LISTA DE SECUENCIAS <110> Omeros Corporation Universidad de Leicester Cummings, W. Jason Demopulos, Gregory A. Dudler, Thomas Schwaeble, Hans-Wilhelm Tjoelker, Larry W. Wood, Christi L. Yabuki, Munehisa <120> Composiciones y métodos de inhibición del MASP-3 para el tratamiento de diversas enfermedades y trastornos <130> MP.1.0254.PCT <150> US 62/478,336 <151> 29-03-2017 <150> US 62/419,420 <151> 08-11-2016 <150> US 62/369,674 <151> 01-08-2016 <160> 313 <170> PatentIn versión 3.5 <210> 1 <211> 3895 <212> ADN <213> Homo Sapiens <400> 1 attccggcac agggacacaa acaagctcac ccaacaaagc caagctggga ggaccaaggc 60 cgggcagccg ggagcaccca aggcaggaaa atgaggtggc tgcttctcta ttatgctctg 120 tgcttctccc tgtcaaaggc ttcagcccac accgtggagc taaacaatat gtttggccag 180 atccagtcgc ctggttatcc agactcctat cccagtgatt cagaggtgac ttggaatatc 240 actgtcccag atgggtttcg gatcaagctt tacttcatgc acttcaactt ggaatcctcc 300 tacctttgtg aatatgacta tgtgaaggta gaaactgagg accaggtgct ggcaaccttc 360 tgtggcaggg agaccacaga cacagagcag actcccggcc aggaggtggt cctctcccct 420 ggctccttca tgtccatcac tttccggtca gatttctcca atgaggagcg tttcacaggc 480 tttgatgccc actacatggc tgtggatgtg gacgagtgca aggagaggga ggacgaggag 540 ctgtcctgtg accactactg ccacaactac attggcggct actactgctc ctgccgcttc 600 ggctacatcc tccacacaga caacaggacc tgccgagtgg agtgcagtga caacctcttc 660 actcaaagga ctggggtgat caccagccct gacttcccaa acccttaccc caagagctct 720 gaatgcctgt ataccatcga gctggaggag ggtttcatgg tcaacctgca gtttgaggac 780 atatttgaca ttgaggacca tcctgaggtg ccctgcccct atgactacat caagatcaaa 840 gttggtccaa aagttttggg gcctttctgt ggagagaaag ccccagaacc catcagcacc 900 cagagccaca gtgtcctgat cctgttccat agtgacaact cgggagagaa ccggggctgg 960 aggctctcat acagggctgc aggaaatgag tgcccagagc tacagcctcc tgtccatggg 1020 aaaatcgagc cctcccaagc caagtatttc ttcaaagacc aagtgctcgt cagctgtgac 1080 acaggctaca aagtgctgaa ggataatgtg gagatggaca cattccagat tgagtgtctg 1140 aaggatggga cgtggagtaa caagattccc acctgtaaaa ttgtagactg tagagcccca 1200 ggagagctgg aacacgggct gatcaccttc tctacaagga acaacctcac cacatacaag 1260 tctgagatca aatactcctg tcaggagccc tattacaaga tgctcaacaa taacacaggt 1320 atatatacct gttctgccca aggagtctgg atgaataaag tattggggag aagcctaccc 1380 acctgccttc cagagtgtgg tcagccctcc cgctccctgc caagcctggt caagaggatc 1440 attgggggcc gaaatgctga gcctggcctc ttcccgtggc aggccctgat agtggtggag 1500 gacacttcga gagtgccaaa tgacaagtgg tttgggagtg gggccctgct ctctgcgtcc 1560 tggatcctca cagcagctca tgtgctgcgc tcccagcgta gagacaccac ggtgatacca 1620 gtctccaagg agcatgtcac cgtctacctg ggcttgcatg atgtgcgaga caaatcgggg 1680 gcagtcaaca gctcagctgc ccgagtggtg ctccacccag acttcaacat ccaaaactac 1740 aaccacgata tagctctggt gcagctgcag gagcctgtgc ccctgggacc ccacgttatg 1800 cctgtctgcc tgccaaggct tgagcctgaa ggcccggccc cccacatgct gggcctggtg 1860 gccggctggg gcatctccaa tcccaatgtg acagtggatg agatcatcag cagtggcaca 1920 cggaccttgt cagatgtcct gcagtatgtc aagttacccg tggtgcctca cgctgagtgc 1980 aaaactagct atgagtcccg ctcgggcaat tacagcgtca cggagaacat gttctgtgct 2040 ggctactacg agggcggcaa agacacgtgc cttggagata gcggtggggc ctttgtcatc 2100 tttgatgact tgagccagcg ctgggtggtg caaggcctgg tgtcctgggg gggacctgaa 2160 gaatgcggca gcaagcaggt ctatggagtc tacacaaagg tctccaatta cgtggactgg 2220 gtgtgggagc agatgggctt accacaaagt gttgtggagc cccaggtgga acggtgagct 2280 gacttacttc ctcggggcct gcctcccctg agcgaagcta caccgcactt ccgacagcac 2340 actccacatt acttatcaga ccatatggaa tggaacacac tgacctagcg gtggcttctc 2400 ctaccgagac agcccccagg accctgagag gcagagtgtg gtatagggaa aaggctccag 2460 gcaggagacc tgtgttcctg agcttgtcca agtctctttc cctgtctggg cctcactcta 2520 ccgagtaata caatgcagga gctcaaccaa ggcctctgtg ccaatcccag cactcctttc 2580 caggccatgc ttcttacccc agtggccttt attcactcct gaccacttat caaacccatc 2640 ggtcctactg ttggtataac tgagcttgga cctgactatt agaaaatggt ttctaacatt 2700 gaactgaatg ccgcatctgt atattttcct gctctgcctt ctgggactag ccttggccta 2760 atccttcctc taggagaaga gcattcaggt tttgggagat ggctcatagc caagcccctc 2820 tctcttagtg tgatcccttg gagcaccttc atgcctgggg tttctctccc aaaagcttct 2880 tgcagtctaa gccttatccc ttatgttccc cattaaagga atttcaaaag acatggagaa 2940 agttgggaag gtttgtgctg actgctggga gcagaatagc cgtgggaggc ccaccaagcc 3000 cttaaattcc cattgtcaac tcagaacaca tttgggccca tatgccaccc tggaacacca 3060 gctgacacca tgggcgtcca cacctgctgc tccagacaag cacaaagcaa tctttcagcc 3120 ttgaaatgta ttatctgaaa ggctacctga agcccaggcc cgaatatggg gacttagtcg 3180 attacctgga aaaagaaaag acccacactg tgtcctgctg tgcttttggg caggaaaatg 3240 gaagaaagag tggggtgggc acattagaag tcacccaaat cctgccaggc tgcctggcat 3300 ccctggggca tgagctgggc ggagaatcca ccccgcagga tgttcagagg gacccactcc 3360 ttcatttttc agagtcaaag gaatcagagg ctcacccatg gcaggcagtg aaaagagcca 3420 ggagtcctgg gttctagtcc ctgctctgcc cccaactggc tgtataacct ttgaaaaatc 3480 attttctttg tctgagtctc tggttctccg tcagcaacag gctggcataa ggtcccctgc 3540 aggttccttc tagctggagc actcagagct tccctgactg ctagcagcct ctctggccct 3600 cacagggctg attgttctcc ttctccctgg agctctctct cctgaaaatc tccatcagag 3660 caaggcagcc agagaagccc ctgagaggga atgattggga agtgtccact ttctcaaccg 3720 gctcatcaaa cacactcctt tgtctatgaa tggcacatgt aaatgatgtt atattttgta 3780 tcttttatat catatgcttc accattctgt aaagggcctc tgcattgttg ctcccatcag 3840 gggtctcaag tggaaataaa ccctcgtgga taaccaaaaa aaaaaaaaaa aaaaa 3895 <210> 2 <211> 728 <212> PRT <213> Homo sapiens <400> 2 Met Arg Trp Leu Leu Leu Tyr Tyr Ala Leu Cys Phe Ser Leu Ser Lys 1 5 10 15 Ala Ser Ala His Thr Val Glu Leu Asn Asn Met Phe Gly Gln Ile Gln 20 25 30 Ser Pro Gly Tyr Pro Asp Ser Tyr Pro Ser Asp Ser Glu Val Thr Trp 35 40 45 Asn Ile Thr Val Pro Asp Gly Phe Arg Ile Lys Leu Tyr Phe Met His 50 55 60 Phe Asn Leu Glu Ser Ser Tyr Leu Cys Glu Tyr Asp Tyr Val Lys Val 65 70 75 80 Glu Thr Glu Asp Gln Val Leu Ala Thr Phe Cys Gly Arg Glu Thr Thr 85 90 95 Asp Thr Glu Gln Thr Pro Gly Gln Glu Val Val Leu Ser Pro Gly Ser 100 105 110 Phe Met Ser Ile Thr Phe Arg Ser Asp Phe Ser Asn Glu Glu Arg Phe 115 120 125 Thr Gly Phe Asp Ala His Tyr Met Ala Val Asp Val Asp Glu Cys Lys 130 135 140 Glu Arg Glu Asp Glu Glu Leu Ser Cys Asp His Tyr Cys His Asn Tyr 145 150 155 160 Ile Gly Gly Tyr Tyr Cys Ser Cys Arg Phe Gly Tyr Ile Leu His Thr 165 170 175 Asp Asn Arg Thr Cys Arg Val Glu Cys Ser Asp Asn Leu Phe Thr Gln 180 185 190 Arg Thr Gly Val Ile Thr Ser Pro Asp Phe Pro Asn Pro Tyr Pro Lys 195 200 205 Ser Ser Glu Cys Leu Tyr Thr Ile Glu Leu Glu Glu Gly Phe Met Val 210 215 220 Asn Leu Gln Phe Glu Asp Ile Phe Asp Ile Glu Asp His Pro Glu Val 225 230 235 240 Pro Cys Pro Tyr Asp Tyr Ile Lys Ile Lys Val Gly Pro Lys Val Leu 245 250 255 Gly Pro Phe Cys Gly Glu Lys Ala Pro Glu Pro Ile Ser Thr Gln Ser 260 265 270 His Ser Val Leu Ile Leu Phe His Ser Asp Asn Ser Gly Glu Asn Arg 275 280 285 Gly Trp Arg Leu Ser Tyr Arg Ala Ala Gly Asn Glu Cys Pro Glu Leu 290 295 300 Gln Pro Pro Val His Gly Lys Ile Glu Pro Ser Gln Ala Lys Tyr Phe 305 310 315 320 Phe Lys Asp Gln Val Leu Val Ser Cys Asp Thr Gly Tyr Lys Val Leu 325 330 335 Lys Asp Asn Val Glu Met Asp Thr Phe Gln Ile Glu Cys Leu Lys Asp 340 345 350 Gly Thr Trp Ser Asn Lys Ile Pro Thr Cys Lys Ile Val Asp Cys Arg 355 360 365 Ala Pro Gly Glu Leu Glu His Gly Leu Ile Thr Phe Ser Thr Arg Asn 370 375 380 Asn Leu Thr Thr Tyr Lys Ser Glu Ile Lys Tyr Ser Cys Gln Glu Pro 385 390 395 400 Tyr Tyr Lys Met Leu Asn Asn Asn Thr Gly Ile Tyr Thr Cys Ser Ala 405 410 415 Gln Gly Val Trp Met Asn Lys Val Leu Gly Arg Ser Leu Pro Thr Cys 420 425 430 Leu Pro Glu Cys Gly Gln Pro Ser Arg Ser Leu Pro Ser Leu Val Lys 435 440 445 Arg Ile Ile Gly Gly Arg Asn Ala Glu Pro Gly Leu Phe Pro Trp Gln 450 455 460 Ala Leu Ile Val Val Glu Asp Thr Ser Arg Val Pro Asn Asp Lys Trp 465 470 475 480 Phe Gly Ser Gly Ala Leu Leu Ser Ala Ser Trp Ile Leu Thr Ala Ala 485 490 495 His Val Leu Arg Ser Gln Arg Arg Asp Thr Thr Val Ile Pro Val Ser 500 505 510 Lys Glu His Val Thr Val Tyr Leu Gly Leu His Asp Val Arg Asp Lys 515 520 525 Ser Gly Ala Val Asn Ser Ser Ala Ala Arg Val Val Leu His Pro Asp 530 535 540 Phe Asn Ile Gln Asn Tyr Asn His Asp Ile Ala Leu Val Gln Leu Gln 545 550 555 560 Glu Pro Val Pro Leu Gly Pro His Val Met Pro Val Cys Leu Pro Arg 565 570 575 Leu Glu Pro Glu Gly Pro Ala Pro His Met Leu Gly Leu Val Ala Gly 580 585 590 Trp Gly Ile Ser Asn Pro Asn Val Thr Val Asp Glu Ile Ile Ser Ser 595 600 605 Gly Thr Arg Thr Leu Ser Asp Val Leu Gln Tyr Val Lys Leu Pro Val 610 615 620 Val Pro His Ala Glu Cys Lys Thr Ser Tyr Glu Ser Arg Ser Gly Asn 625 630 635 640 Tyr Ser Val Thr Glu Asn Met Phe Cys Ala Gly Tyr Tyr Glu Gly Gly 645 650 655 Lys Asp Thr Cys Leu Gly Asp Ser Gly Gly Ala Phe Val Ile Phe Asp 660 665 670 Asp Leu Ser Gln Arg Trp Val Val Gln Gly Leu Val Ser Trp Gly Gly 675 680 685 Pro Glu Glu Cys Gly Ser Lys Gln Val Tyr Gly Val Tyr Thr Lys Val 690 695 700 Ser Asn Tyr Val Asp Trp Val Trp Glu Gln Met Gly Leu Pro Gln Ser 705 710 715 720 Val Val Glu Pro Gln Val Glu Arg 725 <210> 3 <211> 733 <212> PRT <213> Mus musculus <400> 3 Met Arg Phe Leu Ser Phe Trp Arg Leu Leu Leu Tyr His Ala Leu Cys 1 5 10 15 Leu Ala Leu Pro Glu Val Ser Ala His Thr Val Glu Leu Asn Glu Met 20 25 30 Phe Gly Gln Ile Gln Ser Pro Gly Tyr Pro Asp Ser Tyr Pro Ser Asp 35 40 45 Ser Glu Val Thr Trp Asn Ile Thr Val Pro Glu Gly Phe Arg Ile Lys 50 55 60 Leu Tyr Phe Met His Phe Asn Leu Glu Ser Ser Tyr Leu Cys Glu Tyr 65 70 75 80 Asp Tyr Val Lys Val Glu Thr Glu Asp Gln Val Leu Ala Thr Phe Cys 85 90 95 Gly Arg Glu Thr Thr Asp Thr Glu Gln Thr Pro Gly Gln Glu Val Val 100 105 110 Leu Ser Pro Gly Thr Phe Met Ser Val Thr Phe Arg Ser Asp Phe Ser 115 120 125 Asn Glu Glu Arg Phe Thr Gly Phe Asp Ala His Tyr Met Ala Val Asp 130 135 140 Val Asp Glu Cys Lys Glu Arg Glu Asp Glu Glu Leu Ser Cys Asp His 145 150 155 160 Tyr Cys His Asn Tyr Ile Gly Gly Tyr Tyr Cys Ser Cys Arg Phe Gly 165 170 175 Tyr Ile Leu His Thr Asp Asn Arg Thr Cys Arg Val Glu Cys Ser Gly 180 185 190 Asn Leu Phe Thr Gln Arg Thr Gly Thr Ile Thr Ser Pro Asp Tyr Pro 195 200 205 Asn Pro Tyr Pro Lys Ser Ser Glu Cys Ser Tyr Thr Ile Asp Leu Glu 210 215 220 Glu Gly Phe Met Val Ser Leu Gln Phe Glu Asp Ile Phe Asp Ile Glu 225 230 235 240 Asp His Pro Glu Val Pro Cys Pro Tyr Asp Tyr Ile Lys Ile Lys Ala 245 250 255 Gly Ser Lys Val Trp Gly Pro Phe Cys Gly Glu Lys Ser Pro Glu Pro 260 265 270 Ile Ser Thr Gln Thr His Ser Val Gln Ile Leu Phe Arg Ser Asp Asn 275 280 285 Ser Gly Glu Asn Arg Gly Trp Arg Leu Ser Tyr Arg Ala Ala Gly Asn 290 295 300 Glu Cys Pro Lys Leu Gln Pro Pro Val Tyr Gly Lys Ile Glu Pro Ser 305 310 315 320 Gln Ala Val Tyr Ser Phe Lys Asp Gln Val Leu Val Ser Cys Asp Thr 325 330 335 Gly Tyr Lys Val Leu Lys Asp Asn Gly Val Met Asp Thr Phe Gln Ile 340 345 350 Glu Cys Leu Lys Asp Gly Ala Trp Ser Asn Lys Ile Pro Thr Cys Lys 355 360 365 Ile Val Asp Cys Gly Ala Pro Ala Gly Leu Lys His Gly Leu Val Thr 370 375 380 Phe Ser Thr Arg Asn Asn Leu Thr Thr Tyr Lys Ser Glu Ile Arg Tyr 385 390 395 400 Ser Cys Gln Gln Pro Tyr Tyr Lys Met Leu His Asn Thr Thr Gly Val 405 410 415 Tyr Thr Cys Ser Ala His Gly Thr Trp Thr Asn Glu Val Leu Lys Arg 420 425 430 Ser Leu Pro Thr Cys Leu Pro Val Cys Gly Gln Pro Ser Arg Ala Leu 435 440 445 Pro Asn Leu Val Lys Arg Ile Ile Gly Gly Arg Asn Ala Glu Leu Gly 450 455 460 Leu Phe Pro Trp Gln Ala Leu Ile Val Val Glu Asp Thr Ser Arg Val 465 470 475 480 Pro Asn Asp Lys Trp Phe Gly Ser Gly Ala Leu Leu Ser Glu Ser Trp 485 490 495 Ile Leu Thr Ala Ala His Val Leu Arg Ser Gln Arg Arg Asp Asn Thr 500 505 510 Val Ile Pro Val Ser Lys Glu His Val Thr Val Tyr Leu Gly Leu His 515 520 525 Asp Val Arg Asp Lys Ser Gly Ala Val Asn Ser Ser Ala Ala Arg Val 530 535 540 Ile Leu His Pro Asp Phe Asn Ile Gln Asn Tyr Asn His Asp Ile Ala 545 550 555 560 Leu Val Gln Leu Gln Lys Pro Val Pro Leu Gly Ala His Val Met Pro 565 570 575 Ile Cys Leu Pro Arg Pro Glu Pro Glu Gly Pro Ala Pro His Met Leu 580 585 590 Gly Leu Val Ala Gly Trp Gly Ile Ser Asn Pro Asn Val Thr Val Asp 595 600 605 Glu Ile Ile Leu Ser Gly Thr Arg Thr Leu Ser Asp Val Leu Gln Tyr 610 615 620 Val Lys Leu Pro Val Val Ser His Ala Glu Cys Lys Ala Ser Tyr Glu 625 630 635 640 Ser Arg Ser Gly Asn Tyr Ser Val Thr Glu Asn Met Phe Cys Ala Gly 645 650 655 Tyr Tyr Glu Gly Gly Lys Asp Thr Cys Leu Gly Asp Ser Gly Gly Ala 660 665 670 Phe Val Ile Phe Asp Glu Met Ser Gln His Trp Val Ala Gln Gly Leu 675 680 685 Val Ser Trp Gly Gly Pro Glu Glu Cys Gly Ser Lys Gln Val Tyr Gly 690 695 700 Val Tyr Thr Lys Val Ser Asn Tyr Val Asp Trp Leu Trp Glu Glu Met 705 710 715 720 Asn Ser Pro Arg Ala Val Arg Asp Leu Gln Val Glu Arg 725 730 <210> 4 <211> 733 <212> PRT <213> Rattus norvegicus <400> 4 Met Arg Phe Leu Ser Phe Arg Arg Leu Leu Leu Tyr His Val Leu Cys 1 5 10 15 Leu Thr Leu Thr Glu Val Ser Ala His Thr Val Glu Leu Asn Glu Met 20 25 30 Phe Gly Gln Ile Gln Ser Pro Gly Tyr Pro Asp Ser Tyr Pro Ser Asp 35 40 45 Ser Glu Val Thr Trp Asn Ile Thr Val Pro Glu Gly Phe Arg Val Gln 50 55 60 Leu Tyr Phe Met His Phe Asn Leu Glu Ser Ser Tyr Leu Cys Glu Tyr 65 70 75 80 Asp Tyr Val Lys Val Glu Thr Glu Asp Gln Val Leu Ala Thr Phe Cys 85 90 95 Gly Arg Glu Thr Thr Asp Thr Glu Gln Thr Pro Gly Gln Glu Val Val 100 105 110 Leu Ser Pro Gly Ser Phe Met Ser Val Thr Phe Arg Ser Asp Phe Ser 115 120 125 Asn Glu Glu Arg Phe Thr Gly Phe Asp Ala His Tyr Met Ala Val Asp 130 135 140 Val Asp Glu Cys Lys Glu Arg Glu Asp Glu Glu Leu Ser Cys Asp His 145 150 155 160 Tyr Cys His Asn Tyr Ile Gly Gly Tyr Tyr Cys Ser Cys Arg Phe Gly 165 170 175 Tyr Ile Leu His Thr Asp Asn Arg Thr Cys Arg Val Glu Cys Ser Gly 180 185 190 Asn Leu Phe Thr Gln Arg Thr Gly Thr Ile Thr Ser Pro Asp Tyr Pro 195 200 205 Asn Pro Tyr Pro Lys Ser Ser Glu Cys Ser Tyr Thr Ile Asp Leu Glu 210 215 220 Glu Gly Phe Met Val Thr Leu Gln Phe Glu Asp Ile Phe Asp Ile Glu 225 230 235 240 Asp His Pro Glu Val Pro Cys Pro Tyr Asp Tyr Ile Lys Ile Lys Ala 245 250 255 Gly Ser Lys Val Trp Gly Pro Phe Cys Gly Glu Lys Ser Pro Glu Pro 260 265 270 Ile Ser Thr Gln Ser His Ser Ile Gln Ile Leu Phe Arg Ser Asp Asn 275 280 285 Ser Gly Glu Asn Arg Gly Trp Arg Leu Ser Tyr Arg Ala Ala Gly Asn 290 295 300 Glu Cys Pro Lys Leu Gln Pro Pro Val Tyr Gly Lys Ile Glu Pro Ser 305 310 315 320 Gln Ala Val Tyr Ser Phe Lys Asp Gln Val Leu Ile Ser Cys Asp Thr 325 330 335 Gly Tyr Lys Val Leu Lys Asp Asn Glu Val Met Asp Thr Phe Gln Ile 340 345 350 Glu Cys Leu Lys Asp Gly Ala Trp Ser Asn Lys Ile Pro Thr Cys Lys 355 360 365 Ile Val Asp Cys Gly Val Pro Ala Val Leu Lys His Gly Leu Val Thr 370 375 380 Phe Ser Thr Arg Asn Asn Leu Thr Thr Tyr Lys Ser Glu Ile Arg Tyr 385 390 395 400 Ser Cys Gln Gln Pro Tyr Tyr Lys Met Leu His Asn Thr Thr Gly Val 405 410 415 Tyr Thr Cys Ser Ala His Gly Thr Trp Thr Asn Glu Val Leu Lys Arg 420 425 430 Ser Leu Pro Thr Cys