LISTADO DE SECUENCIAS <110> BRISTOL-MYERS SQUIBB COMPANY ROCHE INNOVATION CENTER COPENHAGEN A/S <120> OLIGONUCLEÓTIDOS ANTISENTIDO QUE ACTÚAN SOBRE ALFA-SINUCLEÍNA, Y USOS DE ESTOS <130> 3338.107PC01/ELE/C-K/DKC <150> 62/616,937 <151> 2018-01-12 <160> 10 <170> PatentIn versión 3.5 <210> 1 <211> 2400 <212> ADN <213> Homo sapiens <400> 1 gagataggga cgaggagcac gctgcaggga aagcagcgag cgccgggaga ggggcgggca 60 gaagcgctga caaatcagcg gtgggggcgg agagccgagg agaaggagaa ggaggaggac 120 taggaggagg aggacggcga cgaccagaag gggcccaaga gagggggcga gcgaccgagc 180 gccgcgacgc ggaagtgagg tgcgtgcggg ctgcagcgca gaccccggcc cggcccctcc 240 gagagcgtcc tgggcgctcc ctcacgcctt gccttcaagc cttctgcctt tccaccctcg 300 tgagcggaga actgggagtg gccattcgac gacaggttag cgggtttgcc tcccactccc 360 ccagcctcgc gtcgccggct cacagcggcc tcctctgggg acagtccccc ccgggtgccg 420 cctccgccct tcctgtgcgc tccttttcct tcttctttcc tattaaatat tatttgggaa 480 ttgtttaaat ttttttttta aaaaaagaga gaggcgggga ggagtcggag ttgtggagaa 540 gcagagggac tcaggtaagt acctgtggat ctaaacgggc gtctttggaa atcctggaga 600 acgccggatg ggagacgaat ggtcgtgggc accgggaggg ggtggtgctg ccatgaggac 660 ccgctgggcc aggtctctgg gaggtgagta cttgtccctt tggggagcct aaggaaagag 720 acttgacctg gctttcgtcc tgcttctgat attcccttct ccacaagggc tgagagatta 780 ggctgcttct ccgggatccg cttttccccg ggaaacgcga ggatgctcca tggagcgtga 840 gcatccaact tttctctcac ataaaatctg tctgcccgct ctcttggttt ttctctgtaa 900 agtaagcaag ctgcgtttgg caaataatga aatggaagtg caaggaggcc aagtcaacag 960 gtggtaacgg gttaacaagt gctggcgcgg ggtccgctag ggtggaggct gagaacgccc 1020 cctcgggtgg ctggcgcggg gttggagacg gcccgcgagt gtgagcggcg cctgctcagg 1080 gtagatagct gagggcgggg gtggatgttg gatggattag aaccatcaca cttgggcctg 1140 ctgtttgcct gagtttgaac cacaccccga gtgagcagtt agttctgttg cctacgcctt 1200 tccaccatca acctgttagc cttcttctgg gattcatgtt aaggataccc ctgaccctaa 1260 gcctccagct tccatgcttc taactcatac tgttaccctt tagaccccgg gaatttaaaa 1320 aaggggttaa tcttttcatg caactccact tctgaaatgc agtaataaca actcagagga 1380 ttcatcctaa tccgtggtta ggtggctaga cttttactag ccaagatgga tgggagatgc 1440 taaattttta atgccagagc taaaaatgtc tgctttgtcc aatggttaaa tgagtgtaca 1500 cttaaaagag tctcacactt tggagggttt ctcatgattt ttcagtgttt tttgtttatt 1560 tttccccgaa agttctcatt caaagtgtat tttatgtttt ccagtgtggt gtaaaggaat 1620 tcattagcca tggatgtatt catgaaagga ctttcaaagg ccaaggaggg agttgtggct 1680 gctgctgaga aaaccaaaca gggtgtggca gaagcagcag gaaagacaaa agagggtgtt 1740 ctctatgtag gtaggtaaac cccaaatgtc agtttggtgc ttgttcatga gtgatgggtt 1800 aggataatca atactctaaa tgctggtagt tctctctctt gattcatttt tgcatcattg 1860 cttgtcaaaa aggtggactg agtcagaggt atgtgtaggt aggtgaatgt gaacgtgtgt 1920 atttgagcta atagtaaaaa atgcgactgt ttgcttttcc agatttttaa ttttgcccta 1980 atatttatga ctttttaaaa atgaatgttt ctgtacctac ataattctat ttcagagaac 2040 agttttaaaa actcatagtc ttttaaaaaa taatcaagaa tattcttaag aatcaaaatc 2100 attgatggat ctgtgatttc ttttaccatc atgaaaaatg tttgtcaatt ttaatccatt 