LISTADO DE SECUENCIAS <110> Astellas Pharma Inc. <120> ÁCIDO NUCLEICO PARA TRATAR LA ALERGIA A LOS MARISCOS <130> A19003A00 <150> JP2018-091989 <151> 2018-05-11 <160> 3 <170> PatentIn version 3.5 <210> 1 <211> 3249 <212> DNA <213> Secuencia Artificial <220> <223> Ácido nucleico que codifica una proteína quimérica <220> <221> CDS <222> (1)..(3249) <400> 1 atg gcg ccc cgc agc gcc cgg cga ccc ctg ctg ctg cta ctg ctg ttg 48 Met Ala Pro Arg Ser Ala Arg Arg Pro Leu Leu Leu Leu Leu Leu Leu 1 5 10 15 ctg ctg ctc ggc ctc atg cat tgt gcg tca gca gca atg ttt atg gtg 96 Leu Leu Leu Gly Leu Met His Cys Ala Ser Ala Ala Met Phe Met Val 20 25 30 aaa aat ggc aac ggg acc gcg tgc ata atg gcc aac ttc tct gct gcc 144 Lys Asn Gly Asn Gly Thr Ala Cys Ile Met Ala Asn Phe Ser Ala Ala 35 40 45 ttc tca gtg aac tac gac acc aag agt ggc cct aag aac atg acc ctt 192 Phe Ser Val Asn Tyr Asp Thr Lys Ser Gly Pro Lys Asn Met Thr Leu 50 55 60 gac ctg cca tca gat gcc aca gtg gtg ctc aac cgc agc tcc tgt gga 240 Asp Leu Pro Ser Asp Ala Thr Val Val Leu Asn Arg Ser Ser Cys Gly 65 70 75 80 aaa gag aac act tct gac ccc agt ctc gtg att gct ttt gga aga gga 288 Lys Glu Asn Thr Ser Asp Pro Ser Leu Val Ile Ala Phe Gly Arg Gly 85 90 95 cat aca ctc act ctc aat ttc acg aga aat gca aca cgt tac agc gtc 336 His Thr Leu Thr Leu Asn Phe Thr Arg Asn Ala Thr Arg Tyr Ser Val 100 105 110 cag ctc atg agt ttt gtt tat aac ttg tca gac aca cac ctt ttc ccc 384 Gln Leu Met Ser Phe Val Tyr Asn Leu Ser Asp Thr His Leu Phe Pro 115 120 125 aat gcg agc tcc aaa gaa atc aag act gtg gaa tct ata act gac atc 432 Asn Ala Ser Ser Lys Glu Ile Lys Thr Val Glu Ser Ile Thr Asp Ile 130 135 140 agg gca gat ata gat aaa aaa tac aga tgt gtt agt ggc acc cag gtc 480 Arg Ala Asp Ile Asp Lys Lys Tyr Arg Cys Val Ser Gly Thr Gln Val 145 150 155 160 cac atg aac aac gtg acc gta acg ctc cat gat gcc acc atc cag gcg 528 His Met Asn Asn Val Thr Val Thr Leu His Asp Ala Thr Ile Gln Ala 165 170 175 tac ctt tcc aac agc agc ttc agc cgg gga gag aca cgc tgt gaa caa 576 Tyr Leu Ser Asn Ser Ser Phe Ser Arg Gly Glu Thr Arg Cys Glu Gln 180 185 190 gac agg cct tcc cca acc aca gcg ccc cct gcg cca ccc agc ccc tcg 624 Asp Arg Pro Ser Pro Thr Thr Ala Pro Pro Ala Pro Pro Ser Pro Ser 195 200 205 ccc tca ccc gtg ccc aag agc ccc tct gtg gac aag tac aac gtg agc 672 Pro Ser Pro Val Pro Lys Ser Pro Ser Val Asp Lys Tyr Asn Val Ser 210 215 220 ggc acc aac ggg acc tgc ctg ctg gcc agc atg ggg ctg cag ctg aac 720 Gly Thr Asn Gly Thr Cys Leu Leu Ala Ser Met Gly Leu Gln Leu Asn 225 230 235 240 ctc acc tat gag agg aag gac aac acg acg gtg aca agg ctt ctc aac 768 Leu Thr Tyr Glu Arg Lys Asp Asn Thr Thr Val Thr Arg Leu Leu Asn 245 250 255 atc aac ccc aac aag acc tcg gcc agc ggg agc tgc ggc gcc cac ctg 816 Ile Asn Pro Asn Lys Thr Ser Ala Ser Gly Ser Cys Gly Ala His Leu 260 265 270 gtg act ctg gag ctg cac agc gag ggc acc acc gtc ctg ctc ttc cag 864 Val Thr Leu Glu Leu His