaggtgtt 2640 gactcgcagc gacaagaaca gagggaagtc agataatgtg ccatcggagg aggtcgtgaa 2700 gaagatgaag aattactggc ggcagctcct gaatgcgaag ctgattaccc agagaaagtt 2760 tgacaatctc actaaagccg agcgcggcgg actctcagag ctggataagg ctggattcat 2820 caaacggcag ctggtcgaga ctcggcagat taccaagcac gtggcgcaga tcctggactc 2880 ccgcatgaac actaaatacg acgagaacga taagctcatc cgggaagtga aggtgattac 2940 cctgaaaagc aaacttgtgt cggactttcg gaaggacttt cagttttaca aagtgagaga 3000 aatcaacaac taccatcacg cgcatgacgc atacctcaac gctgtggtcg gcaccgccct 3060 gatcaagaag taccctaaac ttgaatcgga gtttgtgtac ggagactaca aggtctacga 3120 cgtgaggaag atgatagcca agtccgaaca ggaaatcggg aaagcaactg cgaaatactt 3180 cttttactca aacatcatga acttcttcaa gactgaaatt acgctggcca atggagaaat 3240 caggaagagg ccactgatcg aaactaacgg agaaacgggc gaaatcgtgt gggacaaggg 3300 cagggacttc gcaactgttc gcaaagtgct ctctatgccg caagtcaata ttgtgaagaa 3360 aaccgaagtg caaaccggcg gattttcaaa ggaatcgatc ctcccaaaga gaaatagcga 3420 caagctcatt gcacgcaaga aagactggga cccgaagaag tacggaggat tcgattcgcc 3480 gactgtcgca tactccgtcc tcgtggtggc caaggtggag aagggaaaga gcaagaagct 3540 caaatccgtc aaagagctgc tggggattac catcatggaa cgatcctcgt tcgagaagaa 3600 cccgattgat ttcctggagg cgaagggtta caaggaggtg aagaaggatc tgatcatcaa 3660 actgcccaag tactcactgt tcgaactgga aaatggtcgg aagcgcatgc tggcttcggc 3720 cggagaactc cagaaaggaa atgagctggc cttgcctagc aagtacgtca acttcctcta 3780 tcttgcttcg cactacgaga aactcaaagg gtcaccggaa gataacgaac agaagcagct 3840 tttcgtggag cagcacaagc attatctgga tgaaatcatc gaacaaatct ccgagttttc 3900 aaagcgcgtg atcctcgccg acgccaacct cgacaaagtc ctgtcggcct acaataagca 3960 tagagataag ccgatcagag aacaggccga gaacattatc cacttgttca ccctgactaa 4020 cctgggagct ccagccgcct tcaagtactt cgatactact atcgaccgca aaagatacac 4080 gtccaccaag gaagttctgg acgcgaccct gatccaccaa agcatcactg gactctacga 4140 aactaggatc gatctgtcgc agctgggtgg cgatggtggc ggtggatcct acccatacga 4200 cgtgcctgac tacgcctccg gaggtggtgg ccccaagaag aaacggaagg tgtgatagct 4260 agccatcaca tttaaaagca tctcagccta ccatgagaat aagagaaaga aaatgaagat 4320 caatagctta ttcatctctt tttctttttc gttggtgtaa agccaacacc ctgtctaaaa 4380 aacataaatt tctttaatca ttttgcctct tttctctgtg cttcaattaa taaaaaatgg 4440 aaagaacctc gag 4453 <210> 48 <211> 4403 <212> ADN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 48 gggtcccgca gtcggcgtcc agcggctctg cttgttcgtg tgtgtgtcgt tgcaggcctt 60 attcggatcc atgcctaaga aaaagcggaa ggtcgacggg gataagaagt actcaatcgg 120 gctggatatc ggaactaatt ccgtgggttg ggcagtgatc acggatgaat acaaagtgcc 180 gtccaagaag ttcaaggtcc tggggaacac cgatagacac agcatcaaga aaaatctcat 240 cggagccctg ctgtttgact ccggcgaaac cgcagaagcg acccggctca aacgtaccgc 300 gaggcgacgc tacacccggc ggaagaatcg catctgctat ctgcaagaga tcttttcgaa 360 cgaaatggca aaggtcgacg acagcttctt ccaccgcctg gaagaatctt tcctggtgga 420 ggaggacaag aagcatgaac ggcatcctat ctttggaaac atcgtcgacg aagtggcgta 480 ccacgaaaag tacccgacca tctaccatct gcggaagaag ttggttgact caactgacaa 540 ggccgacctc agattgatct acttggccct cgcccatatg atcaaattcc gcggacactt 600 cctgatcgaa ggcgatctga accctgataa ctccgacgtg gataagcttt tcattcaact 660 ggtgcagacc tacaaccaac tgttcgaaga aaacccaatc aatgctagcg gcgtcgatgc 720 caaggccatc ctgtccgccc ggctgtcgaa gtcgcggcgc ctcgaaaacc tgatcgcaca 780 gctgccggga gagaaaaaga acggactttt cggcaacttg atcgctctct cactgggact 840 cactcccaat ttcaagtcca attttgacct ggccgaggac gcgaagctgc aactctcaaa 900 ggacacctac gacgacgact tggacaattt gctggcacaa attggcgatc agtacgcgga 960 tctgttcctt gccgctaaga acctttcgga cgcaatcttg ctgtccgata tcctgcgcgt 1020 gaacaccgaa ataaccaaag cgccgcttag cgcctcgatg attaagcggt acgacgagca 1080 tcaccaggat ctcacgctgc tcaaagcgct cgtgagacag caactgcctg aaaagtacaa 1140 ggagatcttc ttcgaccagt ccaagaatgg gtacgcaggg tacatcgatg gaggcgctag 1200 ccaggaagag ttctataagt tcatcaagcc aatcctggaa aagatggacg gaaccgaaga 1260 actgctggtc aagctgaaca gggaggatct gctccggaaa cagagaacct ttgacaacgg 1320 atccattccc caccagatcc atctgggtga gctgcacgcc atcttgcggc gccaggagga 1380 cttttaccca ttcctcaagg acaaccggga aaagatcgag aaaattctga cgttccgcat 1440 cccgtattac gtgggcccac tggcgcgcgg caattcgcgc ttcgcgtgga tgactagaaa 1500 atcagaggaa accatcactc cttggaattt cgaggaagtt gtggataagg gagcttcggc 1560 acaaagcttc atcgaacgaa tgaccaactt cgacaagaat ctcccaaacg agaaggtgct 1620 tcctaagcac agcctccttt acgaatactt cactgtctac aacgaactga ctaaagtgaa 1680 atacgttact gaaggaatga ggaagccggc ctttctgtcc ggagaacaga agaaagcaat 1740 tgtcgatctg ctgttcaaga ccaaccgcaa ggtgaccgtc aagcagctta aagaggacta 1800 cttcaagaag atcgagtgtt tcgactcagt ggaaatcagc ggggtggagg acagattcaa 1860 cgcttcgctg ggaacctatc atgatctcct gaagatcatc aaggacaagg acttccttga 1920 caacgaggag aacgaggaca tcctggaaga tatcgtcctg accttgaccc ttttcgagga 1980 tcgcgagatg atcgaggaga ggcttaagac ctacgctcat ctcttcgacg ataaggtcat 2040 gaaacaactc aagcgccgcc ggtacactgg ttggggccgc ctctcccgca agctgatcaa 2100 cggtattcgc gataaacaga gcggtaaaac tatcctggat ttcctcaaat cggatggctt 2160 cgctaatcgt aacttcatgc aattgatcca cgacgacagc ctgaccttta aggaggacat 2220 ccaaaaagca caagtgtccg gacagggaga ctcactccat gaacacatcg cgaatctggc 2280 cggttcgccg gcgattaaga agggaattct gcaaactgtg aaggtggtcg acgagctggt 2340 gaaggtcatg ggacggcaca aaccggagaa tatcgtgatt gaaatggccc gagaaaacca 2400 gactacccag aagggccaga aaaactcccg cgaaaggatg aagcggatcg aagaaggaat 2460 caaggagctg ggcagccaga tcctgaaaga gcacccggtg gaaaacacgc agctgcagaa 2520 cgagaagctc tacctgtact atttgcaaaa tggacgggac atgtacgtgg accaagagct 2580 ggacatcaat cggttgtctg attacgacgt ggaccacatc gttccacagt cctttctgaa 2640 ggatgactcg atcgataaca aggtgttgac tcgcagcgac aagaacagag ggaagtcaga 2700 taatgtgcca tcggaggagg tcgtgaagaa gatgaagaat tactggcggc agctcctgaa 2760 tgcgaagctg attacccaga gaaagtttga caatctcact aaagccgagc gcggcggact 2820 ctcagagctg gataaggctg gattcatcaa acggcagctg gtcgagactc ggcagattac 2880 caagcacgtg gcgcagatct tggactcccg catgaacact aaatacgacg agaacgataa 2940 gctcatccgg gaagtgaagg tgattaccct gaaaagcaaa cttgtgtcgg actttcggaa 3000 ggactttcag ttttacaaag tgagagaaat caacaactac catcacgcgc atgacgcata 3060 cctcaacgct gtggtcggta ccgccctgat caaaaagtac cctaaacttg aatcggagtt 3120 tgtgtacgga gactacaagg tctacgacgt gaggaagatg atagccaagt ccgaacagga 3180 aatcgggaaa gcaactgcga aatacttctt ttactcaaac atcatgaact ttttcaagac 3240 tgaaattacg ctggccaatg gagaaatcag gaagaggcca ctgatcgaaa ctaacggaga 3300 aacgggcgaa atcgtgtggg acaagggcag ggacttcgca actgttcgca aagtgctctc 3360 tatgccgcaa gtcaatattg tgaagaaaac cgaagtgcaa accggcggat tttcaaagga 3420 atcgatcctc ccaaagagaa atagcgacaa gctcattgca cgcaagaaag actgggaccc 3480 gaagaagtac ggaggattcg attcgccgac tgtcgcatac tccgtcctcg tggtggccaa 3540 ggtggagaag ggaaagagca aaaagctcaa atccgtcaaa gagctgctgg ggattaccat 3600 catggaacga tcctcgttcg agaagaaccc gattgatttc ctcgaggcga agggttacaa 3660 ggaggtgaag aaggatctga tcatcaaact ccccaagtac tcactgttcg aactggaaaa 3720 tggtcggaag cgcatgctgg cttcggccgg agaactccaa aaaggaaatg agctggcctt 3780 gcctagcaag tacgtcaact tcctctatct tgcttcgcac tacgaaaaac tcaaagggtc 3840 accggaagat aacgaacaga agcagctttt cgtggagcag cacaagcatt atctggatga 3900 aatcatcgaa caaatctccg agttttcaaa gcgcgtgatc ctcgccgacg ccaacctcga 3960 caaagtcctg tcggcctaca ataagcatag agataagccg atcagagaac aggccgagaa 4020 cattatccac ttgttcaccc tgactaacct gggagcccca gccgccttca agtacttcga 4080 tactactatc gatcgcaaaa gatacacgtc caccaaggaa gttctggacg cgaccctgat 4140 ccaccaaagc atcactggac tctacgaaac taggatcgat ctgtcgcagc tgggtggcga 4200 ttgatagtct agccatcaca tttaaaagca tctcagccta ccatgagaat aagagaaaga 4260 aaatgaagat caatagctta ttcatctctt tttctttttc gttggtgtaa agccaacacc 4320 ctgtctaaaa aacataaatt tctttaatca ttttgcctct tttctctgtg cttcaattaa 4380 taaaaaatgg aaagaacctc gag 4403 <210> 49 <211> 4409 <212> ADN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 49 gggtcccgca gtcggcgtcc agcggctctg cttgttcgtg tgtgtgtcgt tgcaggcctt 60 attcggatcc gccaccatgc ctaagaaaaa gcggaaggtc gacggggata agaagtactc 120 aatcgggctg gatatcggaa ctaattccgt gggttgggca gtgatcacgg atgaatacaa 180 agtgccgtcc aagaagttca aggtcctggg gaacaccgat agacacagca tcaagaaaaa 240 tctcatcgga gccctgctgt ttgactccgg cgaaaccgca gaagcgaccc ggctcaaacg 300 taccgcgagg cgacgctaca cccggcggaa gaatcgcatc tgctatctgc aagagatctt 360 ttcgaacgaa atggcaaagg tcgacgacag cttcttccac cgcctggaag aatctttcct 420 ggtggaggag gacaagaagc atgaacggca tcctatcttt ggaaacatcg tcgacgaagt 480 ggcgtaccac gaaaagtacc cgaccatcta ccatctgcgg aagaagttgg ttgactcaac 540 tgacaaggcc gacctcagat tgatctactt ggccctcgcc catatgatca aattccgcgg 600 acacttcctg atcgaaggcg atctgaaccc tgataactcc gacgtggata agcttttcat 660 tcaactggtg cagacctaca accaactgtt cgaagaaaac ccaatcaatg ctagcggcgt 720 cgatgccaag gccatcctgt ccgcccggct gtcgaagtcg cggcgcctcg aaaacctgat 780 cgcacagctg ccgggagaga aaaagaacgg acttttcggc aacttgatcg ctctctcact 840 gggactcact cccaatttca agtccaattt tgacctggcc gaggacgcga agctgcaact 900 ctcaaaggac acctacgacg acgacttgga caatttgctg gcacaaattg gcgatcagta 960 cgcggatctg ttccttgccg ctaagaacct ttcggacgca atcttgctgt ccgatatcct 1020 gcgcgtgaac accgaaataa ccaaagcgcc gcttagcgcc tcgatgatta agcggtacga 1080 cgagcatcac caggatctca cgctgctcaa agcgctcgtg agacagcaac tgcctgaaaa 1140 gtacaaggag atcttcttcg accagtccaa gaatgggtac gcagggtaca tcgatggagg 1200 cgctagccag gaagagttct ataagttcat caagccaatc ctggaaaaga tggacggaac 1260 cgaagaactg ctggtcaagc tgaacaggga ggatctgctc cggaaacaga gaacctttga 1320 caacggatcc attccccacc agatccatct gggtgagctg cacgccatct tgcggcgcca 1380 ggaggacttt tacccattcc tcaaggacaa ccgggaaaag atcgagaaaa ttctgacgtt 1440 ccgcatcccg tattacgtgg gcccactggc gcgcggcaat tcgcgcttcg cgtggatgac 1500 tagaaaatca gaggaaacca tcactccttg gaatttcgag gaagttgtgg ataagggagc 1560 ttcggcacaa agcttcatcg aacgaatgac caacttcgac aagaatctcc caaacgagaa 1620 ggtgcttcct aagcacagcc tcctttacga atacttcact gtctacaacg aactgactaa 1680 agtgaaatac gttactgaag gaatgaggaa gccggccttt ctgtccggag aacagaagaa 1740 agcaattgtc gatctgctgt tcaagaccaa ccgcaaggtg accgtcaagc agcttaaaga 1800 ggactacttc aagaagatcg agtgtttcga ctcagtggaa atcagcgggg tggaggacag 1860 attcaacgct tcgctgggaa cctatcatga tctcctgaag atcatcaagg acaaggactt 1920 ccttgacaac gaggagaacg aggacatcct ggaagatatc gtcctgacct tgaccctttt 1980 cgaggatcgc gagatgatcg aggagaggct taagacctac gctcatctct tcgacgataa 2040 ggtcatgaaa caactcaagc gccgccggta cactggttgg ggccgcctct cccgcaagct 2100 gatcaacggt attcgcgata aacagagcgg taaaactatc ctggatttcc tcaaatcgga 2160 tggcttcgct aatcgtaact tcatgcaatt gatccacgac gacagcctga cctttaagga 2220 ggacatccaa aaagcacaag tgtccggaca gggagactca ctccatgaac acatcgcgaa 2280 tctggccggt tcgccggcga ttaagaaggg aattctgcaa actgtgaagg tggtcgacga 2340 gctggtgaag gtcatgggac ggcacaaacc ggagaatatc gtgattgaaa tggcccgaga 2400 aaaccagact acccagaagg gccagaaaaa ctcccgcgaa aggatgaagc ggatcgaaga 2460 aggaatcaag gagctgggca gccagatcct gaaagagcac ccggtggaaa acacgcagct 2520 gcagaacgag aagctctacc tgtactattt gcaaaatgga cgggacatgt acgtggacca 2580 agagctggac atcaatcggt tgtctgatta cgacgtggac cacatcgttc cacagtcctt 2640 tctgaaggat gactcgatcg ataacaaggt gttgactcgc agcgacaaga acagagggaa 2700 gtcagataat gtgccatcgg aggaggtcgt gaagaagatg aagaattact ggcggcagct 2760 cctgaatgcg aagctgatta cccagagaaa gtttgacaat ctcactaaag ccgagcgcgg 2820 cggactctca gagctggata aggctggatt catcaaacgg cagctggtcg agactcggca 2880 gattaccaag cacgtggcgc agatcttgga ctcccgcatg aacactaaat acgacgagaa 2940 cgataagctc atccgggaag tgaaggtgat taccctgaaa agcaaacttg tgtcggactt 3000 tcggaaggac tttcagtttt acaaagtgag agaaatcaac aactaccatc acgcgcatga 3060 cgcatacctc aacgctgtgg tcggtaccgc cctgatcaaa aagtacccta aacttgaatc 3120 ggagtttgtg tacggagact acaaggtcta cgacgtgagg aagatgatag ccaagtccga 3180 acaggaaatc gggaaagcaa ctgcgaaata cttcttttac tcaaacatca tgaacttttt 3240 caagactgaa attacgctgg ccaatggaga aatcaggaag aggccactga tcgaaactaa 3300 cggagaaacg ggcgaaatcg tgtgggacaa gggcagggac ttcgcaactg ttcgcaaagt 3360 gctctctatg ccgcaagtca atattgtgaa gaaaaccgaa gtgcaaaccg gcggattttc 3420 aaaggaatcg atcctcccaa agagaaatag cgacaagctc attgcacgca agaaagactg 3480 ggacccgaag aagtacggag gattcgattc gccgactgtc gcatactccg tcctcgtggt 3540 ggccaaggtg gagaagggaa agagcaaaaa gctcaaatcc gtcaaagagc tgctggggat 3600 taccatcatg gaacgatcct cgttcgagaa gaacccgatt gatttcctcg aggcgaaggg 3660 ttacaaggag gtgaagaagg atctgatcat caaactcccc aagtactcac tgttcgaact 3720 ggaaaatggt cggaagcgca tgctggcttc ggccggagaa ctccaaaaag gaaatgagct 3780 ggccttgcct agcaagtacg tcaacttcct ctatcttgct tcgcactacg aaaaactcaa 3840 agggtcaccg gaagataacg aacagaagca gcttttcgtg gagcagcaca agcattatct 3900 ggatgaaatc atcgaacaaa tctccgagtt ttcaaagcgc gtgatcctcg ccgacgccaa 3960 cctcgacaaa gtcctgtcgg cctacaataa gcatagagat aagccgatca gagaacaggc 4020 cgagaacatt atccacttgt tcaccctgac taacctggga gccccagccg ccttcaagta 4080 cttcgatact actatcgatc gcaaaagata cacgtccacc aaggaagttc tggacgcgac 4140 cctgatccac caaagcatca ctggactcta cgaaactagg atcgatctgt cgcagctggg 4200 tggcgattga tagtctagcc atcacattta aaagcatctc agcctaccat gagaataaga 4260 gaaagaaaat gaagatcaat agcttattca tctctttttc tttttcgttg gtgtaaagcc 4320 aacaccctgt ctaaaaaaca taaatttctt taatcatttt gcctcttttc tctgtgcttc 4380 aattaataaa aaatggaaag aacctcgag 