LISTADO DE SECUENCIAS <110> ESTEVE PHARMACEUTICALS, S.A. Universitat Autňnoma de Barcelona <120> VECTORES DE VIRUS ADENOASOCIADOS PARA EL TRATAMIENTO DE MUCOPOLISACARIDOSIS TIPO IV A <130> AR2212.10 <150> EP18382373.1 <151> 2018-05-30 <160> 22 <170> PatentIn version 3.5 <210> 1 <211> 1577 <212> ADN <213> Homo sapiens <400> 1 tgccaccatg gcggcggttg tcgcggcgac gaggtggtgg cagctgttgc tggtgctcag 60 cgccgcgggg atgggggcct cgggcgcccc gcagcccccc aacatcctgc tcctgctcat 120 ggacgacatg ggatggggtg acctcggggt gtatggagag ccctccagag agaccccgaa 180 tttggaccgg atggctgcag aagggctgct tttcccaaac ttctattctg ccaaccctct 240 gtgctcgcca tcgagggcgg cactgctcac aggacggcta cccatccgca atggcttcta 300 caccaccaac gcccatgcca gaaacgccta cacaccgcag gagattgtgg gcggcatccc 360 agactcggag cagctcctgc cggagcttct gaagaaggcc ggctacgtca gcaagattgt 420 cggcaagtgg catctgggtc acaggcccca gttccacccc ctgaagcacg gatttgatga 480 gtggtttgga tcccccaact gccactttgg accttatgac aacaaggcca ggcccaacat 540 ccctgtgtac agggactggg agatggttgg cagatattat gaagaatttc ctattaatct 600 gaagacgggg gaagccaacc tcacccagat ctacctgcag gaagccctgg acttcattaa 660 gagacaggca cggcaccacc cctttttcct ctactgggct gtcgacgcca cgcacgcacc 720 cgtctatgcc tccaaaccct tcttgggcac cagtcagcga gggcggtatg gagacgccgt 780 ccgggagatt gatgacagca ttgggaagat actggagctc ctccaagacc tgcacgtcgc 840 ggacaacacc ttcgtcttct tcacgtcgga caacggcgct gccctcattt ccgcccccga 900 acaaggtggc agcaacggcc cctttctgtg tgggaagcag accacgtttg aaggagggat 960 gagggagcct gccctcgcat ggtggccagg gcacgtcact gcaggccagg tgagccacca 1020 gctgggcagc atcatggacc tcttcaccac cagcctggcc cttgcgggcc tgacgccgcc 1080 cagcgacagg gccattgatg gcctcaacct cctccccacc ctcctgcagg gccggctgat 1140 ggacaggcct atcttctatt accgtggcga cacgctgatg gcggccaccc tcgggcagca 1200 caaggctcac ttctggacct ggaccaactc ctgggagaac ttcagacagg gcattgattt 1260 ctgccctggg cagaacgttt caggggtcac aactcacaat ctggaagacc acacgaagct 1320 gcccctgatc ttccacctgg gacgggaccc aggggagagg ttccccctca gctttgccag 1380 cgccgagtac caggaggccc tcagcaggat cacctcggtc gtccagcagc accaggaggc 1440 cttggtcccc gcgcagcccc agctcaacgt gtgcaactgg gcggtcatga actgggcacc 1500 tccgggctgt gaaaagttag ggaagtgtct gacacctcca gaatccattc ccaagaagtg 1560 cctctggtcc cactagg 1577 <210> 2 <211> 7804 <212> ADN <213> Secuencia artificial <220> <223> pAAV-CAG-hGALNS <400> 2 gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt 60 tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca actccatcac 120 taggggttcc ttgtagttaa tgattaaccc gccatgctac ttatctactc gacattgatt 180 attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc catatatgga 240 gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca acgacccccg 300 cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga ctttccattg 360 acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc aagtgtatca 420 tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc 480 ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat tagtcatcgc 540 tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct cccccccctc 600 cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga tgggggcggg 660 gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg gcggggcgag 720 gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc cttttatggc 780 gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg gagtcgctgc 840 gttgccttcg ccccgtgccc cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac 900 tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg ggctgtaatt 960 agcgcttggt ttaatgacgg cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc 1020 tccgggaggg ccctttgtgc ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg 1080 tggggagcgc cgcgtgcggc tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg 1140 cggggctttg tgcgctccgc agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc 1200 ggtgcggggg gggctgcgag gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt 1260 gagcaggggg tgtgggcgcg tcggtcgggc tgcaaccccc cctgcacccc cctccccgag 1320 ttgctgagca cggcccggct tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg 1380 ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg 1440 ccggggaggg ctcgggggag gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg 1500 cggcgagccg cagccattgc cttttatggt aatcgtgcga gagggcgcag ggacttcctt 1560 tgtcccaaat ctgtgcggag ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc 1620 gcggggcgaa gcggtgcggc gccggcagga aggaaatggg cggggagggc cttcgtgcgt 1680 cgccgcgccg ccgtcccctt ctccctctcc agcctcgggg ctgtccgcgg ggggacggct 1740 gccttcgggg gggacggggc agggcggggt tcggcttctg gcgtgtgacc ggcggctcta 1800 gagcctctgc taaccatgtt catgccttct tctttttcct acagctcctg ggcaacgtgc 1860 tggttattgt gctgtctcat cattttggca aagaattgat taattcgagc gaacgcgtgc 1920 caccatggcg gcggttgtcg cggcgacgag gtggtggcag ctgttgctgg tgctcagcgc 1980 cgcggggatg ggggcctcgg gcgccccgca gccccccaac atcctgctcc tgctcatgga 2040 cgacatggga tggggtgacc tcggggtgta tggagagccc tccagagaga ccccgaattt 2100 ggaccggatg gctgcagaag ggctgctttt cccaaacttc tattctgcca accctctgtg 2160 ctcgccatcg agggcggcac tgctcacagg acggctaccc atccgcaatg gcttctacac 2220 caccaacgcc catgccagaa acgcctacac accgcaggag attgtgggcg gcatcccaga 2280 ctcggagcag ctcctgccgg agcttctgaa gaaggccggc tacgtcagca agattgtcgg 2340 caagtggcat ctgggtcaca ggccccagtt ccaccccctg aagcacggat ttgatgagtg 2400 gtttggatcc cccaactgcc actttggacc ttatgacaac aaggccaggc ccaacatccc 2460 tgtgtacagg gactgggaga tggttggcag atattatgaa gaatttccta ttaatctgaa 2520 gacgggggaa gccaacctca cccagatcta cctgcaggaa gccctggact tcattaagag 2580 acaggcacgg caccacccct ttttcctcta ctgggctgtc gacgccacgc acgcacccgt 2640 ctatgcctcc aaacccttct tgggcaccag tcagcgaggg cggtatggag acgccgtccg 2700 ggagattgat gacagcattg ggaagatact ggagctcctc caagacctgc acgtcgcgga 2760 caacaccttc gtcttcttca cgtcggacaa cggcgctgcc ctcatttccg cccccgaaca 2820 aggtggcagc aacggcccct ttctgtgtgg gaagcagacc acgtttgaag gagggatgag 2880 ggagcctgcc ctcgcatggt ggccagggca cgtcactgca ggccaggtga gccaccagct 2940 gggcagcatc atggacctct tcaccaccag cctggccctt gcgggcctga cgccgcccag 3000 cgacagggcc attgatggcc tcaacctcct ccccaccctc ctgcagggcc ggctgatgga 3060 caggcctatc ttctattacc gtggcgacac gctgatggcg gccaccctcg ggcagcacaa 3120 ggctcacttc tggacctgga ccaactcctg ggagaacttc agacagggca ttgatttctg 3180 ccctgggcag aacgtttcag gggtcacaac tcacaatctg gaagaccaca cgaagctgcc 3240 cctgatcttc cacctgggac gggacccagg ggagaggttc cccctcagct ttgccagcgc 3300 cgagtaccag gaggccctca gcaggatcac ctcggtcgtc cagcagcacc aggaggcctt 3360 ggtccccgcg cagccccagc tcaacgtgtg caactgggcg gtcatgaact gggcacctcc 3420 gggctgtgaa aagttaggga agtgtctgac acctccagaa tccattccca agaagtgcct 3480 ctggtcccac taggaattcg agctcggtac ccgggaatca attcactcct caggtgcagg 3540 ctgcctatca gaaggtggtg gctggtgtgg ccaatgccct ggctcacaaa taccactgag 3600 atctttttcc ctctgccaaa aattatgggg acatcatgaa gccccttgag catctgactt 3660 ctggctaata aaggaaattt attttcattg caatagtgtg ttggaatttt ttgtgtctct 3720 cactcggaag gacatatggg agggcaaatc atttaaaaca tcagaatgag tatttggttt 3780 agagtttggc aacatatgcc catatgctgg ctgccatgaa caaaggttgg ctataaagag 3840 gtcatcagta tatgaaacag ccccctgctg tccattcctt attccataga aaagccttga 3900 cttgaggtta gatttttttt atattttgtt ttgtgttatt tttttcttta acatccctaa 3960 aattttcctt acatgtttta ctagccagat ttttcctcct ctcctgacta ctcccagtca 4020 tagctgtccc tcttctctta tggagatccc tcgacctgca gcccaagctg tagataagta 4080 gcatggcggg ttaatcatta actacaagga acccctagtg atggagttgg ccactccctc 4140 tctgcgcgct cgctcgctca ctgaggccgc ccgggctttg cccgggcggc ctcagtgagc 4200 gagcgagcgc gcagctgcat taatgaatcg gccaacgcgc ggggagaggc ggtttgcgta 4260 ttgggcgctc ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc 4320 gagcggtatc agctcactca aaggcggtaa tacggttatc cacagaatca ggggataacg 4380 caggaaagaa catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt 4440 tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa 4500 gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct 4560 ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc 4620 cttcgggaag cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg 4680 tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct 4740 tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag 4800 cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga 4860 agtggtggcc taactacggc tacactagaa gaacagtatt tggtatctgc gctctgctga 4920 agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg 4980 gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag 5040 aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag 5100 ggattttggt catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat 5160 gaagttttaa atcaatctaa agtatatatg agtaaacttg gtctgacagt taccaatgct 5220 taatcagtga ggcacctatc tcagcgatct gtctatttcg ttcatccata gttgcctgac 5280 tccccgtcgt gtagataact acgatacggg agggcttacc atctggcccc agtgctgcaa 5340 tgataccgcg agacccacgc tcaccggctc cagatttatc agcaataaac cagccagccg 5400 gaagggccga gcgcagaagt ggtcctgcaa ctttatccgc ctccatccag tctattaatt 5460 gttgccggga agctagagta agtagttcgc cagttaatag tttgcgcaac gttgttgcca 5520 ttgctacagg catcgtggtg tcacgctcgt cgtttggtat ggcttcattc agctccggtt 5580 cccaacgatc aaggcgagtt acatgatccc ccatgttgtg caaaaaagcg gttagctcct 5640 tcggtcctcc gatcgttgtc agaagtaagt tggccgcagt gttatcactc atggttatgg 5700 cagcactgca taattctctt actgtcatgc catccgtaag atgcttttct gtgactggtg 5760 agtactcaac caagtcattc tgagaatagt gtatgcggcg accgagttgc tcttgcccgg 5820 cgtcaatacg ggataatacc gcgccacata gcagaacttt aaaagtgctc atcattggaa 5880 aacgttcttc ggggcgaaaa ctctcaagga tcttaccgct gttgagatcc agttcgatgt 5940 aacccactcg tgcacccaac tgatcttcag catcttttac tttcaccagc gtttctgggt 6000 gagcaaaaac aggaaggcaa aatgccgcaa aaaagggaat aagggcgaca cggaaatgtt 6060 gaatactcat actcttcctt tttcaatatt attgaagcat ttatcagggt tattgtctca 6120 tgagcggata catatttgaa tgtatttaga aaaataaaca aataggggtt ccgcgcacat 6180 ttccccgaaa agtgccacct gacgtctaag aaaccattat tatcatgaca ttaacctata 6240 aaaataggcg tatcacgagg ccctttcgtc tcgcgcgttt cggtgatgac ggtgaaaacc 6300 tctgacacat gcagctcccg gagacggtca cagcttgtct gtaagcggat gccgggagca 6360 gacaagcccg tcagggcgcg tcagcgggtg ttggcgggtg tcggggctgg cttaactatg 6420 cggcatcaga gcagattgta ctgagagtgc accatatgcg gtgtgaaata ccgcacagat 6480 gcgtaaggag aaaataccgc atcaggcgat tccaacatcc aataaatcat acaggcaagg 6540 caaagaatta gcaaaattaa gcaataaagc ctcagagcat aaagctaaat cggttgtacc 6600 aaaaacatta tgaccctgta atacttttgc gggagaagcc tttatttcaa cgcaaggata 6660 aaaattttta gaaccctcat atattttaaa tgcaatgcct gagtaatgtg taggtaaaga 6720 ttcaaacggg tgagaaaggc cggagacagt caaatcacca tcaatatgat attcaaccgt 6780 tctagctgat aaattcatgc cggagagggt agctattttt gagaggtctc tacaaaggct 6840 atcaggtcat tgcctgagag tctggagcaa acaagagaat cgatgaacgg taatcgtaaa 6900 actagcatgt caatcatatg taccccggtt gataatcaga aaagccccaa aaacaggaag 6960 attgtataag caaatattta aattgtaagc gttaatattt tgttaaaatt cgcgttaaat 7020 ttttgttaaa tcagctcatt ttttaaccaa taggccgaaa tcggcaaaat cccttataaa 7080 tcaaaagaat agaccgagat agggttgagt gttgttccag tttggaacaa gagtccacta 7140 ttaaagaacg tggactccaa cgtcaaaggg cgaaaaaccg tctatcaggg cgatggccca 7200 ctacgtgaac catcacccta atcaagtttt ttggggtcga ggtgccgtaa agcactaaat 7260 cggaacccta aagggagccc ccgatttaga gcttgacggg gaaagccggc gaacgtggcg 7320 agaaaggaag ggaagaaagc gaaaggagcg ggcgctaggg cgctggcaag tgtagcggtc 7380 acgctgcgcg taaccaccac acccgccgcg cttaatgcgc cgctacaggg cgcgtactat 7440 ggttgctttg acgagcacgt ataacgtgct ttcctcgtta gaatcagagc gggagctaaa 7500 caggaggccg attaaaggga ttttagacag gaacggtacg ccagaatcct gagaagtgtt 7560 tttataatca gtgaggccac cgagtaaaag agtctgtcca tcacgcaaat taaccgttgt 7620 cgcaatactt ctttgattag taataacatc acttgcctga gtagaagaac tcaaactatc 7680 ggccttgctg gtaatatcca gaacaatatt accgccagcc attgcaacgg aatcgccatt 7740 cgccattcag gctgcgcaac tgttgggaag ggcgatcggt gcgggcctct tcgctattac 7800 gcca 7804 <210> 3 <211> 1577 <212> ADN <213> Secuencia artificial <220> <223> CDS ohGALNS-versión1 <400> 3 tgccaccatg gctgctgtgg tggctgccac aagatggtgg cagctgctgc tggtgctgag 60 cgccgctgga atgggagctt ctggcgctcc ccagcccccc aatattctcc tgctgctgat 120 ggacgacatg ggctggggcg atctgggagt gtacggcgag cctagcagag agacacccaa 180 cctggacaga atggccgccg agggcctgct gttccccaac ttctacagcg ccaaccccct 240 gtgcagccca tctagagccg ctctgctgac cggcagactg cccatcagaa acggcttcta 300 caccaccaac gcccacgccc ggaacgccta cacaccccag gaaatcgtgg gcggcatccc 360 cgatagcgaa cagctgctgc ctgagctgct gaagaaagcc ggctacgtgt ccaagatcgt 420 gggcaagtgg cacctgggcc acagacccca gttccaccct ctgaagcacg gcttcgacga 480 gtggttcggc agccccaatt gccacttcgg cccctacgac aacaaggcca gacccaacat 540 ccccgtgtac cgggactggg agatggtggg acggtactac gaagagttcc ccatcaacct 600 gaaaaccggc gaggccaacc tgacccagat ctacctgcag gaagccctgg acttcatcaa 660 gcggcaggcc cggcaccacc ctttctttct gtactgggcc gtggacgcca cccacgcccc 720 tgtgtatgcc agcaagcctt tcctgggcac cagccagaga ggcagatacg gcgacgccgt 