LISTADO DE SECUENCIAS <110> Merck Sharp & Dohme Corp. Ryan, Michael S. Martin, Sherrie-Ann P. Jones, Morrisa C. Stanbro, Justin Bhambhani, Akhilesh Blue, Jeffrey Thomas Pixley, Heidi Joanne Green-Trexler, Erin, J. Isopi, Lynne Anne <120> FORMULACIONES DE VACUNA DEL VIRUS DEL DENGUE <130> 24547-WO-PCT <160> 9 <170> PatentIn version 3.5 <210> 1 <211> 395 <212> PRT <213> Dengue 1 <400> 1 Met Arg Cys Val Gly Ile Gly Ser Arg Asp Phe Val Glu Gly Leu Ser 1 5 10 15 Gly Ala Thr Trp Val Asp Val Val Leu Glu His Gly Ser Cys Val Thr 20 25 30 Thr Met Ala Lys Asp Lys Pro Thr Leu Asp Ile Glu Leu Leu Lys Thr 35 40 45 Glu Val Thr Asn Pro Ala Val Leu Arg Lys Leu Cys Ile Glu Ala Lys 50 55 60 Ile Ser Asn Thr Thr Thr Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 65 70 75 80 Thr Leu Val Glu Glu Gln Asp Ala Asn Phe Val Cys Arg Arg Thr Phe 85 90 95 Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 100 105 110 Leu Ile Thr Cys Ala Lys Phe Lys Cys Val Thr Lys Leu Glu Gly Lys 115 120 125 Ile Val Gln Tyr Glu Asn Leu Lys Tyr Ser Val Ile Val Thr Val His 130 135 140 Thr Gly Asp Gln His Gln Val Gly Asn Glu Ser Thr Glu His Gly Thr 145 150 155 160 Thr Ala Thr Ile Thr Pro Gln Ala Pro Thr Ser Glu Ile Gln Leu Thr 165 170 175 Asp Tyr Gly Ala Leu Thr Leu Asp Cys Ser Pro Arg Thr Gly Leu Asp 180 185 190 Phe Asn Glu Met Val Leu Leu Thr Met Lys Glu Lys Ser Trp Leu Val 195 200 205 His Lys Gln Trp Phe Leu Asp Leu Pro Leu Pro Trp Thr Ser Gly Ala 210 215 220 Ser Thr Ser Gln Glu Thr Trp Asn Arg Gln Asp Leu Leu Val Thr Phe 225 230 235 240 Lys Thr Ala His Ala Lys Lys Gln Glu Val Val Val Leu Gly Ser Gln 245 250 255 Glu Gly Ala Met His Thr Ala Leu Thr Gly Ala Thr Glu Ile Gln Thr 260 265 270 Ser Gly Thr Thr Thr Ile Phe Ala Gly His Leu Lys Cys Arg Leu Lys 275 280 285 Met Asp Lys Leu Thr Leu Lys Gly Met Ser Tyr Val Met Cys Thr Gly 290 295 300 Ser Phe Lys Leu Glu Lys Glu Val Ala Glu Thr Gln His Gly Thr Val 305 310 315 320 Leu Val Gln Ile Lys Tyr Glu Gly Thr Asp Ala Pro Cys Lys Ile Pro 325 330 335 Phe Ser Thr Gln Asp Glu Arg Gly Val Thr Gln Asn Gly Arg Leu Ile 340 345 350 Thr Ala Asn Pro Ile Val Thr Asp Lys Glu Lys Pro Val Asn Ile Glu 355 360 365 Ala Glu Pro Pro Phe Gly Glu Ser Tyr Ile Val Ile Gly Ala Gly Glu 370 375 380 Lys Ala Leu Lys Leu Ser Trp Phe Lys Lys Gly 385 390 395 <210> 2 <211> 395 <212> PRT <213> Dengue 2 <400> 2 Met Arg Cys Ile Gly Ile Ser Asn Arg Asp Phe Val Glu Gly Val Ser 1 5 10 15 Gly Gly Ser Trp Val Asp Ile Val Leu Glu His Gly Ser Cys Val Thr 20 25 30 Thr Met Ala Lys Asn Lys Pro Thr Leu Asp Phe Glu Leu Ile Lys Thr 35 40 45 Glu Ala Lys Gln Pro Ala Thr Leu Arg Lys Tyr Cys Ile Glu Ala Lys 50 55 60 Leu Thr Asn Thr Thr Thr Asp Ser Arg Cys Pro Thr Gln Gly Glu Pro 65 70 75 80 Thr Leu Asn Glu Glu Gln Asp Lys Arg Phe Val Cys Lys His Ser Met 85 90 95 Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Gly 100 105 110 Ile Val Thr Cys Ala Met Phe Thr Cys Lys Lys Asn Met Glu Gly Lys 115 120 125 Ile Val Gln Pro Glu Asn Leu Glu Tyr Thr Val Val Ile Thr Pro His 130 135 140 Ser Gly Glu Glu His Ala Val Gly Asn Asp Thr Gly Lys His Gly Lys 145 150 155 160 Glu Val Lys Ile Thr Pro Gln Ser Ser Ile Thr Glu Ala Glu Leu Thr 165 170 175 Gly Tyr Gly Thr Val Thr Met Glu Cys Ser Pro Arg Thr Gly Leu Asp 180 185 190 Phe Asn Glu Met Val Leu Leu Gln Met Lys Asp Lys Ala Trp Leu Val 195 200 205 His Arg Gln Trp Phe Leu Asp Leu Pro Leu Pro Trp Leu Pro Gly Ala 210 215 220 Asp Thr Gln Gly Ser Asn Trp Ile Gln Lys Glu Thr Leu Val Thr Phe 225 230 235 240 Lys Asn Pro His Ala Lys Lys Gln Asp Val Val Val Leu Gly Ser Gln 245 250 255 Glu Gly Ala Met His Thr Ala Leu Thr Gly Ala Thr Glu Ile Gln Met 260 265 270 Ser Ser Gly Asn Leu Leu Phe Thr Gly His Leu Lys Cys Arg Leu Arg 275 280 285 Met Asp Lys Leu Gln Leu Lys Gly Met Ser Tyr Ser Met Cys Thr Gly 290 295 300 Lys Phe Lys Val Val Lys Glu Ile Ala Glu Thr Gln His Gly Thr Ile 305 310 315 320 Val Ile Arg Val Gln Tyr Glu Gly Asp Gly Ser Pro Cys Lys Ile Pro 325 330 