Ser Glu Gly Thr Thr Val Leu Leu Phe Gln 275 280 285 ttc ggg atg aat gca agt tct agc cgg ttt ttc cta caa gga atc cag 912 Phe Gly Met Asn Ala Ser Ser Ser Arg Phe Phe Leu Gln Gly Ile Gln 290 295 300 ttg aat aca att ctt cct gac gcc aga gac cct gcc ttt aaa gct gcc 960 Leu Asn Thr Ile Leu Pro Asp Ala Arg Asp Pro Ala Phe Lys Ala Ala 305 310 315 320 aac ggc tcc ctg cga gcg ctg cag gcc aca gtc ggc aat tcc tac aag 1008 Asn Gly Ser Leu Arg Ala Leu Gln Ala Thr Val Gly Asn Ser Tyr Lys 325 330 335 tgc aac gcg gag gag cac gtc cgt gtc acg aag gcg ttt tca gtc aat 1056 Cys Asn Ala Glu Glu His Val Arg Val Thr Lys Ala Phe Ser Val Asn 340 345 350 ata ttc aaa gtg tgg gtc cag gct ttc aag gtg gaa ggt ggc cag ttt 1104 Ile Phe Lys Val Trp Val Gln Ala Phe Lys Val Glu Gly Gly Gln Phe 355 360 365 ggc tct gtg gag gag tgt ctg ctg gac gag aac agc ctc gag atg gac 1152 Gly Ser Val Glu Glu Cys Leu Leu Asp Glu Asn Ser Leu Glu Met Asp 370 375 380 gcc ata aag aag aaa atg caa gcg atg aaa ctg gag aag gat aac gcc 1200 Ala Ile Lys Lys Lys Met Gln Ala Met Lys Leu Glu Lys Asp Asn Ala 385 390 395 400 atg gat cgg gct gat acg ctg gaa cag cag aat aag gaa gca aac aat 1248 Met Asp Arg Ala Asp Thr Leu Glu Gln Gln Asn Lys Glu Ala Asn Asn 405 410 415 cgt gca gaa aag tcc gaa gaa gag gtt cac aac ctt cag aag aga atg 1296 Arg Ala Glu Lys Ser Glu Glu Glu Val His Asn Leu Gln Lys Arg Met 420 425 430 cag caa ctg gag aat gac ctg gat cag gtg caa gag agc ctg ctg aag 1344 Gln Gln Leu Glu Asn Asp Leu Asp Gln Val Gln Glu Ser Leu Leu Lys 435 440 445 gcc aac atc caa ctg gtc gag aag gat aag gcc ctt agt aac gcc gaa 1392 Ala Asn Ile Gln Leu Val Glu Lys Asp Lys Ala Leu Ser Asn Ala Glu 450 455 460 ggc gag gta gcc gcc ttg aat cgt cgc att caa ctt ctt gag gag gac 1440 Gly Glu Val Ala Ala Leu Asn Arg Arg Ile Gln Leu Leu Glu Glu Asp 465 470 475 480 ctt gag aga tcc gaa gag aga ctg aac acc gct acc acc aaa ctg gca 1488 Leu Glu Arg Ser Glu Glu Arg Leu Asn Thr Ala Thr Thr Lys Leu Ala 485 490 495 gaa gca agc caa gct gcc gat gag tct gaa cgc atg cgc aag gta ttg 1536 Glu Ala Ser Gln Ala Ala Asp Glu Ser Glu Arg Met Arg Lys Val Leu 500 505 510 gag aac agg agc ttg tct gat gag gaa cgc atg gat gcg ttg gag aat 1584 Glu Asn Arg Ser Leu Ser Asp Glu Glu Arg Met Asp Ala Leu Glu Asn 515 520 525 cag ctc aag gaa gca cgg ttc ctg gcc gag gaa gcg gat agg aag tat 1632 Gln Leu Lys Glu Ala Arg Phe Leu Ala Glu Glu Ala Asp Arg Lys Tyr 530 535 540 gat gag gtg gca cga aaa ctc gca atg gtg gag gca gac ttg gaa aga 1680 Asp Glu Val Ala Arg Lys Leu Ala Met Val Glu Ala Asp Leu Glu Arg 545 550 555 560 gct gaa gag aga gct gag aca ggc gag tct aaa atc gtg gaa ctg gag 1728 Ala Glu Glu Arg Ala Glu Thr Gly Glu Ser Lys Ile Val Glu Leu Glu 565 570 575 gaa gaa ctg cgg gtt gtg ggc aac aac ctc aag tca ctg gaa gtg tca 1776 Glu Glu Leu Arg Val Val Gly Asn Asn Leu Lys Ser Leu Glu Val Ser 580 585 590 gaa gag aaa gcc aac caa agg gaa gag gcc tat aaa gag cag atc aaa 1824 