780 gcgcgagatc gatgacagca tcggcaagat cctggaactg ctgcaggacc tgcacgtggc 840 cgacaacacc ttcgtgttct tcaccagcga caacggcgct gccctgatct ctgctcctga 900 gcagggcggc agcaacggcc catttctgtg tggcaagcag accaccttcg agggcggcat 960 gagagaacct gccctggctt ggtggcctgg ccatgtgaca gctggacagg tgtcccacca 1020 gctgggcagc atcatggacc tgttcaccac cagcctggcc ctggccggac tgacacctcc 1080 aagcgacaga gccatcgacg gcctgaacct gctgcctacc ctgctgcagg gacggctgat 1140 ggaccggccc atcttctact acagaggcga caccctgatg gccgccacac tgggacagca 1200 caaggcccac ttttggacct ggaccaacag ctgggagaac ttccggcagg gcatcgactt 1260 ttgccctggc cagaatgtgt ccggcgtgac cacccacaac ctggaagatc acaccaagct 1320 gcccctgatt ttccacctgg gcagagatcc cggcgagcgg ttccctctgt cttttgccag 1380 cgccgagtac caggaagctc tgagcagaat cacctccgtg gtgcagcagc accaggaagc 1440 actggtgcct gctcagcccc agctgaacgt gtgcaattgg gccgtgatga actgggcccc 1500 tcccggctgt gaaaagctgg gaaagtgcct gaccccccct gagagcatcc ccaagaaatg 1560 cctgtggtcc cactgag 1577 <210> 4 <211> 7804 <212> ADN <213> Secuencia artificial <220> <223> pAAV-CAG-ohGALNSversión1 <400> 4 gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt 60 tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca actccatcac 120 taggggttcc ttgtagttaa tgattaaccc gccatgctac ttatctactc gacattgatt 180 attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc catatatgga 240 gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca acgacccccg 300 cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga ctttccattg 360 acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc aagtgtatca 420 tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc 480 ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat tagtcatcgc 540 tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct cccccccctc 600 cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga tgggggcggg 660 gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg gcggggcgag 720 gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc cttttatggc 780 gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg gagtcgctgc 840 gttgccttcg ccccgtgccc cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac 900 tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg ggctgtaatt 960 agcgcttggt ttaatgacgg cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc 1020 tccgggaggg ccctttgtgc ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg 1080 tggggagcgc cgcgtgcggc tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg 1140 cggggctttg tgcgctccgc agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc 1200 ggtgcggggg gggctgcgag gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt 1260 gagcaggggg tgtgggcgcg tcggtcgggc tgcaaccccc cctgcacccc cctccccgag 1320 ttgctgagca cggcccggct tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg 1380 ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg 1440 ccggggaggg ctcgggggag gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg 1500 cggcgagccg cagccattgc cttttatggt aatcgtgcga gagggcgcag ggacttcctt 1560 tgtcccaaat ctgtgcggag ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc 1620 gcggggcgaa gcggtgcggc gccggcagga aggaaatggg cggggagggc cttcgtgcgt 1680 cgccgcgccg ccgtcccctt ctccctctcc agcctcgggg ctgtccgcgg ggggacggct 1740 gccttcgggg gggacggggc agggcggggt tcggcttctg gcgtgtgacc ggcggctcta 1800 gagcctctgc taaccatgtt catgccttct tctttttcct acagctcctg ggcaacgtgc 1860 tggttattgt gctgtctcat cattttggca aagaattgat taattcgagc gaacgcgtgc 1920 caccatggct gctgtggtgg ctgccacaag atggtggcag ctgctgctgg tgctgagcgc 1980 cgctggaatg ggagcttctg gcgctcccca gccccccaat attctcctgc tgctgatgga 2040 cgacatgggc tggggcgatc tgggagtgta cggcgagcct agcagagaga cacccaacct 2100 ggacagaatg gccgccgagg gcctgctgtt ccccaacttc tacagcgcca accccctgtg 2160 cagcccatct agagccgctc tgctgaccgg cagactgccc atcagaaacg gcttctacac 2220 caccaacgcc cacgcccgga acgcctacac accccaggaa atcgtgggcg gcatccccga 2280 tagcgaacag ctgctgcctg agctgctgaa gaaagccggc tacgtgtcca agatcgtggg 2340 caagtggcac ctgggccaca gaccccagtt ccaccctctg aagcacggct tcgacgagtg 2400 gttcggcagc cccaattgcc acttcggccc ctacgacaac aaggccagac ccaacatccc 2460 cgtgtaccgg gactgggaga tggtgggacg gtactacgaa gagttcccca tcaacctgaa 2520 aaccggcgag gccaacctga cccagatcta cctgcaggaa gccctggact tcatcaagcg 2580 gcaggcccgg caccaccctt tctttctgta ctgggccgtg gacgccaccc acgcccctgt 2640 gtatgccagc aagcctttcc tgggcaccag ccagagaggc agatacggcg acgccgtgcg 2700 cgagatcgat gacagcatcg gcaagatcct ggaactgctg caggacctgc acgtggccga 2760 caacaccttc gtgttcttca ccagcgacaa cggcgctgcc ctgatctctg ctcctgagca 2820 gggcggcagc aacggcccat ttctgtgtgg caagcagacc accttcgagg gcggcatgag 2880 agaacctgcc ctggcttggt ggcctggcca tgtgacagct ggacaggtgt cccaccagct 2940 gggcagcatc atggacctgt tcaccaccag cctggccctg gccggactga cacctccaag 3000 cgacagagcc atcgacggcc tgaacctgct gcctaccctg ctgcagggac ggctgatgga 3060 ccggcccatc ttctactaca gaggcgacac cctgatggcc gccacactgg gacagcacaa 3120 ggcccacttt tggacctgga ccaacagctg ggagaacttc cggcagggca tcgacttttg 3180 ccctggccag aatgtgtccg gcgtgaccac ccacaacctg gaagatcaca ccaagctgcc 3240 cctgattttc cacctgggca gagatcccgg cgagcggttc cctctgtctt ttgccagcgc 3300 cgagtaccag gaagctctga gcagaatcac ctccgtggtg cagcagcacc aggaagcact 3360 ggtgcctgct cagccccagc tgaacgtgtg caattgggcc gtgatgaact gggcccctcc 3420 cggctgtgaa aagctgggaa agtgcctgac cccccctgag agcatcccca agaaatgcct 3480 gtggtcccac tgagaattcg agctcggtac ccgggaatca attcactcct caggtgcagg 3540 ctgcctatca gaaggtggtg gctggtgtgg ccaatgccct ggctcacaaa taccactgag 3600 atctttttcc ctctgccaaa aattatgggg acatcatgaa gccccttgag catctgactt 3660 ctggctaata aaggaaattt attttcattg caatagtgtg ttggaatttt ttgtgtctct 3720 cactcggaag gacatatggg agggcaaatc atttaaaaca tcagaatgag tatttggttt 3780 agagtttggc aacatatgcc catatgctgg ctgccatgaa caaaggttgg ctataaagag 3840 gtcatcagta tatgaaacag ccccctgctg tccattcctt attccataga aaagccttga 3900 cttgaggtta gatttttttt atattttgtt ttgtgttatt tttttcttta acatccctaa 3960 aattttcctt acatgtttta ctagccagat ttttcctcct ctcctgacta ctcccagtca 4020 tagctgtccc tcttctctta tggagatccc tcgacctgca gcccaagctg tagataagta 4080 gcatggcggg ttaatcatta actacaagga acccctagtg atggagttgg ccactccctc 4140 tctgcgcgct cgctcgctca ctgaggccgc ccgggctttg cccgggcggc ctcagtgagc 4200 gagcgagcgc gcagctgcat taatgaatcg gccaacgcgc ggggagaggc ggtttgcgta 4260 ttgggcgctc ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc 4320 gagcggtatc agctcactca aaggcggtaa tacggttatc cacagaatca ggggataacg 4380 caggaaagaa catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt 4440 tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa 4500 gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct 4560 ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc 4620 cttcgggaag cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg 4680 tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct 4740 tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag 4800 cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga 4860 agtggtggcc taactacggc tacactagaa gaacagtatt tggtatctgc gctctgctga 4920 agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg 4980 gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag 5040 aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag 5100 ggattttggt catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat 5160 gaagttttaa atcaatctaa agtatatatg agtaaacttg gtctgacagt taccaatgct 5220 taatcagtga ggcacctatc tcagcgatct gtctatttcg ttcatccata gttgcctgac 5280 tccccgtcgt gtagataact acgatacggg agggcttacc atctggcccc agtgctgcaa 5340 tgataccgcg agacccacgc tcaccggctc cagatttatc agcaataaac cagccagccg 5400 gaagggccga gcgcagaagt ggtcctgcaa ctttatccgc ctccatccag tctattaatt 5460 gttgccggga agctagagta agtagttcgc cagttaatag tttgcgcaac gttgttgcca 5520 ttgctacagg catcgtggtg tcacgctcgt cgtttggtat ggcttcattc agctccggtt 5580 cccaacgatc aaggcgagtt acatgatccc ccatgttgtg caaaaaagcg gttagctcct 5640 tcggtcctcc gatcgttgtc agaagtaagt tggccgcagt gttatcactc atggttatgg 5700 cagcactgca taattctctt actgtcatgc catccgtaag atgcttttct gtgactggtg 5760 agtactcaac caagtcattc tgagaatagt gtatgcggcg accgagttgc tcttgcccgg 5820 cgtcaatacg ggataatacc gcgccacata gcagaacttt aaaagtgctc atcattggaa 5880 aacgttcttc ggggcgaaaa ctctcaagga tcttaccgct gttgagatcc agttcgatgt 5940 aacccactcg tgcacccaac tgatcttcag catcttttac tttcaccagc gtttctgggt 6000 gagcaaaaac aggaaggcaa aatgccgcaa aaaagggaat aagggcgaca cggaaatgtt 6060 gaatactcat actcttcctt tttcaatatt attgaagcat ttatcagggt tattgtctca 6120 tgagcggata catatttgaa tgtatttaga aaaataaaca aataggggtt ccgcgcacat 6180 ttccccgaaa agtgccacct gacgtctaag aaaccattat tatcatgaca ttaacctata 6240 aaaataggcg tatcacgagg ccctttcgtc tcgcgcgttt cggtgatgac ggtgaaaacc 6300 tctgacacat gcagctcccg gagacggtca cagcttgtct gtaagcggat gccgggagca 6360 gacaagcccg tcagggcgcg tcagcgggtg ttggcgggtg tcggggctgg cttaactatg 6420 cggcatcaga gcagattgta ctgagagtgc accatatgcg gtgtgaaata ccgcacagat 6480 gcgtaaggag aaaataccgc atcaggcgat tccaacatcc aataaatcat acaggcaagg 6540 caaagaatta gcaaaattaa gcaataaagc ctcagagcat aaagctaaat cggttgtacc 6600 aaaaacatta tgaccctgta atacttttgc gggagaagcc tttatttcaa cgcaaggata 6660 aaaattttta gaaccctcat atattttaaa tgcaatgcct gagtaatgtg taggtaaaga 6720 ttcaaacggg tgagaaaggc cggagacagt caaatcacca tcaatatgat attcaaccgt 6780 tctagctgat aaattcatgc cggagagggt agctattttt gagaggtctc tacaaaggct 6840 atcaggtcat tgcctgagag tctggagcaa acaagagaat cgatgaacgg taatcgtaaa 6900 actagcatgt caatcatatg taccccggtt gataatcaga aaagccccaa aaacaggaag 6960 attgtataag caaatattta aattgtaagc gttaatattt tgttaaaatt cgcgttaaat 7020 ttttgttaaa tcagctcatt ttttaaccaa taggccgaaa tcggcaaaat cccttataaa 7080 tcaaaagaat agaccgagat agggttgagt gttgttccag tttggaacaa gagtccacta 7140 ttaaagaacg tggactccaa cgtcaaaggg cgaaaaaccg tctatcaggg cgatggccca 7200 ctacgtgaac catcacccta atcaagtttt ttggggtcga ggtgccgtaa agcactaaat 7260 cggaacccta aagggagccc ccgatttaga gcttgacggg gaaagccggc gaacgtggcg 7320 agaaaggaag ggaagaaagc gaaaggagcg ggcgctaggg cgctggcaag tgtagcggtc 7380 acgctgcgcg taaccaccac acccgccgcg cttaatgcgc cgctacaggg cgcgtactat 7440 ggttgctttg acgagcacgt ataacgtgct ttcctcgtta gaatcagagc gggagctaaa 7500 caggaggccg attaaaggga ttttagacag gaacggtacg ccagaatcct gagaagtgtt 7560 tttataatca gtgaggccac cgagtaaaag agtctgtcca tcacgcaaat taaccgttgt 7620 cgcaatactt ctttgattag taataacatc acttgcctga gtagaagaac tcaaactatc 7680 ggccttgctg gtaatatcca gaacaatatt accgccagcc attgcaacgg aatcgccatt 7740 cgccattcag gctgcgcaac tgttgggaag ggcgatcggt gcgggcctct tcgctattac 7800 gcca 7804 <210> 5 <211> 1577 <212> ADN <213> Secuencia artificial <220> <223> CDS ohGALNS-versión2 <400> 5 tgccaccatg gccgccgtgg tcgccgcaac tcgatggtgg cagctgctgc tggtcctgtc 60 cgccgctggc atgggagcct ctggagcccc tcagccccct aacatcctgc tgctgctgat 120 ggacgatatg ggatggggcg acctgggcgt gtacggagag ccaagccggg agacacccaa 180 tctggatagg atggcagcag agggcctgct gttcccaaac ttttattccg ccaatcctct 240 gtgcagccca tcccgcgccg ccctgctgac cggccggctg cccatcagaa acggcttcta 300 caccacaaac gcccacgccc ggaatgccta tacacctcag gagatcgtgg gcggcatccc 360 cgactctgag cagctgctgc ctgagctgct gaagaaggcc ggctacgtga gcaagatcgt 420 gggcaagtgg cacctgggac acaggccaca gttccaccct ctgaagcacg gcttcgatga 480 gtggtttggc agccccaatt gtcactttgg cccttacgac aacaaggcca gacccaatat 540 ccccgtgtac agagattggg agatggtggg caggtactat gaggagttcc ctatcaacct 600 gaagaccggc gaggccaatc tgacacagat ctacctgcag gaggccctgg actttatcaa 660 gaggcaggcc cgccaccacc ccttctttct gtactgggca gtggatgcaa cccacgcacc 720 agtgtatgcc tctaagccct tcctgggcac aagccagagg ggcagatatg gcgacgccgt 780 gagagagatc gacgattcta tcggcaagat cctggagctg ctgcaggacc tgcacgtggc 840 cgataacacc ttcgtgttct tcacatccga taatggagcc gccctgatct ccgccccaga 900 gcagggagga tctaacggac ccttcctgtg cggcaagcag accacatttg agggaggaat 960 gagggagcct gccctggcat ggtggccagg ccacgtgacc gccggccagg tgagccacca 1020 gctgggctcc atcatggacc tgttcaccac aagcctggcc ctggcaggcc tgaccccacc 1080 atccgacaga gccatcgatg gcctgaatct gctgcctaca ctgctgcagg gcaggctgat 1140 ggaccgccca atcttctact ataggggcga taccctgatg gcagccacac tgggacagca 1200 caaggcacac ttttggacct ggacaaactc ctgggagaat ttccgccagg gcatcgattt 1260 ttgtccaggc cagaacgtgt ctggcgtgac cacacacaat ctggaggacc acaccaagct 1320 gcccctgatc tttcacctgg gccgggatcc tggcgagaga ttcccactgt cttttgccag 1380 cgccgagtac caggaggccc tgtcccggat cacatctgtg gtgcagcagc accaggaggc 1440 cctggtgcca gcacagcccc agctgaacgt gtgcaattgg gccgtgatga actgggcccc 1500 tccaggctgt gagaaactgg gcaaatgtct gactccccct gaatctatcc ctaagaagtg 1560 tctgtggtcc cattagg 1577 <210> 6 <211> 7804 <212> ADN <213> Secuencia artificial <220> <223> pAAV-CAG-ohGALNS-versión2 <400> 6 gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt 60 tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca actccatcac 120 taggggttcc ttgtagttaa tgattaaccc gccatgctac