335 Phe Glu Ile Met Asp Leu Glu Lys Arg His Val Leu Gly Arg Leu Ile 340 345 350 Thr Val Asn Pro Ile Val Thr Glu Lys Asp Ser Pro Val Asn Ile Glu 355 360 365 Ala Glu Pro Pro Phe Gly Asp Ser Tyr Ile Ile Ile Gly Val Glu Pro 370 375 380 Gly Gln Leu Lys Leu Asp Trp Phe Lys Lys Gly 385 390 395 <210> 3 <211> 393 <212> PRT <213> Dengue 3 <400> 3 Met Arg Cys Val Gly Val Gly Asn Arg Asp Phe Val Glu Gly Leu Ser 1 5 10 15 Gly Ala Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 20 25 30 Thr Met Ala Lys Asn Lys Pro Thr Leu Asp Ile Glu Leu Gln Lys Thr 35 40 45 Glu Ala Thr Gln Leu Ala Thr Leu Arg Lys Leu Cys Ile Glu Gly Lys 50 55 60 Ile Thr Asn Ile Thr Thr Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 65 70 75 80 Ile Leu Pro Glu Glu Gln Asp Gln Asn Tyr Val Cys Lys His Thr Tyr 85 90 95 Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 100 105 110 Leu Val Thr Cys Ala Lys Phe Gln Cys Leu Glu Ser Ile Glu Gly Lys 115 120 125 Val Val Gln His Glu Asn Leu Lys Tyr Thr Val Ile Ile Thr Val His 130 135 140 Thr Gly Asp Gln His Gln Val Gly Asn Glu Thr Gln Gly Val Thr Ala 145 150 155 160 Glu Ile Thr Pro Gln Ala Ser Thr Val Glu Ala Ile Leu Pro Glu Tyr 165 170 175 Gly Thr Leu Gly Leu Glu Cys Ser Pro Arg Thr Gly Leu Asp Phe Asn 180 185 190 Glu Met Ile Leu Leu Thr Met Lys Asn Lys Ala Trp Met Val His Arg 195 200 205 Gln Trp Phe Phe Asp Leu Pro Leu Pro Trp Thr Ser Gly Ala Thr Thr 210 215 220 Glu Thr Pro Thr Trp Asn Arg Lys Glu Leu Leu Val Thr Phe Lys Asn 225 230 235 240 Ala His Ala Lys Lys Gln Glu Val Val Val Leu Gly Ser Gln Glu Gly 245 250 255 Ala Met His Thr Ala Leu Thr Gly Ala Thr Glu Ile Gln Asn Ser Gly 260 265 270 Gly Thr Ser Ile Phe Ala Gly His Leu Lys Cys Arg Leu Lys Met Asp 275 280 285 Lys Leu Glu Leu Lys Gly Met Ser Tyr Ala Met Cys Leu Asn Thr Phe 290 295 300 Val Leu Lys Lys Glu Val Ser Glu Thr Gln His Gly Thr Ile Leu Ile 305 310 315 320 Lys Val Glu Tyr Lys Gly Glu Asp Ala Pro Cys Lys Ile Pro Phe Ser 325 330 335 Thr Glu Asp Gly Gln Gly Lys Ala His Asn Gly Arg Leu Ile Thr Ala 340 345 350 Asn Pro Val Val Thr Lys Lys Glu Glu Pro Val Asn Ile Glu Ala Glu 355 360 365 Pro Pro Phe Gly Glu Ser Asn Ile Val Ile Gly Ile Gly Asp Lys Ala 370 375 380 Leu Lys Ile Asn Trp Tyr Lys Lys Gly 385 390 <210> 4 <211> 395 <212> PRT <213> Dengue 4 <400> 4 Met Arg Cys Val Gly Val Gly Asn Arg Asp Phe Val Glu Gly Val Ser 1 5 10 15 Gly Gly Ala Trp Val Asp Leu Val Leu Glu His Gly Gly Cys Val Thr 20 25 30 Thr Met Ala Gln Gly Lys Pro Thr Leu Asp Phe Glu Leu Ile Lys Thr 35 40 45 Thr Ala Lys Glu Val Ala Leu Leu Arg Thr Tyr Cys Ile Glu Ala Ser 50 55 60 Ile Ser Asn Ile Thr Thr Ala Thr Arg Cys Pro Thr Gln Gly Glu Pro 65 70 75 80 Tyr Leu Lys Glu Glu Gln Asp Gln Gln Tyr Ile Cys Arg Arg Asp Val 85 90 95 Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Gly 100 105 110 Val Val Thr Cys Ala Lys Phe Ser Cys Ser Gly Lys Ile Thr Gly Asn 115 120 125 Leu Val Gln Ile Glu Asn Leu Glu Tyr Thr Val Val Val Thr Val His 130 135 140 Asn Gly Asp Thr His Ala Val Gly Asn Asp Thr Ser Asn His Gly Val 145 150 155 160 Thr Ala Thr Ile Thr Pro Arg Ser Pro Ser Val Glu Val Lys Leu Pro 165 170 175 Asp Tyr Gly Glu Leu Thr Leu Asp Cys Glu Pro Arg Ser Gly Ile Asp 180 185 190 Phe Asn Glu Met Ile Leu Met Lys Met Lys Lys Lys Thr Trp Leu Val 195 200 205 His Lys Gln Trp Phe Leu Asp Leu Pro Leu Pro Trp Ala Ala Gly Ala 210 215 220 Asp Thr Ser Glu Val His Trp Asn Tyr Lys Glu Arg Met Val Thr Phe 225 230 235 240 Lys Val Pro His Ala Lys Arg Gln Asp Val Thr Val Leu Gly Ser Gln 245 250 255 Glu Gly Ala Met His Ser Ala Leu Thr Gly Ala Thr Glu Val Asp Ser 260 265 270 Gly Asp Gly Asn His Met Tyr Ala Gly His Leu Lys Cys Lys Val Arg 275 280 285 Met Glu Lys Leu Arg Ile Lys Gly Met Ser Tyr Thr Met Cys Ser Gly 290 295 300 Lys Phe Ser Ile Asp Lys Glu Met Ala Glu Thr Gln His Gly Thr Thr 305 310 315 320 Val Val Lys Val Lys Tyr Glu Gly Ala Gly Ala Pro Cys Lys Val Pro 325 330 335 Ile Glu Ile Arg Asp Val Asn Lys Glu Lys Val Val Gly Arg