SEQUENCE LISTING <110> Astellas Pharma Inc. <120> ÁCIDO NUCLEICO PARA TRATAR ALERGIA A LOS ÁCAROS <130> A19002A00 <150> JP2018-091963 <151> 2018-05-11 <160> 3 <170> PatentIn version 3.5 <210> 1 <211> 3123 <212> DNA <213> Secuencia artificial <220> <223> Acido nucelico que codifica una proteina quimérica <220> <221> CDS <222> (1)..(3123) <400> 1 atg gcg ccc cgc agc gcc cgg cga ccc ctg ctg ctg cta ctg ctg ttg 48 Met Ala Pro Arg Ser Ala Arg Arg Pro Leu Leu Leu Leu Leu Leu Leu 1 5 10 15 ctg ctg ctc ggc ctc atg cat tgt gcg tca gca gca atg ttt atg gtg 96 Leu Leu Leu Gly Leu Met His Cys Ala Ser Ala Ala Met Phe Met Val 20 25 30 aaa aat ggc aac ggg acc gcg tgc ata atg gcc aac ttc tct gct gcc 144 Lys Asn Gly Asn Gly Thr Ala Cys Ile Met Ala Asn Phe Ser Ala Ala 35 40 45 ttc tca gtg aac tac gac acc aag agt ggc cct aag aac atg acc ctt 192 Phe Ser Val Asn Tyr Asp Thr Lys Ser Gly Pro Lys Asn Met Thr Leu 50 55 60 gac ctg cca tca gat gcc aca gtg gtg ctc aac cgc agc tcc tgt gga 240 Asp Leu Pro Ser Asp Ala Thr Val Val Leu Asn Arg Ser Ser Cys Gly 65 70 75 80 aaa gag aac act tct gac ccc agt ctc gtg att gct ttt gga aga gga 288 Lys Glu Asn Thr Ser Asp Pro Ser Leu Val Ile Ala Phe Gly Arg Gly 85 90 95 cat aca ctc act ctc aat ttc acg aga aat gca aca cgt tac agc gtc 336 His Thr Leu Thr Leu Asn Phe Thr Arg Asn Ala Thr Arg Tyr Ser Val 100 105 110 cag ctc atg agt ttt gtt tat aac ttg tca gac aca cac ctt ttc ccc 384 Gln Leu Met Ser Phe Val Tyr Asn Leu Ser Asp Thr His Leu Phe Pro 115 120 125 aat gcg agc tcc aaa gaa atc aag act gtg gaa tct ata act gac atc 432 Asn Ala Ser Ser Lys Glu Ile Lys Thr Val Glu Ser Ile Thr Asp Ile 130 135 140 agg gca gat ata gat aaa aaa tac aga tgt gtt agt ggc acc cag gtc 480 Arg Ala Asp Ile Asp Lys Lys Tyr Arg Cys Val Ser Gly Thr Gln Val 145 150 155 160 cac atg aac aac gtg acc gta acg ctc cat gat gcc acc atc cag gcg 528 His Met Asn Asn Val Thr Val Thr Leu His Asp Ala Thr Ile Gln Ala 165 170 175 tac ctt tcc aac agc agc ttc agc cgg gga gag aca cgc tgt gaa caa 576 Tyr Leu Ser Asn Ser Ser Phe Ser Arg Gly Glu Thr Arg Cys Glu Gln 180 185 190 gac agg cct tcc cca acc aca gcg ccc cct gcg cca ccc agc ccc tcg 624 Asp Arg Pro Ser Pro Thr Thr Ala Pro Pro Ala Pro Pro Ser Pro Ser 195 200 205 ccc tca ccc gtg ccc aag agc ccc tct gtg gac aag tac aac gtg agc 672 Pro Ser Pro Val Pro Lys Ser Pro Ser Val Asp Lys Tyr Asn Val Ser 210 215 220 ggc acc aac ggg acc tgc ctg ctg gcc agc atg ggg ctg cag ctg aac 720 Gly Thr Asn Gly Thr Cys Leu Leu Ala Ser Met Gly Leu Gln Leu Asn 225 230 235 240 ctc acc tat gag agg aag gac aac acg acg gtg aca agg ctt ctc aac 768 Leu Thr Tyr Glu Arg Lys Asp Asn Thr Thr Val Thr Arg Leu Leu Asn 245 250 255 atc aac ccc aac aag acc tcg gcc agc ggg agc tgc ggc gcc cac ctg 816 Ile Asn Pro Asn Lys Thr Ser Ala Ser Gly Ser Cys Gly Ala His Leu 260 265 270 gtg act