2160 ctgattttta aaatatgact ttgatatgcc cctgtgatgt gtataaagag acctatttgt 2220 ggccctaaaa tggaaagaac agattagtct ttgatagagt tacttcatgt gatcatttgg 2280 tctctgtgaa cactgaggac agagaaaagt gcttgagggc tgctactaat ctctcagaaa 2340 catttgtata gttcatccat caaatgacac acatactaaa agaataaaga aattgatgct 2400 <210> 2 <211> 3215 <212> ADN <213> Homo sapiens <400> 2 aggagaagga gaaggaggag gactaggagg aggaggacgg cgacgaccag aaggggccca 60 agagaggggg cgagcgaccg agcgccgcga cgcggaagtg aggtgcgtgc gggctgcagc 120 gcagaccccg gcccggcccc tccgagagcg tcctgggcgc tccctcacgc cttgccttca 180 agccttctgc ctttccaccc tcgtgagcgg agaactggga gtggccattc gacgacagtg 240 tggtgtaaag gaattcatta gccatggatg tattcatgaa aggactttca aaggccaagg 300 agggagttgt ggctgctgct gagaaaacca aacagggtgt ggcagaagca gcaggaaaga 360 caaaagaggg tgttctctat gtaggctcca aaaccaagga gggagtggtg catggtgtgg 420 caacagtggc tgagaagacc aaagagcaag tgacaaatgt tggaggagca gtggtgacgg 480 gtgtgacagc agtagcccag aagacagtgg agggagcagg gagcattgca gcagccactg 540 gctttgtcaa aaaggaccag ttgggcaaga atgaagaagg agccccacag gaaggaattc 600 tggaagatat gcctgtggat cctgacaatg aggcttatga aatgccttct gaggaagggt 660 atcaagacta cgaacctgaa gcctaagaaa tatctttgct cccagtttct tgagatctgc 720 tgacagatgt tccatcctgt acaagtgctc agttccaatg tgcccagtca tgacatttct 780 caaagttttt acagtgtatc tcgaagtctt ccatcagcag tgattgaagt atctgtacct 840 gcccccactc agcatttcgg tgcttccctt tcactgaagt gaatacatgg tagcagggtc 900 tttgtgtgct gtggattttg tggcttcaat ctacgatgtt aaaacaaatt aaaaacacct 960 aagtgactac cacttatttc taaatcctca ctattttttt gttgctgttg ttcagaagtt 1020 gttagtgatt tgctatcata tattataaga tttttaggtg tcttttaatg atactgtcta 1080 agaataatga cgtattgtga aatttgttaa tatatataat acttaaaaat atgtgagcat 1140 gaaactatgc acctataaat actaaatatg aaattttacc attttgcgat gtgttttatt 1200 cacttgtgtt tgtatataaa tggtgagaat taaaataaaa cgttatctca ttgcaaaaat 1260 attttatttt tatcccatct cactttaata ataaaaatca tgcttataag caacatgaat 1320 taagaactga cacaaaggac aaaaatataa agttattaat agccatttga agaaggagga 1380 attttagaag aggtagagaa aatggaacat taaccctaca ctcggaattc cctgaagcaa 1440 cactgccaga agtgtgtttt ggtatgcact ggttccttaa gtggctgtga ttaattattg 1500 aaagtggggt gttgaagacc ccaactacta ttgtagagtg gtctatttct cccttcaatc 1560 ctgtcaatgt ttgctttacg tattttgggg aactgttgtt tgatgtgtat gtgtttataa 1620 ttgttataca tttttaattg agccttttat taacatatat tgttattttt gtctcgaaat 1680 aattttttag ttaaaatcta ttttgtctga tattggtgtg aatgctgtac ctttctgaca 1740 ataaataata ttcgaccatg aataaaaaaa aaaaaaaagt gggttcccgg gaactaagca 1800 gtgtagaaga tgattttgac tacaccctcc ttagagagcc ataagacaca ttagcacata 1860 ttagcacatt caaggctctg agagaatgtg gttaactttg tttaactcag cattcctcac 1920 tttttttttt taatcatcag aaattctctc tctctctctc tctttttctc tcgctctctt 1980 tttttttttt tttttacagg aaatgccttt aaacatcgtt ggaactacca gagtcacctt 2040 aaaggagatc aattctctag actgataaaa atttcatggc ctcctttaaa tgttgccaaa 2100 tatatgaatt ctaggatttt tccttaggaa aggtttttct ctttcaggga