Ile Ile 340 345 350 Ser Ser Thr Pro Phe Ala Glu Tyr Thr Asn Ser Val Thr Asn Ile Glu 355 360 365 Leu Glu Pro Pro Phe Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Asp 370 375 380 Ser Ala Leu Thr Leu His Trp Phe Arg Lys Gly 385 390 395 <210> 5 <211> 451 <212> PRT <213> Secuencia Artificial <220> <223> DEN4-80EZip <400> 5 Met Arg Cys Val Gly Val Gly Asn Arg Asp Phe Val Glu Gly Val Ser 1 5 10 15 Gly Gly Ala Trp Val Asp Leu Val Leu Glu His Gly Gly Cys Val Thr 20 25 30 Thr Met Ala Gln Gly Lys Pro Thr Leu Asp Phe Glu Leu Ile Lys Thr 35 40 45 Thr Ala Lys Glu Val Ala Leu Leu Arg Thr Tyr Cys Ile Glu Ala Ser 50 55 60 Ile Ser Asn Ile Thr Thr Ala Thr Arg Cys Pro Thr Gln Gly Glu Pro 65 70 75 80 Tyr Leu Lys Glu Glu Gln Asp Gln Gln Tyr Ile Cys Arg Arg Asp Val 85 90 95 Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Gly 100 105 110 Val Val Thr Cys Ala Lys Phe Ser Cys Ser Gly Lys Ile Thr Gly Asn 115 120 125 Leu Val Gln Ile Glu Asn Leu Glu Tyr Thr Val Val Val Thr Val His 130 135 140 Asn Gly Asp Thr His Ala Val Gly Asn Asp Thr Ser Asn His Gly Val 145 150 155 160 Thr Ala Thr Ile Thr Pro Arg Ser Pro Ser Val Glu Val Lys Leu Pro 165 170 175 Asp Tyr Gly Glu Leu Thr Leu Asp Cys Glu Pro Arg Ser Gly Ile Asp 180 185 190 Phe Asn Glu Met Ile Leu Met Lys Met Lys Lys Lys Thr Trp Leu Val 195 200 205 His Lys Gln Trp Phe Leu Asp Leu Pro Leu Pro Trp Ala Ala Gly Ala 210 215 220 Asp Thr Ser Glu Val His Trp Asn Tyr Lys Glu Arg Met Val Thr Phe 225 230 235 240 Lys Val Pro His Ala Lys Arg Gln Asp Val Thr Val Leu Gly Ser Gln 245 250 255 Glu Gly Ala Met His Ser Ala Leu Thr Gly Ala Thr Glu Val Asp Ser 260 265 270 Gly Asp Gly Asn His Met Tyr Ala Gly His Leu Lys Cys Lys Val Arg 275 280 285 Met Glu Lys Leu Arg Ile Lys Gly Met Ser Tyr Thr Met Cys Ser Gly 290 295 300 Lys Phe Ser Ile Asp Lys Glu Met Ala Glu Thr Gln His Gly Thr Thr 305 310 315 320 Val Val Lys Val Lys Tyr Glu Gly Ala Gly Ala Pro Cys Lys Val Pro 325 330 335 Ile Glu Ile Arg Asp Val Asn Lys Glu Lys Val Val Gly Arg Ile Ile 340 345 350 Ser Ser Thr Pro Phe Ala Glu Tyr Thr Asn Ser Val Thr Asn Ile Glu 355 360 365 Leu Glu Pro Pro Phe Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Asp 370 375 380 Ser Ala Leu Thr Leu His Trp Phe Arg Lys Gly Gly Gly Gly Ser Gly 385 390 395 400 Gly Gly Gly Thr Gly Gly Gly Ser Gly Gly Gly Ser Pro Arg Met Lys 405 410 415 Gln Leu Glu Asp Lys Val Glu Glu Leu Leu Ser Lys Asn Tyr His Leu 420 425 430 Glu Asn Glu Val Ala Arg Leu Lys Lys Leu Val Gly Glu Arg Gly Gly 435 440 445 Cys Gly Gly 450 <210> 6 <211> 10705 <212> ARN <213> Secuencia Artificial <220> <223> DENV1 <400> 6 aguuguuagu cuacguggac cgacaagaac aguuucgaau cggaagcuug cuuaacguag 60 uucuaacagu uuuuuauuag agagcagauc ucugaugaac aaccaacgga aaaagacggg 120 ucgaccgucu uucaauaugc ugaaacgcgc gagaaaccgc gugucaacug uuucacaguu 180 ggcgaagaga uucucaaaag gauugcuuuc aggccaagga cccaugaaau uggugauggc 240 uuuuauagca uuccuaagau uucuagccau accuccaaca gcaggaauuu uggcuagaug 300 gggcucauuc aagaagaaug gagcgaucaa aguguuacgg gguuucaaga aagaaaucuc 360 aaacauguug aacauaauga acaggaggaa aagaucugug accaugcucc ucaugcugcu 420 gcccacagcc cuggcguucc aucugaccac ccgaggggga gagccgcaca ugauaguuag 480 caagcaggaa agaggaaaau cacuuuuguu uaagaccucu gcagguguca acaugugcac 540 ccuuauugca auggauuugg gagaguuaug ugaggacaca augaccuaca aaugcccccg 600 gaucacugag acggaaccag augacguuga cuguuggugc aaugccacgg agacaugggu 660 gaccuaugga acauguucuc aaacugguga acaccgacga gacaaacguu ccgucgcacu 720 ggcaccacac guagggcuug gucuagaaac aagaaccgaa acguggaugu ccucugaagg 780 cgcuuggaaa caaauacaaa aaguggagac cugggcucug agacacccag gauucacggu 840 gauagcccuu uuucuagcac augccauagg aacauccauc acccagaaag ggaucauuuu 900 uauuuugcug augcugguaa cuccauccau ggccaugcgg ugcgugggaa uaggcaacag 960 agacuucgug gaaggacugu caggagcuac guggguggau gugguacugg agcauggaag 1020 uugcgucacu accauggcaa aagacaaacc aacacuggac auugaacucu ugaagacgga 1080 ggucacaaac ccugccgucc ugcgcaaacu gugcauugaa gcuaaaauau caaacaccac 1140 caccgauucg