ctg gag ctg cac agc gag ggc acc acc gtc ctg ctc ttc cag 864 Val Thr Leu Glu Leu His Ser Glu Gly Thr Thr Val Leu Leu Phe Gln 275 280 285 ttc ggg atg aat gca agt tct agc cgg ttt ttc cta caa gga atc cag 912 Phe Gly Met Asn Ala Ser Ser Ser Arg Phe Phe Leu Gln Gly Ile Gln 290 295 300 ttg aat aca att ctt cct gac gcc aga gac cct gcc ttt aaa gct gcc 960 Leu Asn Thr Ile Leu Pro Asp Ala Arg Asp Pro Ala Phe Lys Ala Ala 305 310 315 320 aac ggc tcc ctg cga gcg ctg cag gcc aca gtc ggc aat tcc tac aag 1008 Asn Gly Ser Leu Arg Ala Leu Gln Ala Thr Val Gly Asn Ser Tyr Lys 325 330 335 tgc aac gcg gag gag cac gtc cgt gtc acg aag gcg ttt tca gtc aat 1056 Cys Asn Ala Glu Glu His Val Arg Val Thr Lys Ala Phe Ser Val Asn 340 345 350 ata ttc aaa gtg tgg gtc cag gct ttc aag gtg gaa ggt ggc cag ttt 1104 Ile Phe Lys Val Trp Val Gln Ala Phe Lys Val Glu Gly Gly Gln Phe 355 360 365 ggc tct gtg gag gag tgt ctg ctg gac gag aac agc ctc gag act aac 1152 Gly Ser Val Glu Glu Cys Leu Leu Asp Glu Asn Ser Leu Glu Thr Asn 370 375 380 gca tgc tcc att aac ggt aat gct ccc gcc gag att gat ctg cgc caa 1200 Ala Cys Ser Ile Asn Gly Asn Ala Pro Ala Glu Ile Asp Leu Arg Gln 385 390 395 400 atg aga acc gtt aca ccc ata agg tca gga gta gcc gct acg gaa tca 1248 Met Arg Thr Val Thr Pro Ile Arg Ser Gly Val Ala Ala Thr Glu Ser 405 410 415 gca tac ctg gct tac aga aac cag tct ctg gac ctt gca gaa cag gaa 1296 Ala Tyr Leu Ala Tyr Arg Asn Gln Ser Leu Asp Leu Ala Glu Gln Glu 420 425 430 ctg gtg gac tgc gca tca cag cac aac gga tgt cac ggg gac acc ata 1344 Leu Val Asp Cys Ala Ser Gln His Asn Gly Cys His Gly Asp Thr Ile 435 440 445 ccc aga ggg atc gag tat atc cag cac aat ggc gta gtg cag gaa agc 1392 Pro Arg Gly Ile Glu Tyr Ile Gln His Asn Gly Val Val Gln Glu Ser 450 455 460 tac tat agg tat gtc gcg cga gag caa agc tgt agg cgc cct aac gca 1440 Tyr Tyr Arg Tyr Val Ala Arg Glu Gln Ser Cys Arg Arg Pro Asn Ala 465 470 475 480 cag cgt ttc gga atc tcc aat tac tgc cag atc tat ccg caa aac gtt 1488 Gln Arg Phe Gly Ile Ser Asn Tyr Cys Gln Ile Tyr Pro Gln Asn Val 485 490 495 aac aaa atc cgt gaa gca ctg gcc caa acc cat agc gcc ata gct gtc 1536 Asn Lys Ile Arg Glu Ala Leu Ala Gln Thr His Ser Ala Ile Ala Val 500 505 510 atc atc ggt atc aaa gat ctg gat gcc ttt cgg cac tac gat gga agg 1584 Ile Ile Gly Ile Lys Asp Leu Asp Ala Phe Arg His Tyr Asp Gly Arg 515 520 525 act att ata cag cgc gac aat ggg tac cag ccc aat tat cac gca gtg 1632 Thr Ile Ile Gln Arg Asp Asn Gly Tyr Gln Pro Asn Tyr His Ala Val 530 535 540 aac att gtg gga tat agc aat gcg caa ggt gtc gat tac tgg atc gtc 1680 Asn Ile Val Gly Tyr Ser Asn Ala Gln Gly Val Asp Tyr Trp Ile Val 545 550 555 560 cgc aac tcc tgg gac aca aat tgg ggc gac aat ggc tat ggc tac ttt 1728 Arg Asn Ser Trp Asp Thr Asn Trp Gly Asp Asn Gly Tyr Gly Tyr Phe 565 570 575 gct gcc aat att gac ctc atg atg ata