Glu Glu Lys Ala Asn Gln Arg Glu Glu Ala Tyr Lys Glu Gln Ile Lys 595 600 605 acc ctg act aac aag ctc aaa gcc gca gag gct cgc gct gaa ttt gct 1872 Thr Leu Thr Asn Lys Leu Lys Ala Ala Glu Ala Arg Ala Glu Phe Ala 610 615 620 gag cgg tca gtg cag aaa ctg cag aag gaa gtg gac agg ctg gag gat 1920 Glu Arg Ser Val Gln Lys Leu Gln Lys Glu Val Asp Arg Leu Glu Asp 625 630 635 640 gag ctc gtc aat gag aaa gag aaa tac aag tcc att aca gac gag ctg 1968 Glu Leu Val Asn Glu Lys Glu Lys Tyr Lys Ser Ile Thr Asp Glu Leu 645 650 655 gat cag acc ttc agt gag ctc tca ggc tac gga gga ggt ggg atg gcc 2016 Asp Gln Thr Phe Ser Glu Leu Ser Gly Tyr Gly Gly Gly Gly Met Ala 660 665 670 tat agc tgg gat aat cgc gtg aag tac gtg gtg cgg tac atg tac gat 2064 Tyr Ser Trp Asp Asn Arg Val Lys Tyr Val Val Arg Tyr Met Tyr Asp 675 680 685 atc gac aac aac ggg ttt ctc gac aag aac gat ttc gaa tgc ctt gcc 2112 Ile Asp Asn Asn Gly Phe Leu Asp Lys Asn Asp Phe Glu Cys Leu Ala 690 695 700 gta cgg aac aca ctg att gag gga agg ggt gag ttt tcc gcc gat gcc 2160 Val Arg Asn Thr Leu Ile Glu Gly Arg Gly Glu Phe Ser Ala Asp Ala 705 710 715 720 tac gcg aac aat cag aaa atc atg cga aac ttg tgg aat gag att gcc 2208 Tyr Ala Asn Asn Gln Lys Ile Met Arg Asn Leu Trp Asn Glu Ile Ala 725 730 735 gaa ctg gcc gac ttc aat aag gat ggg gaa gtt act gtc gac gag ttc 2256 Glu Leu Ala Asp Phe Asn Lys Asp Gly Glu Val Thr Val Asp Glu Phe 740 745 750 aaa cag gca gtg cag aaa cac tgt cag ggc aag aag tat gga gac ttc 2304 Lys Gln Ala Val Gln Lys His Cys Gln Gly Lys Lys Tyr Gly Asp Phe 755 760 765 cca ggc gct ttc aaa gtt ttc ata gcc aac cag ttc aaa gca ata gac 2352 Pro Gly Ala Phe Lys Val Phe Ile Ala Asn Gln Phe Lys Ala Ile Asp 770 775 780 gta aat ggg gat ggg aag gtt ggg ctc gat gag tat cga ctg gac tgc 2400 Val Asn Gly Asp Gly Lys Val Gly Leu Asp Glu Tyr Arg Leu Asp Cys 785 790 795 800 ata act cga tcc gcc ttt gcc gag gtc aaa gag atc gat gac gcg tat 2448 Ile Thr Arg Ser Ala Phe Ala Glu Val Lys Glu Ile Asp Asp Ala Tyr 805 810 815 aac aaa ctg acc act gaa gat gac cgc aag gct ggt ggg ctg aca ctc 2496 Asn Lys Leu Thr Thr Glu Asp Asp Arg Lys Ala Gly Gly Leu Thr Leu 820 825 830 gaa agg tac cag gat ctg tat gcc cag ttt atc agc aat ccc gac gaa 2544 Glu Arg Tyr Gln Asp Leu Tyr Ala Gln Phe Ile Ser Asn Pro Asp Glu 835 840 845 agc tgt tct gcc tgt tac ctc ttt ggc ccg ctg aaa gtc gtc caa gga 2592 Ser Cys Ser Ala Cys Tyr Leu Phe Gly Pro Leu Lys Val Val Gln Gly 850 855 860 gga ggc ggg atg tca cgg aag agc ggc tct cgg agt tcc agc aag agg 2640 Gly Gly Gly Met Ser Arg Lys Ser Gly Ser Arg Ser Ser Ser Lys Arg 865 870 875 880 agc aag aag tct gga ggc ggt tcc aat gtc ttt gac atg ttt acc cag 2688 Ser Lys Lys Ser Gly Gly Gly Ser Asn Val Phe Asp Met Phe Thr Gln 885 890 895 aga cag gtg gct gaa ttt aaa gag gga ttt cag ctg atg gac cgt gac 2736 Arg Gln Val Ala Glu Phe Lys Glu Gly Phe Gln Leu Met Asp Arg Asp 900 905 910 aaa gac gga gtt atc ggt aag act gac ttg aga