agauguccaa cacaaggaga agccacgcug guggaagaac aggacacgaa 1200 cuuugugugu cgacgaacgu ucguggacag aggcuggggc aaugguugug ggcuauucgg 1260 aaaagguagc uuaauaacgu gugcuaaguu uaagugugug acaaaacugg aaggaaagau 1320 aguccaauau gaaaacuuaa aauauucagu gauagucacc guacacacug gagaccagca 1380 ccaaguugga aaugagacca cagaacaugg aacaacugca accauaacac cucaagcucc 1440 cacgucggaa auacagcuga cagacuacgg agcucuaaca uuggauuguu caccuagaac 1500 agggcuagac uuuaaugaga ugguguuguu gacaauggaa aaacgaucgu ggcucgucca 1560 caaacaaugg uuucuagacu uaccacugcc uuggaccucg ggggcuucaa caucccaaga 1620 gacuuggaau agacaagacu ugcuggucac auuuaagaca gcucaugcaa aaaagcagga 1680 aguagucgua cuaggaucac aagaaggagc aaugcacacu gcguugacug gagcgacaga 1740 aauccaaacg ucuggaacga caacaauuuu ugcaggacac cugaaaugca gacuaaaaau 1800 ggauaaacug acuuuaaaag ggaugucaua uguaaugugc acagggucau ucaaguuaga 1860 gaaggaagug gcugagaccc agcauggaac uguucuagug cagguuaaau acgaaggaac 1920 agaugcacca ugcaagaucc ccuucucguc ccaagaugag aagggaguaa cccagaaugg 1980 gagauugaua acagccaacc ccauagucac ugacaaagaa aaaccaguca acauugaagc 2040 ggagccaccu uuuggugaga gcuacauugu gguaggagca ggugaaaaag cuuugaaacu 2100 aagcugguuc aagaagggaa gcaguauagg gaaaauguuu gaagcaacug cccguggagc 2160 acgaaggaug gccauccugg gagacacugc augggacuuc gguucuauag gagggguguu 2220 cacgucugug ggaaaacuga uacaccagau uuuugggacu gcguauggag uuuuguucag 2280 cgguguuucu uggaccauga agauaggaau agggauucug cugacauggc uaggauuaaa 2340 cucaaggagc acgucccuuu caaugacgug uaucgcaguu ggcaugguca cacuguaccu 2400 aggagucaug guucaggcgg acucgggaug uguaaucaac uggaaaggca gagaacucaa 2460 auguggaagc ggcauuuuug ucaccaauga aguccacacc uggacagagc aauauaaauu 2520 ccaggccgac uccccuaaga gacuaucagc ggccauuggg aaggcauggg aggagggugu 2580 guguggaauu cgaucagcca cucgucucga gaacaucaug uggaagcaaa uaucaaauga 2640 auuaaaccac aucuuacuug aaaaugacau gaaauuuaca guggucguag gagacguuag 2700 uggaaucuug gcccaaggaa agaaaaugau uaggccacaa cccauggaac acaaauacuc 2760 guggaaaagc uggggaaaag ccaaaaucau aggagcagau guacagaaua ccaccuucau 2820 caucgacggc ccaaacaccc cagaaugccc ugauaaccaa agagcaugga acauuuggga 2880 aguugaagac uauggauuug gaauuuucac gacaaacaua ugguugaaau ugcgugacuc 2940 cuacacucaa gugugugacc accggcuaau gucagcugcc aucaaggaua gcaaagcagu 3000 ccaugcugac augggguacu ggauagaaag ugaaaagaac gagacuugga aguuggcaag 3060 agccuccuuc auagaaguua agacaugcau cuggccaaaa ucccacacuc uauggagcaa 3120 uggaguccug gaaagugaga ugauaauccc aaagauauau ggaggaccaa uaucucagca 3180 caacuacaga ccaggauauu ucacacaaac agcagggccg uggcacuugg gcaaguuaga 3240 acuagauuuu gauuuaugug aagguaccac uguuguugug gaugaacauu guggaaaucg 3300 aggaccaucu cuuagaacca caacagucac aggaaagaca auccaugaau ggugcuguag 3360 aucuugcacg uuaccccccc uacguuucaa aggagaagac gggugcuggu acggcaugga 3420 aaucagacca gucaaggaga aggaagagaa ccuaguuaag ucaauggucu cugcaggguc 3480 aggagaagug gacaguuuuu cacuaggacu gcuaugcaua ucaauaauga ucgaagaggu 3540 aaugagaucc agauggagca gaaaaaugcu gaugacugga acauuggcug uguuccuccu 3600 ucucacaaug ggacaauuga cauggaauga ucugaucagg cuauguauca ugguuggagc 3660 caacgcuuca gacaagaugg ggaugggaac aacguaccua gcuuugaugg ccacuuucag 3720 aaugagacca auguucgcag ucgggcuacu guuucgcaga uuaacaucua gagaaguucu 3780 ucuucuuaca guuggauuga gucugguggc aucuguagaa cuaccaaauu ccuuagagga 3840 gcuaggggau ggacuugcaa ugggcaucau gauguugaaa uuacugacug auuuucaguc 3900 acaucagcua ugggcuaccu ugcugucuuu aacauuuguc aaaacaacuu uuucauugca 3960 cuaugcaugg aagacaaugg cuaugauacu gucaauugua ucucucuucc cuuuaugccu 4020 guccacgacu ucucaaaaaa caacauggcu uccgguguug cugggaucuc uuggaugcaa 4080 accacuaacc auguuucuua uaacagaaaa caaaaucugg ggaaggaaaa gcuggccucu 4140 caaugaagga auuauggcug uuggaauagu uagcauucuu cuaaguucac uucucaagaa 4200 ugaugugcca cuagcuggcc cacuaauagc uggaggcaug cuaauagcau guuaugucau 4260 aucuggaagc ucggccgauu uaucacugga gaaagcggcu gaggucuccu gggaagaaga 4320 agcagaacac ucuggugccu cacacaacau acuaguggag guccaagaug auggaaccau 4380 gaaaauaaag gaugaagaga gagaugacac acucaccauu cuccucaaag caacucugcu 4440 agcaaucuca