LISTADO DE SECUENCIAS <110> PROTHENA BIOSCIENCES, INC. SALMANS, JOSHUA R. ALEXANDER, SVETLANA BARBOUR, ROBIN HIGAKI, JEFFREY N. NIJJAR, TARLOCHAN <120> ANTICUERPOS ANTI-TRANSTIRETINA <130> 057450-516711 <150> US 62/569,436 <151> 2017-10-06 <150> US 62/598,965 <151> 2017-12-14 <160> 102 <170> PatentIn version 3.5 <210> 1 <211> 139 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 1 Met Asp Phe Gly Leu Ile Phe Phe Ile Val Ala Leu Leu Lys Gly Val 1 5 10 15 Gln Cys Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 20 25 30 Gly Gly Ser Leu Asn Leu Ser Cys Val Ala Ser Gly Phe Asp Phe Ser 35 40 45 Arg Phe Trp Met Ser Trp Ala Arg Gln Ala Pro Gly Arg Gly Gln Glu 50 55 60 Trp Ile Gly Glu Ile Asn Pro Gly Ser Ser Thr Ile Asn Tyr Thr Pro 65 70 75 80 Ser Leu Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr 85 90 95 Leu Phe Leu Gln Met Ser Lys Val Arg Ser Glu Asp Ser Ala Leu Tyr 100 105 110 Tyr Cys Ala Arg Leu Gly Tyr Gly Asn Tyr Gly Trp Ala Leu Asp Tyr 115 120 125 Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 130 135 <210> 2 <211> 417 <212> ADN <213> Secuencia artificial <220> <223> Sintetizado <400> 2 atggattttg ggctgatttt tttcattgtt gcccttttaa aaggggtcca gtgtgaggta 60 aagcttctcg agtctggagg tggcctggtg cagcctggag gatccctgaa tctctcctgt 120 gtagcctcag gattcgattt tagtagattc tggatgagtt gggctcggca ggctccaggg 180 agaggacagg aatggattgg agagattaat ccaggaagca gtacgataaa ctatacgcca 240 tctctgaagg ataaattcat catctccaga gacaacgcca aaaatacgct gttcctgcaa 300 atgagcaaag tgagatctga ggactcagcc ctttattact gtgcaagact ggggtatggt 360 aactacggat gggctctgga ctactggggt caaggaacct cagtcaccgt ctcctca 417 <210> 3 <211> 131 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 3 Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 1 5 10 15 Ser Arg Ser Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val 20 25 30 Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile 35 40 45 Val Asp Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro 50 55 60 Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 65 70 75 80 Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 85 90 95 Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys 100 105 110 Phe Gln Gly Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu 115 120 125 Glu Leu Lys 130 <210> 4 <211> 393 <212> ADN <213> Secuencia artificial <220> <223> Sintetizado <400> 4 atgaagttgc ctgttaggct gttggtgctg atgttctgga ttcctgcttc cagaagtgat 60 gttttgatga cccaaactcc actctccctg cctgtcagtc ttggagatca agcctccatc 120 tcttgcagat ctagtcagag cattgtagat agtaatggaa acacctattt agaatggtac 180 ctgcagaaac caggccagtc tccaaagctc ctgatctaca aagtttccaa ccgattttct 240 ggggtcccag acaggttcag tggcagtgga tcagggacag atttcacact caagatcagc 300 agagtggagg ctgaggatct gggaatttat tactgctttc aaggttcaca tgttccgctc 360 acgttcggtg ctgggaccaa gttggagctg aaa 393 <210> 5 <211> 10 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 5 Gly Phe Asp Phe Ser Arg Phe Trp Met Ser 1 5 10 <210> 6 <211> 30 <212> ADN <213> Secuencia artificial <220> <223> Sintetizado <400> 6 ggattcgatt ttagtagatt ctggatgagt 30 <210> 7 <211> 17 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 7 Glu Ile Asn Pro Gly Ser Ser Thr Ile Asn Tyr Thr Pro Ser Leu Lys 1 5 10 15 Asp <210> 8 <211> 51 <212> ADN <213> Secuencia artificial <220> <223> Sintetizado <400> 8 gagattaatc caggaagcag tacgataaac tatacgccat ctctgaagga t 51 <210> 9 <211> 12 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 9 Leu Gly Tyr Gly Asn Tyr Gly Trp Ala Leu Asp Tyr 1 5 10 <210> 10 <211> 36 <212> ADN <213> Secuencia artificial <220> <223> Sintetizado <400> 10 ctggggtatg gtaactacgg atgggctctg gactac 36 <210> 11 <211> 16 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 11 Arg Ser Ser Gln Ser Ile Val Asp Ser Asn Gly Asn Thr Tyr Leu Glu 1 5 10 15 <210> 12 <211> 48 <212> ADN <213> Secuencia artificial <220> <223> Sintetizado <400> 12 agatctagtc agagcattgt agatagtaat ggaaacacct atttagaa 48 <210> 13 <211> 7 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 13 Lys Val Ser Asn Arg Phe Ser 1 5 <210> 14 <211> 21 <212> ADN <213> Secuencia artificial <220> <223> Sintetizado <400> 14 aaagtttcca accgattttc t 21 <210> 15 <211> 9 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 15 Phe Gln Gly Ser His Val Pro Leu Thr 1 5 <210> 16 <211> 27 <212> ADN <213> Secuencia artificial <220> <223> Sintetizado <400> 16 tttcaaggtt cacatgttcc gctcacg 27 <210> 17 <211> 330 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 17 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 1 5 10 15 Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 