LISTA DE SECUENCIAS <110> BIOVERATIV THERAPEUTICS INC. <120> MOLÉCULAS DE ÁCIDO NUCLEICO Y USOS DE LAS MISMAS PARA TERAPIA GÉNICA NO VIRAL <130> 615113: SA9-465PC <150> 62/716.826 <151> 09-08-2018 <160> 198 <170> PatentIn versión 3.5 <210> 1 <211> 4374 <212> ADN <213> Secuencia Artificial <220> <223> coFVIII-5 <400> 1 atgcaaatcg aactgagcac ctgtttcttc ctctgcctgc tgagattctg tttctccgcg 60 acccgccgat actacctggg agcagtggag ctctcctggg attacatgca gagcgacctt 120 ggggagctgc ccgtggatgc caggttccct ccccgggtgc caaagtcgtt tccgttcaac 180 acctccgtgg tgtacaagaa aactctgttc gtggagttca ccgaccacct gttcaatatc 240 gccaagccca gacctccctg gatggggctg ttgggaccta ccatccaagc ggaggtgtac 300 gacactgtgg tcatcactct gaagaacatg gcctcgcatc ccgtgtccct gcacgccgtg 360 ggagtgtctt actggaaagc gtccgagggg gccgaatacg acgaccagac ctcgcagaga 420 gaaaaggaag atgacaaggt gttcccagga ggatcgcaca cctacgtgtg gcaagtgttg 480 aaggagaacg gcccaatggc ctccgacccg ctgtgcctga cctactcgta cctgtcccac 540 gtggacctcg tgaaggacct caactcggga ctgattggag ccctgctggt ctgcagggaa 600 ggctcactgg cgaaagaaaa gactcagacc ttgcacaagt tcattctgct gttcgctgtg 660 ttcgacgagg ggaagtcgtg gcacagcgag actaagaact ccctgatgca agatagagat 720 gccgcctccg cccgggcctg gcctaagatg cacaccgtga acggttacgt gaaccgctcc 780 ctccctggcc tgattggatg ccaccggaag tccgtgtact ggcacgtgat cgggatgggg 840 accacccccg aggtgcacag catcttcctg gaaggtcaca catttctcgt gcgcaaccac 900 cggcaggcct ccctggaaat cagccccatt accttcctca ctgcccagac tctgctgatg 960 gacctgggac agttcctgct gttctgccat atctcctccc accaacatga cggaatggag 1020 gcatacgtga aggtcgattc ctgccctgag gaaccccagc tccgcatgaa gaacaatgag 1080 gaagccgagg actacgacga cgacctgacg gatagcgaga tggatgtggt ccggttcgat 1140 gacgataaca gcccttcctt catccaaatt cgctcggtgg caaagaagca ccccaagacc 1200 tgggtgcatt acattgcggc ggaagaagag gactgggatt atgccccgct tgtcctcgct 1260 cctgacgacc ggagctacaa gagccagtac ctgaacaacg gtccacagag gatcggtaga 1320 aagtacaaga aggtccgctt catggcctat accgacgaaa ccttcaaaac tagagaggcc 1380 atccaacacg aatccggcat cctgggcccg ctcttgtacg gagaagtcgg cgacaccctt 1440 ctcattatct tcaagaacca ggcttcccgg ccgtacaaca tctatccgca tgggatcact 1500 gacgtgcgcc cactgtactc gcggcgcctg cccaagggtg tcaaacacct gaaggatttt 1560 ccgatccttc cgggagaaat cttcaagtac aagtggaccg tgaccgtgga agatggccca 1620 actaagtctg accctagatg cctcacccgc tactactcat ccttcgtcaa catggagcgc 1680 gacctggcca gcggactgat cggcccgctg ctgatttgct acaaggaatc agtggaccaa 1740 cggggaaacc agatcatgtc ggataagagg aacgtcatcc tcttctccgt gtttgacgaa 1800 aaccggtcgt ggtacctgac tgaaaacatc cagcggttcc tccccaaccc cgcgggcgtg 1860 cagctggaag atcctgagtt tcaggcatca aacatcatgc actccattaa cggctacgtg 1920 ttcgattcgc tgcagctgag cgtgtgtctg cacgaagtgg cctactggta catcctgtcc 1980 attggtgccc agactgactt cctgtccgtg tttttctccg gctacacgtt caagcacaag 2040 atggtgtacg aggacaccct gaccctcttc cctttttccg gcgaaactgt gtttatgagc 2100 atggagaatc ccggcctgtg gatcttgggc tgccacaaca gcgacttccg taacagagga 2160 atgactgcgc tgctcaaggt gtccagctgc gacaagaaca ccggagacta ttatgaggac 2220 tcatacgagg acatctccgc ctacctcctg tccaagaata acgccattga acctcggagc 2280 ttcagccaga acccacccgt gcttaagaga catcaacggg agatcactag gaccaccctg 2340 cagtcagacc aggaggaaat cgactacgat gacaccatct cggtcgagat gaagaaggag 2400 gactttgaca tctacgacga agatgaaaac cagagcccga ggtcgttcca aaagaaaacc 2460 cgccactact ttattgctgc tgtcgagcgg ctgtgggact acggaatgtc gtcctcgccg 2520 cacgtgctcc gcaaccgagc ccagagcggc tcggtgccgc aattcaagaa ggtcgtgttc 2580 caggagttca ctgacgggag cttcactcag cctttgtacc ggggagaact caatgaacat 2640 ctcggcctcc tcggacctta catcagagca gaagtggaag ataacatcat ggtcactttc 2700 cgtaaccaag ccagccgccc gtactcgttc tactcctccc tcatttctta cgaagaggac 2760 cagcggcagg gcgcagaacc gcgcaagaac ttcgtgaagc ccaacgaaac caagacctac 2820 ttctggaaag tgcagcatca tatggccccg actaaggacg agtttgactg caaagcctgg 2880 gcctacttct ccgatgtgga cttggagaag gacgtccact ccggcctcat cggtcccctg 2940 ctcgtgtgcc ataccaatac cctgaacccc gcacacggtc gccaggtcac cgtgcaggag 3000 ttcgctctgt tcttcactat cttcgacgaa actaagtcct ggtacttcac cgagaacatg 3060 gagaggaact gcagagcccc ctgtaacatc cagatggagg acccgacgtt caaggaaaac 3120 taccggttcc acgccattaa cggatacatc atggatacgc tgccgggtct tgtgatggcc 3180 caggatcaac ggatcagatg gtacttattg tcgatgggca gcaacgagaa catccactct 3240 attcacttct ccggtcatgt gttcactgtg cggaagaagg aagagtacaa gatggccctg 3300 tacaaccttt atcccggagt gttcgaaact gtggaaatgc tgccgtcgaa ggccggcatt 3360 tggcgcgtgg agtgtttgat tggagaacat ctccatgcgg ggatgtcaac cctgttcctg 3420 gtgtatagca acaagtgcca gactccgctt gggatggcgt caggacacat tagggatttc 3480 cagatcactg cgtccggcca gtacggccaa tgggccccta agctggcccg cctgcattac 3540 tccggatcca ttaacgcctg gtcaaccaag gagccattct cctggatcaa ggtggacctt 3600 ctggccccca tgattatcca cggaattaag acccaggggg cccggcagaa gttctcctca 3660 ctgtacatca gccagttcat aatcatgtac tccctggacg gaaagaagtg gcaaacctac 3720 agggggaaca gcaccggcac actgatggtc tttttcggaa atgtggactc ctccgggatt 3780 aagcataaca tcttcaaccc tccgattatc gctcggtaca ttagacttca ccctacccac 3840 tacagcattc gctccaccct gcggatggaa ctgatgggct gcgatctgaa ctcgtgcagc 3900 atgccgttgg gaatggagtc caaagcaatt tccgacgcgc agatcaccgc ctcgtcctac 3960 tttaccaaca tgttcgccac gtggtcaccg tccaaggccc ggctgcacct ccagggaaga 4020 tccaacgcat ggcggccaca ggtcaacaac cctaaggagt ggctccaggt ggacttccag 4080 aaaaccatga aggtcaccgg agtcacaacc cagggagtga agtcgctgct gacttctatg 4140 tacgtcaagg agttcctgat ctccagcagc caggacgggc accagtggac cctgttcttc 4200 caaaatggaa aggtcaaggt gtttcagggc aatcaggatt cattcacccc ggtggtgaac 4260 tcccttgatc cacccctcct gacccgctac cttcgcatcc acccacagtc ctgggtgcac 4320 cagatcgcgc tgaggatgga ggtcctggga tgcgaagccc aggacctgta ctga 4374 <210> 2 <211> 4374 <212> ADN <213> Secuencia Artificial <220> <223> coFVIII-4 <400> 2 atgcagatcg agctgagcac gtgcttcttc ctgtgcctgc tgaggttctg cttcagcgcc 60 accaggaggt actacctggg cgccgtggag ctgagctggg actacatgca gagcgacctg 120 ggcgagctgc ccgtggacgc caggttcccc cccagggtgc ccaagagctt ccccttcaac 180 acgagcgtgg tgtacaagaa gaccctgttc gtggagttca ccgaccatct gttcaatatc 240 gccaagccca ggcccccctg gatggggctg ctggggccca cgatccaggc cgaggtgtac 300 gacaccgtgg tcatcaccct gaagaacatg gccagccacc ccgtgagcct gcacgccgtg 360 ggcgtgagct actggaaggc cagcgagggc gccgagtacg acgaccagac cagccagagg 420 gagaaggagg acgacaaggt gttccccggc ggcagccaca cctacgtgtg gcaggtgctg 480 aaggagaatg ggcccatggc cagcgacccc ctgtgcctga cctactctta cctgagccac 540 gtggatctgg tgaaggacct gaacagcggc ctgatcggcg ccctgctggt gtgcagggag 600 ggcagcctgg ccaaggagaa gacccagacc ctgcacaagt tcatcctgct gttcgccgtg 660 ttcgacgagg gcaagagctg gcacagcgag accaagaaca gcctgatgca ggatagggac 720 gccgccagcg ccagggcctg gcccaagatg cacaccgtga acggctacgt gaacaggtct 780 ctgcccggcc tgatcggctg ccacaggaag agcgtgtact ggcacgtgat cggcatgggg 840 accacccccg aggtgcacag catcttcctg gagggccaca cgttcctggt gaggaatcac 900 aggcaggcca gcctggagat cagcccgatc accttcctga ccgcccagac cctgctgatg 960 gacctggggc agttcctgct gttctgccat atcagctctc accagcacga cggcatggag 1020 gcctacgtga aggtggatag ctgccccgag gagccccagc tgaggatgaa gaacaacgag 1080 gaggccgagg actacgacga cgacctgacc gacagcgaga tggacgtggt gaggttcgac 1140 gacgacaata gcccgagctt catccagatc aggagcgtgg ccaagaagca ccccaagacc 1200 tgggtgcatt acatcgccgc cgaggaggag gattgggact acgcccccct ggtgctggcc 1260 cccgacgaca ggtcttacaa gagccagtac ctgaacaacg ggccccagag gatcggcagg 1320 aagtacaaga aggtgaggtt catggcctac accgacgaga ccttcaagac cagggaggcg 1380 atccagcacg agagcgggat cctggggccc ctgctgtacg gcgaggtggg cgacacgctg 1440 ctgatcatct tcaagaacca ggccagcagg ccgtacaata tctaccccca cgggatcacc 1500 gacgtgaggc ccctgtactc taggaggctg cccaagggcg tgaagcacct gaaggacttc 1560 cccatcctgc ccggcgagat cttcaagtac aagtggaccg tgaccgtgga ggacgggccc 1620 acgaagagcg accccaggtg cctgaccagg tactacagct ctttcgtgaa catggagagg 1680 gacctggcca gcggcctgat cgggcccctg ctgatctgct acaaggagag cgtggatcag 1740 aggggcaacc agatcatgag cgacaagagg aacgtgatcc tgttcagcgt gttcgacgag 1800 aataggtctt ggtacctgac cgagaatatc cagaggttcc tgcccaaccc cgccggcgtg 1860 cagctggagg atcccgagtt ccaggccagc aacatcatgc acagcatcaa cggctacgtg 1920 ttcgacagcc tgcagctgag cgtgtgcctg cacgaggtgg cctactggta catcctgagc 1980 atcggcgccc agaccgactt cctgagcgtg ttcttcagcg gctacacctt caagcacaag 2040 atggtgtacg aggataccct gaccctgttc cccttcagcg gcgagaccgt gttcatgagc 2100 atggagaacc ccggcctgtg gatcctgggc tgccataact ccgacttcag gaataggggc 2160 atgaccgccc tgctgaaggt gagctcttgc gacaagaaca ccggcgacta ctacgaggat 2220 agctacgagg atatcagcgc ctacctgctg agcaagaaca acgccatcga gcccaggtct 2280 ttcagccaga acccccccgt gctgaagagg caccagaggg agatcaccag gacgaccctg 2340 cagagcgacc aggaggagat cgactacgac gacacgatca gcgtggagat gaagaaggag 2400 gatttcgaca tctacgacga ggacgagaat cagagcccca ggtctttcca gaagaagacc 2460 aggcattact tcatcgccgc cgtggagagg ctgtgggact acggcatgag cagctctccc 2520 cacgtgctga ggaatagggc ccagagcggc agcgtgcccc agttcaagaa ggtggtgttc 2580 caggagttca ccgacggcag cttcacccag cccctgtaca ggggcgagct gaacgagcac 2640 ctgggcctgc tggggcccta catcagggcc gaggtggagg ataacatcat ggtgaccttc 2700 aggaatcagg ccagcaggcc ctatagcttc tatagctctc tgatcagcta cgaggaggat 2760 cagaggcagg gcgccgagcc caggaagaac ttcgtgaagc ccaacgagac caagacctac 2820 ttctggaagg tgcagcacca catggccccc acgaaggacg agttcgactg caaggcctgg 2880 gcctacttca gcgacgtgga tctggagaag gacgtgcaca gcggcctgat cgggcccctg 2940 ctggtgtgcc acaccaacac cctgaacccc gcccacggca ggcaggtgac cgtgcaggag 3000 ttcgccctgt tcttcaccat cttcgacgag accaagagct ggtacttcac cgagaatatg 3060 gagaggaatt gcagggcccc ctgcaatatc cagatggagg acccgacctt caaggagaat 3120 tacaggttcc acgccatcaa cggctacatc atggacacgc tgcccggcct ggtcatggcc 3180 caggatcaga ggatcaggtg gtatctgctg agcatgggga gcaacgagaa tatccacagc 3240 atccacttca gcggccacgt gttcaccgtg aggaagaagg aggagtacaa gatggccctg 3300 tacaatctgt accccggcgt gttcgagacc gtggagatgc tgcccagcaa ggccgggatc 3360 tggagggtgg agtgcctgat cggcgagcac ctgcacgccg gcatgagcac gctgttcctg 3420 gtgtactcta acaagtgcca gacccccctg gggatggcca gcggccacat cagggacttc 3480 cagatcaccg ccagcggcca gtacggccag tgggccccca agctggccag gctgcactat 3540 tccggaagca tcaacgcctg gagcacgaag gagcccttca gctggatcaa ggtggatctg 3600 ctggccccca tgatcatcca cgggatcaag acccagggcg ccaggcagaa gttcagctct 3660 ctgtatatca gccagttcat catcatgtac tctctggacg gcaagaagtg gcagacctac 3720 aggggcaaca gcaccggcac gctgatggtg ttcttcggca acgtggactc tagcgggatc 3780 aagcacaata tcttcaaccc ccccatcatc gccaggtaca tcaggctgca ccccacccat 3840 tactctatca ggtctaccct gaggatggag ctgatgggct gcgacctgaa cagctgcagc 3900 atgcccctgg ggatggagag caaggccatc agcgacgccc agatcaccgc cagctcttac 3960 ttcaccaaca tgttcgccac ctggagcccg agcaaggcca ggctgcacct gcagggcagg 4020 tctaacgcct ggaggcccca ggtgaacaac cccaaggagt ggctgcaggt ggatttccag 4080 aagaccatga aggtgaccgg cgtgaccacg cagggcgtga agagcctgct gaccagcatg 4140 tacgtgaagg agttcctgat cagctctagc caggacggcc accagtggac cctgttcttc 4200 cagaacggca aggtgaaggt gttccagggc aaccaggata gcttcacccc cgtggtgaac 4260 agcctggacc cccccctgct gaccaggtat ctgaggatcc acccccagag ctgggtgcac 4320 cagatcgccc tgaggatgga ggtgctgggc tgcgaggccc aggatctgta ttga 4374 <210> 3 <211> 4374 <212> ADN <213> Secuencia Artificial <220> <223> coFVIII-52 <400> 3 atgcaaatcg aactgagcac ctgtttcttc ctctgcctgc tgagattctg tttctccgcg 60 acccgccgat actacctggg agcagtggag ctctcctggg attacatgca gagcgacctt 120 ggggagctgc ccgtggatgc caggttccct ccccgggtgc caaagtcgtt tccgttcaac 180 acctccgtgg tgtacaagaa aactctgttc gtggagttca ccgaccacct gttcaatatc 240 gccaagccca gacctccctg gatggggctg ttgggaccta ccatccaagc ggaggtgtac 300 gacactgtgg tcatcactct gaagaacatg gcctcgcatc ccgtgtccct gcacgccgtg 360 ggagtgtctt actggaaagc gtccgagggg gccgaatacg acgaccagac ctcgcagaga 420 gaaaaggaag atgacaaggt gttcccagga ggatcgcaca cctacgtgtg gcaagtgttg 480 aaggagaacg gcccaatggc ctccgacccg ctgtgcctga cctactcgta cctgtcccac 540 gtggacctcg tgaaggacct caactcggga ctgattggag ccctgctggt ctgcagggaa 600 ggctcactgg cgaaagaaaa gactcagacc ttgcacaagt tcattctgct gttcgctgtg 660 ttcgacgagg ggaagtcgtg gcacagcgag actaagaact ccctgatgca agatagagat 720 gccgcctccg cccgggcctg gcctaagatg cacaccgtga acggttacgt gaaccgctcc 780 ctccctggcc tgattggatg ccaccggaag tccgtgtact ggcacgtgat cgggatgggg 840 accacccccg aggtgcacag catcttcctg gaaggtcaca catttctcgt gcgcaaccac 900 cggcaggcct ccctggaaat cagccccatt accttcctca ctgcccagac tctgctgatg 960 gacctgggac agttcctgct gttctgccat atctcctccc accaacatga cggaatggag 1020 gcatacgtga aggtcgattc ctgccctgag gaaccccagc tccgcatgaa gaacaatgag 1080 gaagccgagg actacgacga cgacctgacg gatagcgaga tggatgtggt ccggttcgat 1140 gacgataaca gcccttcctt catccaaatt cgctcggtgg caaagaagca ccccaagacc 1200 tgggtgcatt acattgcggc ggaagaagag gactgggatt atgccccgct tgtcctcgct 1260 cctgacgacc ggagctacaa gagccagtac ctgaacaacg gtccacagag gatcggtaga 1320 aagtacaaga aggtccgctt catggcctat accgacgaaa ccttcaaaac tagagaggcc 1380 atccaacacg aatccggcat cctgggcccg ctcttgtacg gagaagtcgg cgacaccctt 1440 ctcattatct tcaagaacca ggcttcccgg ccgtacaaca tctatccgca tgggatcact 1500 gacgtgcgcc cactgtactc gcggcgcctg cccaagggtg tcaaacacct gaaggatttt 1560 ccgatccttc cgggagaaat cttcaagtac aagtggaccg tgaccgtgga agatggccca 1620 actaagtctg accctagatg cctcacccgc tactactcat ccttcgtcaa catggagcgc 1680 gacctggcca gcggactgat cggcccgctg ctgatttgct acaaggaatc agtggaccaa 1740 cggggaaacc agatcatgtc ggataagagg aacgtcatcc tcttctccgt gtttgacgaa 1800 aaccggtcgt ggtacctgac cgagaacatc cagaggttcc tgcccaaccc tgctggggtg 1860 cagctggagg accccgagtt ccaggccagc aacatcatgc acagcatcaa tggctacgtg 1920 ttcgacagcc tgcagctgag cgtgtgcctg cacgaggtgg cctactggta catcctgagc 1980 atcggcgccc agaccgactt cctgagcgtg ttcttctctg gctacacctt caagcacaag 2040 atggtgtatg aggacaccct gaccctgttc cccttcagcg gggagactgt cttcatgagc 2100 atggagaacc ctggcctgtg gatcctgggc tgccacaaca gcgacttcag gaacaggggc 2160 atgactgccc tgctgaaagt ctccagctgt gacaagaaca ccggggacta ctacgaggac 2220 agctacgagg acatcagcgc ctacctgctg agcaagaaca atgccatcga gcccaggagc 2280 ttctctcaga accccccagt gctgaagagg caccagaggg agatcaccag gaccaccctg 2340 cagtctgacc aggaggagat cgactatgat gacaccatca gcgtggagat gaagaaggag 2400 gacttcgaca tctacgacga ggacgagaac cagagcccca ggagcttcca gaagaagacc 2460 aggcactact tcattgctgc tgtggagagg ctgtgggact atggcatgtc cagcagcccc 2520 catgtgctga ggaacagggc ccagtctggc agcgtgcccc agttcaagaa agtcgtgttc 2580 caggagttca ccgacggcag cttcacccag cccctgtaca gaggggagct gaacgagcac 2640 ctgggcctgc tgggccccta catcagggcc gaggtggagg acaacatcat ggtgaccttc 2700 aggaaccagg ccagcaggcc ctacagcttc tacagcagcc