LISTADO DE SECUENCIAS <110> ALECTOR LLC <120> ANTICUERPOS ANTI-SIRPA Y MÉTODOS DE USO DE LOS MISMOS <130> 40004-PCT <140> <141> <150> 62/676.813 <151> 25-05-2018 <160> 70 <170> PatentIn versión 3.5 <210> 1 <211> 504 <212> PRT <213> Homo sapiens <400> 1 Met Glu Pro Ala Gly Pro Ala Pro Gly Arg Leu Gly Pro Leu Leu Cys 1 5 10 15 Leu Leu Leu Ala Ala Ser Cys Ala Trp Ser Gly Val Ala Gly Glu Glu 20 25 30 Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala Ala Gly 35 40 45 Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro Val Gly 50 55 60 Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu Ile Tyr 65 70 75 80 Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Asp Leu 85 90 95 Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn Ile Thr 100 105 110 Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser 115 120 125 Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val 130 135 140 Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala 145 150 155 160 Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser 165 170 175 Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser 180 185 190 Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser Tyr Ser 195 200 205 Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser 210 215 220 Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu 225 230 235 240 Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro Thr Leu 245 250 255 Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val Thr 260 265 270 Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu 275 280 285 Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val Thr Glu 290 295 300 Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Val 305 310 315 320 Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His Asp 325 330 335 Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Ala His 340 345 350 Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly Ser Asn 355 360 365 Glu Arg Asn Ile Tyr Ile Val Val Gly Val Val Cys Thr Leu Leu Val 370 375 380 Ala Leu Leu Met Ala Ala Leu Tyr Leu Val Arg Ile Arg Gln Lys Lys 385 390 395 400 Ala Gln Gly Ser Thr Ser Ser Thr Arg Leu His Glu Pro Glu Lys Asn 405 410 415 Ala Arg Glu Ile Thr Gln Asp Thr Asn Asp Ile Thr Tyr Ala Asp Leu 420 425 430 Asn Leu Pro Lys Gly Lys Lys Pro Ala Pro Gln Ala Ala Glu Pro Asn 435 440 445 Asn His Thr Glu Tyr Ala Ser Ile Gln Thr Ser Pro Gln Pro Ala Ser 450 455 460 Glu Asp Thr Leu Thr Tyr Ala Asp Leu Asp Met Val His Leu Asn Arg 465 470 475 480 Thr Pro Lys Gln Pro Ala Pro Lys Pro Glu Pro Ser Phe Ser Glu Tyr 485 490 495 Ala Ser Val Gln Val Pro Arg Lys 500 <210> 2 <211> 122 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 2 Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 1 5 10 15 Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 35 40 45 Ala Thr Ile Ser Asp Tyr Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser 50 55 60 Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Tyr Thr Leu 65 70 75 80 Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr 85 90 95 Cys Ala Arg Pro Pro Tyr Asp Asp Tyr Tyr Gly Gly Phe Ala Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ala 115 120 <210> 3 <211> 122 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 3 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Ser Asp Tyr Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser 50 55 60 Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 65 70 75 80 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Lys Pro Pro Tyr Asp Asp Tyr Tyr Gly Gly Phe Ala Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 4 <211> 122 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 4 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Thr Ile Ser Asp Tyr Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser 50 55 60 Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 65 70 75 80 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Pro Pro Tyr Asp Asp Tyr Tyr Gly Gly Phe Ala Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 5 <211> 111 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 5 Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Ser Ser 20 25 30 Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 35 40 45 Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 65 70 75 80 Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Asn Arg 85 90 95 Glu Leu Pro Cys Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 6 <211> 111 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 6 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Ser Ser 20 25 30 Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 35 40 45 Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 65 70 75 80 Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Asn Arg 85 90 95 Glu Leu Pro Cys Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 7 <211> 111 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 7 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Ser Ser 20 25 30 Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 35 40 45 Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 65 70 75 80 Ser Val Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Asn Arg 85 90 95 Glu Leu Pro Cys Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 8 <211> 111 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 8 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Val Gly 1 5 10 15 Asp Arg Ala Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Ser Ser 20 25 30 Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 35 40 45 Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 