agatctatta 2160 actccccatg ggtgctgaaa ataaacttga tggtgaaaaa ctctgtataa attaatttaa 2220 aaattatttg gtttctcttt ttaattattc tggggcatag tcatttctaa aagtcactag 2280 tagaaagtat aatttcaaga cagaatattc tagacatgct agcagtttat atgtattcat 2340 gagtaatgtg atatatattg ggcgctggtg aggaaggaag gaggaatgag tgactataag 2400 gatggttacc atagaaactt ccttttttac ctaattgaag agagactact acagagtgct 2460 aagctgcatg tgtcatctta cactagagag aaatggtaag tttcttgttt tatttaagtt 2520 atgtttaagc aaggaaagga tttgttattg aacagtatat ttcaggaagg ttagaaagtg 2580 gcggttagga tatattttaa atctacctaa agcagcatat tttaaaaatt taaaagtatt 2640 ggtattaaat taagaaatag aggacagaac tagactgata gcagtgacct agaacaattt 2700 gagattagga aagttgtgac catgaattta aggatttatg tggatacaaa ttctccttta 2760 aagtgtttct tcccttaata tttatctgac ggtaattttt gagcagtgaa ttactttata 2820 tatcttaata gtttatttgg gaccaaacac ttaaacaaaa agttctttaa gtcatataag 2880 ccttttcagg aagcttgtct catattcact cccgagacat tcacctgcca agtggcctga 2940 ggatcaatcc agtcctaggt ttattttgca gacttacatt ctcccaagtt attcagcctc 3000 atatgactcc acggtcggct ttaccaaaac agttcagagt gcactttggc acacaattgg 3060 gaacagaaca atctaatgtg tggtttggta ttccaagtgg ggtctttttc agaatctctg 3120 cactagtgtg agatgcaaac atgtttcctc atctttctgg cttatccagt atgtagctat 3180 ttgtgacata ataaatatat acatatatga aaata 3215 <210> 3 <211> 140 <212> PRT <213> Homo sapiens <400> 3 Met Asp Val Phe Met Lys Gly Leu Ser Lys Ala Lys Glu Gly Val Val 1 5 10 15 Ala Ala Ala Glu Lys Thr Lys Gln Gly Val Ala Glu Ala Ala Gly Lys 20 25 30 Thr Lys Glu Gly Val Leu Tyr Val Gly Ser Lys Thr Lys Glu Gly Val 35 40 45 Val His Gly Val Ala Thr Val Ala Glu Lys Thr Lys Glu Gln Val Thr 50 55 60 Asn Val Gly Gly Ala Val Val Thr Gly Val Thr Ala Val Ala Gln Lys 65 70 75 80 Thr Val Glu Gly Ala Gly Ser Ile Ala Ala Ala Thr Gly Phe Val Lys 85 90 95 Lys Asp Gln Leu Gly Lys Asn Glu Glu Gly Ala Pro Gln Glu Gly Ile 100 105 110 Leu Glu Asp Met Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu Met Pro 115 120 125 Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu Ala 130 135 140 <210> 4 <211> 17 <212> ADN <213> Secuencia artificial <220> <223> Oligonucleótidos antisentido <400> 4 attcctttac accacac 17 <210> 5 <211> 15 <212> ADN <213> Secuencia artificial <220> <223> Oligonucleótidos antisentido <400> 5 tctgtcttgg ctttg 15 <210> 6 <211> 16 <212> ADN <213> Secuencia artificial <220> <223> Oligonucleótidos antisentido <400> 6 agaaataagt ggtagt 16 <210> 7 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Oligonucleótidos antisentido <400> 7 ccaaatctta taataactac 20 <210> 8 <211> 16 <212> ADN <213> Secuencia artificial <220> <223> Oligonucleótidos antisentido <400> 8 ttcctttaca ccacac 16 <210> 9 <211> 16 <212> ADN <213> Secuencia artificial <220> <223> Oligonucleótidos antisentido <400> 9 ggtgaggttt ggtaga 16 <210> 10 <211> 18 <212> ADN <213> Secuencia artificial <220> <223> Oligonucleótidos antisentido <400> 10 ggtgaggttt ggtagaag 18