tgatcagcta cgaggaggac 2760 cagaggcagg gggctgagcc caggaagaac tttgtgaagc ccaatgaaac caagacctac 2820 ttctggaagg tgcagcacca catggccccc accaaggacg agttcgactg caaggcctgg 2880 gcctacttct ctgacgtgga cctggagaag gacgtgcact ctggcctgat tggccccctg 2940 ctggtgtgcc acaccaacac cctgaaccct gcccatggca ggcaggtgac tgtgcaggag 3000 ttcgccctgt tcttcaccat cttcgatgaa accaagagct ggtacttcac tgagaacatg 3060 gagaggaact gcagggcccc ctgcaacatc cagatggagg accccacctt caaggagaac 3120 tacaggttcc atgccatcaa tggctacatc atggacaccc tgcctggcct ggtcatggcc 3180 caggaccaga ggatcaggtg gtatctgctg agcatgggca gcaacgagaa catccacagc 3240 atccacttct ctggccacgt gttcactgtg aggaagaagg aggagtacaa gatggccctg 3300 tacaacctgt accctggggt gttcgaaacc gtggagatgc tgcccagcaa ggccggcatc 3360 tggagggtgg agtgcctgat tggggagcac ctgcacgccg gcatgagcac cctgttcctg 3420 gtgtacagca acaagtgcca gacccccctg ggcatggcct ctggccacat cagggacttc 3480 cagatcactg cctctggcca gtacggccag tgggccccca agctggccag gctgcactac 3540 tccggaagca tcaatgcctg gagcaccaag gagcccttca gctggatcaa agtggacctg 3600 ctggccccca tgatcatcca cggcatcaag acccaggggg ccaggcagaa gttctccagc 3660 ctgtacatca gccagttcat catcatgtac agcctggacg gcaagaagtg gcagacctac 3720 aggggcaaca gcaccggcac cctgatggtg ttcttcggca acgtggacag cagcggcatc 3780 aagcacaaca tcttcaaccc ccccatcatc gccagataca tcaggctgca ccccacccac 3840 tacagcatca ggagcaccct gaggatggag ctgatgggct gtgacctgaa cagctgcagc 3900 atgcccctgg gcatggagag caaggccatc tctgacgccc agatcactgc ctccagctac 3960 ttcaccaaca tgtttgccac ctggagcccc agcaaggcca ggctgcacct gcagggcagg 4020 agcaatgcct ggaggcccca ggtcaacaac cccaaggagt ggctgcaggt ggacttccag 4080 aagaccatga aggtgactgg ggtgaccacc cagggggtga agagcctgct gaccagcatg 4140 tacgtgaagg agttcctgat ctccagcagc caggacggcc accagtggac cctgttcttc 4200 cagaatggca aggtgaaggt gttccagggc aaccaggaca gcttcacccc tgtggtcaac 4260 agcctggacc cccccctgct gaccagatac ctgaggatcc acccccagag ctgggtgcac 4320 cagatcgccc tgaggatgga ggtgctgggc tgtgaggccc aggacctgta ctga 4374 <210> 4 <211> 4374 <212> ADN <213> Secuencia Artificial <220> <223> coFVIII-62 <400> 4 atgcagattg agctgtccac ttgtttcttc ctgtgcctcc tgcgcttctg tttctccgcc 60 actcgccggt actaccttgg agccgtggag ctttcatggg actacatgca gagcgacctg 120 ggcgaactcc ccgtggatgc cagattcccc ccccgcgtgc caaagtcctt cccctttaac 180 acctccgtgg tgtacaagaa aaccctcttt gtcgagttca ctgaccacct gttcaacatc 240 gccaagccgc gcccaccttg gatgggcctc ctgggaccga ccattcaagc tgaagtgtac 300 gacaccgtgg tgatcaccct gaagaacatg gcgtcccacc ccgtgtccct gcatgcggtc 360 ggagtgtcct actggaaggc ctccgaagga gctgagtacg acgaccagac tagccagcgg 420 gaaaaggagg acgataaagt gttcccgggc ggctcgcata cttacgtgtg gcaagtcctg 480 aaggaaaacg gacctatggc atccgatcct ctgtgcctga cttactccta cctttcccat 540 gtggacctcg tgaaggacct gaacagcggg ctgattggtg cacttctcgt gtgccgcgaa 600 ggttcgctcg ctaaggaaaa gacccagacc ctccataagt tcatcctttt gttcgctgtg 660 ttcgatgaag gaaagtcatg gcattccgaa actaagaact cgctgatgca ggaccgggat 720 gccgcctcag cccgcgcctg gcctaaaatg catacagtca acggatacgt gaatcggtca 780 ctgcccgggc tcatcggttg tcacagaaag tccgtgtact ggcacgtcat cggcatgggc 840 actacgcctg aagtgcactc catcttcctg gaagggcaca ccttcctcgt gcgcaaccac 900 cgccaggcct ctctggaaat ctccccgatt acctttctga ccgcccagac tctgctcatg 960 gacctggggc agttccttct cttctgccac atctccagcc atcagcacga cggaatggag 1020 gcctacgtga aggtggactc atgcccggaa gaacctcagt tgcggatgaa gaacaacgag 1080 gaggccgagg actatgacga cgatttgact gactccgaga tggacgtcgt gcggttcgat 1140 gacgacaaca gccccagctt catccagatt cgcagcgtgg ccaagaagca ccccaaaacc 1200 tgggtgcact acatcgcggc cgaggaagaa gattgggact acgccccgtt ggtgctggca 1260 cccgatgacc ggtcgtacaa gtcccagtat ctgaacaatg gtccgcagcg gattggcaga 1320 aagtacaaga aagtgcggtt catggcgtac actgacgaaa cgtttaagac ccgggaggcc 1380 attcaacatg agagcggcat tctgggacca ctgctgtacg gagaggtcgg cgataccctg 1440 ctcatcatct tcaaaaacca ggcctcccgg ccttacaaca tctaccctca cggaatcacc 1500 gacgtgcggc cactctactc gcggcgcctg ccgaagggcg tcaagcacct gaaagacttc 1560 cctatcctgc cgggcgaaat cttcaagtat aagtggaccg tcaccgtgga ggacgggccc 1620 accaagagcg atcctaggtg tctgactcgg tactactcca gcttcgtgaa catggaacgg 1680 gacctggcat cgggactcat tggaccgctg ctgatctgct acaaagagtc ggtggatcaa 1740 cgcggcaacc agatcatgtc cgacaagcgc aacgtgatcc tgttctccgt gtttgatgaa 1800 aacagatcct ggtacctgac cgagaacatc cagaggttcc tgcccaaccc tgctggggtg 1860 cagctggagg accccgagtt ccaggccagc aacatcatgc acagcatcaa tggctacgtg 1920 ttcgacagcc tgcagctgag cgtgtgcctg cacgaggtgg cctactggta catcctgagc 1980 atcggcgccc agaccgactt cctgagcgtg ttcttctctg gctacacctt caagcacaag 2040 atggtgtatg aggacaccct gaccctgttc cccttcagcg gggagactgt cttcatgagc 2100 atggagaacc ctggcctgtg gatcctgggc tgccacaaca gcgacttcag gaacaggggc 2160 atgactgccc tgctgaaagt ctccagctgt gacaagaaca ccggggacta ctacgaggac 2220 agctacgagg acatcagcgc ctacctgctg agcaagaaca atgccatcga gcccaggagc 2280 ttctctcaga accccccagt gctgaagagg caccagaggg agatcaccag gaccaccctg 2340 cagtctgacc aggaggagat cgactatgat gacaccatca gcgtggagat gaagaaggag 2400 gacttcgaca tctacgacga ggacgagaac cagagcccca ggagcttcca gaagaagacc 2460 aggcactact tcattgctgc tgtggagagg ctgtgggact atggcatgtc cagcagcccc 2520 catgtgctga ggaacagggc ccagtctggc agcgtgcccc agttcaagaa agtcgtgttc 2580 caggagttca ccgacggcag cttcacccag cccctgtaca gaggggagct gaacgagcac 2640 ctgggcctgc tgggccccta catcagggcc gaggtggagg acaacatcat ggtgaccttc 2700 aggaaccagg ccagcaggcc ctacagcttc tacagcagcc tgatcagcta cgaggaggac 2760 cagaggcagg gggctgagcc caggaagaac tttgtgaagc ccaatgaaac caagacctac 2820 ttctggaagg tgcagcacca catggccccc accaaggacg agttcgactg caaggcctgg 2880 gcctacttct ctgacgtgga cctggagaag gacgtgcact ctggcctgat tggccccctg 2940 ctggtgtgcc acaccaacac cctgaaccct gcccatggca ggcaggtgac tgtgcaggag 3000 ttcgccctgt tcttcaccat cttcgatgaa accaagagct ggtacttcac tgagaacatg 3060 gagaggaact gcagggcccc ctgcaacatc cagatggagg accccacctt caaggagaac 3120 tacaggttcc atgccatcaa tggctacatc atggacaccc tgcctggcct ggtcatggcc 3180 caggaccaga ggatcaggtg gtatctgctg agcatgggca gcaacgagaa catccacagc 3240 atccacttct ctggccacgt gttcactgtg aggaagaagg aggagtacaa gatggccctg 3300 tacaacctgt accctggggt gttcgaaacc gtggagatgc tgcccagcaa ggccggcatc 3360 tggagggtgg agtgcctgat tggggagcac ctgcacgccg gcatgagcac cctgttcctg 3420 gtgtacagca acaagtgcca gacccccctg ggcatggcct ctggccacat cagggacttc 3480 cagatcactg cctctggcca gtacggccag tgggccccca agctggccag gctgcactac 3540 tccggaagca tcaatgcctg gagcaccaag gagcccttca gctggatcaa agtggacctg 3600 ctggccccca tgatcatcca cggcatcaag acccaggggg ccaggcagaa gttctccagc 3660 ctgtacatca gccagttcat catcatgtac agcctggacg gcaagaagtg gcagacctac 3720 aggggcaaca gcaccggcac cctgatggtg ttcttcggca acgtggacag cagcggcatc 3780 aagcacaaca tcttcaaccc ccccatcatc gccagataca tcaggctgca ccccacccac 3840 tacagcatca ggagcaccct gaggatggag ctgatgggct gtgacctgaa cagctgcagc 3900 atgcccctgg gcatggagag caaggccatc tctgacgccc agatcactgc ctccagctac 3960 ttcaccaaca tgtttgccac ctggagcccc agcaaggcca ggctgcacct gcagggcagg 4020 agcaatgcct ggaggcccca ggtcaacaac cccaaggagt ggctgcaggt ggacttccag 4080 aagaccatga aggtgactgg ggtgaccacc cagggggtga agagcctgct gaccagcatg 4140 tacgtgaagg agttcctgat ctccagcagc caggacggcc accagtggac cctgttcttc 4200 cagaatggca aggtgaaggt gttccagggc aaccaggaca gcttcacccc tgtggtcaac 4260 agcctggacc cccccctgct gaccagatac ctgaggatcc acccccagag ctgggtgcac 4320 cagatcgccc tgaggatgga ggtgctgggc tgtgaggccc aggacctgta ctga 4374 <210> 5 <211> 4374 <212> ADN <213> Secuencia Artificial <220> <223> coFVIII-25 <400> 5 atgcagattg agctgagcac ctgcttcttc ctgtgcctgc tgaggttctg cttctctgcc 60 accaggagat actacctggg cgccgtggag ctgagctggg actacatgca gtctgacctg 120 ggcgagctgc cagtggacgc caggttcccc cccagagtgc ccaagagctt ccccttcaac 180 accagcgtgg tgtacaagaa gaccctgttc gtggagttca ctgaccacct gttcaacatc 240 gccaagccca ggcccccctg gatgggcctg ctgggcccca ccatccaggc cgaggtgtac 300 gacaccgtgg tcatcaccct gaagaacatg gccagccacc ccgtctccct gcacgccgtg 360 ggggtgagct actggaaggc ctctgagggc gccgagtacg acgaccagac cagccagagg 420 gagaaggagg acgacaaggt gttccctggg ggcagccaca cctacgtgtg gcaggtcctg 480 aaggagaacg gccccatggc ctctgacccc ctgtgcctga cctacagcta cctgagccac 540 gtggacctgg tgaaggacct gaactctggc ctgattgggg ccctgctggt gtgcagggag 600 ggcagcctgg ccaaggagaa gacccagacc ctgcacaagt tcatcctgct gttcgccgtg 660 ttcgacgagg gcaagagctg gcactctgaa accaagaaca gcctgatgca ggacagggac 720 gccgcctctg ccagggcctg gcccaagatg cacaccgtca acggctacgt caacaggagc 780 ctgcctggcc tgattggctg ccacaggaag agcgtgtact ggcatgtgat cggcatgggc 840 accacccctg aggtgcacag catcttcctg gagggccaca ccttcctggt caggaaccac 900 aggcaggcca gcctggagat cagccccatc accttcctga ccgcccagac cctgctgatg 960 gacctgggcc agttcctgct gttctgccac atctccagcc accagcacga cggcatggag 1020 gcctacgtga aagtggacag ctgccctgag gagccccagc tgaggatgaa gaacaacgag 1080 gaggccgagg actatgatga cgacctgacc gacagcgaga tggacgtggt caggttcgac 1140 gacgacaaca gccccagctt catccagatc aggagcgtgg ccaagaagca ccccaagacc 1200 tgggtgcact acatcgctgc tgaggaggag gactgggact atgcccccct ggtgctggcc 1260 cctgatgaca ggagctacaa gagccagtac ctgaacaatg gcccccagag gattggcagg 1320 aagtacaaga aagtcaggtt catggcctac actgatgaaa ccttcaagac cagggaggcc 1380 atccagcatg agtctggcat cctgggcccc ctgctgtacg gggaggtggg ggacaccctg 1440 ctgatcatct tcaagaacca ggccagcagg ccctacaaca tctaccccca tggcatcacc 1500 gacgtgaggc ccctgtacag caggaggctg cctaaggggg tgaagcacct gaaagacttc 1560 cccatcctgc ctggggagat cttcaagtac aagtggactg tgactgtgga ggacggcccc 1620 accaagagcg accccaggtg cctgaccaga tactacagca gcttcgtcaa catggagagg 1680 gacctggcct ctggcctgat tggccccctg ctgatctgct acaaggagtc tgtggaccag 1740 aggggcaacc agatcatgag cgacaagagg aacgtgatcc tgttctctgt cttcgacgag 1800 aacaggagct ggtacctgac tgaaaacatc cagcggttcc tccccaaccc cgcgggcgtg 1860 cagctggaag atcctgagtt tcaggcatca aacatcatgc actccattaa cggctacgtg 1920 ttcgattcgc tgcagctgag cgtgtgtctg cacgaagtgg cctactggta catcctgtcc 1980 attggtgccc agactgactt cctgtccgtg tttttctccg gctacacgtt caagcacaag 2040 atggtgtacg aggacaccct gaccctcttc cctttttccg gcgaaactgt gtttatgagc 2100 atggagaatc ccggcctgtg gatcttgggc tgccacaaca gcgacttccg taacagagga 2160 atgactgcgc tgctcaaggt gtccagctgc gacaagaaca ccggagacta ttatgaggac 2220 tcatacgagg acatctccgc ctacctcctg tccaagaata acgccattga acctcggagc 2280 ttcagccaga acccacccgt gcttaagaga catcaacggg agatcactag gaccaccctg 2340 cagtcagacc aggaggaaat cgactacgat gacaccatct cggtcgagat gaagaaggag 2400 gactttgaca tctacgacga agatgaaaac cagagcccga ggtcgttcca aaagaaaacc 2460 cgccactact ttattgctgc tgtcgagcgg ctgtgggact acggaatgtc gtcctcgccg 2520 cacgtgctcc gcaaccgagc ccagagcggc tcggtgccgc aattcaagaa ggtcgtgttc 2580 caggagttca ctgacgggag cttcactcag cctttgtacc ggggagaact caatgaacat 2640 ctcggcctcc tcggacctta catcagagca gaagtggaag ataacatcat ggtcactttc 2700 cgtaaccaag ccagccgccc gtactcgttc tactcctccc tcatttctta cgaagaggac 2760 cagcggcagg gcgcagaacc gcgcaagaac ttcgtgaagc ccaacgaaac caagacctac 2820 ttctggaaag tgcagcatca tatggccccg actaaggacg agtttgactg caaagcctgg 2880 gcctacttct ccgatgtgga cttggagaag gacgtccact ccggcctcat cggtcccctg 2940 ctcgtgtgcc ataccaatac cctgaacccc gcacacggtc gccaggtcac cgtgcaggag 3000 ttcgctctgt tcttcactat cttcgacgaa actaagtcct ggtacttcac cgagaacatg 3060 gagaggaact gcagagcccc ctgtaacatc cagatggagg acccgacgtt caaggaaaac 3120 taccggttcc acgccattaa cggatacatc atggatacgc tgccgggtct tgtgatggcc 3180 caggatcaac ggatcagatg gtacttattg tcgatgggca gcaacgagaa catccactct 3240 attcacttct ccggtcatgt gttcactgtg cggaagaagg aagagtacaa gatggccctg 3300 tacaaccttt atcccggagt gttcgaaact gtggaaatgc tgccgtcgaa ggccggcatt 3360 tggcgcgtgg agtgtttgat tggagaacat ctccatgcgg ggatgtcaac cctgttcctg 3420 gtgtatagca acaagtgcca gactccgctt gggatggcgt caggacacat tagggatttc 3480 cagatcactg cgtccggcca gtacggccaa tgggccccta agctggcccg cctgcattac 3540 tccggatcca ttaacgcctg gtcaaccaag gagccattct cctggatcaa ggtggacctt 3600 ctggccccca tgattatcca cggaattaag acccaggggg cccggcagaa gttctcctca 3660 ctgtacatca gccagttcat aatcatgtac tccctggacg gaaagaagtg gcaaacctac 3720 agggggaaca gcaccggcac actgatggtc tttttcggaa atgtggactc ctccgggatt 3780 aagcataaca tcttcaaccc tccgattatc gctcggtaca ttagacttca ccctacccac 3840 tacagcattc gctccaccct gcggatggaa ctgatgggct gcgatctgaa ctcgtgcagc 3900 atgccgttgg gaatggagtc caaagcaatt tccgacgcgc agatcaccgc ctcgtcctac 3960 tttaccaaca tgttcgccac gtggtcaccg tccaaggccc ggctgcacct ccagggaaga 4020 tccaacgcat ggcggccaca ggtcaacaac cctaaggagt ggctccaggt ggacttccag 4080 aaaaccatga aggtcaccgg agtcacaacc cagggagtga agtcgctgct gacttctatg 4140 tacgtcaagg agttcctgat ctccagcagc caggacgggc accagtggac cctgttcttc 4200 caaaatggaa aggtcaaggt gtttcagggc aatcaggatt cattcacccc ggtggtgaac 4260 tcccttgatc cacccctcct gacccgctac cttcgcatcc acccacagtc ctgggtgcac 4320 cagatcgcgc tgaggatgga ggtcctggga tgcgaagccc aggacctgta ctga 4374 <210> 6 <211> 4374 <212> ADN <213> Secuencia Artificial <220> <223> coFVIII-26 <400> 6 atgcagattg agctgagcac ctgcttcttc ctgtgcctgc tgaggttctg cttctctgcc 60 accaggagat actacctggg cgccgtggag ctgagctggg actacatgca gtctgacctg 120 ggcgagctgc cagtggacgc caggttcccc cccagagtgc ccaagagctt ccccttcaac 180 accagcgtgg tgtacaagaa gaccctgttc gtggagttca ctgaccacct gttcaacatc 240 gccaagccca ggcccccctg gatgggcctg ctgggcccca ccatccaggc cgaggtgtac 300 gacaccgtgg tcatcaccct gaagaacatg gccagccacc ccgtctccct gcacgccgtg 360 ggggtgagct actggaaggc ctctgagggc gccgagtacg acgaccagac cagccagagg 420 gagaaggagg acgacaaggt gttccctggg ggcagccaca cctacgtgtg gcaggtcctg 480 aaggagaacg gccccatggc ctctgacccc ctgtgcctga cctacagcta cctgagccac 540 gtggacctgg tgaaggacct gaactctggc ctgattgggg ccctgctggt gtgcagggag 600 ggcagcctgg ccaaggagaa gacccagacc ctgcacaagt tcatcctgct gttcgccgtg 660 ttcgacgagg gcaagagctg gcactctgaa accaagaaca gcctgatgca ggacagggac 720 gccgcctctg ccagggcctg gcccaagatg cacaccgtca acggctacgt caacaggagc 780 ctgcctggcc tgattggctg ccacaggaag agcgtgtact ggcatgtgat cggcatgggc 840 accacccctg aggtgcacag catcttcctg gagggccaca ccttcctggt caggaaccac 900 aggcaggcca gcctggagat cagccccatc accttcctga ccgcccagac cctgctgatg 960 gacctgggcc agttcctgct gttctgccac atctccagcc accagcacga cggcatggag 1020 gcctacgtga aagtggacag ctgccctgag gagccccagc tgaggatgaa gaacaacgag 1080 gaggccgagg actatgatga cgacctgacc gacagcgaga tggacgtggt caggttcgac 1140 gacgacaaca gccccagctt catccagatc aggagcgtgg ccaagaagca ccccaagacc 1200 tgggtgcact acatcgctgc tgaggaggag gactgggact atgcccccct ggtgctggcc 1260 cctgatgaca ggagctacaa gagccagtac