Leu Pro Val Cys Gly Gln Pro Ser Arg Ala Leu 435 440 445 Pro Asn Leu Val Lys Arg Ile Ile Gly Gly Arg Asn Ala Glu Leu Gly 450 455 460 Leu Phe Pro Trp Gln Ala Leu Ile Val Val Glu Asp Thr Ser Arg Ile 465 470 475 480 Pro Asn Asp Lys Trp Phe Gly Ser Gly Ala Leu Leu Ser Glu Ser Trp 485 490 495 Ile Leu Thr Ala Ala His Val Leu Arg Ser Gln Arg Arg Asp Asn Thr 500 505 510 Val Ile Pro Val Ser Lys Asp His Val Thr Val Tyr Leu Gly Leu His 515 520 525 Asp Val Arg Asp Lys Ser Gly Ala Val Asn Ser Ser Ala Ala Arg Val 530 535 540 Val Leu His Pro Asp Phe Asn Ile Gln Asn Tyr Asn His Asp Ile Ala 545 550 555 560 Leu Val Gln Leu Gln Glu Pro Val Pro Leu Gly Ala His Val Met Pro 565 570 575 Ile Cys Leu Pro Arg Pro Glu Pro Glu Gly Pro Ala Pro His Met Leu 580 585 590 Gly Leu Val Ala Gly Trp Gly Ile Ser Asn Pro Asn Val Thr Val Asp 595 600 605 Glu Ile Ile Ile Ser Gly Thr Arg Thr Leu Ser Asp Val Leu Gln Tyr 610 615 620 Val Lys Leu Pro Val Val Ser His Ala Glu Cys Lys Ala Ser Tyr Glu 625 630 635 640 Ser Arg Ser Gly Asn Tyr Ser Val Thr Glu Asn Met Phe Cys Ala Gly 645 650 655 Tyr Tyr Glu Gly Gly Lys Asp Thr Cys Leu Gly Asp Ser Gly Gly Ala 660 665 670 Phe Val Ile Phe Asp Glu Met Ser Gln Arg Trp Val Ala Gln Gly Leu 675 680 685 Val Ser Trp Gly Gly Pro Glu Glu Cys Gly Ser Lys Gln Val Tyr Gly 690 695 700 Val Tyr Thr Lys Val Ser Asn Tyr Val Asp Trp Leu Leu Glu Glu Met 705 710 715 720 Asn Ser Pro Arg Gly Val Arg Glu Leu Gln Val Glu Arg 725 730 <210> 5 <211> 730 <212> PRT <213> Gallus gallus <400> 5 Met Arg Tyr Pro Leu Ala Trp Ser Met Cys Ala Trp Leu Leu Gly Val 1 5 10 15 Val Gly Ala Val Glu Leu Thr Asp Met Phe Gly Glu Ile Arg Ser Pro 20 25 30 Asn Phe Pro Asp Ser Tyr Pro Ser Asp Ser Glu Val Thr Trp Asn Ile 35 40 45 Ser Val Pro Glu Gly Phe Lys Ile Lys Leu Tyr Tyr Met His Phe Asp 50 55 60 Leu Glu Ser Ser Tyr Leu Cys Glu Tyr Asp Tyr Val Lys Ile Glu Ala 65 70 75 80 Glu Asp Gln Glu Leu Ala Thr Phe Cys Gly Arg Glu Thr Thr Asp Thr 85 90 95 Glu Gln Ala Pro Gly Gln Gln Val Ile Leu Ser Pro Gly Pro Tyr Met 100 105 110 Gly Leu Thr Phe Arg Ser Asp Phe Ser Asn Glu Glu Arg Phe Thr Gly 115 120 125 Phe Asp Ala His Tyr Thr Ala Val Asp Val Asp Glu Cys Leu Glu Lys 130 135 140 Ser Asp Glu Glu Leu Ala Cys Asp His Tyr Cys His Asn Tyr Ile Gly 145 150 155 160 Gly Tyr Tyr Cys Ser Cys Arg Phe Gly Tyr Ile Leu His Ser Asp Asn 165 170 175 Arg Thr Cys Lys Val Glu Cys Ser Asp Asn Leu Tyr Thr Gln Arg Ser 180 185 190 Gly Val Val Thr Ser Ala Asp Phe Pro Ser Pro Tyr Pro Lys Ser Ser 195 200 205 Asp Cys Leu Tyr Arg Ile Glu Leu Glu Asp Gly Phe Phe Ile Thr Leu 210 215 220 Ser Phe Glu Asp Ser Phe Asp Val Glu Asp His Pro Glu Val Thr Cys 225 230 235 240 Pro Tyr Asp Tyr Ile Lys Ile Lys Ala Gly Gln Arg Glu Phe Gly Pro 245 250 255 Phe Cys Gly Glu Lys Ser Pro Gly Arg Ile Glu Thr Gln Thr Asn Ser 260 265 270 Val Gln Ile Leu Phe His Ser Asp Asn Ser Gly Glu Asn Arg Gly Trp 275 280 285 Lys Leu Ser Tyr Thr Ala Ile Gly Asn Pro Cys Pro Leu Val Gln Pro 290 295 300 Pro Ile Asn Gly Lys Ile Glu Pro Ser Gln Ala Lys Tyr Thr Phe Lys 305 310 315 320 Asp Gln Val Val Ile Ser Cys Asn Thr Gly Tyr Lys Val Leu Lys Asp 325 330 335 Asn Leu Glu Ser Asp Ser Phe Gln Ile Glu Cys Leu Lys Asp Gly Thr 340 345 350 Trp Ser Asn Lys Ile Pro Ile Cys Lys Ile Ala Asp Cys Gln Ala Pro 355 360 365 Pro Glu Leu Glu His Gly Phe Val Thr Phe Leu Ser Arg Asn Asn Leu 370 375 380 Thr Thr Tyr Arg Ala Arg Ile Gln Tyr His Cys Gln His Pro Tyr Tyr 385 390 395 400 His Met Ala Pro Asn Ser Thr Ala Thr Tyr Thr Cys Asp Ala Ser Gly 405 410 415 Val Trp Arg Ser Glu Glu Leu Gly Thr Val Leu Pro Ser Cys Arg Pro 420 425 430 Val Cys Gly Arg Pro Val Arg Ala Leu Pro Gly Ile Ile Lys Arg Ile 435 440 445 Ile Gly Gly Arg Asn Ala Glu Pro Gly Phe Phe Pro Trp Gln Ala Leu 450 455 460 Ile Val Val Glu Asp Met Ser Arg Val Pro Asn Asp Lys Trp Phe Gly 465 470 475 480 Ser Gly Ala Leu Leu Ser Asp Ser Trp Val Leu Thr Ala Ala His Val 485 490 495 Leu Arg Ser Gln Arg Arg Asp Lys Thr Val Ile Pro Val Ser Lys Glu 500 505 510 His Val Thr Val Tyr Leu Ala Leu His Asp Val Arg Asn Lys Leu Glu 515 520 525 Ala Val Asn Arg Thr Val Glu Arg Ile Ile Leu His Glu Asp Phe Asp 530 535 540 Ile Gln Asn Tyr Asn His Asp Ile Ala Leu Val Lys Leu Lys Glu Lys 545 550 555 560 Val Thr Met Gly Asn Tyr Val Met Pro Ile Cys Leu Pro Gln Phe Glu 565 570 575 His Glu Leu Glu Gly Pro His Pro Asn Thr Leu Gly Leu Val Ala Gly 580 585 590 Trp Gly Ile Ser Asn Pro Asn Ile Thr Val Asp Glu Ile Ile Ser Ser 595 600 605 Gly Met Arg Thr Leu Ser Asp Ile Leu Gln Tyr Val Lys Leu Pro Val 610 615 620 Val Leu His Ala Glu Cys Lys Thr Ser Tyr Glu Ser Arg Ser Gly Asn 625 630 635 640 Tyr Ser Val Thr Glu Asn Met Phe Cys Ala Gly Tyr Tyr Glu Gly Gly 645 650 655 Lys Asp Thr Cys Leu Gly Asp Ser Gly Gly Ala Phe Val Ile Gln Asp 660 665 670 Pro Gly Thr Arg Arg Trp Val Ala Gln Gly Leu Val Ser Trp Gly Gly 675 680 685 Pro Glu Glu Cys Gly Ser Lys Gln Val Tyr Gly Val Tyr Thr Lys Val 690 695 700 Ser Asn Tyr Val Asp Trp Val Glu Lys Asn Thr Gly Ser Ser Glu Arg 705 710 715 720 Trp Thr Phe Leu Asp Pro Glu Leu Glu Arg 725 730 <210> 6 <211> 728 <212> PRT <213> Oryctolagus cuniculus <400> 6 Met Arg Trp Leu Leu Leu Cys His Ala Leu Cys Phe Ser Leu Leu Lys 1 5 10 15 Ala Ser Ala His Thr Val Glu Leu Asn Asp Met Phe Gly Gln Ile Gln 20 25 30 Ser Pro Gly Tyr Pro Asp Ser Tyr Pro Ser Asp Ser Glu Val Thr Trp 35 40 45 Asn Ile Thr Val Pro Glu Gly Phe Arg Ile Lys Leu Tyr Phe Met His 50 55 60 Phe Asn Leu Glu Ser Ser Tyr Leu Cys Glu Tyr Asp Tyr Val Lys Val 65 70 75 80 Glu Thr Glu Asp Gln Val Leu Ala Thr Phe Cys Gly Arg Glu Thr Thr 85 90 95 Asp Thr Glu Gln Thr Pro Gly Gln Glu Val Val Leu Ser Pro Gly Ser 100 105 110 Phe Met Ser Ile Thr Phe Arg Ser Asp Phe Ser Asn Glu Glu Arg Phe 115 120 125 Thr Gly Phe Asp Ala His Tyr Met Ala Val Asp Val Asp Glu Cys Lys 130 135 140 Glu Arg Glu Asp Glu Glu Leu Ser Cys Asp His Tyr Cys His Asn Tyr 145 150 155 160 Ile Gly Gly Tyr Tyr Cys Ser Cys Arg Phe Gly Tyr Ile Leu His Thr 165 170 175 Asp Asn Arg Thr Cys Arg Val Glu Cys Ser Asp Asn Leu Phe Thr Gln 180 185 190 Arg Thr Gly Val Ile Thr Ser Pro Asp Tyr Pro Asn Pro Tyr Pro Lys 195 200 205 Ser Ser Glu Cys Phe Tyr Thr Ile Glu Leu Glu Glu Gly Phe Met Ile 210 215 220 Ser Leu Gln Phe Glu Asp Ile Phe Asp Ile Glu Asp His Pro Glu Val 225 230 235 240 Pro Cys Pro Tyr Asp Tyr Ile Lys Ile Lys Val Gly Glu Asn Val Trp 245 250 255 Gly Pro Tyr Cys Gly Glu Lys Ala Pro Glu Ala Ile Ser Thr Gln Ser 260 265 270 His Ser Val Gln Ile Leu Phe Arg Ser Asp Asn Ser Gly Glu Asn Arg 275 280 285 Gly Trp Arg Leu Ser Tyr Arg Ala Ala Gly Asn Glu Cys Ser Glu Leu 290 295 300 Gln Pro Pro Asp Gln Gly Lys Ile Glu Pro Leu Gln Ala Lys Tyr Phe 305 310 315 320 Phe Lys Asp Gln Val Leu Val Ser Cys Asp Thr Gly Tyr Lys Val Leu 325 330 335 Lys Asp Asp Val Glu Met Asp Thr Phe Gln Ile Glu Cys Leu Lys Asp 340 345 350 Gly Thr Trp Ser Asn Lys Ile Pro Thr Cys Lys Met Val Asp Cys Gly 355 360 365 Val Pro Ala Glu Leu Glu His Gly Leu Leu Thr Phe Ser Ser Arg Ser 370 375 380 Asn Leu Thr Thr Tyr Ala Ser Glu Val Thr Tyr Ser Cys Gln Gln Pro 385 390 395 400 Tyr Tyr Arg Leu Leu His Asn Val Ser Gly Val Tyr Thr Cys Ser Ala 405 410 415 Gln Gly Ile Trp Thr Asn Glu Val Leu Gly Arg Ser Leu Pro Thr Cys 420 425 430 Ile Pro Val Cys Gly Gln Pro Ser Arg Ser Leu Pro Ser Leu Ile Lys 435 440 445 Arg Ile Ile Gly Gly Arg Asn Ala Glu Pro Gly Leu Phe Pro Trp Gln 450 455 460 Ala Leu Ile Val Val Glu Asp Thr Ser Arg Val Pro Asn Asp Lys Trp 465 470 475 480 Phe Gly Ser Gly Ala Leu Leu Ser Glu Ser Trp Ile Leu Thr Ala Ala 485 490 495 His Val Leu Arg Ser Gln Arg Arg Asp Asn Thr Val Ile Pro Val Ser 500 505 510 Arg Glu His Val Thr Val Tyr Leu Gly Leu His Asp Val Arg Asp Lys 515 520 525 Ser Gly Ala Val Asn Ser Ser Ala Ala Arg Val Leu Leu His Pro Asp 530 535 540 Phe Asn Ile Gln Asn Tyr Asn His Asp Ile Ala Leu Val Gln Leu Gln 545 550 555 560 Glu Pro Val Pro Leu Gly Pro His Val Met Pro Ile Cys Leu Pro Arg 565 570 575 Pro Glu Pro Glu Gly Pro Ala Pro Tyr Met Leu Gly Leu Val Ala Gly 580 585 590 Trp Gly Ile Ser Asn Pro Asn Val Thr Val Asp Glu Ile Ile Ser Ser 595 600 605 Gly Thr Arg Thr Leu Ser Asp Ile Leu Gln Tyr Val Lys Leu Pro Val 610 615 620 Val Pro His Ala Glu Cys Lys Thr Ser Tyr Glu Ser Arg Ser Gly Asn 625 630 635 640 Tyr Ser Val Thr Glu Asn Met Phe Cys Ala Gly Tyr Tyr Glu Gly Gly 645 650 655 Lys Asp Thr Cys Leu Gly Asp Ser Gly Gly Ala Phe Val Ile Leu Asp 660 665 670 Asp Leu Ser Arg Arg Trp Val Ala Gln Gly Leu Val Ser Trp Gly Gly 675 680 685 Pro Glu Glu Cys Gly Ser Lys Gln Val Tyr Gly Val Tyr Thr Lys Val 690 695 700 Ser Asn Tyr Val Asp Trp Val Trp Glu Gln Met Gly Ser Pro Gln Gly 705 710 715 720 Leu Gly Glu Leu Gln Val Glu Arg 725 <210> 7 <211> 728 <212> PRT <213> Mono Cynomolgus <400> 7 Met Arg Trp Leu Leu Leu Tyr His Ala Leu Cys Phe Ser Leu Ser Lys 1 5 10 15 Ala Ser Ala His Thr Val Glu Leu Asn Asp Met Phe Gly Gln Ile Gln 20 25 30 Ser Pro Gly Tyr Pro Asp Ser Tyr Pro Ser Asp Ser Glu Val Thr Trp 35 40 45 Asn Ile Thr Val Pro Asp Gly Phe Arg Ile Lys Leu Tyr Phe Met His 50 55 60 Phe Asn Leu Glu Ser Ser Tyr Leu Cys Glu Tyr Asp Tyr Val Lys Val 65 70 75 80 Glu Thr Glu Asp Gln Val Leu Ala Thr Phe Cys Gly Arg Glu Thr Thr 85 90 95 Asp Thr Glu Gln Thr Pro Gly Gln Glu Val Val Leu Ser Pro Gly Ser 100 105 110 Phe Met Ser Ile Thr Phe Arg Ser Asp Phe Ser Asn Glu Glu Arg Phe 115 120 125 Thr Gly Phe Asp Ala His Tyr Met Ala Val Asp Val Asp Glu Cys Lys 130 135 140 Glu Arg Glu Asp Glu Glu Leu Ser Cys Asp His Tyr Cys His Asn Tyr 145 150 155 160 Ile Gly Gly Tyr Tyr Cys Ser Cys Arg Phe Gly Tyr Ile Leu His Thr 165 170 175 Asp Asn Arg Thr Cys Arg Val Glu Cys Ser Asp Asn Leu Phe Thr Gln 180 185 190 Arg Thr Gly Val Ile Thr Ser Pro Asp Phe Pro Asn Pro Tyr Pro Lys 195 200 205 Ser Ser Glu Cys Leu Tyr Thr Ile Glu Leu Glu Glu Gly Phe Met Val 210 215 220 Asn Leu Gln Phe Glu Asp Ile Phe Asp Ile Glu Asp His Pro Glu Val 225 230 235 240 Pro Cys Pro Tyr Asp Tyr Ile Lys Ile Lys Val Gly Pro Lys Val Leu 245 250 255 Gly Pro Phe Cys Gly Glu Lys Ala Pro Glu Pro Ile Asn Thr Gln Ser 260 265 270 His Ser Val Leu Ile Leu Phe His Ser Asp Asn Ser Gly Glu Asn Arg 275 280 285 Gly Trp Arg Leu Ser Tyr Arg Ala Ala Gly Asn Glu Cys Pro Glu Leu 290 295 300 Gln Pro Pro Val His Gly Lys Ile Glu Pro Ser Gln Ala Lys Tyr Ser 305 310 315 320 Phe Lys Asp Gln Val Leu Ile Ser Cys Asp Thr Gly Tyr Lys Val Leu 325 330 335 Lys Asp Asn Val Glu Met Asp Thr Phe Gln Ile Glu Cys Leu Lys Asp 340 345 350 Gly Thr Trp Ser Asn Lys Ile Pro Thr Cys Lys Ile Val Asp Cys Arg 355 360 365 Ala Pro Gly Glu Leu Glu His Gly Leu Val Thr Phe Ser Thr Arg Asn 370 375 380 Asn Leu Thr Thr Tyr Lys Ser Glu Ile Arg Tyr Ser Cys Gln Glu Pro 385 390 395 400 Tyr Tyr Lys Met Leu Asn Asn Ile Thr Gly Ile Tyr Thr Cys Ser Ala 405 410 415 Gln Gly Val Trp Met Asn Lys Val Leu Gly Arg Ser Leu Pro Thr Cys 420 425 430 Leu Pro Glu Cys Gly Gln Pro Ser Arg Ser Leu Pro Ser Leu Val Lys 435 440 445 Arg Ile Ile Gly Gly Arg Asn Ala Glu Pro Gly Leu Phe Pro Trp Gln 450 455 460 Ala Leu Ile Val Val Glu Asp Thr Ser Arg Val Pro Asn Asp Lys Trp 465 470 475 480 Phe Gly Ser Gly Ala Leu Leu Ser Glu Ser Trp Ile Leu Thr Ala Ala 485 490 495 His Val Leu Arg Ser Gln Arg Arg Asp Thr Thr Val Ile Pro Val Ser 500 505 510 Lys Glu His Val Thr Val Tyr Leu Gly Leu His Asp Val Arg Asp Lys 515 520 525 Ser Gly Ala Val Asn Ser Ser Ala Ala Arg Val Val Leu His Pro Asp 530 535 540 Phe Asn Ile Gln Asn Tyr Asn His Asp Ile Ala Leu Val Gln Leu Gln 545 550 555 560 Glu Pro Val Pro Leu Gly Pro His Val Met Pro Val Cys Leu Pro Arg 565 570 575 Leu Glu Pro Glu Gly Pro Ser Pro His Met Leu Gly Leu Val Ala Gly 580 585 590 Trp Gly Ile Ser Asn Pro Asn Val Thr Val Asp Glu Ile Ile Ser Ser 595 600 605 Gly Thr Arg Thr Leu Ser Asp Val Leu Gln Tyr Val Lys Leu Pro Val 610 615 620 Val Pro His Ala Glu Cys Lys Thr Ser Tyr Glu Ser Arg Ser Gly Asn 625 630 635 640 Tyr Ser Val Thr Glu Asn Met Phe Cys Ala Gly Tyr Tyr Glu Gly Gly 645 650 655 Lys Asp Thr Cys Leu Gly Asp Ser Gly Gly Ala Phe Val Ile Leu Asp 660 665 670 Asp Leu Ser Gln Arg Trp Val Val Gln Gly Leu Val Ser Trp Gly Gly 675 680 685 Pro Glu Glu Cys Gly Ser Lys Gln Val Tyr Gly Val Tyr Thr Lys Val 690 695 700 Ser Asn Tyr Val Asp Trp Val Trp Glu Gln Met Gly Ser Pro Gln Gly 705 710 715 720 Arg Ala Pro Gly Gly Thr Val Ser 725 <210> 8 <211> 699 <212> PRT <213> Homo sapiens <400> 8 Met Arg Trp Leu Leu Leu Tyr Tyr Ala Leu Cys Phe Ser Leu Ser Lys 1 5 10 15 Ala Ser Ala His Thr Val Glu Leu Asn Asn Met Phe Gly Gln Ile Gln 20 25 30 Ser Pro Gly Tyr Pro Asp Ser Tyr Pro Ser Asp Ser Glu Val Thr Trp 35 40 45 Asn Ile Thr Val Pro Asp Gly Phe Arg Ile Lys Leu Tyr Phe Met His 50 55 60 Phe Asn Leu Glu Ser Ser Tyr Leu Cys Glu Tyr Asp Tyr Val Lys Val 65 70 75 80 Glu Thr Glu Asp Gln Val Leu Ala Thr Phe Cys Gly Arg Glu Thr Thr 85 90 95 Asp Thr Glu Gln Thr Pro Gly Gln Glu Val Val Leu Ser Pro Gly Ser 100 105 110 Phe Met Ser Ile Thr Phe Arg Ser Asp Phe Ser Asn Glu Glu Arg Phe 115 120 125 Thr Gly Phe Asp Ala His Tyr Met Ala Val Asp Val Asp Glu Cys Lys 130 135 140 Glu Arg Glu Asp Glu Glu Leu Ser Cys Asp His Tyr Cys His Asn Tyr 145 150 155 160 Ile Gly Gly Tyr Tyr Cys Ser Cys Arg Phe Gly Tyr Ile Leu His Thr 165 170 175 Asp Asn Arg Thr Cys Arg Val Glu Cys Ser Asp Asn Leu Phe Thr Gln 180 185 190 Arg Thr Gly Val Ile Thr Ser Pro Asp Phe Pro Asn Pro Tyr Pro Lys 195 200 205 Ser Ser Glu Cys Leu Tyr Thr Ile Glu Leu Glu Glu Gly Phe Met Val 210 215 220 Asn Leu Gln Phe Glu Asp Ile Phe Asp Ile Glu Asp His Pro Glu Val 225 230 235 240 Pro Cys Pro Tyr Asp Tyr Ile Lys Ile Lys Val Gly Pro Lys Val Leu 245 250 255 Gly Pro Phe Cys Gly Glu Lys Ala Pro Glu Pro Ile Ser Thr Gln Ser 260 265 270 His Ser Val Leu Ile Leu Phe His Ser Asp Asn Ser Gly Glu Asn Arg 275 280 285 Gly Trp Arg Leu Ser Tyr Arg Ala Ala Gly Asn Glu Cys Pro Glu Leu 290 295 300 Gln Pro Pro Val His Gly Lys Ile Glu Pro Ser Gln Ala Lys Tyr Phe 305 310 315 320 Phe Lys Asp Gln Val Leu Val Ser Cys Asp Thr Gly Tyr Lys Val Leu 325 330 335 Lys Asp Asn Val Glu Met Asp Thr Phe Gln Ile Glu Cys Leu Lys Asp 340 345 350 Gly Thr Trp Ser Asn Lys Ile Pro Thr Cys Lys Ile Val Asp Cys Arg 355 360 365 Ala Pro Gly Glu Leu Glu His Gly Leu Ile Thr Phe Ser Thr Arg Asn 370 375 380 Asn Leu Thr Thr Tyr Lys Ser Glu Ile Lys Tyr Ser Cys Gln Glu Pro 385 390 395 400 Tyr Tyr Lys Met Leu Asn Asn Asn Thr Gly Ile Tyr Thr Cys Ser Ala 405 410 415 Gln Gly Val Trp Met Asn Lys Val Leu Gly Arg Ser Leu Pro Thr Cys 420 425 430 Leu Pro Val Cys Gly Leu Pro Lys Phe Ser Arg Lys Leu Met Ala Arg 435 440 445 Ile Phe Asn Gly Arg Pro Ala Gln Lys Gly Thr Thr Pro Trp Ile Ala 450 455 460 Met Leu Ser His Leu Asn Gly Gln Pro Phe Cys Gly Gly Ser