65 70 75 80 Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 100 105 110 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 115 120 125 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 130 135 140 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 145 150 155 160 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 165 170 175 Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 180 185 190 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 195 200 205 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 210 215 220 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 225 230 235 240 Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 245 250 255 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 260 265 270 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 275 280 285 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 290 295 300 Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 305 310 315 320 Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 325 330 <210> 18 <211> 993 <212> ADN <213> Secuencia artificial <220> <223> Sintetizado <400> 18 gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg 60 ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg 120 tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca 180 ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc 240 tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc 300 aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga 360 ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct 420 gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg 480 tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac 540 agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag 600 gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc 660 aaagccaaag ggcagccccg agaaccacag gtgtacacgc tgcccccatc ccgggaggag 720 atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc 780 gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg 840 ctggactccg acggctcctt cttcctctat agcaagctca ccgtggacaa gagcaggtgg 900 cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg 960 cagaagagcc tctccctgtc cccgggtaaa tga 993 <210> 19 <211> 107 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 19 Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 1 5 10 15 Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 20 25 30 Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 35 40 45 Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 50 55 60 Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 65 70 75 80 Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 85 90 95 Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 100 105 <210> 20 <211> 327 <212> ADN <213> Secuencia artificial <220> <223> Sintetizado <400> 20 cggggaactg tggctgcacc atctgtcttc atcttcccgc catctgatga gcagttgaaa 60 tctggaactg cctctgttgt gtgcctgctg aataacttct atcccagaga ggccaaagta 120 cagtggaagg tggataacgc cctccaatcg ggtaactccc aggagagtgt cacagagcag 180 gacagcaagg acagcaccta cagcctcagc agcaccctga cgctgagcaa agcagactac 240 gagaaacaca aagtctacgc ctgcgaagtc acccatcagg gcctgagctc gcccgtcaca 300 aagagcttca acaggggaga gtgttag 327 <210> 21 <211> 330 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 21 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 1 5 10 15 Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 65 70 75 80 Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 100 105 110 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 115 120 125 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 130 135 140 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 145 150 155 160 Tyr Val Asp Gly Val Glu Val His Asn Val Lys Thr Lys Pro Arg Glu 165 170 175 Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 180 185 190 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 195 200 205 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 210 215 220 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 225 230 235 240 Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 245 250 255 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 260 265 270 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 275 280 285 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 290 295 300 Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 305 310 315 320 Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 325 330 <210> 22 <211> 330 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 22 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 1 5 10 15 Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 