ctgaacaatg gcccccagag gattggcagg 1320 aagtacaaga aagtcaggtt catggcctac actgatgaaa ccttcaagac cagggaggcc 1380 atccagcatg agtctggcat cctgggcccc ctgctgtacg gggaggtggg ggacaccctg 1440 ctgatcatct tcaagaacca ggccagcagg ccctacaaca tctaccccca tggcatcacc 1500 gacgtgaggc ccctgtacag caggaggctg cctaaggggg tgaagcacct gaaagacttc 1560 cccatcctgc ctggggagat cttcaagtac aagtggactg tgactgtgga ggacggcccc 1620 accaagagcg accccaggtg cctgaccaga tactacagca gcttcgtcaa catggagagg 1680 gacctggcct ctggcctgat tggccccctg ctgatctgct acaaggagtc tgtggaccag 1740 aggggcaacc agatcatgag cgacaagagg aacgtgatcc tgttctctgt cttcgacgag 1800 aacaggagct ggtacctcac tgaaaacatc cagaggttcc tcccaaaccc cgcaggagtg 1860 caactggagg accctgagtt tcaggcctcg aatatcatgc actcgattaa cggttacgtg 1920 ttcgactcgc tgcagctgag cgtgtgcctc catgaagtcg cttactggta cattctgtcc 1980 atcggcgccc agactgactt cctgagcgtg ttcttttccg gttacacctt taagcacaag 2040 atggtgtacg aagataccct gaccctgttc cctttctccg gcgaaacggt gttcatgtcg 2100 atggagaacc cgggtctgtg gattctggga tgccacaaca gcgactttcg gaaccgcgga 2160 atgactgccc tgctgaaggt gtcctcatgc gacaagaaca ccggagacta ctacgaggac 2220 tcctacgagg atatctcagc ctacctcctg tccaagaaca acgcgatcga gccgcgcagc 2280 ttcagccaga acccgcctgt gctgaagagg caccagcgag aaattacccg gaccaccctc 2340 caatcggatc aggaggaaat cgactacgac gacaccatct cggtggaaat gaagaaggaa 2400 gatttcgata tctacgacga ggacgaaaat cagtcccctc gctcattcca aaagaaaact 2460 agacactact ttatcgccgc ggtggaaaga ctgtgggact atggaatgtc atccagccct 2520 cacgtccttc ggaaccgggc ccagagcgga tcggtgcctc agttcaagaa agtggtgttc 2580 caggagttca ccgacggcag cttcacccag ccgctgtacc ggggagaact gaacgaacac 2640 ctgggcctgc tcggtcccta catccgcgcg gaagtggagg ataacatcat ggtgaccttc 2700 cgtaaccaag catccagacc ttactccttc tattcctccc tgatctcata cgaggaggac 2760 cagcgccaag gcgccgagcc ccgcaagaac ttcgtcaagc ccaacgagac taagacctac 2820 ttctggaagg tccaacacca tatggccccg accaaggatg agtttgactg caaggcctgg 2880 gcctacttct ccgacgtgga ccttgagaag gatgtccatt ccggcctgat cgggccgctg 2940 ctcgtgtgtc acaccaacac cctgaaccca gcgcatggac gccaggtcac cgtccaggag 3000 tttgctctgt tcttcaccat ttttgacgaa actaagtcct ggtacttcac cgagaatatg 3060 gagcgaaact gtagagcgcc ctgcaatatc cagatggaag atccgacttt caaggagaac 3120 tatagattcc acgccatcaa cgggtacatc atggatactc tgccggggct ggtcatggcc 3180 caggatcaga ggattcggtg gtacttgctg tcaatgggat cgaacgaaaa cattcactcc 3240 attcacttct ccggtcacgt gttcactgtg cgcaagaagg aggagtacaa gatggcgctg 3300 tacaatctgt accccggggt gttcgaaact gtggagatgc tgccgtccaa ggccggcatc 3360 tggagagtgg agtgcctgat cggagagcac ctccacgcgg ggatgtccac cctcttcctg 3420 gtgtactcga ataagtgcca gaccccgctg ggcatggcct cgggccacat cagagacttc 3480 cagatcacag caagcggaca atacggccaa tgggcgccga agctggcccg cttgcactac 3540 tccggatcga tcaacgcatg gtccaccaag gaaccgttct cgtggattaa ggtggacctc 3600 ctggccccta tgattatcca cggaattaag acccagggcg ccaggcagaa gttctcctcc 3660 ctgtacatct cgcaattcat catcatgtac agcctggacg ggaagaagtg gcagacttac 3720 aggggaaact ccaccggcac cctgatggtc tttttcggca acgtggattc ctccggcatt 3780 aagcacaaca tcttcaaccc accgatcata gccagatata ttaggctcca ccccactcac 3840 tactcaatcc gctcaactct tcggatggaa ctcatggggt gcgacctgaa ctcctgctcc 3900 atgccgttgg ggatggaatc aaaggctatt agcgacgccc agatcaccgc gagctcctac 3960 ttcactaaca tgttcgccac ctggagcccc tccaaggcca ggctgcactt gcagggacgg 4020 tcaaatgcct ggcggccgca agtgaacaat ccgaaggaat ggcttcaagt ggatttccaa 4080 aagaccatga aagtgaccgg agtcaccacc cagggagtga agtcccttct gacctcgatg 4140 tatgtgaagg agttcctgat tagcagcagc caggacgggc accagtggac cctgttcttc 4200 caaaacggaa aggtcaaggt gttccagggg aaccaggact cgttcacacc cgtggtgaac 4260 tccctggacc ccccactgct gacgcggtac ttgaggattc atcctcagtc ctgggtccat 4320 cagattgcat tgcgaatgga agtcctgggc tgcgaggccc aggacctgta ctga 4374 <210> 7 <211> 1734 <212> ADN <213> Secuencia Artificial <220> <223> coFVIII-52-NT58 <400> 7 gcgacccgcc gatactacct gggagcagtg gagctctcct gggattacat gcagagcgac 60 cttggggagc tgcccgtgga tgccaggttc cctccccggg tgccaaagtc gtttccgttc 120 aacacctccg tggtgtacaa gaaaactctg ttcgtggagt tcaccgacca cctgttcaat 180 atcgccaagc ccagacctcc ctggatgggg ctgttgggac ctaccatcca agcggaggtg 240 tacgacactg tggtcatcac tctgaagaac atggcctcgc atcccgtgtc cctgcacgcc 300 gtgggagtgt cttactggaa agcgtccgag ggggccgaat acgacgacca gacctcgcag 360 agagaaaagg aagatgacaa ggtgttccca ggaggatcgc acacctacgt gtggcaagtg 420 ttgaaggaga acggcccaat ggcctccgac ccgctgtgcc tgacctactc gtacctgtcc 480 cacgtggacc tcgtgaagga cctcaactcg ggactgattg gagccctgct ggtctgcagg 540 gaaggctcac tggcgaaaga aaagactcag accttgcaca agttcattct gctgttcgct 600 gtgttcgacg aggggaagtc gtggcacagc gagactaaga actccctgat gcaagataga 660 gatgccgcct ccgcccgggc ctggcctaag atgcacaccg tgaacggtta cgtgaaccgc 720 tccctccctg gcctgattgg atgccaccgg aagtccgtgt actggcacgt gatcgggatg 780 gggaccaccc ccgaggtgca cagcatcttc ctggaaggtc acacatttct cgtgcgcaac 840 caccggcagg cctccctgga aatcagcccc attaccttcc tcactgccca gactctgctg 900 atggacctgg gacagttcct gctgttctgc catatctcct cccaccaaca tgacggaatg 960 gaggcatacg tgaaggtcga ttcctgccct gaggaacccc agctccgcat gaagaacaat 1020 gaggaagccg aggactacga cgacgacctg acggatagcg agatggatgt ggtccggttc 1080 gatgacgata acagcccttc cttcatccaa attcgctcgg tggcaaagaa gcaccccaag 1140 acctgggtgc attacattgc ggcggaagaa gaggactggg attatgcccc gcttgtcctc 1200 gctcctgacg accggagcta caagagccag tacctgaaca acggtccaca gaggatcggt 1260 agaaagtaca agaaggtccg cttcatggcc tataccgacg aaaccttcaa aactagagag 1320 gccatccaac acgaatccgg catcctgggc ccgctcttgt acggagaagt cggcgacacc 1380 cttctcatta tcttcaagaa ccaggcttcc cggccgtaca acatctatcc gcatgggatc 1440 actgacgtgc gcccactgta ctcgcggcgc ctgcccaagg gtgtcaaaca cctgaaggat 1500 tttccgatcc ttccgggaga aatcttcaag tacaagtgga ccgtgaccgt ggaagatggc 1560 ccaactaagt ctgaccctag atgcctcacc cgctactact catccttcgt caacatggag 1620 cgcgacctgg ccagcggact gatcggcccg ctgctgattt gctacaagga atcagtggac 1680 caacggggaa accagatcat gtcggataag aggaacgtca tcctcttctc cgtg 1734 <210> 8 <211> 2583 <212> ADN <213> Secuencia Artificial <220> <223> coFVIII-52-CT <400> 8 tttgacgaaa accggtcgtg gtacctgacc gagaacatcc agaggttcct gcccaaccct 60 gctggggtgc agctggagga ccccgagttc caggccagca acatcatgca cagcatcaat 120 ggctacgtgt tcgacagcct gcagctgagc gtgtgcctgc acgaggtggc ctactggtac 180 atcctgagca tcggcgccca gaccgacttc ctgagcgtgt tcttctctgg ctacaccttc 240 aagcacaaga tggtgtatga ggacaccctg accctgttcc ccttcagcgg ggagactgtc 300 ttcatgagca tggagaaccc tggcctgtgg atcctgggct gccacaacag cgacttcagg 360 aacaggggca tgactgccct gctgaaagtc tccagctgtg acaagaacac cggggactac 420 tacgaggaca gctacgagga catcagcgcc tacctgctga gcaagaacaa tgccatcgag 480 cccaggagct tctctcagaa ccccccagtg ctgaagaggc accagaggga gatcaccagg 540 accaccctgc agtctgacca ggaggagatc gactatgatg acaccatcag cgtggagatg 600 aagaaggagg acttcgacat ctacgacgag gacgagaacc agagccccag gagcttccag 660 aagaagacca ggcactactt cattgctgct gtggagaggc tgtgggacta tggcatgtcc 720 agcagccccc atgtgctgag gaacagggcc cagtctggca gcgtgcccca gttcaagaaa 780 gtcgtgttcc aggagttcac cgacggcagc ttcacccagc ccctgtacag aggggagctg 840 aacgagcacc tgggcctgct gggcccctac atcagggccg aggtggagga caacatcatg 900 gtgaccttca ggaaccaggc cagcaggccc tacagcttct acagcagcct gatcagctac 960 gaggaggacc agaggcaggg ggctgagccc aggaagaact ttgtgaagcc caatgaaacc 1020 aagacctact tctggaaggt gcagcaccac atggccccca ccaaggacga gttcgactgc 1080 aaggcctggg cctacttctc tgacgtggac ctggagaagg acgtgcactc tggcctgatt 1140 ggccccctgc tggtgtgcca caccaacacc ctgaaccctg cccatggcag gcaggtgact 1200 gtgcaggagt tcgccctgtt cttcaccatc ttcgatgaaa ccaagagctg gtacttcact 1260 gagaacatgg agaggaactg cagggccccc tgcaacatcc agatggagga ccccaccttc 1320 aaggagaact acaggttcca tgccatcaat ggctacatca tggacaccct gcctggcctg 1380 gtcatggccc aggaccagag gatcaggtgg tatctgctga gcatgggcag caacgagaac 1440 atccacagca tccacttctc tggccacgtg ttcactgtga ggaagaagga ggagtacaag 1500 atggccctgt acaacctgta ccctggggtg ttcgaaaccg tggagatgct gcccagcaag 1560 gccggcatct ggagggtgga gtgcctgatt ggggagcacc tgcacgccgg catgagcacc 1620 ctgttcctgg tgtacagcaa caagtgccag acccccctgg gcatggcctc tggccacatc 1680 agggacttcc agatcactgc ctctggccag tacggccagt gggcccccaa gctggccagg 1740 ctgcactact ccggaagcat caatgcctgg agcaccaagg agcccttcag ctggatcaaa 1800 gtggacctgc tggcccccat gatcatccac ggcatcaaga cccagggggc caggcagaag 1860 ttctccagcc tgtacatcag ccagttcatc atcatgtaca gcctggacgg caagaagtgg 1920 cagacctaca ggggcaacag caccggcacc ctgatggtgt tcttcggcaa cgtggacagc 1980 agcggcatca agcacaacat cttcaacccc cccatcatcg ccagatacat caggctgcac 2040 cccacccact acagcatcag gagcaccctg aggatggagc tgatgggctg tgacctgaac 2100 agctgcagca tgcccctggg catggagagc aaggccatct ctgacgccca gatcactgcc 2160 tccagctact tcaccaacat gtttgccacc tggagcccca gcaaggccag gctgcacctg 2220 cagggcagga gcaatgcctg gaggccccag gtcaacaacc ccaaggagtg gctgcaggtg 2280 gacttccaga agaccatgaa ggtgactggg gtgaccaccc agggggtgaa gagcctgctg 2340 accagcatgt acgtgaagga gttcctgatc tccagcagcc aggacggcca ccagtggacc 2400 ctgttcttcc agaatggcaa ggtgaaggtg ttccagggca accaggacag cttcacccct 2460 gtggtcaaca gcctggaccc ccccctgctg accagatacc tgaggatcca cccccagagc 2520 tgggtgcacc agatcgccct gaggatggag gtgctgggct gtgaggccca ggacctgtac 2580 tga 2583 <210> 9 <211> 1734 <212> ADN <213> Secuencia Artificial <220> <223> coFVIII-62-NT58 <400> 9 gccactcgcc ggtactacct tggagccgtg gagctttcat gggactacat gcagagcgac 60 ctgggcgaac tccccgtgga tgccagattc cccccccgcg tgccaaagtc cttccccttt 120 aacacctccg tggtgtacaa gaaaaccctc tttgtcgagt tcactgacca cctgttcaac 180 atcgccaagc cgcgcccacc ttggatgggc ctcctgggac cgaccattca agctgaagtg 240 tacgacaccg tggtgatcac cctgaagaac atggcgtccc accccgtgtc cctgcatgcg 300 gtcggagtgt cctactggaa ggcctccgaa ggagctgagt acgacgacca gactagccag 360 cgggaaaagg aggacgataa agtgttcccg ggcggctcgc atacttacgt gtggcaagtc 420 ctgaaggaaa acggacctat ggcatccgat cctctgtgcc tgacttactc ctacctttcc 480 catgtggacc tcgtgaagga cctgaacagc gggctgattg gtgcacttct cgtgtgccgc 540 gaaggttcgc tcgctaagga aaagacccag accctccata agttcatcct tttgttcgct 600 gtgttcgatg aaggaaagtc atggcattcc gaaactaaga actcgctgat gcaggaccgg 660 gatgccgcct cagcccgcgc ctggcctaaa atgcatacag tcaacggata cgtgaatcgg 720 tcactgcccg ggctcatcgg ttgtcacaga aagtccgtgt actggcacgt catcggcatg 780 ggcactacgc ctgaagtgca ctccatcttc ctggaagggc acaccttcct cgtgcgcaac 840 caccgccagg cctctctgga aatctccccg attacctttc tgaccgccca gactctgctc 900 atggacctgg ggcagttcct tctcttctgc cacatctcca gccatcagca cgacggaatg 960 gaggcctacg tgaaggtgga ctcatgcccg gaagaacctc agttgcggat gaagaacaac 1020 gaggaggccg aggactatga cgacgatttg actgactccg agatggacgt cgtgcggttc 1080 gatgacgaca acagccccag cttcatccag attcgcagcg tggccaagaa gcaccccaaa 1140 acctgggtgc actacatcgc ggccgaggaa gaagattggg actacgcccc gttggtgctg 1200 gcacccgatg accggtcgta caagtcccag tatctgaaca atggtccgca gcggattggc 1260 agaaagtaca agaaagtgcg gttcatggcg tacactgacg aaacgtttaa gacccgggag 1320 gccattcaac atgagagcgg cattctggga ccactgctgt acggagaggt cggcgatacc 1380 ctgctcatca tcttcaaaaa ccaggcctcc cggccttaca acatctaccc tcacggaatc 1440 accgacgtgc ggccactcta ctcgcggcgc ctgccgaagg gcgtcaagca cctgaaagac 1500 ttccctatcc tgccgggcga aatcttcaag tataagtgga ccgtcaccgt ggaggacggg 1560 cccaccaaga gcgatcctag gtgtctgact cggtactact ccagcttcgt gaacatggaa 1620 cgggacctgg catcgggact cattggaccg ctgctgatct gctacaaaga gtcggtggat 1680 caacgcggca accagatcat gtccgacaag cgcaacgtga tcctgttctc cgtg 1734 <210> 10 <211> 2583 <212> ADN <213> Secuencia Artificial <220> <223> coFVIII-62-CT <400> 10 tttgatgaaa acagatcctg gtacctgacc gagaacatcc agaggttcct gcccaaccct 60 gctggggtgc agctggagga ccccgagttc caggccagca acatcatgca cagcatcaat 120 ggctacgtgt tcgacagcct gcagctgagc gtgtgcctgc acgaggtggc ctactggtac 180 atcctgagca tcggcgccca gaccgacttc ctgagcgtgt tcttctctgg ctacaccttc 240 aagcacaaga tggtgtatga ggacaccctg accctgttcc ccttcagcgg ggagactgtc 300 ttcatgagca tggagaaccc tggcctgtgg atcctgggct gccacaacag cgacttcagg 360 aacaggggca tgactgccct gctgaaagtc tccagctgtg acaagaacac cggggactac 420 tacgaggaca gctacgagga catcagcgcc tacctgctga gcaagaacaa tgccatcgag 480 cccaggagct tctctcagaa ccccccagtg ctgaagaggc accagaggga gatcaccagg 540 accaccctgc agtctgacca ggaggagatc gactatgatg acaccatcag cgtggagatg 600 aagaaggagg acttcgacat ctacgacgag gacgagaacc agagccccag gagcttccag 660 aagaagacca ggcactactt cattgctgct gtggagaggc tgtgggacta tggcatgtcc 720 agcagccccc atgtgctgag gaacagggcc cagtctggca gcgtgcccca gttcaagaaa 780 gtcgtgttcc aggagttcac cgacggcagc ttcacccagc ccctgtacag aggggagctg 840 aacgagcacc tgggcctgct gggcccctac atcagggccg aggtggagga caacatcatg 900 gtgaccttca ggaaccaggc cagcaggccc tacagcttct acagcagcct gatcagctac 960 gaggaggacc agaggcaggg ggctgagccc aggaagaact ttgtgaagcc caatgaaacc 1020 aagacctact tctggaaggt gcagcaccac atggccccca ccaaggacga gttcgactgc 1080 aaggcctggg cctacttctc tgacgtggac ctggagaagg acgtgcactc tggcctgatt 1140 ggccccctgc tggtgtgcca caccaacacc ctgaaccctg cccatggcag gcaggtgact 1200 gtgcaggagt tcgccctgtt cttcaccatc ttcgatgaaa ccaagagctg gtacttcact 1260 gagaacatgg agaggaactg cagggccccc tgcaacatcc agatggagga ccccaccttc 1320 aaggagaact acaggttcca tgccatcaat ggctacatca tggacaccct gcctggcctg 1380 gtcatggccc aggaccagag gatcaggtgg tatctgctga gcatgggcag caacgagaac 1440 atccacagca tccacttctc tggccacgtg ttcactgtga ggaagaagga ggagtacaag 1500 atggccctgt acaacctgta ccctggggtg ttcgaaaccg tggagatgct gcccagcaag 1560 gccggcatct ggagggtgga gtgcctgatt ggggagcacc tgcacgccgg catgagcacc 1620 ctgttcctgg tgtacagcaa caagtgccag acccccctgg gcatggcctc tggccacatc 1680 agggacttcc agatcactgc ctctggccag tacggccagt gggcccccaa gctggccagg 1740 ctgcactact ccggaagcat caatgcctgg agcaccaagg agcccttcag ctggatcaaa 1800 gtggacctgc tggcccccat gatcatccac ggcatcaaga cccagggggc caggcagaag 1860 ttctccagcc tgtacatcag ccagttcatc atcatgtaca gcctggacgg caagaagtgg 1920 cagacctaca ggggcaacag caccggcacc ctgatggtgt tcttcggcaa cgtggacagc 1980 agcggcatca agcacaacat cttcaacccc cccatcatcg ccagatacat caggctgcac 2040 cccacccact acagcatcag gagcaccctg aggatggagc tgatgggctg tgacctgaac 2100 agctgcagca tgcccctggg catggagagc aaggccatct ctgacgccca gatcactgcc 2160 tccagctact tcaccaacat gtttgccacc tggagcccca gcaaggccag gctgcacctg 2220 cagggcagga gcaatgcctg gaggccccag gtcaacaacc ccaaggagtg gctgcaggtg 2280 gacttccaga agaccatgaa ggtgactggg gtgaccaccc agggggtgaa gagcctgctg 2340 accagcatgt acgtgaagga gttcctgatc tccagcagcc aggacggcca ccagtggacc 2400 ctgttcttcc agaatggcaa ggtgaaggtg ttccagggca accaggacag cttcacccct 2460 