ggt acg ttc gat gag 2784 Lys Asp Gly Val Ile Gly Lys Thr Asp Leu Arg Gly Thr Phe Asp Glu 915 920 925 att ggc aga atc gcc act gac cag gag ctg gat gag atg ctg gcg gac 2832 Ile Gly Arg Ile Ala Thr Asp Gln Glu Leu Asp Glu Met Leu Ala Asp 930 935 940 gct cct gca ccc atc aat ttc acc atg ctt ctc aat atg ttc gcc gag 2880 Ala Pro Ala Pro Ile Asn Phe Thr Met Leu Leu Asn Met Phe Ala Glu 945 950 955 960 aga caa aca gga gaa agt gac gac gac gac gtg gtg gct aag gct ttc 2928 Arg Gln Thr Gly Glu Ser Asp Asp Asp Asp Val Val Ala Lys Ala Phe 965 970 975 ctg gcc ttt gct gat gag gaa ggg aat att gat tgc gac acg ttc agg 2976 Leu Ala Phe Ala Asp Glu Glu Gly Asn Ile Asp Cys Asp Thr Phe Arg 980 985 990 cat gct ctg atg aca tgg ggc gac aaa ttt agc agt cag gaa gca gac 3024 His Ala Leu Met Thr Trp Gly Asp Lys Phe Ser Ser Gln Glu Ala Asp 995 1000 1005 gat gcc ctg gac cag atg gat att gac gac ggc ggg aag atc gat 3069 Asp Ala Leu Asp Gln Met Asp Ile Asp Asp Gly Gly Lys Ile Asp 1010 1015 1020 gtg cag gga gtc att cag atg ctg aca gca ggc ggt ggg gat gac 3114 Val Gln Gly Val Ile Gln Met Leu Thr Ala Gly Gly Gly Asp Asp 1025 1030 1035 gca gct gct gaa gag gcg gaa ttc acg ctg atc ccc atc gct gtg 3159 Ala Ala Ala Glu Glu Ala Glu Phe Thr Leu Ile Pro Ile Ala Val 1040 1045 1050 ggt ggt gcc ctg gcg ggg ctg gtc ctc atc gtc ctc atc gcc tac 3204 Gly Gly Ala Leu Ala Gly Leu Val Leu Ile Val Leu Ile Ala Tyr 1055 1060 1065 ctc gtc ggc agg aag agg agt cac gca ggc tac cag act atc tag 3249 Leu Val Gly Arg Lys Arg Ser His Ala Gly Tyr Gln Thr Ile 1070 1075 1080 <210> 2 <211> 1082 <212> PRT <213> Secuencia Artificial <220> <223> Constructo Sintético <400> 2 Met Ala Pro Arg Ser Ala Arg Arg Pro Leu Leu Leu Leu Leu Leu Leu 1 5 10 15 Leu Leu Leu Gly Leu Met His Cys Ala Ser Ala Ala Met Phe Met Val 20 25 30 Lys Asn Gly Asn Gly Thr Ala Cys Ile Met Ala Asn Phe Ser Ala Ala 35 40 45 Phe Ser Val Asn Tyr Asp Thr Lys Ser Gly Pro Lys Asn Met Thr Leu 50 55 60 Asp Leu Pro Ser Asp Ala Thr Val Val Leu Asn Arg Ser Ser Cys Gly 65 70 75 80 Lys Glu Asn Thr Ser Asp Pro Ser Leu Val Ile Ala Phe Gly Arg Gly 85 90 95 His Thr Leu Thr Leu Asn Phe Thr Arg Asn Ala Thr Arg Tyr Ser Val 100 105 110 Gln Leu Met Ser Phe Val Tyr Asn Leu Ser Asp Thr His Leu Phe Pro 115 120 125 Asn Ala Ser Ser Lys Glu Ile Lys Thr Val Glu Ser Ile Thr Asp Ile 130 135 140 Arg Ala Asp Ile Asp Lys Lys Tyr Arg Cys Val Ser Gly Thr Gln Val 145 150 155 160 His Met Asn Asn Val Thr Val Thr Leu His Asp Ala Thr Ile Gln Ala 165 170 175 Tyr Leu Ser Asn Ser Ser Phe Ser Arg Gly Glu Thr Arg Cys Glu Gln 180 185 190 Asp Arg Pro Ser Pro Thr Thr Ala Pro Pro Ala Pro Pro Ser Pro Ser 195 200 205 Pro Ser Pro Val Pro Lys Ser Pro Ser Val Asp Lys Tyr Asn Val Ser 210 215 220 Gly Thr Asn Gly Thr Cys Leu Leu Ala Ser Met Gly Leu Gln Leu Asn 225 230 235 240 Leu Thr Tyr Glu Arg Lys Asp Asn Thr Thr Val Thr Arg Leu Leu Asn 245 250 255 Ile Asn Pro Asn Lys Thr Ser Ala Ser Gly Ser Cys Gly Ala