ttatctactc gacattgatt 180 attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc catatatgga 240 gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca acgacccccg 300 cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga ctttccattg 360 acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc aagtgtatca 420 tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc 480 ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat tagtcatcgc 540 tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct cccccccctc 600 cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga tgggggcggg 660 gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg gcggggcgag 720 gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc cttttatggc 780 gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg gagtcgctgc 840 gttgccttcg ccccgtgccc cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac 900 tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg ggctgtaatt 960 agcgcttggt ttaatgacgg cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc 1020 tccgggaggg ccctttgtgc ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg 1080 tggggagcgc cgcgtgcggc tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg 1140 cggggctttg tgcgctccgc agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc 1200 ggtgcggggg gggctgcgag gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt 1260 gagcaggggg tgtgggcgcg tcggtcgggc tgcaaccccc cctgcacccc cctccccgag 1320 ttgctgagca cggcccggct tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg 1380 ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg 1440 ccggggaggg ctcgggggag gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg 1500 cggcgagccg cagccattgc cttttatggt aatcgtgcga gagggcgcag ggacttcctt 1560 tgtcccaaat ctgtgcggag ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc 1620 gcggggcgaa gcggtgcggc gccggcagga aggaaatggg cggggagggc cttcgtgcgt 1680 cgccgcgccg ccgtcccctt ctccctctcc agcctcgggg ctgtccgcgg ggggacggct 1740 gccttcgggg gggacggggc agggcggggt tcggcttctg gcgtgtgacc ggcggctcta 1800 gagcctctgc taaccatgtt catgccttct tctttttcct acagctcctg ggcaacgtgc 1860 tggttattgt gctgtctcat cattttggca aagaattgat taattcgagc gaacgcgtgc 1920 caccatggcc gccgtggtcg ccgcaactcg atggtggcag ctgctgctgg tcctgtccgc 1980 cgctggcatg ggagcctctg gagcccctca gccccctaac atcctgctgc tgctgatgga 2040 cgatatggga tggggcgacc tgggcgtgta cggagagcca agccgggaga cacccaatct 2100 ggataggatg gcagcagagg gcctgctgtt cccaaacttt tattccgcca atcctctgtg 2160 cagcccatcc cgcgccgccc tgctgaccgg ccggctgccc atcagaaacg gcttctacac 2220 cacaaacgcc cacgcccgga atgcctatac acctcaggag atcgtgggcg gcatccccga 2280 ctctgagcag ctgctgcctg agctgctgaa gaaggccggc tacgtgagca agatcgtggg 2340 caagtggcac ctgggacaca ggccacagtt ccaccctctg aagcacggct tcgatgagtg 2400 gtttggcagc cccaattgtc actttggccc ttacgacaac aaggccagac ccaatatccc 2460 cgtgtacaga gattgggaga tggtgggcag gtactatgag gagttcccta tcaacctgaa 2520 gaccggcgag gccaatctga cacagatcta cctgcaggag gccctggact ttatcaagag 2580 gcaggcccgc caccacccct tctttctgta ctgggcagtg gatgcaaccc acgcaccagt 2640 gtatgcctct aagcccttcc tgggcacaag ccagaggggc agatatggcg acgccgtgag 2700 agagatcgac gattctatcg gcaagatcct ggagctgctg caggacctgc acgtggccga 2760 taacaccttc gtgttcttca catccgataa tggagccgcc ctgatctccg ccccagagca 2820 gggaggatct aacggaccct tcctgtgcgg caagcagacc acatttgagg gaggaatgag 2880 ggagcctgcc ctggcatggt ggccaggcca cgtgaccgcc ggccaggtga gccaccagct 2940 gggctccatc atggacctgt tcaccacaag cctggccctg gcaggcctga ccccaccatc 3000 cgacagagcc atcgatggcc tgaatctgct gcctacactg ctgcagggca ggctgatgga 3060 ccgcccaatc ttctactata ggggcgatac cctgatggca gccacactgg gacagcacaa 3120 ggcacacttt tggacctgga caaactcctg ggagaatttc cgccagggca tcgatttttg 3180 tccaggccag aacgtgtctg gcgtgaccac acacaatctg gaggaccaca ccaagctgcc 3240 cctgatcttt cacctgggcc gggatcctgg cgagagattc ccactgtctt ttgccagcgc 3300 cgagtaccag gaggccctgt cccggatcac atctgtggtg cagcagcacc aggaggccct 3360 ggtgccagca cagccccagc tgaacgtgtg caattgggcc gtgatgaact gggcccctcc 3420 aggctgtgag aaactgggca aatgtctgac tccccctgaa tctatcccta agaagtgtct 3480 gtggtcccat taggaattcg agctcggtac ccgggaatca attcactcct caggtgcagg 3540 ctgcctatca gaaggtggtg gctggtgtgg ccaatgccct ggctcacaaa taccactgag 3600 atctttttcc ctctgccaaa aattatgggg acatcatgaa gccccttgag catctgactt 3660 ctggctaata aaggaaattt attttcattg caatagtgtg ttggaatttt ttgtgtctct 3720 cactcggaag gacatatggg agggcaaatc atttaaaaca tcagaatgag tatttggttt 3780 agagtttggc aacatatgcc catatgctgg ctgccatgaa caaaggttgg ctataaagag 3840 gtcatcagta tatgaaacag ccccctgctg tccattcctt attccataga aaagccttga 3900 cttgaggtta gatttttttt atattttgtt ttgtgttatt tttttcttta acatccctaa 3960 aattttcctt acatgtttta ctagccagat ttttcctcct ctcctgacta ctcccagtca 4020 tagctgtccc tcttctctta tggagatccc tcgacctgca gcccaagctg tagataagta 4080 gcatggcggg ttaatcatta actacaagga acccctagtg atggagttgg ccactccctc 4140 tctgcgcgct cgctcgctca ctgaggccgc ccgggctttg cccgggcggc ctcagtgagc 4200 gagcgagcgc gcagctgcat taatgaatcg gccaacgcgc ggggagaggc ggtttgcgta 4260 ttgggcgctc ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc 4320 gagcggtatc agctcactca aaggcggtaa tacggttatc cacagaatca ggggataacg 4380 caggaaagaa catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt 4440 tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa 4500 gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct 4560 ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc 4620 cttcgggaag cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg 4680 tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct 4740 tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag 4800 cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga 4860 agtggtggcc taactacggc tacactagaa gaacagtatt tggtatctgc gctctgctga 4920 agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg 4980 gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag 5040 aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag 5100 ggattttggt catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat 5160 gaagttttaa atcaatctaa agtatatatg agtaaacttg gtctgacagt taccaatgct 5220 taatcagtga ggcacctatc tcagcgatct gtctatttcg ttcatccata gttgcctgac 5280 tccccgtcgt gtagataact acgatacggg agggcttacc atctggcccc agtgctgcaa 5340 tgataccgcg agacccacgc tcaccggctc cagatttatc agcaataaac cagccagccg 5400 gaagggccga gcgcagaagt ggtcctgcaa ctttatccgc ctccatccag tctattaatt 5460 gttgccggga agctagagta agtagttcgc cagttaatag tttgcgcaac gttgttgcca 5520 ttgctacagg catcgtggtg tcacgctcgt cgtttggtat ggcttcattc agctccggtt 5580 cccaacgatc aaggcgagtt acatgatccc ccatgttgtg caaaaaagcg gttagctcct 5640 tcggtcctcc gatcgttgtc agaagtaagt tggccgcagt gttatcactc atggttatgg 5700 cagcactgca taattctctt actgtcatgc catccgtaag atgcttttct gtgactggtg 5760 agtactcaac caagtcattc tgagaatagt gtatgcggcg accgagttgc tcttgcccgg 5820 cgtcaatacg ggataatacc gcgccacata gcagaacttt aaaagtgctc atcattggaa 5880 aacgttcttc ggggcgaaaa ctctcaagga tcttaccgct gttgagatcc agttcgatgt 5940 aacccactcg tgcacccaac tgatcttcag catcttttac tttcaccagc gtttctgggt 6000 gagcaaaaac aggaaggcaa aatgccgcaa aaaagggaat aagggcgaca cggaaatgtt 6060 gaatactcat actcttcctt tttcaatatt attgaagcat ttatcagggt tattgtctca 6120 tgagcggata catatttgaa tgtatttaga aaaataaaca aataggggtt ccgcgcacat 6180 ttccccgaaa agtgccacct gacgtctaag aaaccattat tatcatgaca ttaacctata 6240 aaaataggcg tatcacgagg ccctttcgtc tcgcgcgttt cggtgatgac ggtgaaaacc 6300 tctgacacat gcagctcccg gagacggtca cagcttgtct gtaagcggat gccgggagca 6360 gacaagcccg tcagggcgcg tcagcgggtg ttggcgggtg tcggggctgg cttaactatg 6420 cggcatcaga gcagattgta ctgagagtgc accatatgcg gtgtgaaata ccgcacagat 6480 gcgtaaggag aaaataccgc atcaggcgat tccaacatcc aataaatcat acaggcaagg 6540 caaagaatta gcaaaattaa gcaataaagc ctcagagcat aaagctaaat cggttgtacc 6600 aaaaacatta tgaccctgta atacttttgc gggagaagcc tttatttcaa cgcaaggata 6660 aaaattttta gaaccctcat atattttaaa tgcaatgcct gagtaatgtg taggtaaaga 6720 ttcaaacggg tgagaaaggc cggagacagt caaatcacca tcaatatgat attcaaccgt 6780 tctagctgat aaattcatgc cggagagggt agctattttt gagaggtctc tacaaaggct 6840 atcaggtcat tgcctgagag tctggagcaa acaagagaat cgatgaacgg taatcgtaaa 6900 actagcatgt caatcatatg taccccggtt gataatcaga aaagccccaa aaacaggaag 6960 attgtataag caaatattta aattgtaagc gttaatattt tgttaaaatt cgcgttaaat 7020 ttttgttaaa tcagctcatt ttttaaccaa taggccgaaa tcggcaaaat cccttataaa 7080 tcaaaagaat agaccgagat agggttgagt gttgttccag tttggaacaa gagtccacta 7140 ttaaagaacg tggactccaa cgtcaaaggg cgaaaaaccg tctatcaggg cgatggccca 7200 ctacgtgaac catcacccta atcaagtttt ttggggtcga ggtgccgtaa agcactaaat 7260 cggaacccta aagggagccc ccgatttaga gcttgacggg gaaagccggc gaacgtggcg 7320 agaaaggaag ggaagaaagc gaaaggagcg ggcgctaggg cgctggcaag tgtagcggtc 7380 acgctgcgcg taaccaccac acccgccgcg cttaatgcgc cgctacaggg cgcgtactat 7440 ggttgctttg acgagcacgt ataacgtgct ttcctcgtta gaatcagagc gggagctaaa 7500 caggaggccg attaaaggga ttttagacag gaacggtacg ccagaatcct gagaagtgtt 7560 tttataatca gtgaggccac cgagtaaaag agtctgtcca tcacgcaaat taaccgttgt 7620 cgcaatactt ctttgattag taataacatc acttgcctga gtagaagaac tcaaactatc 7680 ggccttgctg gtaatatcca gaacaatatt accgccagcc attgcaacgg aatcgccatt 7740 cgccattcag gctgcgcaac tgttgggaag ggcgatcggt gcgggcctct tcgctattac 7800 gcca 7804 <210> 7 <211> 1577 <212> ADN <213> Secuencia artificial <220> <223> CDS ohGALNS-versión3 <400> 7 tgccaccatg gcagcggtgg tggccgcgac cagatggtgg cagcttctcc tggtcctgtc 60 ggccgcggga atgggtgcct cgggcgcgcc gcagccccct aacattctgc tgctgctgat 120 ggacgatatg ggatggggcg acctgggggt gtacggagag ccttcacggg aaacccccaa 180 cctggaccgc atggcggctg aaggcctgct gttcccgaac ttttactccg cgaatccgct 240 gtgctcccct tcgcgcgccg ccctcctgac cggacggttg cctatccgca acggcttcta 300 cactactaac gcacacgcca ggaacgccta caccccgcaa gaaattgtgg gaggaatccc 360 ggattccgaa cagctgctgc cggaactgct gaagaaggcc ggctacgtgt cgaagatcgt 420 gggaaagtgg catcttggtc atcggcctca gttccacccg ctcaagcacg ggttcgatga 480 atggttcgga tcccccaact gccactttgg cccctacgac aacaaggctc ggcctaacat 540 tcccgtctac cgggactggg aaatggtcgg aagatactac gaggagttcc ccatcaacct 600 caagactggc gaagccaacc tgactcagat ctacctccaa gaggccctgg acttcatcaa 660 gcgccaggcc cggcaccacc cgttcttcct ctattgggcg gtggacgcca cccatgcccc 720 cgtgtacgca tcaaagccgt tccttggaac tagccagaga ggcagatacg gggatgccgt 780 gcgcgaaatt gatgactcca tcggaaagat cctggagctg ctccaggacc tccatgtcgc 840 cgacaatacc ttcgtgttct ttacttccga taacggcgcc gccttgatca gcgccccgga 900 gcagggaggc tccaacggcc cttttctctg tgggaaacag accaccttcg agggagggat 960 gcgggaaccg gctctggctt ggtggcccgg acacgtgacc gccggccaag tgtcgcacca 1020 gcttggctcc atcatggact tgttcaccac ctcactggcc ctcgcggggc tcaccccacc 1080 aagcgaccga gcgattgacg gtctgaactt gctccccact ctgctgcaag gaaggctgat 1140 ggaccggccc atcttctact atcggggcga taccttgatg gccgccaccc tgggacagca 1200 caaggcccac ttttggactt ggacaaactc ctgggagaac ttccgccaag ggatcgactt 1260 ctgccccggt caaaacgtgt ccggcgtgac cacccacaac ctggaggacc ataccaagct 1320 gccactgatt ttccaccttg gtcgggaccc aggagagaga ttcccactga gcttcgcctc 1380 cgccgaatat caggaagcac tgtcccggat cacgagcgtg gtgcagcagc atcaggaggc 1440 cctggtgccg gcgcagccgc agctcaatgt ctgcaactgg gctgtgatga actgggcacc 1500 ccctggctgc gaaaaactcg ggaagtgtct gactccacct gagagcatcc cgaagaagtg 1560 cctgtggagc cactagg 1577 <210> 8 <211> 7804 <212> ADN <213> Secuencia artificial <220> <223> pAAV-CAG-ohGALNS-versión3 <400> 8 gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt 60 tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca actccatcac 120 taggggttcc ttgtagttaa tgattaaccc gccatgctac ttatctactc gacattgatt 180 attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc catatatgga 240 gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca acgacccccg 300 cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga ctttccattg 360 acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc aagtgtatca 420 tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc 480 ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat tagtcatcgc 540 tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct cccccccctc 600 cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga tgggggcggg 660 gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg gcggggcgag 720 gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc cttttatggc 780 gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg gagtcgctgc 840 gttgccttcg ccccgtgccc cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac 900 tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg ggctgtaatt 960 agcgcttggt ttaatgacgg cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc 1020 tccgggaggg ccctttgtgc ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg 1080 tggggagcgc cgcgtgcggc tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg 1140 cggggctttg