4409 <210> 50 <211> 4140 <212> ADN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 50 atggacaaga agtacagcat cggactggac atcggaacaa acagcgtcgg atgggcagtc 60 atcacagacg aatacaaggt cccgagcaag aagttcaagg tcctgggaaa cacagacaga 120 cacagcatca agaagaacct gatcggagca ctgctgttcg acagcggaga aacagcagaa 180 gcaacaagac tgaagagaac agcaagaaga agatacacaa gaagaaagaa cagaatctgc 240 tacctgcagg aaatcttcag caacgaaatg gcaaaggtcg acgacagctt cttccaccgg 300 ctggaagaaa gcttcctggt cgaagaagac aagaagcacg aaagacaccc gatcttcgga 360 aacatcgtcg acgaagtcgc ataccacgaa aagtacccga caatctacca cctgagaaag 420 aagctggtcg acagcacaga caaggcagac ctgagactga tctacctggc actggcacac 480 atgatcaagt tcagaggaca cttcctgatc gaaggagacc tgaacccgga caacagcgac 540 gtcgacaagc tgttcatcca gctggtccag acatacaacc agctgttcga agaaaacccg 600 atcaacgcaa gcggagtcga cgcaaaggca atcctgagcg caagactgag caagagcaga 660 agactggaaa acctgatcgc acagctgccg ggagaaaaga agaacggact gttcggaaac 720 ctgatcgcac tgagcctggg actgacaccg aacttcaaga gcaacttcga cctggcagaa 780 gacgcaaagc tgcagctgag caaggacaca tacgacgacg acctggacaa cctgctggca 840 cagatcggag accagtacgc agacctgttc ctggcagcaa agaacctgag cgacgcaatc 900 ctgctgagcg acatcctgag agtcaacaca gaaatcacaa aggcaccgct gagcgcaagc 960 atgatcaaga gatacgacga acaccaccag gacctgacac tgctgaaggc actggtcaga 1020 cagcagctgc cggaaaagta caaggaaatc ttcttcgacc agagcaagaa cggatacgca 1080 ggatacatcg acggaggagc aagccaggaa gaattctaca agttcatcaa gccgatcctg 1140 gaaaagatgg acggaacaga agaactgctg gtcaagctga acagagaaga cctgctgaga 1200 aagcagagaa cattcgacaa cggaagcatc ccgcaccaga tccacctggg agaactgcac 1260 gcaatcctga gaagacagga agacttctac ccgttcctga aggacaacag agaaaagatc 1320 gaaaagatcc tgacattcag aatcccgtac tacgtcggac cgctggcaag aggaaacagc 1380 agattcgcat ggatgacaag aaagagcgaa gaaacaatca caccgtggaa cttcgaagaa 1440 gtcgtcgaca agggagcaag cgcacagagc ttcatcgaaa gaatgacaaa cttcgacaag 1500 aacctgccga acgaaaaggt cctgccgaag cacagcctgc tgtacgaata cttcacagtc 1560 tacaacgaac tgacaaaggt caagtacgtc acagaaggaa tgagaaagcc ggcattcctg 1620 agcggagaac agaagaaggc aatcgtcgac ctgctgttca agacaaacag aaaggtcaca 1680 gtcaagcagc tgaaggaaga ctacttcaag aagatcgaat gcttcgacag cgtcgaaatc 1740 agcggagtcg aagacagatt caacgcaagc ctgggaacat accacgacct gctgaagatc 1800 atcaaggaca aggacttcct ggacaacgaa gaaaacgaag acatcctgga agacatcgtc 1860 ctgacactga cactgttcga agacagagaa atgatcgaag aaagactgaa gacatacgca 1920 cacctgttcg acgacaaggt catgaagcag ctgaagagaa gaagatacac aggatgggga 1980 agactgagca gaaagctgat caacggaatc agagacaagc agagcggaaa gacaatcctg 2040 gacttcctga agagcgacgg attcgcaaac agaaacttca tgcagctgat ccacgacgac 2100 agcctgacat tcaaggaaga catccagaag gcacaggtca gcggacaggg agacagcctg 2160 cacgaacaca tcgcaaacct ggcaggaagc ccggcaatca agaagggaat cctgcagaca 2220 gtcaaggtcg tcgacgaact ggtcaaggtc atgggaagac acaagccgga aaacatcgtc 2280 atcgaaatgg caagagaaaa ccagacaaca cagaagggac agaagaacag cagagaaaga 2340 atgaagagaa tcgaagaagg aatcaaggaa ctgggaagcc agatcctgaa ggaacacccg 2400 gtcgaaaaca cacagctgca gaacgaaaag ctgtacctgt actacctgca aaacggaaga 2460 gacatgtacg tcgaccagga actggacatc aacagactga gcgactacga cgtcgaccac 2520 atcgtcccgc agagcttcct gaaggacgac agcatcgaca acaaggtcct gacaagaagc 2580 gacaagaaca gaggaaagag cgacaacgtc ccgagcgaag aagtcgtcaa gaagatgaag 2640 aactactgga gacagctgct gaacgcaaag ctgatcacac agagaaagtt cgacaacctg 2700 acaaaggcag agagaggagg actgagcgaa ctggacaagg caggattcat caagagacag 2760 ctggtcgaaa caagacagat cacaaagcac gtcgcacaga tcctggacag cagaatgaac 2820 acaaagtacg acgaaaacga caagctgatc agagaagtca aggtcatcac actgaagagc 2880 aagctggtca gcgacttcag aaaggacttc cagttctaca aggtcagaga aatcaacaac 2940 taccaccacg cacacgacgc atacctgaac gcagtcgtcg gaacagcact gatcaagaag 3000 tacccgaagc tggaaagcga attcgtctac ggagactaca aggtctacga cgtcagaaag 3060 atgatcgcaa agagcgaaca ggaaatcgga aaggcaacag caaagtactt cttctacagc 3120 aacatcatga acttcttcaa gacagaaatc acactggcaa acggagaaat cagaaagaga 3180 ccgctgatcg aaacaaacgg agaaacagga gaaatcgtct gggacaaggg aagagacttc 3240 gcaacagtca gaaaggtcct gagcatgccg caggtcaaca tcgtcaagaa gacagaagtc 3300 cagacaggag gattcagcaa ggaaagcatc ctgccgaaga gaaacagcga caagctgatc 3360 gcaagaaaga aggactggga cccgaagaag tacggaggat tcgacagccc gacagtcgca 3420 tacagcgtcc tggtcgtcgc aaaggtcgaa aagggaaaga gcaagaagct gaagagcgtc 3480 aaggaactgc tgggaatcac aatcatggaa agaagcagct tcgaaaagaa cccgatcgac 3540 ttcctggaag caaagggata caaggaagtc aagaaggacc tgatcatcaa gctgccgaag 3600 tacagcctgt tcgaactgga aaacggaaga aagagaatgc tggcaagcgc aggagaactg 3660 cagaagggaa acgaactggc actgccgagc aagtacgtca acttcctgta cctggcaagc 3720 cactacgaaa agctgaaggg aagcccggaa gacaacgaac agaagcagct gttcgtcgaa 3780 cagcacaagc actacctgga cgaaatcatc gaacagatca gcgaattcag caagagagtc 3840 atcctggcag acgcaaacct ggacaaggtc ctgagcgcat acaacaagca cagagacaag 3900 ccgatcagag aacaggcaga aaacatcatc cacctgttca cactgacaaa cctgggagca 3960 ccggcagcat tcaagtactt cgacacaaca atcgacagaa agagatacac aagcacaaag 4020 gaagtcctgg acgcaacact gatccaccag agcatcacag gactgtacga aacaagaatc 4080 gacctgagcc agctgggagg agacggagga ggaagcccga agaagaagag aaaggtctag 4140 <210> 51 <211> 4411 <212> ADN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 51 gggtcccgca gtcggcgtcc agcggctctg cttgttcgtg tgtgtgtcgt tgcaggcctt 60 attcggatcc gccaccatgg acaagaagta cagcatcgga ctggacatcg gaacaaacag 120 cgtcggatgg gcagtcatca cagacgaata caaggtcccg agcaagaagt tcaaggtcct 180 gggaaacaca gacagacaca gcatcaagaa gaacctgatc ggagcactgc tgttcgacag 240 cggagaaaca gcagaagcaa caagactgaa gagaacagca agaagaagat acacaagaag 300 aaagaacaga atctgctacc tgcaggaaat cttcagcaac gaaatggcaa aggtcgacga 360 cagcttcttc caccggctgg aagaaagctt cctggtcgaa gaagacaaga agcacgaaag 420 acacccgatc ttcggaaaca tcgtcgacga agtcgcatac cacgaaaagt acccgacaat 480 ctaccacctg agaaagaagc tggtcgacag cacagacaag gcagacctga gactgatcta 540 cctggcactg gcacacatga tcaagttcag aggacacttc ctgatcgaag gagacctgaa 600 cccggacaac agcgacgtcg acaagctgtt catccagctg gtccagacat acaaccagct 660 gttcgaagaa aacccgatca acgcaagcgg agtcgacgca aaggcaatcc tgagcgcaag 720 actgagcaag agcagaagac tggaaaacct gatcgcacag ctgccgggag aaaagaagaa 780 cggactgttc ggaaacctga tcgcactgag cctgggactg acaccgaact tcaagagcaa 840 cttcgacctg gcagaagacg caaagctgca gctgagcaag gacacatacg acgacgacct 900 ggacaacctg ctggcacaga tcggagacca gtacgcagac ctgttcctgg cagcaaagaa 960 cctgagcgac gcaatcctgc tgagcgacat cctgagagtc aacacagaaa tcacaaaggc 1020 accgctgagc gcaagcatga tcaagagata cgacgaacac caccaggacc tgacactgct 1080 gaaggcactg gtcagacagc agctgccgga aaagtacaag gaaatcttct tcgaccagag 1140 caagaacgga tacgcaggat acatcgacgg aggagcaagc caggaagaat tctacaagtt 1200 catcaagccg atcctggaaa agatggacgg aacagaagaa ctgctggtca agctgaacag 1260 agaagacctg ctgagaaagc agagaacatt cgacaacgga agcatcccgc accagatcca 1320 cctgggagaa ctgcacgcaa tcctgagaag acaggaagac ttctacccgt tcctgaagga 1380 caacagagaa aagatcgaaa agatcctgac attcagaatc ccgtactacg tcggaccgct 1440 ggcaagagga aacagcagat tcgcatggat gacaagaaag agcgaagaaa caatcacacc 1500 gtggaacttc gaagaagtcg tcgacaaggg agcaagcgca cagagcttca tcgaaagaat 1560 gacaaacttc gacaagaacc tgccgaacga aaaggtcctg ccgaagcaca gcctgctgta 1620 cgaatacttc acagtctaca acgaactgac aaaggtcaag tacgtcacag aaggaatgag 1680 aaagccggca ttcctgagcg gagaacagaa gaaggcaatc gtcgacctgc tgttcaagac 1740 aaacagaaag gtcacagtca agcagctgaa ggaagactac ttcaagaaga tcgaatgctt 1800 cgacagcgtc gaaatcagcg gagtcgaaga cagattcaac gcaagcctgg gaacatacca 1860 cgacctgctg aagatcatca aggacaagga cttcctggac aacgaagaaa acgaagacat 1920 cctggaagac atcgtcctga cactgacact gttcgaagac agagaaatga tcgaagaaag 1980 actgaagaca tacgcacacc tgttcgacga caaggtcatg aagcagctga agagaagaag 2040 atacacagga tggggaagac tgagcagaaa gctgatcaac ggaatcagag acaagcagag 2100 cggaaagaca atcctggact tcctgaagag cgacggattc gcaaacagaa acttcatgca 2160 gctgatccac gacgacagcc tgacattcaa ggaagacatc cagaaggcac aggtcagcgg 2220 acagggagac agcctgcacg aacacatcgc aaacctggca ggaagcccgg caatcaagaa 2280 gggaatcctg cagacagtca aggtcgtcga cgaactggtc aaggtcatgg gaagacacaa 2340 gccggaaaac atcgtcatcg aaatggcaag agaaaaccag acaacacaga agggacagaa 2400 gaacagcaga gaaagaatga agagaatcga agaaggaatc aaggaactgg gaagccagat 2460 cctgaaggaa cacccggtcg aaaacacaca gctgcagaac gaaaagctgt acctgtacta 2520 cctgcaaaac ggaagagaca tgtacgtcga ccaggaactg gacatcaaca gactgagcga 2580 ctacgacgtc gaccacatcg tcccgcagag cttcctgaag gacgacagca tcgacaacaa 2640 ggtcctgaca agaagcgaca agaacagagg aaagagcgac aacgtcccga gcgaagaagt 2700 cgtcaagaag atgaagaact actggagaca gctgctgaac gcaaagctga tcacacagag 2760 aaagttcgac aacctgacaa aggcagagag aggaggactg agcgaactgg acaaggcagg 2820 attcatcaag agacagctgg tcgaaacaag acagatcaca aagcacgtcg cacagatcct 2880 ggacagcaga atgaacacaa agtacgacga aaacgacaag ctgatcagag aagtcaaggt 2940 catcacactg aagagcaagc tggtcagcga cttcagaaag gacttccagt tctacaaggt 3000 cagagaaatc aacaactacc accacgcaca cgacgcatac ctgaacgcag tcgtcggaac 3060 agcactgatc aagaagtacc cgaagctgga aagcgaattc gtctacggag actacaaggt 3120 ctacgacgtc agaaagatga tcgcaaagag cgaacaggaa atcggaaagg caacagcaaa 3180 gtacttcttc tacagcaaca tcatgaactt cttcaagaca gaaatcacac tggcaaacgg 3240 agaaatcaga aagagaccgc tgatcgaaac aaacggagaa acaggagaaa tcgtctggga 3300 caagggaaga gacttcgcaa cagtcagaaa ggtcctgagc atgccgcagg tcaacatcgt 3360 caagaagaca gaagtccaga caggaggatt cagcaaggaa agcatcctgc cgaagagaaa 3420 cagcgacaag ctgatcgcaa gaaagaagga ctgggacccg aagaagtacg gaggattcga 3480 cagcccgaca gtcgcataca gcgtcctggt cgtcgcaaag gtcgaaaagg gaaagagcaa 3540 gaagctgaag agcgtcaagg aactgctggg aatcacaatc atggaaagaa gcagcttcga 3600 aaagaacccg atcgacttcc tggaagcaaa gggatacaag gaagtcaaga aggacctgat 3660 catcaagctg ccgaagtaca gcctgttcga actggaaaac ggaagaaaga gaatgctggc 3720 aagcgcagga gaactgcaga agggaaacga actggcactg ccgagcaagt acgtcaactt 3780 cctgtacctg gcaagccact acgaaaagct gaagggaagc ccggaagaca acgaacagaa 3840 gcagctgttc gtcgaacagc acaagcacta cctggacgaa atcatcgaac agatcagcga 3900 attcagcaag agagtcatcc tggcagacgc aaacctggac aaggtcctga gcgcatacaa 3960 caagcacaga gacaagccga tcagagaaca ggcagaaaac atcatccacc tgttcacact 4020 gacaaacctg ggagcaccgg cagcattcaa gtacttcgac acaacaatcg acagaaagag 4080 atacacaagc acaaaggaag tcctggacgc aacactgatc caccagagca tcacaggact 4140 gtacgaaaca agaatcgacc tgagccagct gggaggagac ggaggaggaa gcccgaagaa 4200 gaagagaaag gtctagctag ccatcacatt taaaagcatc tcagcctacc atgagaataa 4260 gagaaagaaa atgaagatca atagcttatt catctctttt tctttttcgt tggtgtaaag 4320 ccaacaccct gtctaaaaaa cataaatttc tttaatcatt ttgcctcttt tctctgtgct 4380 tcaattaata aaaaatggaa agaacctcga g 4411 <210> 52 <211> 4140 <212> ADN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 52 atggacaaga agtacagcat cggcctggac atcggcacca acagcgtggg ctgggccgtg 60 atcaccgacg agtacaaggt gcccagcaag aagttcaagg tgctgggcaa caccgacaga 120 cacagcatca agaagaacct gatcggcgcc ctgctgttcg acagcggcga gaccgccgag 180 gccaccagac tgaagagaac cgccagaaga agatacacca gaagaaagaa cagaatctgc 240 tacctgcagg agatcttcag caacgagatg gccaaggtgg acgacagctt cttccacaga 300 ctggaggaga gcttcctggt ggaggaggac aagaagcacg agagacaccc catcttcggc 360 aacatcgtgg acgaggtggc ctaccacgag aagtacccca ccatctacca cctgagaaag 420 aagctggtgg acagcaccga caaggccgac ctgagactga tctacctggc cctggcccac 480 atgatcaagt tcagaggcca cttcctgatc gagggcgacc tgaaccccga caacagcgac 540 gtggacaagc tgttcatcca gctggtgcag acctacaacc agctgttcga ggagaacccc 600 atcaacgcca gcggcgtgga cgccaaggcc atcctgagcg ccagactgag caagagcaga 660 agactggaga acctgatcgc ccagctgccc ggcgagaaga agaacggcct gttcggcaac 720 ctgatcgccc tgagcctggg cctgaccccc aacttcaaga gcaacttcga cctggccgag 780 gacgccaagc tgcagctgag caaggacacc tacgacgacg acctggacaa cctgctggcc 840 cagatcggcg accagtacgc cgacctgttc ctggccgcca agaacctgag cgacgccatc 900 ctgctgagcg acatcctgag agtgaacacc gagatcacca aggcccccct gagcgccagc 960 atgatcaaga gatacgacga gcaccaccag gacctgaccc tgctgaaggc cctggtgaga 1020 cagcagctgc ccgagaagta caaggagatc ttcttcgacc agagcaagaa cggctacgcc 1080 ggctacatcg acggcggcgc cagccaggag gagttctaca agttcatcaa gcccatcctg 1140 gagaagatgg acggcaccga ggagctgctg gtgaagctga acagagagga cctgctgaga 1200 aagcagagaa ccttcgacaa cggcagcatc ccccaccaga tccacctggg cgagctgcac 1260 gccatcctga gaagacagga ggacttctac cccttcctga aggacaacag agagaagatc 1320 gagaagatcc tgaccttcag aatcccctac tacgtgggcc ccctggccag aggcaacagc 1380 agattcgcct ggatgaccag aaagagcgag gagaccatca ccccctggaa cttcgaggag 1440 gtggtggaca agggcgccag cgcccagagc ttcatcgaga gaatgaccaa cttcgacaag 1500 aacctgccca acgagaaggt gctgcccaag cacagcctgc tgtacgagta cttcaccgtg 1560 tacaacgagc tgaccaaggt gaagtacgtg accgagggca tgagaaagcc cgccttcctg 1620 agcggcgagc agaagaaggc catcgtggac ctgctgttca agaccaacag aaaggtgacc 1680 gtgaagcagc tgaaggagga ctacttcaag aagatcgagt gcttcgacag cgtggagatc 1740 agcggcgtgg aggacagatt caacgccagc ctgggcacct accacgacct gctgaagatc 1800 atcaaggaca aggacttcct ggacaacgag gagaacgagg acatcctgga ggacatcgtg 1860 ctgaccctga ccctgttcga ggacagagag atgatcgagg agagactgaa gacctacgcc 1920 cacctgttcg acgacaaggt gatgaagcag ctgaagagaa gaagatacac cggctggggc 1980 agactgagca gaaagctgat caacggcatc agagacaagc