65 70 75 80 Ser Val Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Asn Arg 85 90 95 Glu Leu Pro Cys Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 9 <211> 15 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 9 Arg Ala Ser Lys Ser Val Ser Ser Gly Gly Tyr Ser Tyr Met His 1 5 10 15 <210> 10 <211> 7 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 10 Leu Ala Ser Asn Leu Glu Ser 1 5 <210> 11 <211> 9 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 11 Gln His Asn Arg Glu Leu Pro Ser Thr 1 5 <210> 12 <211> 9 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 12 Gln His Asn Arg Glu Leu Pro Cys Thr 1 5 <210> 13 <211> 9 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 13 Gln His Asn Arg Glu Leu Pro Ile Thr 1 5 <210> 14 <211> 9 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 14 Gln His Asn Arg Glu Leu Pro Pro Thr 1 5 <210> 15 <211> 9 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 15 Gln His Asn Arg Glu Leu Pro Thr Thr 1 5 <210> 16 <211> 9 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 16 Gln His Asn Arg Glu Leu Pro Val Thr 1 5 <210> 17 <211> 9 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 17 Gln His Asn Arg Glu Leu Pro Ala Thr 1 5 <210> 18 <211> 9 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 18 Gln His Asn Arg Glu Leu Pro Gly Thr 1 5 <210> 19 <211> 9 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 19 Gln His Asn Arg Glu Leu Pro Trp Thr 1 5 <210> 20 <211> 10 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 20 Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser 1 5 10 <210> 21 <211> 18 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 21 Thr Ile Ser Glu Tyr Gly Gly Ser Tyr Thr Tyr Tyr Ala Glu Ser Val 1 5 10 15 Lys Gly <210> 22 <211> 12 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 22 Pro Pro Tyr Asp Asp Tyr Tyr Gly Gly Phe Ala Tyr 1 5 10 <210> 23 <211> 12 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 23 Pro Pro Tyr Asp Asp Tyr Tyr Gly Gly Phe Arg Tyr 1 5 10 <210> 24 <211> 12 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 24 Pro Pro Tyr Asp Asp Tyr Tyr Gly Gly Phe Gln Tyr 1 5 10 <210> 25 <211> 25 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 25 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser 20 25 <210> 26 <211> 14 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 26 Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 1 5 10 <210> 27 <211> 32 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 27 Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 1 5 10 15 Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 20 25 30 <210> 28 <211> 11 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 28 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 1 5 10 <210> 29 <211> 23 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 29 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys 20 <210> 30 <211> 15 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 30 Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 1 5 10 15 <210> 31 <211> 32 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 31 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 1 5 10 15 Leu Thr Ile Ser Ser Val Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 20 25 30 <210> 32 <211> 10 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 32 Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 1 5 10 <210> 33 <211> 122 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 33 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Thr Ile Ser Glu Tyr Gly Gly Ser Tyr Thr Tyr Tyr Ala Glu Ser 50 55 60 Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 65 70 75 80 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Pro Pro Tyr Asp Asp Tyr Tyr Gly Gly Phe Ala Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 34 <211> 122 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 34 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Thr Ile Ser Glu Tyr Gly Gly Ser Tyr Thr Tyr Tyr Ala Glu Ser 50 55 60 Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 65 70 75 80 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Pro Pro Tyr Asp Asp Tyr Tyr Gly Gly Phe Arg Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 35 <211> 122 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 35 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Thr Ile Ser Glu Tyr Gly Gly Ser Tyr Thr Tyr Tyr Ala Glu Ser 50 55 60 Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 65 70 75 80 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Pro Pro Tyr Asp Asp Tyr Tyr Gly Gly Phe Gln Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 36 <211> 111 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 36 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Ser Gly 20 25 30 Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 35 40 45 Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 65 70 75 80 Ser Val Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Asn Arg 85 90 95 Glu Leu Pro Ser Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 37 <211> 111 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 37 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Ser Gly 20 25 30 Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 35 40 45 Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 65 70 75 80 Ser Val Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Asn Arg 85 90 95 Glu Leu Pro Cys Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 38 <211> 111 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 38 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Ser