gggguauacc caaugucaau accggcgacc cucuuugugu gguauuuuug 4500 gcagaaaaag aaacagagau caggagugcu augggacaca cccagcccuc cagaagugga 4560 aagagcaguc cuugaugaug gcauuuauag aauucuccaa agaggauugu ugggcagguc 4620 ucaaguagga guaggaguuu uucaagaagg cguguuccac acaauguggc acgucaccag 4680 gggagcuguc cucauguacc aagggaagag acuggaacca aguugggcca gugucaaaaa 4740 agacuugauc ucauauggag gagguuggag guuucaagga uccuggaacg cgggagaaga 4800 agugcaggug auugcuguug aaccggggaa gaaccccaaa aauguacaga cagcgccggg 4860 uaccuucaag accccugaag gcgaaguugg agccauagcu cuagacuuua aacccggcac 4920 aucuggaucu ccuaucguga acagagaggg aaaaauagua ggucuuuaug gaaauggagu 4980 ggugacaaca agugguaccu acgucagugc cauagcucaa gcuaaagcau cacaagaagg 5040 gccucuacca gagauugagg acgagguguu uaggaaaaga aacuuaacaa uaauggaccu 5100 acauccagga ucgggaaaaa caagaagaua ccuuccagcc auaguccgug aggccauaaa 5160 aagaaagcug cgcacgcuag ucuuagcucc cacaagaguu gucgcuucug aaauggcaga 5220 ggcgcucaag ggaaugccaa uaagguauca gacaacagca gugaagagug aacacacggg 5280 aaaggagaua guugaccuua ugugucacgc cacuuucacu augcgucucc ugucuccugu 5340 gagaguuccc aauuauaaua ugauuaucau ggaugaagca cauuucaccg auccagccag 5400 cauagcagcc agaggguaua ucucaacccg aguggguaug ggugaagcag cugcgauuuu 5460 caugacagcc acuccccccg gaucggugga ggccuuucca cagagcaaug caguuaucca 5520 agaugaggaa agagacauuc cugaaagauc auggaacuca ggcuaugacu ggaucacuga 5580 uuucccaggu aaaacagucu gguuuguucc aagcaucaaa ucaggaaaug acauugccaa 5640 cuguuuaaga aagaauggga aacggguggu ccaauugagc agaaaaacuu uugacacuga 5700 guaccagaaa acaaaaaaua acgacuggga cuauguuguc acaacagaca uauccgaaau 5760 gggagcaaac uuccgagccg acaggguaau agacccgagg cggugccuga aaccgguaau 5820 acuaaaagau ggcccagagc gugucauucu agccggaccg augccaguga cuguggcuag 5880 cgccgcccag aggagaggaa gaauuggaag gaaccaaaau aaggaaggcg aucaguauau 5940 uuacauggga cagccucuaa aaaaugauga ggaccacgcc cauuggacag aagcaaaaau 6000 gcuccuugac aacauaaaca caccagaagg gauuauccca gcccucuuug agccggagag 6060 agaaaagagu gcagcaauag acggggaaua cagacuacgg ggugaagcga ggaaaacguu 6120 cguggagcuc augagaagag gagaucuacc ugucuggcua uccuacaaag uugccucaga 6180 aggcuuccag uacuccgaca gaagguggug cuuugauggg gaaaggaaca accagguguu 6240 ggaggagaac auggacgugg agaucuggac aaaagaagga gaaagaaaga aacuacgacc 6300 ccgcuggcug gaugccagaa cauacucuga cccacuggcu cugcgcgaau ucaaagaguu 6360 cgcagcagga agaagaagcg ucucagguga ccuaauauua gaaauaggga aacuuccaca 6420 acauuuaacg caaagggccc agaacgccuu ggacaaucug guuauguugc acaacucuga 6480 acaaggagga aaagccuaua gacacgccau ggaagaacua ccagacacca uagaaacguu 6540 aaugcuccua gcuuugauag cugugcugac ugguggagug acguuguucu uccuaucagg 6600 aaggggucua ggaaaaacau 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agagccaccu 10140 gggcgaagaa cauucacacg gccauaaccc aggucaggaa ccugaucgga aaagaggaau 10200 acguggauua caugccagua augaaaagau acagugcucc uucagagagu gaaggaguuc 10260 uguaauuacc aacaacaaac accaaaggcu auugaaguca ggccacuugu gccacgguuu 10320 gagcaaaccg ugcugccugu agcuccgcca auaaugggag gcguaauaau ccccagggag 10380 gccaugcgcc acggaagcug uacgcguggc auauuggacu agcgguuaga ggagaccccu 10440 cccaucacug acaaaacgca gcaaaagggg gcccaagacu agagguuaga ggagaccccc 10500 ccaacacaaa aacagcauau ugacgcuggg aaagaccaga gauccugcug ucucugcaac 10560 aucaauccag gcacagagcg ccgcaagaug gauugguguu guugauccaa cagguucu 10618 <210> 8 <211> 10645 <212> ARN <213> Secuencia Artificial <220> <223> DENV3 <400> 8 aguuguuagu cuacguggac cgacaagaac aguuucgacu cggaagcuug cuuaacguag 60 uacugacagu uuuuuauuag agagcagauc ucugaugaac aaccaacgga aaaagacggg 120 aaaaccgucu aucaauaugc ugaaacgcgu gagaaaccgu gugucaacug gaucacaguu 180 ggcgaagaga uucucaagag gacugcugaa cggccaagga ccaaugaaau ugguuauggc 240 guucauagcu uuccucagau uucuagccau uccaccgaca gcaggagucu uggcuagaug 300 gggaaccuuu aagaagucgg gggcuauuaa gguccugaga ggcuucaaga aggagaucuc 360 aaacaugcug agcauuauca acagacggaa aaagacaucg cucugucuca ugaugauguu 420 accagcaaca cuugcuuucc acuugacuuc acgagaugga gagccgcgca ugauuguggg 480 gaagaaugaa agaggaaaau cccuacuuuu uaagacagcc