65 70 75 80 Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 100 105 110 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 115 120 125 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 130 135 140 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 145 150 155 160 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 165 170 175 Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 180 185 190 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 195 200 205 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 210 215 220 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 225 230 235 240 Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 245 250 255 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 260 265 270 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 275 280 285 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 290 295 300 Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 305 310 315 320 Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 325 330 <210> 23 <211> 330 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 23 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 1 5 10 15 Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 65 70 75 80 Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 100 105 110 Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 115 120 125 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 130 135 140 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 145 150 155 160 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 165 170 175 Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 180 185 190 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 195 200 205 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 210 215 220 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 225 230 235 240 Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 245 250 255 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 260 265 270 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 275 280 285 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 290 295 300 Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 305 310 315 320 Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 325 330 <210> 24 <211> 107 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 24 Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 1 5 10 15 Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 20 25 30 Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 35 40 45 Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 50 55 60 Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 65 70 75 80 Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 85 90 95 Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 100 105 <210> 25 <211> 106 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 25 Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 1 5 10 15 Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 20 25 30 Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 35 40 45 Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 50 55 60 Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 65 70 75 80 His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 85 90 95 Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 100 105 <210> 26 <211> 147 <212> PRT <213> Homo sapiens <400> 26 Met Ala Ser His Arg Leu Leu Leu Leu Cys Leu Ala Gly Leu Val Phe 1 5 10 15 Val Ser Glu Ala Gly Pro Thr Gly Thr Gly Glu Ser Lys Cys Pro Leu 20 25 30 Met Val Lys Val Leu Asp Ala Val Arg Gly Ser Pro Ala Ile Asn Val 35 40 45 Ala Val His Val Phe Arg Lys Ala Ala Asp Asp Thr Trp Glu Pro Phe 50 55 60 Ala Ser Gly Lys Thr Ser Glu Ser Gly Glu Leu His Gly Leu Thr Thr 65 70 75 80 Glu Glu Glu Phe Val Glu Gly Ile Tyr Lys Val Glu Ile Asp Thr Lys 85 90 95 Ser Tyr Trp Lys Ala Leu Gly Ile Ser Pro Phe His Glu His Ala Glu 100 105 110 Val Val Phe Thr Ala Asn Asp Ser Gly Pro Arg Arg Tyr Thr Ile Ala 115 120 125 Ala Leu Leu Ser Pro Tyr Ser Tyr Ser Thr Thr Ala Val Val Thr Asn 130 135 140 Pro Lys Glu 145 <210> 27 <211> 127 <212> PRT <213> Homo sapiens <400> 27 Gly Pro Thr Gly Thr Gly Glu Ser Lys Cys Pro Leu Met Val Lys Val 1 5 10 15 Leu Asp Ala Val Arg Gly Ser Pro Ala Ile Asn Val Ala Val His Val 20 25 30 Phe Arg Lys Ala Ala Asp Asp Thr Trp Glu Pro Phe Ala Ser Gly Lys 35 40 45 Thr Ser Glu Ser Gly Glu Leu His Gly Leu Thr Thr Glu Glu Gln Phe 50 55 60 Val Glu Gly Ile Tyr Lys Val Glu Ile Asp Thr Lys Ser Tyr Trp Lys 65 70 75 80 Ala Leu Gly Ile Ser Pro Phe His Glu His Ala Glu Val Val Phe Thr 85 90 95 