Leu Leu 465 470 475 480 Gly Ser Ser Trp Ile Val Thr Ala Ala His Cys Leu His Gln Ser Leu 485 490 495 Asp Pro Lys Asp Pro Thr Leu Arg Asp Ser Asp Leu Leu Ser Pro Ser 500 505 510 Asp Phe Lys Ile Ile Leu Gly Lys His Trp Arg Leu Arg Ser Asp Glu 515 520 525 Asn Glu Gln His Leu Gly Val Lys His Thr Thr Leu His Pro Lys Tyr 530 535 540 Asp Pro Asn Thr Phe Glu Asn Asp Val Ala Leu Val Glu Leu Leu Glu 545 550 555 560 Ser Pro Val Leu Asn Ala Phe Val Met Pro Ile Cys Leu Pro Glu Gly 565 570 575 Pro Gln Gln Glu Gly Ala Met Val Ile Val Ser Gly Trp Gly Lys Gln 580 585 590 Phe Leu Gln Arg Phe Pro Glu Thr Leu Met Glu Ile Glu Ile Pro Ile 595 600 605 Val Asp His Ser Thr Cys Gln Lys Ala Tyr Ala Pro Leu Lys Lys Lys 610 615 620 Val Thr Arg Asp Met Ile Cys Ala Gly Glu Lys Glu Gly Gly Lys Asp 625 630 635 640 Ala Cys Ser Gly Asp Ser Gly Gly Pro Met Val Thr Leu Asn Arg Glu 645 650 655 Arg Gly Gln Trp Tyr Leu Val Gly Thr Val Ser Trp Gly Asp Asp Cys 660 665 670 Gly Lys Lys Asp Arg Tyr Gly Val Tyr Ser Tyr Ile His His Asn Lys 675 680 685 Asp Trp Ile Gln Arg Val Thr Gly Val Arg Asn 690 695 <210> 9 <211> 12 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 9 Val Leu Arg Ser Gln Arg Arg Asp Thr Thr Val Ile 1 5 10 <210> 10 <211> 15 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 10 Thr Ala Ala His Val Leu Arg Ser Gln Arg Arg Asp Thr Thr Val 1 5 10 15 <210> 11 <211> 15 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 11 Asp Phe Asn Ile Gln Asn Tyr Asn His Asp Ile Ala Leu Val Gln 1 5 10 15 <210> 12 <211> 13 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 12 Pro His Ala Glu Cys Lys Thr Ser Tyr Glu Ser Arg Ser 1 5 10 <210> 13 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 13 Gly Asn Tyr Ser Val Thr Glu Asn Met Phe Cys 1 5 10 <210> 14 <211> 10 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 14 Val Ser Asn Tyr Val Asp Trp Val Trp Glu 1 5 10 <210> 15 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 15 Val Leu Arg Ser Gln Arg Arg Asp Thr Thr Val 1 5 10 <210> 16 <211> 13 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 16 Glu Cys Gly Gln Pro Ser Arg Ser Leu Pro Ser Leu Val 1 5 10 <210> 17 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 17 Arg Asn Ala Glu Pro Gly Leu Phe Pro Trp Gln 1 5 10 <210> 18 <211> 15 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 18 Lys Trp Phe Gly Ser Gly Ala Leu Leu Ser Ala Ser Trp Ile Leu 1 5 10 15 <210> 19 <211> 10 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 19 Glu His Val Thr Val Tyr Leu Gly Leu His 1 5 10 <210> 20 <211> 10 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 20 Pro Val Pro Leu Gly Pro His Val Met Pro 1 5 10 <210> 21 <211> 7 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 21 Ala Pro His Met Leu Gly Leu 1 5 <210> 22 <211> 10 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 22 Ser Asp Val Leu Gln Tyr Val Lys Leu Pro 1 5 10 <210> 23 <211> 12 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 23 Ala Phe Val Ile Phe Asp Asp Leu Ser Gln Arg Trp 1 5 10 <210> 24 <211> 114 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 24 Gln Val Gln Leu Lys Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Asp 20 25 30 Asp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Trp Ile Tyr Pro Arg Asp Asp Arg Thr Lys Tyr Asn Asp Lys Phe 50 55 60 Lys Asp Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr 65 70 75 80 Met Asp Leu His Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 85 90 95 Ser Ser Leu Glu Asp Thr Tyr Trp Gly Gln Gly Thr Leu Val Ala Val 100 105 110 Ser Ser <210> 25 <211> 114 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 25 Gln Val Gln Leu Lys Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Asn 20 25 30 Asp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Trp Ile Tyr Pro Arg Asp Gly Ser Ile Lys Tyr Asn Glu Lys Phe 50 55 60 Thr Asp Lys Ala Thr Leu Thr Val Asp Val Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu His Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 85 90 95 Ser Gly Val Glu Asp Ser Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 100 105 110 Ser Ser <210> 26 <211> 114 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 26 Gln Val Gln Leu Lys Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Asn 20 25 30 Asp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Trp Ile Tyr Pro Arg Asp Gly Thr Thr Lys Tyr Asn Glu Glu Phe 50 55 60 Thr Asp Lys Ala Thr Leu Thr Val Asp Val Ser Ser Ser Thr Ala Phe 65 70 75 80 Met Glu Leu His Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 85 90 95 Ser Ser Val Glu Asp Ser Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 100 105 110 Ser Ser <210> 27 <211> 114 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 27 Gln Val Gln Leu Lys Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Asn 20 25 30 Asp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Trp Ile Tyr Pro Arg Asp Gly Thr Thr Lys Tyr Asn Glu Lys Phe 50 55 60 Thr Asp Lys Ala Thr Leu Thr Val Asp Val Ser Ser Ser Thr Ala Phe 65 70 75 80 Met Glu Leu His Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 85 90 95 Ser Ser Val Glu Asp Ser Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 100 105 110 Ser Ser <210> 28 <211> 116 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 28 Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 1 5 10 15 Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 20 25 30 Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 35 40 45 Gly Trp Ile Asn Thr Tyr Ser Gly Val Pro Thr Tyr Ala Asp Asp Phe 50 55 60 Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Arg Thr Pro Tyr 65 70 75 80 Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 85 90 95 Ala Arg Gly Gly Glu Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 100 105 110 Thr Val Ser Ser 115 <210> 29 <211> 116 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 29 Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Thr Pro Gly Glu 1 5 10 15 Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 20 25 30 Gly Ile Thr Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 35 40 45 Gly Trp Ile Asn Thr Tyr Ser Gly Val Pro Thr Tyr Ala Asp Asp Phe 50 55 60 Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 65 70 75 80 Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Thr Thr Tyr Phe Cys 85 90 95 Thr Arg Gly Gly Asp Ala Leu Asp Tyr Trp Gly Gln Gly Thr Ser Val 100 105 110 Thr Val Ser Ser 115 <210> 30 <211> 113 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 30 Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Leu Ser Cys Lys Ala Thr Gly Tyr Thr Phe Thr Gly Lys 20 25 30 Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Leu Pro Gly Thr Gly Ser Thr Asn Tyr Asn Glu Lys Phe 50 55 60 Lys Gly Lys Ala Thr Phe Thr Ala Asp Ser Ser Ser Asn Thr Ala Tyr 65 70 75 80 Met Gln Leu Ser Ser Leu Thr Thr Glu Asp Ser Ala Met Tyr Tyr Cys 85 90 95 Leu Arg Ser Glu Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser 100 105 110 Ser <210> 31 <211> 113 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 31 Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Leu Ala Cys Lys Ala Thr Gly Tyr Thr Phe Thr Gly Tyr 20 25 30 Trp Ile Glu Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Glu Met Leu Pro Gly Ser Gly Ser Thr His Tyr Asn Glu Lys Phe 50 55 60 Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 65 70 75 80 Met Gln Leu Ser Gly Leu Thr Thr Glu Asp Ser Ala Ile Tyr Tyr Cys 85 90 95 Val Arg Ser Ile Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 100 105 110 Ser <210> 32 <211> 125 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 32 Gln Val Gln Leu Lys Gln Ser Gly Pro Glu Leu Ala Arg Pro Trp Ala 1 5 10 15 Ser Val Lys Ile Ser Cys Gln Ala Phe Tyr Thr Phe Ser Arg Arg Val 20 25 30 His Phe Ala Ile Arg Asp Thr Asn Tyr Trp Met Gln Trp Val Lys Gln 35 40 45 Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn 50 55 60 Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr 65 70 75 80 Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr 85 90 95 Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Ser Gly Ser His Tyr Phe 100 105 110 Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 115 120 125 <210> 33 <211> 123 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 33 Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Leu Thr Asp Tyr 20 25 30 Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 35 40 45 Gly Asp Val Asn Pro Asn Asn Asp Gly Thr Thr Tyr Asn Gln Lys Phe 50 55 60 Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Thr Ala Ser 65 70 75 80 Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 85 90 95 Ala Ile Cys Pro Phe Tyr Tyr Leu Gly Lys Gly Thr His Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Ser Leu Thr Val Ser Ser 115 120 <210> 34 <211> 124 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 34 Glu Val Gln Leu Gln Gln Ser Gly Pro Val Leu Val Lys Pro Gly Ala 1 5 10 15 Ser Gly Lys Met Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Asp Tyr 20 25 30 Tyr Met Ile Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 35 40 45 Gly Val Ile Lys Ile Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 50 55 60 Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Pro Ser Leu Tyr Asp Tyr Asp Pro Tyr Trp Tyr Phe Asp 100 105 110 Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 35 <211> 120 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 35 Gln Val Gln Leu Lys Gln Ser Gly Thr Glu Leu Met Lys Pro Gly Ala 1 5 10 15 Ser Val Asn Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ala Tyr 20 25 30 Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Leu Pro Gly Ser Gly Thr Thr Asn Tyr Asn Glu Asn Phe 50 55 60 Lys Asp Arg Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 65 70 75 80 Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 85 90 95 Ala Arg Ser Tyr Tyr Tyr Ala Ser Arg Trp Phe Ala Phe Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 36 <211> 120 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 36 Glu Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Trp Ile Thr Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Asp Ile Tyr Pro Gly Ser Gly Ser Thr Asn Tyr Asn Glu Lys Phe 50 55 60 Lys Ser Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Arg Arg Tyr Tyr Ala Thr Ala Trp Phe Ala Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 37 <211> 120 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 37 Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 1 5 10 15 Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 20 25 30 Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Ala Arg Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe 50 55 60 Lys Gly Lys Ala Thr Leu Thr Ala Glu Lys Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 85 90 95 Ala Arg Asn Tyr Tyr Ile Ser Ser Pro Trp Phe Ala Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 38 <211> 120 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 38 Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Val Thr Pro Gly Ala 1 5 10 15 Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 20 25 30 Pro Ile Glu Trp Met Lys Gln Asn His Gly Lys Ser Leu Glu Trp Ile 35 40 45 Gly Asn Phe His Pro Tyr Asn Asp Asp Thr Lys Tyr Asn Glu Lys Phe 50 55 60 Lys Gly Lys Ala Thr Leu Thr Val Glu Lys Ser Ser Asn Thr Val Tyr 65 70 75 80 Leu Glu Leu Ser Arg Leu Thr Ser Asp Asp Ser Ala Val Tyr Phe Cys 85 90 95 Ala Arg Arg Val Tyr Tyr Ser Tyr Phe Trp Phe Gly Tyr Trp Gly His 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 39 <211> 120 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 39 Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 20 25 30 Pro Ile Glu Trp Met Lys Gln Asn His Gly Lys Ser Leu Glu Trp Ile 35 40 45 Gly Asn Phe His Pro Tyr Asn Gly Asp Ser Lys Tyr Asn Glu Lys Phe 50 55 60 Lys Gly Lys Ala Thr Leu Thr Val Glu Lys Ser Ser Ser Thr Val Tyr 65 70 75 80 Leu Glu Leu Ser Arg Leu Pro Ser Ala Asp Ser Ala Ile Tyr Tyr Cys 85 90 95 Ala Arg Arg His Tyr Ala Ala Ser Pro Trp Phe Ala His Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 40 <211> 113 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 40 Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 1 5 10 15 Glu Lys Val Thr Met Thr Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 20 25 30 Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 35 40 45 Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 50 55 60 Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr 65 70 75 80 Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 85 90 95 Ser Tyr Asn Leu Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 110 Arg <210> 41 <211> 113 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 41 Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 1 5 10 15 Glu Arg Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Ile Ser 20 25 30 Arg Thr Arg Lys Asn Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln 35 40 45 Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 50 55 60 Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 65 70 75 80 Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 85 90 95 Ser Tyr Asn Leu Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 110 Arg <210> 42 <211> 113 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 42 Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 1 5 10 15 Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Ile Ser 20 25 30 Arg Thr Arg Lys Asn Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln 35 40 45 Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 50 55 60 Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 65 70 75 80 Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 85 90 95 Ser Tyr Asn Leu Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 110 Arg <210> 43 <211> 113 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 43 Asp Val Leu Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 1 5 10 15 Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 20 25 30 Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 35 40 45 Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 50 55 60 Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 85 90 95 Thr His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 110 Arg <210> 44 <211> 113 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 44 Asp Ile Val Met Thr Gln Ala Pro Leu Thr Leu Ser Val Thr Ile Gly 1 5 10 15 Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 20 25 30 Asp Gly Lys Thr Tyr Leu Ser Trp Leu Leu Gln Arg Pro Gly Gln Ser 35 40 45 Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 