Gly 20 25 30 Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 35 40 45 Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 65 70 75 80 Ser Val Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Asn Arg 85 90 95 Glu Leu Pro Ile Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 39 <211> 111 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 39 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Ser Gly 20 25 30 Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 35 40 45 Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 65 70 75 80 Ser Val Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Asn Arg 85 90 95 Glu Leu Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 40 <211> 111 <212> PRT <213> Secueencia Artificial <220> <221> fuente <223> //nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 40 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Ser Gly 20 25 30 Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 35 40 45 Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 65 70 75 80 Ser Val Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Asn Arg 85 90 95 Glu Leu Pro Thr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 41 <211> 111 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 41 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Ser Gly 20 25 30 Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 35 40 45 Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 65 70 75 80 Ser Val Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Asn Arg 85 90 95 Glu Leu Pro Val Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 42 <211> 111 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 42 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Ser Gly 20 25 30 Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 35 40 45 Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 65 70 75 80 Ser Val Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Asn Arg 85 90 95 Glu Leu Pro Ala Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 43 <211> 111 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 43 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Ser Gly 20 25 30 Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 35 40 45 Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 65 70 75 80 Ser Val Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Asn Arg 85 90 95 Glu Leu Pro Gly Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 44 <211> 111 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 44 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Ser Gly 20 25 30 Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 35 40 45 Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 65 70 75 80 Ser Val Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Asn Arg 85 90 95 Glu Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 45 <211> 118 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 45 Glu Phe Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Leu Thr Gly Tyr 20 25 30 Asn Met Asn Trp Val Lys Gln Ser Arg Gly Lys Ser Leu Glu Trp Ile 35 40 45 Gly Asn Ile Asn Pro His Tyr Gly Ser Ser Thr Tyr Asn Gln Asn Phe 50 55 60 Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Ala Ala Tyr 65 70 75 80 Met Gln Phe Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Gly Tyr Asp Gly Val Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Thr Leu Thr Val Ser Ser 115 <210> 46 <211> 106 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 46 Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 1 5 10 15 Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 35 40 45 Val Thr Ser Asn Leu Ala Ser Gly Val Pro Thr Arg Phe Ser Gly Ser 50 55 60 Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 65 70 75 80 Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Arg Thr 85 90 95 Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 47 <211> 452 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 47 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Thr Ile Ser Glu Tyr Gly Gly Ser Tyr Thr Tyr Tyr Ala Glu Ser 50 55 60 Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 65 70 75 80 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Pro Pro Tyr Asp Asp Tyr Tyr Gly Gly Phe Gln Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 115 120 125 Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 130 135 140 Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 145 150 155 160 Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 165 170 175 Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 180 185 190 Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 195 200 205 His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 210 215 220 Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 225 230 235 240 Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 245 250 255 Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 260 265 270 His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 275 280 285 Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 290 295 300 Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 305 310 315 320 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 325 330 335 Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 340 345 350 Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 355 360 365 Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 370 375 380 Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 385 390 395 400 Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 405 410 415 Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 