Ala Asn Asp Ser Gly Pro Arg Arg Tyr Thr Ile Ala Ala Leu Leu Ser 100 105 110 Pro Tyr Ser Tyr Ser Thr Thr Ala Val Val Thr Asn Pro Lys Glu 115 120 125 <210> 28 <211> 127 <212> PRT <213> Homo sapiens <400> 28 Gly Pro Thr Gly Thr Gly Glu Ser Lys Cys Pro Leu Met Val Lys Val 1 5 10 15 Leu Asp Ala Val Arg Gly Ser Pro Ala Ile Asn Val Ala Val His Val 20 25 30 Phe Arg Lys Ala Ala Asp Asp Thr Trp Glu Pro Phe Ala Ser Gly Lys 35 40 45 Thr Ser Glu Ser Gly Glu Leu His Gly Leu Thr Thr Glu Glu Gln Phe 50 55 60 Val Glu Gly Ile Tyr Lys Val Glu Ile Asp Thr Lys Ser Tyr Trp Lys 65 70 75 80 Ala Leu Gly Ile Ser Pro Phe His Glu His Ala Glu Val Val Phe Thr 85 90 95 Ala Asn Asp Ser Gly Pro Arg Arg Tyr Thr Ile Ala Ala Leu Leu Ser 100 105 110 Pro Tyr Ser Tyr Ser Thr Thr Ala Val Val Thr Asn Pro Lys Glu 115 120 125 <210> 29 <211> 138 <212> PRT <213> Homo sapiens <400> 29 Met Ala Ser His Arg Leu Leu Leu Leu Cys Leu Ala Gly Leu Val Phe 1 5 10 15 Val Ser Glu Ala Gly Pro Thr Gly Thr Gly Glu Ser Lys Cys Pro Leu 20 25 30 Met Val Lys Val Leu Asp Ala Val Arg Gly Ser Pro Ala Ile Asn Val 35 40 45 Ala Val His Val Phe Arg Lys Ala Ala Asp Asp Thr Trp Glu Pro Phe 50 55 60 Ala Ser Gly Lys Thr Ser Glu Ser Gly Glu Leu His Gly Leu Thr Thr 65 70 75 80 Glu Glu Glu Phe Val Glu Gly Ile Tyr Lys Val Glu Ile Asp Thr Lys 85 90 95 Ser Tyr Trp Lys Ala Leu Gly Ile Ser Pro Phe His Glu His Ala Glu 100 105 110 Val Val Phe Thr Ala Asn Asp Ser Gly Pro Arg Arg Tyr Ser Tyr Ser 115 120 125 Thr Thr Ala Val Val Thr Asn Pro Lys Glu 130 135 <210> 30 <211> 9 <212> PRT <213> Homo sapiens <400> 30 Gly Pro Arg Arg Tyr Thr Ile Ala Ala 1 5 <210> 31 <211> 41 <212> PRT <213> Homo sapiens <400> 31 Phe His Glu His Ala Glu Val Val Phe Thr Ala Asn Asp Ser Gly Pro 1 5 10 15 Arg Arg Tyr Thr Ile Ala Ala Leu Leu Ser Pro Tyr Ser Tyr Ser Thr 20 25 30 Thr Ala Val Val Thr Asn Pro Lys Glu 35 40 <210> 32 <211> 990 <212> ADN <213> Secuencia artificial <220> <223> Sintetizado <400> 32 gcctccacca agggtccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg 60 ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg 120 tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca 180 ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc 240 tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc 300 aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga 360 ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct 420 gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg 480 tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac 540 agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag 600 gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc 660 aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag 720 atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc 780 gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg 840 ctggactccg acggctcctt cttcctctat agcaagctca ccgtggacaa gagcaggtgg 900 cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg 960 cagaagagcc tctccctgtc cccgggtaaa 990 <210> 33 <211> 321 <212> ADN <213> Secuencia artificial <220> <223> Sintetizado <400> 33 cgaactgtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct 60 ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag 120 tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac 180 agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag 240 aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag 300 agcttcaaca ggggagagtg t 321 <210> 34 <211> 318 <212> ADN <213> Secuencia artificial <220> <223> Sintetizado <400> 34 actgtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga 60 actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg 120 aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc 180 aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa 240 cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc 300 ttcaacaggg gagagtgt 318 <210> 35 <211> 19 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 35 Met Asn Phe Gly Leu Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 1 5 10 15 Val Gln Cys <210> 36 <211> 57 <212> ADN <213> Secuencia artificial <220> <223> Sintetizado <400> 36 atgaactttg ggctcagctt gattttcctt gtccttgttt taaaaggtgt ccagtgt 57 <210> 37 <211> 20 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 37 Met Glu Ser His Thr Gln Val Phe Val Phe Val Phe Leu Trp Leu Ser 1 5 10 15 Gly Val Asp Gly 20 <210> 38 <211> 60 <212> ADN <213> Secuencia artificial <220> <223> Sintetizado <400> 38 atggagtcac atactcaggt ctttgtattc gtgtttctct ggttgtctgg tgttgacgga 60 <210> 39 <211> 5 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 39 