gtggtcaaca gcctggaccc ccccctgctg accagatacc tgaggatcca cccccagagc 2520 tgggtgcacc agatcgccct gaggatggag gtgctgggct gtgaggccca ggacctgtac 2580 tga 2583 <210> 11 <211> 1734 <212> ADN <213> Secuencia Artificial <220> <223> coFVIII-25-NT58 <400> 11 gccaccagga gatactacct gggcgccgtg gagctgagct gggactacat gcagtctgac 60 ctgggcgagc tgccagtgga cgccaggttc ccccccagag tgcccaagag cttccccttc 120 aacaccagcg tggtgtacaa gaagaccctg ttcgtggagt tcactgacca cctgttcaac 180 atcgccaagc ccaggccccc ctggatgggc ctgctgggcc ccaccatcca ggccgaggtg 240 tacgacaccg tggtcatcac cctgaagaac atggccagcc accccgtctc cctgcacgcc 300 gtgggggtga gctactggaa ggcctctgag ggcgccgagt acgacgacca gaccagccag 360 agggagaagg aggacgacaa ggtgttccct gggggcagcc acacctacgt gtggcaggtc 420 ctgaaggaga acggccccat ggcctctgac cccctgtgcc tgacctacag ctacctgagc 480 cacgtggacc tggtgaagga cctgaactct ggcctgattg gggccctgct ggtgtgcagg 540 gagggcagcc tggccaagga gaagacccag accctgcaca agttcatcct gctgttcgcc 600 gtgttcgacg agggcaagag ctggcactct gaaaccaaga acagcctgat gcaggacagg 660 gacgccgcct ctgccagggc ctggcccaag atgcacaccg tcaacggcta cgtcaacagg 720 agcctgcctg gcctgattgg ctgccacagg aagagcgtgt actggcatgt gatcggcatg 780 ggcaccaccc ctgaggtgca cagcatcttc ctggagggcc acaccttcct ggtcaggaac 840 cacaggcagg ccagcctgga gatcagcccc atcaccttcc tgaccgccca gaccctgctg 900 atggacctgg gccagttcct gctgttctgc cacatctcca gccaccagca cgacggcatg 960 gaggcctacg tgaaagtgga cagctgccct gaggagcccc agctgaggat gaagaacaac 1020 gaggaggccg aggactatga tgacgacctg accgacagcg agatggacgt ggtcaggttc 1080 gacgacgaca acagccccag cttcatccag atcaggagcg tggccaagaa gcaccccaag 1140 acctgggtgc actacatcgc tgctgaggag gaggactggg actatgcccc cctggtgctg 1200 gcccctgatg acaggagcta caagagccag tacctgaaca atggccccca gaggattggc 1260 aggaagtaca agaaagtcag gttcatggcc tacactgatg aaaccttcaa gaccagggag 1320 gccatccagc atgagtctgg catcctgggc cccctgctgt acggggaggt gggggacacc 1380 ctgctgatca tcttcaagaa ccaggccagc aggccctaca acatctaccc ccatggcatc 1440 accgacgtga ggcccctgta cagcaggagg ctgcctaagg gggtgaagca cctgaaagac 1500 ttccccatcc tgcctgggga gatcttcaag tacaagtgga ctgtgactgt ggaggacggc 1560 cccaccaaga gcgaccccag gtgcctgacc agatactaca gcagcttcgt caacatggag 1620 agggacctgg cctctggcct gattggcccc ctgctgatct gctacaagga gtctgtggac 1680 cagaggggca accagatcat gagcgacaag aggaacgtga tcctgttctc tgtc 1734 <210> 12 <211> 2583 <212> ADN <213> Secuencia Artificial <220> <223> coFVIII-25-CT <400> 12 ttcgacgaga acaggagctg gtacctgact gaaaacatcc agcggttcct ccccaacccc 60 gcgggcgtgc agctggaaga tcctgagttt caggcatcaa acatcatgca ctccattaac 120 ggctacgtgt tcgattcgct gcagctgagc gtgtgtctgc acgaagtggc ctactggtac 180 atcctgtcca ttggtgccca gactgacttc ctgtccgtgt ttttctccgg ctacacgttc 240 aagcacaaga tggtgtacga ggacaccctg accctcttcc ctttttccgg cgaaactgtg 300 tttatgagca tggagaatcc cggcctgtgg atcttgggct gccacaacag cgacttccgt 360 aacagaggaa tgactgcgct gctcaaggtg tccagctgcg acaagaacac cggagactat 420 tatgaggact catacgagga catctccgcc tacctcctgt ccaagaataa cgccattgaa 480 cctcggagct tcagccagaa cccacccgtg cttaagagac atcaacggga gatcactagg 540 accaccctgc agtcagacca ggaggaaatc gactacgatg acaccatctc ggtcgagatg 600 aagaaggagg actttgacat ctacgacgaa gatgaaaacc agagcccgag gtcgttccaa 660 aagaaaaccc gccactactt tattgctgct gtcgagcggc tgtgggacta cggaatgtcg 720 tcctcgccgc acgtgctccg caaccgagcc cagagcggct cggtgccgca attcaagaag 780 gtcgtgttcc aggagttcac tgacgggagc ttcactcagc ctttgtaccg gggagaactc 840 aatgaacatc tcggcctcct cggaccttac atcagagcag aagtggaaga taacatcatg 900 gtcactttcc gtaaccaagc cagccgcccg tactcgttct actcctccct catttcttac 960 gaagaggacc agcggcaggg cgcagaaccg cgcaagaact tcgtgaagcc caacgaaacc 1020 aagacctact tctggaaagt gcagcatcat atggccccga ctaaggacga gtttgactgc 1080 aaagcctggg cctacttctc cgatgtggac ttggagaagg acgtccactc cggcctcatc 1140 ggtcccctgc tcgtgtgcca taccaatacc ctgaaccccg cacacggtcg ccaggtcacc 1200 gtgcaggagt tcgctctgtt cttcactatc ttcgacgaaa ctaagtcctg gtacttcacc 1260 gagaacatgg agaggaactg cagagccccc tgtaacatcc agatggagga cccgacgttc 1320 aaggaaaact accggttcca cgccattaac ggatacatca tggatacgct gccgggtctt 1380 gtgatggccc aggatcaacg gatcagatgg tacttattgt cgatgggcag caacgagaac 1440 atccactcta ttcacttctc cggtcatgtg ttcactgtgc ggaagaagga agagtacaag 1500 atggccctgt acaaccttta tcccggagtg ttcgaaactg tggaaatgct gccgtcgaag 1560 gccggcattt ggcgcgtgga gtgtttgatt ggagaacatc tccatgcggg gatgtcaacc 1620 ctgttcctgg tgtatagcaa caagtgccag actccgcttg ggatggcgtc aggacacatt 1680 agggatttcc agatcactgc gtccggccag tacggccaat gggcccctaa gctggcccgc 1740 ctgcattact ccggatccat taacgcctgg tcaaccaagg agccattctc ctggatcaag 1800 gtggaccttc tggcccccat gattatccac ggaattaaga cccagggggc ccggcagaag 1860 ttctcctcac tgtacatcag ccagttcata atcatgtact ccctggacgg aaagaagtgg 1920 caaacctaca gggggaacag caccggcaca ctgatggtct ttttcggaaa tgtggactcc 1980 tccgggatta agcataacat cttcaaccct ccgattatcg ctcggtacat tagacttcac 2040 cctacccact acagcattcg ctccaccctg cggatggaac tgatgggctg cgatctgaac 2100 tcgtgcagca tgccgttggg aatggagtcc aaagcaattt ccgacgcgca gatcaccgcc 2160 tcgtcctact ttaccaacat gttcgccacg tggtcaccgt ccaaggcccg gctgcacctc 2220 cagggaagat ccaacgcatg gcggccacag gtcaacaacc ctaaggagtg gctccaggtg 2280 gacttccaga aaaccatgaa ggtcaccgga gtcacaaccc agggagtgaa gtcgctgctg 2340 acttctatgt acgtcaagga gttcctgatc tccagcagcc aggacgggca ccagtggacc 2400 ctgttcttcc aaaatggaaa ggtcaaggtg tttcagggca atcaggattc attcaccccg 2460 gtggtgaact cccttgatcc acccctcctg acccgctacc ttcgcatcca cccacagtcc 2520 tgggtgcacc agatcgcgct gaggatggag gtcctgggat gcgaagccca ggacctgtac 2580 tga 2583 <210> 13 <211> 1734 <212> ADN <213> Secuencia Artificial <220> <223> coFVIII-26-NT58 <400> 13 gccaccagga gatactacct gggcgccgtg gagctgagct gggactacat gcagtctgac 60 ctgggcgagc tgccagtgga cgccaggttc ccccccagag tgcccaagag cttccccttc 120 aacaccagcg tggtgtacaa gaagaccctg ttcgtggagt tcactgacca cctgttcaac 180 atcgccaagc ccaggccccc ctggatgggc ctgctgggcc ccaccatcca ggccgaggtg 240 tacgacaccg tggtcatcac cctgaagaac atggccagcc accccgtctc cctgcacgcc 300 gtgggggtga gctactggaa ggcctctgag ggcgccgagt acgacgacca gaccagccag 360 agggagaagg aggacgacaa ggtgttccct gggggcagcc acacctacgt gtggcaggtc 420 ctgaaggaga acggccccat ggcctctgac cccctgtgcc tgacctacag ctacctgagc 480 cacgtggacc tggtgaagga cctgaactct ggcctgattg gggccctgct ggtgtgcagg 540 gagggcagcc tggccaagga gaagacccag accctgcaca agttcatcct gctgttcgcc 600 gtgttcgacg agggcaagag ctggcactct gaaaccaaga acagcctgat gcaggacagg 660 gacgccgcct ctgccagggc ctggcccaag atgcacaccg tcaacggcta cgtcaacagg 720 agcctgcctg gcctgattgg ctgccacagg aagagcgtgt actggcatgt gatcggcatg 780 ggcaccaccc ctgaggtgca cagcatcttc ctggagggcc acaccttcct ggtcaggaac 840 cacaggcagg ccagcctgga gatcagcccc atcaccttcc tgaccgccca gaccctgctg 900 atggacctgg gccagttcct gctgttctgc cacatctcca gccaccagca cgacggcatg 960 gaggcctacg tgaaagtgga cagctgccct gaggagcccc agctgaggat gaagaacaac 1020 gaggaggccg aggactatga tgacgacctg accgacagcg agatggacgt ggtcaggttc 1080 gacgacgaca acagccccag cttcatccag atcaggagcg tggccaagaa gcaccccaag 1140 acctgggtgc actacatcgc tgctgaggag gaggactggg actatgcccc cctggtgctg 1200 gcccctgatg acaggagcta caagagccag tacctgaaca atggccccca gaggattggc 1260 aggaagtaca agaaagtcag gttcatggcc tacactgatg aaaccttcaa gaccagggag 1320 gccatccagc atgagtctgg catcctgggc cccctgctgt acggggaggt gggggacacc 1380 ctgctgatca tcttcaagaa ccaggccagc aggccctaca acatctaccc ccatggcatc 1440 accgacgtga ggcccctgta cagcaggagg ctgcctaagg gggtgaagca cctgaaagac 1500 ttccccatcc tgcctgggga gatcttcaag tacaagtgga ctgtgactgt ggaggacggc 1560 cccaccaaga gcgaccccag gtgcctgacc agatactaca gcagcttcgt caacatggag 1620 agggacctgg cctctggcct gattggcccc ctgctgatct gctacaagga gtctgtggac 1680 cagaggggca accagatcat gagcgacaag aggaacgtga tcctgttctc tgtc 1734 <210> 14 <211> 2583 <212> ADN <213> Secuencia Artificial <220> <223> coFVIII-26-CT <400> 14 ttcgacgaga acaggagctg gtacctcact gaaaacatcc agaggttcct cccaaacccc 60 gcaggagtgc aactggagga ccctgagttt caggcctcga atatcatgca ctcgattaac 120 ggttacgtgt tcgactcgct gcagctgagc gtgtgcctcc atgaagtcgc ttactggtac 180 attctgtcca tcggcgccca gactgacttc ctgagcgtgt tcttttccgg ttacaccttt 240 aagcacaaga tggtgtacga agataccctg accctgttcc ctttctccgg cgaaacggtg 300 ttcatgtcga tggagaaccc gggtctgtgg attctgggat gccacaacag cgactttcgg 360 aaccgcggaa tgactgccct gctgaaggtg tcctcatgcg acaagaacac cggagactac 420 tacgaggact cctacgagga tatctcagcc tacctcctgt ccaagaacaa cgcgatcgag 480 ccgcgcagct tcagccagaa cccgcctgtg ctgaagaggc accagcgaga aattacccgg 540 accaccctcc aatcggatca ggaggaaatc gactacgacg acaccatctc ggtggaaatg 600 aagaaggaag atttcgatat ctacgacgag gacgaaaatc agtcccctcg ctcattccaa 660 aagaaaacta gacactactt tatcgccgcg gtggaaagac tgtgggacta tggaatgtca 720 tccagccctc acgtccttcg gaaccgggcc cagagcggat cggtgcctca gttcaagaaa 780 gtggtgttcc aggagttcac cgacggcagc ttcacccagc cgctgtaccg gggagaactg 840 aacgaacacc tgggcctgct cggtccctac atccgcgcgg aagtggagga taacatcatg 900 gtgaccttcc gtaaccaagc atccagacct tactccttct attcctccct gatctcatac 960 gaggaggacc agcgccaagg cgccgagccc cgcaagaact tcgtcaagcc caacgagact 1020 aagacctact tctggaaggt ccaacaccat atggccccga ccaaggatga gtttgactgc 1080 aaggcctggg cctacttctc cgacgtggac cttgagaagg atgtccattc cggcctgatc 1140 gggccgctgc tcgtgtgtca caccaacacc ctgaacccag cgcatggacg ccaggtcacc 1200 gtccaggagt ttgctctgtt cttcaccatt tttgacgaaa ctaagtcctg gtacttcacc 1260 gagaatatgg agcgaaactg tagagcgccc tgcaatatcc agatggaaga tccgactttc 1320 aaggagaact atagattcca cgccatcaac gggtacatca tggatactct gccggggctg 1380 gtcatggccc aggatcagag gattcggtgg tacttgctgt caatgggatc gaacgaaaac 1440 attcactcca ttcacttctc cggtcacgtg ttcactgtgc gcaagaagga ggagtacaag 1500 atggcgctgt acaatctgta ccccggggtg ttcgaaactg tggagatgct gccgtccaag 1560 gccggcatct ggagagtgga gtgcctgatc ggagagcacc tccacgcggg gatgtccacc 1620 ctcttcctgg tgtactcgaa taagtgccag accccgctgg gcatggcctc gggccacatc 1680 agagacttcc agatcacagc aagcggacaa tacggccaat gggcgccgaa gctggcccgc 1740 ttgcactact ccggatcgat caacgcatgg tccaccaagg aaccgttctc gtggattaag 1800 gtggacctcc tggcccctat gattatccac ggaattaaga cccagggcgc caggcagaag 1860 ttctcctccc tgtacatctc gcaattcatc atcatgtaca gcctggacgg gaagaagtgg 1920 cagacttaca ggggaaactc caccggcacc ctgatggtct ttttcggcaa cgtggattcc 1980 tccggcatta agcacaacat cttcaaccca ccgatcatag ccagatatat taggctccac 2040 cccactcact actcaatccg ctcaactctt cggatggaac tcatggggtg cgacctgaac 2100 tcctgctcca tgccgttggg gatggaatca aaggctatta gcgacgccca gatcaccgcg 2160 agctcctact tcactaacat gttcgccacc tggagcccct ccaaggccag gctgcacttg 2220 cagggacggt caaatgcctg gcggccgcaa gtgaacaatc cgaaggaatg gcttcaagtg 2280 gatttccaaa agaccatgaa agtgaccgga gtcaccaccc agggagtgaa gtcccttctg 2340 acctcgatgt atgtgaagga gttcctgatt agcagcagcc aggacgggca ccagtggacc 2400 ctgttcttcc aaaacggaaa ggtcaaggtg ttccagggga accaggactc gttcacaccc 2460 gtggtgaact ccctggaccc cccactgctg acgcggtact tgaggattca tcctcagtcc 2520 tgggtccatc agattgcatt gcgaatggaa gtcctgggct gcgaggccca ggacctgtac 2580 tga 2583 <210> 15 <211> 2332 <212> PRT <213> Homo sapiens <400> 15 Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 1 5 10 15 Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 20 25 30 Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 35 40 45 Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 50 55 60 Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 65 70 75 80 Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 85 90 95 Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 100 105 110 Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 115 120 125 Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 130 135 140 Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 145 150 155 160 His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 165 170 175 Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 180 185 190 His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 195 200 205 His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 210 215 220 Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 225 230 235 240 Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 245 250 255 Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 260 265 270 Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 275 280 285 Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 290 295 300 Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 305 310 315 320 Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 325 330 335 Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 340 345 350 Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 355 360 365 Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 370 375 380 Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 385 390 395 400 Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 405 410 415 Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 420 425 430 Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 435 440 445 Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 450 455 460 Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 465 470 475 480 Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 485 490 495 His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 500 505 510 Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 515 520 525 Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 530 535 540 Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 545 550 555 560 Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 565 570 575 Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 580 585 590 Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 595 600 605 Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 610 615 620 Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 625 630 635 640 Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 645 650 655 Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 660 665 670 Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 675 680 685 Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 690 695 700 Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 705 710 715 720 Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 725 730 735 Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg 740 745 750 Gln Lys Gln Phe Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys 755 760 765 Thr Asp Pro Trp Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn 770 775 