50 55 60 Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 85 90 95 Thr His Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 110 Arg <210> 45 <211> 113 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 45 Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 1 5 10 15 Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 20 25 30 Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 35 40 45 Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 50 55 60 Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 65 70 75 80 Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 85 90 95 Ser Tyr Asn Ile Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 110 Arg <210> 46 <211> 113 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 46 Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 1 5 10 15 Glu Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Gln Ser 20 25 30 Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 85 90 95 Thr His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 110 Arg <210> 47 <211> 108 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 47 Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Ser 20 25 30 Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 35 40 45 Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser 65 70 75 80 Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser Asn Ser Trp Pro Tyr 85 90 95 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 100 105 <210> 48 <211> 108 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 48 Asp Ile Gln Met Thr Gln Thr Pro Ala Ser Leu Ser Ala Ser Leu Gly 1 5 10 15 Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Phe 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Asn Gly Thr Val Lys Leu Leu Val 35 40 45 Phe Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Ala Glu His Ser Leu Thr Ile Ser Asn Leu Glu Gln 65 70 75 80 Glu Asp Val Ala Thr Tyr Phe Cys Gln Gln Gly Phe Thr Leu Pro Trp 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 49 <211> 113 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 49 Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 1 5 10 15 Asp Gln Ala Ser Phe Ser Cys Arg Ser Ser Gln Ser Leu Ile His Ser 20 25 30 Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 85 90 95 Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 110 Arg <210> 50 <211> 108 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 50 Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Ile Gly 1 5 10 15 Asp Arg Val Ser Val Thr Cys Arg Ala Ser Gln Asn Val Gly Pro Asn 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 35 40 45 Tyr Ser Ala Ser Tyr Arg Phe Ser Gly Val Pro Asp Arg Phe Thr Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 65 70 75 80 Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Arg Tyr Pro Phe 85 90 95 Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg 100 105 <210> 51 <211> 108 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 51 Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 1 5 10 15 Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 20 25 30 Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 35 40 45 Ser Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Met Gln Ser 65 70 75 80 Glu Asp Val Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 85 90 95 Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 100 105 <210> 52 <211> 108 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 52 Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 1 5 10 15 Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Pro Asn 20 25 30 Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 35 40 45 Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 65 70 75 80 Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Arg Tyr Pro Leu 85 90 95 Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 100 105 <210> 53 <211> 110 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 53 Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 1 5 10 15 Asp Arg Val Asn Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr His 20 25 30 Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 35 40 45 Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 65 70 75 80 Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Arg 85 90 95 Ala Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 100 105 110 <210> 54 <211> 108 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 54 Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 1 5 10 15 Asp Arg Val Asn Val Thr Cys Lys Ala Ser Gln Asn Val Gly Pro Thr 20 25 30 Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 35 40 45 Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val His Ser 65 70 75 80 Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Phe 85 90 95 Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg 100 105 <210> 55 <211> 30 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 55 Gln Val Gln Leu Lys Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 20 25 30 <210> 56 <211> 5 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 56 Thr Asp Asp Ile Asn 1 5 <210> 57 <211> 14 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 57 Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 1 5 10 <210> 58 <211> 17 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 58 Trp Ile Tyr Pro Arg Asp Asp Arg Thr Lys Tyr Asn Asp Lys Phe Lys 1 5 10 15 Asp <210> 59 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 59 Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr Met Asp 1 5 10 15 Leu His Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ser Ser 20 25 30 <210> 60 <211> 5 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 60 Leu Glu Asp Thr Tyr 1 5 <210> 61 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 61 Trp Gly Gln Gly Thr Leu Val Ala Val Ser Ser 1 5 10 <210> 62 <211> 5 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 62 Ser Asn Asp Ile Asn 1 5 <210> 63 <211> 17 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 63 Trp Ile Tyr Pro Arg Asp Gly Ser Ile Lys Tyr Asn Glu Lys Phe Thr 1 5 10 15 Asp <210> 64 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 64 Lys Ala Thr Leu Thr Val Asp Val Ser Ser Ser Thr Ala Tyr Met Glu 1 5 10 15 Leu His Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ser Gly 20 25 30 <210> 65 <211> 5 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 65 Val Glu Asp Ser Tyr 1 5 <210> 66 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 66 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 1 5 10 <210> 67 <211> 17 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 67 Trp Ile Tyr Pro Arg Asp Gly Thr Thr Lys Tyr Asn Glu Glu Phe Thr 1 5 10 15 Asp <210> 68 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 68 Lys Ala Thr Leu Thr Val Asp Val Ser Ser Ser Thr Ala Phe Met Glu 1 5 10 15 Leu His Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ser Ser 20 25 30 <210> 69 <211> 17 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 69 Trp Ile Tyr Pro Arg Asp Gly Thr Thr Lys Tyr Asn Glu Lys Phe Thr 1 5 10 15 Asp <210> 70 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 70 Lys Ala Thr Leu Thr Val Asp Val Ser Ser Ser Thr Ala Phe Met Glu 1 5 10 15 Leu His Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ser Ser 20 25 30 <210> 71 <211> 30 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 71 Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 1 5 10 15 Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr 20 25 30 <210> 72 <211> 5 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 72 Ser Tyr Gly Met Ser 1 5 <210> 73 <211> 14 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 73 Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Lys Trp Met Gly 1 5 10 <210> 74 <211> 17 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 74 Trp Ile Asn Thr Tyr Ser Gly Val Pro Thr Tyr Ala Asp Asp Phe Lys 1 5 10 15 Gly <210> 75 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 75 Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Arg Thr Pro Tyr Leu Gln 1 5 10 15 Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 20 25 30 <210> 76 <211> 7 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 76 Gly Gly Glu Ala Met Asp Tyr 1 5 <210> 77 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 77 Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 1 5 10 <210> 78 <211> 30 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 78 Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Thr Pro Gly Glu 1 5 10 15 Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr 20 25 30 <210> 79 <211> 5 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 79 Ser Tyr Gly Ile Thr 1 5 <210> 80 <211> 14 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 80 Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met Gly 1 5 10 <210> 81 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 81 Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr Leu Gln 1 5 10 15 Ile Asn Asn Leu Lys Asn Glu Asp Thr Thr Thr Tyr Phe Cys Thr Arg 20 25 30 <210> 82 <211> 7 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 82 Gly Gly Asp Ala Leu Asp Tyr 1 5 <210> 83 <211> 30 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 83 Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Leu Ser Cys Lys Ala Thr Gly Tyr Thr Phe Thr 20 25 30 <210> 84 <211> 5 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 84 Gly Lys Trp Ile Glu 1 5 <210> 85 <211> 14 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 85 Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile Gly 1 5 10 <210> 86 <211> 17 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 86 Glu Ile Leu Pro Gly Thr Gly Ser Thr Asn Tyr Asn Glu Lys Phe Lys 1 5 10 15 Gly <210> 87 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 87 Lys Ala Thr Phe Thr Ala Asp Ser Ser Ser Asn Thr Ala Tyr Met Gln 1 5 10 15 Leu Ser Ser Leu Thr Thr Glu Asp Ser Ala Met Tyr Tyr Cys Leu Arg 20 25 30 <210> 88 <211> 4 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 88 Ser Glu Asp Val 1 <210> 89 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 89 Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser 1 5 10 <210> 90 <211> 30 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 90 Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Leu Ala Cys Lys Ala Thr Gly Tyr Thr Phe Thr 20 25 30 <210> 91 <211> 5 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 91 Gly Tyr Trp Ile Glu 1 5 <210> 92 <211> 14 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 92 Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 1 5 10 <210> 93 <211> 17 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 93 Glu Met Leu Pro Gly Ser Gly Ser Thr His Tyr Asn Glu Lys Phe Lys 1 5 10 15 Gly <210> 94 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 94 Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr Met Gln 1 5 10 15 Leu Ser Gly Leu Thr Thr Glu Asp Ser Ala Ile Tyr Tyr Cys Val Arg 20 25 30 <210> 95 <211> 4 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 95 Ser Ile Asp Tyr 1 <210> 96 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 96 Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 1 5 10 <210> 97 <211> 30 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 97 Glu Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 20 25 30 <210> 98 <211> 5 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 98 Ser Tyr Trp Ile Thr 1 5 <210> 99 <211> 17 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 99 Asp Ile Tyr Pro Gly Ser Gly Ser Thr Asn Tyr Asn Glu Lys Phe Lys 1 5 10 15 Ser <210> 100 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 100 Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr Met Gln 1 5 10 15 Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg 20 25 30 <210> 101 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 101 Arg Arg Tyr Tyr Ala Thr Ala Trp Phe Ala Tyr 1 5 10 <210> 102 <211> 30 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 102 Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 1 5 10 15 Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 20 25 30 <210> 103 <211> 5 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 103 Asp Tyr Tyr Ile Asn 1 5 <210> 104 <211> 14 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 104 Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Ala 1 5 10 <210> 105 <211> 17 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 105 Arg Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe Lys 1 5 10 15 Gly <210> 106 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 106 Lys Ala Thr Leu Thr Ala Glu Lys Ser Ser Ser Thr Ala Tyr Met Gln 1 5 10 15 Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg 20 25 30 <210> 107 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 107 Asn Tyr Tyr Ile Ser Ser Pro Trp Phe Ala Tyr 1 5 10 <210> 108 <211> 30 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 108 Gln Val Gln Leu Lys Gln Ser Gly Pro Glu Leu Ala Arg Pro Trp Ala 1 5 10 15 Ser Val Lys Ile Ser Cys Gln Ala Phe Tyr Thr Phe Ser Arg 20 25 30 <210> 109 <211> 14 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 109 Arg Val His Phe Ala Ile Arg Asp Thr Asn Tyr Trp Met Gln 1 5 10 <210> 110 <211> 17 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 110 Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys 1 5 10 15 Gly <210> 111 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 111 Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 1 5 10 15 Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Ser 20 25 30 <210> 112 <211> 7 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 112 Gly Ser His Tyr Phe Asp Tyr 1 5 <210> 113 <211> 30 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 113 Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Val Thr Pro Gly Ala 1 5 10 15 Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 20 25 30 <210> 114 <211> 5 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 114 Thr Tyr Pro Ile Glu 1 5 <210> 115 <211> 14 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 115 Trp Met Lys Gln Asn His Gly Lys Ser Leu Glu Trp Ile Gly 1 5 10 <210> 116 <211> 17 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 116 Asn Phe His Pro Tyr Asn Asp Asp Thr Lys Tyr Asn Glu Lys Phe Lys 1 5 10 15 Gly <210> 117 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 117 Lys Ala Thr Leu Thr Val Glu Lys Ser Ser Asn Thr Val Tyr Leu Glu 1 5 10 15 Leu Ser Arg Leu Thr Ser Asp Asp Ser Ala Val Tyr Phe Cys Ala Arg 20 25 30 <210> 118 