Ser Tyr Thr Met Ser 1 5 <210> 40 <211> 17 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 40 Glu Ile Asn Asn Ser Gly Asp Thr Thr Tyr Tyr Pro Asp Thr Val Lys 1 5 10 15 Gly <210> 41 <211> 15 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 41 His Tyr Tyr Tyr Gly Gly Gly Tyr Gly Gly Trp Phe Phe Asp Val 1 5 10 15 <210> 42 <211> 16 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 42 Arg Ser Asn Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr 1 5 10 15 <210> 43 <211> 7 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 43 Arg Val Ser Asn Leu Ala Ser 1 5 <210> 44 <211> 9 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 44 Met Gln His Leu Glu Tyr Pro Leu Thr 1 5 <210> 45 <211> 9 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 45 Glu His Ala Glu Val Val Phe Thr Ala 1 5 <210> 46 <211> 5 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 46 Asn Tyr Ala Met Ser 1 5 <210> 47 <211> 16 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 47 Ser Ile Ser Ser Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val Lys Gly 1 5 10 15 <210> 48 <211> 9 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 48 Tyr Tyr Tyr Gly Gln Tyr Phe Asp Phe 1 5 <210> 49 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 49 Lys Ala Ser Gln Asp Val Ser Thr Thr Val Ala 1 5 10 <210> 50 <211> 7 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 50 Ser Ala Ser Tyr Arg Cys Thr 1 5 <210> 51 <211> 9 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 51 Gln Gln His Tyr Ser Thr Pro Leu Thr 1 5 <210> 52 <211> 5 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 52 Asn Tyr Tyr Met Ser 1 5 <210> 53 <211> 17 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 53 Tyr Ile Ser Ile Asp Gly Asn Asn Ile Tyr His Pro Asp Ser Val Lys 1 5 10 15 Gly <210> 54 <211> 9 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 54 Asp Ser Asp Tyr Gly Tyr Phe Asp Val 1 5 <210> 55 <211> 16 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 55 Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 1 5 10 15 <210> 56 <211> 7 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 56 Lys Val Ser Lys Arg Phe Ser 1 5 <210> 57 <211> 9 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 57 Phe Gln Gly Ser His Val Pro Leu Thr 1 5 <210> 58 <211> 455 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 58 Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 1 5 10 15 Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Gly Met Ser Trp Ile Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 35 40 45 Ala Thr Ile Ser Ser Ser Gly Thr Tyr Thr Tyr Tyr Thr Glu Ser Val 50 55 60 Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Leu Ser 65 70 75 80 Leu Gln Met Ser Asn Leu Lys Ser Asp Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Thr Arg Gln Ala Tyr Gly Arg Glu Tyr Phe Asp Val Trp Gly Thr Gly 100 105 110 Thr Thr Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr 115 120 125 Pro Leu Ala Pro Gly Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu 130 135 140 Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Ser Val Thr Val Thr Trp 145 150 155 160 Asn Ser Gly Ser Leu Ser Ser Ser Val His Thr Phe Pro Ala Leu Leu 165 170 175 Gln Ser Gly Leu Tyr Thr Met Ser Ser Ser Val Thr Val Pro Ser Ser 180 185 190 Thr Trp Pro Ser Gln Thr Val Thr Cys Ser Val Ala His Pro Ala Ser 195 200 205 Ser Thr Thr Val Asp Lys Lys Leu Glu Pro Ser Gly Pro Ile Ser Thr 210 215 220 Ile Asn Pro Cys Pro Pro Cys Lys Glu Cys His Lys Cys Pro Ala Pro 225 230 235 240 Asn Leu Glu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Asn Ile Lys 245 250 255 Asp Val Leu Met Ile Ser Leu Thr Pro Lys Val Thr Cys Val Val Val 260 265 270 Asp Val Ser Glu Asp Asp Pro Asp Val Arg Ile Ser Trp Phe Val Asn 275 280 285 Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr 290 295 300 Asn Ser Thr Ile Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp 305 310 315 320 Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu 325 330 335 Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ile Lys Gly Leu Val Arg 340 345 350 Ala Pro Gln Val Tyr Ile Leu Pro Pro Pro Ala Glu Gln Leu Ser Arg 355 360 365 Lys Asp Val Ser Leu Thr Cys Leu Val Val Gly Phe Asn Pro Gly Asp 370 375 380 Ile Ser Val Glu Trp Thr Ser Asn Gly His Thr Glu Glu Asn Tyr Lys 385 390 395 400 Asp Thr Ala Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Ile Tyr Ser 405 410 415 Lys Leu Asp Ile Lys Thr Ser Thr Val Gly Glu Asn Arg Phe Leu Leu 420 425 430 Met Gln Arg Glu Thr Arg Gly Ser Glu Lys Leu Leu Pro Glu Glu Asp 435 440 445 His Leu Pro Ser Pro Gly Lys 450 