420 425 430 Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 435 440 445 Ser Pro Gly Lys 450 <210> 48 <211> 452 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 48 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Thr Ile Ser Glu Tyr Gly Gly Ser Tyr Thr Tyr Tyr Ala Glu Ser 50 55 60 Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 65 70 75 80 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Pro Pro Tyr Asp Asp Tyr Tyr Gly Gly Phe Gln Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 115 120 125 Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 130 135 140 Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 145 150 155 160 Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 165 170 175 Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 180 185 190 Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 195 200 205 His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 210 215 220 Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 225 230 235 240 Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 245 250 255 Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 260 265 270 His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 275 280 285 Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 290 295 300 Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 305 310 315 320 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser 325 330 335 Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 340 345 350 Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 355 360 365 Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 370 375 380 Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 385 390 395 400 Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 405 410 415 Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 420 425 430 Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 435 440 445 Ser Pro Gly Lys 450 <210> 49 <211> 452 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 49 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Thr Ile Ser Glu Tyr Gly Gly Ser Tyr Thr Tyr Tyr Ala Glu Ser 50 55 60 Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 65 70 75 80 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Pro Pro Tyr Asp Asp Tyr Tyr Gly Gly Phe Gln Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 115 120 125 Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 130 135 140 Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 145 150 155 160 Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 165 170 175 Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 180 185 190 Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 195 200 205 His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 210 215 220 Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 225 230 235 240 Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 245 250 255 Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Glu 260 265 270 His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 275 280 285 Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 290 295 300 Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 305 310 315 320 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Phe Pro Ala Pro 325 330 335 Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 340 345 350 Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 355 360 365 Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 370 375 380 Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 385 390 395 400 Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 405 410 415 Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 420 425 430 Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 435 440 445 Ser Pro Gly Lys 450 <210> 50 <211> 218 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 50 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Ser Gly 20 25 30 Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 35 40 45 Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 65 70 75 80 Ser Val Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Asn Arg 85 90 95 Glu Leu Pro Val Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 100 105 110 Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 115 120 125 Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 130 135 140 Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 145 150 155 160 Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 165 170 175 Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 180 185 190 His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 195 200 205 Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 210 215 <210> 51 <211> 452 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 51 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Thr Ile Ser Glu Tyr Gly Gly Ser Tyr Thr Tyr Tyr Ala Glu Ser 50 55 60 Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 65 70 75 80 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Pro Pro Tyr Asp Asp Tyr Tyr Gly Gly Phe Arg Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 115 120 125 Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 130 135 140 Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 145 150 155 160 Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 165 170 175 Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 180 185 190 Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 195 200 205 His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 210 215 220 Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 225 230 235 240 Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 