ucuggaauca acaugugcac 540 acucauagcc auggauuugg gagagaugug ugaugacacg gucaccuaca aaugcccccu 600 cauuacugaa guggagccug aagacauuga cugcuggugc aaccuuacau cgacaugggu 660 gaccuacgga acgugcaauc aagcuggaga gcacagacgc gacaaaagau cgguggcguu 720 agcuccccau gucggcaugg gacuggacac acgcacccaa accuggaugu cggcugaagg 780 agcuuggaga caggucgaga agguagagac augggccuuu aggcacccag gguucacaau 840 acuagcccua uuucuugccc auuacauagg cacuuccuug acccagaaag ugguuauuuu 900 cauacuacua augcugguca ccccauccau gacaaugaga ugcgugggag uaggaaacag 960 agauuuugug gaaggccuau caggagcuac guggguugac guggugcucg agcacggugg 1020 gugugugacu accauggcua agaacaagcc cacgcuggau auagagcucc agaagaccga 1080 ggccacccaa cuggcgaccc uaaggaaacu auguauugag ggaaaaauua ccaacguaac 1140 aaccgacuca aggugcccca cccaagggga agcgauuuua ccugaggagc aggaccagaa 1200 ccacgugugc aagcacacau acguggacag aggcugggga aacgguugug guuuguuugg 1260 caagggaagc cugguaacau gcgcgaaauu ucaauguuug gaaucaauag agggaaaagu 1320 ggugcagcau gagaaccuca aauacaccgu caucaucaca gugcacacag gagaucaaca 1380 ccagguggga aaugaaacgc agggagucac ggcugagaua acaccccagg caucaaccgu 1440 ugaagccauc uuaccugaau auggaacccu ugggcuagaa ugcucaccac ggacagguuu 1500 agauuucaau gaaaugauuu uguugacaau gaagaacaga gcauggaugg uacauagaca 1560 augguuuuuu gaccuaccuu uaccauggac aucaggagcu acaacagaaa caccaaccug 1620 gaauaagaaa gagcuucuug ugacauucaa aaacgcacau gcaaaaaagc aagaaguagu 1680 gguccuugga ucgcaagagg gagcaaugca cacagcacug acaggagcua cagagaucca 1740 aaccucagga ggcacaagua uuuuugcggg gcacuuaaaa uguagacuca agauggacaa 1800 auuggaacuc aaggggauga gcuaugcaau gugcuugaau gccuuugugu ugaagaaaga 1860 agucuccgaa acgcaacaug ggacaauacu caucaagguu gaguacaaag gggaagaugc 1920 accuugcaag auuccuuucu ccacggagga uggacaaggg aaagcccaca auggcagacu 1980 gaucacagcu aacccagugg ugaccaagaa ggaggagccu gucaauauug aggcagaacc 2040 uccuuuuggg gaaagcaaua uaguaauugg aauuggagac aaagccuuga aaauuaacug 2100 guacaagaag ggaagcucga uugggaagau guucgaggcc acugccagag gugcaaggcg 2160 cauggccauc uugggagaca cagccuggga cuuuggauca guagguggug uuuuaaauuc 2220 auuaggaaaa auggugcacc aaauauuugg aagugcuuac acagcccuau uuaguggagu 2280 cuccuggaua augaaaauug gaauaggugu ccuuuuaacc uggauagggu ugaauucaaa 2340 aaacacuagu augagcuuua gcugcauugu gauaggaauc auuacacucu aucugggagc 2400 cguggugcaa gcugacaugg ggugugucau aaacuggaaa ggcaaagaac ucaaaugugg 2460 aaguggaauu uucgucacua augaggucca caccuggaca gagcaauaca aauuucaagc 2520 agacuccccc aaaagacugg cgacagccau ugcaggcgcu ugggagaaug gagugugcgg 2580 aaucaggucg acaaccagaa uggagaaccu cuuguggaag caaauagcca augaacugaa 2640 cuacauauua ugggaaaaca acaucaaauu aacgguaguu gugggugaua uaauuggggu 2700 cuuagagcaa gggaaaagaa cacuaacacc acaacccaug gaacuaaaau auucauggaa 2760 aacaugggga aaggcgaaga uagugacagc ugaaacacaa aauuccucuu ucauaauaga 2820 ugggccaaac acaccagagu guccaagugc cucaagagca uggaaugugu gggaggugga 2880 agauuacggg uucggagucu ucacaacuaa cauauggcug aaacuccgag agauguacac 2940 ccaacuaugu gaccacaggc uaaugucggc agccguuaag gaugagaggg ccguacacgc 3000 cgacaugggc uauuggauag aaagccaaaa gaauggaagu uggaagcuag aaaaggcauc 3060 ccucauagag guaaaaaccu gcacauggcc aaaaucacac acucuuugga gcaauggugu 3120 gcuagagagu gacaugauca ucccaaagag ucuggcuggu cccauuucgc aacacaacua 3180 caggcccgga uaccacaccc aaacggcagg acccuggcac uuaggaaaau uggagcugga 3240 cuucaacuau ugugaaggaa caacaguugu caucacagaa aauuguggga caagaggccc 3300 aucacugaga acaacaacag ugucagggaa guugauacac gaaugguguu gccgcucgug 3360 uacacuuccu ccccugcgau acaugggaga agacggcugc ugguauggca uggaaauuag 3420 acccauuaau gagaaagaag agaacauggu aaagucuuua gucucagcag ggaguggaaa 3480 gguggauaac uucacaaugg gugucuugug uuuggcaauc cuuuuugaag aggugaugag 3540 aggaaaauuu gggaaaaagc acaugauugc agggguucuc uucacguuug uacuccuucu 3600 cucagggcaa auaacaugga gagacauggc gcacacacuc auaaugauug gguccaacgc 3660 cucugacaga augggaaugg gcgucacuua ccuagcauug auugcaacau uuaaaauuca 3720 gccauuuuug gcuuugggau ucuuccugag gaaacugaca ucuagagaaa auuuauuguu 3780 gggaguuggg uuggccaugg caacaacguu acaacugcca