455 <210> 59 <211> 219 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 59 Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 1 5 10 15 Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Phe Asp Ser 20 25 30 Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 35 40 45 Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Asn Arg Glu Ser Gly Val 50 55 60 Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 65 70 75 80 Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Phe Cys Lys Gln 85 90 95 Ser Asn Tyr Leu Arg Thr Phe Gly Gly Gly Thr Arg Val Glu Ile Lys 100 105 110 Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 115 120 125 Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 130 135 140 Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 145 150 155 160 Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 165 170 175 Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 180 185 190 Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 195 200 205 Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 210 215 <210> 60 <211> 5 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 60 Arg Tyr Trp Ile Thr 1 5 <210> 61 <211> 17 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 61 Asp Ile Tyr Pro Gly Ser Gly Arg Thr Asn Tyr Asn Glu Lys Phe Lys 1 5 10 15 Asn <210> 62 <211> 9 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 62 Tyr Tyr Gly Ser Thr Tyr Phe Tyr Val 1 5 <210> 63 <211> 16 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 63 Arg Ser Ser Lys Ser Leu Leu Tyr Lys Asp Gly Lys Thr Tyr Leu Asn 1 5 10 15 <210> 64 <211> 7 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 64 Leu Met Ser Thr Arg Ala Ser 1 5 <210> 65 <211> 9 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 65 Gln Gln Leu Val Glu Tyr Pro Arg Thr 1 5 <210> 66 <211> 5 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 66 Ser Tyr Ala Met Ser 1 5 <210> 67 <211> 17 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 67 Ser Ile Ser Gly Ser Gly Asp Thr Thr Lys Tyr Thr Asp Ser Val Lys 1 5 10 15 Gly <210> 68 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 68 Asp Gly Ser Gly Arg Ile Asp Pro Phe Ala Leu 1 5 10 <210> 69 <211> 16 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 69 Arg Ser Ser Arg Ser Leu Val Tyr Ser Asp Gly Asn Ile Tyr Leu Asn 1 5 10 15 <210> 70 <211> 8 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 70 Lys Val Ser Asn Arg Asp Ser Gly 1 5 <210> 71 <211> 9 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 71 Met Gln Gly Thr His Trp Pro Arg Thr 1 5 <210> 72 <211> 13 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 72 Ala Asp Asp Thr Trp Glu Pro Phe Ala Ser Gly Lys Thr 1 5 10 <210> 73 <211> 13 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 73 Thr Ser Glu Ser Gly Glu Leu His Gly Leu Thr Thr Glu 1 5 10 <210> 74 <211> 13 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 74 Ala Leu Leu Ser Pro Tyr Ser Tyr Ser Thr Thr Ala Val 1 5 10 <210> 75 <211> 5 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 75 Ser Tyr Thr Met Ser 1 5 <210> 76 <211> 17 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 76 Glu Ile Ser Asn Ser Gly Asp Thr Thr Tyr Tyr Pro Asp Thr Val Lys 1 5 10 15 Gly <210> 77 <211> 15 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 77 His Tyr Tyr Tyr Gly Gly Gly Tyr Gly Gly Trp Phe Phe Asp Val 1 5 10 15 <210> 78 <211> 16 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 78 Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr 1 5 10 15 <210> 79 <211> 7 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 79 Arg Val Ser Asn Leu Ala Ser 1 5 <210> 80 <211> 9 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 80 Met Gln His Leu Glu Tyr Pro Leu Thr 1 5 <210> 81 <211> 121 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 81 Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Asn Leu Ser Cys Val Ala Ser Gly Phe Asp Phe Ser Arg Phe 20 25 30 Trp Met Ser Trp Ala Arg Gln Ala Pro Gly Arg Gly Gln Glu Trp Ile 35 40 45 Gly Glu Ile Asn Pro Gly Ser Ser Thr Ile Asn Tyr Thr Pro Ser Leu 50 55 60 Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe 65 70 75 80 Leu Gln Met Ser Lys Val Arg Ser Glu Asp Ser Ala Leu Tyr Tyr Cys 85 90 95 Ala Arg Leu Gly Tyr Gly Asn Tyr Gly Trp Ala Leu Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Ser Val Thr Val Ser Ser 115 120 <210> 82 <211> 122 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 82 Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 20 25 30 Gly Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 35 40 45 Ala Phe Ile Ser Asn Leu