245 250 255 Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 260 265 270 His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 275 280 285 Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 290 295 300 Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 305 310 315 320 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 325 330 335 Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 340 345 350 Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 355 360 365 Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 370 375 380 Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 385 390 395 400 Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 405 410 415 Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 420 425 430 Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 435 440 445 Ser Pro Gly Lys 450 <210> 52 <211> 452 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 52 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Thr Ile Ser Glu Tyr Gly Gly Ser Tyr Thr Tyr Tyr Ala Glu Ser 50 55 60 Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 65 70 75 80 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Pro Pro Tyr Asp Asp Tyr Tyr Gly Gly Phe Arg Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 115 120 125 Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 130 135 140 Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 145 150 155 160 Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 165 170 175 Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 180 185 190 Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 195 200 205 His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 210 215 220 Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 225 230 235 240 Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 245 250 255 Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Glu 260 265 270 His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 275 280 285 Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 290 295 300 Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 305 310 315 320 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Phe Pro Ala Pro 325 330 335 Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 340 345 350 Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 355 360 365 Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 370 375 380 Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 385 390 395 400 Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 405 410 415 Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 420 425 430 Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 435 440 445 Ser Pro Gly Lys 450 <210> 53 <211> 452 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 53 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Thr Ile Ser Glu Tyr Gly Gly Ser Tyr Thr Tyr Tyr Ala Glu Ser 50 55 60 Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 65 70 75 80 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Pro Pro Tyr Asp Asp Tyr Tyr Gly Gly Phe Gln Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 115 120 125 Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 130 135 140 Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 145 150 155 160 Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 165 170 175 Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 180 185 190 Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 195 200 205 His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 210 215 220 Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 225 230 235 240 Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 245 250 255 Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 260 265 270 His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 275 280 285 Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 290 295 300 Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 305 310 315 320 Gly Lys Glu Tyr Lys Cys Lys Val Ser Ser Lys Ala Phe Pro Ala Pro 325 330 335 Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 340 345 350 Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 355 360 365 Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 370 375 380 Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 385 390 395 400 Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 405 410 415 Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 420 425 430 Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 435 440 445 Ser Pro Gly Lys 450 <210> 54 <211> 452 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 54 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Thr Ile Ser Glu Tyr Gly Gly Ser Tyr Thr Tyr Tyr Ala Glu Ser 50 55 60 Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 65 70 75 80 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Pro Pro Tyr Asp Asp Tyr Tyr Gly Gly Phe Gln Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 115 120 125 Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 130 135 140 Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 145 150 155 160 Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 165 170 175 Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 180 185 190 Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 195 200 205 His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 210 215 220 Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 225 230 235 240 Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 245 250 255 Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 260 265 270 His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 