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 118 Arg Val Tyr Tyr Ser Tyr Phe Trp Phe Gly Tyr 1 5 10 <210> 119 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 119 Trp Gly His Gly Thr Leu Val Thr Val Ser Ser 1 5 10 <210> 120 <211> 30 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 120 Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 20 25 30 <210> 121 <211> 17 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 121 Asn Phe His Pro Tyr Asn Gly Asp Ser Lys Tyr Asn Glu Lys Phe Lys 1 5 10 15 Gly <210> 122 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 122 Lys Ala Thr Leu Thr Val Glu Lys Ser Ser Ser Thr Val Tyr Leu Glu 1 5 10 15 Leu Ser Arg Leu Pro Ser Ala Asp Ser Ala Ile Tyr Tyr Cys Ala Arg 20 25 30 <210> 123 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 123 Arg His Tyr Ala Ala Ser Pro Trp Phe Ala His 1 5 10 <210> 124 <211> 30 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 124 Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Leu Thr 20 25 30 <210> 125 <211> 5 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 125 Asp Tyr Tyr Met Asn 1 5 <210> 126 <211> 14 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 126 Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly 1 5 10 <210> 127 <211> 17 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 127 Asp Val Asn Pro Asn Asn Asp Gly Thr Thr Tyr Asn Gln Lys Phe Lys 1 5 10 15 Gly <210> 128 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 128 Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Thr Ala Ser Met Glu 1 5 10 15 Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Ile 20 25 30 <210> 129 <211> 14 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 129 Cys Pro Phe Tyr Tyr Leu Gly Lys Gly Thr His Phe Asp Tyr 1 5 10 <210> 130 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 130 Trp Gly Gln Gly Thr Ser Leu Thr Val Ser Ser 1 5 10 <210> 131 <211> 30 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 131 Glu Val Gln Leu Gln Gln Ser Gly Pro Val Leu Val Lys Pro Gly Ala 1 5 10 15 Ser Gly Lys Met Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr 20 25 30 <210> 132 <211> 5 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 132 Asp Tyr Tyr Met Ile 1 5 <210> 133 <211> 17 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 133 Val Ile Lys Ile Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys 1 5 10 15 Gly <210> 134 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 134 Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu 1 5 10 15 Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg 20 25 30 <210> 135 <211> 15 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 135 Gly Pro Ser Leu Tyr Asp Tyr Asp Pro Tyr Trp Tyr Phe Asp Val 1 5 10 15 <210> 136 <211> 30 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 136 Gln Val Gln Leu Lys Gln Ser Gly Thr Glu Leu Met Lys Pro Gly Ala 1 5 10 15 Ser Val Asn Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 20 25 30 <210> 137 <211> 5 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 137 Ala Tyr Trp Ile Glu 1 5 <210> 138 <211> 17 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 138 Glu Ile Leu Pro Gly Ser Gly Thr Thr Asn Tyr Asn Glu Asn Phe Lys 1 5 10 15 Asp <210> 139 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 139 Arg Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr Met Gln 1 5 10 15 Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys Ala Arg 20 25 30 <210> 140 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 140 Ser Tyr Tyr Tyr Ala Ser Arg Trp Phe Ala Phe 1 5 10 <210> 141 <211> 23 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 141 Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 1 5 10 15 Glu Lys Val Thr Met Thr Cys 20 <210> 142 <211> 17 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 142 Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 1 5 10 15 Ala <210> 143 <211> 15 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 143 Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 1 5 10 15 <210> 144 <211> 7 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 144 Trp Ala Ser Thr Arg Glu Ser 1 5 <210> 145 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 145 Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Ser 1 5 10 15 Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys 20 25 30 <210> 146 <211> 8 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 146 Lys Gln Ser Tyr Asn Leu Tyr Thr 1 5 <210> 147 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 147 Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 1 5 10 <210> 148 <211> 23 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 148 Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 1 5 10 15 Glu Arg Val Thr Met Ser Cys 20 <210> 149 <211> 17 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 149 Lys Ser Ser Gln Ser Leu Leu Ile Ser Arg Thr Arg Lys Asn Tyr Leu 1 5 10 15 Ser <210> 150 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 150 Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr 1 5 10 15 Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys 20 25 30 <210> 151 <211> 23 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 151 Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 1 5 10 15 Glu Lys Val Thr Met Ser Cys 20 <210> 152 <211> 23 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 152 Asp Val Leu Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 1 5 10 15 Gln Pro Ala Ser Ile Ser Cys 20 <210> 153 <211> 16 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 153 Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn 1 5 10 15 <210> 154 <211> 15 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 154 Trp Leu Leu Gln Arg Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr 1 5 10 15 <210> 155 <211> 7 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 155 Leu Val Ser Lys Leu Asp Ser 1 5 <210> 156 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 156 Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr 1 5 10 15 Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys 20 25 30 <210> 157 <211> 9 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 157 Trp Gln Gly Thr His Phe Pro Trp Thr 1 5 <210> 158 <211> 23 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 158 Asp Ile Val Met Thr Gln Ala Pro Leu Thr Leu Ser Val Thr Ile Gly 1 5 10 15 Gln Pro Ala Ser Ile Ser Cys 20 <210> 159 <211> 16 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 159 Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Ser 1 5 10 15 <210> 160 <211> 9 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 160 Trp Gln Gly Thr His Phe Pro Tyr Thr 1 5 <210> 161 <211> 8 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 161 Lys Gln Ser Tyr Asn Ile Pro Thr 1 5 <210> 162 <211> 23 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 162 Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 1 5 10 15 Glu Gln Ala Ser Ile Ser Cys 20 <210> 163 <211> 16 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 163 Arg Ser Ser Gln Ser Leu Val Gln Ser Asn Gly Asn Thr Tyr Leu His 1 5 10 15 <210> 164 <211> 15 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 164 Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 1 5 10 15 <210> 165 <211> 7 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 165 Lys Val Ser Asn Arg Phe Ser 1 5 <210> 166 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 166 Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 1 5 10 15 Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys 20 25 30 <210> 167 <211> 9 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 167 Ser Gln Ser Thr His Val Pro Pro Thr 1 5 <210> 168 <211> 23 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 168 Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 1 5 10 15 Asp Arg Val Ser Ile Thr Cys 20 <210> 169 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 169 Lys Ala Ser Gln Asn Val Gly Thr Ala Val Ala 1 5 10 <210> 170 <211> 15 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 170 Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Ser 1 5 10 15 <210> 171 <211> 7 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 171 Ser Ala Ser Asn Arg Tyr Thr 1 5 <210> 172 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 172 Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr 1 5 10 15 Leu Thr Ile Ser Asn Met Gln Ser Glu Asp Val Ala Asp Tyr Phe Cys 20 25 30 <210> 173 <211> 9 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 173 Gln Gln Tyr Asn Ser Tyr Pro Leu Thr 1 5 <210> 174 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 174 Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 1 5 10 <210> 175 <211> 23 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 175 Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 1 5 10 15 Asp Arg Val Ser Val Thr Cys 20 <210> 176 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 176 Lys Ala Ser Gln Asn Val Gly Pro Asn Val Ala 1 5 10 <210> 177 <211> 15 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 177 Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile Tyr 1 5 10 15 <210> 178 <211> 7 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 178 Ser Ala Ser Tyr Arg Tyr Ser 1 5 <210> 179 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 179 Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr 1 5 10 15 Leu Thr Ile Ser Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys 20 25 30 <210> 180 <211> 9 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 180 Gln Gln Tyr Asn Arg Tyr Pro Leu Thr 1 5 <210> 181 <211> 23 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 181 Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Val Ser Phe Ser Cys 20 <210> 182 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 182 Arg Ala Ser Gln Ser Ile Gly Thr Ser Ile His 1 5 10 <210> 183 <211> 15 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 183 Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile Lys 1 5 10 15 <210> 184 <211> 7 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 184 Tyr Ala Ser Glu Ser Ile Ser 1 5 <210> 185 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 185 Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 1 5 10 15 Leu Ser Ile Asn Ser Val Glu Ser Glu Asp Ile Ala Asp Tyr Tyr Cys 20 25 30 <210> 186 <211> 9 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 186 Gln Gln Ser Asn Ser Trp Pro Tyr Thr 1 5 <210> 187 <211> 23 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 187 Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 1 5 10 15 Asp Arg Val Asn Val Thr Cys 20 <210> 188 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 188 Lys Ala Ser Gln Asn Val Gly Thr His Val Ala 1 5 10 <210> 189 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 189 Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr 1 5 10 15 Leu Thr Ile Ser Asn Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe Cys 20 25 30 <210> 190 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 190 Gln Gln Tyr Asn Ser Tyr Pro Arg Ala Leu Thr 1 5 10 <210> 191 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 191 Lys Ala Ser Gln Asn Val Gly Pro Thr Val Ala 1 5 10 <210> 192 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 192 Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr 1 5 10 15 Leu Thr Ile Ser Asn Val His Ser Glu Asp Leu Ala Glu Tyr Phe Cys 20 25 30 <210> 193 <211> 9 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 193 Gln Gln Tyr Asn Ser Tyr Pro Phe Thr 1 5 <210> 194 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 194 Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg 1 5 10 <210> 195 <211> 23 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 195 Asp Ile Gln Met Thr Gln Thr Pro Ala Ser Leu Ser Ala Ser Leu Gly 1 5 10 15 Asp Arg Val Thr Ile Ser Cys 20 <210> 196 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 196 Arg Ala Ser Gln Asp Ile Ser Asn Phe Leu Asn 1 5 10 <210> 197 <211> 15 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 197 Trp Tyr Gln Gln Lys Pro Asn Gly Thr Val Lys Leu Leu Val Phe 1 5 10 15 <210> 198 <211> 7 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 198 Tyr Thr Ser Arg Leu His Ser 1 5 <210> 199 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 199 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Ala Glu His Ser 1 5 10 15 Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Val Ala Thr Tyr Phe Cys 20 25 30 <210> 200 <211> 9 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 200 Gln Gln Gly Phe Thr Leu Pro Trp Thr 1 5 <210> 201 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 201 Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 1 5 10 <210> 202 <211> 23 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 202 Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 1 5 10 15 Asp Gln Ala Ser Phe Ser Cys 20 <210> 203 <211> 16 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 203 Arg Ser Ser Gln Ser Leu Ile His Ser Asn Gly Asn Thr Tyr Leu His 1 5 10 15 <210> 204 <211> 9 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 204 Ser Gln Ser Thr His Val Pro Trp Thr 1 5 <210> 205 <211> 23 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 205 Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Ile Gly 1 5 10 15 Asp Arg Val Ser Val Thr Cys 20 <210> 206 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 206 Arg Ala Ser Gln Asn Val Gly Pro Asn Leu Ala 1 5 10 <210> 207 <211> 7 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 207 Ser Ala Ser Tyr Arg Phe Ser 1 5 <210> 208 <211> 9 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 208 Gln Gln Tyr Asn Arg Tyr Pro Phe Thr 1 5 <210> 209 <211> 5 <212> PRT <213> Secuencia artificial <220> <223> Sintético <220> <221> VARIANTE <222> (1)..(1) <223> donde Xaa en la posición 1 es S o T <220> <221> VARIANTE <222> (2)..(2) <223> donde Xaa en la posición 1 es S o T <400> 209 Xaa Xaa Asp Ile Asn 1 5 <210> 210 <211> 17 <212> PRT <213> Secuencia artificial <220> <223> Sintético <220> <221> VARIANTE <222> (7)..(7) <223> donde Xaa en la posición 7 es G o D <220> <221> VARIANTE <222> (8)..(8) <223> donde Xaa en la posición 8 es S o T o R <220> <221> VARIANTE <222> (9)..(9) <223> donde Xaa en la posición 9 es I o T <220> <221> VARIANTE <222> (13)..(13) <223> donde Xaa en la posición 13 es E o D <220> <221> VARIANTE <222> (14)..(14) <223> donde Xaa en la posición 14 es K o E <220> <221> VARIANTE <222> (16)..