Ala Tyr Ser Ile Tyr Tyr Ala Asp Thr Val 50 55 60 Thr Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Ala Arg Tyr Asp Tyr Asp Asn Ile Leu Asp Tyr Val Met Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Ser Val Thr Val Ser Ser 115 120 <210> 83 <211> 112 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 83 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val 35 40 45 Ala Ser Ile Asn Ser Asn Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Ser Gly Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 100 105 110 <210> 84 <211> 113 <212> PRT <213> Homo sapiens <400> 84 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 100 105 110 Ser <210> 85 <211> 121 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 85 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Arg Phe 20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val 35 40 45 Ala Glu Ile Asn Pro Gly Ser Ser Thr Ile Asn Tyr Thr Pro Ser Leu 50 55 60 Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Ser Leu Gly Tyr Gly Asn Tyr Gly Trp Ala Leu Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 86 <211> 121 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 86 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Arg Phe 20 25 30 Trp Met Ser Trp Ala Arg Gln Ala Pro Gly Lys Gly Gln Glu Trp Ile 35 40 45 Gly Glu Ile Asn Pro Gly Ser Ser Thr Ile Asn Tyr Thr Pro Ser Leu 50 55 60 Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Leu Gly Tyr Gly Asn Tyr Gly Trp Ala Leu Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 87 <211> 112 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 87 Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 1 5 10 15 Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val Asp Ser 20 25 30 Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys Phe Gln Gly 85 90 95 Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 100 105 110 <210> 88 <211> 112 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 88 Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 1 5 10 15 Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 20 25 30 Asp Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 85 90 95 Thr His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 89 <211> 112 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 89 Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 20 25 30 Asn Gly Asp Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 85 90 95 Thr His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 90 <211> 112 <212> PRT <213> Homo sapiens <400> 90 Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 1 5 10 15 Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 20 25 30 Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 35 40 45 Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 85 90 95 Thr His Trp Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 91 <211> 112 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 91 Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val Asp Ser 20 25 30 Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 85 90 95 Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 92 <211> 112 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 92 Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val Asp Ser 20 25 30 Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 85 90 95 Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 93 <211> 5 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 93 Arg Phe Trp Met Ser 1 5 <210> 94 <211> 7 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 94 Gly Phe Asp Phe Ser Arg Phe 1 5 <210> 95 <211> 6 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 95 Ser Arg Phe Trp Met Ser 1 5 <210> 96 <211> 6 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 96 Asn Pro Gly Ser Ser Thr 1 5 <210> 97 <211> 10 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 97 Glu Ile Asn Pro Gly Ser Ser Thr Ile Asn 1 5 10 <210> 98 <211> 13 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 98 Trp Ile Gly Glu Ile Asn Pro Gly Ser Ser Thr Ile Asn 1 5 10 <210> 99 <211> 13 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 99 Ala Arg Leu Gly Tyr Gly Asn Tyr Gly Trp Ala Leu Asp 1 5 10 <210> 100 <211> 7 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 100 Asn Thr Tyr Leu Glu Trp Tyr 1 5 <210> 101 <211> 10 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 101 Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe 1 5 10 <210> 102 <211> 8 <212> PRT <213> Secuencia artificial <220> <223> Sintetizado <400> 102 Phe Gln Gly Ser His Val Pro Leu 1 5