275 280 285 Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 290 295 300 Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 305 310 315 320 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser 325 330 335 Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 340 345 350 Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 355 360 365 Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 370 375 380 Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 385 390 395 400 Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 405 410 415 Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 420 425 430 Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 435 440 445 Ser Pro Gly Lys 450 <210> 55 <211> 452 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 55 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Thr Ile Ser Glu Tyr Gly Gly Ser Tyr Thr Tyr Tyr Ala Glu Ser 50 55 60 Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 65 70 75 80 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Pro Pro Tyr Asp Asp Tyr Tyr Gly Gly Phe Arg Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 115 120 125 Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 130 135 140 Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 145 150 155 160 Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 165 170 175 Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 180 185 190 Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 195 200 205 His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 210 215 220 Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 225 230 235 240 Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 245 250 255 Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 260 265 270 His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 275 280 285 Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 290 295 300 Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 305 310 315 320 Gly Lys Glu Tyr Lys Cys Lys Val Ser Ser Lys Ala Phe Pro Ala Pro 325 330 335 Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 340 345 350 Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 355 360 365 Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 370 375 380 Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 385 390 395 400 Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 405 410 415 Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 420 425 430 Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 435 440 445 Ser Pro Gly Lys 450 <210> 56 <211> 452 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 56 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Thr Ile Ser Glu Tyr Gly Gly Ser Tyr Thr Tyr Tyr Ala Glu Ser 50 55 60 Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 65 70 75 80 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Pro Pro Tyr Asp Asp Tyr Tyr Gly Gly Phe Arg Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 115 120 125 Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 130 135 140 Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 145 150 155 160 Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 165 170 175 Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 180 185 190 Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 195 200 205 His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 210 215 220 Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 225 230 235 240 Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 245 250 255 Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 260 265 270 His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 275 280 285 Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 290 295 300 Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 305 310 315 320 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser 325 330 335 Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 340 345 350 Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 355 360 365 Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 370 375 380 Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 385 390 395 400 Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 405 410 415 Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 420 425 430 Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 435 440 445 Ser Pro Gly Lys 450 <210> 57 <211> 452 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 57 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Thr Ile Ser Glu Tyr Gly Gly Ser Tyr Thr Tyr Tyr Ala Glu Ser 50 55 60 Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 65 70 75 80 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Pro Pro Tyr Asp Asp Tyr Tyr Gly Gly Phe Arg Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 115 120 125 Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 130 135 140 Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 145 150 155 160 Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 165 170 175 Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 180 185 190 Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 195 200 205 His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 210 215 220 Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 225 230 235 240 Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 245 250 255 Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 260 265 270 His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 275 280 285 Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 290 295 300 Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 