gaggacauug aacaaauggc 3840 gaauggaaua gcuuuagggc ucauggcucu uaaauuaaua acacaauuug aaacauacca 3900 acuauggacg gcauuagucu cccuaaugug uucaaauaca auuuucacgu ugacuguugc 3960 cuggagaaca gccacccuga uuuuggccgg aauuucucuu uugccagugu gccagucuuc 4020 gagcaugagg aaaacagauu ggcucccaau ggcuguggca gcuaugggag uuccaccccu 4080 accacuuuuu auuuucaguu ugaaagauac gcucaaaagg agaagcuggc cacugaauga 4140 gggggugaug gcuguuggac uugugaguau ucuagcuagu ucucuccuua ggaaugacgu 4200 gcccauggcu ggaccauuag uggcuggggg cuugcugaua gcgugcuacg ucauaacugg 4260 cacgucagca gaccucacug uagaaaaagc agcagaugug acaugggagg aagaggcuga 4320 gcaaacagga gugucccaca auuuaaugau cacaguugau gacgauggaa caaugagaau 4380 aaaagaugau gagacugaga acaucuuaac agugcuuuug aaaacagcau uacuaauagu 4440 gucaggcauu uuuccauacu ccauacccgc aacacuguug gucuggcaca cuuggcaaaa 4500 gcaaacccaa agauccggug uccuauggga cguucccagc cccccagaga cacagaaagc 4560 agaacuggaa gaagggguuu auaggaucaa gcagcaagga auuuuuggga aaacccaagu 4620 ggggguugga guacaaaaag aaggaguuuu ccacaccaug uggcacguca caagaggagc 4680 aguguugaca cacaauggga aaagacugga accaaacugg gcuagcguga aaaaagaucu 4740 gauuucauac ggaggaggau ggaaauugag ugcacaaugg caaaaaggag aggaggugca 4800 gguuauugcc guagagccug ggaagaaccc aaagaacuuu caaaccaugc caggcauuuu 4860 ccagacaaca acaggggaga uaggagcgau ugcacuggac uucaagccug gaacuucagg 4920 aucucccauc auaaacagag agggaaaggu acugggauug uauggcaaug gaguggucac 4980 aaagaauggu ggcuauguca guggaauagc acaaacaaau gcagaaccag acggaccgac 5040 accagaguug gaagaagaga uguucaaaaa gcgaaaucua accauaaugg aucuccaucc 5100 cgggucagga aagacgcgga aauaucuucc agcuauuguu agagaggcaa ucaagagacg 5160 cuuaaggacu cuaauuuugg caccaacaag gguaguugca gcugagaugg aagaagcauu 5220 gaaagggcuc ccaauaaggu aucaaacaac ugcaacaaaa ucugaacaca cagggagaga 5280 gauuguugau cuaaugugcc acgcaacguu cacaaugcgu uugcugucac cagucagggu 5340 uccaaacuac aacuugauaa uaauggauga ggcucauuuc acagacccag ccaguauagc 5400 ggcuagaggg uacauaucaa cucguguagg aaugggagag gcagccgcaa uuuucaugac 5460 agccacaccc ccuggaacag cugaugccuu uccucagagc aacgcuccaa uucaagauga 5520 agaaagagac auaccagaac gcucauggaa uucaggcaau gaauggauua ccgacuuugc 5580 cgggaagacg gugugguuug ucccuagcau caaagcugga aaugacauag caaacugcuu 5640 gcggaaaaau ggaaaaaagg ucauucaacu uaguaggaag acuuuugaca cagaauauca 5700 aaagacuaaa cuaaaugauu gggacuuugu ggugacaaca gacauuucag aaaugggagc 5760 caauuucaaa gcagacagag ugaucgaccc aagaagaugu cucaagccag ugauuuugac 5820 agacggaccc gagcgcguga uccuggcggg accaaugcca gucaccguag cgagcgcugc 5880 gcaaaggaga gggagaguug gcaggaaccc acaaaaagaa aaugaccaau acauauucau 5940 gggccagccc cucaauaaug augaagacca ugcucacugg acagaagcaa aaaugcugcu 6000 agacaacauc aacacaccag aagggaucau accagcucuc uuugaaccag aaagggagaa 6060 gucagccgcc auagacggcg aauaccgccu gaagggugag uccaggaaga ccuucgugga 6120 acucaugagg aggggugacc ucccaguuug gcuagcccau aaaguagcau cagaagggau 6180 caaauauaca gauagaaagu gguguuuuga uggagaacgc aacaaucaaa uuuuagagga 6240 gaauauggau guggaaaucu ggacaaagga aggagaaaag aaaaaauuga gaccuaggug 6300 gcuugaugcc cgcacuuauu cagaucccuu agcgcucaag gaauucaagg acuuugcggc 6360 ugguagaaag ucaauugccc uugaucuugu gacagaaaua ggaagagugc cuucacacuu 6420 agcucacaga acgagaaacg cccuggacaa ucuggugaug uugcacacgu cagaacaugg 6480 cgggagggcc uacaggcaug caguggagga acuaccagaa acaauggaaa cacucuuacu 6540 ccugggacuc augauccugu uaacaggugg agcaaugcuu uucuugauau cagguaaagg 6600 gauuggaaag acuucaauag gacucauuug uguagcugcu uccagcggua uguuauggau 6660 ggcugauguc ccacuccaau ggaucgcguc ugccauaguc cuggaguuuu uuaugauggu 6720 guuacuuaua ccagaaccag aaaagcagag aacuccccaa gacaaucaac ucgcauaugu 6780 cgugauaggc auacucacac uggcugcaau aguagcagcc aaugaaaugg gacuguugga 6840 aaccacaaag agagauuuag gaauguccaa agaaccaggu guuguuucuc caaccagcua 6900 uuuggaugug gacuugcacc cagcaucagc cuggacauug uacgcugugg ccacaacagu 6960 aauaacacca auguugagac auaccauaga gaauuccaca gcaaaugugu cccuggcagc 7020 uauagccaac caggcagugg uccugauggg uuuagacaaa ggauggccga uaucgaaaau 7080 ggacuuaggc gugccacuau uggcacuggg uuguuauuca