agagcggcaa gaccatcctg 2040 gacttcctga agagcgacgg cttcgccaac agaaacttca tgcagctgat ccacgacgac 2100 agcctgacct tcaaggagga catccagaag gcccaggtga gcggccaggg cgacagcctg 2160 cacgagcaca tcgccaacct ggccggcagc cccgccatca agaagggcat cctgcagacc 2220 gtgaaggtgg tggacgagct ggtgaaggtg atgggcagac acaagcccga gaacatcgtg 2280 atcgagatgg ccagagagaa ccagaccacc cagaagggcc agaagaacag cagagagaga 2340 atgaagagaa tcgaggaggg catcaaggag ctgggcagcc agatcctgaa ggagcacccc 2400 gtggagaaca cccagctgca gaacgagaag ctgtacctgt actacctgca gaacggcaga 2460 gacatgtacg tggaccagga gctggacatc aacagactga gcgactacga cgtggaccac 2520 atcgtgcccc agagcttcct gaaggacgac agcatcgaca acaaggtgct gaccagaagc 2580 gacaagaaca gaggcaagag cgacaacgtg cccagcgagg aggtggtgaa gaagatgaag 2640 aactactgga gacagctgct gaacgccaag ctgatcaccc agagaaagtt cgacaacctg 2700 accaaggccg agagaggcgg cctgagcgag ctggacaagg ccggcttcat caagagacag 2760 ctggtggaga ccagacagat caccaagcac gtggcccaga tcctggacag cagaatgaac 2820 accaagtacg acgagaacga caagctgatc agagaggtga aggtgatcac cctgaagagc 2880 aagctggtga gcgacttcag aaaggacttc cagttctaca aggtgagaga gatcaacaac 2940 taccaccacg cccacgacgc ctacctgaac gccgtggtgg gcaccgccct gatcaagaag 3000 taccccaagc tggagagcga gttcgtgtac ggcgactaca aggtgtacga cgtgagaaag 3060 atgatcgcca agagcgagca ggagatcggc aaggccaccg ccaagtactt cttctacagc 3120 aacatcatga acttcttcaa gaccgagatc accctggcca acggcgagat cagaaagaga 3180 cccctgatcg agaccaacgg cgagaccggc gagatcgtgt gggacaaggg cagagacttc 3240 gccaccgtga gaaaggtgct gagcatgccc caggtgaaca tcgtgaagaa gaccgaggtg 3300 cagaccggcg gcttcagcaa ggagagcatc ctgcccaaga gaaacagcga caagctgatc 3360 gccagaaaga aggactggga ccccaagaag tacggcggct tcgacagccc caccgtggcc 3420 tacagcgtgc tggtggtggc caaggtggag aagggcaaga gcaagaagct gaagagcgtg 3480 aaggagctgc tgggcatcac catcatggag agaagcagct tcgagaagaa ccccatcgac 3540 ttcctggagg ccaagggcta caaggaggtg aagaaggacc tgatcatcaa gctgcccaag 3600 tacagcctgt tcgagctgga gaacggcaga aagagaatgc tggccagcgc cggcgagctg 3660 cagaagggca acgagctggc cctgcccagc aagtacgtga acttcctgta cctggccagc 3720 cactacgaga agctgaaggg cagccccgag gacaacgagc agaagcagct gttcgtggag 3780 cagcacaagc actacctgga cgagatcatc gagcagatca gcgagttcag caagagagtg 3840 atcctggccg acgccaacct ggacaaggtg ctgagcgcct acaacaagca cagagacaag 3900 cccatcagag agcaggccga gaacatcatc cacctgttca ccctgaccaa cctgggcgcc 3960 cccgccgcct tcaagtactt cgacaccacc atcgacagaa agagatacac cagcaccaag 4020 gaggtgctgg acgccaccct gatccaccag agcatcaccg gcctgtacga gaccagaatc 4080 gacctgagcc agctgggcgg cgacggcggc ggcagcccca agaagaagag aaaggtgtga 4140 <210> 53 <211> 4411 <212> ADN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 53 gggtcccgca gtcggcgtcc agcggctctg cttgttcgtg tgtgtgtcgt tgcaggcctt 60 attcggatcc gccaccatgg acaagaagta cagcatcggc ctggacatcg gcaccaacag 120 cgtgggctgg gccgtgatca ccgacgagta caaggtgccc agcaagaagt tcaaggtgct 180 gggcaacacc gacagacaca gcatcaagaa gaacctgatc ggcgccctgc tgttcgacag 240 cggcgagacc gccgaggcca ccagactgaa gagaaccgcc agaagaagat acaccagaag 300 aaagaacaga atctgctacc tgcaggagat cttcagcaac gagatggcca aggtggacga 360 cagcttcttc cacagactgg aggagagctt cctggtggag gaggacaaga agcacgagag 420 acaccccatc ttcggcaaca tcgtggacga ggtggcctac cacgagaagt accccaccat 480 ctaccacctg agaaagaagc tggtggacag caccgacaag gccgacctga gactgatcta 540 cctggccctg gcccacatga tcaagttcag aggccacttc ctgatcgagg gcgacctgaa 600 ccccgacaac agcgacgtgg acaagctgtt catccagctg gtgcagacct acaaccagct 660 gttcgaggag aaccccatca acgccagcgg cgtggacgcc aaggccatcc tgagcgccag 720 actgagcaag agcagaagac tggagaacct gatcgcccag ctgcccggcg agaagaagaa 780 cggcctgttc ggcaacctga tcgccctgag cctgggcctg acccccaact tcaagagcaa 840 cttcgacctg gccgaggacg ccaagctgca gctgagcaag gacacctacg acgacgacct 900 ggacaacctg ctggcccaga tcggcgacca gtacgccgac ctgttcctgg ccgccaagaa 960 cctgagcgac gccatcctgc tgagcgacat cctgagagtg aacaccgaga tcaccaaggc 1020 ccccctgagc gccagcatga tcaagagata cgacgagcac caccaggacc tgaccctgct 1080 gaaggccctg gtgagacagc agctgcccga gaagtacaag gagatcttct tcgaccagag 1140 caagaacggc tacgccggct acatcgacgg cggcgccagc caggaggagt tctacaagtt 1200 catcaagccc atcctggaga agatggacgg caccgaggag ctgctggtga agctgaacag 1260 agaggacctg ctgagaaagc agagaacctt cgacaacggc agcatccccc accagatcca 1320 cctgggcgag ctgcacgcca tcctgagaag acaggaggac ttctacccct tcctgaagga 1380 caacagagag aagatcgaga agatcctgac cttcagaatc ccctactacg tgggccccct 1440 ggccagaggc aacagcagat tcgcctggat gaccagaaag agcgaggaga ccatcacccc 1500 ctggaacttc gaggaggtgg tggacaaggg cgccagcgcc cagagcttca tcgagagaat 1560 gaccaacttc gacaagaacc tgcccaacga gaaggtgctg cccaagcaca gcctgctgta 1620 cgagtacttc accgtgtaca acgagctgac caaggtgaag tacgtgaccg agggcatgag 1680 aaagcccgcc ttcctgagcg gcgagcagaa gaaggccatc gtggacctgc tgttcaagac 1740 caacagaaag gtgaccgtga agcagctgaa ggaggactac ttcaagaaga tcgagtgctt 1800 cgacagcgtg gagatcagcg gcgtggagga cagattcaac gccagcctgg gcacctacca 1860 cgacctgctg aagatcatca aggacaagga cttcctggac aacgaggaga acgaggacat 1920 cctggaggac atcgtgctga ccctgaccct gttcgaggac agagagatga tcgaggagag 1980 actgaagacc tacgcccacc tgttcgacga caaggtgatg aagcagctga agagaagaag 2040 atacaccggc tggggcagac tgagcagaaa gctgatcaac ggcatcagag acaagcagag 2100 cggcaagacc atcctggact tcctgaagag cgacggcttc gccaacagaa acttcatgca 2160 gctgatccac gacgacagcc tgaccttcaa ggaggacatc cagaaggccc aggtgagcgg 2220 ccagggcgac agcctgcacg agcacatcgc caacctggcc ggcagccccg ccatcaagaa 2280 gggcatcctg cagaccgtga aggtggtgga cgagctggtg aaggtgatgg gcagacacaa 2340 gcccgagaac atcgtgatcg agatggccag agagaaccag accacccaga agggccagaa 2400 gaacagcaga gagagaatga agagaatcga ggagggcatc aaggagctgg gcagccagat 2460 cctgaaggag caccccgtgg agaacaccca gctgcagaac gagaagctgt acctgtacta 2520 cctgcagaac ggcagagaca tgtacgtgga ccaggagctg gacatcaaca gactgagcga 2580 ctacgacgtg gaccacatcg tgccccagag cttcctgaag gacgacagca tcgacaacaa 2640 ggtgctgacc agaagcgaca agaacagagg caagagcgac aacgtgccca gcgaggaggt 2700 ggtgaagaag atgaagaact actggagaca gctgctgaac gccaagctga tcacccagag 2760 aaagttcgac aacctgacca aggccgagag aggcggcctg agcgagctgg acaaggccgg 2820 cttcatcaag agacagctgg tggagaccag acagatcacc aagcacgtgg cccagatcct 2880 ggacagcaga atgaacacca agtacgacga gaacgacaag ctgatcagag aggtgaaggt 2940 gatcaccctg aagagcaagc tggtgagcga cttcagaaag gacttccagt tctacaaggt 3000 gagagagatc aacaactacc accacgccca cgacgcctac ctgaacgccg tggtgggcac 3060 cgccctgatc aagaagtacc ccaagctgga gagcgagttc gtgtacggcg actacaaggt 3120 gtacgacgtg agaaagatga tcgccaagag cgagcaggag atcggcaagg ccaccgccaa 3180 gtacttcttc tacagcaaca tcatgaactt cttcaagacc gagatcaccc tggccaacgg 3240 cgagatcaga aagagacccc tgatcgagac caacggcgag accggcgaga tcgtgtggga 3300 caagggcaga gacttcgcca ccgtgagaaa ggtgctgagc atgccccagg tgaacatcgt 3360 gaagaagacc gaggtgcaga ccggcggctt cagcaaggag agcatcctgc ccaagagaaa 3420 cagcgacaag ctgatcgcca gaaagaagga ctgggacccc aagaagtacg gcggcttcga 3480 cagccccacc gtggcctaca gcgtgctggt ggtggccaag gtggagaagg gcaagagcaa 3540 gaagctgaag agcgtgaagg agctgctggg catcaccatc atggagagaa gcagcttcga 3600 gaagaacccc atcgacttcc tggaggccaa gggctacaag gaggtgaaga aggacctgat 3660 catcaagctg cccaagtaca gcctgttcga gctggagaac ggcagaaaga gaatgctggc 3720 cagcgccggc gagctgcaga agggcaacga gctggccctg cccagcaagt acgtgaactt 3780 cctgtacctg gccagccact acgagaagct gaagggcagc cccgaggaca acgagcagaa 3840 gcagctgttc gtggagcagc acaagcacta cctggacgag atcatcgagc agatcagcga 3900 gttcagcaag agagtgatcc tggccgacgc caacctggac aaggtgctga gcgcctacaa 3960 caagcacaga gacaagccca tcagagagca ggccgagaac atcatccacc tgttcaccct 4020 gaccaacctg ggcgcccccg ccgccttcaa gtacttcgac accaccatcg acagaaagag 4080 atacaccagc accaaggagg tgctggacgc caccctgatc caccagagca tcaccggcct 4140 gtacgagacc agaatcgacc tgagccagct gggcggcgac ggcggcggca gccccaagaa 4200 gaagagaaag gtgtgactag ccatcacatt taaaagcatc tcagcctacc atgagaataa 4260 gagaaagaaa atgaagatca atagcttatt catctctttt tctttttcgt tggtgtaaag 4320 ccaacaccct gtctaaaaaa cataaatttc tttaatcatt ttgcctcttt tctctgtgct 4380 tcaattaata aaaaatggaa agaacctcga g 4411 <210> 54 <211> 4140 <212> ADN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 54 atggacaaaa aatacagcat agggctagac atagggacga acagcgtagg gtgggcggta 60 ataacggacg aatacaaagt accgagcaaa aaattcaaag tactagggaa cacggaccga 120 cacagcataa aaaaaaacct aataggggcg ctactattcg acagcgggga aacggcggaa 180 gcgacgcgac taaaacgaac ggcgcgacga cgatacacgc gacgaaaaaa ccgaatatgc 240 tacctacaag aaatattcag caacgaaatg gcgaaagtag acgacagctt cttccaccga 300 ctagaagaaa gcttcctagt agaagaagac aaaaaacacg aacgacaccc gatattcggg 360 aacatagtag acgaagtagc gtaccacgaa aaatacccga cgatatacca cctacgaaaa 420 aaactagtag acagcacgga caaagcggac ctacgactaa tatacctagc gctagcgcac 480 atgataaaat tccgagggca cttcctaata gaaggggacc taaacccgga caacagcgac 540 gtagacaaac tattcataca actagtacaa acgtacaacc aactattcga agaaaacccg 600 ataaacgcga gcggggtaga cgcgaaagcg atactaagcg cgcgactaag caaaagccga 660 cgactagaaa acctaatagc gcaactaccg ggggaaaaaa aaaacgggct attcgggaac 720 ctaatagcgc taagcctagg gctaacgccg aacttcaaaa gcaacttcga cctagcggaa 780 gacgcgaaac tacaactaag caaagacacg tacgacgacg acctagacaa cctactagcg 840 caaatagggg accaatacgc ggacctattc ctagcggcga aaaacctaag cgacgcgata 900 ctactaagcg acatactacg agtaaacacg gaaataacga aagcgccgct aagcgcgagc 960 atgataaaac gatacgacga acaccaccaa gacctaacgc tactaaaagc gctagtacga 1020 caacaactac cggaaaaata caaagaaata ttcttcgacc aaagcaaaaa cgggtacgcg 1080 gggtacatag acgggggggc gagccaagaa gaattctaca aattcataaa accgatacta 1140 gaaaaaatgg acgggacgga agaactacta gtaaaactaa accgagaaga cctactacga 1200 aaacaacgaa cgttcgacaa cgggagcata ccgcaccaaa tacacctagg ggaactacac 1260 gcgatactac gacgacaaga agacttctac ccgttcctaa aagacaaccg agaaaaaata 1320 gaaaaaatac taacgttccg aataccgtac tacgtagggc cgctagcgcg agggaacagc 1380 cgattcgcgt ggatgacgcg aaaaagcgaa gaaacgataa cgccgtggaa cttcgaagaa 1440 gtagtagaca aaggggcgag cgcgcaaagc ttcatagaac gaatgacgaa cttcgacaaa 1500 aacctaccga acgaaaaagt actaccgaaa cacagcctac tatacgaata cttcacggta 1560 tacaacgaac taacgaaagt aaaatacgta acggaaggga tgcgaaaacc ggcgttccta 1620 agcggggaac aaaaaaaagc gatagtagac ctactattca aaacgaaccg aaaagtaacg 1680 gtaaaacaac taaaagaaga ctacttcaaa aaaatagaat gcttcgacag cgtagaaata 1740 agcggggtag aagaccgatt caacgcgagc ctagggacgt accacgacct actaaaaata 1800 ataaaagaca aagacttcct agacaacgaa gaaaacgaag acatactaga agacatagta 1860 ctaacgctaa cgctattcga agaccgagaa atgatagaag aacgactaaa aacgtacgcg 1920 cacctattcg acgacaaagt aatgaaacaa ctaaaacgac gacgatacac ggggtggggg 1980 cgactaagcc gaaaactaat aaacgggata cgagacaaac aaagcgggaa aacgatacta 2040 gacttcctaa aaagcgacgg gttcgcgaac cgaaacttca tgcaactaat acacgacgac 2100 agcctaacgt tcaaagaaga catacaaaaa gcgcaagtaa gcgggcaagg ggacagccta 2160 cacgaacaca tagcgaacct agcggggagc ccggcgataa aaaaagggat actacaaacg 2220 gtaaaagtag tagacgaact agtaaaagta atggggcgac acaaaccgga aaacatagta 2280 atagaaatgg cgcgagaaaa ccaaacgacg caaaaagggc aaaaaaacag ccgagaacga 2340 atgaaacgaa tagaagaagg gataaaagaa ctagggagcc aaatactaaa agaacacccg 2400 gtagaaaaca cgcaactaca aaacgaaaaa ctatacctat actacctaca aaacgggcga 2460 gacatgtacg tagaccaaga actagacata aaccgactaa gcgactacga cgtagaccac 2520 atagtaccgc aaagcttcct aaaagacgac agcatagaca acaaagtact aacgcgaagc 2580 gacaaaaacc gagggaaaag cgacaacgta ccgagcgaag aagtagtaaa aaaaatgaaa 2640 aactactggc gacaactact aaacgcgaaa ctaataacgc aacgaaaatt cgacaaccta 2700 acgaaagcgg aacgaggggg gctaagcgaa ctagacaaag cggggttcat aaaacgacaa 2760 ctagtagaaa cgcgacaaat aacgaaacac gtagcgcaaa tactagacag ccgaatgaac 2820 acgaaatacg acgaaaacga caaactaata cgagaagtaa aagtaataac gctaaaaagc 2880 aaactagtaa gcgacttccg aaaagacttc caattctaca aagtacgaga aataaacaac 2940 taccaccacg cgcacgacgc gtacctaaac gcggtagtag ggacggcgct aataaaaaaa 3000 tacccgaaac tagaaagcga attcgtatac ggggactaca aagtatacga cgtacgaaaa 3060 atgatagcga aaagcgaaca agaaataggg aaagcgacgg cgaaatactt cttctacagc 3120 aacataatga acttcttcaa aacggaaata acgctagcga acggggaaat acgaaaacga 3180 ccgctaatag aaacgaacgg ggaaacgggg gaaatagtat gggacaaagg gcgagacttc 3240 gcgacggtac gaaaagtact aagcatgccg caagtaaaca tagtaaaaaa aacggaagta 3300 caaacggggg ggttcagcaa agaaagcata ctaccgaaac gaaacagcga caaactaata 3360 gcgcgaaaaa aagactggga cccgaaaaaa tacggggggt tcgacagccc gacggtagcg 3420 tacagcgtac tagtagtagc gaaagtagaa aaagggaaaa gcaaaaaact aaaaagcgta 3480 aaagaactac tagggataac gataatggaa cgaagcagct tcgaaaaaaa cccgatagac 3540 ttcctagaag cgaaagggta caaagaagta aaaaaagacc taataataaa actaccgaaa 3600 tacagcctat tcgaactaga aaacgggcga aaacgaatgc tagcgagcgc gggggaacta 3660 caaaaaggga acgaactagc gctaccgagc aaatacgtaa acttcctata cctagcgagc 3720 cactacgaaa aactaaaagg gagcccggaa gacaacgaac aaaaacaact attcgtagaa 3780 caacacaaac actacctaga cgaaataata gaacaaataa gcgaattcag caaacgagta 3840 atactagcgg acgcgaacct agacaaagta ctaagcgcgt acaacaaaca ccgagacaaa 3900 ccgatacgag aacaagcgga aaacataata cacctattca cgctaacgaa cctaggggcg 3960 ccggcggcgt tcaaatactt cgacacgacg atagaccgaa aacgatacac gagcacgaaa 4020 gaagtactag acgcgacgct aatacaccaa agcataacgg ggctatacga aacgcgaata 4080 gacctaagcc aactaggggg ggacgggggg