305 310 315 320 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser 325 330 335 Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 340 345 350 Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 355 360 365 Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 370 375 380 Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 385 390 395 400 Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 405 410 415 Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 420 425 430 Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 435 440 445 Ser Pro Gly Lys 450 <210> 58 <211> 110 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 58 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 1 5 10 15 Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 65 70 75 80 Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 100 105 110 <210> 59 <211> 343 <212> PRT <213> Homo sapiens <400> 59 Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala 1 5 10 15 Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro 20 25 30 Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu 35 40 45 Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 50 55 60 Asp Leu Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 65 70 75 80 Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 85 90 95 Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 100 105 110 Ser Val Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala 115 120 125 Arg Ala Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly 130 135 140 Phe Ser Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu 145 150 155 160 Leu Ser Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser 165 170 175 Tyr Ser Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val 180 185 190 His Ser Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp 195 200 205 Pro Leu Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro 210 215 220 Thr Leu Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn 225 230 235 240 Val Thr Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr 245 250 255 Trp Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val 260 265 270 Thr Glu Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val 275 280 285 Asn Val Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu 290 295 300 His Asp Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser 305 310 315 320 Ala His Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly 325 330 335 Ser Asn Glu Arg Asn Ile Tyr 340 <210> 60 <211> 342 <212> PRT <213> Macaca fascicularis <400> 60 Glu Glu Glu Leu Gln Val Ile Gln Pro Glu Lys Ser Val Ser Val Ala 1 5 10 15 Ala Gly Asp Ser Ala Thr Leu Asn Cys Thr Val Ser Ser Leu Ile Pro 20 25 30 Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu 35 40 45 Ile Tyr Asn Leu Lys Glu Gly His Phe Pro Arg Val Thr Pro Val Ser 50 55 60 Asp Pro Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Ser Asn 65 70 75 80 Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 85 90 95 Gly Ser Pro Asp Val Glu Leu Lys Ser Gly Ala Gly Thr Glu Leu Ser 100 105 110 Val Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Val Arg 115 120 125 Ala Thr Ala Glu His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe 130 135 140 Ser Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu 145 150 155 160 Ser Asp Phe Gln Thr Asn Val Asp Pro Ala Gly Lys Ser Val Ser Tyr 165 170 175 Ser Ile Arg Ser Thr Ala Arg Val Val Leu Thr Arg Arg Asp Val His 180 185 190 Ser Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro 195 200 205 Leu Arg Gly Thr Ala Asn Leu Ser Glu Ala Ile Arg Val Pro Pro Phe 210 215 220 Leu Glu Val Thr Gln Gln Ser Met Arg Ala Asp Asn Gln Val Asn Val 225 230 235 240 Thr Cys Gln Val Thr Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp 245 250 255 Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Met Ala Ser Ala Leu Pro 260 265 270 Glu Asn Lys Asp Gly Thr Tyr Asn Trp Thr Ser Trp Leu Leu Val Asn 275 280 285 Val Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His 290 295 300 Asp Gly Gln Pro Ala Val Asn Lys Ser Phe Ser Val Lys Val Ser Ala 305 310 315 320 His Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly Thr 325 330 335 Asn Glu Arg Asn Ile Tyr 340 <210> 61 <211> 343 <212> PRT <213> Callithrix jacchus <400> 61 Glu Glu Glu Leu Gln Val Val Gln Pro Glu Lys Ser Val Ser Val Ala 1 5 10 15 Ala Gly Glu Thr Ala Thr Leu His Cys Thr Val Thr Ser Leu Val Pro 20 25 30 Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu 35 40 45 Ile Tyr Asn Gln Lys Glu Gly Gln Phe Pro Arg Val Thr Ala Val Ala 50 55 60 Asp Gln Thr Lys Arg Asn Asn Met Asp His Ser Ile Arg Ile Ser Asn 65 70 75 80 Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 85 90 95 Ala Ser Pro Ile Asp Val Glu Leu Lys Ser Gly Pro Gly Thr Glu Leu 100 105 110 Ser Val Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Thr 115 120 125 Arg Val Thr Pro Glu Asp Thr Val Ser Phe Thr Cys Glu Ser His Gly 130 135 140 Phe Ser Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Ala Asn Glu 145 150 155 160 Leu Ser Ala Leu Gln Thr Thr Val Asp Pro Ala Gly Glu Ser Val Ser 165 170 175 Tyr Ser Ile Arg Ser Thr Ala Arg Val Gly Leu Thr Arg Gly Asp Val 180 185 190 Arg Ser Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp 195 200 205 Pro Leu Arg Gly Thr Ala Asn Leu Ser Glu Ala Ile Arg Val Pro Pro 210 215 220 Thr Leu Glu Val Thr His Gln Pro Met Arg Ala Glu Asn Gln Val Asn 225 230 235 240 Val Thr Cys Gln Val Lys Lys Phe Tyr Pro Gln Ser Leu Gln Leu Thr 245 250 255 Trp Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Leu 260 265 270 Ile Glu Asn Lys Asp Gly Thr Tyr Asn Trp Ala Ser Trp Leu Leu