(16) <223> donde Xaa en la posición 16 es T o K <400> 210 Trp Ile Tyr Pro Arg Asp Xaa Xaa Xaa Lys Tyr Asn Xaa Xaa Phe Xaa 1 5 10 15 Asp <210> 211 <211> 5 <212> PRT <213> Secuencia artificial <220> <223> Sintético <220> <221> VARIANTE <222> (1)..(1) <223> donde Xaa en la posición 1 es L o V <220> <221> VARIANTE <222> (4)..(4) <223> donde Xaa en la posición 4 es T o S <400> 211 Xaa Glu Asp Xaa Tyr 1 5 <210> 212 <211> 17 <212> PRT <213> Secuencia artificial <220> <223> Sintético <220> <221> VARIANTEE <222> (8)..(8) <223> donde Xaa en la posición 8 es N o I o Q o A <220> <221> VARIANTE <222> (9)..(9) <223> donde Xaa en la posición 9 es S o T <220> <221> VARIANTE <222> (17)..(17) <223> donde Xaa en la posición 17 es A o S <400> 212 Lys Ser Ser Gln Ser Leu Leu Xaa Xaa Arg Thr Arg Lys Asn Tyr Leu 1 5 10 15 Xaa <210> 213 <211> 5 <212> PRT <213> Secuencia artificial <220> <223> Sintético <220> <221> VARIANTE <222> (4)..(4) <223> donde Xaa en la posición 4 es M o I <220> <221> VARIANTE <222> (5)..(5) <223> donde Xaa en la posición 5 es S o T <400> 213 Ser Tyr Gly Xaa Xaa 1 5 <210> 214 <211> 7 <212> PRT <213> Secuencia artificial <220> <223> Sintético <220> <221> VARIANTE <222> (3)..(3) <223> donde Xaa en la posición 3 es E o D <220> <221> VARIANTE <222> (5)..(5) <223> donde Xaa en la posición 5 es M o L <400> 214 Gly Gly Xaa Ala Xaa Asp Tyr 1 5 <210> 215 <211> 16 <212> PRT <213> Secuencia artificial <220> <223> Sintético <220> <221> VARIANTE <222> (10)..(10) <223> donde Xaa en la posición 10 es D o E o A <220> <221> VARIANTE <222> (11)..(11) <223> donde Xaa en la posición 11 es G o A <220> <221> VARIANTE <222> (16)..(16) <223> donde Xaa en la posición 16 es N o S <400> 215 Lys Ser Ser Gln Ser Leu Leu Asp Ser Xaa Xaa Lys Thr Tyr Leu Xaa 1 5 10 15 <210> 216 <211> 9 <212> PRT <213> Secuencia artificial <220> <223> Sintético <220> <221> VARIANTE <222> (8)..(8) <223> donde Xaa en la posición 8 es W o 216 Trp Gln Gly Thr His Phe Pro Xaa Thr 1 5 <210> 217 <211> 342 <212> ADN <213> Secuencia artificial <220> <223> Sintético <400> 217 caggtgcagc tgaagcagtc tggacctgag ctggtgaagc ctggggcttc agtgaagttg 60 tcctgcaagg cttctggcta caccttcaca accgacgata taaactgggt gaagcagagg 120 cctggacagg gacttgagtg gattggatgg atttatccta gagatgatag aactaagtac 180 aatgacaagt tcaaggacaa ggccacattg actgtagaca catcttccaa cacagcgtac 240 atggacctcc acagcctgac atctgaggac tctgcggtct atttctgttc aagcctcgag 300 gatacttact ggggccaagg gactctggtc gctgtctctt ca 342 <210> 218 <211> 342 <212> ADN <213> Secuencia artificial <220> <223> Sintético <400> 218 caggtgcagc tgaagcagtc tggacctgag ctggtgaagc ctggggcttc agtgaagttg 60 tcctgcaagg cttctggcta caccttcaca agtaacgata taaactgggt gaagcagagg 120 cctggacagg gacttgagtg gattggatgg atttatccta gagatgggag tattaaatat 180 aatgagaaat tcacggacaa ggccacattg acagttgacg tatcctccag cacagcgtac 240 atggagctcc acagcctgac atctgaggac tctgcggtct atttctgttc aggtgtcgag 300 gattcttact ggggccaagg gactctggtc actgtctctt ca 342 <210> 219 <211> 342 <212> ADN <213> Secuencia artificial <220> <223> Sintético <400> 219 caggtgcagc tgaagcagtc tggacctgaa ctggtgaagc ctggggcttc agtgaaattg 60 tcctgcaagg cttctggcta caccttcaca agtaacgata taaactgggt gaaacagagg 120 cctggacagg gacttgagtg gattggatgg atttatccta gagatggtac tactaagtac 180 aatgaggagt tcacggacaa ggccacattg actgttgacg tatcctccag cacagcgttc 240 atggagctcc acagcctgac atctgaggac tctgctgtct atttctgttc aagtgtcgag 300 gattcttact ggggccaagg gactctggtc actgtctctt ca 342 <210> 220 <211> 342 <212> ADN <213> Secuencia artificial <220> <223> Sintético <400> 220 caggtgcagc tgaagcagtc tggacctgag ctggtgaagc ctggggcttc agtgaagttg 60 tcctgcaagg cttctggcta caccttcaca agtaacgata taaactgggt gaagcagagg 120 cctggacagg gacttgagtg gattggatgg atttatccta gagatggtac tactaagtac 180 aatgagaagt tcacggacaa ggccacattg actgttgacg tatcctccag cacagcgttc 240 atggagctcc acaggctgac atctgaggac tctgcggtct atttctgttc aagtgtcgag 300 gattcttact ggggccaagg gactctggtc actgtctctt ca 342 <210> 221 <211> 348 <212> ADN <213> Secuencia artificial <220> <223> Sintético <400> 221 cagatccagt tggtacagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc 60 tcctgcaagg cttctgggta tattttcaca agctatggaa tgagctgggt gagacaggct 120 ccaggaaagg gtttaaagtg gatgggctgg ataaacacct actctggagt gccaacatat 180 gctgatgact tcaagggacg gtttgccttc tctttggaaa cctctgccag aactccctat 240 ttgcagatca acaacctcaa aaatgaggac acggctacat atttctgcgc aagagggggc 300 gaagctatgg actactgggg tcaaggaacc tcagtcaccg tctcctca 348 <210> 222 <211> 348 <212> ADN <213> Secuencia artificial <220> <223> Sintético <400> 222 cagatccagt tggtacagtc tggacctgag ctgaagacgc caggagagac agtcaagatc 60 tcctgcaagg cttctgggta tatcttcaca tcctatggaa ttacctgggt gaaacaggct 120 ccaggaaagg gtttaaagtg gatgggctgg ataaacacct actctggagt gccaacatat 180 gctgatgact tcaagggacg gtttgccttc tctttggaaa cgtctgccag cactgcctat 240 ttgcagatca acaacctcaa aaatgaggac acgactacat atttctgtac aagagggggt 300 gatgctttgg actactgggg tcaaggaacc tcagtcaccg tctcctca 348 <210> 223 <211> 339 <212> ADN <213> Secuencia artificial <220> <223> Sintético <400> 223 caggtgcagc tgaagcagtc tggagctgag ctgatgaagc ctggggcctc agtgaagctt 60 tcctgcaagg ctactggcta cacattcact ggcaagtgga tagagtgggt aaaacagagg 120 cctggacatg gcctagagtg gattggagag attttacctg gaactggtag tactaactac 180 aatgagaagt tcaagggcaa ggccacattc actgcagact catcctccaa cacagcctac 240 atgcaactca gcagcctgac aactgaagac tctgctatgt attattgttt aagatccgag 300 gatgtctggg gcacagggac cacggtcacc gtctcctca 339 <210> 224 <211> 339 <212> ADN <213> Secuencia artificial <220> <223> Sintético <400> 224 caggtgcagc tgaagcagtc tggagctgag ctgatgaagc ctggggcctc agtgaagctt 60 gcctgcaagg ctactggcta cacattcact ggctactgga tagagtggat aaagcagagg 120 cctggacaag gccttgagtg gattggagag atgttacctg gaagtggtag tactcactac 180 aatgagaagt tcaagggtaa ggccacattc actgcagata catcctccaa cacagcctac 240 atgcaactca gcggcctgac aactgaggac tctgccatct attactgtgt aagaagcata 300 gactactggg gccaaggcac cactctcaca gtctcctca 339 <210> 225 <211> 375 <212> ADN <213> Secuencia artificial <220> <223> Sintético <400> 225 caggtgcagc tgaagcagtc tgggcctgag ctggcaaggc cttgggcttc agtgaagata 60 tcctgccagg ctttctacac cttttccaga agggtgcact ttgccattag ggataccaac 120 tactggatgc agtgggtaaa acagaggcct ggacagggtc tggaatggat cggggctatt 180 tatcctggaa atggtgatac tagttacaat cagaagttca agggcaaggc cacattgact 240 gcagacaaat cctccagcac agcctacatg caactcagca gcctgacatc tgaggactct 300 gcggtctatt actgtgcatc cggtagccac tactttgact actggggcca aggcaccact 360 ctcacagtct cctca 375 <210> 226 <211> 369 <212> ADN <213> Secuencia artificial <220> <223> Sintético <400> 226 gaggtccagc tgcaacaatc tgggcctgag ctggtgaagc ctggggcttc agtgaaggta 60 tcctgtaagg cttctggata cacgctcact gactactaca tgaactgggt gaagcagagc 120 catggaaaga gccttgagtg gattggagat gttaatccta acaatgatgg tactacctac 180 aaccagaaat tcaagggcag ggccacattg actgtagaca agtcttccaa cacagcctcc 240 atggagctcc gcagcctgac atctgaggac tctgcagtct actactgtgc aatatgcccc 300 ttttattacc tcggtaaagg gacccacttt gactactggg gccaaggcac ctctctcaca 360 gtctcctca 369 <210> 227 <211> 372 <212> ADN <213> Secuencia artificial <220> <223> Sintético <400> 227 gaggtccagc tgcaacaatc tggacctgtg ctggtgaagc ctggggcttc agggaagatg 60 tcctgtaagg cttctggata caaattcact gactactata tgatctgggt gaagcagagc 120 catggaaaga gccttgagtg gattggagtt attaaaattt ataacggtgg tacgagctac 180 aaccagaagt tcaagggcaa ggccacattg actgttgaca agtcctccag cacagcctac 240 atggagctca acagcctgac atctgaggac tctgcagtct attactgtgc aagagggcca 300 tctctctatg attacgaccc ttactggtac ttcgatgtct ggggcacagg gaccacggtc 360 accgtctcct ca 372 <210> 228 <211> 360 <212> ADN <213> Secuencia artificial <220> <223> Sintético <400> 228 caggtgcagc tgaagcagtc tggaactgag ctgatgaagc ctggggcctc agtgaacctt 60 tcctgcaagg cttctggcta cacattcact gcctactgga tagagtgggt aaagcagagg 120 cctggacatg gccttgagtg gattggagag attttacctg gaagtggtac tactaactac 180 aatgagaact tcaaggacag ggccacattc actgcagata catcctccaa cacagcctac 240 atgcaactca gcagcctgac aagtgaggac tctgccatct attactgtgc aagatcctat 300 tactacgcta gtagatggtt tgctttctgg ggccaaggga ctctggtcac tgtctcttca 360 <210> 229 <211> 360 <212> ADN <213> Secuencia artificial <220> <223> Sintético <400> 229 gaggtccagc tgcagcagcc tggggctgag cttgtgaagc ctggggcttc agtgaagatg 60 tcctgtaagg cttctggcta caccttcacc agctactgga taacctgggt gaagcagagg 120 cctggacaag gccttgagtg gattggagat atttatcctg gtagtggtag tactaactac 180 aatgagaagt tcaagagcaa ggccacactg actgtagaca catcctccag cacagcctac 240 atgcagctca gcagcctgac atctgaggac tctgcggtct attactgtgc aagaaggaga 300 tactacgcta cggcctggtt tgcttactgg ggccaaggga ctctggtcac tgtctcttca 360 <210> 230 <211> 360 <212> ADN <213> Secuencia artificial <220> <223> Sintético <400> 230 caggtgcagc tgaagcagtc tggggctgag ctggtgaggc ctggggcttc agtgaagctg 60 tcctgcaagg cttctggcta cactttcact gactactata taaactgggt gaagcagagg 120 cctggacagg gacttgagtg gattgcaagg atttatcctg gaagtggtaa tacttactac 180 aatgagaagt tcaagggcaa ggccacactg actgcagaaa aatcctccag cactgcctac 240 atgcagctca gcagcctgac atctgaggac tctgctgtct atttctgtgc aagaaattac 300 tacattagta gtccctggtt tgcttactgg ggccaaggga ctctggtcac tgtctcttca 360 <210> 231 <211> 360 <212> ADN <213> Secuencia artificial <220> <223> Sintético <400> 231 caggtgcagc tgaagcagtc tggggctgag ctagtgacgc ctggagcctc agtgaagatg 60 tcctgcaagg cttctggcta caccttcact acctatccta tagagtggat gaaacagaat 120 catggaaaga gcctagagtg gattggaaat tttcatcctt acaatgatga tactaagtac 180 aatgaaaagt tcaagggcaa ggccacattg actgtagaaa aatcctctaa cacagtctac 240 ttggagctca gccgattaac atctgatgac tctgctgttt atttctgtgc aaggagggtc 300 tactatagtt acttctggtt tggttactgg ggccacggga ctctggtcac tgtctcttca 360 <210> 232 <211> 360 <212> ADN <213> Secuencia artificial <220> <223> Sintético <400> 232 caggtgcagc tgaagcagtc tggggctgag ctagtgaaac ctggagcctc agtgaagatg 60 tcctgcaagg cttctggcta caccttcact acctatccta tagagtggat gaagcagaat 120 catgggaaga gcctagagtg gattggaaat tttcatcctt acaatggtga ttctaagtac 180 aatgaaaagt tcaagggcaa ggccaccttg actgtagaaa aatcctctag cacagtctac 240 ttagaactca gccgattacc atctgctgac tctgctattt attactgtgc aaggaggcac 300 tacgctgcta gtccctggtt tgctcactgg ggccaaggga ctctggtcac tgtctcttca 360 <210> 233 <211> 339 <212> ADN <213> Secuencia artificial <220> <223> Sintético <400> 233 gacattgtga tgacccagtc tccatcctcc ctggctgtgt cagcaggaga gaaggtcact 60 atgacctgca aatccagtca gagtctgctc aacagtagaa cccgaaagaa ctacttggct 120 tggtaccagc agaaaccagg gcagtctcct aaactgctga tctactgggc atccactagg 180 gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt ctctctcacc 240 atcagcagtg tgcaggctga agacctggca gtttattact gcaagcaatc ttataatctg 300 tacacgttcg gaggggggac caagctggaa ataaaacgg 339 <210> 234 <211> 339 <212> ADN <213> Secuencia artificial <220> <223> Sintético <400> 234 gacattgtga tgacccagtc tccatcctcc ctggctgtgt cagcaggaga gagggtcact 60 atgagctgca aatccagtca gagtctgctc atcagtagaa cccgaaagaa ctatttgtct 120 tggtaccagc agaaaccagg gcagtctcct aaactgctga tctactgggc atccactagg 180 gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc 240 atcagcagtg tacaggctga agacctggca gtttattact gcaagcaatc ttataatctg 300 tacacgttcg gcggggggac caagctggaa ataaaacgg 339 <210> 235 <211> 339 <212> ADN <213> Secuencia artificial <220> <223> Sintético <400> 235 gacattgtga tgacccagtc tccatcctcc ctggctgtgt cagcaggaga gaaggtcact 60 atgagctgca aatccagtca gagtctgctc atcagtagaa cccgaaagaa ctatttgtct 120 tggtaccagc agaaaccagg gcagtctcct aaactgctga tctattgggc atccactagg 180 gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc 240 atcagcagtg tacaggctga agacctggca gtttattact gcaaacaatc ttataatctg 300 tacacgttcg gcggggggac caagctggaa atcaaacgg 339 <210> 236 <211> 339 <212> ADN <213> Secuencia artificial <220> <223> Sintético <400> 236 gatgttttga tgacccaaac tccactcact ttgtcggtta ccattggaca accagcctcc 60 atctcttgca agtcaagtca gagcctctta gatagtgatg gaaagacata tttgaattgg 120 ttgttacaga ggccaggcca gtctccaaag cgcctaatct atctggtgtc taaactggac 180 tctggagtcc ctgacaggtt cactggcagt ggatcaggga cagatttcac actgaaaatc 240 agcagagtgg aggctgagga tttgggagtt tattattgct ggcaaggtac acattttccg 300 tggacgttcg gtggaggcac caagctggaa atcaaacgg 339 <210> 237 <211> 339 <212> ADN <213> Secuencia artificial <220> <223> Sintético <400> 237 gatattgtga tgacgcaggc tccactcact ttgtcggtta ccattggaca accagcctcc 60 atctcttgca agtcaagtca gagcctctta gatagtgatg gaaagacata tttgagttgg 120 ttgttacaga ggccaggcca gtctccaaag cgcctaatct atctggtgtc taaactggac 180 tctggagtcc ctgacaggtt cactggcagt ggatcaggga cagatttcac actgaaaatc 240 agcagagtgg aggctgagga tttgggagtt tattattgct ggcaaggtac acattttccg 300 tacacgttcg gaggggggac caagctggaa ataaaacgg 339 <210> 238 <211> 339 <212> ADN <213> Secuencia artificial <220> <223> Sintético <400> 238 gacattgtga tgacccagtc tccatcctcc ctggctgtgt cagcaggaga gaaggtcact 60 atgagctgca aatccagtca gagtctgctc aacagtagaa cccgaaagaa ctacttggct 120 tggtaccagc agaaaccagg gcagtctcct aaactgctga tctactgggc atccactagg 180 gaatctgggg tccctgatcg cttcacaggc agtggatctg gaacagattt cactctcacc 240 atcagcagtg tgcaggctga agacctggca gtttattact gcaagcaatc ttataatatt 300 ccgacgttcg gtggaggcac caagctggaa atcaaacgg 339 <210> 239 <211> 339 <212> ADN <213> Secuencia artificial <220> <223> Sintético <400> 239 gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga acaagcctcc 60 atctcttgca gatcaagtca gagccttgta caaagtaatg gaaacaccta tttacattgg 120 tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt 180 tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc 240 agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttcct 300 ccgacgttcg gtggaggcac caagctggaa atcaaacgg 339 <210> 240 <211> 324 <212> ADN <213> Secuencia artificial <220> <223> Sintético <400> 240 gacatccagc tgactcagtc tccagccatc ctgtctgtga gtccaggaga aagagtcagt 60 ttctcctgca gggccagtca gagcattggc acaagcatac actggtatca gcaaagaaca 120 aatggttctc caaggcttct cataaagtat gcttctgagt ctatctctgg gatcccttcc 180 aggtttagtg gcagtggatc agggacagat tttactctta gcatcaacag tgtggagtct 240 gaagatattg cagattatta ctgtcaacaa agtaatagct ggccgtacac gttcggaggg 300 gggaccaagc tggaaataaa acgg 324 <210> 241 <211> 324 <212> ADN <213> Secuencia artificial <220> <223> Sintético <400> 241 gatatccaga tgacacagac tccagcctcc ctgtctgcct ctctgggaga cagagtcacc 60 atcagttgta gggcaagtca ggacattagc aattttttaa actggtatca acagaaaccg 120 aatggaactg ttaaactcct agtcttctac acatcaagat tacactcagg agtcccatca 180 aggttcagtg gcagtgggtc tggagcagag cattctctca ccattagcaa cctggagcag 240 gaagatgttg ccacttactt ttgccaacag ggttttacgc ttccgtggac gttcggtggg 300 ggcaccaagg tggaaatcaa acgg 324 <210> 242 <211> 339 <212> ADN <213> Secuencia artificial <220> <223> Sintético <400> 242 gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc 60 ttctcttgca