gggagcccga aaaaaaaacg aaaagtatga 4140 <210> 55 <211> 4411 <212> ADN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 55 gggtcccgca gtcggcgtcc agcggctctg cttgttcgtg tgtgtgtcgt tgcaggcctt 60 attcggatcc gccaccatgg acaaaaaata cagcataggg ctagacatag ggacgaacag 120 cgtagggtgg gcggtaataa cggacgaata caaagtaccg agcaaaaaat tcaaagtact 180 agggaacacg gaccgacaca gcataaaaaa aaacctaata ggggcgctac tattcgacag 240 cggggaaacg gcggaagcga cgcgactaaa acgaacggcg cgacgacgat acacgcgacg 300 aaaaaaccga atatgctacc tacaagaaat attcagcaac gaaatggcga aagtagacga 360 cagcttcttc caccgactag aagaaagctt cctagtagaa gaagacaaaa aacacgaacg 420 acacccgata ttcgggaaca tagtagacga agtagcgtac cacgaaaaat acccgacgat 480 ataccaccta cgaaaaaaac tagtagacag cacggacaaa gcggacctac gactaatata 540 cctagcgcta gcgcacatga taaaattccg agggcacttc ctaatagaag gggacctaaa 600 cccggacaac agcgacgtag acaaactatt catacaacta gtacaaacgt acaaccaact 660 attcgaagaa aacccgataa acgcgagcgg ggtagacgcg aaagcgatac taagcgcgcg 720 actaagcaaa agccgacgac tagaaaacct aatagcgcaa ctaccggggg aaaaaaaaaa 780 cgggctattc gggaacctaa tagcgctaag cctagggcta acgccgaact tcaaaagcaa 840 cttcgaccta gcggaagacg cgaaactaca actaagcaaa gacacgtacg acgacgacct 900 agacaaccta ctagcgcaaa taggggacca atacgcggac ctattcctag cggcgaaaaa 960 cctaagcgac gcgatactac taagcgacat actacgagta aacacggaaa taacgaaagc 1020 gccgctaagc gcgagcatga taaaacgata cgacgaacac caccaagacc taacgctact 1080 aaaagcgcta gtacgacaac aactaccgga aaaatacaaa gaaatattct tcgaccaaag 1140 caaaaacggg tacgcggggt acatagacgg gggggcgagc caagaagaat tctacaaatt 1200 cataaaaccg atactagaaa aaatggacgg gacggaagaa ctactagtaa aactaaaccg 1260 agaagaccta ctacgaaaac aacgaacgtt cgacaacggg agcataccgc accaaataca 1320 cctaggggaa ctacacgcga tactacgacg acaagaagac ttctacccgt tcctaaaaga 1380 caaccgagaa aaaatagaaa aaatactaac gttccgaata ccgtactacg tagggccgct 1440 agcgcgaggg aacagccgat tcgcgtggat gacgcgaaaa agcgaagaaa cgataacgcc 1500 gtggaacttc gaagaagtag tagacaaagg ggcgagcgcg caaagcttca tagaacgaat 1560 gacgaacttc gacaaaaacc taccgaacga aaaagtacta ccgaaacaca gcctactata 1620 cgaatacttc acggtataca acgaactaac gaaagtaaaa tacgtaacgg aagggatgcg 1680 aaaaccggcg ttcctaagcg gggaacaaaa aaaagcgata gtagacctac tattcaaaac 1740 gaaccgaaaa gtaacggtaa aacaactaaa agaagactac ttcaaaaaaa tagaatgctt 1800 cgacagcgta gaaataagcg gggtagaaga ccgattcaac gcgagcctag ggacgtacca 1860 cgacctacta aaaataataa aagacaaaga cttcctagac aacgaagaaa acgaagacat 1920 actagaagac atagtactaa cgctaacgct attcgaagac cgagaaatga tagaagaacg 1980 actaaaaacg tacgcgcacc tattcgacga caaagtaatg aaacaactaa aacgacgacg 2040 atacacgggg tgggggcgac taagccgaaa actaataaac gggatacgag acaaacaaag 2100 cgggaaaacg atactagact tcctaaaaag cgacgggttc gcgaaccgaa acttcatgca 2160 actaatacac gacgacagcc taacgttcaa agaagacata caaaaagcgc aagtaagcgg 2220 gcaaggggac agcctacacg aacacatagc gaacctagcg gggagcccgg cgataaaaaa 2280 agggatacta caaacggtaa aagtagtaga cgaactagta aaagtaatgg ggcgacacaa 2340 accggaaaac atagtaatag aaatggcgcg agaaaaccaa acgacgcaaa aagggcaaaa 2400 aaacagccga gaacgaatga aacgaataga agaagggata aaagaactag ggagccaaat 2460 actaaaagaa cacccggtag aaaacacgca actacaaaac gaaaaactat acctatacta 2520 cctacaaaac gggcgagaca tgtacgtaga ccaagaacta gacataaacc gactaagcga 2580 ctacgacgta gaccacatag taccgcaaag cttcctaaaa gacgacagca tagacaacaa 2640 agtactaacg cgaagcgaca aaaaccgagg gaaaagcgac aacgtaccga gcgaagaagt 2700 agtaaaaaaa atgaaaaact actggcgaca actactaaac gcgaaactaa taacgcaacg 2760 aaaattcgac aacctaacga aagcggaacg aggggggcta agcgaactag acaaagcggg 2820 gttcataaaa cgacaactag tagaaacgcg acaaataacg aaacacgtag cgcaaatact 2880 agacagccga atgaacacga aatacgacga aaacgacaaa ctaatacgag aagtaaaagt 2940 aataacgcta aaaagcaaac tagtaagcga cttccgaaaa gacttccaat tctacaaagt 3000 acgagaaata aacaactacc accacgcgca cgacgcgtac ctaaacgcgg tagtagggac 3060 ggcgctaata aaaaaatacc cgaaactaga aagcgaattc gtatacgggg actacaaagt 3120 atacgacgta cgaaaaatga tagcgaaaag cgaacaagaa atagggaaag cgacggcgaa 3180 atacttcttc tacagcaaca taatgaactt cttcaaaacg gaaataacgc tagcgaacgg 3240 ggaaatacga aaacgaccgc taatagaaac gaacggggaa acgggggaaa tagtatggga 3300 caaagggcga gacttcgcga cggtacgaaa agtactaagc atgccgcaag taaacatagt 3360 aaaaaaaacg gaagtacaaa cgggggggtt cagcaaagaa agcatactac cgaaacgaaa 3420 cagcgacaaa ctaatagcgc gaaaaaaaga ctgggacccg aaaaaatacg gggggttcga 3480 cagcccgacg gtagcgtaca gcgtactagt agtagcgaaa gtagaaaaag ggaaaagcaa 3540 aaaactaaaa agcgtaaaag aactactagg gataacgata atggaacgaa gcagcttcga 3600 aaaaaacccg atagacttcc tagaagcgaa agggtacaaa gaagtaaaaa aagacctaat 3660 aataaaacta ccgaaataca gcctattcga actagaaaac gggcgaaaac gaatgctagc 3720 gagcgcgggg gaactacaaa aagggaacga actagcgcta ccgagcaaat acgtaaactt 3780 cctataccta gcgagccact acgaaaaact aaaagggagc ccggaagaca acgaacaaaa 3840 acaactattc gtagaacaac acaaacacta cctagacgaa ataatagaac aaataagcga 3900 attcagcaaa cgagtaatac tagcggacgc gaacctagac aaagtactaa gcgcgtacaa 3960 caaacaccga gacaaaccga tacgagaaca agcggaaaac ataatacacc tattcacgct 4020 aacgaaccta ggggcgccgg cggcgttcaa atacttcgac acgacgatag accgaaaacg 4080 atacacgagc acgaaagaag tactagacgc gacgctaata caccaaagca taacggggct 4140 atacgaaacg cgaatagacc taagccaact agggggggac ggggggggga gcccgaaaaa 4200 aaaacgaaaa gtatgactag ccatcacatt taaaagcatc tcagcctacc atgagaataa 4260 gagaaagaaa atgaagatca atagcttatt catctctttt tctttttcgt tggtgtaaag 4320 ccaacaccct gtctaaaaaa cataaatttc tttaatcatt ttgcctcttt tctctgtgct 4380 tcaattaata aaaaatggaa agaacctcga g 4411 <210> 56 <211> 4411 <212> ADN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 56 aggtcccgca gtcggcgtcc agcggctctg cttgttcgtg tgtgtgtcgt tgcaggcctt 60 attcggatcc gccaccatgg acaagaagta cagcatcgga ctggacatcg gaacaaacag 120 cgtcggatgg gcagtcatca cagacgaata caaggtcccg agcaagaagt tcaaggtcct 180 gggaaacaca gacagacaca gcatcaagaa gaacctgatc ggagcactgc tgttcgacag 240 cggagaaaca gcagaagcaa caagactgaa gagaacagca agaagaagat acacaagaag 300 aaagaacaga atctgctacc tgcaggaaat cttcagcaac gaaatggcaa aggtcgacga 360 cagcttcttc cacagactgg aagaaagctt cctggtcgaa gaagacaaga agcacgaaag 420 acacccgatc ttcggaaaca tcgtcgacga agtcgcatac cacgaaaagt acccgacaat 480 ctaccacctg agaaagaagc tggtcgacag cacagacaag gcagacctga gactgatcta 540 cctggcactg gcacacatga tcaagttcag aggacacttc ctgatcgaag gagacctgaa 600 cccggacaac agcgacgtcg acaagctgtt catccagctg gtccagacat acaaccagct 660 gttcgaagaa aacccgatca acgcaagcgg agtcgacgca aaggcaatcc tgagcgcaag 720 actgagcaag agcagaagac tggaaaacct gatcgcacag ctgccgggag aaaagaagaa 780 cggactgttc ggaaacctga tcgcactgag cctgggactg acaccgaact tcaagagcaa 840 cttcgacctg gcagaagacg caaagctgca gctgagcaag gacacatacg acgacgacct 900 ggacaacctg ctggcacaga tcggagacca gtacgcagac ctgttcctgg cagcaaagaa 960 cctgagcgac gcaatcctgc tgagcgacat cctgagagtc aacacagaaa tcacaaaggc 1020 accgctgagc gcaagcatga tcaagagata cgacgaacac caccaggacc tgacactgct 1080 gaaggcactg gtcagacagc agctgccgga aaagtacaag gaaatcttct tcgaccagag 1140 caagaacgga tacgcaggat acatcgacgg aggagcaagc caggaagaat tctacaagtt 1200 catcaagccg atcctggaaa agatggacgg aacagaagaa ctgctggtca agctgaacag 1260 agaagacctg ctgagaaagc agagaacatt cgacaacgga agcatcccgc accagatcca 1320 cctgggagaa ctgcacgcaa tcctgagaag acaggaagac ttctacccgt tcctgaagga 1380 caacagagaa aagatcgaaa agatcctgac attcagaatc ccgtactacg tcggaccgct 1440 ggcaagagga aacagcagat tcgcatggat gacaagaaag agcgaagaaa caatcacacc 1500 gtggaacttc gaagaagtcg tcgacaaggg agcaagcgca cagagcttca tcgaaagaat 1560 gacaaacttc gacaagaacc tgccgaacga aaaggtcctg ccgaagcaca gcctgctgta 1620 cgaatacttc acagtctaca acgaactgac aaaggtcaag tacgtcacag aaggaatgag 1680 aaagccggca ttcctgagcg gagaacagaa gaaggcaatc gtcgacctgc tgttcaagac 1740 aaacagaaag gtcacagtca agcagctgaa ggaagactac ttcaagaaga tcgaatgctt 1800 cgacagcgtc gaaatcagcg gagtcgaaga cagattcaac gcaagcctgg gaacatacca 1860 cgacctgctg aagatcatca aggacaagga cttcctggac aacgaagaaa acgaagacat 1920 cctggaagac atcgtcctga cactgacact gttcgaagac agagaaatga tcgaagaaag 1980 actgaagaca tacgcacacc tgttcgacga caaggtcatg aagcagctga agagaagaag 2040 atacacagga tggggaagac tgagcagaaa gctgatcaac ggaatcagag acaagcagag 2100 cggaaagaca atcctggact tcctgaagag cgacggattc gcaaacagaa acttcatgca 2160 gctgatccac gacgacagcc tgacattcaa ggaagacatc cagaaggcac aggtcagcgg 2220 acagggagac agcctgcacg aacacatcgc aaacctggca ggaagcccgg caatcaagaa 2280 gggaatcctg cagacagtca aggtcgtcga cgaactggtc aaggtcatgg gaagacacaa 2340 gccggaaaac atcgtcatcg aaatggcaag agaaaaccag acaacacaga agggacagaa 2400 gaacagcaga gaaagaatga agagaatcga agaaggaatc aaggaactgg gaagccagat 2460 cctgaaggaa cacccggtcg aaaacacaca gctgcagaac gaaaagctgt acctgtacta 2520 cctgcagaac ggaagagaca tgtacgtcga ccaggaactg gacatcaaca gactgagcga 2580 ctacgacgtc gaccacatcg tcccgcagag cttcctgaag gacgacagca tcgacaacaa 2640 ggtcctgaca agaagcgaca agaacagagg aaagagcgac aacgtcccga gcgaagaagt 2700 cgtcaagaag atgaagaact actggagaca gctgctgaac gcaaagctga tcacacagag 2760 aaagttcgac aacctgacaa aggcagagag aggaggactg agcgaactgg acaaggcagg 2820 attcatcaag agacagctgg tcgaaacaag acagatcaca aagcacgtcg cacagatcct 2880 ggacagcaga atgaacacaa agtacgacga aaacgacaag ctgatcagag aagtcaaggt 2940 catcacactg aagagcaagc tggtcagcga cttcagaaag gacttccagt tctacaaggt 3000 cagagaaatc aacaactacc accacgcaca cgacgcatac ctgaacgcag tcgtcggaac 3060 agcactgatc aagaagtacc cgaagctgga aagcgaattc gtctacggag actacaaggt 3120 ctacgacgtc agaaagatga tcgcaaagag cgaacaggaa atcggaaagg caacagcaaa 3180 gtacttcttc tacagcaaca tcatgaactt cttcaagaca gaaatcacac tggcaaacgg 3240 agaaatcaga aagagaccgc tgatcgaaac aaacggagaa acaggagaaa tcgtctggga 3300 caagggaaga gacttcgcaa cagtcagaaa ggtcctgagc atgccgcagg tcaacatcgt 3360 caagaagaca gaagtccaga caggaggatt cagcaaggaa agcatcctgc cgaagagaaa 3420 cagcgacaag ctgatcgcaa gaaagaagga ctgggacccg aagaagtacg gaggattcga 3480 cagcccgaca gtcgcataca gcgtcctggt cgtcgcaaag gtcgaaaagg gaaagagcaa 3540 gaagctgaag agcgtcaagg aactgctggg aatcacaatc atggaaagaa gcagcttcga 3600 aaagaacccg atcgacttcc tggaagcaaa gggatacaag gaagtcaaga aggacctgat 3660 catcaagctg ccgaagtaca gcctgttcga actggaaaac ggaagaaaga gaatgctggc 3720 aagcgcagga gaactgcaga agggaaacga actggcactg ccgagcaagt acgtcaactt 3780 cctgtacctg gcaagccact acgaaaagct gaagggaagc ccggaagaca acgaacagaa 3840 gcagctgttc gtcgaacagc acaagcacta cctggacgaa atcatcgaac agatcagcga 3900 attcagcaag agagtcatcc tggcagacgc aaacctggac aaggtcctga gcgcatacaa 3960 caagcacaga gacaagccga tcagagaaca ggcagaaaac atcatccacc tgttcacact 4020 gacaaacctg ggagcaccgg cagcattcaa gtacttcgac acaacaatcg acagaaagag 4080 atacacaagc acaaaggaag tcctggacgc aacactgatc caccagagca tcacaggact 4140 gtacgaaaca agaatcgacc tgagccagct gggaggagac ggaggaggaa gcccgaagaa 4200 gaagagaaag gtctagctag ccatcacatt taaaagcatc tcagcctacc atgagaataa 4260 gagaaagaaa atgaagatca atagcttatt catctctttt tctttttcgt tggtgtaaag 4320 ccaacaccct gtctaaaaaa cataaatttc tttaatcatt ttgcctcttt tctctgtgct 4380 tcaattaata aaaaatggaa agaacctcga g 4411 <210> 57 <211> 4481 <212> ADN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 57 gggcagatcg cctggagacg ccatccacgc tgttttgacc tccatagaag acaccgggac 60 cgatccagcc tccgcggccg ggaacggtgc attggaacgc ggattccccg tgccaagagt 120 gactcaccgt ccttgacacg gccaccatgg acaagaagta cagcatcgga ctggacatcg 180 gaacaaacag cgtcggatgg gcagtcatca cagacgaata caaggtcccg agcaagaagt 240 tcaaggtcct gggaaacaca gacagacaca gcatcaagaa gaacctgatc ggagcactgc 300 tgttcgacag cggagaaaca gcagaagcaa caagactgaa gagaacagca agaagaagat 360 acacaagaag aaagaacaga atctgctacc tgcaggaaat cttcagcaac gaaatggcaa 420 aggtcgacga cagcttcttc cacagactgg aagaaagctt cctggtcgaa gaagacaaga 480 agcacgaaag acacccgatc ttcggaaaca tcgtcgacga agtcgcatac cacgaaaagt 540 acccgacaat ctaccacctg agaaagaagc tggtcgacag cacagacaag gcagacctga 600 gactgatcta cctggcactg gcacacatga tcaagttcag aggacacttc ctgatcgaag 660 gagacctgaa cccggacaac agcgacgtcg acaagctgtt catccagctg gtccagacat 720 acaaccagct gttcgaagaa aacccgatca acgcaagcgg agtcgacgca aaggcaatcc 780 tgagcgcaag actgagcaag agcagaagac tggaaaacct gatcgcacag ctgccgggag 840 aaaagaagaa cggactgttc ggaaacctga tcgcactgag cctgggactg acaccgaact 900 tcaagagcaa cttcgacctg gcagaagacg caaagctgca gctgagcaag gacacatacg 960 acgacgacct ggacaacctg ctggcacaga tcggagacca gtacgcagac ctgttcctgg 1020 cagcaaagaa cctgagcgac gcaatcctgc tgagcgacat cctgagagtc aacacagaaa 1080 tcacaaaggc accgctgagc gcaagcatga tcaagagata cgacgaacac caccaggacc 1140 tgacactgct gaaggcactg gtcagacagc agctgccgga aaagtacaag gaaatcttct 1200 tcgaccagag caagaacgga tacgcaggat acatcgacgg aggagcaagc caggaagaat 1260 tctacaagtt catcaagccg atcctggaaa agatggacgg aacagaagaa ctgctggtca 1320 agctgaacag agaagacctg ctgagaaagc agagaacatt cgacaacgga agcatcccgc 1380 accagatcca cctgggagaa ctgcacgcaa tcctgagaag acaggaagac ttctacccgt 1440 tcctgaagga caacagagaa aagatcgaaa agatcctgac attcagaatc ccgtactacg 1500 tcggaccgct ggcaagagga aacagcagat tcgcatggat gacaagaaag agcgaagaaa 1560 caatcacacc gtggaacttc gaagaagtcg tcgacaaggg agcaagcgca cagagcttca 1620 tcgaaagaat gacaaacttc gacaagaacc tgccgaacga aaaggtcctg ccgaagcaca 1680 gcctgctgta cgaatacttc acagtctaca acgaactgac