His Leu 260 265 270 Val Thr Leu Glu Leu His Ser Glu Gly Thr Thr Val Leu Leu Phe Gln 275 280 285 Phe Gly Met Asn Ala Ser Ser Ser Arg Phe Phe Leu Gln Gly Ile Gln 290 295 300 Leu Asn Thr Ile Leu Pro Asp Ala Arg Asp Pro Ala Phe Lys Ala Ala 305 310 315 320 Asn Gly Ser Leu Arg Ala Leu Gln Ala Thr Val Gly Asn Ser Tyr Lys 325 330 335 Cys Asn Ala Glu Glu His Val Arg Val Thr Lys Ala Phe Ser Val Asn 340 345 350 Ile Phe Lys Val Trp Val Gln Ala Phe Lys Val Glu Gly Gly Gln Phe 355 360 365 Gly Ser Val Glu Glu Cys Leu Leu Asp Glu Asn Ser Leu Glu Met Asp 370 375 380 Ala Ile Lys Lys Lys Met Gln Ala Met Lys Leu Glu Lys Asp Asn Ala 385 390 395 400 Met Asp Arg Ala Asp Thr Leu Glu Gln Gln Asn Lys Glu Ala Asn Asn 405 410 415 Arg Ala Glu Lys Ser Glu Glu Glu Val His Asn Leu Gln Lys Arg Met 420 425 430 Gln Gln Leu Glu Asn Asp Leu Asp Gln Val Gln Glu Ser Leu Leu Lys 435 440 445 Ala Asn Ile Gln Leu Val Glu Lys Asp Lys Ala Leu Ser Asn Ala Glu 450 455 460 Gly Glu Val Ala Ala Leu Asn Arg Arg Ile Gln Leu Leu Glu Glu Asp 465 470 475 480 Leu Glu Arg Ser Glu Glu Arg Leu Asn Thr Ala Thr Thr Lys Leu Ala 485 490 495 Glu Ala Ser Gln Ala Ala Asp Glu Ser Glu Arg Met Arg Lys Val Leu 500 505 510 Glu Asn Arg Ser Leu Ser Asp Glu Glu Arg Met Asp Ala Leu Glu Asn 515 520 525 Gln Leu Lys Glu Ala Arg Phe Leu Ala Glu Glu Ala Asp Arg Lys Tyr 530 535 540 Asp Glu Val Ala Arg Lys Leu Ala Met Val Glu Ala Asp Leu Glu Arg 545 550 555 560 Ala Glu Glu Arg Ala Glu Thr Gly Glu Ser Lys Ile Val Glu Leu Glu 565 570 575 Glu Glu Leu Arg Val Val Gly Asn Asn Leu Lys Ser Leu Glu Val Ser 580 585 590 Glu Glu Lys Ala Asn Gln Arg Glu Glu Ala Tyr Lys Glu Gln Ile Lys 595 600 605 Thr Leu Thr Asn Lys Leu Lys Ala Ala Glu Ala Arg Ala Glu Phe Ala 610 615 620 Glu Arg Ser Val Gln Lys Leu Gln Lys Glu Val Asp Arg Leu Glu Asp 625 630 635 640 Glu Leu Val Asn Glu Lys Glu Lys Tyr Lys Ser Ile Thr Asp Glu Leu 645 650 655 Asp Gln Thr Phe Ser Glu Leu Ser Gly Tyr Gly Gly Gly Gly Met Ala 660 665 670 Tyr Ser Trp Asp Asn Arg Val Lys Tyr Val Val Arg Tyr Met Tyr Asp 675 680 685 Ile Asp Asn Asn Gly Phe Leu Asp Lys Asn Asp Phe Glu Cys Leu Ala 690 695 700 Val Arg Asn Thr Leu Ile Glu Gly Arg Gly Glu Phe Ser Ala Asp Ala 705 710 715 720 Tyr Ala Asn Asn Gln Lys Ile Met Arg Asn Leu Trp Asn Glu Ile Ala 725 730 735 Glu Leu Ala Asp Phe Asn Lys Asp Gly Glu Val Thr Val Asp Glu Phe 740 745 750 Lys Gln Ala Val Gln Lys His Cys Gln Gly Lys Lys Tyr Gly Asp Phe 755 760 765 Pro Gly Ala Phe Lys Val Phe Ile Ala Asn Gln Phe Lys Ala Ile Asp 770 775 780 Val Asn Gly Asp Gly Lys Val Gly Leu Asp Glu Tyr Arg Leu Asp Cys 785 790 795 800 Ile Thr Arg Ser Ala Phe Ala Glu Val Lys Glu Ile Asp Asp Ala Tyr 805 810 815 Asn Lys Leu Thr Thr Glu Asp Asp Arg Lys Ala Gly Gly Leu Thr Leu 820 825 830 Glu Arg Tyr Gln Asp Leu Tyr Ala Gln Phe Ile Ser Asn Pro Asp Glu 835 840 845 Ser Cys Ser Ala Cys Tyr Leu Phe Gly Pro Leu Lys Val Val Gln Gly 850 855 860 Gly Gly Gly Met Ser Arg Lys