780 Val Ser Ser Ser Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro 785 790 795 800 His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe 805 810 815 Ser Asp Asp Pro Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser 820 825 830 Glu Met Thr His Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val 835 840 845 Phe Thr Pro Glu Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly 850 855 860 Thr Thr Ala Ala Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser 865 870 875 880 Thr Ser Asn Asn Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala 885 890 895 Gly Thr Asp Asn Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His 900 905 910 Tyr Asp Ser Gln Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro 915 920 925 Leu Thr Glu Ser Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp 930 935 940 Ser Lys Leu Leu Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp 945 950 955 960 Gly Lys Asn Val Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys 965 970 975 Arg Ala His Gly Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys 980 985 990 Val Ser Ile Ser Leu Leu Lys Thr Asn Lys Thr Ser Asn Asn Ser Ala 995 1000 1005 Thr Asn Arg Lys Thr His Ile Asp Gly Pro Ser Leu Leu Ile Glu 1010 1015 1020 Asn Ser Pro Ser Val Trp Gln Asn Ile Leu Glu Ser Asp Thr Glu 1025 1030 1035 Phe Lys Lys Val Thr Pro Leu Ile His Asp Arg Met Leu Met Asp 1040 1045 1050 Lys Asn Ala Thr Ala Leu Arg Leu Asn His Met Ser Asn Lys Thr 1055 1060 1065 Thr Ser Ser Lys Asn Met Glu Met Val Gln Gln Lys Lys Glu Gly 1070 1075 1080 Pro Ile Pro Pro Asp Ala Gln Asn Pro Asp Met Ser Phe Phe Lys 1085 1090 1095 Met Leu Phe Leu Pro Glu Ser Ala Arg Trp Ile Gln Arg Thr His 1100 1105 1110 Gly Lys Asn Ser Leu Asn Ser Gly Gln Gly Pro Ser Pro Lys Gln 1115 1120 1125 Leu Val Ser Leu Gly Pro Glu Lys Ser Val Glu Gly Gln Asn Phe 1130 1135 1140 Leu Ser Glu Lys Asn Lys Val Val Val Gly Lys Gly Glu Phe Thr 1145 1150 1155 Lys Asp Val Gly Leu Lys Glu Met Val Phe Pro Ser Ser Arg Asn 1160 1165 1170 Leu Phe Leu Thr Asn Leu Asp Asn Leu His Glu Asn Asn Thr His 1175 1180 1185 Asn Gln Glu Lys Lys Ile Gln Glu Glu Ile Glu Lys Lys Glu Thr 1190 1195 1200 Leu Ile Gln Glu Asn Val Val Leu Pro Gln Ile His Thr Val Thr 1205 1210 1215 Gly Thr Lys Asn Phe Met Lys Asn Leu Phe Leu Leu Ser Thr Arg 1220 1225 1230 Gln Asn Val Glu Gly Ser Tyr Asp Gly Ala Tyr Ala Pro Val Leu 1235 1240 1245 Gln Asp Phe Arg Ser Leu Asn Asp Ser Thr Asn Arg Thr Lys Lys 1250 1255 1260 His Thr Ala His Phe Ser Lys Lys Gly Glu Glu Glu Asn Leu Glu 1265 1270 1275 Gly Leu Gly Asn Gln Thr Lys Gln Ile Val Glu Lys Tyr Ala Cys 1280 1285 1290 Thr Thr Arg Ile Ser Pro Asn Thr Ser Gln Gln Asn Phe Val Thr 1295 1300 1305 Gln Arg Ser Lys Arg Ala Leu Lys Gln Phe Arg Leu Pro Leu Glu 1310 1315 1320 Glu Thr Glu Leu Glu Lys Arg Ile Ile Val Asp Asp Thr Ser Thr 1325 1330 1335 Gln Trp Ser Lys Asn Met Lys His Leu Thr Pro Ser Thr Leu Thr 1340 1345 1350 Gln Ile Asp Tyr Asn Glu Lys Glu Lys Gly Ala Ile Thr Gln Ser 1355 1360 1365 Pro Leu Ser Asp Cys Leu Thr Arg Ser His Ser Ile Pro Gln Ala 1370 1375 1380 Asn Arg Ser Pro Leu Pro Ile Ala Lys Val Ser Ser Phe Pro Ser 1385 1390 1395 Ile Arg Pro Ile Tyr Leu Thr Arg Val Leu Phe Gln Asp Asn Ser 1400 1405 1410 Ser His Leu Pro Ala Ala Ser Tyr Arg Lys Lys Asp Ser Gly Val 1415 1420 1425 Gln Glu Ser Ser His Phe Leu Gln Gly Ala Lys Lys Asn Asn Leu 1430 1435 1440 Ser Leu Ala Ile Leu Thr Leu Glu Met Thr Gly Asp Gln Arg Glu 1445 1450 1455 Val Gly Ser Leu Gly Thr Ser Ala Thr Asn Ser Val Thr Tyr Lys 1460 1465 1470 Lys Val Glu Asn Thr Val Leu Pro Lys Pro Asp Leu Pro Lys Thr 1475 1480 1485 Ser Gly Lys Val Glu Leu Leu Pro Lys Val His Ile Tyr Gln Lys 1490 1495 1500 Asp Leu Phe Pro Thr Glu Thr Ser Asn Gly Ser Pro Gly His Leu 1505 1510 1515 Asp Leu Val Glu Gly Ser Leu Leu Gln Gly Thr Glu Gly Ala Ile 1520 1525 1530 Lys Trp Asn Glu Ala Asn Arg Pro Gly Lys Val Pro Phe Leu Arg 1535 1540 1545 Val Ala Thr Glu Ser Ser Ala Lys Thr Pro Ser Lys Leu Leu Asp 1550 1555 1560 Pro Leu Ala Trp Asp Asn His Tyr Gly Thr Gln Ile Pro Lys Glu 1565 1570 1575 Glu Trp Lys Ser Gln Glu Lys Ser Pro Glu Lys Thr Ala Phe Lys 1580 1585 1590 Lys Lys Asp Thr Ile Leu Ser Leu Asn Ala Cys Glu Ser Asn His 1595 1600 1605 Ala Ile Ala Ala Ile Asn Glu Gly Gln Asn Lys Pro Glu Ile Glu 1610 1615 1620 Val Thr Trp Ala Lys Gln Gly Arg Thr Glu Arg Leu Cys Ser Gln 1625 1630 1635 Asn Pro Pro Val Leu Lys Arg His Gln Arg Glu Ile Thr Arg Thr 1640 1645 1650 Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp Asp Thr Ile 1655 1660 1665 Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp Glu Asp 1670 1675 1680 Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr 1685 1690 1695 Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser 1700 1705 1710 Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val Pro 1715 1720 1725 Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe 1730 1735 1740 Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu 1745 1750 1755 Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val 1760 1765 1770 Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser 1775 1780 1785 Leu Ile Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg 1790 1795 1800 Lys Asn Phe Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys 1805 1810 1815 Val Gln His His Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys 1820 1825 1830 Ala Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys Asp Val His 1835 1840 1845 Ser Gly Leu Ile Gly Pro Leu Leu Val Cys His Thr Asn Thr Leu 1850 1855 1860 Asn Pro Ala His Gly Arg Gln Val Thr Val Gln Glu Phe Ala Leu 1865 1870 1875 Phe Phe Thr Ile Phe Asp Glu Thr Lys Ser Trp Tyr Phe Thr Glu 1880 1885 1890 Asn Met Glu Arg Asn Cys Arg Ala Pro Cys Asn Ile Gln Met Glu 1895 1900 1905 Asp Pro Thr Phe Lys Glu Asn Tyr Arg Phe His Ala Ile Asn Gly 1910 1915 1920 Tyr Ile Met Asp Thr Leu Pro Gly Leu Val Met Ala Gln Asp Gln 1925 1930 1935 Arg Ile Arg Trp Tyr Leu Leu Ser Met Gly Ser Asn Glu Asn Ile 1940 1945 1950 His Ser Ile His Phe Ser Gly His Val Phe Thr Val Arg Lys Lys 1955 1960 1965 Glu Glu Tyr Lys Met Ala Leu Tyr Asn Leu Tyr Pro Gly Val Phe 1970 1975 1980 Glu Thr Val Glu Met Leu Pro Ser Lys Ala Gly Ile Trp Arg Val 1985 1990 1995 Glu Cys Leu Ile Gly Glu His Leu His Ala Gly Met Ser Thr Leu 2000 2005 2010 Phe Leu Val Tyr Ser Asn Lys Cys Gln Thr Pro Leu Gly Met Ala 2015 2020 2025 Ser Gly His Ile Arg Asp Phe Gln Ile Thr Ala Ser Gly Gln Tyr 2030 2035 2040 Gly Gln Trp Ala Pro Lys Leu Ala Arg Leu His Tyr Ser Gly Ser 2045 2050 2055 Ile Asn Ala Trp Ser Thr Lys Glu Pro Phe Ser Trp Ile Lys Val 2060 2065 2070 Asp Leu Leu Ala Pro Met Ile Ile His Gly Ile Lys Thr Gln Gly 2075 2080 2085 Ala Arg Gln Lys Phe Ser Ser Leu Tyr Ile Ser Gln Phe Ile Ile 2090 2095 2100 Met Tyr Ser Leu Asp Gly Lys Lys Trp Gln Thr Tyr Arg Gly Asn 2105 2110 2115 Ser Thr Gly Thr Leu Met Val Phe Phe Gly Asn Val Asp Ser Ser 2120 2125 2130 Gly Ile Lys His Asn Ile Phe Asn Pro Pro Ile Ile Ala Arg Tyr 2135 2140 2145 Ile Arg Leu His Pro Thr His Tyr Ser Ile Arg Ser Thr Leu Arg 2150 2155 2160 Met Glu Leu Met Gly Cys Asp Leu Asn Ser Cys Ser Met Pro Leu 2165 2170 2175 Gly Met Glu Ser Lys Ala Ile Ser Asp Ala Gln Ile Thr Ala Ser 2180 2185 2190 Ser Tyr Phe Thr Asn Met Phe Ala Thr Trp Ser Pro Ser Lys Ala 2195 2200 2205 Arg Leu His Leu Gln Gly Arg Ser Asn Ala Trp Arg Pro Gln Val 2210 2215 2220 Asn Asn Pro Lys Glu Trp Leu Gln Val Asp Phe Gln Lys Thr Met 2225 2230 2235 Lys Val Thr Gly Val Thr Thr Gln Gly Val Lys Ser Leu Leu Thr 2240 2245 2250 Ser Met Tyr Val Lys Glu Phe Leu Ile Ser Ser Ser Gln Asp Gly 2255 2260 2265 His Gln Trp Thr Leu Phe Phe Gln Asn Gly Lys Val Lys Val Phe 2270 2275 2280 Gln Gly Asn Gln Asp Ser Phe Thr Pro Val Val Asn Ser Leu Asp 2285 2290 2295 Pro Pro Leu Leu Thr Arg Tyr Leu Arg Ile His Pro Gln Ser Trp 2300 2305 2310 Val His Gln Ile Ala Leu Arg Met Glu Val Leu Gly Cys Glu Ala 2315 2320 2325 Gln Asp Leu Tyr 2330 <210> 16 <211> 4371 <212> ADN <213> Secuencia Artificial <220> <223> FVIII BDD (no optimizado; "parental"), Secuencia de Nucleótidos <400> 16 atgcaaatag agctctccac ctgcttcttt ctgtgccttt tgcgattctg ctttagtgcc 60 accagaagat actacctggg tgcagtggaa ctgtcatggg actatatgca aagtgatctc 120 ggtgagctgc ctgtggacgc aagatttcct cctagagtgc caaaatcttt tccattcaac 180 acctcagtcg tgtacaaaaa gactctgttt gtagaattca cggatcacct tttcaacatc 240 gctaagccaa ggccaccctg gatgggtctg ctaggtccta ccatccaggc tgaggtttat 300 gatacagtgg tcattacact taagaacatg gcttcccatc ctgtcagtct tcatgctgtt 360 ggtgtatcct actggaaagc ttctgaggga gctgaatatg atgatcagac cagtcaaagg 420 gagaaagaag atgataaagt cttccctggt ggaagccata catatgtctg gcaggtcctg 480 aaagagaatg gtccaatggc ctctgaccca ctgtgcctta cctactcata tctttctcat 540 gtggacctgg taaaagactt gaattcaggc ctcattggag ccctactagt atgtagagaa 600 gggagtctgg ccaaggaaaa gacacagacc ttgcacaaat ttatactact ttttgctgta 660 tttgatgaag ggaaaagttg gcactcagaa acaaagaact ccttgatgca ggatagggat 720 gctgcatctg ctcgggcctg gcctaaaatg cacacagtca atggttatgt aaacaggtct 780 ctgccaggtc tgattggatg ccacaggaaa tcagtctatt ggcatgtgat tggaatgggc 840 accactcctg aagtgcactc aatattcctc gaaggtcaca catttcttgt gaggaaccat 900 cgccaggcgt ccttggaaat ctcgccaata actttcctta ctgctcaaac actcttgatg 960 gaccttggac agtttctact gttttgtcat atctcttccc accaacatga tggcatggaa 1020 gcttatgtca aagtagacag ctgtccagag gaaccccaac tacgaatgaa aaataatgaa 1080 gaagcggaag actatgatga tgatcttact gattctgaaa tggatgtggt caggtttgat 1140 gatgacaact ctccttcctt tatccaaatt cgctcagttg ccaagaagca tcctaaaact 1200 tgggtacatt acattgctgc tgaagaggag gactgggact atgctccctt agtcctcgcc 1260 cccgatgaca gaagttataa aagtcaatat ttgaacaatg gccctcagcg gattggtagg 1320 aagtacaaaa aagtccgatt tatggcatac acagatgaaa cctttaagac tcgtgaagct 1380 attcagcatg aatcaggaat cttgggacct ttactttatg gggaagttgg agacacactg 1440 ttgattatat ttaagaatca agcaagcaga ccatataaca tctaccctca cggaatcact 1500 gatgtccgtc ctttgtattc aaggagatta ccaaaaggtg taaaacattt gaaggatttt 1560 ccaattctgc caggagaaat attcaaatat aaatggacag tgactgtaga agatgggcca 1620 actaaatcag atcctcggtg cctgacccgc tattactcta gtttcgttaa tatggagaga 1680 gatctagctt caggactcat tggccctctc ctcatctgct acaaagaatc tgtagatcaa 1740 agaggaaacc agataatgtc agacaagagg aatgtcatcc tgttttctgt atttgatgag 1800 aaccgaagct ggtacctcac agagaatata caacgctttc tccccaatcc agctggagtg 1860 cagcttgagg atccagagtt ccaagcctcc aacatcatgc acagcatcaa tggctatgtt 1920 tttgatagtt tgcagttgtc agtttgtttg catgaggtgg catactggta cattctaagc 1980 attggagcac agactgactt cctttctgtc ttcttctctg gatatacctt caaacacaaa 2040 atggtctatg aagacacact caccctattc ccattctcag gagaaactgt cttcatgtcg 2100 atggaaaacc caggtctatg gattctgggg tgccacaact cagactttcg gaacagaggc 2160 atgaccgcct tactgaaggt ttctagttgt gacaagaaca ctggtgatta ttacgaggac 2220 agttatgaag atatttcagc atacttgctg agtaaaaaca atgccattga accaagaagc 2280 ttctctcaaa acccaccagt cttgaaacgc catcaacggg aaataactcg tactactctt 2340 cagtcagatc aagaggaaat tgactatgat gataccatat cagttgaaat gaagaaggaa 2400 gattttgaca tttatgatga ggatgaaaat cagagccccc gcagctttca aaagaaaaca 2460 cgacactatt ttattgctgc agtggagagg ctctgggatt atgggatgag tagctcccca 2520 catgttctaa gaaacagggc tcagagtggc agtgtccctc agttcaagaa agttgttttc 2580 caggaattta ctgatggctc ctttactcag cccttatacc gtggagaact aaatgaacat 2640 ttgggactcc tggggccata tataagagca gaagttgaag ataatatcat ggtaactttc 2700 agaaatcagg cctctcgtcc ctattccttc tattctagcc ttatttctta tgaggaagat 2760 cagaggcaag gagcagaacc tagaaaaaac tttgtcaagc ctaatgaaac caaaacttac 2820 ttttggaaag tgcaacatca tatggcaccc actaaagatg agtttgactg caaagcctgg 2880 gcttatttct ctgatgttga cctggaaaaa gatgtgcact caggcctgat tggacccctt 2940 ctggtctgcc acactaacac actgaaccct gctcatggga gacaagtgac agtacaggaa 3000 tttgctctgt ttttcaccat ctttgatgag accaaaagct ggtacttcac tgaaaatatg 3060 gaaagaaact gcagggctcc ctgcaatatc cagatggaag atcccacttt taaagagaat 3120 tatcgcttcc atgcaatcaa tggctacata atggatacac tacctggctt agtaatggct 3180 caggatcaaa ggattcgatg gtatctgctc agcatgggca gcaatgaaaa catccattct 3240 attcatttca gtggacatgt gttcactgta cgaaaaaaag aggagtataa aatggcactg 3300 tacaatctct atccaggtgt ttttgagaca gtggaaatgt taccatccaa agctggaatt 3360 tggcgggtgg aatgccttat tggcgagcat ctacatgctg ggatgagcac actttttctg 3420 gtgtacagca ataagtgtca gactcccctg ggaatggctt ctggacacat tagagatttt 3480 cagattacag cttcaggaca atatggacag tgggccccaa agctggccag acttcattat 3540 tccggatcaa tcaatgcctg gagcaccaag gagccctttt cttggatcaa ggtggatctg 3600 ttggcaccaa tgattattca cggcatcaag acccagggtg cccgtcagaa gttctccagc 3660 ctctacatct ctcagtttat catcatgtat agtcttgatg ggaagaagtg gcagacttat 3720 cgaggaaatt ccactggaac cttaatggtc ttctttggca atgtggattc atctgggata 3780 aaacacaata tttttaaccc tccaattatt gctcgataca tccgtttgca cccaactcat 3840 tatagcattc gcagcactct tcgcatggag ttgatgggct gtgatttaaa tagttgcagc 3900 atgccattgg gaatggagag taaagcaata tcagatgcac agattactgc ttcatcctac 3960 tttaccaata tgtttgccac ctggtctcct tcaaaagctc gacttcacct ccaagggagg 4020 agtaatgcct ggagacctca ggtgaataat ccaaaagagt ggctgcaagt ggacttccag 4080 aagacaatga aagtcacagg agtaactact cagggagtaa aatctctgct taccagcatg 4140 tatgtgaagg agttcctcat ctccagcagt caagatggcc atcagtggac tctctttttt 4200 cagaatggca aagtaaaggt ttttcaggga aatcaagact ccttcacacc tgtggtgaac 4260 tctctagacc caccgttact gactcgctac cttcgaattc acccccagag ttgggtgcac 4320 cagattgccc tgaggatgga ggttctgggc tgcgaggcac aggacctcta c 4371 <210> 17 <211> 1438 <212> PRT <213> Secuencia Artificial <220> <223> FVIII BDD (no optimizado; "parental"), Secuencia de Aminoácidos <400> 17 Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 1 5 10 15 Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 20 25 30 Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 35 40 45 Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 50 55 60 Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 65 70 75 80 Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 85 90 95 Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 100 105 110 Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 115 120 125 Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 130 135 140 Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 145 150 155 160 His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 165 170 175 Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 180 185 190 