gag gag tat ccg tac gtc gtg 1776 Ala Ala Asn Ile Asp Leu Met Met Ile Glu Glu Tyr Pro Tyr Val Val 580 585 590 atc ctt ggc ggc ggc gga gat cag gta gac gtt aag gat tgc gct aac 1824 Ile Leu Gly Gly Gly Gly Asp Gln Val Asp Val Lys Asp Cys Ala Asn 595 600 605 cat gag atc aag aaa gtc ttg gtg cca ggc tgt cat ggc tct gag cct 1872 His Glu Ile Lys Lys Val Leu Val Pro Gly Cys His Gly Ser Glu Pro 610 615 620 tgc att atc cat cgc ggg aag cct ttt cag ctt gaa gcc gtc ttt gaa 1920 Cys Ile Ile His Arg Gly Lys Pro Phe Gln Leu Glu Ala Val Phe Glu 625 630 635 640 gcc aac cag aac acc aag acg gcc aaa atc gag atc aag gct agc att 1968 Ala Asn Gln Asn Thr Lys Thr Ala Lys Ile Glu Ile Lys Ala Ser Ile 645 650 655 gat ggg ctg gaa gtc gac gtt cca ggc att gac cca aac gcc tgt cac 2016 Asp Gly Leu Glu Val Asp Val Pro Gly Ile Asp Pro Asn Ala Cys His 660 665 670 tac atg aag tgc cct ctg gtg aaa ggg cag cag tac gac ata aag tac 2064 Tyr Met Lys Cys Pro Leu Val Lys Gly Gln Gln Tyr Asp Ile Lys Tyr 675 680 685 acc tgg aat gtg cct aaa atc gcc cca aaa tct gag aat gtg gtg gtt 2112 Thr Trp Asn Val Pro Lys Ile Ala Pro Lys Ser Glu Asn Val Val Val 690 695 700 aca gtg aaa gtg atg ggc gat gac gga gtt ttg gcc tgt gcc ata gca 2160 Thr Val Lys Val Met Gly Asp Asp Gly Val Leu Ala Cys Ala Ile Ala 705 710 715 720 acc cat gct aag att agg gac ggc ggt ggt ggg gcg aat gat aac gat 2208 Thr His Ala Lys Ile Arg Asp Gly Gly Gly Gly Ala Asn Asp Asn Asp 725 730 735 gac gac ccc aca act act gta cat cct acc acc aca gaa caa ccg gat 2256 Asp Asp Pro Thr Thr Thr Val His Pro Thr Thr Thr Glu Gln Pro Asp 740 745 750 gat aag ttt gaa tgc cca agc aga ttc ggt tat ttc gcg gat cca aag 2304 Asp Lys Phe Glu Cys Pro Ser Arg Phe Gly Tyr Phe Ala Asp Pro Lys 755 760 765 gat cct cac aag ttc tac att tgc tca aac tgg gag gca gtg cat aaa 2352 Asp Pro His Lys Phe Tyr Ile Cys Ser Asn Trp Glu Ala Val His Lys 770 775 780 gac tgt ccc ggc aat act cgg tgg aat gag gac gag gaa act tgt acc 2400 Asp Cys Pro Gly Asn Thr Arg Trp Asn Glu Asp Glu Glu Thr Cys Thr 785 790 795 800 ggc ggt gga gga gat cca atc cac tat gac aag ata aca gaa gaa atc 2448 Gly Gly Gly Gly Asp Pro Ile His Tyr Asp Lys Ile Thr Glu Glu Ile 805 810 815 aat aag gct gtg gat gag gct gtt gcc gcc atc gaa aag tcc gag aca 2496 Asn Lys Ala Val Asp Glu Ala Val Ala Ala Ile Glu Lys Ser Glu Thr 820 825 830 ttc gat ccc atg aaa gtc ccc gac cac agc gac aag ttt gaa cgg cac 2544 Phe Asp Pro Met Lys Val Pro Asp His Ser Asp Lys Phe Glu Arg His 835 840 845 att gga att atc gac ctg aaa ggg gaa ctc gac atg cgg aac att cag 2592 Ile Gly Ile Ile Asp Leu Lys Gly Glu Leu Asp Met Arg Asn Ile Gln 850 855 860 gtt aga ggc ctc aaa cag atg aaa cga gtt ggg gat gct aat gtg aag 2640 Val Arg Gly Leu Lys Gln Met Lys Arg Val Gly Asp Ala Asn Val Lys 865 870 875 880 agt gag gat ggg gtg gtg aag gca cat ctg ctc gta ggg gtc cat