Ser Gly Ser Arg Ser Ser Ser Lys Arg 865 870 875 880 Ser Lys Lys Ser Gly Gly Gly Ser Asn Val Phe Asp Met Phe Thr Gln 885 890 895 Arg Gln Val Ala Glu Phe Lys Glu Gly Phe Gln Leu Met Asp Arg Asp 900 905 910 Lys Asp Gly Val Ile Gly Lys Thr Asp Leu Arg Gly Thr Phe Asp Glu 915 920 925 Ile Gly Arg Ile Ala Thr Asp Gln Glu Leu Asp Glu Met Leu Ala Asp 930 935 940 Ala Pro Ala Pro Ile Asn Phe Thr Met Leu Leu Asn Met Phe Ala Glu 945 950 955 960 Arg Gln Thr Gly Glu Ser Asp Asp Asp Asp Val Val Ala Lys Ala Phe 965 970 975 Leu Ala Phe Ala Asp Glu Glu Gly Asn Ile Asp Cys Asp Thr Phe Arg 980 985 990 His Ala Leu Met Thr Trp Gly Asp Lys Phe Ser Ser Gln Glu Ala Asp 995 1000 1005 Asp Ala Leu Asp Gln Met Asp Ile Asp Asp Gly Gly Lys Ile Asp 1010 1015 1020 Val Gln Gly Val Ile Gln Met Leu Thr Ala Gly Gly Gly Asp Asp 1025 1030 1035 Ala Ala Ala Glu Glu Ala Glu Phe Thr Leu Ile Pro Ile Ala Val 1040 1045 1050 Gly Gly Ala Leu Ala Gly Leu Val Leu Ile Val Leu Ile Ala Tyr 1055 1060 1065 Leu Val Gly Arg Lys Arg Ser His Ala Gly Tyr Gln Thr Ile 1070 1075 1080 <210> 3 <211> 6253 <212> DNA <213> Secuencia Artificial <220> <223> Un vector que comprende ácido nucleico que codifica una proteína quimérica <400> 3 ccgcctaatg agcgggcttt tttttcttag ggtgcaaaag gagagcctgt aagcgggcac 60 tcttccgtgg tctggtggat aaattcgcaa gggtatcatg gcggacgacc ggggttcgag 120 ccccgtatcc ggccgtccgc cgtgatccat gcggttaccg cccgcgtgtc gaacccaggt 180 gtgcgacgtc agacaacggg ggagtgctcc ttttggcttc cttccccttc ttccgcttcc 240 tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc gagcggtatc agctcactca 300 aaggcggtaa tacggttatc cacagaatca ggggataacg caggaaagaa catgtgagca 360 aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt tttccatagg 420 ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg gcgaaacccg 480 acaggactat aaagatacca ggcgtttccc cctggaagct ccctcgtgcg ctctcctgtt 540 ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc cttcgggaag cgtggcgctt 600 tctcatagct cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc caagctgggc 660 tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct tatccggtaa ctatcgtctt 720 gagtccaacc cggtaagaca cgacttatcg ccactggcag cagccactgg taacaggatt 780 agcagagcga ggtatgtagg cggtgctaca gagttcttga agtggtggcc taactacggc 840 tacactagaa gaacagtatt tggtatctgc gctctgctga agccagttac cttcggaaaa 900 agagttggta gctcttgatc cggcaaacaa accaccgctg gtagcggtgg tttttttgtt 960 tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag aagatccttt gatcttttct 1020 acggggtctg acgctcagtg gaacgaaaac tcacgttaag ggattttggt catgagatta 1080 tcaaaaagga tcttcaccta gatcctttta aattaaaaat gaagttttaa atcaatctaa 1140 agtatatatg agtaaacttg gtctgacagt taccaatgct taatcagtga ggcacctatc 1200 tcagcgatct gtctatttcg ttcatccata gttgcctgac tcctgcaaac cacgttgtgg 1260 tagaattggt aaagagagtc gtgtaaaata tcgagttcgc acatcttgtt gtctgattat 1320 tgatttttgg cgaaaccatt tgatcatatg acaagatgtg tatctacctt aacttaatga 1380 ttttgataaa aatcattagg