aaaggtcaag tacgtcacag 1740 aaggaatgag aaagccggca ttcctgagcg gagaacagaa gaaggcaatc gtcgacctgc 1800 tgttcaagac aaacagaaag gtcacagtca agcagctgaa ggaagactac ttcaagaaga 1860 tcgaatgctt cgacagcgtc gaaatcagcg gagtcgaaga cagattcaac gcaagcctgg 1920 gaacatacca cgacctgctg aagatcatca aggacaagga cttcctggac aacgaagaaa 1980 acgaagacat cctggaagac atcgtcctga cactgacact gttcgaagac agagaaatga 2040 tcgaagaaag actgaagaca tacgcacacc tgttcgacga caaggtcatg aagcagctga 2100 agagaagaag atacacagga tggggaagac tgagcagaaa gctgatcaac ggaatcagag 2160 acaagcagag cggaaagaca atcctggact tcctgaagag cgacggattc gcaaacagaa 2220 acttcatgca gctgatccac gacgacagcc tgacattcaa ggaagacatc cagaaggcac 2280 aggtcagcgg acagggagac agcctgcacg aacacatcgc aaacctggca ggaagcccgg 2340 caatcaagaa gggaatcctg cagacagtca aggtcgtcga cgaactggtc aaggtcatgg 2400 gaagacacaa gccggaaaac atcgtcatcg aaatggcaag agaaaaccag acaacacaga 2460 agggacagaa gaacagcaga gaaagaatga agagaatcga agaaggaatc aaggaactgg 2520 gaagccagat cctgaaggaa cacccggtcg aaaacacaca gctgcagaac gaaaagctgt 2580 acctgtacta cctgcagaac ggaagagaca tgtacgtcga ccaggaactg gacatcaaca 2640 gactgagcga ctacgacgtc gaccacatcg tcccgcagag cttcctgaag gacgacagca 2700 tcgacaacaa ggtcctgaca agaagcgaca agaacagagg aaagagcgac aacgtcccga 2760 gcgaagaagt cgtcaagaag atgaagaact actggagaca gctgctgaac gcaaagctga 2820 tcacacagag aaagttcgac aacctgacaa aggcagagag aggaggactg agcgaactgg 2880 acaaggcagg attcatcaag agacagctgg tcgaaacaag acagatcaca aagcacgtcg 2940 cacagatcct ggacagcaga atgaacacaa agtacgacga aaacgacaag ctgatcagag 3000 aagtcaaggt catcacactg aagagcaagc tggtcagcga cttcagaaag gacttccagt 3060 tctacaaggt cagagaaatc aacaactacc accacgcaca cgacgcatac ctgaacgcag 3120 tcgtcggaac agcactgatc aagaagtacc cgaagctgga aagcgaattc gtctacggag 3180 actacaaggt ctacgacgtc agaaagatga tcgcaaagag cgaacaggaa atcggaaagg 3240 caacagcaaa gtacttcttc tacagcaaca tcatgaactt cttcaagaca gaaatcacac 3300 tggcaaacgg agaaatcaga aagagaccgc tgatcgaaac aaacggagaa acaggagaaa 3360 tcgtctggga caagggaaga gacttcgcaa cagtcagaaa ggtcctgagc atgccgcagg 3420 tcaacatcgt caagaagaca gaagtccaga caggaggatt cagcaaggaa agcatcctgc 3480 cgaagagaaa cagcgacaag ctgatcgcaa gaaagaagga ctgggacccg aagaagtacg 3540 gaggattcga cagcccgaca gtcgcataca gcgtcctggt cgtcgcaaag gtcgaaaagg 3600 gaaagagcaa gaagctgaag agcgtcaagg aactgctggg aatcacaatc atggaaagaa 3660 gcagcttcga aaagaacccg atcgacttcc tggaagcaaa gggatacaag gaagtcaaga 3720 aggacctgat catcaagctg ccgaagtaca gcctgttcga actggaaaac ggaagaaaga 3780 gaatgctggc aagcgcagga gaactgcaga agggaaacga actggcactg ccgagcaagt 3840 acgtcaactt cctgtacctg gcaagccact acgaaaagct gaagggaagc ccggaagaca 3900 acgaacagaa gcagctgttc gtcgaacagc acaagcacta cctggacgaa atcatcgaac 3960 agatcagcga attcagcaag agagtcatcc tggcagacgc aaacctggac aaggtcctga 4020 gcgcatacaa caagcacaga gacaagccga tcagagaaca ggcagaaaac atcatccacc 4080 tgttcacact gacaaacctg ggagcaccgg cagcattcaa gtacttcgac acaacaatcg 4140 acagaaagag atacacaagc acaaaggaag tcctggacgc aacactgatc caccagagca 4200 tcacaggact gtacgaaaca agaatcgacc tgagccagct gggaggagac ggaggaggaa 4260 gcccgaagaa gaagagaaag gtctagctag ccatcacatt taaaagcatc tcagcctacc 4320 atgagaataa gagaaagaaa atgaagatca atagcttatt catctctttt tctttttcgt 4380 tggtgtaaag ccaacaccct gtctaaaaaa cataaatttc tttaatcatt ttgcctcttt 4440 tctctgtgct tcaattaata aaaaatggaa agaacctcga g 4481 <210> 58 <211> 4348 <212> ADN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 58 gggacatttg cttctgacac aactgtgttc actagcaacc tcaaacagac accggatctg 60 ccaccatgga caagaagtac agcatcggac tggacatcgg aacaaacagc gtcggatggg 120 cagtcatcac agacgaatac aaggtcccga gcaagaagtt caaggtcctg ggaaacacag 180 acagacacag catcaagaag aacctgatcg gagcactgct gttcgacagc ggagaaacag 240 cagaagcaac aagactgaag agaacagcaa gaagaagata cacaagaaga aagaacagaa 300 tctgctacct gcaggaaatc ttcagcaacg aaatggcaaa ggtcgacgac agcttcttcc 360 acagactgga agaaagcttc ctggtcgaag aagacaagaa gcacgaaaga cacccgatct 420 tcggaaacat cgtcgacgaa gtcgcatacc acgaaaagta cccgacaatc taccacctga 480 gaaagaagct ggtcgacagc acagacaagg cagacctgag actgatctac ctggcactgg 540 cacacatgat caagttcaga ggacacttcc tgatcgaagg agacctgaac ccggacaaca 600 gcgacgtcga caagctgttc atccagctgg tccagacata caaccagctg ttcgaagaaa 660 acccgatcaa cgcaagcgga gtcgacgcaa aggcaatcct gagcgcaaga ctgagcaaga 720 gcagaagact ggaaaacctg atcgcacagc tgccgggaga aaagaagaac ggactgttcg 780 gaaacctgat cgcactgagc ctgggactga caccgaactt caagagcaac ttcgacctgg 840 cagaagacgc aaagctgcag ctgagcaagg acacatacga cgacgacctg gacaacctgc 900 tggcacagat cggagaccag tacgcagacc tgttcctggc agcaaagaac ctgagcgacg 960 caatcctgct gagcgacatc ctgagagtca acacagaaat cacaaaggca ccgctgagcg 1020 caagcatgat caagagatac gacgaacacc accaggacct gacactgctg aaggcactgg 1080 tcagacagca gctgccggaa aagtacaagg aaatcttctt cgaccagagc aagaacggat 1140 acgcaggata catcgacgga ggagcaagcc aggaagaatt ctacaagttc atcaagccga 1200 tcctggaaaa gatggacgga acagaagaac tgctggtcaa gctgaacaga gaagacctgc 1260 tgagaaagca gagaacattc gacaacggaa gcatcccgca ccagatccac ctgggagaac 1320 tgcacgcaat cctgagaaga caggaagact tctacccgtt cctgaaggac aacagagaaa 1380 agatcgaaaa gatcctgaca ttcagaatcc cgtactacgt cggaccgctg gcaagaggaa 1440 acagcagatt cgcatggatg acaagaaaga gcgaagaaac aatcacaccg tggaacttcg 1500 aagaagtcgt cgacaaggga gcaagcgcac agagcttcat cgaaagaatg acaaacttcg 1560 acaagaacct gccgaacgaa aaggtcctgc cgaagcacag cctgctgtac gaatacttca 1620 cagtctacaa cgaactgaca aaggtcaagt acgtcacaga aggaatgaga aagccggcat 1680 tcctgagcgg agaacagaag aaggcaatcg tcgacctgct gttcaagaca aacagaaagg 1740 tcacagtcaa gcagctgaag gaagactact tcaagaagat cgaatgcttc gacagcgtcg 1800 aaatcagcgg agtcgaagac agattcaacg caagcctggg aacataccac gacctgctga 1860 agatcatcaa ggacaaggac ttcctggaca acgaagaaaa cgaagacatc ctggaagaca 1920 tcgtcctgac actgacactg ttcgaagaca gagaaatgat cgaagaaaga ctgaagacat 1980 acgcacacct gttcgacgac aaggtcatga agcagctgaa gagaagaaga tacacaggat 2040 ggggaagact gagcagaaag ctgatcaacg gaatcagaga caagcagagc ggaaagacaa 2100 tcctggactt cctgaagagc gacggattcg caaacagaaa cttcatgcag ctgatccacg 2160 acgacagcct gacattcaag gaagacatcc agaaggcaca ggtcagcgga cagggagaca 2220 gcctgcacga acacatcgca aacctggcag gaagcccggc aatcaagaag ggaatcctgc 2280 agacagtcaa ggtcgtcgac gaactggtca aggtcatggg aagacacaag ccggaaaaca 2340 tcgtcatcga aatggcaaga gaaaaccaga caacacagaa gggacagaag aacagcagag 2400 aaagaatgaa gagaatcgaa gaaggaatca aggaactggg aagccagatc ctgaaggaac 2460 acccggtcga aaacacacag ctgcagaacg aaaagctgta cctgtactac ctgcagaacg 2520 gaagagacat gtacgtcgac caggaactgg acatcaacag actgagcgac tacgacgtcg 2580 accacatcgt cccgcagagc ttcctgaagg acgacagcat cgacaacaag gtcctgacaa 2640 gaagcgacaa gaacagagga aagagcgaca acgtcccgag cgaagaagtc gtcaagaaga 2700 tgaagaacta ctggagacag ctgctgaacg caaagctgat cacacagaga aagttcgaca 2760 acctgacaaa ggcagagaga ggaggactga gcgaactgga caaggcagga ttcatcaaga 2820 gacagctggt cgaaacaaga cagatcacaa agcacgtcgc acagatcctg gacagcagaa 2880 tgaacacaaa gtacgacgaa aacgacaagc tgatcagaga agtcaaggtc atcacactga 2940 agagcaagct ggtcagcgac ttcagaaagg acttccagtt ctacaaggtc agagaaatca 3000 acaactacca ccacgcacac gacgcatacc tgaacgcagt cgtcggaaca gcactgatca 3060 agaagtaccc gaagctggaa agcgaattcg tctacggaga ctacaaggtc tacgacgtca 3120 gaaagatgat cgcaaagagc gaacaggaaa tcggaaaggc aacagcaaag tacttcttct 3180 acagcaacat catgaacttc ttcaagacag aaatcacact ggcaaacgga gaaatcagaa 3240 agagaccgct gatcgaaaca aacggagaaa caggagaaat cgtctgggac aagggaagag 3300 acttcgcaac agtcagaaag gtcctgagca tgccgcaggt caacatcgtc aagaagacag 3360 aagtccagac aggaggattc agcaaggaaa gcatcctgcc gaagagaaac agcgacaagc 3420 tgatcgcaag aaagaaggac tgggacccga agaagtacgg aggattcgac agcccgacag 3480 tcgcatacag cgtcctggtc gtcgcaaagg tcgaaaaggg aaagagcaag aagctgaaga 3540 gcgtcaagga actgctggga atcacaatca tggaaagaag cagcttcgaa aagaacccga 3600 tcgacttcct ggaagcaaag ggatacaagg aagtcaagaa ggacctgatc atcaagctgc 3660 cgaagtacag cctgttcgaa ctggaaaacg gaagaaagag aatgctggca agcgcaggag 3720 aactgcagaa gggaaacgaa ctggcactgc cgagcaagta cgtcaacttc ctgtacctgg 3780 caagccacta cgaaaagctg aagggaagcc cggaagacaa cgaacagaag cagctgttcg 3840 tcgaacagca caagcactac ctggacgaaa tcatcgaaca gatcagcgaa ttcagcaaga 3900 gagtcatcct ggcagacgca aacctggaca aggtcctgag cgcatacaac aagcacagag 3960 acaagccgat cagagaacag gcagaaaaca tcatccacct gttcacactg acaaacctgg 4020 gagcaccggc agcattcaag tacttcgaca caacaatcga cagaaagaga tacacaagca 4080 caaaggaagt cctggacgca acactgatcc accagagcat cacaggactg tacgaaacaa 4140 gaatcgacct gagccagctg ggaggagacg gaggaggaag cccgaagaag aagagaaagg 4200 tctagctagc gctcgctttc ttgctgtcca atttctatta aaggttcctt tgttccctaa 4260 gtccaactac taaactgggg gatattatga agggccttga gcatctggat tctgcctaat 4320 aaaaaacatt tattttcatt gcctcgag 4348 <210> 59 <211> 4325 <212> ADN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 59 gggaagctca gaataaacgc tcaactttgg ccggatctgc caccatggac aagaagtaca 60 gcatcggact ggacatcgga acaaacagcg tcggatgggc agtcatcaca gacgaataca 120 aggtcccgag caagaagttc aaggtcctgg gaaacacaga cagacacagc atcaagaaga 180 acctgatcgg agcactgctg ttcgacagcg gagaaacagc agaagcaaca agactgaaga 240 gaacagcaag aagaagatac acaagaagaa agaacagaat ctgctacctg caggaaatct 300 tcagcaacga aatggcaaag gtcgacgaca gcttcttcca cagactggaa gaaagcttcc 360 tggtcgaaga agacaagaag cacgaaagac acccgatctt cggaaacatc gtcgacgaag 420 tcgcatacca cgaaaagtac ccgacaatct accacctgag aaagaagctg gtcgacagca 480 cagacaaggc agacctgaga ctgatctacc tggcactggc acacatgatc aagttcagag 540 gacacttcct gatcgaagga gacctgaacc cggacaacag cgacgtcgac aagctgttca 600 tccagctggt ccagacatac aaccagctgt tcgaagaaaa cccgatcaac gcaagcggag 660 tcgacgcaaa ggcaatcctg agcgcaagac tgagcaagag cagaagactg gaaaacctga 720 tcgcacagct gccgggagaa aagaagaacg gactgttcgg aaacctgatc gcactgagcc 780 tgggactgac accgaacttc aagagcaact tcgacctggc agaagacgca aagctgcagc 840 tgagcaagga cacatacgac gacgacctgg acaacctgct ggcacagatc ggagaccagt 900 acgcagacct gttcctggca gcaaagaacc tgagcgacgc aatcctgctg agcgacatcc 960 tgagagtcaa cacagaaatc acaaaggcac cgctgagcgc aagcatgatc aagagatacg 1020 acgaacacca ccaggacctg acactgctga aggcactggt cagacagcag ctgccggaaa 1080 agtacaagga aatcttcttc gaccagagca agaacggata cgcaggatac atcgacggag 1140 gagcaagcca ggaagaattc tacaagttca tcaagccgat cctggaaaag atggacggaa 1200 cagaagaact gctggtcaag ctgaacagag aagacctgct gagaaagcag agaacattcg 1260 acaacggaag catcccgcac cagatccacc tgggagaact gcacgcaatc ctgagaagac 1320 aggaagactt ctacccgttc ctgaaggaca acagagaaaa gatcgaaaag atcctgacat 1380 tcagaatccc gtactacgtc ggaccgctgg caagaggaaa cagcagattc gcatggatga 1440 caagaaagag cgaagaaaca atcacaccgt ggaacttcga agaagtcgtc gacaagggag 1500 caagcgcaca gagcttcatc gaaagaatga caaacttcga caagaacctg ccgaacgaaa 1560 aggtcctgcc gaagcacagc ctgctgtacg aatacttcac agtctacaac gaactgacaa 1620 aggtcaagta cgtcacagaa ggaatgagaa agccggcatt cctgagcgga gaacagaaga 1680 aggcaatcgt cgacctgctg ttcaagacaa acagaaaggt cacagtcaag cagctgaagg 1740 aagactactt caagaagatc gaatgcttcg acagcgtcga aatcagcgga gtcgaagaca 1800 gattcaacgc aagcctggga acataccacg acctgctgaa gatcatcaag gacaaggact 1860 tcctggacaa cgaagaaaac gaagacatcc tggaagacat cgtcctgaca ctgacactgt 1920 tcgaagacag agaaatgatc gaagaaagac tgaagacata cgcacacctg ttcgacgaca 1980 aggtcatgaa gcagctgaag agaagaagat acacaggatg gggaagactg agcagaaagc 2040 tgatcaacgg aatcagagac aagcagagcg gaaagacaat cctggacttc ctgaagagcg 2100 acggattcgc aaacagaaac ttcatgcagc tgatccacga cgacagcctg acattcaagg 2160 aagacatcca gaaggcacag gtcagcggac agggagacag cctgcacgaa cacatcgcaa 2220 acctggcagg aagcccggca atcaagaagg gaatcctgca gacagtcaag gtcgtcgacg 2280 aactggtcaa ggtcatggga agacacaagc cggaaaacat cgtcatcgaa atggcaagag 2340 aaaaccagac aacacagaag ggacagaaga acagcagaga aagaatgaag agaatcgaag 2400 aaggaatcaa ggaactggga agccagatcc tgaaggaaca cccggtcgaa aacacacagc 2460 tgcagaacga aaagctgtac ctgtactacc tgcagaacgg aagagacatg tacgtcgacc 2520 aggaactgga catcaacaga ctgagcgact acgacgtcga ccacatcgtc ccgcagagct 2580 tcctgaagga cgacagcatc gacaacaagg tcctgacaag aagcgacaag aacagaggaa 2640 agagcgacaa cgtcccgagc gaagaagtcg tcaagaagat gaagaactac tggagacagc 2700 tgctgaacgc aaagctgatc acacagagaa agttcgacaa cctgacaaag gcagagagag 2760 gaggactgag cgaactggac aaggcaggat tcatcaagag acagctggtc gaaacaagac 2820 agatcacaaa gcacgtcgca cagatcctgg acagcagaat gaacacaaag tacgacgaaa 2880 acgacaagct gatcagagaa gtcaaggtca tcacactgaa gagcaagctg gtcagcgact 2940 tcagaaagga cttccagttc tacaaggtca gagaaatcaa caactaccac cacgcacacg 3000 acgcatacct gaacgcagtc gtcggaacag cactgatcaa gaagtacccg aagctggaaa 3060 gcgaattcgt ctacggagac tacaaggtct acgacgtcag aaagatgatc gcaaagagcg 3120 aacaggaaat cggaaaggca acagcaaagt acttcttcta cagcaacatc atgaacttct 3180 tcaagacaga aatcacactg gcaaacggag aaatcagaaa gagaccgctg atcgaaacaa 3240 acggagaaac aggagaaatc gtctgggaca agggaagaga cttcgcaaca gtcagaaagg 3300 tcctgagcat gccgcaggtc aacatcgtca agaagacaga agtccagaca ggaggattca 3360 gcaaggaaag catcctgccg aagagaaaca gcgacaagct gatcgcaaga aagaaggact 3420 gggacccgaa gaagtacgga ggattcgaca gcccgacagt cgcatacagc gtcctggtcg 3480 tcgcaaaggt cgaaaaggga aagagcaaga agctgaagag cgtcaaggaa