gac 2688 Ser Glu Asp Gly Val Val Lys Ala His Leu Leu Val Gly Val His Asp 885 890 895 gat gtg gtc agt atg gag tat gat ctg gcc tac aaa ctc ggt gat ttg 2736 Asp Val Val Ser Met Glu Tyr Asp Leu Ala Tyr Lys Leu Gly Asp Leu 900 905 910 cac ccc aat aca cac gta atc agt gac att cag gac ttt gtg gtg gag 2784 His Pro Asn Thr His Val Ile Ser Asp Ile Gln Asp Phe Val Val Glu 915 920 925 ctg tct ctg gaa gtt tcc gag gag gga aac atg acc ctg act tcc ttc 2832 Leu Ser Leu Glu Val Ser Glu Glu Gly Asn Met Thr Leu Thr Ser Phe 930 935 940 gag gtg cga cag ttc gca aac gtc gtg aat cac att gga ggc ctg tct 2880 Glu Val Arg Gln Phe Ala Asn Val Val Asn His Ile Gly Gly Leu Ser 945 950 955 960 att ctg gat cct atc ttt gcc gtg ttg agt gac gtg ctg aca gcg atc 2928 Ile Leu Asp Pro Ile Phe Ala Val Leu Ser Asp Val Leu Thr Ala Ile 965 970 975 ttc caa gac acg gtc aga gcc gag atg acc aaa gtg ctc gct cca gcc 2976 Phe Gln Asp Thr Val Arg Ala Glu Met Thr Lys Val Leu Ala Pro Ala 980 985 990 ttc aag aag gag ctt gag cgg aac aac cag gaa ttc acg ctg atc ccc 3024 Phe Lys Lys Glu Leu Glu Arg Asn Asn Gln Glu Phe Thr Leu Ile Pro 995 1000 1005 atc gct gtg ggt ggt gcc ctg gcg ggg ctg gtc ctc atc gtc ctc 3069 Ile Ala Val Gly Gly Ala Leu Ala Gly Leu Val Leu Ile Val Leu 1010 1015 1020 atc gcc tac ctc gtc ggc agg aag agg agt cac gca ggc tac cag 3114 Ile Ala Tyr Leu Val Gly Arg Lys Arg Ser His Ala Gly Tyr Gln 1025 1030 1035 act atc tag 3123 Thr Ile 1040 <210> 2 <211> 1040 <212> PRT <213> Secuencia artifical <220> <223> Constructo sintético <400> 2 Met Ala Pro Arg Ser Ala Arg Arg Pro Leu Leu Leu Leu Leu Leu Leu 1 5 10 15 Leu Leu Leu Gly Leu Met His Cys Ala Ser Ala Ala Met Phe Met Val 20 25 30 Lys Asn Gly Asn Gly Thr Ala Cys Ile Met Ala Asn Phe Ser Ala Ala 35 40 45 Phe Ser Val Asn Tyr Asp Thr Lys Ser Gly Pro Lys Asn Met Thr Leu 50 55 60 Asp Leu Pro Ser Asp Ala Thr Val Val Leu Asn Arg Ser Ser Cys Gly 65 70 75 80 Lys Glu Asn Thr Ser Asp Pro Ser Leu Val Ile Ala Phe Gly Arg Gly 85 90 95 His Thr Leu Thr Leu Asn Phe Thr Arg Asn Ala Thr Arg Tyr Ser Val 100 105 110 Gln Leu Met Ser Phe Val Tyr Asn Leu Ser Asp Thr His Leu Phe Pro 115 120 125 Asn Ala Ser Ser Lys Glu Ile Lys Thr Val Glu Ser Ile Thr Asp Ile 130 135 140 Arg Ala Asp Ile Asp Lys Lys Tyr Arg Cys Val Ser Gly Thr Gln Val 145 150 155 160 His Met Asn Asn Val Thr Val Thr Leu His Asp Ala Thr Ile Gln Ala 165 170 175 Tyr Leu Ser Asn Ser Ser Phe Ser Arg Gly Glu Thr Arg Cys Glu Gln 180 185 190 Asp Arg Pro Ser Pro Thr Thr Ala Pro Pro Ala Pro Pro Ser Pro Ser 195 200 205 Pro Ser Pro Val Pro Lys Ser Pro Ser Val Asp Lys Tyr Asn Val Ser 210 215 220 Gly Thr Asn Gly Thr Cys Leu Leu Ala Ser Met Gly Leu Gln Leu Asn 225 230 235 240 Leu Thr Tyr Glu Arg Lys Asp Asn Thr Thr Val Thr Arg Leu Leu Asn 245 250 255 Ile Asn Pro Asn Lys Thr Ser Ala Ser Gly Ser Cys Gly Ala His Leu 260 265 270 