taccccggct ctagatggca tgacattaac ctataaaaat 1440 aggcgtatca cgaggccctt tcgtctcgcg cgtttcggtg atgacggtga aaacctctga 1500 cacatgcagc tcccggagac ggtcacagct tgtctgtaag cggatgccgg gagcagacaa 1560 gcccgtcagg gcgcgtcagc gggtgttggc gggtgtcggg gctggcttaa ctatgcggca 1620 tcagagcaga ttgtactgag agtgcaccat atgcggtgtg aaataccgca cagatgcgta 1680 aggagaaaat accgcatcag attggctatt ggccattgca tacgttgtat ccatatcata 1740 atatgtacat ttatattggc tcatgtccaa cattaccgcc atgttgacat tgattattga 1800 ctagttatta atagtaatca attacggggt cattagttca tagcccatat atggagttcc 1860 gcgttacata acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat 1920 tgacgtcaat aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc 1980 aatgggtgga gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc 2040 caagtacgcc ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt 2100 acatgacctt atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta 2160 ccatggtgat gcggttttgg cagtacatca atgggcgtgg atagcggttt gactcacggg 2220 gatttccaag tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac 2280 gggactttcc aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg 2340 tacggtggga ggtctatata agcagagctc gtttagtgaa ccgtcagatc gcctggagac 2400 gccatccacg ctgttttgac ctccatagaa gacaccggga ccgatccagc ctccgcggct 2460 cgcatctctc cttcacgcgc ccgccgccct acctgaggcc gccatccacg ccggttgagt 2520 cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg cgtccgccgt ctaggtaagt 2580 ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc cttggagcct acctagactc 2640 agccggctct ccacgctttg cctgaccctg cttgctcaac tctagttctc tcgttaactt 2700 aatgagacag atagaaactg gtcttgtaga aacagagtag tcgcctgctt ttctgccagg 2760 tgctgacttc tctcccctgg gcttttttct ttttctcagg ttgaaaagaa gaagacgaag 2820 aagacgaaga agacaaaccg tcgtcgacat ggcgccccgc agcgcccggc gacccctgct 2880 gctgctactg ctgttgctgc tgctcggcct catgcattgt gcgtcagcag caatgtttat 2940 ggtgaaaaat ggcaacggga ccgcgtgcat aatggccaac ttctctgctg ccttctcagt 3000 gaactacgac accaagagtg gccctaagaa catgaccctt gacctgccat cagatgccac 3060 agtggtgctc aaccgcagct cctgtggaaa agagaacact tctgacccca gtctcgtgat 3120 tgcttttgga agaggacata cactcactct caatttcacg agaaatgcaa cacgttacag 3180 cgtccagctc atgagttttg tttataactt gtcagacaca caccttttcc ccaatgcgag 3240 ctccaaagaa atcaagactg tggaatctat aactgacatc agggcagata tagataaaaa 3300 atacagatgt gttagtggca cccaggtcca catgaacaac gtgaccgtaa cgctccatga 3360 tgccaccatc caggcgtacc tttccaacag cagcttcagc cggggagaga cacgctgtga 3420 acaagacagg ccttccccaa ccacagcgcc ccctgcgcca cccagcccct cgccctcacc 3480 cgtgcccaag agcccctctg tggacaagta caacgtgagc ggcaccaacg ggacctgcct 3540 gctggccagc atggggctgc agctgaacct cacctatgag aggaaggaca acacgacggt 3600 gacaaggctt ctcaacatca accccaacaa gacctcggcc agcgggagct gcggcgccca 3660 cctggtgact ctggagctgc acagcgaggg caccaccgtc ctgctcttcc agttcgggat 3720 gaatgcaagt tctagccggt ttttcctaca aggaatccag ttgaatacaa ttcttcctga 3780 cgccagagac cctgccttta aagctgccaa cggctccctg