Val 275 280 285 Asn Ser Ser Ala His Arg Asp Gly Val Val Leu Thr Cys Gln Val Glu 290 295 300 His Asp Gly Gln Pro Ala Val Ser Lys Ser Leu Arg Leu Glu Val Ser 305 310 315 320 Ala His Arg Lys Glu Gln Gly Ser Asp Thr Ala Ala Glu Lys Thr Gly 325 330 335 Thr Asn Glu Arg Asn Ile Tyr 340 <210> 62 <211> 342 <212> PRT <213> Oryctolagus cuniculus <400> 62 Gln Glu Lys Leu Gln Val Thr Gln Pro Asp Arg Trp Val Ser Val Ala 1 5 10 15 Glu Gly Glu Ala Ala Thr Leu Arg Cys Thr Ile Asn Thr Leu Leu Pro 20 25 30 Val Gly Pro Met Lys Trp Phe Arg Gly Ala Gly Pro Asp Arg Lys Met 35 40 45 Ile Tyr Asn Phe Lys Gly Asp Gln Asp Pro Arg Val Thr Asn Val Ser 50 55 60 Asp Thr Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Arg Asp 65 70 75 80 Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Gln Lys 85 90 95 Lys Gly Ala Asp Asp Glu Glu Phe Lys Ser Gly Gly Gly Thr Gln Val 100 105 110 Ser Val Ser Ala Lys Pro Ser Thr Pro Lys Val Ser Gly Pro Gly Ala 115 120 125 Arg Ser Thr Pro Glu Gln Thr Val Asp Phe Thr Cys Glu Ser His Gly 130 135 140 Phe Ser Pro Arg Asn Ile Ser Leu Lys Trp Phe Lys Asn Gly Asn Glu 145 150 155 160 Leu Pro Ala Phe Gln Thr Ser Val Tyr Pro Ala Gly Glu Ser Val Ser 165 170 175 Tyr Asn Val Thr Ser Thr Val Lys Val Ala Leu Ala Ser Ser Asp Val 180 185 190 His Ser Gln Val Ile Cys Glu Val Ala His Ile Thr Leu Gln Gly Gly 195 200 205 Ser Pro Leu Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro 210 215 220 Pro Thr Val Glu Val Thr Gln Gln Pro Met Gly Ala Gly Thr Gln Val 225 230 235 240 Asn Val Thr Cys His Val Asp Lys Phe Tyr Pro Arg Asp Met Gln Leu 245 250 255 Ser Trp Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Trp Thr 260 265 270 Leu Val Glu Asn Lys Asp Gly Thr Tyr Asn Arg Thr Ser Trp Leu Leu 275 280 285 Val Asn Ser Ser Ala His Arg Glu Asp Val Val Leu Ser Cys Gln Val 290 295 300 Glu His Asp Gly Gln Pro Ala Val Thr Arg Ser His Thr Leu Gln Val 305 310 315 320 Ser Ala Pro Pro Lys Glu Gln Gly Thr Asp Thr Ser Leu Asp Gln Ala 325 330 335 Asp Asn Trp Asn Val Phe 340 <210> 63 <211> 343 <212> PRT <213> Canis familiaris <400> 63 Glu Ala Glu Leu Gln Val Ile Gln Pro Glu Lys Ser Val Ser Val Ala 1 5 10 15 Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Leu Thr Ser Leu Ile Pro 20 25 30 Val Gly Lys Val Glu Trp Phe Arg Gly Thr Gly Pro Gly Arg Glu Leu 35 40 45 Ile Phe His Phe Lys Gly Gly His Phe Pro Arg Val Thr Asn Val Ser 50 55 60 Asp Ser Thr Lys Arg Asn Asn Thr Asp Phe Ser Ile Arg Ile Ser Asn 65 70 75 80 Ile Thr Pro Ala Asp Thr Gly Thr Tyr Tyr Cys Val Lys Phe Gln Lys 85 90 95 Gly Asn Pro Asp Val Glu Leu Lys Ser Gly Pro Gly Thr Leu Val Thr 100 105 110 Val Ser Ala Lys Pro Ser Pro Pro Val Val Ser Gly Pro Thr Ala Arg 115 120 125 Ala Thr Pro Gln Gln Thr Val Asn Phe Thr Cys Lys Ser His Gly Phe 130 135 140 Ser Pro Arg Asn Ile Thr Leu Arg Trp Phe Lys Asn Gly Asn Glu Leu 145 150 155 160 Thr Ala Ser Gln Thr Thr Val Tyr Pro Glu Glu Asp Asn Ala Ser Tyr 165 170 175 Ser Ile Ser Ser Thr Thr Lys Leu Val Leu Ala Pro Gly Asp Val Arg 180 185 190 Ser Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Gly Pro 195 200 205 Pro Leu Arg Gly Thr Ala Asn Leu Ser Glu Thr Leu Arg Val Pro Pro 210 215 220 Thr Leu Glu Val Ser Gln His Pro Met Ala Gly Asp Gln Val Asn Val 225 230 235 240 Thr Cys Gln Val Lys Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp 245 250 255 Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Pro Ser Val Ala Ser 260 265 270 Asn Leu Leu Glu Asn Lys Asp Gly Thr Phe Asn Trp Thr Ser Trp Leu 275 280 285 Leu Val Asn Ser Ser Thr His Arg Glu Asp Val Val Phe Thr Cys Gln 290 295 300 Val Gln His Asp Gly Gln Pro Ala Val Thr Lys Asn His Thr Leu Val 305 310 315 320 Ala Ser Ala Arg Gln Lys Asp Gln Glu Thr Leu Lys Pro Glu Asp Asn 325 330 335 Asn Asp Ser Arg Ser Ile Phe 340 <210> 64 <211> 98 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 64 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys <210> 65 <211> 15 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 65 Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 1 5 10 15 <210> 66 <211> 96 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 66 Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 85 90 95 <210> 67 <211> 12 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 67 Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 1 5 10 <210> 68 <211> 111 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 68 Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Ser Val Ser Ser Ser 20 25 30 Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 35 40 45 Arg Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 65 70 75 80 Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Asn Arg 85 90 95 Glu Leu Pro Cys Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 69 <211> 111 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 69 Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Ser Ser 20 25 30 Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 35 40 45 Arg Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 65 70 75 80 Ser Val Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Asn Arg 85 90 95 Glu Leu Pro Cys Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 70 <211> 111 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido de síntesis" <400> 70 Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Ser Ser 20 25 30 Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 35 40 45 Arg Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 65 70 75 80 Ser Val Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Asn Arg 85 90 95 Glu Leu Pro Ser Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110