Val Thr Leu Glu Leu His Ser Glu Gly Thr Thr Val Leu Leu Phe Gln 275 280 285 Phe Gly Met Asn Ala Ser Ser Ser Arg Phe Phe Leu Gln Gly Ile Gln 290 295 300 Leu Asn Thr Ile Leu Pro Asp Ala Arg Asp Pro Ala Phe Lys Ala Ala 305 310 315 320 Asn Gly Ser Leu Arg Ala Leu Gln Ala Thr Val Gly Asn Ser Tyr Lys 325 330 335 Cys Asn Ala Glu Glu His Val Arg Val Thr Lys Ala Phe Ser Val Asn 340 345 350 Ile Phe Lys Val Trp Val Gln Ala Phe Lys Val Glu Gly Gly Gln Phe 355 360 365 Gly Ser Val Glu Glu Cys Leu Leu Asp Glu Asn Ser Leu Glu Thr Asn 370 375 380 Ala Cys Ser Ile Asn Gly Asn Ala Pro Ala Glu Ile Asp Leu Arg Gln 385 390 395 400 Met Arg Thr Val Thr Pro Ile Arg Ser Gly Val Ala Ala Thr Glu Ser 405 410 415 Ala Tyr Leu Ala Tyr Arg Asn Gln Ser Leu Asp Leu Ala Glu Gln Glu 420 425 430 Leu Val Asp Cys Ala Ser Gln His Asn Gly Cys His Gly Asp Thr Ile 435 440 445 Pro Arg Gly Ile Glu Tyr Ile Gln His Asn Gly Val Val Gln Glu Ser 450 455 460 Tyr Tyr Arg Tyr Val Ala Arg Glu Gln Ser Cys Arg Arg Pro Asn Ala 465 470 475 480 Gln Arg Phe Gly Ile Ser Asn Tyr Cys Gln Ile Tyr Pro Gln Asn Val 485 490 495 Asn Lys Ile Arg Glu Ala Leu Ala Gln Thr His Ser Ala Ile Ala Val 500 505 510 Ile Ile Gly Ile Lys Asp Leu Asp Ala Phe Arg His Tyr Asp Gly Arg 515 520 525 Thr Ile Ile Gln Arg Asp Asn Gly Tyr Gln Pro Asn Tyr His Ala Val 530 535 540 Asn Ile Val Gly Tyr Ser Asn Ala Gln Gly Val Asp Tyr Trp Ile Val 545 550 555 560 Arg Asn Ser Trp Asp Thr Asn Trp Gly Asp Asn Gly Tyr Gly Tyr Phe 565 570 575 Ala Ala Asn Ile Asp Leu Met Met Ile Glu Glu Tyr Pro Tyr Val Val 580 585 590 Ile Leu Gly Gly Gly Gly Asp Gln Val Asp Val Lys Asp Cys Ala Asn 595 600 605 His Glu Ile Lys Lys Val Leu Val Pro Gly Cys His Gly Ser Glu Pro 610 615 620 Cys Ile Ile His Arg Gly Lys Pro Phe Gln Leu Glu Ala Val Phe Glu 625 630 635 640 Ala Asn Gln Asn Thr Lys Thr Ala Lys Ile Glu Ile Lys Ala Ser Ile 645 650 655 Asp Gly Leu Glu Val Asp Val Pro Gly Ile Asp Pro Asn Ala Cys His 660 665 670 Tyr Met Lys Cys Pro Leu Val Lys Gly Gln Gln Tyr Asp Ile Lys Tyr 675 680 685 Thr Trp Asn Val Pro Lys Ile Ala Pro Lys Ser Glu Asn Val Val Val 690 695 700 Thr Val Lys Val Met Gly Asp Asp Gly Val Leu Ala Cys Ala Ile Ala 705 710 715 720 Thr His Ala Lys Ile Arg Asp Gly Gly Gly Gly Ala Asn Asp Asn Asp 725 730 735 Asp Asp Pro Thr Thr Thr Val His Pro Thr Thr Thr Glu Gln Pro Asp 740 745 750 Asp Lys Phe Glu Cys Pro Ser Arg Phe Gly Tyr Phe Ala Asp Pro Lys 755 760 765 Asp Pro His Lys Phe Tyr Ile Cys Ser Asn Trp Glu Ala Val His Lys 770 775 780 Asp Cys Pro Gly Asn Thr Arg Trp Asn Glu Asp Glu Glu Thr Cys Thr 785 790 795 800 Gly Gly Gly Gly Asp Pro Ile His Tyr Asp Lys Ile Thr Glu Glu Ile 805 810 815 Asn Lys Ala Val Asp Glu Ala Val Ala Ala Ile Glu Lys Ser Glu Thr 820 825 830 Phe Asp Pro Met Lys Val Pro Asp His Ser Asp Lys Phe Glu Arg His 835 840 845 Ile Gly Ile Ile Asp Leu Lys Gly