cgagcgctgc aggccacagt 3840 cggcaattcc tacaagtgca acgcggagga gcacgtccgt gtcacgaagg cgttttcagt 3900 caatatattc aaagtgtggg tccaggcttt caaggtggaa ggtggccagt ttggctctgt 3960 ggaggagtgt ctgctggacg agaacagcct cgagatggac gccataaaga agaaaatgca 4020 agcgatgaaa ctggagaagg ataacgccat ggatcgggct gatacgctgg aacagcagaa 4080 taaggaagca aacaatcgtg cagaaaagtc cgaagaagag gttcacaacc ttcagaagag 4140 aatgcagcaa ctggagaatg acctggatca ggtgcaagag agcctgctga aggccaacat 4200 ccaactggtc gagaaggata aggcccttag taacgccgaa ggcgaggtag ccgccttgaa 4260 tcgtcgcatt caacttcttg aggaggacct tgagagatcc gaagagagac tgaacaccgc 4320 taccaccaaa ctggcagaag caagccaagc tgccgatgag tctgaacgca tgcgcaaggt 4380 attggagaac aggagcttgt ctgatgagga acgcatggat gcgttggaga atcagctcaa 4440 ggaagcacgg ttcctggccg aggaagcgga taggaagtat gatgaggtgg cacgaaaact 4500 cgcaatggtg gaggcagact tggaaagagc tgaagagaga gctgagacag gcgagtctaa 4560 aatcgtggaa ctggaggaag aactgcgggt tgtgggcaac aacctcaagt cactggaagt 4620 gtcagaagag aaagccaacc aaagggaaga ggcctataaa gagcagatca aaaccctgac 4680 taacaagctc aaagccgcag aggctcgcgc tgaatttgct gagcggtcag tgcagaaact 4740 gcagaaggaa gtggacaggc tggaggatga gctcgtcaat gagaaagaga aatacaagtc 4800 cattacagac gagctggatc agaccttcag tgagctctca ggctacggag gaggtgggat 4860 ggcctatagc tgggataatc gcgtgaagta cgtggtgcgg tacatgtacg atatcgacaa 4920 caacgggttt ctcgacaaga acgatttcga atgccttgcc gtacggaaca cactgattga 4980 gggaaggggt gagttttccg ccgatgccta cgcgaacaat cagaaaatca tgcgaaactt 5040 gtggaatgag attgccgaac tggccgactt caataaggat ggggaagtta ctgtcgacga 5100 gttcaaacag gcagtgcaga aacactgtca gggcaagaag tatggagact tcccaggcgc 5160 tttcaaagtt ttcatagcca accagttcaa agcaatagac gtaaatgggg atgggaaggt 5220 tgggctcgat gagtatcgac tggactgcat aactcgatcc gcctttgccg aggtcaaaga 5280 gatcgatgac gcgtataaca aactgaccac tgaagatgac cgcaaggctg gtgggctgac 5340 actcgaaagg taccaggatc tgtatgccca gtttatcagc aatcccgacg aaagctgttc 5400 tgcctgttac ctctttggcc cgctgaaagt cgtccaagga ggaggcggga tgtcacggaa 5460 gagcggctct cggagttcca gcaagaggag caagaagtct ggaggcggtt ccaatgtctt 5520 tgacatgttt acccagagac aggtggctga atttaaagag ggatttcagc tgatggaccg 5580 tgacaaagac ggagttatcg gtaagactga cttgagaggt acgttcgatg agattggcag 5640 aatcgccact gaccaggagc tggatgagat gctggcggac gctcctgcac ccatcaattt 5700 caccatgctt ctcaatatgt tcgccgagag acaaacagga gaaagtgacg acgacgacgt 5760 ggtggctaag gctttcctgg cctttgctga tgaggaaggg aatattgatt gcgacacgtt 5820 caggcatgct ctgatgacat ggggcgacaa atttagcagt caggaagcag acgatgccct 5880 ggaccagatg gatattgacg acggcgggaa gatcgatgtg cagggagtca ttcagatgct 5940 gacagcaggc ggtggggatg acgcagctgc tgaagaggcg gaattcacgc tgatccccat 6000 cgctgtgggt ggtgccctgg cggggctggt cctcatcgtc ctcatcgcct acctcgtcgg 6060 caggaagagg agtcacgcag gctaccagac tatctagtaa ggatcttttt ccctctgcca 6120 aaaattatgg ggacatcatg aagccccttg agcatctgac ttctggctaa taaaggaaat 6180 ttattttcat tgcaatagtg tgttggaatt ttttgtgtct ctcactcgga aggacataag 6240 ggcggccgct agc 6253