tgcgctccgc agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc 1200 ggtgcggggg gggctgcgag gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt 1260 gagcaggggg tgtgggcgcg tcggtcgggc tgcaaccccc cctgcacccc cctccccgag 1320 ttgctgagca cggcccggct tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg 1380 ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg 1440 ccggggaggg ctcgggggag gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg 1500 cggcgagccg cagccattgc cttttatggt aatcgtgcga gagggcgcag ggacttcctt 1560 tgtcccaaat ctgtgcggag ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc 1620 gcggggcgaa gcggtgcggc gccggcagga aggaaatggg cggggagggc cttcgtgcgt 1680 cgccgcgccg ccgtcccctt ctccctctcc agcctcgggg ctgtccgcgg ggggacggct 1740 gccttcgggg gggacggggc agggcggggt tcggcttctg gcgtgtgacc ggcggctcta 1800 gagcctctgc taaccatgtt catgccttct tctttttcct acagctcctg ggcaacgtgc 1860 tggttattgt gctgtctcat cattttggca aagaattgat taattcgagc gaacgcgtgc 1920 caccatggca gcggtggtgg ccgcgaccag atggtggcag cttctcctgg tcctgtcggc 1980 cgcgggaatg ggtgcctcgg gcgcgccgca gccccctaac attctgctgc tgctgatgga 2040 cgatatggga tggggcgacc tgggggtgta cggagagcct tcacgggaaa cccccaacct 2100 ggaccgcatg gcggctgaag gcctgctgtt cccgaacttt tactccgcga atccgctgtg 2160 ctccccttcg cgcgccgccc tcctgaccgg acggttgcct atccgcaacg gcttctacac 2220 tactaacgca cacgccagga acgcctacac cccgcaagaa attgtgggag gaatcccgga 2280 ttccgaacag ctgctgccgg aactgctgaa gaaggccggc tacgtgtcga agatcgtggg 2340 aaagtggcat cttggtcatc ggcctcagtt ccacccgctc aagcacgggt tcgatgaatg 2400 gttcggatcc cccaactgcc actttggccc ctacgacaac aaggctcggc ctaacattcc 2460 cgtctaccgg gactgggaaa tggtcggaag atactacgag gagttcccca tcaacctcaa 2520 gactggcgaa gccaacctga ctcagatcta cctccaagag gccctggact tcatcaagcg 2580 ccaggcccgg caccacccgt tcttcctcta ttgggcggtg gacgccaccc atgcccccgt 2640 gtacgcatca aagccgttcc ttggaactag ccagagaggc agatacgggg atgccgtgcg 2700 cgaaattgat gactccatcg gaaagatcct ggagctgctc caggacctcc atgtcgccga 2760 caataccttc gtgttcttta cttccgataa cggcgccgcc ttgatcagcg ccccggagca 2820 gggaggctcc aacggccctt ttctctgtgg gaaacagacc accttcgagg gagggatgcg 2880 ggaaccggct ctggcttggt ggcccggaca cgtgaccgcc ggccaagtgt cgcaccagct 2940 tggctccatc atggacttgt tcaccacctc actggccctc gcggggctca ccccaccaag 3000 cgaccgagcg attgacggtc tgaacttgct ccccactctg ctgcaaggaa ggctgatgga 3060 ccggcccatc ttctactatc ggggcgatac cttgatggcc gccaccctgg gacagcacaa 3120 ggcccacttt tggacttgga caaactcctg ggagaacttc cgccaaggga tcgacttctg 3180 ccccggtcaa aacgtgtccg gcgtgaccac ccacaacctg gaggaccata ccaagctgcc 3240 actgattttc caccttggtc gggacccagg agagagattc ccactgagct tcgcctccgc 3300 cgaatatcag gaagcactgt cccggatcac gagcgtggtg cagcagcatc aggaggccct 3360 ggtgccggcg cagccgcagc tcaatgtctg caactgggct gtgatgaact gggcaccccc 3420 tggctgcgaa aaactcggga agtgtctgac tccacctgag agcatcccga agaagtgcct 3480 gtggagccac taggaattcg agctcggtac ccgggaatca attcactcct caggtgcagg 3540 ctgcctatca gaaggtggtg gctggtgtgg ccaatgccct ggctcacaaa taccactgag 3600 atctttttcc ctctgccaaa aattatgggg acatcatgaa gccccttgag catctgactt 3660 ctggctaata aaggaaattt attttcattg caatagtgtg ttggaatttt ttgtgtctct 3720 cactcggaag gacatatggg agggcaaatc atttaaaaca tcagaatgag tatttggttt 3780 agagtttggc aacatatgcc catatgctgg ctgccatgaa caaaggttgg ctataaagag 3840 gtcatcagta tatgaaacag ccccctgctg tccattcctt attccataga aaagccttga 3900 cttgaggtta gatttttttt atattttgtt ttgtgttatt tttttcttta acatccctaa 3960 aattttcctt acatgtttta ctagccagat ttttcctcct ctcctgacta ctcccagtca 4020 tagctgtccc tcttctctta tggagatccc tcgacctgca gcccaagctg tagataagta 4080 gcatggcggg ttaatcatta actacaagga acccctagtg atggagttgg ccactccctc 4140 tctgcgcgct cgctcgctca ctgaggccgc ccgggctttg cccgggcggc ctcagtgagc 4200 gagcgagcgc gcagctgcat taatgaatcg gccaacgcgc ggggagaggc ggtttgcgta 4260 ttgggcgctc ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc 4320 gagcggtatc agctcactca aaggcggtaa tacggttatc cacagaatca ggggataacg 4380 caggaaagaa catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt 4440 tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa 4500 gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct 4560 ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc 4620 cttcgggaag cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg 4680 tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct 4740 tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag 4800 cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga 4860 agtggtggcc taactacggc tacactagaa gaacagtatt tggtatctgc gctctgctga 4920 agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg 4980 gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag 5040 aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag 5100 ggattttggt catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat 5160 gaagttttaa atcaatctaa agtatatatg agtaaacttg gtctgacagt taccaatgct 5220 taatcagtga ggcacctatc tcagcgatct gtctatttcg ttcatccata gttgcctgac 5280 tccccgtcgt gtagataact acgatacggg agggcttacc atctggcccc agtgctgcaa 5340 tgataccgcg agacccacgc tcaccggctc cagatttatc agcaataaac cagccagccg 5400 gaagggccga gcgcagaagt ggtcctgcaa ctttatccgc ctccatccag tctattaatt 5460 gttgccggga agctagagta agtagttcgc cagttaatag tttgcgcaac gttgttgcca 5520 ttgctacagg catcgtggtg tcacgctcgt cgtttggtat ggcttcattc agctccggtt 5580 cccaacgatc aaggcgagtt acatgatccc ccatgttgtg caaaaaagcg gttagctcct 5640 tcggtcctcc gatcgttgtc agaagtaagt tggccgcagt gttatcactc atggttatgg 5700 cagcactgca taattctctt actgtcatgc catccgtaag atgcttttct gtgactggtg 5760 agtactcaac caagtcattc tgagaatagt gtatgcggcg accgagttgc tcttgcccgg 5820 cgtcaatacg ggataatacc gcgccacata gcagaacttt aaaagtgctc atcattggaa 5880 aacgttcttc ggggcgaaaa ctctcaagga tcttaccgct gttgagatcc agttcgatgt 5940 aacccactcg tgcacccaac tgatcttcag catcttttac tttcaccagc gtttctgggt 6000 gagcaaaaac aggaaggcaa aatgccgcaa aaaagggaat aagggcgaca cggaaatgtt 6060 gaatactcat actcttcctt tttcaatatt attgaagcat ttatcagggt tattgtctca 6120 tgagcggata catatttgaa tgtatttaga aaaataaaca aataggggtt ccgcgcacat 6180 ttccccgaaa agtgccacct gacgtctaag aaaccattat tatcatgaca ttaacctata 6240 aaaataggcg tatcacgagg ccctttcgtc tcgcgcgttt cggtgatgac ggtgaaaacc 6300 tctgacacat gcagctcccg gagacggtca cagcttgtct gtaagcggat gccgggagca 6360 gacaagcccg tcagggcgcg tcagcgggtg ttggcgggtg tcggggctgg cttaactatg 6420 cggcatcaga gcagattgta ctgagagtgc accatatgcg gtgtgaaata ccgcacagat 6480 gcgtaaggag aaaataccgc atcaggcgat tccaacatcc aataaatcat acaggcaagg 6540 caaagaatta gcaaaattaa gcaataaagc ctcagagcat aaagctaaat cggttgtacc 6600 aaaaacatta tgaccctgta atacttttgc gggagaagcc tttatttcaa cgcaaggata 6660 aaaattttta gaaccctcat atattttaaa tgcaatgcct gagtaatgtg taggtaaaga 6720 ttcaaacggg tgagaaaggc cggagacagt caaatcacca tcaatatgat attcaaccgt 6780 tctagctgat aaattcatgc cggagagggt agctattttt gagaggtctc tacaaaggct 6840 atcaggtcat tgcctgagag tctggagcaa acaagagaat cgatgaacgg taatcgtaaa 6900 actagcatgt caatcatatg taccccggtt gataatcaga aaagccccaa aaacaggaag 6960 attgtataag caaatattta aattgtaagc gttaatattt tgttaaaatt cgcgttaaat 7020 ttttgttaaa tcagctcatt ttttaaccaa taggccgaaa tcggcaaaat cccttataaa 7080 tcaaaagaat agaccgagat agggttgagt gttgttccag tttggaacaa gagtccacta 7140 ttaaagaacg tggactccaa cgtcaaaggg cgaaaaaccg tctatcaggg cgatggccca 7200 ctacgtgaac catcacccta atcaagtttt ttggggtcga ggtgccgtaa agcactaaat 7260 cggaacccta aagggagccc ccgatttaga gcttgacggg gaaagccggc gaacgtggcg 7320 agaaaggaag ggaagaaagc gaaaggagcg ggcgctaggg cgctggcaag tgtagcggtc 7380 acgctgcgcg taaccaccac acccgccgcg cttaatgcgc cgctacaggg cgcgtactat 7440 ggttgctttg acgagcacgt ataacgtgct ttcctcgtta gaatcagagc gggagctaaa 7500 caggaggccg attaaaggga ttttagacag gaacggtacg ccagaatcct gagaagtgtt 7560 tttataatca gtgaggccac cgagtaaaag agtctgtcca tcacgcaaat taaccgttgt 7620 cgcaatactt ctttgattag taataacatc acttgcctga gtagaagaac tcaaactatc 7680 ggccttgctg gtaatatcca gaacaatatt accgccagcc attgcaacgg aatcgccatt 7740 cgccattcag gctgcgcaac tgttgggaag ggcgatcggt gcgggcctct tcgctattac 7800 gcca 7804 <210> 9 <211> 1563 <212> ADN <213> Secuencia artificial <220> <223> CDS omGALNS <400> 9 atggctgctt gtacagccgc tcagcagctg ctgctggtgc tgtctgctct gggactgctg 60 gctgctggcg ctcctcagcc tcctaacatc gtgctgctgc tgatggacga catgggctgg 120 ggcgatctgg gagtgaacgg cgagcctagc agagagacac ccaacctgga cagaatggcc 180 gccgagggca tgctgttccc cagcttctac agcgccaacc ccctgtgcag cccttctaga 240 gccgctctgc tgaccggcag actgcccatc agaaacggct tctacaccac caacgcccac 300 gccagaaacg cctacacacc ccaggaaatc atgggcggca tccccaacag cgagcatctg 360 ctgcctgagc tgctgaagaa ggccggctac accaacaaga tcgtgggcaa gtggcacctg 420 ggccacagac cccagttcca ccctctgaag cacggcttcg acgagtggtt cggcagcccc 480 aactgtcact tcggccccta cgacaacaag gccaagccca acatccccgt gtacagagac 540 tgggagatgg tgggaagatt ctacgaagag ttccccatca acagaaagac cggcgaggcc 600 aacctgaccc agctgtacac acaggaagcc ctggacttca tccagaccca gcacgccaga 660 cagagcccct tcttcctgta ctgggccatc gacgccacac acgcccctgt gtacgccagc 720 agacagttcc tgggcaccag cctgagaggc agatatggcg acgccgtgcg cgagatcgac 780 gactctgtgg gcaagatcct gtccctgctg cagaacctgg gcatcagcaa gaacaccttc 840 gtgttcttca ccagcgacaa cggcgctgcc ctgatcagcg ctcctaatga gggcggcagc 900 aacggcccat tcctgtgcgg caagcagacc acattcgagg gcggaatgag agagcccgct 960 atcgcttggt ggcctggcca tatcgctgct ggccaggtgt cacaccagct gggcagcatc 1020 atggacctgt tcaccacctc cctgagcctg gccggactga agcctcctag cgacagagtg 1080 atcgacggcc tggacctgct gcccaccatg ctgaagggcc agatgatgga cagacccatc 1140 ttctactaca gaggcaacac cctgatggcc gtgaccctgg gccagtacaa ggcccacctg 1200 tggacctgga ccaacagctg ggaagagttt acccagggca ccgatttctg ccctggccag 1260 aatgtgtccg gcgtgaccac ccacacccag gaagaacaca ccgagctgcc cctgatcttc 1320 cacctgggaa gggaccccgg cgagagattc cctctgagct tccacagcga cgagtaccag 1380 gacgccctga gcagaaccac ccaggtggtg caggaacacc agaaaagcct ggtgcccggc 1440 cagccccagc tgaacgtgtg taaccaggcc gtgatgaact gggcccctcc cggatgtgaa 1500 aagctgggaa agtgcctgac cccccctgag agcgtgcccg agaagtgttt ctgggcccac 1560 tga 1563 <210> 10 <211> 7798 <212> ADN <213> Secuencia artificial <220> <223> pAAV-CAG-omGALNS <400> 10 gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt 60 tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca actccatcac 120 taggggttcc ttgtagttaa tgattaaccc gccatgctac ttatctactc gacattgatt 180 attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc catatatgga 240 gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca acgacccccg 300 cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga ctttccattg 360 acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc aagtgtatca 420 tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc 480 ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat tagtcatcgc 540 tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct cccccccctc 600 cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga tgggggcggg 660 gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg gcggggcgag 720 gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc cttttatggc 780 gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg gagtcgctgc 840 gttgccttcg ccccgtgccc cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac 900 tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg ggctgtaatt 960 agcgcttggt ttaatgacgg cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc 1020 tccgggaggg ccctttgtgc ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg 1080 tggggagcgc cgcgtgcggc tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg 1140 cggggctttg tgcgctccgc agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc 1200 ggtgcggggg gggctgcgag gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt 1260 gagcaggggg tgtgggcgcg tcggtcgggc tgcaaccccc cctgcacccc cctccccgag 1320 ttgctgagca cggcccggct tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg 1380 ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg 1440 ccggggaggg ctcgggggag gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg 1500 cggcgagccg cagccattgc cttttatggt aatcgtgcga gagggcgcag ggacttcctt 1560 tgtcccaaat ctgtgcggag ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc 1620 gcggggcgaa gcggtgcggc gccggcagga aggaaatggg cggggagggc cttcgtgcgt 1680 cgccgcgccg ccgtcccctt ctccctctcc agcctcgggg ctgtccgcgg ggggacggct 1740 gccttcgggg gggacggggc agggcggggt tcggcttctg gcgtgtgacc ggcggctcta 1800 gagcctctgc taaccatgtt catgccttct tctttttcct acagctcctg ggcaacgtgc 1860 tggttattgt gctgtctcat cattttggca aagaattgat taattcgagc gaacgcgtgc 1920 caccatggct gcttgtacag ccgctcagca gctgctgctg gtgctgtctg ctctgggact 1980 gctggctgct ggcgctcctc agcctcctaa catcgtgctg ctgctgatgg acgacatggg 2040 ctggggcgat ctgggagtga acggcgagcc tagcagagag acacccaacc tggacagaat 2100 ggccgccgag ggcatgctgt tccccagctt ctacagcgcc aaccccctgt gcagcccttc 2160 tagagccgct