Glu Leu Asp Met Arg Asn Ile Gln 850 855 860 Val Arg Gly Leu Lys Gln Met Lys Arg Val Gly Asp Ala Asn Val Lys 865 870 875 880 Ser Glu Asp Gly Val Val Lys Ala His Leu Leu Val Gly Val His Asp 885 890 895 Asp Val Val Ser Met Glu Tyr Asp Leu Ala Tyr Lys Leu Gly Asp Leu 900 905 910 His Pro Asn Thr His Val Ile Ser Asp Ile Gln Asp Phe Val Val Glu 915 920 925 Leu Ser Leu Glu Val Ser Glu Glu Gly Asn Met Thr Leu Thr Ser Phe 930 935 940 Glu Val Arg Gln Phe Ala Asn Val Val Asn His Ile Gly Gly Leu Ser 945 950 955 960 Ile Leu Asp Pro Ile Phe Ala Val Leu Ser Asp Val Leu Thr Ala Ile 965 970 975 Phe Gln Asp Thr Val Arg Ala Glu Met Thr Lys Val Leu Ala Pro Ala 980 985 990 Phe Lys Lys Glu Leu Glu Arg Asn Asn Gln Glu Phe Thr Leu Ile Pro 995 1000 1005 Ile Ala Val Gly Gly Ala Leu Ala Gly Leu Val Leu Ile Val Leu 1010 1015 1020 Ile Ala Tyr Leu Val Gly Arg Lys Arg Ser His Ala Gly Tyr Gln 1025 1030 1035 Thr Ile 1040 <210> 3 <211> 6127 <212> DNA <213> Secuencia artificial <220> <223> Un vector que comprende ácido nucleico que codifica una proteína quimérica <400> 3 ccgcctaatg agcgggcttt tttttcttag ggtgcaaaag gagagcctgt aagcgggcac 60 tcttccgtgg tctggtggat aaattcgcaa gggtatcatg gcggacgacc ggggttcgag 120 ccccgtatcc ggccgtccgc cgtgatccat gcggttaccg cccgcgtgtc gaacccaggt 180 gtgcgacgtc agacaacggg ggagtgctcc ttttggcttc cttccccttc ttccgcttcc 240 tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc gagcggtatc agctcactca 300 aaggcggtaa tacggttatc cacagaatca ggggataacg caggaaagaa catgtgagca 360 aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt tttccatagg 420 ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg gcgaaacccg 480 acaggactat aaagatacca ggcgtttccc cctggaagct ccctcgtgcg ctctcctgtt 540 ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc cttcgggaag cgtggcgctt 600 tctcatagct cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc caagctgggc 660 tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct tatccggtaa ctatcgtctt 720 gagtccaacc cggtaagaca cgacttatcg ccactggcag cagccactgg taacaggatt 780 agcagagcga ggtatgtagg cggtgctaca gagttcttga agtggtggcc taactacggc 840 tacactagaa gaacagtatt tggtatctgc gctctgctga agccagttac cttcggaaaa 900 agagttggta gctcttgatc cggcaaacaa accaccgctg gtagcggtgg tttttttgtt 960 tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag aagatccttt gatcttttct 1020 acggggtctg acgctcagtg gaacgaaaac tcacgttaag ggattttggt catgagatta 1080 tcaaaaagga tcttcaccta gatcctttta aattaaaaat gaagttttaa atcaatctaa 1140 agtatatatg agtaaacttg gtctgacagt taccaatgct taatcagtga ggcacctatc 1200 tcagcgatct gtctatttcg ttcatccata gttgcctgac tcctgcaaac cacgttgtgg 1260 tagaattggt aaagagagtc gtgtaaaata tcgagttcgc acatcttgtt gtctgattat 1320 tgatttttgg cgaaaccatt tgatcatatg acaagatgtg tatctacctt aacttaatga 1380 ttttgataaa aatcattagg taccccggct ctagatggca tgacattaac ctataaaaat 