ctgctgggaa 3540 tcacaatcat ggaaagaagc agcttcgaaa agaacccgat cgacttcctg gaagcaaagg 3600 gatacaagga agtcaagaag gacctgatca tcaagctgcc gaagtacagc ctgttcgaac 3660 tggaaaacgg aagaaagaga atgctggcaa gcgcaggaga actgcagaag ggaaacgaac 3720 tggcactgcc gagcaagtac gtcaacttcc tgtacctggc aagccactac gaaaagctga 3780 agggaagccc ggaagacaac gaacagaagc agctgttcgt cgaacagcac aagcactacc 3840 tggacgaaat catcgaacag atcagcgaat tcagcaagag agtcatcctg gcagacgcaa 3900 acctggacaa ggtcctgagc gcatacaaca agcacagaga caagccgatc agagaacagg 3960 cagaaaacat catccacctg ttcacactga caaacctggg agcaccggca gcattcaagt 4020 acttcgacac aacaatcgac agaaagagat acacaagcac aaaggaagtc ctggacgcaa 4080 cactgatcca ccagagcatc acaggactgt acgaaacaag aatcgacctg agccagctgg 4140 gaggagacgg aggaggaagc ccgaagaaga agagaaaggt ctagctagca ccagcctcaa 4200 gaacacccga atggagtctc taagctacat aataccaact tacactttac aaaatgttgt 4260 cccccaaaat gtagccattc gtatctgctc ctaataaaaa gaaagtttct tcacattctc 4320 tcgag 4325 <210> 60 <211> 4325 <212> ADN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 60 aggaagctca gaataaacgc tcaactttgg ccggatctgc caccatggac aagaagtaca 60 gcatcggact ggacatcgga acaaacagcg tcggatgggc agtcatcaca gacgaataca 120 aggtcccgag caagaagttc aaggtcctgg gaaacacaga cagacacagc atcaagaaga 180 acctgatcgg agcactgctg ttcgacagcg gagaaacagc agaagcaaca agactgaaga 240 gaacagcaag aagaagatac acaagaagaa agaacagaat ctgctacctg caggaaatct 300 tcagcaacga aatggcaaag gtcgacgaca gcttcttcca cagactggaa gaaagcttcc 360 tggtcgaaga agacaagaag cacgaaagac acccgatctt cggaaacatc gtcgacgaag 420 tcgcatacca cgaaaagtac ccgacaatct accacctgag aaagaagctg gtcgacagca 480 cagacaaggc agacctgaga ctgatctacc tggcactggc acacatgatc aagttcagag 540 gacacttcct gatcgaagga gacctgaacc cggacaacag cgacgtcgac aagctgttca 600 tccagctggt ccagacatac aaccagctgt tcgaagaaaa cccgatcaac gcaagcggag 660 tcgacgcaaa ggcaatcctg agcgcaagac tgagcaagag cagaagactg gaaaacctga 720 tcgcacagct gccgggagaa aagaagaacg gactgttcgg aaacctgatc gcactgagcc 780 tgggactgac accgaacttc aagagcaact tcgacctggc agaagacgca aagctgcagc 840 tgagcaagga cacatacgac gacgacctgg acaacctgct ggcacagatc ggagaccagt 900 acgcagacct gttcctggca gcaaagaacc tgagcgacgc aatcctgctg agcgacatcc 960 tgagagtcaa cacagaaatc acaaaggcac cgctgagcgc aagcatgatc aagagatacg 1020 acgaacacca ccaggacctg acactgctga aggcactggt cagacagcag ctgccggaaa 1080 agtacaagga aatcttcttc gaccagagca agaacggata cgcaggatac atcgacggag 1140 gagcaagcca ggaagaattc tacaagttca tcaagccgat cctggaaaag atggacggaa 1200 cagaagaact gctggtcaag ctgaacagag aagacctgct gagaaagcag agaacattcg 1260 acaacggaag catcccgcac cagatccacc tgggagaact gcacgcaatc ctgagaagac 1320 aggaagactt ctacccgttc ctgaaggaca acagagaaaa gatcgaaaag atcctgacat 1380 tcagaatccc gtactacgtc ggaccgctgg caagaggaaa cagcagattc gcatggatga 1440 caagaaagag cgaagaaaca atcacaccgt ggaacttcga agaagtcgtc gacaagggag 1500 caagcgcaca gagcttcatc gaaagaatga caaacttcga caagaacctg ccgaacgaaa 1560 aggtcctgcc gaagcacagc ctgctgtacg aatacttcac agtctacaac gaactgacaa 1620 aggtcaagta cgtcacagaa ggaatgagaa agccggcatt cctgagcgga gaacagaaga 1680 aggcaatcgt cgacctgctg ttcaagacaa acagaaaggt cacagtcaag cagctgaagg 1740 aagactactt caagaagatc gaatgcttcg acagcgtcga aatcagcgga gtcgaagaca 1800 gattcaacgc aagcctggga acataccacg acctgctgaa gatcatcaag gacaaggact 1860 tcctggacaa cgaagaaaac gaagacatcc tggaagacat cgtcctgaca ctgacactgt 1920 tcgaagacag agaaatgatc gaagaaagac tgaagacata cgcacacctg ttcgacgaca 1980 aggtcatgaa gcagctgaag agaagaagat acacaggatg gggaagactg agcagaaagc 2040 tgatcaacgg aatcagagac aagcagagcg gaaagacaat cctggacttc ctgaagagcg 2100 acggattcgc aaacagaaac ttcatgcagc tgatccacga cgacagcctg acattcaagg 2160 aagacatcca gaaggcacag gtcagcggac agggagacag cctgcacgaa cacatcgcaa 2220 acctggcagg aagcccggca atcaagaagg gaatcctgca gacagtcaag gtcgtcgacg 2280 aactggtcaa ggtcatggga agacacaagc cggaaaacat cgtcatcgaa atggcaagag 2340 aaaaccagac aacacagaag ggacagaaga acagcagaga aagaatgaag agaatcgaag 2400 aaggaatcaa ggaactggga agccagatcc tgaaggaaca cccggtcgaa aacacacagc 2460 tgcagaacga aaagctgtac ctgtactacc tgcagaacgg aagagacatg tacgtcgacc 2520 aggaactgga catcaacaga ctgagcgact acgacgtcga ccacatcgtc ccgcagagct 2580 tcctgaagga cgacagcatc gacaacaagg tcctgacaag aagcgacaag aacagaggaa 2640 agagcgacaa cgtcccgagc gaagaagtcg tcaagaagat gaagaactac tggagacagc 2700 tgctgaacgc aaagctgatc acacagagaa agttcgacaa cctgacaaag gcagagagag 2760 gaggactgag cgaactggac aaggcaggat tcatcaagag acagctggtc gaaacaagac 2820 agatcacaaa gcacgtcgca cagatcctgg acagcagaat gaacacaaag tacgacgaaa 2880 acgacaagct gatcagagaa gtcaaggtca tcacactgaa gagcaagctg gtcagcgact 2940 tcagaaagga cttccagttc tacaaggtca gagaaatcaa caactaccac cacgcacacg 3000 acgcatacct gaacgcagtc gtcggaacag cactgatcaa gaagtacccg aagctggaaa 3060 gcgaattcgt ctacggagac tacaaggtct acgacgtcag aaagatgatc gcaaagagcg 3120 aacaggaaat cggaaaggca acagcaaagt acttcttcta cagcaacatc atgaacttct 3180 tcaagacaga aatcacactg gcaaacggag aaatcagaaa gagaccgctg atcgaaacaa 3240 acggagaaac aggagaaatc gtctgggaca agggaagaga cttcgcaaca gtcagaaagg 3300 tcctgagcat gccgcaggtc aacatcgtca agaagacaga agtccagaca ggaggattca 3360 gcaaggaaag catcctgccg aagagaaaca gcgacaagct gatcgcaaga aagaaggact 3420 gggacccgaa gaagtacgga ggattcgaca gcccgacagt cgcatacagc gtcctggtcg 3480 tcgcaaaggt cgaaaaggga aagagcaaga agctgaagag cgtcaaggaa ctgctgggaa 3540 tcacaatcat ggaaagaagc agcttcgaaa agaacccgat cgacttcctg gaagcaaagg 3600 gatacaagga agtcaagaag gacctgatca tcaagctgcc gaagtacagc ctgttcgaac 3660 tggaaaacgg aagaaagaga atgctggcaa gcgcaggaga actgcagaag ggaaacgaac 3720 tggcactgcc gagcaagtac gtcaacttcc tgtacctggc aagccactac gaaaagctga 3780 agggaagccc ggaagacaac gaacagaagc agctgttcgt cgaacagcac aagcactacc 3840 tggacgaaat catcgaacag atcagcgaat tcagcaagag agtcatcctg gcagacgcaa 3900 acctggacaa ggtcctgagc gcatacaaca agcacagaga caagccgatc agagaacagg 3960 cagaaaacat catccacctg ttcacactga caaacctggg agcaccggca gcattcaagt 4020 acttcgacac aacaatcgac agaaagagat acacaagcac aaaggaagtc ctggacgcaa 4080 cactgatcca ccagagcatc acaggactgt acgaaacaag aatcgacctg agccagctgg 4140 gaggagacgg aggaggaagc ccgaagaaga agagaaaggt ctagctagca ccagcctcaa 4200 gaacacccga atggagtctc taagctacat aataccaact tacactttac aaaatgttgt 4260 cccccaaaat gtagccattc gtatctgctc ctaataaaaa gaaagtttct tcacattctc 4320 tcgag 4325 <210> 61 <211> 4411 <212> ADN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 61 aggtcccgca gtcggcgtcc agcggctctg cttgttcgtg tgtgtgtcgt tgcaggcctt 60 attcggatcc gccaccatgg acaagaagta cagcatcgga ctggacatcg gaacaaacag 120 cgtcggatgg gcagtcatca cagacgaata caaggtcccg agcaagaagt tcaaggtcct 180 gggaaacaca gacagacaca gcatcaagaa gaacctgatc ggagcactgc tgttcgacag 240 cggagaaaca gcagaagcaa caagactgaa gagaacagca agaagaagat acacaagaag 300 aaagaacaga atctgctacc tgcaggaaat cttcagcaac gaaatggcaa aggtcgacga 360 cagcttcttc cacagactgg aagaaagctt cctggtcgaa gaagacaaga agcacgaaag 420 acacccgatc ttcggaaaca tcgtcgacga agtcgcatac cacgaaaagt acccgacaat 480 ctaccacctg agaaagaagc tggtcgacag cacagacaag gcagacctga gactgatcta 540 cctggcactg gcacacatga tcaagttcag aggacacttc ctgatcgaag gagacctgaa 600 cccggacaac agcgacgtcg acaagctgtt catccagctg gtccagacat acaaccagct 660 gttcgaagaa aacccgatca acgcaagcgg agtcgacgca aaggcaatcc tgagcgcaag 720 actgagcaag agcagaagac tggaaaacct gatcgcacag ctgccgggag aaaagaagaa 780 cggactgttc ggaaacctga tcgcactgag cctgggactg acaccgaact tcaagagcaa 840 cttcgacctg gcagaagacg caaagctgca gctgagcaag gacacatacg acgacgacct 900 ggacaacctg ctggcacaga tcggagacca gtacgcagac ctgttcctgg cagcaaagaa 960 cctgagcgac gcaatcctgc tgagcgacat cctgagagtc aacacagaaa tcacaaaggc 1020 accgctgagc gcaagcatga tcaagagata cgacgaacac caccaggacc tgacactgct 1080 gaaggcactg gtcagacagc agctgccgga aaagtacaag gaaatcttct tcgaccagag 1140 caagaacgga tacgcaggat acatcgacgg aggagcaagc caggaagaat tctacaagtt 1200 catcaagccg atcctggaaa agatggacgg aacagaagaa ctgctggtca agctgaacag 1260 agaagacctg ctgagaaagc agagaacatt cgacaacgga agcatcccgc accagatcca 1320 cctgggagaa ctgcacgcaa tcctgagaag acaggaagac ttctacccgt tcctgaagga 1380 caacagagaa aagatcgaaa agatcctgac attcagaatc ccgtactacg tcggaccgct 1440 ggcaagagga aacagcagat tcgcatggat gacaagaaag agcgaagaaa caatcacacc 1500 gtggaacttc gaagaagtcg tcgacaaggg agcaagcgca cagagcttca tcgaaagaat 1560 gacaaacttc gacaagaacc tgccgaacga aaaggtcctg ccgaagcaca gcctgctgta 1620 cgaatacttc acagtctaca acgaactgac aaaggtcaag tacgtcacag aaggaatgag 1680 aaagccggca ttcctgagcg gagaacagaa gaaggcaatc gtcgacctgc tgttcaagac 1740 aaacagaaag gtcacagtca agcagctgaa ggaagactac ttcaagaaga tcgaatgctt 1800 cgacagcgtc gaaatcagcg gagtcgaaga cagattcaac gcaagcctgg gaacatacca 1860 cgacctgctg aagatcatca aggacaagga cttcctggac aacgaagaaa acgaagacat 1920 cctggaagac atcgtcctga cactgacact gttcgaagac agagaaatga tcgaagaaag 1980 actgaagaca tacgcacacc tgttcgacga caaggtcatg aagcagctga agagaagaag 2040 atacacagga tggggaagac tgagcagaaa gctgatcaac ggaatcagag acaagcagag 2100 cggaaagaca atcctggact tcctgaagag cgacggattc gcaaacagaa acttcatgca 2160 gctgatccac gacgacagcc tgacattcaa ggaagacatc cagaaggcac aggtcagcgg 2220 acagggagac agcctgcacg aacacatcgc aaacctggca ggaagcccgg caatcaagaa 2280 gggaatcctg cagacagtca aggtcgtcga cgaactggtc aaggtcatgg gaagacacaa 2340 gccggaaaac atcgtcatcg aaatggcaag agaaaaccag acaacacaga agggacagaa 2400 gaacagcaga gaaagaatga agagaatcga agaaggaatc aaggaactgg gaagccagat 2460 cctgaaggaa cacccggtcg aaaacacaca gctgcagaac gaaaagctgt acctgtacta 2520 cctgcagaac ggaagagaca tgtacgtcga ccaggaactg gacatcaaca gactgagcga 2580 ctacgacgtc gaccacatcg tcccgcagag cttcctgaag gacgacagca tcgacaacaa 2640 ggtcctgaca agaagcgaca agaacagagg aaagagcgac aacgtcccga gcgaagaagt 2700 cgtcaagaag atgaagaact actggagaca gctgctgaac gcaaagctga tcacacagag 2760 aaagttcgac aacctgacaa aggcagagag aggaggactg agcgaactgg acaaggcagg 2820 attcatcaag agacagctgg tcgaaacaag acagatcaca aagcacgtcg cacagatcct 2880 ggacagcaga atgaacacaa agtacgacga aaacgacaag ctgatcagag aagtcaaggt 2940 catcacactg aagagcaagc tggtcagcga cttcagaaag gacttccagt tctacaaggt 3000 cagagaaatc aacaactacc accacgcaca cgacgcatac ctgaacgcag tcgtcggaac 3060 agcactgatc aagaagtacc cgaagctgga aagcgaattc gtctacggag actacaaggt 3120 ctacgacgtc agaaagatga tcgcaaagag cgaacaggaa atcggaaagg caacagcaaa 3180 gtacttcttc tacagcaaca tcatgaactt cttcaagaca gaaatcacac tggcaaacgg 3240 agaaatcaga aagagaccgc tgatcgaaac aaacggagaa acaggagaaa tcgtctggga 3300 caagggaaga gacttcgcaa cagtcagaaa ggtcctgagc atgccgcagg tcaacatcgt 3360 caagaagaca gaagtccaga caggaggatt cagcaaggaa agcatcctgc cgaagagaaa 3420 cagcgacaag ctgatcgcaa gaaagaagga ctgggacccg aagaagtacg gaggattcga 3480 cagcccgaca gtcgcataca gcgtcctggt cgtcgcaaag gtcgaaaagg gaaagagcaa 3540 gaagctgaag agcgtcaagg aactgctggg aatcacaatc atggaaagaa gcagcttcga 3600 aaagaacccg atcgacttcc tggaagcaaa gggatacaag gaagtcaaga aggacctgat 3660 catcaagctg ccgaagtaca gcctgttcga actggaaaac ggaagaaaga gaatgctggc 3720 aagcgcagga gaactgcaga agggaaacga actggcactg ccgagcaagt acgtcaactt 3780 cctgtacctg gcaagccact acgaaaagct gaagggaagc ccggaagaca acgaacagaa 3840 gcagctgttc gtcgaacagc acaagcacta cctggacgaa atcatcgaac agatcagcga 3900 attcagcaag agagtcatcc tggcagacgc aaacctggac aaggtcctga gcgcatacaa 3960 caagcacaga gacaagccga tcagagaaca ggcagaaaac atcatccacc tgttcacact 4020 gacaaacctg ggagcaccgg cagcattcaa gtacttcgac acaacaatcg acagaaagag 4080 atacacaagc acaaaggaag tcctggacgc aacactgatc caccagagca tcacaggact 4140 gtacgaaaca agaatcgacc tgagccagct gggaggagac ggaggaggaa gcccgaagaa 4200 gaagagaaag gtctagctag ccatcacatt taaaagcatc tcagcctacc atgagaataa 4260 gagaaagaaa atgaagatca atagcttatt catctctttt tctttttcgt tggtgtaaag 4320 ccaacaccct gtctaaaaaa cataaatttc tttaatcatt ttgcctcttt tctctgtgct 4380 tcaattaata aaaaatggaa agaacctcga g 4411 <210> 62 <211> 105 <212> ADN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 62 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa gcgaaaaaaa aaaaaaaaaa aaaaaaaaaa 60 aaaccgaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa 105 <210> 63 <211> 93 <212> ADN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Oligonucleótido sintético" <400> 63 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 60 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa 93 <210> 64 <211> 100 <212> ARN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <220> <221> modified_base <222> (1)..(3) <223> Modificada 2’-O-metilo <220> <221> misc_feature <222> (1)..(4) <223> Enlace fosforotiotato <220> <221> modified_base <222> (97)..(99) <223> Modificada 2’-O-metilo <220> <221> misc_feature <222> (97)..