His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 195 200 205 His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 210 215 220 Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 225 230 235 240 Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 245 250 255 Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 260 265 270 Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 275 280 285 Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 290 295 300 Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 305 310 315 320 Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 325 330 335 Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 340 345 350 Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 355 360 365 Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 370 375 380 Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 385 390 395 400 Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 405 410 415 Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 420 425 430 Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 435 440 445 Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 450 455 460 Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 465 470 475 480 Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 485 490 495 His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 500 505 510 Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 515 520 525 Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 530 535 540 Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 545 550 555 560 Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 565 570 575 Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 580 585 590 Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 595 600 605 Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 610 615 620 Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 625 630 635 640 Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 645 650 655 Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 660 665 670 Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 675 680 685 Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 690 695 700 Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 705 710 715 720 Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 725 730 735 Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His 740 745 750 Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile 755 760 765 Asp Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp 770 775 780 Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys 785 790 795 800 Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly 805 810 815 Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser 820 825 830 Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser 835 840 845 Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu 850 855 860 Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr 865 870 875 880 Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile 885 890 895 Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe 900 905 910 Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His 915 920 925 Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe 930 935 940 Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly Pro 945 950 955 960 Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His Gly Arg Gln 965 970 975 Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe Asp Glu Thr 980 985 990 Lys Ser Trp Tyr Phe Thr Glu Asn Met Glu Arg Asn Cys Arg Ala Pro 995 1000 1005 Cys Asn Ile Gln Met Glu Asp Pro Thr Phe Lys Glu Asn Tyr Arg 1010 1015 1020 Phe His Ala Ile Asn Gly Tyr Ile Met Asp Thr Leu Pro Gly Leu 1025 1030 1035 Val Met Ala Gln Asp Gln Arg Ile Arg Trp Tyr Leu Leu Ser Met 1040 1045 1050 Gly Ser Asn Glu Asn Ile His Ser Ile His Phe Ser Gly His Val 1055 1060 1065 Phe Thr Val Arg Lys Lys Glu Glu Tyr Lys Met Ala Leu Tyr Asn 1070 1075 1080 Leu Tyr Pro Gly Val Phe Glu Thr Val Glu Met Leu Pro Ser Lys 1085 1090 1095 Ala Gly Ile Trp Arg Val Glu Cys Leu Ile Gly Glu His Leu His 1100 1105 1110 Ala Gly Met Ser Thr Leu Phe Leu Val Tyr Ser Asn Lys Cys Gln 1115 1120 1125 Thr Pro Leu Gly Met Ala Ser Gly His Ile Arg Asp Phe Gln Ile 1130 1135 1140 Thr Ala Ser Gly Gln Tyr Gly Gln Trp Ala Pro Lys Leu Ala Arg 1145 1150 1155 Leu His Tyr Ser Gly Ser Ile Asn Ala Trp Ser Thr Lys Glu Pro 1160 1165 1170 Phe Ser Trp Ile Lys Val Asp Leu Leu Ala Pro Met Ile Ile His 1175 1180 1185 Gly Ile Lys Thr Gln Gly Ala Arg Gln Lys Phe Ser Ser Leu Tyr 1190 1195 1200 Ile Ser Gln Phe Ile Ile Met Tyr Ser Leu Asp Gly Lys Lys Trp 1205 1210 1215 Gln Thr Tyr Arg Gly Asn Ser Thr Gly Thr Leu Met Val Phe Phe 1220 1225 1230 Gly Asn Val Asp Ser Ser Gly Ile Lys His Asn Ile Phe Asn Pro 1235 1240 1245 Pro Ile Ile Ala Arg Tyr Ile Arg Leu His Pro Thr His Tyr Ser 1250 1255 1260 Ile Arg Ser Thr Leu Arg Met Glu Leu Met Gly Cys Asp Leu Asn 1265 1270 1275 Ser Cys Ser Met Pro Leu Gly Met Glu Ser Lys Ala Ile Ser Asp 1280 1285 1290 Ala Gln Ile Thr Ala Ser Ser Tyr Phe Thr Asn Met Phe Ala Thr 1295 1300 1305 Trp Ser Pro Ser Lys Ala Arg Leu His Leu Gln Gly Arg Ser Asn 1310 1315 1320 Ala Trp Arg Pro Gln Val Asn Asn Pro Lys Glu Trp Leu Gln Val 1325 1330 1335 Asp Phe Gln Lys Thr Met Lys Val Thr Gly Val Thr Thr Gln Gly 1340 1345 1350 Val Lys Ser Leu Leu Thr Ser Met Tyr Val Lys Glu Phe Leu Ile 1355 1360 1365 Ser Ser Ser Gln Asp Gly His Gln Trp Thr Leu Phe Phe Gln Asn 1370 1375 1380 Gly Lys Val Lys Val Phe Gln Gly Asn Gln Asp Ser Phe Thr Pro 1385 1390 1395 Val Val Asn Ser Leu Asp Pro Pro Leu Leu Thr Arg Tyr Leu Arg 1400 1405 1410 Ile His Pro Gln Ser Trp Val His Gln Ile Ala Leu Arg Met Glu 1415 1420 1425 Val Leu Gly Cys Glu Ala Gln Asp Leu Tyr 1430 1435 <210> 18 <211> 450 <212> ADN <213> Secuencia Artificial <220> <223> Secuencia de nucleótidos XTEN <400> 18 ggcgcgccaa catcagagag cgccacccct gaaagtggtc ccgggagcga gccagccaca 60 tctgggtcgg aaacgccagg cacaagtgag tctgcaactc ccgagtccgg acctggctcc 120 gagcctgcca ctagcggctc cgagactccg ggaacttccg agagcgctac accagaaagc 180 ggacccggaa ccagtaccga acctagcgag ggctctgctc cgggcagccc agccggctct 240 cctacatcca cggaggaggg cacttccgaa tccgccaccc cggagtcagg gccaggatct 300 gaacccgcta cctcaggcag tgagacgcca ggaacgagcg agtccgctac accggagagt 360 gggccaggga gccctgctgg atctcctacg tccactgagg aagggtcacc agcgggctcg 420 cccaccagca ctgaagaagg tgcctcgagc 450 <210> 19 <211> 4824 <212> ADN <213> Secuencia Artificial <220> <223> coFVIII-52-XTEN <400> 19 atgcaaatcg aactgagcac ctgtttcttc ctctgcctgc tgagattctg tttctccgcg 60 acccgccgat actacctggg agcagtggag ctctcctggg attacatgca gagcgacctt 120 ggggagctgc ccgtggatgc caggttccct ccccgggtgc caaagtcgtt tccgttcaac 180 acctccgtgg tgtacaagaa aactctgttc gtggagttca ccgaccacct gttcaatatc 240 gccaagccca gacctccctg gatggggctg ttgggaccta ccatccaagc ggaggtgtac 300 gacactgtgg tcatcactct gaagaacatg gcctcgcatc ccgtgtccct gcacgccgtg 360 ggagtgtctt actggaaagc gtccgagggg gccgaatacg acgaccagac ctcgcagaga 420 gaaaaggaag atgacaaggt gttcccagga ggatcgcaca cctacgtgtg gcaagtgttg 480 aaggagaacg gcccaatggc ctccgacccg ctgtgcctga cctactcgta cctgtcccac 540 gtggacctcg tgaaggacct caactcggga ctgattggag ccctgctggt ctgcagggaa 600 ggctcactgg cgaaagaaaa gactcagacc ttgcacaagt tcattctgct gttcgctgtg 660 ttcgacgagg ggaagtcgtg gcacagcgag actaagaact ccctgatgca agatagagat 720 gccgcctccg cccgggcctg gcctaagatg cacaccgtga acggttacgt gaaccgctcc 780 ctccctggcc tgattggatg ccaccggaag tccgtgtact ggcacgtgat cgggatgggg 840 accacccccg aggtgcacag catcttcctg gaaggtcaca catttctcgt gcgcaaccac 900 cggcaggcct ccctggaaat cagccccatt accttcctca ctgcccagac tctgctgatg 960 gacctgggac agttcctgct gttctgccat atctcctccc accaacatga cggaatggag 1020 gcatacgtga aggtcgattc ctgccctgag gaaccccagc tccgcatgaa gaacaatgag 1080 gaagccgagg actacgacga cgacctgacg gatagcgaga tggatgtggt ccggttcgat 1140 gacgataaca gcccttcctt catccaaatt cgctcggtgg caaagaagca ccccaagacc 1200 tgggtgcatt acattgcggc ggaagaagag gactgggatt atgccccgct tgtcctcgct 1260 cctgacgacc ggagctacaa gagccagtac ctgaacaacg gtccacagag gatcggtaga 1320 aagtacaaga aggtccgctt catggcctat accgacgaaa ccttcaaaac tagagaggcc 1380 atccaacacg aatccggcat cctgggcccg ctcttgtacg gagaagtcgg cgacaccctt 1440 ctcattatct tcaagaacca ggcttcccgg ccgtacaaca tctatccgca tgggatcact 1500 gacgtgcgcc cactgtactc gcggcgcctg cccaagggtg tcaaacacct gaaggatttt 1560 ccgatccttc cgggagaaat cttcaagtac aagtggaccg tgaccgtgga agatggccca 1620 actaagtctg accctagatg cctcacccgc tactactcat ccttcgtcaa catggagcgc 1680 gacctggcca gcggactgat cggcccgctg ctgatttgct acaaggaatc agtggaccaa 1740 cggggaaacc agatcatgtc ggataagagg aacgtcatcc tcttctccgt gtttgacgaa 1800 aaccggtcgt ggtacctgac cgagaacatc cagaggttcc tgcccaaccc tgctggggtg 1860 cagctggagg accccgagtt ccaggccagc aacatcatgc acagcatcaa tggctacgtg 1920 ttcgacagcc tgcagctgag cgtgtgcctg cacgaggtgg cctactggta catcctgagc 1980 atcggcgccc agaccgactt cctgagcgtg ttcttctctg gctacacctt caagcacaag 2040 atggtgtatg aggacaccct gaccctgttc cccttcagcg gggagactgt cttcatgagc 2100 atggagaacc ctggcctgtg gatcctgggc tgccacaaca gcgacttcag gaacaggggc 2160 atgactgccc tgctgaaagt ctccagctgt gacaagaaca ccggggacta ctacgaggac 2220 agctacgagg acatcagcgc ctacctgctg agcaagaaca atgccatcga gcccaggagc 2280 ttctctcaga acggcgcgcc aacatcagag agcgccaccc ctgaaagtgg tcccgggagc 2340 gagccagcca catctgggtc ggaaacgcca ggcacaagtg agtctgcaac tcccgagtcc 2400 ggacctggct ccgagcctgc cactagcggc tccgagactc cgggaacttc cgagagcgct 2460 acaccagaaa gcggacccgg aaccagtacc gaacctagcg agggctctgc tccgggcagc 2520 ccagccggct ctcctacatc cacggaggag ggcacttccg aatccgccac cccggagtca 2580 gggccaggat ctgaacccgc tacctcaggc agtgagacgc caggaacgag cgagtccgct 2640 acaccggaga gtgggccagg gagccctgct ggatctccta cgtccactga ggaagggtca 2700 ccagcgggct cgcccaccag cactgaagaa ggtgcctcga gccccccagt gctgaagagg 2760 caccagaggg agatcaccag gaccaccctg cagtctgacc aggaggagat cgactatgat 2820 gacaccatca gcgtggagat gaagaaggag gacttcgaca tctacgacga ggacgagaac 2880 cagagcccca ggagcttcca gaagaagacc aggcactact tcattgctgc tgtggagagg 2940 ctgtgggact atggcatgtc cagcagcccc catgtgctga ggaacagggc ccagtctggc 3000 agcgtgcccc agttcaagaa agtcgtgttc caggagttca ccgacggcag cttcacccag 3060 cccctgtaca gaggggagct gaacgagcac ctgggcctgc tgggccccta catcagggcc 3120 gaggtggagg acaacatcat ggtgaccttc aggaaccagg ccagcaggcc ctacagcttc 3180 tacagcagcc tgatcagcta cgaggaggac cagaggcagg gggctgagcc caggaagaac 3240 tttgtgaagc ccaatgaaac caagacctac ttctggaagg tgcagcacca catggccccc 3300 accaaggacg agttcgactg caaggcctgg gcctacttct ctgacgtgga cctggagaag 3360 gacgtgcact ctggcctgat tggccccctg ctggtgtgcc acaccaacac cctgaaccct 3420 gcccatggca ggcaggtgac tgtgcaggag ttcgccctgt tcttcaccat cttcgatgaa 3480 accaagagct ggtacttcac tgagaacatg gagaggaact gcagggcccc ctgcaacatc 3540 cagatggagg accccacctt caaggagaac tacaggttcc atgccatcaa tggctacatc 3600 atggacaccc tgcctggcct ggtcatggcc caggaccaga ggatcaggtg gtatctgctg 3660 agcatgggca gcaacgagaa catccacagc atccacttct ctggccacgt gttcactgtg 3720 aggaagaagg aggagtacaa gatggccctg tacaacctgt accctggggt gttcgaaacc 3780 gtggagatgc tgcccagcaa ggccggcatc tggagggtgg agtgcctgat tggggagcac 3840 ctgcacgccg gcatgagcac cctgttcctg gtgtacagca acaagtgcca gacccccctg 3900 ggcatggcct ctggccacat cagggacttc cagatcactg cctctggcca gtacggccag 3960 tgggccccca agctggccag gctgcactac tccggaagca tcaatgcctg gagcaccaag 4020 gagcccttca gctggatcaa agtggacctg ctggccccca tgatcatcca cggcatcaag 4080 acccaggggg ccaggcagaa gttctccagc ctgtacatca gccagttcat catcatgtac 4140 agcctggacg gcaagaagtg gcagacctac aggggcaaca gcaccggcac cctgatggtg 4200 ttcttcggca acgtggacag cagcggcatc aagcacaaca tcttcaaccc ccccatcatc 4260 gccagataca tcaggctgca ccccacccac tacagcatca ggagcaccct gaggatggag 4320 ctgatgggct gtgacctgaa cagctgcagc atgcccctgg gcatggagag caaggccatc 4380 tctgacgccc agatcactgc ctccagctac ttcaccaaca tgtttgccac ctggagcccc 4440 agcaaggcca ggctgcacct gcagggcagg agcaatgcct ggaggcccca ggtcaacaac 4500 cccaaggagt ggctgcaggt ggacttccag aagaccatga aggtgactgg ggtgaccacc 4560 cagggggtga agagcctgct gaccagcatg tacgtgaagg agttcctgat ctccagcagc 4620 caggacggcc accagtggac cctgttcttc cagaatggca aggtgaaggt gttccagggc 4680 aaccaggaca gcttcacccc tgtggtcaac agcctggacc cccccctgct gaccagatac 4740 ctgaggatcc acccccagag ctgggtgcac cagatcgccc tgaggatgga ggtgctgggc 4800 tgtgaggccc aggacctgta ctga 4824 <210> 20 <211> 4824 <212> ADN <213> Secuencia Artificial <220> <223> coFVIII-1-XTEN <400> 20 atgcagattg agctgtctac ttgctttttc ctgtgcctgc tgaggttttg cttttccgct 60 acacgaaggt attatctggg ggctgtggaa ctgtcttggg attacatgca gagtgacctg 120 ggagagctgc cagtggacgc aaggtttccc cctagagtcc ctaagtcatt ccccttcaac 180 actagcgtgg tctacaagaa aacactgttc gtggagttta ctgatcacct gttcaacatc 240 gcaaagccta ggccaccctg gatgggactg ctggggccaa caatccaggc cgaggtgtac 300 gacaccgtgg tcattacact taagaacatg gcctcacacc ccgtgagcct gcatgctgtg 360 ggcgtcagct actggaaggc ttccgaagga gcagagtatg acgatcagac ttcccagaga 420 gaaaaagagg acgataaggt gtttcctggc ggatctcata cctacgtgtg gcaggtcctg 480 aaagagaatg gccctatggc ctccgaccct ctgtgcctga cctactctta tctgagtcac 540 gtggacctgg tcaaggatct gaacagcggc ctgatcggag ccctgctggt gtgcagggaa 600 ggaagcctgg ctaaggagaa aacccagaca ctgcataagt tcattctgct gttcgccgtg 660 tttgacgaag ggaaatcatg gcacagcgag acaaagaata gtctgatgca ggacagggat 720 gccgcttcag ccagagcttg gcccaaaatg cacactgtga acggctacgt caatcgctca 780 ctgcctgggc tgatcggctg ccaccgaaag agcgtgtatt ggcatgtcat cgggatgggc 840 accacacctg aagtgcactc cattttcctg gagggacata cctttctggt ccgcaaccac 900 cgacaggctt ccctggagat ctctccaatt accttcctga cagcacagac tctgctgatg 960 gacctggggc agttcctgct gttttgccac atcagctccc accagcatga tggcatggag 1020 gcttacgtga aagtggactc ttgtcccgag gaacctcagc tgcggatgaa gaacaatgag 1080 gaagcagaag actatgacga tgacctgacc gactccgaga tggatgtggt ccgattcgat 1140 gacgataaca gcccctcctt tatccagatt agatctgtgg ccaagaaaca ccctaagaca 1200 tgggtccatt acatcgcagc cgaggaagag gactgggatt atgcaccact ggtgctggca 1260 ccagacgatc gctcctacaa atctcagtat ctgaacaatg ggccacagag gattggcaga 1320 aagtacaaga aagtgcggtt catggcatat accgatgaga ccttcaagac tcgcgaagcc 1380 atccagcacg agagcggcat cctgggacca ctgctgtacg gagaagtggg agacaccctg 1440 ctgatcattt tcaagaacca ggccagccgg ccttacaata tctatccaca tgggattaca 1500 gatgtgcgcc ctctgtacag caggagactg ccaaagggcg tcaaacacct gaaggacttc 1560 ccaatcctgc ccggagaaat cttcaagtac aagtggactg tcaccgtcga