1440 aggcgtatca cgaggccctt tcgtctcgcg cgtttcggtg atgacggtga aaacctctga 1500 cacatgcagc tcccggagac ggtcacagct tgtctgtaag cggatgccgg gagcagacaa 1560 gcccgtcagg gcgcgtcagc gggtgttggc gggtgtcggg gctggcttaa ctatgcggca 1620 tcagagcaga ttgtactgag agtgcaccat atgcggtgtg aaataccgca cagatgcgta 1680 aggagaaaat accgcatcag attggctatt ggccattgca tacgttgtat ccatatcata 1740 atatgtacat ttatattggc tcatgtccaa cattaccgcc atgttgacat tgattattga 1800 ctagttatta atagtaatca attacggggt cattagttca tagcccatat atggagttcc 1860 gcgttacata acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat 1920 tgacgtcaat aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc 1980 aatgggtgga gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc 2040 caagtacgcc ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt 2100 acatgacctt atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta 2160 ccatggtgat gcggttttgg cagtacatca atgggcgtgg atagcggttt gactcacggg 2220 gatttccaag tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac 2280 gggactttcc aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg 2340 tacggtggga ggtctatata agcagagctc gtttagtgaa ccgtcagatc gcctggagac 2400 gccatccacg ctgttttgac ctccatagaa gacaccggga ccgatccagc ctccgcggct 2460 cgcatctctc cttcacgcgc ccgccgccct acctgaggcc gccatccacg ccggttgagt 2520 cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg cgtccgccgt ctaggtaagt 2580 ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc cttggagcct acctagactc 2640 agccggctct ccacgctttg cctgaccctg cttgctcaac tctagttctc tcgttaactt 2700 aatgagacag atagaaactg gtcttgtaga aacagagtag tcgcctgctt ttctgccagg 2760 tgctgacttc tctcccctgg gcttttttct ttttctcagg ttgaaaagaa gaagacgaag 2820 aagacgaaga agacaaaccg tcgtcgacat ggcgccccgc agcgcccggc gacccctgct 2880 gctgctactg ctgttgctgc tgctcggcct catgcattgt gcgtcagcag caatgtttat 2940 ggtgaaaaat ggcaacggga ccgcgtgcat aatggccaac ttctctgctg ccttctcagt 3000 gaactacgac accaagagtg gccctaagaa catgaccctt gacctgccat cagatgccac 3060 agtggtgctc aaccgcagct cctgtggaaa agagaacact tctgacccca gtctcgtgat 3120 tgcttttgga agaggacata cactcactct caatttcacg agaaatgcaa cacgttacag 3180 cgtccagctc atgagttttg tttataactt gtcagacaca caccttttcc ccaatgcgag 3240 ctccaaagaa atcaagactg tggaatctat aactgacatc agggcagata tagataaaaa 3300 atacagatgt gttagtggca cccaggtcca catgaacaac gtgaccgtaa cgctccatga 3360 tgccaccatc caggcgtacc tttccaacag cagcttcagc cggggagaga cacgctgtga 3420 acaagacagg ccttccccaa ccacagcgcc ccctgcgcca cccagcccct cgccctcacc 3480 cgtgcccaag agcccctctg tggacaagta caacgtgagc ggcaccaacg ggacctgcct 3540 gctggccagc atggggctgc agctgaacct cacctatgag aggaaggaca acacgacggt 3600 gacaaggctt ctcaacatca accccaacaa gacctcggcc agcgggagct gcggcgccca 3660 cctggtgact ctggagctgc acagcgaggg caccaccgtc ctgctcttcc agttcgggat 3720 gaatgcaagt tctagccggt ttttcctaca aggaatccag ttgaatacaa