(100) <223> Enlace fosforotiotato <400> 64 ccaguccagc gaggcaaagg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc 60 cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu 100 <210> 65 <211> 3312 <212> ADN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 65 atggcagcat tcaagccgaa ctcgatcaac tacatcctgg gactggacat cggaatcgca 60 tcggtcggat gggcaatggt cgaaatcgac gaagaagaaa acccgatcag actgatcgac 120 ctgggagtca gagtcttcga aagagcagaa gtcccgaaga caggagactc gctggcaatg 180 gcaagaagac tggcaagatc ggtcagaaga ctgacaagaa gaagagcaca cagactgctg 240 agaacaagaa gactgctgaa gagagaagga gtcctgcagg cagcaaactt cgacgaaaac 300 ggactgatca agtcgctgcc gaacacaccg tggcagctga gagcagcagc actggacaga 360 aagctgacac cgctggaatg gtcggcagtc ctgctgcacc tgatcaagca cagaggatac 420 ctgtcgcaga gaaagaacga aggagaaaca gcagacaagg aactgggagc actgctgaag 480 ggagtcgcag gaaacgcaca cgcactgcag acaggagact tcagaacacc ggcagaactg 540 gcactgaaca agttcgaaaa ggaatcggga cacatcagaa accagagatc ggactactcg 600 cacacattct cgagaaagga cctgcaggca gaactgatcc tgctgttcga aaagcagaag 660 gaattcggaa acccgcacgt ctcgggagga ctgaaggaag gaatcgaaac actgctgatg 720 acacagagac cggcactgtc gggagacgca gtccagaaga tgctgggaca ctgcacattc 780 gaaccggcag aaccgaaggc agcaaagaac acatacacag cagaaagatt catctggctg 840 acaaagctga acaacctgag aatcctggaa cagggatcgg aaagaccgct gacagacaca 900 gaaagagcaa cactgatgga cgaaccgtac agaaagtcga agctgacata cgcacaggca 960 agaaagctgc tgggactgga agacacagca ttcttcaagg gactgagata cggaaaggac 1020 aacgcagaag catcgacact gatggaaatg aaggcatacc acgcaatctc gagagcactg 1080 gaaaaggaag gactgaagga caagaagtcg ccgctgaacc tgtcgccgga actgcaggac 1140 gaaatcggaa cagcattctc gctgttcaag acagacgaag acatcacagg aagactgaag 1200 gacagaatcc agccggaaat cctggaagca ctgctgaagc acatctcgtt cgacaagttc 1260 gtccagatct cgctgaaggc actgagaaga atcgtcccgc tgatggaaca gggaaagaga 1320 tacgacgaag catgcgcaga aatctacgga gaccactacg gaaagaagaa cacagaagaa 1380 aagatctacc tgccgccgat cccggcagac gaaatcagaa acccggtcgt cctgagagca 1440 ctgtcgcagg caagaaaggt catcaacgga gtcgtcagaa gatacggatc gccggcaaga 1500 atccacatcg aaacagcaag agaagtcgga aagtcgttca aggacagaaa ggaaatcgaa 1560 aagagacagg aagaaaacag aaaggacaga gaaaaggcag cagcaaagtt cagagaatac 1620 ttcccgaact tcgtcggaga accgaagtcg aaggacatcc tgaagctgag actgtacgaa 1680 cagcagcacg gaaagtgcct gtactcggga aaggaaatca acctgggaag actgaacgaa 1740 aagggatacg tcgaaatcga ccacgcactg ccgttctcga gaacatggga cgactcgttc 1800 aacaacaagg tcctggtcct gggatcggaa aaccagaaca agggaaacca gacaccgtac 1860 gaatacttca acggaaagga caactcgaga gaatggcagg aattcaaggc aagagtcgaa 1920 acatcgagat tcccgagatc gaagaagcag agaatcctgc tgcagaagtt cgacgaagac 1980 ggattcaagg aaagaaacct gaacgacaca agatacgtca acagattcct gtgccagttc 2040 gtcgcagaca gaatgagact gacaggaaag ggaaagaaga gagtcttcgc atcgaacgga 2100 cagatcacaa acctgctgag aggattctgg ggactgagaa aggtcagagc agaaaacgac 2160 agacaccacg cactggacgc agtcgtcgtc gcatgctcga cagtcgcaat gcagcagaag 2220 atcacaagat tcgtcagata caaggaaatg aacgcattcg acggaaagac aatcgacaag 2280 gaaacaggag aagtcctgca ccagaagaca cacttcccgc agccgtggga attcttcgca 2340 caggaagtca tgatcagagt cttcggaaag ccggacggaa agccggaatt cgaagaagca 2400 gacacactgg aaaagctgag aacactgctg gcagaaaagc tgtcgtcgag accggaagca 2460 gtccacgaat acgtcacacc gctgttcgtc tcgagagcac cgaacagaaa gatgtcggga 2520 cagggacaca tggaaacagt caagtcggca aagagactgg acgaaggagt ctcggtcctg 2580 agagtcccgc tgacacagct gaagctgaag gacctggaaa agatggtcaa cagagaaaga 2640 gaaccgaagc tgtacgaagc actgaaggca agactggaag cacacaagga cgacccggca 2700 aaggcattcg cagaaccgtt ctacaagtac gacaaggcag gaaacagaac acagcaggtc 2760 aaggcagtca gagtcgaaca ggtccagaag acaggagtct gggtcagaaa ccacaacgga 2820 atcgcagaca acgcaacaat ggtcagagta gacgtcttcg aaaagggaga caagtactac 2880 ctggtcccga tctactcgtg gcaggtcgca aagggaatcc tgccggacag agcagtcgtc 2940 cagggaaagg acgaagaaga ctggcagctg atcgacgact cgttcaactt caagttctcg 3000 ctgcacccga acgacctggt cgaagtcatc acaaagaagg caagaatgtt cggatacttc 3060 gcatcgtgcc acagaggaac aggaaacatc aacatcagaa tccacgacct ggaccacaag 3120 atcggaaaga acggaatcct ggaaggaatc ggagtcaaga cagcactgtc gttccagaag 3180 taccagatcg acgaactggg aaaggaaatc agaccgtgca gactgaagaa gagaccgccg 3240 gtcagatccg gaaagagaac agcagacgga tcggaattcg aatcgccgaa gaagaagaga 3300 aaggtcgaat ga 3312 <210> 66 <211> 3306 <212> ADN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 66 gcagcattca agccgaactc gatcaactac atcctgggac tggacatcgg aatcgcatcg 60 gtcggatggg caatggtcga aatcgacgaa gaagaaaacc cgatcagact gatcgacctg 120 ggagtcagag tcttcgaaag agcagaagtc ccgaagacag gagactcgct ggcaatggca 180 agaagactgg caagatcggt cagaagactg acaagaagaa gagcacacag actgctgaga 240 acaagaagac tgctgaagag agaaggagtc ctgcaggcag caaacttcga cgaaaacgga 300 ctgatcaagt cgctgccgaa cacaccgtgg cagctgagag cagcagcact ggacagaaag 360 ctgacaccgc tggaatggtc ggcagtcctg ctgcacctga tcaagcacag aggatacctg 420 tcgcagagaa agaacgaagg agaaacagca gacaaggaac tgggagcact gctgaaggga 480 gtcgcaggaa acgcacacgc actgcagaca ggagacttca gaacaccggc agaactggca 540 ctgaacaagt tcgaaaagga atcgggacac atcagaaacc agagatcgga ctactcgcac 600 acattctcga gaaaggacct gcaggcagaa ctgatcctgc tgttcgaaaa gcagaaggaa 660 ttcggaaacc cgcacgtctc gggaggactg aaggaaggaa tcgaaacact gctgatgaca 720 cagagaccgg cactgtcggg agacgcagtc cagaagatgc tgggacactg cacattcgaa 780 ccggcagaac cgaaggcagc aaagaacaca tacacagcag aaagattcat ctggctgaca 840 aagctgaaca acctgagaat cctggaacag ggatcggaaa gaccgctgac agacacagaa 900 agagcaacac tgatggacga accgtacaga aagtcgaagc tgacatacgc acaggcaaga 960 aagctgctgg gactggaaga cacagcattc ttcaagggac tgagatacgg aaaggacaac 1020 gcagaagcat cgacactgat ggaaatgaag gcataccacg caatctcgag agcactggaa 1080 aaggaaggac tgaaggacaa gaagtcgccg ctgaacctgt cgccggaact gcaggacgaa 1140 atcggaacag cattctcgct gttcaagaca gacgaagaca tcacaggaag actgaaggac 1200 agaatccagc cggaaatcct ggaagcactg ctgaagcaca tctcgttcga caagttcgtc 1260 cagatctcgc tgaaggcact gagaagaatc gtcccgctga tggaacaggg aaagagatac 1320 gacgaagcat gcgcagaaat ctacggagac cactacggaa agaagaacac agaagaaaag 1380 atctacctgc cgccgatccc ggcagacgaa atcagaaacc cggtcgtcct gagagcactg 1440 tcgcaggcaa gaaaggtcat caacggagtc gtcagaagat acggatcgcc ggcaagaatc 1500 cacatcgaaa cagcaagaga agtcggaaag tcgttcaagg acagaaagga aatcgaaaag 1560 agacaggaag aaaacagaaa ggacagagaa aaggcagcag caaagttcag agaatacttc 1620 ccgaacttcg tcggagaacc gaagtcgaag gacatcctga agctgagact gtacgaacag 1680 cagcacggaa agtgcctgta ctcgggaaag gaaatcaacc tgggaagact gaacgaaaag 1740 ggatacgtcg aaatcgacca cgcactgccg ttctcgagaa catgggacga ctcgttcaac 1800 aacaaggtcc tggtcctggg atcggaaaac cagaacaagg gaaaccagac accgtacgaa 1860 tacttcaacg gaaaggacaa ctcgagagaa tggcaggaat tcaaggcaag agtcgaaaca 1920 tcgagattcc cgagatcgaa gaagcagaga atcctgctgc agaagttcga cgaagacgga 1980 ttcaaggaaa gaaacctgaa cgacacaaga tacgtcaaca gattcctgtg ccagttcgtc 2040 gcagacagaa tgagactgac aggaaaggga aagaagagag tcttcgcatc gaacggacag 2100 atcacaaacc tgctgagagg attctgggga ctgagaaagg tcagagcaga aaacgacaga 2160 caccacgcac tggacgcagt cgtcgtcgca tgctcgacag tcgcaatgca gcagaagatc 2220 acaagattcg tcagatacaa ggaaatgaac gcattcgacg gaaagacaat cgacaaggaa 2280 acaggagaag tcctgcacca gaagacacac ttcccgcagc cgtgggaatt cttcgcacag 2340 gaagtcatga tcagagtctt cggaaagccg gacggaaagc cggaattcga agaagcagac 2400 acactggaaa agctgagaac actgctggca gaaaagctgt cgtcgagacc ggaagcagtc 2460 cacgaatacg tcacaccgct gttcgtctcg agagcaccga acagaaagat gtcgggacag 2520 ggacacatgg aaacagtcaa gtcggcaaag agactggacg aaggagtctc ggtcctgaga 2580 gtcccgctga cacagctgaa gctgaaggac ctggaaaaga tggtcaacag agaaagagaa 2640 ccgaagctgt acgaagcact gaaggcaaga ctggaagcac acaaggacga cccggcaaag 2700 gcattcgcag aaccgttcta caagtacgac aaggcaggaa acagaacaca gcaggtcaag 2760 gcagtcagag tcgaacaggt ccagaagaca ggagtctggg tcagaaacca caacggaatc 2820 gcagacaacg caacaatggt cagagtagac gtcttcgaaa agggagacaa gtactacctg 2880 gtcccgatct actcgtggca ggtcgcaaag ggaatcctgc cggacagagc agtcgtccag 2940 ggaaaggacg aagaagactg gcagctgatc gacgactcgt tcaacttcaa gttctcgctg 3000 cacccgaacg acctggtcga agtcatcaca aagaaggcaa gaatgttcgg atacttcgca 3060 tcgtgccaca gaggaacagg aaacatcaac atcagaatcc acgacctgga ccacaagatc 3120 ggaaagaacg gaatcctgga aggaatcgga gtcaagacag cactgtcgtt ccagaagtac 3180 cagatcgacg aactgggaaa ggaaatcaga ccgtgcagac tgaagaagag accgccggtc 3240 agatccggaa agagaacagc agacggatcg gaattcgaat cgccgaagaa gaagagaaag 3300 gtcgaa 3306 <210> 67 <211> 3636 <212> ADN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 67 gggagaccca agctggctag cgtttaaact taagcttgga tccgccacca tggcagcatt 60 caagccgaac tcgatcaact acatcctggg actggacatc ggaatcgcat cggtcggatg 120 ggcaatggtc gaaatcgacg aagaagaaaa cccgatcaga ctgatcgacc tgggagtcag 180 agtcttcgaa agagcagaag tcccgaagac aggagactcg ctggcaatgg caagaagact 240 ggcaagatcg gtcagaagac tgacaagaag aagagcacac agactgctga gaacaagaag 300 actgctgaag agagaaggag tcctgcaggc agcaaacttc gacgaaaacg gactgatcaa 360 gtcgctgccg aacacaccgt ggcagctgag agcagcagca ctggacagaa agctgacacc 420 gctggaatgg tcggcagtcc tgctgcacct gatcaagcac agaggatacc tgtcgcagag 480 aaagaacgaa ggagaaacag cagacaagga actgggagca ctgctgaagg gagtcgcagg 540 aaacgcacac gcactgcaga caggagactt cagaacaccg gcagaactgg cactgaacaa 600 gttcgaaaag gaatcgggac acatcagaaa ccagagatcg gactactcgc acacattctc 660 gagaaaggac ctgcaggcag aactgatcct gctgttcgaa aagcagaagg aattcggaaa 720 cccgcacgtc tcgggaggac tgaaggaagg aatcgaaaca ctgctgatga cacagagacc 780 ggcactgtcg ggagacgcag tccagaagat gctgggacac tgcacattcg aaccggcaga 840 accgaaggca gcaaagaaca catacacagc agaaagattc atctggctga caaagctgaa 900 caacctgaga atcctggaac agggatcgga aagaccgctg acagacacag aaagagcaac 960 actgatggac gaaccgtaca gaaagtcgaa gctgacatac gcacaggcaa gaaagctgct 1020 gggactggaa gacacagcat tcttcaaggg actgagatac ggaaaggaca acgcagaagc 1080 atcgacactg atggaaatga aggcatacca cgcaatctcg agagcactgg aaaaggaagg 1140 actgaaggac aagaagtcgc cgctgaacct gtcgccggaa ctgcaggacg aaatcggaac 1200 agcattctcg ctgttcaaga cagacgaaga catcacagga agactgaagg acagaatcca 1260 gccggaaatc ctggaagcac tgctgaagca catctcgttc gacaagttcg tccagatctc 1320 gctgaaggca ctgagaagaa tcgtcccgct gatggaacag ggaaagagat acgacgaagc 1380 atgcgcagaa atctacggag accactacgg aaagaagaac acagaagaaa agatctacct 1440 gccgccgatc ccggcagacg aaatcagaaa cccggtcgtc ctgagagcac tgtcgcaggc 1500 aagaaaggtc atcaacggag tcgtcagaag atacggatcg ccggcaagaa tccacatcga 1560 aacagcaaga gaagtcggaa agtcgttcaa ggacagaaag gaaatcgaaa agagacagga 1620 agaaaacaga aaggacagag aaaaggcagc agcaaagttc agagaatact tcccgaactt 1680 cgtcggagaa ccgaagtcga aggacatcct gaagctgaga ctgtacgaac agcagcacgg 1740 aaagtgcctg tactcgggaa aggaaatcaa cctgggaaga ctgaacgaaa agggatacgt 1800 cgaaatcgac cacgcactgc cgttctcgag aacatgggac gactcgttca acaacaaggt 1860 cctggtcctg ggatcggaaa accagaacaa gggaaaccag acaccgtacg aatacttcaa 1920 cggaaaggac aactcgagag aatggcagga attcaaggca agagtcgaaa catcgagatt 1980 cccgagatcg aagaagcaga gaatcctgct gcagaagttc gacgaagacg gattcaagga 2040 aagaaacctg aacgacacaa gatacgtcaa cagattcctg tgccagttcg tcgcagacag 2100 aatgagactg acaggaaagg gaaagaagag agtcttcgca tcgaacggac agatcacaaa 2160 cctgctgaga ggattctggg gactgagaaa ggtcagagca gaaaacgaca gacaccacgc 2220 actggacgca gtcgtcgtcg catgctcgac agtcgcaatg cagcagaaga tcacaagatt 2280 cgtcagatac aaggaaatga acgcattcga cggaaagaca atcgacaagg aaacaggaga 2340 agtcctgcac cagaagacac acttcccgca gccgtgggaa ttcttcgcac aggaagtcat 2400 gatcagagtc ttcggaaagc cggacggaaa gccggaattc gaagaagcag acacactgga 2460 aaagctgaga acactgctgg cagaaaagct gtcgtcgaga ccggaagcag tccacgaata 2520 cgtcacaccg ctgttcgtct cgagagcacc gaacagaaag atgtcgggac agggacacat 2580 ggaaacagtc aagtcggcaa agagactgga cgaaggagtc tcggtcctga gagtcccgct 2640 gacacagctg aagctgaagg acctggaaaa gatggtcaac agagaaagag aaccgaagct 2700 gtacgaagca ctgaaggcaa gactggaagc acacaaggac gacccggcaa aggcattcgc 2760 agaaccgttc tacaagtacg acaaggcagg aaacagaaca cagcaggtca aggcagtcag 2820 agtcgaacag gtccagaaga caggagtctg ggtcagaaac cacaacggaa tcgcagacaa 2880 cgcaacaatg gtcagagtag acgtcttcga aaagggagac aagtactacc tggtcccgat 2940 ctactcgtgg caggtcgcaa agggaatcct gccggacaga gcagtcgtcc agggaaagga 3000 cgaagaagac tggcagctga tcgacgactc gttcaacttc aagttctcgc tgcacccgaa 3060 cgacctggtc gaagtcatca caaagaaggc aagaatgttc ggatacttcg catcgtgcca 3120 cagaggaaca ggaaacatca acatcagaat ccacgacctg gaccacaaga tcggaaagaa 3180 cggaatcctg gaaggaatcg gagtcaagac agcactgtcg ttccagaagt accagatcga 3240 cgaactggga aaggaaatca gaccgtgcag actgaagaag agaccgccgg tcagatccgg 3300 aaagagaaca gcagacggat cggaattcga atcgccgaag aagaagagaa aggtcgaatg 3360 atagctagct cgagtctaga gggcccgttt aaacccgctg atcagcctcg actgtgcctt 3420 ctagttgcca gccatctgtt gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg 3480 ccactcccac tgtcctttcc taataaaatg aggaaattgc atcgcattgt ctgagtaggt 3540 gtcattctat tctggggggt ggggtggggc aggacagcaa gggggaggat tgggaagaca 3600 atagcaggca tgctggggat gcggtgggct ctatgg 3636 <210> 68 <211> 1103 <212> PRT <213> Neisseria meningitidis <400> 68 Met Ala Ala Phe Lys Pro Asn Ser Ile Asn Tyr Ile Leu Gly Leu Asp 1 5 10 15 Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Glu 20 25 30 Glu Asn Pro Ile Arg Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 35 40 45 Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 50 55 60 Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 65 70 75 80 Arg Thr Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asn 85 90 95 Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 100 105 110 Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 115 120 125 Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 