ggatggcccc 1620 actaagagcg accctcggtg cctgacccgc tactattcta gtttcgtgaa tatggaaaga 1680 gatctggcaa gcggactgat cggaccactg ctgatttgtt acaaagagag cgtggatcag 1740 agaggcaacc agatcatgtc cgacaagcgg aatgtgattc tgttcagtgt ctttgacgaa 1800 aacaggtcat ggtacctgac cgagaacatc cagagattcc tgcctaatcc agctggggtg 1860 cagctggaag atcctgagtt tcaggcatct aacatcatgc atagtattaa tggctacgtg 1920 ttcgacagtt tgcagctgag cgtgtgcctg cacgaggtcg cttactggta tatcctgagc 1980 attggggcac agacagattt cctgagcgtg ttcttttccg gctacacttt taagcataaa 2040 atggtctatg aggacacact gactctgttc cccttcagcg gcgaaaccgt gtttatgagc 2100 atggagaatc ccggactgtg gattctgggg tgccacaaca gcgatttcag aaatcgcgga 2160 atgactgccc tgctgaaagt gtcaagctgt gacaagaaca ccggggacta ctatgaagat 2220 tcatacgagg acatcagcgc atatctgctg tccaaaaaca atgccattga accccggtct 2280 tttagtcaga atggcgcgcc aacatcagag agcgccaccc ctgaaagtgg tcccgggagc 2340 gagccagcca catctgggtc ggaaacgcca ggcacaagtg agtctgcaac tcccgagtcc 2400 ggacctggct ccgagcctgc cactagcggc tccgagactc cgggaacttc cgagagcgct 2460 acaccagaaa gcggacccgg aaccagtacc gaacctagcg agggctctgc tccgggcagc 2520 ccagccggct ctcctacatc cacggaggag ggcacttccg aatccgccac cccggagtca 2580 gggccaggat ctgaacccgc tacctcaggc agtgagacgc caggaacgag cgagtccgct 2640 acaccggaga gtgggccagg gagccctgct ggatctccta cgtccactga ggaagggtca 2700 ccagcgggct cgcccaccag cactgaagaa ggtgcctcga gccctccagt gctgaagcgg 2760 caccagcgcg agatcacccg cactaccctg cagagtgatc aggaagagat cgactacgac 2820 gatacaattt ctgtggaaat gaagaaagag gacttcgata tctatgacga agatgagaac 2880 cagagtcctc gatcattcca gaagaaaacc aggcattact ttattgccgc agtggagcgg 2940 ctgtgggatt atggcatgtc ctctagtcct cacgtgctgc gaaatagggc ccagtcagga 3000 agcgtcccac agttcaagaa agtggtcttc caggagttta cagacgggtc ctttactcag 3060 ccactgtaca ggggcgaact gaacgagcac ctgggactgc tggggcccta tatcagagca 3120 gaagtggagg ataacattat ggtcaccttc agaaatcagg cctctcggcc ttacagtttt 3180 tattcaagcc tgatctctta cgaagaggac cagcgacagg gagctgaacc acgaaaaaac 3240 ttcgtgaagc ctaatgagac caaaacatac ttttggaagg tgcagcacca tatggcccca 3300 acaaaagacg agttcgattg caaggcatgg gcctattttt ctgacgtgga tctggagaag 3360 gacgtgcaca gtggcctgat tggcccactg ctggtgtgcc atactaacac cctgaatcca 3420 gcccacggcc ggcaggtcac tgtccaggag ttcgctctgt tctttaccat ctttgatgag 3480 acaaagagct ggtacttcac cgaaaacatg gagcgaaatt gcagggctcc atgtaacatt 3540 cagatggaag accccacatt caaggagaac taccgctttc atgctatcaa tggatacatc 3600 atggatactc tgcccgggct ggtcatggca caggaccaga gaatccggtg gtatctgctg 3660 agcatgggca gcaacgagaa tatccactca attcatttca gcgggcacgt gtttactgtc 3720 aggaagaaag aagagtacaa gatggccctg tacaacctgt atcccggcgt gttcgaaacc 3780 gtcgagatgc tgcctagcaa ggccggaatc tggagagtgg aatgcctgat tggagagcac 3840 ctgcatgctg ggatgtctac cctgtttctg gtgtacagta ataagtgtca gacacccctg 3900 ggaatggcat ccgggcatat cagggatttc cagattaccg catctggaca gtacggacag 3960 tgggcaccta agctggctag actgcactat tccggatcta tcaacgcttg gtccacaaaa 4020 gagcctttct cttggattaa ggtggacctg ctggccccaa tgatcattca tggcatcaaa 4080 actcagggag ctcggcagaa gttctcctct ctgtacatct cacagtttat catcatgtac 4140 agcctggatg ggaagaaatg gcagacatac cgcggcaata gcacaggaac tctgatggtg 4200 ttctttggca acgtggacag cagcggaatc aagcacaaca ttttcaatcc ccctatcatt 4260 gctagataca tccggctgca cccaacccat tattctattc gaagtacact gaggatggaa 4320 ctgatgggat gcgatctgaa cagttgttca atgcccctgg ggatggagtc caaggcaatc 4380 tctgacgccc agattaccgc cagctcctac ttcactaata tgtttgctac ctggagccct 4440 tccaaagcaa gactgcacct gcaaggccgc agcaacgcat ggcgaccaca ggtgaacaat 4500 cccaaggagt ggttgcaggt cgattttcag aaaactatga aggtgaccgg ggtcacaact 4560 cagggcgtga aaagtctgct gacctcaatg tacgtcaagg agttcctgat ctctagttca 4620 caggacggac atcagtggac actgttcttt cagaacggga aggtgaaagt cttccagggc 4680 aatcaggatt cctttacacc tgtggtcaac agtctagacc ctccactgct gaccagatac 4740 ctgagaatcc accctcagtc ctgggtgcac cagattgccc tgagaatgga agtgctggga 4800 tgcgaggccc aggatctgta ctga 4824 <210> 21 <211> 6 <212> ADN <213> Secuencia Artificial <220> <223> MAR/ARS <400> 21 atattt 6 <210> 22 <211> 6 <212> ADN <213> Secuencia Artificial <220> <223> MAR/ARS <400> 22 aaatat 6 <210> 23 <211> 5 <212> ADN <213> Secuencia Artificial <220> <223> elemento desestabilizador <400> 23 attta 5 <210> 24 <211> 5 <212> ADN <213> Secuencia Artificial <220> <223> elemento destabilizador <400> 24 taaat 5 <210> 25 <211> 6 <212> ADN <213> Secuencia Artificial <220> <223> Sitio poli-T <400> 25 tttttt 6 <210> 26 <211> 7 <212> ADN <213> Secuencia Artificial <220> <223> Sitio poli-A <400> 26 aaaaaaa 7 <210> 27 <211> 6 <212> ADN <213> Secuencia Artificial <220> <223> sitio de corte y empalme <400> 27 ggtgat 6 <210> 28 <211> 5 <212> ADN <213> Secuencia Artificial <220> <223> Caja TATA <400> 28 tataa 5 <210> 29 <211> 5 <212> ADN <213> Secuencia Artificial <220> <223> Caja TATA <400> 29 ttata 5 <210> 30 <211> 8 <212> ADN <213> Secuencia Artificial <220> <223> Elemento de secuencia rico en AU <400> 30 attttatt 8 <210> 31 <211> 8 <212> ADN <213> Secuencia Artificial <220> <223> Elemento de secuencia rico en AU <400> 31 atttttaa 8 <210> 32 <211> 13 <212> ADN <213> Secuencia Artificial <220> <223> Secuencia consenso de kozak <400> 32 gccgccacca tgc 13 <210> 33 <211> 32 <212> PRT <213> Secuencia Artificial <220> <223> Péptido CTP <400> 33 Asp Pro Arg Phe Gln Asp Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser 1 5 10 15 Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu 20 25 30 <210> 34 <211> 28 <212> PRT <213> Secuencia Artificial <220> <223> Péptido CTP <400> 34 Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg 1 5 10 15 Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln 20 25 <210> 35 <211> 11 <212> PRT <213> Secuencia Artificial <220> <223> Secuencia central del péptido de unión a albúmina <400> 35 Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 1 5 10 <210> 36 <211> 20 <212> PRT <213> Secuencia Artificial <220> <223> Secuencia PAS <400> 36 Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro 1 5 10 15 Ser Ala Pro Ala 20 <210> 37 <211> 20 <212> PRT <213> Secuencia Artificial <220> <223> Secuencia PAS <400> 37 Ala Ala Pro Ala Ser Pro Ala Pro Ala Ala Pro Ser Ala Pro Ala Pro 1 5 10 15 Ala Ala Pro Ser 20 <210> 38 <211> 20 <212> PRT <213> Secuencia Artificial <220> <223> Secuencia PAS <400> 38 Ala Pro Ser Ser Pro Ser Pro Ser Ala Pro Ser Ser Pro Ser Pro Ala 1 5 10 15 Ser Pro Ser Ser 20 <210> 39 <211> 19 <212> PRT <213> Secuencia Artificial <220> <223> Secuencia PAS <400> 39 Ala Pro Ser Ser Pro Ser Pro Ser Ala Pro Ser Ser Pro Ser Pro Ala 1 5 10 15 Ser Pro Ser <210> 40 <211> 20 <212> PRT <213> Secuencia Artificial <220> <223> Secuencia PAS <400> 40 Ser Ser Pro Ser Ala Pro Ser Pro Ser Ser Pro Ala Ser Pro Ser Pro 1 5 10 15 Ser Ser Pro Ala 20 <210> 41 <211> 24 <212> PRT <213> Secuencia Artificial <220> <223> Secuencia PAS <400> 41 Ala Ala Ser Pro Ala Ala Pro Ser Ala Pro Pro Ala Ala Ala Ser Pro 1 5 10 15 Ala Ala Pro Ser Ala Pro Pro Ala 20 <210> 42 <211> 20 <212> PRT <213> Secuencia Artificial <220> <223> Secuencia PAS <400> 42 Ala Ser Ala Ala Ala Pro Ala Ala Ala Ser Ala Ala Ala Ser Ala Pro 1 5 10 15 Ser Ala Ala Ala 20 <210> 43 <211> 23 <212> ADN <213> Secuencia Artificial <220> <223> Diana de miR142 <400> 43 tccataaagt aggaaacact aca 23 <210> 44 <211> 2332 <212> PRT <213> Homo sapiens <400> 44 Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 1 5 10 15 Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 20 25 30 Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 35 40 45 Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 50 55 60 Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 65 70 75 80 Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 85 90 95 Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 100 105 110 Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 115 120 125 Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 130 135 140 Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 145 150 155 160 His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 165 170 175 Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 180 185 190 His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 195 200 205 His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 210 215 220 Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 225 230 235 240 Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 245 250 255 Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 260 265 270 Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 275 280 285 Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 290 295 300 Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 305 310 315 320 Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 325 330 335 Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 340 345 350 Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 355 360 365 Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 370 375 380 Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 385 390 395 400 Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 405 410 415 Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 420 425 430 Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 435 440 445 Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 450 455 460 Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 465 470 475 480 Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 485 490 495 His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 500 505 510 Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 515 520 525 Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 530 535 540 Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 545 550 555 560 Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 565 570 575 Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 580 585 590 Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 595 600 605 Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 610 615 620 Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 625 630 635 640 Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 645 650 655 Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 660 665 670 Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 675 680 685 Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 690 695 700 Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 705 710 715 720 Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 725 730 735 Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg 740 745 750 Gln Lys Gln Phe Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys 755 760 765 Thr Asp Pro Trp Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn 770 775 780 Val Ser Ser Ser Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro 785 790 795 800 His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe 805 810 815 Ser Asp Asp Pro Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser 820 825 830 Glu Met Thr His Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val 835 840 845 Phe Thr Pro Glu Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly 850 855 860 Thr Thr Ala Ala Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser 865 870 875 880 Thr Ser Asn Asn Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala 885 890 895 Gly Thr Asp Asn Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His 900 905 910 Tyr Asp Ser Gln Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro 915 920 925 Leu Thr Glu Ser Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp 930 935 940 Ser Lys Leu Leu Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp 945 950 955 960 Gly Lys Asn Val Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys 965 970 975 Arg Ala His Gly Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys 980 985 990 Val Ser Ile Ser Leu Leu Lys Thr Asn Lys Thr Ser Asn Asn Ser Ala 995 1000 1005 Thr Asn Arg Lys Thr His Ile Asp Gly Pro Ser Leu Leu Ile Glu 1010 1015 1020 Asn Ser Pro Ser Val Trp Gln Asn Ile Leu Glu Ser Asp Thr Glu 1025 1030 1035 Phe Lys Lys Val Thr Pro Leu Ile His Asp Arg Met Leu Met Asp 1040 1045 1050 Lys Asn Ala Thr Ala Leu Arg Leu Asn His Met Ser Asn Lys Thr 1055 1060 1065 Thr Ser Ser Lys Asn Met Glu Met Val Gln Gln Lys Lys Glu Gly 1070 1075 1080 Pro Ile Pro Pro Asp Ala Gln Asn Pro Asp Met Ser Phe Phe Lys 1085 1090 1095 Met Leu Phe Leu Pro Glu Ser Ala Arg Trp Ile Gln Arg Thr His 1100 1105 1110 Gly Lys Asn Ser Leu Asn Ser Gly Gln Gly Pro Ser Pro Lys Gln 1115 1120 1125 Leu Val Ser Leu Gly Pro Glu Lys Ser Val Glu Gly Gln Asn Phe 1130 1135 1140 Leu Ser Glu Lys Asn Lys Val Val Val Gly Lys Gly Glu Phe Thr 1145 1150 1155 Lys Asp Val Gly Leu Lys Glu Met Val Phe Pro Ser Ser Arg Asn 1160 1165 1170 Leu Phe Leu Thr Asn Leu Asp Asn Leu His Glu Asn Asn Thr His 1175 1180 1185 Asn Gln Glu Lys Lys Ile Gln Glu Glu Ile Glu Lys Lys Glu Thr 1190 1195 1200 Leu Ile Gln Glu Asn Val Val Leu Pro Gln Ile His Thr Val Thr 1205 1210 1215 Gly Thr Lys Asn Phe Met Lys Asn Leu Phe Leu Leu Ser Thr Arg 1220 1225 1230 Gln Asn Val Glu Gly Ser Tyr Asp Gly Ala Tyr Ala Pro Val Leu 1235 1240 1245 Gln Asp Phe Arg Ser Leu Asn Asp Ser Thr Asn Arg Thr Lys Lys 1250 1255 1260 His Thr Ala His Phe Ser Lys Lys Gly Glu Glu Glu Asn Leu Glu 1265 1270 1275 Gly Leu Gly Asn Gln Thr Lys Gln Ile Val Glu Lys Tyr Ala Cys 1280 1285 1290 Thr Thr Arg Ile Ser Pro Asn Thr Ser Gln Gln Asn Phe Val Thr 1295 1300 1305 Gln Arg Ser Lys Arg Ala Leu Lys Gln Phe Arg Leu Pro Leu Glu 1310 1315 1320 Glu Thr Glu Leu Glu Lys Arg Ile Ile Val Asp Asp Thr Ser Thr 1325 1330 1335 Gln Trp Ser Lys Asn Met Lys His Leu Thr Pro Ser Thr Leu Thr 1340 1345 1350 Gln Ile Asp Tyr Asn Glu Lys Glu Lys Gly Ala Ile Thr Gln Ser 1355 1360 1365 Pro Leu Ser Asp Cys Leu Thr Arg Ser His Ser Ile Pro Gln Ala 1370 1375 1380 Asn Arg Ser Pro Leu Pro Ile Ala Lys Val Ser Ser Phe Pro Ser 1385 1390 1395 Ile Arg Pro Ile Tyr Leu Thr Arg Val Leu Phe Gln Asp Asn Ser 1400 1405 1410 Ser His Leu Pro Ala Ala Ser Tyr Arg Lys Lys Asp Ser Gly Val 1415 1420 1425 Gln Glu Ser Ser His Phe Leu Gln Gly Ala Lys Lys Asn Asn Leu 1430 1435 1440 Ser Leu Ala Ile Leu Thr Leu Glu Met Thr Gly Asp Gln Arg Glu 1445 1450 1455 Val Gly Ser Leu Gly Thr Ser Ala Thr Asn Ser Val Thr Tyr Lys 1460 1465 1470 Lys Val Glu Asn Thr Val Leu Pro Lys Pro Asp Leu Pro Lys Thr 1475 1480 1485 Ser