ttcttcctga 3780 cgccagagac cctgccttta aagctgccaa cggctccctg cgagcgctgc aggccacagt 3840 cggcaattcc tacaagtgca acgcggagga gcacgtccgt gtcacgaagg cgttttcagt 3900 caatatattc aaagtgtggg tccaggcttt caaggtggaa ggtggccagt ttggctctgt 3960 ggaggagtgt ctgctggacg agaacagcct cgagactaac gcatgctcca ttaacggtaa 4020 tgctcccgcc gagattgatc tgcgccaaat gagaaccgtt acacccataa ggtcaggagt 4080 agccgctacg gaatcagcat acctggctta cagaaaccag tctctggacc ttgcagaaca 4140 ggaactggtg gactgcgcat cacagcacaa cggatgtcac ggggacacca tacccagagg 4200 gatcgagtat atccagcaca atggcgtagt gcaggaaagc tactataggt atgtcgcgcg 4260 agagcaaagc tgtaggcgcc ctaacgcaca gcgtttcgga atctccaatt actgccagat 4320 ctatccgcaa aacgttaaca aaatccgtga agcactggcc caaacccata gcgccatagc 4380 tgtcatcatc ggtatcaaag atctggatgc ctttcggcac tacgatggaa ggactattat 4440 acagcgcgac aatgggtacc agcccaatta tcacgcagtg aacattgtgg gatatagcaa 4500 tgcgcaaggt gtcgattact ggatcgtccg caactcctgg gacacaaatt ggggcgacaa 4560 tggctatggc tactttgctg ccaatattga cctcatgatg atagaggagt atccgtacgt 4620 cgtgatcctt ggcggcggcg gagatcaggt agacgttaag gattgcgcta accatgagat 4680 caagaaagtc ttggtgccag gctgtcatgg ctctgagcct tgcattatcc atcgcgggaa 4740 gccttttcag cttgaagccg tctttgaagc caaccagaac accaagacgg ccaaaatcga 4800 gatcaaggct agcattgatg ggctggaagt cgacgttcca ggcattgacc caaacgcctg 4860 tcactacatg aagtgccctc tggtgaaagg gcagcagtac gacataaagt acacctggaa 4920 tgtgcctaaa atcgccccaa aatctgagaa tgtggtggtt acagtgaaag tgatgggcga 4980 tgacggagtt ttggcctgtg ccatagcaac ccatgctaag attagggacg gcggtggtgg 5040 ggcgaatgat aacgatgacg accccacaac tactgtacat cctaccacca cagaacaacc 5100 ggatgataag tttgaatgcc caagcagatt cggttatttc gcggatccaa aggatcctca 5160 caagttctac atttgctcaa actgggaggc agtgcataaa gactgtcccg gcaatactcg 5220 gtggaatgag gacgaggaaa cttgtaccgg cggtggagga gatccaatcc actatgacaa 5280 gataacagaa gaaatcaata aggctgtgga tgaggctgtt gccgccatcg aaaagtccga 5340 gacattcgat cccatgaaag tccccgacca cagcgacaag tttgaacggc acattggaat 5400 tatcgacctg aaaggggaac tcgacatgcg gaacattcag gttagaggcc tcaaacagat 5460 gaaacgagtt ggggatgcta atgtgaagag tgaggatggg gtggtgaagg cacatctgct 5520 cgtaggggtc catgacgatg tggtcagtat ggagtatgat ctggcctaca aactcggtga 5580 tttgcacccc aatacacacg taatcagtga cattcaggac tttgtggtgg agctgtctct 5640 ggaagtttcc gaggagggaa acatgaccct gacttccttc gaggtgcgac agttcgcaaa 5700 cgtcgtgaat cacattggag gcctgtctat tctggatcct atctttgccg tgttgagtga 5760 cgtgctgaca gcgatcttcc aagacacggt cagagccgag atgaccaaag tgctcgctcc 5820 agccttcaag aaggagcttg agcggaacaa ccaggaattc acgctgatcc ccatcgctgt 5880 gggtggtgcc ctggcggggc tggtcctcat cgtcctcatc gcctacctcg tcggcaggaa 5940 gaggagtcac gcaggctacc agactatcta gtaaggatct ttttccctct gccaaaaatt 6000 atggggacat catgaagccc cttgagcatc tgacttctgg ctaataaagg aaatttattt 6060 tcattgcaat agtgtgttgg aattttttgt gtctctcact cggaaggaca taagggcggc 6120 cgctagc 6127