ctgctgaccg gcagactgcc catcagaaac ggcttctaca ccaccaacgc 2220 ccacgccaga aacgcctaca caccccagga aatcatgggc ggcatcccca acagcgagca 2280 tctgctgcct gagctgctga agaaggccgg ctacaccaac aagatcgtgg gcaagtggca 2340 cctgggccac agaccccagt tccaccctct gaagcacggc ttcgacgagt ggttcggcag 2400 ccccaactgt cacttcggcc cctacgacaa caaggccaag cccaacatcc ccgtgtacag 2460 agactgggag atggtgggaa gattctacga agagttcccc atcaacagaa agaccggcga 2520 ggccaacctg acccagctgt acacacagga agccctggac ttcatccaga cccagcacgc 2580 cagacagagc cccttcttcc tgtactgggc catcgacgcc acacacgccc ctgtgtacgc 2640 cagcagacag ttcctgggca ccagcctgag aggcagatat ggcgacgccg tgcgcgagat 2700 cgacgactct gtgggcaaga tcctgtccct gctgcagaac ctgggcatca gcaagaacac 2760 cttcgtgttc ttcaccagcg acaacggcgc tgccctgatc agcgctccta atgagggcgg 2820 cagcaacggc ccattcctgt gcggcaagca gaccacattc gagggcggaa tgagagagcc 2880 cgctatcgct tggtggcctg gccatatcgc tgctggccag gtgtcacacc agctgggcag 2940 catcatggac ctgttcacca cctccctgag cctggccgga ctgaagcctc ctagcgacag 3000 agtgatcgac ggcctggacc tgctgcccac catgctgaag ggccagatga tggacagacc 3060 catcttctac tacagaggca acaccctgat ggccgtgacc ctgggccagt acaaggccca 3120 cctgtggacc tggaccaaca gctgggaaga gtttacccag ggcaccgatt tctgccctgg 3180 ccagaatgtg tccggcgtga ccacccacac ccaggaagaa cacaccgagc tgcccctgat 3240 cttccacctg ggaagggacc ccggcgagag attccctctg agcttccaca gcgacgagta 3300 ccaggacgcc ctgagcagaa ccacccaggt ggtgcaggaa caccagaaaa gcctggtgcc 3360 cggccagccc cagctgaacg tgtgtaacca ggccgtgatg aactgggccc ctcccggatg 3420 tgaaaagctg ggaaagtgcc tgaccccccc tgagagcgtg cccgagaagt gtttctgggc 3480 ccactgagaa ttcgagctcg gtacccggga atcaattcac tcctcaggtg caggctgcct 3540 atcagaaggt ggtggctggt gtggccaatg ccctggctca caaataccac tgagatcttt 3600 ttccctctgc caaaaattat ggggacatca tgaagcccct tgagcatctg acttctggct 3660 aataaaggaa atttattttc attgcaatag tgtgttggaa ttttttgtgt ctctcactcg 3720 gaaggacata tgggagggca aatcatttaa aacatcagaa tgagtatttg gtttagagtt 3780 tggcaacata tgcccatatg ctggctgcca tgaacaaagg ttggctataa agaggtcatc 3840 agtatatgaa acagccccct gctgtccatt ccttattcca tagaaaagcc ttgacttgag 3900 gttagatttt ttttatattt tgttttgtgt tatttttttc tttaacatcc ctaaaatttt 3960 ccttacatgt tttactagcc agatttttcc tcctctcctg actactccca gtcatagctg 4020 tccctcttct cttatggaga tccctcgacc tgcagcccaa gctgtagata agtagcatgg 4080 cgggttaatc attaactaca aggaacccct agtgatggag ttggccactc cctctctgcg 4140 cgctcgctcg ctcactgagg ccgcccgggc tttgcccggg cggcctcagt gagcgagcga 4200 gcgcgcagct gcattaatga atcggccaac gcgcggggag aggcggtttg cgtattgggc 4260 gctcttccgc ttcctcgctc actgactcgc tgcgctcggt cgttcggctg cggcgagcgg 4320 tatcagctca ctcaaaggcg gtaatacggt tatccacaga atcaggggat aacgcaggaa 4380 agaacatgtg agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg 4440 cgtttttcca taggctccgc ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga 4500 ggtggcgaaa cccgacagga ctataaagat accaggcgtt tccccctgga agctccctcg 4560 tgcgctctcc tgttccgacc ctgccgctta ccggatacct gtccgccttt ctcccttcgg 4620 gaagcgtggc gctttctcat agctcacgct gtaggtatct cagttcggtg taggtcgttc 4680 gctccaagct gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc gccttatccg 4740 gtaactatcg tcttgagtcc aacccggtaa gacacgactt atcgccactg gcagcagcca 4800 ctggtaacag gattagcaga gcgaggtatg taggcggtgc tacagagttc ttgaagtggt 4860 ggcctaacta cggctacact agaagaacag tatttggtat ctgcgctctg ctgaagccag 4920 ttaccttcgg aaaaagagtt ggtagctctt gatccggcaa acaaaccacc gctggtagcg 4980 gtggtttttt tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct caagaagatc 5040 ctttgatctt ttctacgggg tctgacgctc agtggaacga aaactcacgt taagggattt 5100 tggtcatgag attatcaaaa aggatcttca cctagatcct tttaaattaa aaatgaagtt 5160 ttaaatcaat ctaaagtata tatgagtaaa cttggtctga cagttaccaa tgcttaatca 5220 gtgaggcacc tatctcagcg atctgtctat ttcgttcatc catagttgcc tgactccccg 5280 tcgtgtagat aactacgata cgggagggct taccatctgg ccccagtgct gcaatgatac 5340 cgcgagaccc acgctcaccg gctccagatt tatcagcaat aaaccagcca gccggaaggg 5400 ccgagcgcag aagtggtcct gcaactttat ccgcctccat ccagtctatt aattgttgcc 5460 gggaagctag agtaagtagt tcgccagtta atagtttgcg caacgttgtt gccattgcta 5520 caggcatcgt ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc ggttcccaac 5580 gatcaaggcg agttacatga tcccccatgt tgtgcaaaaa agcggttagc tccttcggtc 5640 ctccgatcgt tgtcagaagt aagttggccg cagtgttatc actcatggtt atggcagcac 5700 tgcataattc tcttactgtc atgccatccg taagatgctt ttctgtgact ggtgagtact 5760 caaccaagtc attctgagaa tagtgtatgc ggcgaccgag ttgctcttgc ccggcgtcaa 5820 tacgggataa taccgcgcca catagcagaa ctttaaaagt gctcatcatt ggaaaacgtt 5880 cttcggggcg aaaactctca aggatcttac cgctgttgag atccagttcg atgtaaccca 5940 ctcgtgcacc caactgatct tcagcatctt ttactttcac cagcgtttct gggtgagcaa 6000 aaacaggaag gcaaaatgcc gcaaaaaagg gaataagggc gacacggaaa tgttgaatac 6060 tcatactctt cctttttcaa tattattgaa gcatttatca gggttattgt ctcatgagcg 6120 gatacatatt tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc acatttcccc 6180 gaaaagtgcc acctgacgtc taagaaacca ttattatcat gacattaacc tataaaaata 6240 ggcgtatcac gaggcccttt cgtctcgcgc gtttcggtga tgacggtgaa aacctctgac 6300 acatgcagct cccggagacg gtcacagctt gtctgtaagc ggatgccggg agcagacaag 6360 cccgtcaggg cgcgtcagcg ggtgttggcg ggtgtcgggg ctggcttaac tatgcggcat 6420 cagagcagat tgtactgaga gtgcaccata tgcggtgtga aataccgcac agatgcgtaa 6480 ggagaaaata ccgcatcagg cgattccaac atccaataaa tcatacaggc aaggcaaaga 6540 attagcaaaa ttaagcaata aagcctcaga gcataaagct aaatcggttg taccaaaaac 6600 attatgaccc tgtaatactt ttgcgggaga agcctttatt tcaacgcaag gataaaaatt 6660 tttagaaccc tcatatattt taaatgcaat gcctgagtaa tgtgtaggta aagattcaaa 6720 cgggtgagaa aggccggaga cagtcaaatc accatcaata tgatattcaa ccgttctagc 6780 tgataaattc atgccggaga gggtagctat ttttgagagg tctctacaaa ggctatcagg 6840 tcattgcctg agagtctgga gcaaacaaga gaatcgatga acggtaatcg taaaactagc 6900 atgtcaatca tatgtacccc ggttgataat cagaaaagcc ccaaaaacag gaagattgta 6960 taagcaaata tttaaattgt aagcgttaat attttgttaa aattcgcgtt aaatttttgt 7020 taaatcagct cattttttaa ccaataggcc gaaatcggca aaatccctta taaatcaaaa 7080 gaatagaccg agatagggtt gagtgttgtt ccagtttgga acaagagtcc actattaaag 7140 aacgtggact ccaacgtcaa agggcgaaaa accgtctatc agggcgatgg cccactacgt 7200 gaaccatcac cctaatcaag ttttttgggg tcgaggtgcc gtaaagcact aaatcggaac 7260 cctaaaggga gcccccgatt tagagcttga cggggaaagc cggcgaacgt ggcgagaaag 7320 gaagggaaga aagcgaaagg agcgggcgct agggcgctgg caagtgtagc ggtcacgctg 7380 cgcgtaacca ccacacccgc cgcgcttaat gcgccgctac agggcgcgta ctatggttgc 7440 tttgacgagc acgtataacg tgctttcctc gttagaatca gagcgggagc taaacaggag 7500 gccgattaaa gggattttag acaggaacgg tacgccagaa tcctgagaag tgtttttata 7560 atcagtgagg ccaccgagta aaagagtctg tccatcacgc aaattaaccg ttgtcgcaat 7620 acttctttga ttagtaataa catcacttgc ctgagtagaa gaactcaaac tatcggcctt 7680 gctggtaata tccagaacaa tattaccgcc agccattgca acggaatcgc cattcgccat 7740 tcaggctgcg caactgttgg gaagggcgat cggtgcgggc ctcttcgcta ttacgcca 7798 <210> 11 <211> 7438 <212> ADN <213> Secuencia artificial <220> <223> pAAV-hAAT-omGALNS <400> 11 gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt 60 tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca actccatcac 120 taggggttcc ttgtagttaa tgattaaccc gccatgctac ttatctactc gacattgatt 180 attgactagg atctgatatc atcgatgaat tcgagctcgg tacccggccg cagatttagg 240 tgacactata gaatatgcat cactagtaag cttgcgaatt ccagtctaca gagaggtctc 300 tgacctctgc cccagctcca aggtcagcag gcagggaggg ctgtgtgttt gctgtttgct 360 gcttgcaatg tttgcccatt ttagggacat gagtaggctg aagtttgttc agtgtggact 420 tcagaggcag cacacaaaca gcaagcttgc gaattccagt ctacagagag gtctctgacc 480 tctgccccag ctccaaggtc agcaggcagg gagggctgtg tgtttgctgt ttgctgcttg 540 caatgtttgc ccattttagg gacatgagta ggctgaagtt tgttcagtgt ggacttcaga 600 ggcagcacac aaacagcaag cttgcgaatt ccagtctaca gagaggtctc tgacctctgc 660 cccagctcca aggtcagcag gcagggaggg ctgtgtgttt gctgtttgct gcttgcaatg 720 tttgcccatt ttagggacat gagtaggctg aagtttgttc agtgtggact tcagaggcag 780 cacacaaaca gcaagctttg ctctagactg gaattcgtcg acgagctccc tatagtgagt 840 cgtattagag gccgactgac ccggtacccg gggatcttgc taccagtgga acagccacta 900 aggattctgc agtgagagca gagggccagc taagtggtac tctcccagag actgtctgac 960 tcacgccacc ccctccacct tggacacagg acgctgtggt ttctgagcca ggtacaatga 1020 ctcctttcgg taagtgcagt ggaagctgta cactgcccag gcaaagcgtc cgggcagcgt 1080 aggcgggcga ctcagatccc agccagtgga cttagcccct gtttgctcct ccgataactg 1140 gggtgacctt ggttaatatt caccagcagc ctcccccgtt gcccctctgg atccactgct 1200 taaatacgga cgaggacagg gccctgtctc ctcagcttca ggcaccacca ctgacctggg 1260 acagtgaatg tccccctgat ctgcggccgt gactctctta aggtagcctt gcagaagttg 1320 gtcgtgaggc actgggcagg taagtatcaa ggttacaaga caggtttaag gagaccaata 1380 gaaactgggc ttgtcgagac agagaagact cttgcgtttc tgataggcac ctattggtct 1440 tactgacatc cactttgcct ttctctccac aggtgtccac tcccagttca attacagctc 1500 ttaaggctag agtacttaat acgactcact ataggctagc ctcgacctcg agacgcgtgc 1560 caccatggct gcttgtacag ccgctcagca gctgctgctg gtgctgtctg ctctgggact 1620 gctggctgct ggcgctcctc agcctcctaa catcgtgctg ctgctgatgg acgacatggg 1680 ctggggcgat ctgggagtga acggcgagcc tagcagagag acacccaacc tggacagaat 1740 ggccgccgag ggcatgctgt tccccagctt ctacagcgcc aaccccctgt gcagcccttc 1800 tagagccgct ctgctgaccg gcagactgcc catcagaaac ggcttctaca ccaccaacgc 1860 ccacgccaga aacgcctaca caccccagga aatcatgggc ggcatcccca acagcgagca 1920 tctgctgcct gagctgctga agaaggccgg ctacaccaac aagatcgtgg gcaagtggca 1980 cctgggccac agaccccagt tccaccctct gaagcacggc ttcgacgagt ggttcggcag 2040 ccccaactgt cacttcggcc cctacgacaa caaggccaag cccaacatcc ccgtgtacag 2100 agactgggag atggtgggaa gattctacga agagttcccc atcaacagaa agaccggcga 2160 ggccaacctg acccagctgt acacacagga agccctggac ttcatccaga cccagcacgc 2220 cagacagagc cccttcttcc tgtactgggc catcgacgcc acacacgccc ctgtgtacgc 2280 cagcagacag ttcctgggca ccagcctgag aggcagatat ggcgacgccg tgcgcgagat 2340 cgacgactct gtgggcaaga tcctgtccct gctgcagaac ctgggcatca gcaagaacac 2400 cttcgtgttc ttcaccagcg acaacggcgc tgccctgatc agcgctccta atgagggcgg 2460 cagcaacggc ccattcctgt gcggcaagca gaccacattc gagggcggaa tgagagagcc 2520 cgctatcgct tggtggcctg gccatatcgc tgctggccag gtgtcacacc agctgggcag 2580 catcatggac ctgttcacca cctccctgag cctggccgga ctgaagcctc ctagcgacag 2640 agtgatcgac ggcctggacc tgctgcccac catgctgaag ggccagatga tggacagacc 2700 catcttctac tacagaggca acaccctgat ggccgtgacc ctgggccagt acaaggccca 2760 cctgtggacc tggaccaaca gctgggaaga gtttacccag ggcaccgatt tctgccctgg 2820 ccagaatgtg tccggcgtga ccacccacac ccaggaagaa cacaccgagc tgcccctgat 2880 cttccacctg ggaagggacc ccggcgagag attccctctg agcttccaca gcgacgagta 2940 ccaggacgcc ctgagcagaa ccacccaggt ggtgcaggaa caccagaaaa gcctggtgcc 3000 cggccagccc cagctgaacg tgtgtaacca ggccgtgatg aactgggccc ctcccggatg 3060 tgaaaagctg ggaaagtgcc tgaccccccc tgagagcgtg cccgagaagt gtttctgggc 3120 ccactgagaa ttcgagctcg gtacccggga atcaattcac tcctcaggtg caggctgcct 3180 atcagaaggt ggtggctggt gtggccaatg ccctggctca caaataccac tgagatcttt 3240 ttccctctgc caaaaattat ggggacatca tgaagcccct tgagcatctg acttctggct 3300 aataaaggaa atttattttc attgcaatag tgtgttggaa ttttttgtgt ctctcactcg 3360 gaaggacata tgggagggca aatcatttaa aacatcagaa tgagtatttg gtttagagtt 3420 tggcaacata tgcccatatg ctggctgcca tgaacaaagg ttggctataa agaggtcatc 3480 agtatatgaa acagccccct gctgtccatt ccttattcca tagaaaagcc ttgacttgag 3540 gttagatttt ttttatattt tgttttgtgt tatttttttc tttaacatcc ctaaaatttt 3600 ccttacatgt tttactagcc agatttttcc tcctctcctg actactccca gtcatagctg 3660 tccctcttct cttatggaga tccctcgacc tgcagcccaa gctgtagata agtagcatgg 3720 cgggttaatc attaactaca aggaacccct agtgatggag ttggccactc cctctctgcg 3780 cgctcgctcg ctcactgagg ccgcccgggc tttgcccggg cggcctcagt gagcgagcga 3840 gcgcgcagct gcattaatga atcggccaac gcgcggggag aggcggtttg cgtattgggc 3900 gctcttccgc ttcctcgctc actgactcgc tgcgctcggt cgttcggctg cggcgagcgg 3960 tatcagctca ctcaaaggcg gtaatacggt tatccacaga atcaggggat aacgcaggaa 4020 agaacatgtg agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg 4080 cgtttttcca taggctccgc ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga 4140 ggtggcgaaa cccgacagga ctataaagat accaggcgtt tccccctgga agctccctcg 4200 tgcgctctcc tgttccgacc ctgccgctta ccggatacct gtccgccttt ctcccttcgg 4260 gaagcgtggc gctttctcat agctcacgct gtaggtatct cagttcggtg taggtcgttc 4320 gctccaagct gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc gccttatccg 4380 gtaactatcg tcttgagtcc aacccggtaa gacacgactt atcgccactg gcagcagcca 4440 ctggtaacag gattagcaga gcgaggtatg taggcggtgc tacagagttc ttgaagtggt 4500 ggcctaacta cggctacact agaagaacag tatttggtat ctgcgctctg ctgaagccag 4560 ttaccttcgg aaaaagagtt ggtagctctt gatccggcaa acaaaccacc gctggtagcg 4620 gtggtttttt tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct caagaagatc 4680 ctttgatctt ttctacgggg tctgacgctc agtggaacga aaactcacgt taagggattt 4740 tggtcatgag attatcaaaa aggatcttca cctagatcct tttaaattaa aaatgaagtt 4800 