caagugaacc cacuaacucu 7140 cacagcggca guucuccugc uagccacgca uuaugcuauu auagguccag gauugcaggc 7200 aaaagccacu cgugaagcuc aaaaaaggac agcugcugga auaaugaaga auccaacggu 7260 ggaugggaua augacaauag accuagaucc uguaauauac gauccaaaau uugaaaagca 7320 acuaggacag guuaugcucc ugguucugug ugcaguucaa cuuuuguuaa ugagaacauc 7380 augggcuuuu ugugaagcuc uaacccuagc cacaggacca auaacaacac ucugggaagg 7440 aucaccuggg aaguucugga acaccacgau agcuguuucc auggcgaaca ucuuuagagg 7500 gagcuauuua gcaggagcug ggcuugcuuu uucuaucaug aaaucaguug gaacaggaaa 7560 gagagggaca gggucacagg gugaaaccuu gggagaaaag uggaaaaaga aauugaauca 7620 auuaccccgg aaagaguuug accuuuacaa gaaauccgga aucacugaag uggauagaac 7680 agaagccaaa gaaggguuga aaagaggaga aauaacacac caugccgugu ccagaggcag 7740 cgcaaaacuu caaugguucg uggagagaaa cauggucauc cccgaaggaa gagucauaga 7800 cuuaggcugu ggaagaggag gcuggucaua uuauugugca ggacugaaaa aaguuacaga 7860 agugcgagga uacacaaaag gcggcccagg acaugaagaa ccaguaccua ugucuacaua 7920 cggauggaac auagucaagu uaaugagugg aaaggaugug uuuuaucuuc caccugaaaa 7980 gugugauacu cuauugugug acauuggaga aucuucacca agcccaacag uggaagaaag 8040 cagaaccaua agagucuuga agaugguuga accauggcua agaaauaacc aguuuugcau 8100 uaaaguauug aacccuuaca ugccaacugu gauugagcac cuagaaagac uacaaaggaa 8160 acauggagga augcuuguga gaaauccacu cucacgaaac uccacgcacg aaauguacug 8220 gauaucuaau ggcacaggca auaucguuuc uucagucaac augguaucca gauugcuacu 8280 uaacagauuc acaaugacac auaggagacc caccauagag aaagaugugg auuuaggagc 8340 ggggacccga caugucaaug cggaaccaga aacacccaac auggauguca uuggggaaag 8400 aauaagaagg aucaaggagg agcauaguuc aacauggcac uaugaugaug aaaauccuua 8460 uaaaacgugg gcuuaccaug gauccuauga aguuaaggcc acaggcucag ccuccuccau 8520 gauaaaugga gucgugaaac uccucacgaa accaugggau guggugccca uggugacaca 8580 gauggcaaug acggauacaa ccccauucgg ccagcaaagg guuuuuaaag agaaagugga 8640 caccaggaca cccagaccua ugccaggaac aagaaagguu auggagauca cagcggaaug 8700 gcuuuggaga acccugggaa ggaacaaaag acccagauua uguacgagag aggaguucac 8760 aaaaaagguc agaaccaacg cagcuauggg cgccguuuuu acagaggaga accaauggga 8820 cagugcuaga gcugcuguug aggaugaaga auucuggaaa cucguggaca gagaacguga 8880 acuccacaaa uugggcaagu guggaagcug cguuuacaac augaugggca agagagagaa 8940 gaaacuugga gaguuuggca aagcaaaagg caguagagcc auaugguaca ugugguuggg 9000 agccagauac cuugaguucg aagcacucgg auucuuaaau gaagaccauu gguucucgcg 9060 ugaaaacucu uacaguggag uagaaggaga aggacugcac aagcugggau acaucuuaag 9120 agacauuucc aagauacccg gaggagcuau guaugcugau gacacagcug guugggacac 9180 aagaauaaca gaagaugacc ugcacaauga ggaaaaaauc acacagcaaa uggacccuga 9240 acacaggcag uuagcaaacg cuauauucaa gcucacauac caaaacaaag uggucaaagu 9300 ucaacgacca acuccaaagg gcacgguaau ggacaucaua ucuaggaaag accaaagagg 9360 caguggacag gugggaacuu auggucugaa uacauucacc aacauggaag cccaguuaau 9420 cagacaaaug gaaggagaag guguguuguc gaaggcagac cucgagaacc cucaucugcu 9480 agagaagaaa guuacacaau gguuggaaac aaaaggagug gagagguuaa aaagaauggc 9540 caucagcggg gaugauugcg uggugaaacc aauugaugac agguucgcca augcccugcu 9600 ugcccugaau gacaugggaa aaguuaggaa ggacauaccu caauggcagc caucaaaggg 9660 auggcaugau uggcaacagg ucccuuucug cucccaccac uuucaugaau ugaucaugaa 9720 agauggaaga aaguugguag uucccugcag accucaggau gaauuaaucg ggagagcgag 9780 aaucucucaa ggagcaggau ggagccuuag agaaacugca ugccuaggga aagccuacgc 9840 ccaaaugugg acucucaugu acuuucacag aagagaucuu agacuagcau ccaacgccau 9900 auguucagca guaccagucc auuggguccc cacaagcaga acgacguggu cuauucaugc 9960 ucaccaucag uggaugacua cagaagacau gcuuacuguu uggaacaggg uguggauaga 10020 ggauaaucca uggauggaag acaaaacucc agucaaaacc ugggaagaug uuccauaucu 10080 agggaagaga gaagaccaau ggugcggauc acucauuggu cucacuucca gagcaaccug 10140 ggcccagaac auacuuacgg caauccaaca ggugagaagc cuuauaggca augaagaguu 10200 ucuggacuac augccuucga ugaagagauu caggaaggag gaggagucag agggagccau 10260 uugguaaacg uaggaaguga aaaagaggca aacugucagg ccaccuuaag ccacaguacg 10320 gaagaagcug ugcagccugu gagccccguc caaggacguu aaaagaagaa 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