gatctagtca gagccttata cacagtaatg gaaacaccta tttacattgg 120 tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt 180 tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc 240 agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttccg 300 tggacgttcg gtggaggcac caagctggaa atcaaacgg 339 <210> 243 <211> 324 <212> ADN <213> Secuencia artificial <220> <223> Sintético <400> 243 gacattgtga tgacccagtc tcaaaaattc atgtccacat caataggaga cagggtcagc 60 gtcacctgca gggccagtca gaatgtgggt cccaatttag cctggtatca acagaaacca 120 gggcaatctc ctaaagcact gatttactcg gcatcctacc gattcagtgg agtccctgat 180 cgcttcacag gcagtggatc tgggacagat ttcactctca ccatcagcaa tgtgcagtct 240 gaagacttgg cagagtattt ctgtcagcaa tataacaggt atccattcac gttcggctcg 300 gggacaaagt tggaaataaa acgg 324 <210> 244 <211> 324 <212> ADN <213> Secuencia artificial <220> <223> Sintético <400> 244 gacattgtga tgacccagtc tcaaaaattc atgtccacat cagtaggaga cagggtcagc 60 atcacctgca aggccagtca gaatgtgggt actgctgtag cctggtatca acagaaacca 120 ggacaatctc ctaaactact gatttcctcg gcatccaatc ggtacactgg agtccctgat 180 cgcttcacag gcagtggatc tgggacagat ttcactctca ccatcagtaa tatgcagtct 240 gaagacgtgg cagattattt ctgccagcaa tataacagct atcctctcac gttcggtgct 300 gggaccaagc tggagctgaa acgg 324 <210> 245 <211> 324 <212> ADN <213> Secuencia artificial <220> <223> Sintético <400> 245 gacattgtga tgacccagtc tcaaaaattc atgtccactt cagtaggaga cagggtcagc 60 gtcacctgca aggccagtca gaatgtgggt cctaatgtag cctggtatca acagaaacca 120 gggcaatctc ctaaagcact gatttactcg gcatcctacc ggtacagtgg agtccctgat 180 cgcttcacag gcagtggatc tgggacagat ttcactctca ccatcagcaa tgtgcagtct 240 gaagacttgg cagactattt ctgtcagcaa tataaccgct atcctctcac gttcggtgct 300 gggaccaaac tggagctgaa acgg 324 <210> 246 <211> 330 <212> ADN <213> Secuencia artificial <220> <223> Sintético <400> 246 gacattgtga tgacccagtc tcaaaaattc atgtccacat cagtaggaga cagggtcaac 60 gtcacctgca aggccagtca gaatgtgggt actcatgtag cctggtatca acagaaacca 120 gggcaatctc ctaaagcact gatttactcg gcatcctacc ggtacagtgg cgtccctgat 180 cgcttcacag gcagtggatc tgggacagat ttcactctca ccatcagcaa tgtgcagtct 240 gaagacctgg cagagtattt ctgtcagcaa tataacagct atcctcgagc gctcacgttc 300 ggtgctggga ccaagctgga gctgaaacgg 330 <210> 247 <211> 324 <212> ADN <213> Secuencia artificial <220> <223> Sintético <400> 247 gacattgtga tgacccagtc tcaaaaattc atgtccacat cagtaggaga cagggtcaac 60 gtcacctgca aggccagtca gaatgtgggt cctactgtag cctggtatca acagaaacca 120 gggcaatctc ctaaagcact aatttactcg gcatcctacc ggtacagtgg agtccctgat 180 cgcttcacag gcagtggatc tgggacagat ttcactctca ccatcagcaa tgtgcactct 240 gaagacttgg cagagtattt ctgtcagcaa tataacagct atccattcac gttcggctcg 300 gggacaaagt tggaaataaa acgg 324 <210> 248 <211> 114 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 248 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Asp 20 25 30 Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Trp Ile Tyr Pro Arg Asp Asp Arg Thr Lys Tyr Asn Asp Lys Phe 50 55 60 Lys Asp Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ser Ser Leu Glu Asp Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 100 105 110 Ser Ser <210> 249 <211> 114 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 249 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Asp 20 25 30 Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Trp Ile Tyr Pro Arg Asp Asp Arg Thr Lys Tyr Asn Asp Lys Phe 50 55 60 Lys Asp Arg Ala Thr Leu Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ser Ser Leu Glu Asp Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 100 105 110 Ser Ser <210> 250 <211> 113 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 250 Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 20 25 30 Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 35 40 45 Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 50 55 60 Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 65 70 75 80 Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 85 90 95 Ser Tyr Asn Leu Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 110 Arg <210> 251 <211> 116 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 251 Gln Ile Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 20 25 30 Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 35 40 45 Gly Trp Ile Asn Thr Tyr Ser Gly Val Pro Thr Tyr Ala Asp Asp Phe 50 55 60 Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Arg Thr Pro Tyr 65 70 75 80 Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Arg Gly Gly Glu Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 252 <211> 116 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 252 Gln Ile Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 20 25 30 Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 35 40 45 Gly Trp Ile Asn Thr Tyr Ser Gly Val Pro Thr Tyr Ala Asp Asp Phe 50 55 60 Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Arg Thr Pro Tyr 65 70 75 80 Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Thr Tyr Phe Cys 85 90 95 Ala Arg Gly Gly Glu Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 253 <211> 113 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 253 Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 1 5 10 15 Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 20 25 30 Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 35 40 45 Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Trp Gln Gly 85 90 95 Thr His Phe Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 110 Arg <210> 254 <211> 113 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 254 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Lys 20 25 30 Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Leu Pro Gly Thr Gly Ser Thr Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Ala Thr Phe Thr Ala Asp Ser Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Leu Arg Ser Glu Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser 100 105 110 Ser <210> 255 <211> 113 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 255 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Lys 20 25 30 Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Leu Pro Gly Thr Gly Ser Thr Asn Tyr Asn Glu Lys Phe 50 55 60 Lys Gly Arg Ala Thr Phe Thr Ala Asp Ser Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Leu Arg Ser Glu Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser 100 105 110 Ser <210> 256 <211> 113 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 256 Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 20 25 30 Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 35 40 45 Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 50 55 60 Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 65 70 75 80 Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 85 90 95 Ser Tyr Asn Ile Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 110 Arg <210> 257 <211> 17 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 257 Lys Ser Ser Gln Ser Leu Leu Gln Ser Arg Thr Arg Lys Asn Tyr Leu 1 5 10 15 Ala <210> 258 <211> 17 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 258 Lys Ser Ser Gln Ser Leu Leu Ala Ser Arg Thr Arg Lys Asn Tyr Leu 1 5 10 15 Ala <210> 259 <211> 17 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 259 Lys Ser Ser Gln Ser Leu Leu Asn Thr Arg Thr Arg Lys Asn Tyr Leu 1 5 10 15 Ala <210> 260 <211> 17 <212> PRT <213> Secuencia artificial <220> <223> Sintético <220> <221> VARIANTE <222> (8)..(8) <223> donde Xaa en la posición 8 es N o Q o A <220> <221> VARIANTE <222> (9)..(9) <223> donde Xaa en la posición 9 es S o T <400> 260 Lys Ser Ser Gln Ser Leu Leu Xaa Xaa Arg Thr Arg Lys Asn Tyr Leu 1 5 10 15 Ala <210> 261 <211> 16 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 261 Lys Ser Ser Gln Ser Leu Leu Asp Ser Glu Gly Lys Thr Tyr Leu Asn 1 5 10 15 <210> 262 <211> 16 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 262 Lys Ser Ser Gln Ser Leu Leu Asp Ser Ala Gly Lys Thr Tyr Leu Asn 1 5 10 15 <210> 263 <211> 16 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 263 Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Ala Lys Thr Tyr Leu Asn 1 5 10 15 <210> 264 <211> 30 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 264 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 20 25 30 <210> 265 <211> 14 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 265 Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly 1 5 10 <210> 266 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 266 Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr Met Glu 1 5 10 15 Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ser Ser 20 25 30 <210> 267 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 267 Arg Ala Thr Leu Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr Met Glu 1 5 10 15 Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ser Ser 20 25 30 <210> 268 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 268 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 1 5 10 <210> 269 <211> 30 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 269 Gln Ile Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr 20 25 30 <210> 270 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 270 Arg Phe Val Phe Ser Leu Asp Thr Ser Val Arg Thr Pro Tyr Leu Gln 1 5 10 15 Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg 20 25 30 <210> 271 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 271 Arg Phe Val Phe Ser Leu Asp Thr Ser Val Arg Thr Pro Tyr Leu Gln 1 5 10 15 Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 20 25 30 <210> 272 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 272 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 1 5 10 <210> 273 <211> 30 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 273 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 20 25 30 <210> 274 <211> 14 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 274 Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly 1 5 10 <210> 275 <211> 17 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 275 Glu Ile Leu Pro Gly Thr Gly Ser Thr Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 276 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 276 Arg Ala Thr Phe Thr Ala Asp Ser Ser Thr Ser Thr Ala Tyr Met Glu 1 5 10 15 Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Leu Arg 20 25 30 <210> 277 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 277 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 1 5 10 <210> 278 <211> 113 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 278 Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Ala Ser 20 25 30 Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 35 40 45 Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 50 55 60 Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 65 70 75 80 Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 85 90 95 Ser Tyr Asn Leu Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 110 Arg <210> 279 <211> 113 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 279 Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 1 5 10 15 Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 20 25 30 Asp Ala Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 35 40 45 Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Trp Gln Gly 85 90 95 Thr His Phe Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 110 Arg <210> 280 <211> 113 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 280 Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Ala Ser 20 25 30 Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 35 40 45 Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 50 55 60 Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 65 70 75 80 Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 85 90 95 Ser Tyr Asn Ile Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 110 Arg <210> 281 <211> 23 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 281 Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Glu Arg Ala Thr Ile Asn Cys 20 <210> 282 <211> 15 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 282 Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 1 5 10 15 <210> 283 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 283 Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 1 5 10 15 Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys 20 25 30 <210> 284 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 284 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 1 5 10 <210> 285 <211> 23 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 285 Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 1 5 10 15 Gln Pro Ala Ser Ile Ser Cys 20 <210> 286 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 286 Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 1 5 10 15 Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 20 25 30 <210> 287 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 287 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 1 5 10 <210> 288 <211> 342 <212> ADN <213> Secuencia artificial <220> <223> Sintético <400> 288 caagtccaac tcgtccagtc cggggccgaa gtcaagaagc cgggagcctc agtgaaagtg 60 tcgtgcaaag cttccggcta caccttcacc accgatgaca ttaactgggt cagacaggcg 120 cccggacagg ggctggaatg gatcggttgg atctaccctc gggacgaccg gactaagtac 180 aacgacaagt tcaaggacaa agcgaccctc accgtcgaca ccagcagcaa cactgcctac 240 atggaactgt catccctgag gagcgaggac actgccgtgt attactgttc gagcctggag 300 gatacctact ggggacaggg cactcttgtg accgtgtcct cc 342 <210> 289 <211> 342 <212> ADN <213> Secuencia artificial <220> <223> Sintético <400> 289 caagtccaac tcgtccagtc cggggccgaa gtcaagaagc cgggagcctc agtgaaagtg 60 tcgtgcaaag cttccggcta caccttcacc accgatgaca ttaactgggt cagacaggcg 120 cccggacagg ggctggaatg gatcggttgg atctaccctc gggacgaccg gactaagtac 180 aacgacaagt tcaaggacag agcgaccctc accgtcgaca ccagcagcaa cactgcctac 240 atggaactgt catccctgag gagcgaggac actgccgtgt attactgttc gagcctggag 300 gatacctact ggggacaggg cactcttgtg accgtgtcct cc 342 <210> 290 <211> 348 <212> ADN <213> Secuencia artificial <220> <223> Sintético <400> 290 caaatccagc tggtccagtc cggttccgag ctcaagaagc cgggagcctc agtgaaagtg 60 tcgtgcaagg cctccggtta catcttcacc tcctacggaa tgtcgtgggt ccgccaagca 120 cctggaaagg gccttaagtg gatggggtgg atcaacacct atagcggcgt gcccacttac 180 gccgacgact ttaagggccg gttcgtgttc tccctggata cgtccgtgcg cactccgtac 240 ctccaaatta gcagcctgaa ggccgaagat actgcggtgt acttctgcgc tagaggaggg 300 gaagccatgg actactgggg acagggcacc ctggtcaccg tgtcgtcc 348 <210> 291 <211> 348 <212> ADN <213> Secuencia artificial <220> <223> Sintético <400> 291 caaatccagc tggtccagtc cggttccgag ctcaagaagc cgggagcctc agtgaaagtg 60 tcgtgcaagg cctccggtta catcttcacc tcctacggaa tgtcgtgggt ccgccaagca 120 cctggaaagg gccttaagtg gatggggtgg atcaacacct atagcggcgt gcccacttac 180 gccgacgact ttaagggccg gttcgtgttc tccctggata cgtccgtgcg cactccgtac 240 ctccaaatta gcagcctgaa ggccgaagat actgcgacgt acttctgcgc tagaggaggg 300 gaagccatgg actactgggg acagggcacc ctggtcaccg tgtcgtcc 348 <210> 292 <211> 339 <212> ADN <213> Secuencia artificial <220> <223> Sintético <400> 292 caagtccaac tcgtgcagtc aggagcagaa gtcaagaagc cgggagcctc cgtgaaagtg 60 tcgtgcaagg cctccggata cactttcacc gggaagtgga ttgaatgggt ccgccaggcg 120 cccggccagg gcctggagtg gatcggagag atcctgcctg gtaccggtag cactaactac 180 gctcagaagt tccagggcag agcgaccttc accgccgact cgagcacctc cactgcgtac 240 atggaactga gctccctgag gtcggaggac accgccgtgt attactgcct ccggtccgaa 300 gatgtctggg gccaggggac cctcgtgact gtgtcatcc 339 <210> 293 <211> 339 <212> ADN <213> Secuencia artificial <220> <223> Sintético <400> 293 caagtccaac tcgtgcagtc aggagcagaa gtcaagaagc cgggagcctc cgtgaaagtg 60 tcgtgcaagg cctccggata cactttcacc gggaagtgga ttgaatgggt ccgccaggcg 120 cccggccagg gcctggagtg gatcggagag atcctgcctg gtaccggtag cactaactac 180 aacgagaagt tcaagggcag agcgaccttc accgccgact cgagcacctc cactgcgtac 240 atggaactga gctccctgag gtcggaggac accgccgtgt attactgcct ccggtccgaa 300 gatgtctggg gccaggggac cctcgtgact gtgtcatcc 339 <210> 294 <211> 339 <212> ADN <213> Secuencia artificial <220> <223> Sintético <400> 294 gatattgtca tgacccagtc ccccgattcc cttgctgtct ccctgggcga acgcgcgact 60 attaactgca agagctcaca gtcgctgctg aattcccgga ctcggaagaa ctacctggcc 120 tggtaccagc agaagcctgg gcaaccgccg aagctcttga tctactgggc ctcgactaga 180 gagagcggag tgccagaccg cttctccggt tccggatcag gaaccgactt taccctgacc 240 atctcgagcc tgcaagcaga ggacgtggcc gtgtattact gcaagcagtc ctacaacctc 300 tacacgttcg gccagggcac caaagtggaa atcaagagg 339 <210> 295 <211> 339 <212> ADN <213> Secuencia artificial <220> <223> Sintético <400> 295 gatatcgtca tgacccaatc ccccgattcc cttgctgtct cactgggaga aagagccacc 60 atcaactgca agagctcgca gtccctgctg gctagcagga ctcgcaagaa ctacctggcc 120 tggtatcagc agaagcccgg acagcctcca aagctcttga tctactgggc ctccactcgg 180 gagtccggcg tgccggaccg gttcagcgga tcaggctccg gtactgactt caccctcacc 240 atttcgtcgc tgcaagcaga ggacgtggcg gtgtactact gcaagcagtc ctacaacatt 300 ccgacgtttg ggcagggcac caaagtggaa atcaagcgc 339 <210> 296 <211> 339 <212> ADN <213> Secuencia artificial <220> <223> Sintético <400> 296 gacgtgctga tgacccaaac ccccctttcc ctgtccgtga ctcctggaca acccgcgtca 60 atctcctgca agagctcgca gtccctcctc gactccgacg gaaaaaccta cctgaactgg 120 cttttgcaga ggccagggca gagcccgaag cggctgatct acctcgtgtc caagctggac 180 tccggagtgc cggatcgctt ctcgggatca ggctcgggta ccgatttcac gctgaagatc 240 tccagagtgg aagccgagga cgtgggcgtc tactactgtt ggcagggcac tcactttccg 300 tggaccttcg gtcaagggac caaggtcgag attaagagg 339 <210> 297 <211> 339 <212> ADN <213> Secuencia artificial <220> <223> Sintético <400> 297 gacgtgctga tgacccaaac ccccctttcc ctgtccgtga ctcctggaca acccgcgtca 60 atctcctgca agagctcgca gtccctcctc gactccgacg caaaaaccta cctgaactgg 120 cttttgcaga ggccagggca gagcccgaag cggctgatct acctcgtgtc caagctggac 180 tccggagtgc cggatcgctt ctcgggatca ggctcgggta ccgatttcac gctgaagatc 240 tccagagtgg aagccgagga cgtgggcgtc tactactgtt ggcagggcac tcactttccg 300 tggaccttcg gtcaagggac caaggtcgag attaagagg 339 <210> 298 <211> 339 <212> ADN <213> Secuencia artificial <220> <223> Sintético <400> 298 gatatcgtca tgacccaatc ccccgattcc cttgctgtct cactgggaga aagagccacc 60 atcaactgca agagctcgca gtccctgctg aatagcagga ctcgcaagaa ctacctggcc 120 tggtatcagc agaagcccgg acagcctcca aagctcttga tctactgggc ctccactcgg 180 gagtccggcg tgccggaccg gttcagcgga tcaggctccg gtactgactt caccctcacc 240 atttcgtcgc tgcaagcaga ggacgtggcg gtgtactact gcaagcagtc ctacaacatt 300 ccgacgtttg ggcagggcac caaagtggaa atcaagcgc 339 <210> 299 <211> 339 <212> ADN <213> Secuencia artificial <220> <223> Sintético <400> 299 gatattgtca tgacccagtc ccccgattcc cttgctgtct ccctgggcga acgcgcgact 60 attaactgca agagctcaca gtcgctgctg gcttcccgga ctcggaagaa ctacctggcc 120 tggtaccagc agaagcctgg gcaaccgccg aagctcttga tctactgggc ctcgactaga 180 gagagcggag tgccagaccg cttctccggt tccggatcag gaaccgactt taccctgacc 240 atctcgagcc tgcaagcaga ggacgtggcc gtgtattact gcaagcagtc ctacaacctc 300 tacacgttcg gccagggcac caaagtggaa atcaagagg 339 <210> 300 <211> 125 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 300 Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 1 5 10 15 Ala Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Asn 20 25 30 Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Gly Ile Asp Asp Asp Gly Ser Gly Thr Arg Tyr Ala Pro Ala Val 50 55 60 Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Leu Arg 65 70 75 80 Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys 85 90 95 Thr Lys Cys Ala Tyr Ser Ser Gly Cys Asp Tyr Glu Gly Gly Tyr Ile 100 105 110 Asp Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 115 120 125 <210> 301 <211> 118 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 301 Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 1 5 10 15 Gly Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Gly Trp Met Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 35 40 45 Ala Gly Ile Arg Ser Asp Gly Ser Phe Thr Leu Tyr Ala Thr Ala Val 50 55 60 Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Val Arg 65 70 75 80 Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys 85 90 95 Thr Arg Ser Gly Asn Val Gly Asp Ile Asp Ala Trp Gly His Gly Thr 100 105 110 Glu Val Ile Val Ser Ser 115 <210> 302 <211> 128 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 302 Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 1 5 10 15 Gly Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Asp Phe Ser Ser Tyr 20 25 30 Gln Met Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 35 40 45 Ala Ala Ile Asn Arg Phe Gly Asn Ser Thr Gly His Gly Ala Ala Val 50 55 60 Lys Gly Arg Val Thr Ile Ser Arg Asp Asp Gly Gln Ser Thr Val Arg 65 70 75 80 Leu Gln Leu Ser Asn Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys 85 90 95 Ala Lys Gly Val Tyr Gly Tyr Cys Gly Ser Tyr Ser Cys Cys Gly Val 100 105 110 Asp Thr Ile Asp Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 115 120 125 <210> 303 <211> 107 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 303 Ala Leu Thr Gln Pro Ala Ser Val Ser Ala Asn Leu Gly Gly Thr Val 1 5 10 15 Lys Ile Thr Cys Ser Gly Gly Gly Ser Tyr Ala Gly Ser Tyr Tyr Tyr 20 25 30 Gly Trp Tyr Gln Gln Lys Ser Pro Gly Ser Ala Pro Val Thr Val Ile 35 40 45 Tyr Asp Asn Asp Lys Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly 50 55 60 Ser Leu Ser Gly Ser Thr Asn Thr Leu Thr Ile Thr Gly Val Arg Ala 65 70 75 80 Asp Asp Glu Ala Val Tyr Phe Cys Gly Ser Ala Asp Asn Ser Gly Ala 85 90 95 Ala Phe Gly Ala Gly Thr Thr Leu Thr Val Leu 100 105 <210> 304 <211> 108 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 304 Ala Leu Thr Gln Pro Ala Ser Val Ser Ala Asn Pro Gly Glu Thr Val 1 5 10 15 Lys Ile Thr Cys Ser Gly Gly Tyr Ser Gly Tyr Ala Gly Ser Tyr Tyr 20 25 30 Tyr Gly Trp Tyr Gln Gln Lys Ala Pro Gly Ser Ala Pro Val Thr Leu 35 40 45 Ile Tyr Tyr Asn Asn Lys Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser 50 55 60 Gly Ser Leu Ser Gly Ser Thr Asn Thr Leu Thr Ile Thr Gly Val Arg 65 70 75 80 Ala Asp Asp Glu Ala Val Tyr Phe Cys Gly Ser Ala Asp Asn Ser Gly 85 90 95 Ala Ala Phe Gly Ala Gly Thr Thr Leu Thr Val Leu 100 105 <210> 305 <211> 107 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 305 Ala Leu Thr Gln Pro Ala Ser Val Ser Ala Asn Pro Gly Glu Thr Val 1 5 10 15 Lys Ile Thr Cys Ser Gly Gly Gly Ser Tyr Ala Gly Ser Tyr Tyr Tyr 20 25 30 Gly Trp Tyr Gln Gln Lys Ala Pro Gly Ser Ala Pro Val Thr Leu Ile 35 40 45 Tyr Tyr Asn Asn Lys Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly 50 55 60 Ser Leu Ser Gly Ser Thr Asn Thr Leu Thr Ile Thr Gly Val Arg Ala 65 70 75 80 Asp Asp Glu Ala Val Tyr Phe Cys Gly Ser Ala Asp Asn Ser Gly Ala 85 90 95 Ala Phe Gly Ala Gly Thr Thr Leu Thr Val Leu 100 105 <210> 306 <211> 126 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 306 Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 1 5 10 15 Ala Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Gly Ile Tyr Lys Ser Gly Ala Gly Thr Asn Tyr Ala Pro Ala Val 50 55 60 Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Val Arg 65 70 75 80 Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys 85 90 95 Ala Lys Thr Thr Gly Ser Gly Cys Ser Ser Gly Tyr Arg Ala Glu Tyr 100 105 110 Ile Asp Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 115 120 125 <210> 307 <211> 107 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 307 Ala Leu Thr Gln Pro Ala Ser Val Ser Ala Asn Pro Gly Glu Thr Val 1 5 10 15 Lys Ile Thr Cys Ser Gly Gly Gly Ser Tyr Ala Gly Ser Tyr Tyr Tyr 20 25 30 Gly Trp Tyr Gln Gln Lys Ala Pro Gly Ser Ala Pro Val Thr Leu Ile 35 40 45 Tyr Tyr Asn Asn Lys Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly 50 55 60 Ser Leu Ser Gly Ser Thr Asn Thr Leu Thr Ile Thr Gly Val Arg Ala 65 70 75 80 Asp Asp Glu Ala Val Tyr Phe Cys Gly Ser Ala Asp Asn Ser Gly Ala 85 90 95 Ala Phe Gly Ala Gly Thr Thr Leu Thr Val Leu 100 105 <210> 308 <211> 126 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 308 Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 1 5 10 15 Ala Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Asp Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 35 40 45 Ala Gly Ile Ser Arg Asn Asp Gly Arg Tyr Thr Glu Tyr Gly Ser Ala 50 55 60 Val Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Val 65 70 75 80 Arg Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Asp Ala Gly Gly Ser Ala Tyr Trp Phe Asp Ala Gly Gln 100 105 110 Ile Asp Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 115 120 125 <210> 309 <211> 107 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 309 Ala Leu Thr Gln Pro Ala Ser Val Ser Ala Asn Pro Gly Glu Thr Val 1 5 10 15 Lys Ile Thr Cys Ser Gly Gly Gly Ser Tyr Ala Gly Ser Tyr Tyr Tyr 20 25 30 Gly Trp Tyr Gln Gln Lys Ala Pro Gly Ser Ala Pro Val Thr Leu Ile 35 40 45 Tyr Tyr Asn Asn Lys Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly 50 55 60 Ser Leu Ser Gly Ser Thr Asn Thr Leu Thr Ile Thr Gly Val Arg Ala 65 70 75 80 Asp Asp Glu Ala Val Tyr Phe Cys Gly Ser Ala Asp Asn Ser Gly Ala 85 90 95 Ala Phe Gly Ala Gly Thr Thr Leu Thr Val Leu 100 105 <210> 310 <211> 327 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 310 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 1 5 10 15 Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 65 70 75 80 Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 100 105 110 Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 115 120 125 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 130 135 140 Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 145 150 155 160 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 165 170 175 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 180 185 190 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 195 200 205 Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 210 215 220 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 225 230 235 240 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 245 250 255 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 260 265 270 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 275 280 285 Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 290 295 300 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 305 310 315 320 Leu Ser Leu Ser Leu Gly Lys 325 <210> 311 <211> 327 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 311 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 1 5 10 15 Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 65 70 75 80 Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 100 105 110 Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 115 120 125 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 130 135 140 Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 145 150 155 160 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 165 170 175 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 180 185 190 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 195 200 205 Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 210 215 220 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 225 230 235 240 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 245 250 255 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 260 265 270 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 275 280 285 Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 290 295 300 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 305 310 315 320 Leu Ser Leu Ser Leu Gly Lys 325 <210> 312 <211> 327 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 312 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 1 5 10 15 Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 65 70 75 80 Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 100 105 110 Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 115 120 125 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 130 135 140 Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 145 150 155 160 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 165 170 175 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 180 185 190 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 195 200 205 Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 210 215 220 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 225 230 235 240 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 245 250 255 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 260 265 270 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 275 280 285 Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 290 295 300 Cys Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr Gln Lys Ser 305 310 315 320 Leu Ser Leu Ser Leu Gly Lys 325 <210> 313 <211> 106 <212> PRT <213> Secuencia artificial <220> <223> Sintético <400> 313 Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 1 5 10 15 Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 20 25 30 Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 35 40 45 Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 50 55 60 Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 65 70 75 80 His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 85 90 95 Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 100 105