ttaaatcaat ctaaagtata tatgagtaaa cttggtctga cagttaccaa tgcttaatca 4860 gtgaggcacc tatctcagcg atctgtctat ttcgttcatc catagttgcc tgactccccg 4920 tcgtgtagat aactacgata cgggagggct taccatctgg ccccagtgct gcaatgatac 4980 cgcgagaccc acgctcaccg gctccagatt tatcagcaat aaaccagcca gccggaaggg 5040 ccgagcgcag aagtggtcct gcaactttat ccgcctccat ccagtctatt aattgttgcc 5100 gggaagctag agtaagtagt tcgccagtta atagtttgcg caacgttgtt gccattgcta 5160 caggcatcgt ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc ggttcccaac 5220 gatcaaggcg agttacatga tcccccatgt tgtgcaaaaa agcggttagc tccttcggtc 5280 ctccgatcgt tgtcagaagt aagttggccg cagtgttatc actcatggtt atggcagcac 5340 tgcataattc tcttactgtc atgccatccg taagatgctt ttctgtgact ggtgagtact 5400 caaccaagtc attctgagaa tagtgtatgc ggcgaccgag ttgctcttgc ccggcgtcaa 5460 tacgggataa taccgcgcca catagcagaa ctttaaaagt gctcatcatt ggaaaacgtt 5520 cttcggggcg aaaactctca aggatcttac cgctgttgag atccagttcg atgtaaccca 5580 ctcgtgcacc caactgatct tcagcatctt ttactttcac cagcgtttct gggtgagcaa 5640 aaacaggaag gcaaaatgcc gcaaaaaagg gaataagggc gacacggaaa tgttgaatac 5700 tcatactctt cctttttcaa tattattgaa gcatttatca gggttattgt ctcatgagcg 5760 gatacatatt tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc acatttcccc 5820 gaaaagtgcc acctgacgtc taagaaacca ttattatcat gacattaacc tataaaaata 5880 ggcgtatcac gaggcccttt cgtctcgcgc gtttcggtga tgacggtgaa aacctctgac 5940 acatgcagct cccggagacg gtcacagctt gtctgtaagc ggatgccggg agcagacaag 6000 cccgtcaggg cgcgtcagcg ggtgttggcg ggtgtcgggg ctggcttaac tatgcggcat 6060 cagagcagat tgtactgaga gtgcaccata tgcggtgtga aataccgcac agatgcgtaa 6120 ggagaaaata ccgcatcagg cgattccaac atccaataaa tcatacaggc aaggcaaaga 6180 attagcaaaa ttaagcaata aagcctcaga gcataaagct aaatcggttg taccaaaaac 6240 attatgaccc tgtaatactt ttgcgggaga agcctttatt tcaacgcaag gataaaaatt 6300 tttagaaccc tcatatattt taaatgcaat gcctgagtaa tgtgtaggta aagattcaaa 6360 cgggtgagaa aggccggaga cagtcaaatc accatcaata tgatattcaa ccgttctagc 6420 tgataaattc atgccggaga gggtagctat ttttgagagg tctctacaaa ggctatcagg 6480 tcattgcctg agagtctgga gcaaacaaga gaatcgatga acggtaatcg taaaactagc 6540 atgtcaatca tatgtacccc ggttgataat cagaaaagcc ccaaaaacag gaagattgta 6600 taagcaaata tttaaattgt aagcgttaat attttgttaa aattcgcgtt aaatttttgt 6660 taaatcagct cattttttaa ccaataggcc gaaatcggca aaatccctta taaatcaaaa 6720 gaatagaccg agatagggtt gagtgttgtt ccagtttgga acaagagtcc actattaaag 6780 aacgtggact ccaacgtcaa agggcgaaaa accgtctatc agggcgatgg cccactacgt 6840 gaaccatcac cctaatcaag ttttttgggg tcgaggtgcc gtaaagcact aaatcggaac 6900 cctaaaggga gcccccgatt tagagcttga cggggaaagc cggcgaacgt ggcgagaaag 6960 gaagggaaga aagcgaaagg agcgggcgct agggcgctgg caagtgtagc ggtcacgctg 7020 cgcgtaacca ccacacccgc cgcgcttaat gcgccgctac agggcgcgta ctatggttgc 7080 tttgacgagc acgtataacg tgctttcctc gttagaatca gagcgggagc taaacaggag 7140 gccgattaaa gggattttag acaggaacgg tacgccagaa tcctgagaag tgtttttata 7200 atcagtgagg ccaccgagta aaagagtctg tccatcacgc aaattaaccg ttgtcgcaat 7260 acttctttga ttagtaataa catcacttgc ctgagtagaa gaactcaaac tatcggcctt 7320 gctggtaata tccagaacaa tattaccgcc agccattgca acggaatcgc cattcgccat 7380 tcaggctgcg caactgttgg gaagggcgat cggtgcgggc ctcttcgcta ttacgcca 7438 <210> 12 <211> 4215 <212> ADN <213> Secuencia artificial <220> <223> AAV9-CAG-hGALNS <400> 12 gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt 60 tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca actccatcac 120 taggggttcc ttgtagttaa tgattaaccc gccatgctac ttatctactc gacattgatt 180 attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc catatatgga 240 gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca acgacccccg 300 cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga ctttccattg 360 acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc aagtgtatca 420 tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc 480 ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat tagtcatcgc 540 tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct cccccccctc 600 cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga tgggggcggg 660 gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg gcggggcgag 720 gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc cttttatggc 780 gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg gagtcgctgc 840 gttgccttcg ccccgtgccc cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac 900 tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg ggctgtaatt 960 agcgcttggt ttaatgacgg cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc 1020 tccgggaggg ccctttgtgc ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg 1080 tggggagcgc cgcgtgcggc tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg 1140 cggggctttg tgcgctccgc agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc 1200 ggtgcggggg gggctgcgag gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt 1260 gagcaggggg tgtgggcgcg tcggtcgggc tgcaaccccc cctgcacccc cctccccgag 1320 ttgctgagca cggcccggct tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg 1380 ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg 1440 ccggggaggg ctcgggggag gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg 1500 cggcgagccg cagccattgc cttttatggt aatcgtgcga gagggcgcag ggacttcctt 1560 tgtcccaaat ctgtgcggag ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc 1620 gcggggcgaa gcggtgcggc gccggcagga aggaaatggg cggggagggc cttcgtgcgt 1680 cgccgcgccg ccgtcccctt ctccctctcc agcctcgggg ctgtccgcgg ggggacggct 1740 gccttcgggg gggacggggc agggcggggt tcggcttctg gcgtgtgacc ggcggctcta 1800 gagcctctgc taaccatgtt catgccttct tctttttcct acagctcctg ggcaacgtgc 1860 tggttattgt gctgtctcat cattttggca aagaattgat taattcgagc gaacgcgtgc 1920 caccatggcg gcggttgtcg cggcgacgag gtggtggcag ctgttgctgg tgctcagcgc 1980 cgcggggatg ggggcctcgg gcgccccgca gccccccaac atcctgctcc tgctcatgga 2040 cgacatggga tggggtgacc tcggggtgta tggagagccc tccagagaga ccccgaattt 2100 ggaccggatg gctgcagaag ggctgctttt cccaaacttc tattctgcca accctctgtg 2160 ctcgccatcg agggcggcac tgctcacagg acggctaccc atccgcaatg gcttctacac 2220 caccaacgcc catgccagaa acgcctacac accgcaggag attgtgggcg gcatcccaga 2280 ctcggagcag ctcctgccgg agcttctgaa gaaggccggc tacgtcagca agattgtcgg 2340 caagtggcat ctgggtcaca ggccccagtt ccaccccctg aagcacggat ttgatgagtg 2400 gtttggatcc cccaactgcc actttggacc ttatgacaac aaggccaggc ccaacatccc 2460 tgtgtacagg gactgggaga tggttggcag atattatgaa gaatttccta ttaatctgaa 2520 gacgggggaa gccaacctca cccagatcta cctgcaggaa gccctggact tcattaagag 2580 acaggcacgg caccacccct ttttcctcta ctgggctgtc gacgccacgc acgcacccgt 2640 ctatgcctcc aaacccttct tgggcaccag tcagcgaggg cggtatggag acgccgtccg 2700 ggagattgat gacagcattg ggaagatact ggagctcctc caagacctgc acgtcgcgga 2760 caacaccttc gtcttcttca cgtcggacaa cggcgctgcc ctcatttccg cccccgaaca 2820 aggtggcagc aacggcccct ttctgtgtgg gaagcagacc acgtttgaag gagggatgag 2880 ggagcctgcc ctcgcatggt ggccagggca cgtcactgca ggccaggtga gccaccagct 2940 gggcagcatc atggacctct tcaccaccag cctggccctt gcgggcctga cgccgcccag 3000 cgacagggcc attgatggcc tcaacctcct ccccaccctc ctgcagggcc ggctgatgga 3060 caggcctatc ttctattacc gtggcgacac gctgatggcg gccaccctcg ggcagcacaa 3120 ggctcacttc tggacctgga ccaactcctg ggagaacttc agacagggca ttgatttctg 3180 ccctgggcag aacgtttcag gggtcacaac tcacaatctg gaagaccaca cgaagctgcc 3240 cctgatcttc cacctgggac gggacccagg ggagaggttc cccctcagct ttgccagcgc 3300 cgagtaccag gaggccctca gcaggatcac ctcggtcgtc cagcagcacc aggaggcctt 3360 ggtccccgcg cagccccagc tcaacgtgtg caactgggcg gtcatgaact gggcacctcc 3420 gggctgtgaa aagttaggga agtgtctgac acctccagaa tccattccca agaagtgcct 3480 ctggtcccac taggaattcg agctcggtac ccgggaatca attcactcct caggtgcagg 3540 ctgcctatca gaaggtggtg gctggtgtgg ccaatgccct ggctcacaaa taccactgag 3600 atctttttcc ctctgccaaa aattatgggg acatcatgaa gccccttgag catctgactt 3660 ctggctaata aaggaaattt attttcattg caatagtgtg ttggaatttt ttgtgtctct 3720 cactcggaag gacatatggg agggcaaatc atttaaaaca tcagaatgag tatttggttt 3780 agagtttggc aacatatgcc catatgctgg ctgccatgaa caaaggttgg ctataaagag 3840 gtcatcagta tatgaaacag ccccctgctg tccattcctt attccataga aaagccttga 3900 cttgaggtta gatttttttt atattttgtt ttgtgttatt tttttcttta acatccctaa 3960 aattttcctt acatgtttta ctagccagat ttttcctcct ctcctgacta ctcccagtca 4020 tagctgtccc tcttctctta tggagatccc tcgacctgca gcccaagctg tagataagta 4080 gcatggcggg ttaatcatta actacaagga acccctagtg atggagttgg ccactccctc 4140 tctgcgcgct cgctcgctca ctgaggccgc ccgggctttg cccgggcggc ctcagtgagc 4200 gagcgagcgc gcagc 4215 <210> 13 <211> 4215 <212> ADN <213> Secuencia artificial <220> <223> AAV9-CAG-ohGALNS-versión1 <400> 13 gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt 60 tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca actccatcac 120 taggggttcc ttgtagttaa tgattaaccc gccatgctac ttatctactc gacattgatt 180 attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc catatatgga 240 gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca acgacccccg 300 cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga ctttccattg 360 acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc aagtgtatca 420 tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc 480 ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat tagtcatcgc 540 tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct cccccccctc 600 cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga tgggggcggg 660 gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg gcggggcgag 720 gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc cttttatggc 780 gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg gagtcgctgc 840 gttgccttcg ccccgtgccc cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac 900 tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg ggctgtaatt 960 agcgcttggt ttaatgacgg cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc 1020 tccgggaggg ccctttgtgc ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg 1080 tggggagcgc cgcgtgcggc tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg 1140 cggggctttg tgcgctccgc agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc 1200 ggtgcggggg gggctgcgag gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt 1260 gagcaggggg tgtgggcgcg tcggtcgggc tgcaaccccc cctgcacccc cctccccgag 1320 ttgctgagca cggcccggct tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg 1380 ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg 1440 ccggggaggg ctcgggggag gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg 1500 cggcgagccg cagccattgc cttttatggt aatcgtgcga gagggcgcag ggacttcctt 1560 tgtcccaaat ctgtgcggag ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc 1620 gcggggcgaa gcggtgcggc gccggcagga aggaaatggg cggggagggc cttcgtgcgt 1680 cgccgcgccg ccgtcccctt ctccctctcc agcctcgggg ctgtccgcgg ggggacggct 1740 gccttcgggg gggacggggc agggcggggt tcggcttctg gcgtgtgacc ggcggctcta 1800 gagcctctgc taaccatgtt catgccttct tctttttcct acagctcctg ggcaacgtgc 1860 tggttattgt gctgtctcat cattttggca aagaattgat taattcgagc gaacgcgtgc 1920 caccatggct gctgtggtgg ctgccacaag atggtggcag ctgctgctgg tgctgagcgc 1980 cgctggaatg ggagcttctg gcgctcccca gccccccaat attctcctgc tgctgatgga 2040 cgacatgggc tggggcgatc tgggagtgta cggcgagcct agcagagaga cacccaacct 2100 ggacagaatg gccgccgagg gcctgctgtt ccccaacttc tacagcgcca accccctgtg 2160 cagcccatct agagccgctc tgctgaccgg cagactgccc atcagaaacg gcttctacac 2220 caccaacgcc cacgcccgga acgcctacac accccaggaa atcgtgggcg gcatccccga 2280 tagcgaacag ctgctgcctg agctgctgaa gaaagccggc tacgtgtcca agatcgtggg 2340 caagtggcac ctgggccaca gaccccagtt ccaccctctg aagcacggct tcgacgagtg 2400 gttcggcagc cccaattgcc acttcggccc ctacgacaac aaggccagac ccaacatccc 2460 cgtgtaccgg gactgggaga tggtgggacg gtactacgaa gagttcccca tcaacctgaa 2520 aaccggcgag gccaacctga cccagatcta cctgcaggaa gccctggact tcatcaagcg 2580 gcaggcccgg caccaccctt tctttctgta ctgggccgtg gacgccaccc acgcccctgt 2640 gtatgccagc aagcctttcc tgggcaccag ccagagaggc agatacggcg acgccgtgcg 2700 cgagatcgat gacagcatcg gcaagatcct ggaactgctg caggacctgc acgtggccga 2760 caacaccttc gtgttcttca ccagcgacaa cggcgctgcc ctgatctctg ctcctgagca 2820 gggcggcagc aacggcccat ttctgtgtgg caagcagacc accttcgagg gcggcatgag 2880 agaacctgcc ctggcttggt ggcctggcca tgtgacagct ggacaggtgt cccaccagct 2940 gggcagcatc atggacctgt tcaccaccag cctggccctg gccggactga cacctccaag 3000 cgacagagcc atcgacggcc tgaacctgct gcctaccctg ctgcagggac ggctgatgga 3060 ccggcccatc ttctactaca gaggcgacac cctgatggcc gccacactgg gacagcacaa 3120 ggcccacttt tggacctgga ccaacagctg ggagaacttc cggcagggca tcgacttttg 3180 ccctggccag aatgtgtccg gcgtgaccac ccacaacctg gaagatcaca ccaagctgcc 3240 cctgattttc cacctgggca gagatcccgg cgagcggttc cctctgtctt ttgccagcgc 3300 cgagtaccag gaagctctga gcagaatcac ctccgtggtg cagcagcacc aggaagcact 3360 ggtgcctgct cagccccagc tgaacgtgtg caattgggcc