130 135 140 Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 145 150 155 160 Gly Val Ala Gly Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 165 170 175 Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 180 185 190 Arg Asn Gln Arg Ser Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 195 200 205 Gln Ala Glu Leu Ile Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 210 215 220 Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 225 230 235 240 Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 245 250 255 His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 260 265 270 Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 275 280 285 Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 290 295 300 Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 305 310 315 320 Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 325 330 335 Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 340 345 350 Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 355 360 365 Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 370 375 380 Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 385 390 395 400 Asp Arg Ile Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 405 410 415 Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 420 425 430 Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 435 440 445 Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 450 455 460 Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 465 470 475 480 Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 485 490 495 Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 500 505 510 Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 515 520 525 Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 530 535 540 Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 545 550 555 560 Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 565 570 575 Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 580 585 590 Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 595 600 605 Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 610 615 620 Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 625 630 635 640 Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 645 650 655 Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 660 665 670 Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp Arg Met Arg Leu Thr 675 680 685 Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 690 695 700 Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 705 710 715 720 Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 725 730 735 Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 740 745 750 Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 755 760 765 Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 770 775 780 Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 785 790 795 800 Asp Thr Leu Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 805 810 815 Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 820 825 830 Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 835 840 845 Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 850 855 860 Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 865 870 875 880 Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 885 890 895 Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 900 905 910 Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 915 920 925 Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 930 935 940 Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Asp Lys Tyr Tyr 945 950 955 960 Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 965 970 975 Arg Ala Val Val Gln Gly Lys Asp Glu Glu Asp Trp Gln Leu Ile Asp 980 985 990 Asp Ser Phe Asn Phe Lys Phe Ser Leu His Pro Asn Asp Leu Val Glu 995 1000 1005 Val Ile Thr Lys Lys Ala Arg Met Phe Gly Tyr Phe Ala Ser Cys 1010 1015 1020 His Arg Gly Thr Gly Asn Ile Asn Ile Arg Ile His Asp Leu Asp 1025 1030 1035 His Lys Ile Gly Lys Asn Gly Ile Leu Glu Gly Ile Gly Val Lys 1040 1045 1050 Thr Ala Leu Ser Phe Gln Lys Tyr Gln Ile Asp Glu Leu Gly Lys 1055 1060 1065 Glu Ile Arg Pro Cys Arg Leu Lys Lys Arg Pro Pro Val Arg Ser 1070 1075 1080 Gly Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys 1085 1090 1095 Lys Arg Lys Val Glu 1100 <210> 69 <211> 100 <212> ARN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <220> <221> modified_base <222> (1)..(3) <223> Modificada 2’-O-metilo <220> <221> misc_feature <222> (1)..(4) <223> Enlace fosforotiotato <220> <221> modified_base <222> (29)..(40) <223> Modificada 2’-O-metilo <220> <221> modified_base <222> (69)..(100) <223> Modificada 2’-O-metilo <220> <221> misc_feature <222> (97)..(100) <223> Enlace fosforotiotato <400> 69 gccgagucug gagagcugca guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc 60 cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu 100 <210> 70 <211> 100 <212> ARN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <220> <221> modified_base <222> (1)..(3) <223> Modificada 2’-O-metilo <220> <221> misc_feature <222> (1)..(4) <223> Enlace fosforotiotato <220> <221> modified_base <222> (29)..(40) <223> Modificada 2’-O-metilo <220> <221> modified_base <222> (69)..(100) <223> Modificada 2’-O-metilo <220> <221> misc_feature <222> (97)..(100) <223> Enlace fosforotiotato <400> 70 acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc 60 cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu 100 <210> 71 <211> 100 <212> ARN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <220> <221> modified_base <222> (1)..(3) <223> Modificada 2’-O-metilo <220> <221> misc_feature <222> (1)..(4) <223> Enlace fosforotiotato <220> <221> modified_base <222> (29)..(40) <223> Modificada 2’-O-metilo <220> <221> modified_base <222> (69)..(100) <223> Modificada 2’-O-metilo <220> <221> misc_feature <222> (97)..(100) <223> Enlace fosforotiotato <400> 71 aaaguucuag augccguccg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc 60 cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu 100 <210> 72 <211> 100 <212> ARN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <220> <221> modified_base <222> (1)..(3) <223> Modificada 2’-O-metilo <220> <221> misc_feature <222> (1)..(4) <223> Enlace fosforotiotato <220> <221> modified_base <222> (29)..(40) <223> Modificada 2’-O-metilo <220> <221> modified_base <222> (69)..(100) <223> Modificada 2’-O-metilo <220> <221> misc_feature <222> (97)..(100) <223> Enlace fosforotiotato <400> 72 acgcaaauau caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc 60 cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu 100 <210> 73 <211> 7 <212> PRT <213> Virus de simio 40 <400> 73 Pro Lys Lys Lys Arg Lys Val 1 5 <210> 74 <211> 7 <212> PRT <213> Virus de simio 40 <400> 74 Pro Lys Lys Lys Arg Arg Val 1 5 <210> 75 <211> 16 <212> PRT <213> Desconocido <220> <221> fuente <223> /nota="Descripción de desconocido: Secuencia NLS bipartita de nucleoplasmina" <400> 75 Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 1 5 10 15 <210> 76 <211> 6 <212> PRT <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Etiqueta 6xHis sintética" <400> 76 His His His His His His 1 5 <210> 77 <211> 8 <212> PRT <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Etiqueta 8xHis sintética" <400> 77 His His His His His His His His 1 5 <210> 78 <211> 10 <212> ARN <213> Desconocido <220> <221> fuente <223> /nota="Descripción de desconocido: Secuencia de Kozak" <400> 78 gccrccaugg 10 <210> 79 <211> 13 <212> ARN <213> Desconocido <220> <221> fuente <223> /nota="Descripción de desconocido: Secuencia de Kozak" <400> 79 gccgccrcca ugg 13 <210> 80 <211> 56 <212> ADN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Cebador sintético" <400> 80 cactctttcc ctacacgacg ctcttccgat ctgttttgtt ccagagtcta tcaccg 56 <210> 81 <211> 52 <212> ADN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Cebador sintético" <400> 81 ggagttcaga cgtgtgctct tccgatctac acgaataaga gcaaatggga ac 52 <210> 82 <211> 55 <212> ADN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Cebador sintético" <400> 82 cactctttcc ctacacgacg ctcttccgat cttgcatttc atgagaccga aaaca 55 <210> 83 <211> 55 <212> ADN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Cebador sintético" <400> 83 ggagttcaga cgtgtgctct tccgatctgc tacagtagag ctgtacataa aactt 55 <210> 84 <211> 3783 <212> ADN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 84 tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca 60 cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg 120 ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc 180 accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcaggcgcc 240 attcgccatt caggctgcgc aactgttggg aagggcgatc ggtgcgggcc tcttcgctat 300 tacgccagct ggcgaaaggg ggatgtgctg caaggcgatt aagttgggta acgccagggt 360 tttcccagtc acgacgttgt aaaacgacgg ccagtgaatt ctaatacgac tcactatagg 420 gtcccgcagt cggcgtccag cggctctgct tgttcgtgtg tgtgtcgttg caggccttat 480 tcggatccat ggtgagcaag ggcgaggagc tgttcaccgg ggtggtgccc atcctggtcg 540 agctggacgg cgacgtaaac ggccacaagt tcagcgtgtc cggcgagggc gagggcgatg 600 ccacctacgg caagctgacc ctgaagttca tctgcaccac cggcaagctg cccgtgccct 660 ggcccaccct cgtgaccacc ctgacctacg gcgtgcagtg cttcagccgc taccccgacc 720 acatgaagca gcacgacttc ttcaagtccg ccatgcccga aggctacgtc caggagcgca 780 ccatcttctt caaggacgac ggcaactaca agacccgcgc cgaggtgaag ttcgagggcg 840 acaccctggt gaaccgcatc gagctgaagg gcatcgactt caaggaggac ggcaacatcc 900 tggggcacaa gctggagtac aactacaaca gccacaacgt ctatatcatg gccgacaagc 960 agaagaacgg catcaaggtg aacttcaaga tccgccacaa catcgaggac ggcagcgtgc 1020 agctcgccga ccactaccag cagaacaccc ccatcggcga cggccccgtg ctgctgcccg 1080 acaaccacta cctgagcacc cagtccgccc tgagcaaaga ccccaacgag aagcgcgatc 1140 acatggtcct gctggagttc gtgaccgccg ccgggatcac tctcggcatg gacgagctgt 1200 acaagtaata ggaattatgc agtctagcca tcacatttaa aagcatctca gcctaccatg 1260 agaataagag aaagaaaatg aagatcaata gcttattcat ctctttttct ttttcgttgg 1320 tgtaaagcca acaccctgtc taaaaaacat aaatttcttt aatcattttg cctcttttct 1380 ctgtgcttca attaataaaa aatggaaaga acctcgagaa aaaaaaaaaa aaaaaaaaaa 1440 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1500 aaaaaaaaaa aaaaaaaatc tagacttaag cttgatgagc tctagcttgg cgtaatcatg 1560 gtcatagctg tttcctgtgt gaaattgtta tccgctcaca attccacaca acatacgagc 1620 cggaagcata aagtgtaaag cctggggtgc ctaatgagtg agctaactca cattaattgc 1680 gttgcgctca ctgcccgctt tccagtcggg aaacctgtcg tgccagctgc attaatgaat 1740 cggccaacgc gcggggagag gcggtttgcg tattgggcgc tcttccgctt cctcgctcac 1800 tgactcgctg cgctcggtcg ttcggctgcg gcgagcggta tcagctcact caaaggcggt 1860 aatacggtta tccacagaat caggggataa cgcaggaaag aacatgtgag caaaaggcca 1920 gcaaaaggcc aggaaccgta aaaaggccgc gttgctggcg tttttccata ggctccgccc 1980 ccctgacgag catcacaaaa atcgacgctc aagtcagagg tggcgaaacc cgacaggact 2040 ataaagatac caggcgtttc cccctggaag ctccctcgtg cgctctcctg ttccgaccct 2100 gccgcttacc ggatacctgt ccgcctttct cccttcggga agcgtggcgc tttctcatag 2160 ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca 2220 cgaacccccc gttcagcccg accgctgcgc cttatccggt aactatcgtc ttgagtccaa 2280 cccggtaaga cacgacttat cgccactggc agcagccact ggtaacagga ttagcagagc 2340 gaggtatgta ggcggtgcta cagagttctt gaagtggtgg cctaactacg gctacactag 2400 aagaacagta tttggtatct gcgctctgct gaagccagtt accttcggaa aaagagttgg 2460 tagctcttga tccggcaaac aaaccaccgc tggtagcggt ggtttttttg tttgcaagca 2520 gcagattacg cgcagaaaaa aaggatctca agaagatcct ttgatctttt ctacggggtc 2580 tgacgctcag tggaacgaaa actcacgtta agggattttg gtcatgagat tatcaaaaag 2640 gatcttcacc tagatccttt taaattaaaa atgaagtttt aaatcaatct aaagtatata 2700 tgagtaaact tggtctgaca gttaccaatg cttaatcagt gaggcaccta tctcagcgat 2760 ctgtctattt cgttcatcca tagttgcctg actccccgtc gtgtagataa ctacgatacg 2820 ggagggctta ccatctggcc ccagtgctgc aatgataccg cgagacccac gctcaccggc 2880 tccagattta tcagcaataa accagccagc cggaagggcc gagcgcagaa gtggtcctgc 2940 aactttatcc gcctccatcc agtctattaa ttgttgccgg gaagctagag taagtagttc 3000 gccagttaat agtttgcgca acgttgttgc cattgctaca ggcatcgtgg tgtcacgctc 3060 gtcgtttggt atggcttcat tcagctccgg ttcccaacga tcaaggcgag ttacatgatc 3120 ccccatgttg tgcaaaaaag cggttagctc cttcggtcct ccgatcgttg tcagaagtaa 3180 gttggccgca gtgttatcac tcatggttat ggcagcactg cataattctc ttactgtcat 3240 gccatccgta agatgctttt ctgtgactgg tgagtactca accaagtcat tctgagaata 3300 gtgtatgcgg cgaccgagtt gctcttgccc ggcgtcaata cgggataata ccgcgccaca 3360 tagcagaact ttaaaagtgc tcatcattgg aaaacgttct tcggggcgaa aactctcaag 3420 gatcttaccg ctgttgagat ccagttcgat gtaacccact cgtgcaccca actgatcttc 3480 agcatctttt actttcacca gcgtttctgg gtgagcaaaa acaggaaggc aaaatgccgc 3540 aaaaaaggga ataagggcga cacggaaatg ttgaatactc atactcttcc tttttcaata 3600 ttattgaagc atttatcagg gttattgtct catgagcgga tacatatttg aatgtattta 3660 gaaaaataaa caaatagggg ttccgcgcac atttccccga aaagtgccac ctgacgtcta 3720 agaaaccatt attatcatga cattaaccta taaaaatagg cgtatcacga ggccctttcg 3780 tcg 3783