gtgatgaact gggcccctcc 3420 cggctgtgaa aagctgggaa agtgcctgac cccccctgag agcatcccca agaaatgcct 3480 gtggtcccac tgagaattcg agctcggtac ccgggaatca attcactcct caggtgcagg 3540 ctgcctatca gaaggtggtg gctggtgtgg ccaatgccct ggctcacaaa taccactgag 3600 atctttttcc ctctgccaaa aattatgggg acatcatgaa gccccttgag catctgactt 3660 ctggctaata aaggaaattt attttcattg caatagtgtg ttggaatttt ttgtgtctct 3720 cactcggaag gacatatggg agggcaaatc atttaaaaca tcagaatgag tatttggttt 3780 agagtttggc aacatatgcc catatgctgg ctgccatgaa caaaggttgg ctataaagag 3840 gtcatcagta tatgaaacag ccccctgctg tccattcctt attccataga aaagccttga 3900 cttgaggtta gatttttttt atattttgtt ttgtgttatt tttttcttta acatccctaa 3960 aattttcctt acatgtttta ctagccagat ttttcctcct ctcctgacta ctcccagtca 4020 tagctgtccc tcttctctta tggagatccc tcgacctgca gcccaagctg tagataagta 4080 gcatggcggg ttaatcatta actacaagga acccctagtg atggagttgg ccactccctc 4140 tctgcgcgct cgctcgctca ctgaggccgc ccgggctttg cccgggcggc ctcagtgagc 4200 gagcgagcgc gcagc 4215 <210> 14 <211> 4215 <212> ADN <213> Secuencia artificial <220> <223> AAV9-CAG-ohGALNS-versión2 <400> 14 gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt 60 tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca actccatcac 120 taggggttcc ttgtagttaa tgattaaccc gccatgctac ttatctactc gacattgatt 180 attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc catatatgga 240 gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca acgacccccg 300 cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga ctttccattg 360 acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc aagtgtatca 420 tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc 480 ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat tagtcatcgc 540 tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct cccccccctc 600 cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga tgggggcggg 660 gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg gcggggcgag 720 gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc cttttatggc 780 gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg gagtcgctgc 840 gttgccttcg ccccgtgccc cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac 900 tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg ggctgtaatt 960 agcgcttggt ttaatgacgg cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc 1020 tccgggaggg ccctttgtgc ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg 1080 tggggagcgc cgcgtgcggc tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg 1140 cggggctttg tgcgctccgc agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc 1200 ggtgcggggg gggctgcgag gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt 1260 gagcaggggg tgtgggcgcg tcggtcgggc tgcaaccccc cctgcacccc cctccccgag 1320 ttgctgagca cggcccggct tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg 1380 ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg 1440 ccggggaggg ctcgggggag gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg 1500 cggcgagccg cagccattgc cttttatggt aatcgtgcga gagggcgcag ggacttcctt 1560 tgtcccaaat ctgtgcggag ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc 1620 gcggggcgaa gcggtgcggc gccggcagga aggaaatggg cggggagggc cttcgtgcgt 1680 cgccgcgccg ccgtcccctt ctccctctcc agcctcgggg ctgtccgcgg ggggacggct 1740 gccttcgggg gggacggggc agggcggggt tcggcttctg gcgtgtgacc ggcggctcta 1800 gagcctctgc taaccatgtt catgccttct tctttttcct acagctcctg ggcaacgtgc 1860 tggttattgt gctgtctcat cattttggca aagaattgat taattcgagc gaacgcgtgc 1920 caccatggcc gccgtggtcg ccgcaactcg atggtggcag ctgctgctgg tcctgtccgc 1980 cgctggcatg ggagcctctg gagcccctca gccccctaac atcctgctgc tgctgatgga 2040 cgatatggga tggggcgacc tgggcgtgta cggagagcca agccgggaga cacccaatct 2100 ggataggatg gcagcagagg gcctgctgtt cccaaacttt tattccgcca atcctctgtg 2160 cagcccatcc cgcgccgccc tgctgaccgg ccggctgccc atcagaaacg gcttctacac 2220 cacaaacgcc cacgcccgga atgcctatac acctcaggag atcgtgggcg gcatccccga 2280 ctctgagcag ctgctgcctg agctgctgaa gaaggccggc tacgtgagca agatcgtggg 2340 caagtggcac ctgggacaca ggccacagtt ccaccctctg aagcacggct tcgatgagtg 2400 gtttggcagc cccaattgtc actttggccc ttacgacaac aaggccagac ccaatatccc 2460 cgtgtacaga gattgggaga tggtgggcag gtactatgag gagttcccta tcaacctgaa 2520 gaccggcgag gccaatctga cacagatcta cctgcaggag gccctggact ttatcaagag 2580 gcaggcccgc caccacccct tctttctgta ctgggcagtg gatgcaaccc acgcaccagt 2640 gtatgcctct aagcccttcc tgggcacaag ccagaggggc agatatggcg acgccgtgag 2700 agagatcgac gattctatcg gcaagatcct ggagctgctg caggacctgc acgtggccga 2760 taacaccttc gtgttcttca catccgataa tggagccgcc ctgatctccg ccccagagca 2820 gggaggatct aacggaccct tcctgtgcgg caagcagacc acatttgagg gaggaatgag 2880 ggagcctgcc ctggcatggt ggccaggcca cgtgaccgcc ggccaggtga gccaccagct 2940 gggctccatc atggacctgt tcaccacaag cctggccctg gcaggcctga ccccaccatc 3000 cgacagagcc atcgatggcc tgaatctgct gcctacactg ctgcagggca ggctgatgga 3060 ccgcccaatc ttctactata ggggcgatac cctgatggca gccacactgg gacagcacaa 3120 ggcacacttt tggacctgga caaactcctg ggagaatttc cgccagggca tcgatttttg 3180 tccaggccag aacgtgtctg gcgtgaccac acacaatctg gaggaccaca ccaagctgcc 3240 cctgatcttt cacctgggcc gggatcctgg cgagagattc ccactgtctt ttgccagcgc 3300 cgagtaccag gaggccctgt cccggatcac atctgtggtg cagcagcacc aggaggccct 3360 ggtgccagca cagccccagc tgaacgtgtg caattgggcc gtgatgaact gggcccctcc 3420 aggctgtgag aaactgggca aatgtctgac tccccctgaa tctatcccta agaagtgtct 3480 gtggtcccat taggaattcg agctcggtac ccgggaatca attcactcct caggtgcagg 3540 ctgcctatca gaaggtggtg gctggtgtgg ccaatgccct ggctcacaaa taccactgag 3600 atctttttcc ctctgccaaa aattatgggg acatcatgaa gccccttgag catctgactt 3660 ctggctaata aaggaaattt attttcattg caatagtgtg ttggaatttt ttgtgtctct 3720 cactcggaag gacatatggg agggcaaatc atttaaaaca tcagaatgag tatttggttt 3780 agagtttggc aacatatgcc catatgctgg ctgccatgaa caaaggttgg ctataaagag 3840 gtcatcagta tatgaaacag ccccctgctg tccattcctt attccataga aaagccttga 3900 cttgaggtta gatttttttt atattttgtt ttgtgttatt tttttcttta acatccctaa 3960 aattttcctt acatgtttta ctagccagat ttttcctcct ctcctgacta ctcccagtca 4020 tagctgtccc tcttctctta tggagatccc tcgacctgca gcccaagctg tagataagta 4080 gcatggcggg ttaatcatta actacaagga acccctagtg atggagttgg ccactccctc 4140 tctgcgcgct cgctcgctca ctgaggccgc ccgggctttg cccgggcggc ctcagtgagc 4200 gagcgagcgc gcagc 4215 <210> 15 <211> 4215 <212> ADN <213> Secuencia artificial <220> <223> AAV9-CAG-ohGALNS-versión3 <400> 15 gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt 60 tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca actccatcac 120 taggggttcc ttgtagttaa tgattaaccc gccatgctac ttatctactc gacattgatt 180 attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc catatatgga 240 gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca acgacccccg 300 cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga ctttccattg 360 acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc aagtgtatca 420 tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc 480 ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat tagtcatcgc 540 tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct cccccccctc 600 cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga tgggggcggg 660 gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg gcggggcgag 720 gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc cttttatggc 780 gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg gagtcgctgc 840 gttgccttcg ccccgtgccc cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac 900 tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg ggctgtaatt 960 agcgcttggt ttaatgacgg cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc 1020 tccgggaggg ccctttgtgc ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg 1080 tggggagcgc cgcgtgcggc tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg 1140 cggggctttg tgcgctccgc agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc 1200 ggtgcggggg gggctgcgag gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt 1260 gagcaggggg tgtgggcgcg tcggtcgggc tgcaaccccc cctgcacccc cctccccgag 1320 ttgctgagca cggcccggct tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg 1380 ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg 1440 ccggggaggg ctcgggggag gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg 1500 cggcgagccg cagccattgc cttttatggt aatcgtgcga gagggcgcag ggacttcctt 1560 tgtcccaaat ctgtgcggag ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc 1620 gcggggcgaa gcggtgcggc gccggcagga aggaaatggg cggggagggc cttcgtgcgt 1680 cgccgcgccg ccgtcccctt ctccctctcc agcctcgggg ctgtccgcgg ggggacggct 1740 gccttcgggg gggacggggc agggcggggt tcggcttctg gcgtgtgacc ggcggctcta 1800 gagcctctgc taaccatgtt catgccttct tctttttcct acagctcctg ggcaacgtgc 1860 tggttattgt gctgtctcat cattttggca aagaattgat taattcgagc gaacgcgtgc 1920 caccatggca gcggtggtgg ccgcgaccag atggtggcag cttctcctgg tcctgtcggc 1980 cgcgggaatg ggtgcctcgg gcgcgccgca gccccctaac attctgctgc tgctgatgga 2040 cgatatggga tggggcgacc tgggggtgta cggagagcct tcacgggaaa cccccaacct 2100 ggaccgcatg gcggctgaag gcctgctgtt cccgaacttt tactccgcga atccgctgtg 2160 ctccccttcg cgcgccgccc tcctgaccgg acggttgcct atccgcaacg gcttctacac 2220 tactaacgca cacgccagga acgcctacac cccgcaagaa attgtgggag gaatcccgga 2280 ttccgaacag ctgctgccgg aactgctgaa gaaggccggc tacgtgtcga agatcgtggg 2340 aaagtggcat cttggtcatc ggcctcagtt ccacccgctc aagcacgggt tcgatgaatg 2400 gttcggatcc cccaactgcc actttggccc ctacgacaac aaggctcggc ctaacattcc 2460 cgtctaccgg gactgggaaa tggtcggaag atactacgag gagttcccca tcaacctcaa 2520 gactggcgaa gccaacctga ctcagatcta cctccaagag gccctggact tcatcaagcg 2580 ccaggcccgg caccacccgt tcttcctcta ttgggcggtg gacgccaccc atgcccccgt 2640 gtacgcatca aagccgttcc ttggaactag ccagagaggc agatacgggg atgccgtgcg 2700 cgaaattgat gactccatcg gaaagatcct ggagctgctc caggacctcc atgtcgccga 2760 caataccttc gtgttcttta cttccgataa cggcgccgcc ttgatcagcg ccccggagca 2820 gggaggctcc aacggccctt ttctctgtgg gaaacagacc accttcgagg gagggatgcg 2880 ggaaccggct ctggcttggt ggcccggaca cgtgaccgcc ggccaagtgt cgcaccagct 2940 tggctccatc atggacttgt tcaccacctc actggccctc gcggggctca ccccaccaag 3000 cgaccgagcg attgacggtc tgaacttgct ccccactctg ctgcaaggaa ggctgatgga 3060 ccggcccatc ttctactatc ggggcgatac cttgatggcc gccaccctgg gacagcacaa 3120 ggcccacttt tggacttgga caaactcctg ggagaacttc cgccaaggga tcgacttctg 3180 ccccggtcaa aacgtgtccg gcgtgaccac ccacaacctg gaggaccata ccaagctgcc 3240 actgattttc caccttggtc gggacccagg agagagattc ccactgagct tcgcctccgc 3300 cgaatatcag gaagcactgt cccggatcac gagcgtggtg cagcagcatc aggaggccct 3360 ggtgccggcg cagccgcagc tcaatgtctg caactgggct gtgatgaact gggcaccccc 3420 tggctgcgaa aaactcggga agtgtctgac tccacctgag agcatcccga agaagtgcct 3480 gtggagccac taggaattcg agctcggtac ccgggaatca attcactcct caggtgcagg 3540 ctgcctatca gaaggtggtg gctggtgtgg ccaatgccct ggctcacaaa taccactgag 3600 atctttttcc ctctgccaaa aattatgggg acatcatgaa gccccttgag catctgactt 3660 ctggctaata aaggaaattt attttcattg caatagtgtg ttggaatttt ttgtgtctct 3720 cactcggaag gacatatggg agggcaaatc atttaaaaca tcagaatgag tatttggttt 3780 agagtttggc aacatatgcc catatgctgg ctgccatgaa caaaggttgg ctataaagag 3840 gtcatcagta tatgaaacag ccccctgctg tccattcctt attccataga aaagccttga 3900 cttgaggtta gatttttttt atattttgtt ttgtgttatt tttttcttta acatccctaa 3960 aattttcctt acatgtttta ctagccagat ttttcctcct ctcctgacta ctcccagtca 4020 tagctgtccc tcttctctta tggagatccc tcgacctgca gcccaagctg tagataagta 4080 gcatggcggg ttaatcatta actacaagga acccctagtg atggagttgg ccactccctc 4140 tctgcgcgct cgctcgctca ctgaggccgc ccgggctttg cccgggcggc ctcagtgagc 4200 gagcgagcgc gcagc 4215 <210> 16 <211> 4209 <212> ADN <213> Secuencia artificial <220> <223> AAV9-CAG-omGALNS/ AAV8-CAG-omGALNS <400> 16 gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt 60 tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca actccatcac 120 taggggttcc ttgtagttaa tgattaaccc gccatgctac ttatctactc gacattgatt 180 attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc catatatgga 240 gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca acgacccccg 300 cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga ctttccattg 360 acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc aagtgtatca 420 tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc 480 ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat tagtcatcgc 540 tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct cccccccctc 600 cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga tgggggcggg 660 gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg gcggggcgag 720 gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc cttttatggc 780 gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg gagtcgctgc 840 gttgccttcg ccccgtgccc cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac 900 tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg ggctgtaatt 960 agcgcttggt ttaatgacgg cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc 1020 tccgggaggg ccctttgtgc ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg 1080 tggggagcgc cgcgtgcggc tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg 1140 cggggctttg tgcgctccgc agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc 1200 ggtgcggggg gggctgcgag gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt 1260 gagcaggggg tgtgggcgcg tcggtcgggc tgcaaccccc cctgcacccc cctccccgag 1320 ttgctgagca cggcccggct tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg 1380 ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg 1440 ccggggaggg ctcgggggag gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg 1500 cggcgagccg cagccattgc cttttatggt aatcgtgcga gagggcgcag ggacttcctt 1560 tgtcccaaat ctgtgcggag ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc 1620 gcggggcgaa gcggtgcggc gccggcagga aggaaatggg cggggagggc cttcgtgcgt 1680 cgccgcgccg ccgtcccctt ctccctctcc agcctcgggg ctgtccgcgg ggggacggct 1740 gccttcgggg gggacggggc agggcggggt tcggcttctg gcgtgtgacc ggcggctcta 1800 gagcctctgc taaccatgtt catgccttct tctttttcct acagctcctg ggcaacgtgc 1860 tggttattgt gctgtctcat cattttggca aagaattgat taattcgagc gaacgcgtgc 1920 caccatggct gcttgtacag ccgctcagca gctgctgctg gtgctgtctg ctctgggact 1980 gctggctgct ggcgctcctc agcctcctaa catcgtgctg ctgctgatgg acgacatggg 2040 ctggggcgat ctgggagtga acggcgagcc tagcagagag acacccaacc tggacagaat 2100 ggccgccgag ggcatgctgt tccccagctt ctacagcgcc aaccccctgt gcagcccttc 2160 tagagccgct ctgctgaccg gcagactgcc catcagaaac ggcttctaca ccaccaacgc 2220 ccacgccaga aacgcctaca caccccagga aatcatgggc ggcatcccca acagcgagca 2280 tctgctgcct gagctgctga agaaggccgg ctacaccaac aagatcgtgg gcaagtggca 2340 cctgggccac agaccccagt tccaccctct gaagcacggc ttcgacgagt ggttcggcag 2400 ccccaactgt cacttcggcc cctacgacaa caaggccaag cccaacatcc ccgtgtacag 2460 agactgggag atggtgggaa gattctacga agagttcccc atcaacagaa agaccggcga 2520 ggccaacctg acccagctgt acacacagga agccctggac ttcatccaga cccagcacgc 2580 cagacagagc cccttcttcc tgtactgggc catcgacgcc acacacgccc ctgtgtacgc 2640 cagcagacag ttcctgggca ccagcctgag aggcagatat ggcgacgccg tgcgcgagat 2700 cgacgactct gtgggcaaga tcctgtccct gctgcagaac ctgggcatca gcaagaacac 2760 cttcgtgttc ttcaccagcg acaacggcgc tgccctgatc agcgctccta atgagggcgg 2820 cagcaacggc ccattcctgt gcggcaagca gaccacattc gagggcggaa tgagagagcc 2880 cgctatcgct tggtggcctg gccatatcgc tgctggccag gtgtcacacc agctgggcag 2940 catcatggac ctgttcacca cctccctgag cctggccgga ctgaagcctc ctagcgacag 3000 agtgatcgac ggcctggacc tgctgcccac catgctgaag ggccagatga tggacagacc 3060 catcttctac tacagaggca acaccctgat ggccgtgacc ctgggccagt acaaggccca 3120 cctgtggacc tggaccaaca gctgggaaga gtttacccag ggcaccgatt tctgccctgg 3180 ccagaatgtg tccggcgtga ccacccacac ccaggaagaa cacaccgagc tgcccctgat 3240 cttccacctg ggaagggacc ccggcgagag attccctctg agcttccaca gcgacgagta 3300 ccaggacgcc ctgagcagaa ccacccaggt ggtgcaggaa caccagaaaa gcctggtgcc 3360 cggccagccc cagctgaacg tgtgtaacca ggccgtgatg aactgggccc ctcccggatg 3420 tgaaaagctg ggaaagtgcc tgaccccccc tgagagcgtg cccgagaagt gtttctgggc 3480 ccactgagaa ttcgagctcg gtacccggga atcaattcac tcctcaggtg caggctgcct 3540 atcagaaggt ggtggctggt gtggccaatg ccctggctca caaataccac tgagatcttt 3600 ttccctctgc caaaaattat ggggacatca tgaagcccct tgagcatctg acttctggct 3660 aataaaggaa atttattttc attgcaatag tgtgttggaa ttttttgtgt ctctcactcg 3720 gaaggacata tgggagggca aatcatttaa aacatcagaa tgagtatttg gtttagagtt 3780 tggcaacata tgcccatatg ctggctgcca tgaacaaagg ttggctataa agaggtcatc 3840 agtatatgaa acagccccct gctgtccatt ccttattcca tagaaaagcc ttgacttgag 3900 gttagatttt ttttatattt tgttttgtgt tatttttttc tttaacatcc ctaaaatttt 3960 ccttacatgt tttactagcc agatttttcc tcctctcctg actactccca gtcatagctg 4020 tccctcttct cttatggaga tccctcgacc tgcagcccaa gctgtagata agtagcatgg 4080 cgggttaatc attaactaca aggaacccct agtgatggag ttggccactc cctctctgcg 4140 cgctcgctcg ctcactgagg ccgcccgggc tttgcccggg cggcctcagt gagcgagcga 4200 gcgcgcagc 4209 <210> 17 <211> 3849 <212> ADN <213> Secuencia artificial <220> <223> AAV8-hAAT-omGALNS <400> 17 gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt 60 tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca actccatcac 120 taggggttcc ttgtagttaa tgattaaccc gccatgctac ttatctactc gacattgatt 180 attgactagg atctgatatc atcgatgaat tcgagctcgg tacccggccg cagatttagg 240 tgacactata gaatatgcat cactagtaag cttgcgaatt ccagtctaca gagaggtctc 300 tgacctctgc cccagctcca aggtcagcag gcagggaggg ctgtgtgttt gctgtttgct 360 gcttgcaatg tttgcccatt ttagggacat gagtaggctg aagtttgttc agtgtggact 420 tcagaggcag cacacaaaca gcaagcttgc gaattccagt ctacagagag gtctctgacc 480 tctgccccag ctccaaggtc agcaggcagg gagggctgtg tgtttgctgt ttgctgcttg 540 caatgtttgc ccattttagg gacatgagta ggctgaagtt tgttcagtgt ggacttcaga 600 ggcagcacac aaacagcaag cttgcgaatt ccagtctaca gagaggtctc tgacctctgc 660 cccagctcca aggtcagcag gcagggaggg ctgtgtgttt gctgtttgct gcttgcaatg 720 tttgcccatt ttagggacat gagtaggctg aagtttgttc agtgtggact tcagaggcag 780 cacacaaaca gcaagctttg ctctagactg gaattcgtcg acgagctccc tatagtgagt 840 cgtattagag gccgactgac ccggtacccg gggatcttgc taccagtgga acagccacta 900 aggattctgc agtgagagca gagggccagc taagtggtac tctcccagag actgtctgac 960 tcacgccacc ccctccacct tggacacagg acgctgtggt ttctgagcca ggtacaatga 1020 ctcctttcgg taagtgcagt ggaagctgta cactgcccag gcaaagcgtc cgggcagcgt 1080 aggcgggcga ctcagatccc agccagtgga cttagcccct gtttgctcct ccgataactg 1140 gggtgacctt ggttaatatt caccagcagc ctcccccgtt gcccctctgg atccactgct 1200 taaatacgga cgaggacagg gccctgtctc ctcagcttca ggcaccacca ctgacctggg 1260 acagtgaatg tccccctgat ctgcggccgt gactctctta aggtagcctt gcagaagttg 1320 gtcgtgaggc actgggcagg taagtatcaa ggttacaaga caggtttaag gagaccaata 1380 gaaactgggc ttgtcgagac agagaagact cttgcgtttc tgataggcac ctattggtct 1440 tactgacatc cactttgcct ttctctccac aggtgtccac tcccagttca attacagctc 1500 ttaaggctag agtacttaat acgactcact ataggctagc ctcgacctcg agacgcgtgc 1560 caccatggct gcttgtacag ccgctcagca gctgctgctg gtgctgtctg ctctgggact 1620 gctggctgct ggcgctcctc agcctcctaa catcgtgctg ctgctgatgg acgacatggg 1680 ctggggcgat ctgggagtga acggcgagcc tagcagagag acacccaacc tggacagaat 1740 ggccgccgag ggcatgctgt tccccagctt ctacagcgcc aaccccctgt gcagcccttc 1800 tagagccgct ctgctgaccg gcagactgcc catcagaaac ggcttctaca ccaccaacgc 1860 ccacgccaga aacgcctaca caccccagga aatcatgggc ggcatcccca acagcgagca 1920 tctgctgcct gagctgctga agaaggccgg ctacaccaac aagatcgtgg gcaagtggca 1980 cctgggccac agaccccagt tccaccctct gaagcacggc ttcgacgagt ggttcggcag 2040 ccccaactgt cacttcggcc cctacgacaa caaggccaag cccaacatcc ccgtgtacag 2100 agactgggag atggtgggaa gattctacga agagttcccc atcaacagaa agaccggcga 2160 ggccaacctg acccagctgt acacacagga agccctggac ttcatccaga cccagcacgc 2220 cagacagagc cccttcttcc tgtactgggc catcgacgcc acacacgccc ctgtgtacgc 2280 cagcagacag ttcctgggca ccagcctgag aggcagatat ggcgacgccg tgcgcgagat 2340 cgacgactct gtgggcaaga tcctgtccct gctgcagaac ctgggcatca gcaagaacac 2400 cttcgtgttc ttcaccagcg acaacggcgc tgccctgatc agcgctccta atgagggcgg 2460 cagcaacggc ccattcctgt gcggcaagca gaccacattc gagggcggaa tgagagagcc 2520 cgctatcgct tggtggcctg gccatatcgc tgctggccag gtgtcacacc agctgggcag 2580 catcatggac ctgttcacca cctccctgag cctggccgga ctgaagcctc ctagcgacag 2640 agtgatcgac ggcctggacc tgctgcccac catgctgaag ggccagatga tggacagacc 2700 catcttctac tacagaggca acaccctgat ggccgtgacc ctgggccagt acaaggccca 2760 cctgtggacc tggaccaaca gctgggaaga gtttacccag ggcaccgatt tctgccctgg 2820 ccagaatgtg tccggcgtga ccacccacac ccaggaagaa cacaccgagc tgcccctgat 2880 cttccacctg ggaagggacc ccggcgagag attccctctg agcttccaca gcgacgagta 2940 ccaggacgcc ctgagcagaa ccacccaggt ggtgcaggaa caccagaaaa gcctggtgcc 3000 cggccagccc cagctgaacg tgtgtaacca ggccgtgatg aactgggccc ctcccggatg 3060 tgaaaagctg ggaaagtgcc tgaccccccc tgagagcgtg cccgagaagt gtttctgggc 3120 ccactgagaa ttcgagctcg gtacccggga atcaattcac tcctcaggtg caggctgcct 3180 atcagaaggt ggtggctggt gtggccaatg ccctggctca caaataccac tgagatcttt 3240 ttccctctgc caaaaattat ggggacatca tgaagcccct tgagcatctg acttctggct 3300 aataaaggaa atttattttc attgcaatag tgtgttggaa ttttttgtgt ctctcactcg 3360 gaaggacata tgggagggca aatcatttaa aacatcagaa tgagtatttg gtttagagtt 3420 tggcaacata tgcccatatg ctggctgcca tgaacaaagg ttggctataa agaggtcatc 3480 agtatatgaa acagccccct gctgtccatt ccttattcca tagaaaagcc ttgacttgag 3540 gttagatttt ttttatattt tgttttgtgt tatttttttc tttaacatcc ctaaaatttt 3600 ccttacatgt tttactagcc agatttttcc tcctctcctg actactccca gtcatagctg 3660 tccctcttct cttatggaga tccctcgacc tgcagcccaa gctgtagata agtagcatgg 3720 cgggttaatc attaactaca aggaacccct agtgatggag ttggccactc cctctctgcg 3780 cgctcgctcg ctcactgagg ccgcccgggc tttgcccggg cggcctcagt gagcgagcga 3840 gcgcgcagc 3849 <210> 18 <211> 1674 <212> ADN <213> Secuencia artificial <220> <223> Promotor CAG <400> 18 gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc 60 catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca 120 acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga 180 ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc 240 aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct 300 ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat 360 tagtcatcgc tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct 420 cccccccctc cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga 480 tgggggcggg gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg 540 gcggggcgag gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc 600 cttttatggc gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg 660 gagtcgctgc gttgccttcg ccccgtgccc cgctccgccg ccgcctcgcg ccgcccgccc 720 cggctctgac tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg 780 ggctgtaatt agcgcttggt ttaatgacgg cttgtttctt ttctgtggct gcgtgaaagc 840 cttgaggggc tccgggaggg ccctttgtgc ggggggagcg gctcgggggg tgcgtgcgtg 900 tgtgtgtgcg tggggagcgc cgcgtgcggc tccgcgctgc ccggcggctg tgagcgctgc 960 gggcgcggcg cggggctttg tgcgctccgc agtgtgcgcg aggggagcgc ggccgggggc 1020 ggtgccccgc ggtgcggggg gggctgcgag gggaacaaag gctgcgtgcg gggtgtgtgc 1080 gtgggggggt gagcaggggg tgtgggcgcg tcggtcgggc tgcaaccccc cctgcacccc 1140 cctccccgag ttgctgagca cggcccggct tcgggtgcgg ggctccgtac ggggcgtggc 1200 gcggggctcg ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg cggggcgggg 1260 ccgcctcggg ccggggaggg ctcgggggag gggcgcggcg gcccccggag cgccggcggc 1320 tgtcgaggcg cggcgagccg cagccattgc cttttatggt aatcgtgcga gagggcgcag 1380 ggacttcctt tgtcccaaat ctgtgcggag ccgaaatctg ggaggcgccg ccgcaccccc 1440 tctagcgggc gcggggcgaa gcggtgcggc gccggcagga aggaaatggg cggggagggc 1500 cttcgtgcgt cgccgcgccg ccgtcccctt ctccctctcc agcctcgggg ctgtccgcgg 1560 ggggacggct gccttcgggg gggacggggc agggcggggt tcggcttctg gcgtgtgacc 1620 ggcggctcta gagcctctgc taaccatgtt catgccttct tctttttcct acag 1674 <210> 19 <211> 1221 <212> ADN <213> Secuencia artificial <220> <223> Promotor hAAT <400> 19 gatctgatat catcgatgaa ttcgagctcg gtacccggcc gcagatttag gtgacactat 60 agaatatgca tcactagtaa gcttgcgaat tccagtctac agagaggtct ctgacctctg 120 ccccagctcc aaggtcagca ggcagggagg gctgtgtgtt tgctgtttgc tgcttgcaat 180 gtttgcccat tttagggaca tgagtaggct gaagtttgtt cagtgtggac ttcagaggca 240 gcacacaaac agcaagcttg cgaattccag tctacagaga ggtctctgac ctctgcccca 300 gctccaaggt cagcaggcag ggagggctgt gtgtttgctg tttgctgctt gcaatgtttg 360 cccattttag ggacatgagt aggctgaagt ttgttcagtg tggacttcag aggcagcaca 420 caaacagcaa gcttgcgaat tccagtctac agagaggtct ctgacctctg ccccagctcc 480 aaggtcagca ggcagggagg gctgtgtgtt tgctgtttgc tgcttgcaat gtttgcccat 540 tttagggaca tgagtaggct gaagtttgtt cagtgtggac ttcagaggca gcacacaaac 600 agcaagcttt gctctagact ggaattcgtc gacgagctcc ctatagtgag tcgtattaga 660 ggccgactga cccggtaccc ggggatcttg ctaccagtgg aacagccact aaggattctg 720 cagtgagagc agagggccag ctaagtggta ctctcccaga gactgtctga ctcacgccac 780 cccctccacc ttggacacag gacgctgtgg tttctgagcc aggtacaatg actcctttcg 840 gtaagtgcag tggaagctgt acactgccca ggcaaagcgt ccgggcagcg taggcgggcg 900 actcagatcc cagccagtgg acttagcccc tgtttgctcc tccgataact ggggtgacct 960 tggttaatat tcaccagcag cctcccccgt tgcccctctg gatccactgc ttaaatacgg 1020 acgaggacag ggccctgtct cctcagcttc aggcaccacc actgacctgg gacagtgaat 1080 gtccccctga tctgcggccg tgactctctt aaggtagcct tgcagaagtt ggtcgtgagg 1140 cactgggcag gtaagtatca aggttacaag acaggtttaa ggagaccaat agaaactggg 1200 cttgtcgaga cagagaagac t 1221 <210> 20 <211> 22 <212> ADN <213> Secuencia artificial <220> <223> Cebador sentido <400> 20 ccagggaatg tcccacctat tt 22 <210> 21 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Cebador antisentido <400> 21 gtcaggttga cacgaagctg 20 <210> 22 <211> 18 <212> ADN <213> Secuencia artificial <220> <223> Cebador antisentido KO <400> 22 ggaacttcgg ttccggcg 18