Gly Lys Val Glu Leu Leu Pro Lys Val His Ile Tyr Gln Lys 1490 1495 1500 Asp Leu Phe Pro Thr Glu Thr Ser Asn Gly Ser Pro Gly His Leu 1505 1510 1515 Asp Leu Val Glu Gly Ser Leu Leu Gln Gly Thr Glu Gly Ala Ile 1520 1525 1530 Lys Trp Asn Glu Ala Asn Arg Pro Gly Lys Val Pro Phe Leu Arg 1535 1540 1545 Val Ala Thr Glu Ser Ser Ala Lys Thr Pro Ser Lys Leu Leu Asp 1550 1555 1560 Pro Leu Ala Trp Asp Asn His Tyr Gly Thr Gln Ile Pro Lys Glu 1565 1570 1575 Glu Trp Lys Ser Gln Glu Lys Ser Pro Glu Lys Thr Ala Phe Lys 1580 1585 1590 Lys Lys Asp Thr Ile Leu Ser Leu Asn Ala Cys Glu Ser Asn His 1595 1600 1605 Ala Ile Ala Ala Ile Asn Glu Gly Gln Asn Lys Pro Glu Ile Glu 1610 1615 1620 Val Thr Trp Ala Lys Gln Gly Arg Thr Glu Arg Leu Cys Ser Gln 1625 1630 1635 Asn Pro Pro Val Leu Lys Arg His Gln Arg Glu Ile Thr Arg Thr 1640 1645 1650 Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp Asp Thr Ile 1655 1660 1665 Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp Glu Asp 1670 1675 1680 Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr 1685 1690 1695 Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser 1700 1705 1710 Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val Pro 1715 1720 1725 Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe 1730 1735 1740 Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu 1745 1750 1755 Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val 1760 1765 1770 Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser 1775 1780 1785 Leu Ile Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg 1790 1795 1800 Lys Asn Phe Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys 1805 1810 1815 Val Gln His His Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys 1820 1825 1830 Ala Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys Asp Val His 1835 1840 1845 Ser Gly Leu Ile Gly Pro Leu Leu Val Cys His Thr Asn Thr Leu 1850 1855 1860 Asn Pro Ala His Gly Arg Gln Val Thr Val Gln Glu Phe Ala Leu 1865 1870 1875 Phe Phe Thr Ile Phe Asp Glu Thr Lys Ser Trp Tyr Phe Thr Glu 1880 1885 1890 Asn Met Glu Arg Asn Cys Arg Ala Pro Cys Asn Ile Gln Met Glu 1895 1900 1905 Asp Pro Thr Phe Lys Glu Asn Tyr Arg Phe His Ala Ile Asn Gly 1910 1915 1920 Tyr Ile Met Asp Thr Leu Pro Gly Leu Val Met Ala Gln Asp Gln 1925 1930 1935 Arg Ile Arg Trp Tyr Leu Leu Ser Met Gly Ser Asn Glu Asn Ile 1940 1945 1950 His Ser Ile His Phe Ser Gly His Val Phe Thr Val Arg Lys Lys 1955 1960 1965 Glu Glu Tyr Lys Met Ala Leu Tyr Asn Leu Tyr Pro Gly Val Phe 1970 1975 1980 Glu Thr Val Glu Met Leu Pro Ser Lys Ala Gly Ile Trp Arg Val 1985 1990 1995 Glu Cys Leu Ile Gly Glu His Leu His Ala Gly Met Ser Thr Leu 2000 2005 2010 Phe Leu Val Tyr Ser Asn Lys Cys Gln Thr Pro Leu Gly Met Ala 2015 2020 2025 Ser Gly His Ile Arg Asp Phe Gln Ile Thr Ala Ser Gly Gln Tyr 2030 2035 2040 Gly Gln Trp Ala Pro Lys Leu Ala Arg Leu His Tyr Ser Gly Ser 2045 2050 2055 Ile Asn Ala Trp Ser Thr Lys Glu Pro Phe Ser Trp Ile Lys Val 2060 2065 2070 Asp Leu Leu Ala Pro Met Ile Ile His Gly Ile Lys Thr Gln Gly 2075 2080 2085 Ala Arg Gln Lys Phe Ser Ser Leu Tyr Ile Ser Gln Phe Ile Ile 2090 2095 2100 Met Tyr Ser Leu Asp Gly Lys Lys Trp Gln Thr Tyr Arg Gly Asn 2105 2110 2115 Ser Thr Gly Thr Leu Met Val Phe Phe Gly Asn Val Asp Ser Ser 2120 2125 2130 Gly Ile Lys His Asn Ile Phe Asn Pro Pro Ile Ile Ala Arg Tyr 2135 2140 2145 Ile Arg Leu His Pro Thr His Tyr Ser Ile Arg Ser Thr Leu Arg 2150 2155 2160 Met Glu Leu Met Gly Cys Asp Leu Asn Ser Cys Ser Met Pro Leu 2165 2170 2175 Gly Met Glu Ser Lys Ala Ile Ser Asp Ala Gln Ile Thr Ala Ser 2180 2185 2190 Ser Tyr Phe Thr Asn Met Phe Ala Thr Trp Ser Pro Ser Lys Ala 2195 2200 2205 Arg Leu His Leu Gln Gly Arg Ser Asn Ala Trp Arg Pro Gln Val 2210 2215 2220 Asn Asn Pro Lys Glu Trp Leu Gln Val Asp Phe Gln Lys Thr Met 2225 2230 2235 Lys Val Thr Gly Val Thr Thr Gln Gly Val Lys Ser Leu Leu Thr 2240 2245 2250 Ser Met Tyr Val Lys Glu Phe Leu Ile Ser Ser Ser Gln Asp Gly 2255 2260 2265 His Gln Trp Thr Leu Phe Phe Gln Asn Gly Lys Val Lys Val Phe 2270 2275 2280 Gln Gly Asn Gln Asp Ser Phe Thr Pro Val Val Asn Ser Leu Asp 2285 2290 2295 Pro Pro Leu Leu Thr Arg Tyr Leu Arg Ile His Pro Gln Ser Trp 2300 2305 2310 Val His Gln Ile Ala Leu Arg Met Glu Val Leu Gly Cys Glu Ala 2315 2320 2325 Gln Asp Leu Tyr 2330 <210> 45 <211> 4 <212> PRT <213> Secuencia Artificial <220> <223> Aminoácidos 233-236 de IgG1 humana <400> 45 Glu Leu Leu Gly 1 <210> 46 <211> 42 <212> PRT <213> Secuencia Artificial <220> <223> XTEN AE42-4, secuencia de proteína <400> 46 Gly Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 1 5 10 15 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 20 25 30 Thr Ser Gly Ser Glu Thr Pro Ala Ser Ser 35 40 <210> 47 <211> 126 <212> ADN <213> Secuencia Artificial <220> <223> XTEN AE42-4, secuencia de ADN <400> 47 ggcgcgccag gttctcctgc tggctccccc acctcaacag aagaggggac aagcgaaagc 60 gctacgcctg agagtggccc tggctctgag ccagccacct ccggctctga aacccctgcc 120 tcgagc 126 <210> 48 <211> 144 <212> PRT <213> Secuencia Artificial <220> <223> XTEN AE144-2A, secuencia de proteína <400> 48 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly 1 5 10 15 Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly 20 25 30 Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 35 40 45 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu 50 55 60 Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 65 70 75 80 Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 85 90 95 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu 100 105 110 Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 115 120 125 Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 130 135 140 <210> 49 <211> 450 <212> ADN <213> Secuencia Artificial <220> <223> XTEN AE144-2A, secuencia de ADN <400> 49 ggcgcgccaa ccagtacgga gccgtccgag gggagcgcac caggaagccc ggctgggagc 60 ccgacttcta ccgaagaggg tacatctacc gaaccaagtg aaggttcagc accaggcacc 120 tcaacagaac cctctgaggg ctcggcgcct ggtacaagtg agtccgccac cccagaatcc 180 gggcctggga caagcacaga accttcggaa gggagtgccc ctggaacatc cgaatcggca 240 accccagaat cagggccagg atctgagccc gcgacttcgg gctccgagac gcctgggaca 300 tccaccgagc cctccgaagg atcagcccca ggcaccagca cggagccctc tgagggaagc 360 gcacctggta ccagcgaaag cgcaactccc gaatcaggtc ccggtacgag cgagtcggcg 420 accccggaga gcgggccagg tgcctcgagc 450 <210> 50 <211> 144 <212> PRT <213> Secuencia Artificial <220> <223> XTEN AE144-3B, secuencia de proteína <400> 50 Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser 1 5 10 15 Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 20 25 30 Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 35 40 45 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu 50 55 60 Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 65 70 75 80 Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 85 90 95 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu 100 105 110 Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 115 120 125 Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 130 135 140 <210> 51 <211> 450 <212> ADN <213> Secuencia Artificial <220> <223> XTEN AE144-3B, secuencia de ADN <400> 51 ggcgcgccaa gtcccgctgg aagcccaact agcaccgaag aggggacctc agagtccgcc 60 acccccgagt ccggccctgg ctctgagcct gccactagcg gctccgagac tcctggcaca 120 tccgaaagcg ctacacccga gagtggaccc ggcacctcta ccgagcccag tgagggctcc 180 gcccctggaa caagcaccga gcccagcgaa ggcagcgccc cagggacctc cacagagccc 240 agtgaaggca gtgctcctgg caccagcacc gaaccaagcg agggctctgc acccgggacc 300 tccaccgagc caagcgaagg ctctgcccct ggcacttcca ccgagcccag cgaaggcagc 360 gcccctggga gccccgctgg ctctcccacc agcactgagg agggcacatc taccgaacca 420 agtgaaggct ctgcaccagg tgcctcgagc 450 <210> 52 <211> 144 <212> PRT <213> Secuencia Artificial <220> <223> XTEN AE144-4A, secuencia de proteína <400> 52 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 1 5 10 15 Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 20 25 30 Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 35 40 45 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu 50 55 60 Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 65 70 75 80 Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 85 90 95 Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly 100 105 110 Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu 115 120 125 Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 130 135 140 <210> 53 <211> 450 <212> ADN <213> Secuencia Artificial <220> <223> XTEN AE144-4A, secuencia de ADN <400> 53 ggcgcgccaa cgtccgaaag tgctacccct gagtcaggcc ctggtagtga gcctgccaca 60 agcggaagcg aaactccggg gacctcagag tctgccactc ccgaatcggg gccaggctct 120 gaaccggcca cttcagggag cgaaacacca ggaacatcgg agagcgctac cccggagagc 180 gggccaggaa ctagtactga gcctagcgag ggaagtgcac ctggtacaag cgagtccgcc 240 acacccgagt ctggccctgg ctctccagcg ggctcaccca cgagcactga agagggctct 300 cccgctggca gcccaacgtc gacagaagaa ggatcaccag caggctcccc cacatcaaca 360 gaggagggta catcagaatc tgctactccc gagagtggac ccggtacctc cactgagccc 420 agcgagggga gtgcaccagg tgcctcgagc 450 <210> 54 <211> 144 <212> PRT <213> Secuencia Artificial <220> <223> XTEN AE144-5A, secuencia de proteína <400> 54 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 1 5 10 15 Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 20 25 30 Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 35 40 45 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu 50 55 60 Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 65 70 75 80 Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 85 90 95 Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 100 105 110 Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 115 120 125 Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 130 135 140 <210> 55 <211> 450 <212> ADN <213> Secuencia Artificial <220> <223> XTEN AE144-5A, secuencia de ADN <400> 55 ggcgcgccaa catcagagag cgccacccct gaaagtggtc ccgggagcga gccagccaca 60 tctgggtcgg aaacgccagg cacaagtgag tctgcaactc ccgagtccgg acctggctcc 120 gagcctgcca ctagcggctc cgagactccg ggaacttccg agagcgctac accagaaagc 180 ggacccggaa ccagtaccga acctagcgag ggctctgctc cgggcagccc agccggctct 240 cctacatcca cggaggaggg cacttccgaa tccgccaccc cggagtcagg gccaggatct 300 gaacccgcta cctcaggcag tgagacgcca ggaacgagcg agtccgctac accggagagt 360 gggccaggga gccctgctgg atctcctacg tccactgagg aagggtcacc agcgggctcg 420 cccaccagca ctgaagaagg tgcctcgagc 450 <210> 56 <211> 144 <212> PRT <213> Secuencia Artificial <220> <223> XTEN AE144-6B, secuencia de proteína <400> 56 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser 1 5 10 15 Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 20 25 30 Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 35 40 45 Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 50 55 60 Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 65 70 75 80 Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 85 90 95 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro Ala 100 105 110 Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 115 120 125 Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 130 135 140 <210> 57 <211> 450 <212> ADN <213> Secuencia Artificial <220> <223> XTEN AE144-6B, secuencia de ADN <400> 57 ggcgcgccaa catctaccga gccttccgaa ggctctgccc ctgggacctc agaatctgca 60 acccctgaaa gcggccctgg aacctccgaa agtgccactc ccgagagcgg cccagggaca 120 agcgagtcag caacccctga gtctggaccc ggcagcgagc ctgcaacctc tggctcagag 180 actcccggct cagaacccgc tacctcaggc tccgagacac ccggctctcc tgctgggagt 240 cccacttcca ccgaggaagg aacatccact gagcctagtg agggctctgc ccctggaacc 300 agcacagagc caagtgaggg cagtgcacca ggatccgagc cagcaaccag cgggtccgag 360 actcccggga cctctgagtc tgccacccca gagagcggac ccggcacttc aaccgagccc 420 tccgaaggat cagcaccagg tgcctcgagc 450 <210> 58 <211> 144 <212> PRT <213> Secuencia Artificial <220> <223> XTEN AG144-1, secuencia de proteína <400> 58 Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser 1 5 10 15 Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Thr Pro Gly Ser Gly Thr 20 25 30 Ala Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser 35 40 45 Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser 50 55 60 Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr 65 70 75 80 Ala Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser 85 90 95 Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser 100 105 110 Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser 115 120 125 Ser Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser 130 135 140 <210> 59 <211> 450 <212> ADN <213> Secuencia Artificial <220> <223> XTEN AG144-1, secuencia de ADN <400> 59 ggcgcgccac ccgggtcgtc cccgtcggcg tccaccggaa cagggccagg gtcatccccg 60 tcagcgtcga ctgggacggg acccgggaca cccggttcgg ggactgcatc ctcctcgcct 120 ggttcgtcca ccccgtcagg agccacgggt tcgccgggaa gcagcccaag cgcatccact 180 ggtacagggc ctggggcttc accgggtact tcatccacgg ggtcaccggg aacgcccgga 240 tcggggacgg cttcctcatc accaggatcg tcaacaccct cgggcgcaac gggcagcccc 300 ggaacccctg gttcgggtac ggcgtcgtcg agccccggtg cgagcccggg aacaagctcg 360 acaggatcgc ctggggcgtc acccggcacg tcgagcacag gcagccccgg aacccctgga 420 tcgggaaccg cgtcgtcaag cgcctcgagc 450 <210> 60 <211> 144 <212> PRT <213> Secuencia Artificial <220> <223> XTEN AG144-A, secuencia de proteína <400> 60 Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Pro 1 5 10 15 Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser Thr 20 25 30 Gly Thr Gly Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 35 40 45 Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro 50 55 60 Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser 65 70 75 80 Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 85 90 95 Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Thr Pro Gly 100 105 110 Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 115 120 125 Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 130 135 140 <210> 61 <211> 450 <212> ADN <213> Secuencia Artificial <220> <223> XTEN AG144-A, secuencia de ADN <400> 61 ggcgcgccag gtgcctcgcc gggaacatca tcaactggtt cacccgggtc atccccctcg 60 gcctcaaccg ggacgggtcc cggctcatcc cccagcgcca gcactggaac aggtcctggc 120 actcctggtt ccggtacggc atcgtcatcc ccgggaagct caacaccgtc cggagcgaca 180 ggatcacctg gctcgtcacc ttcggcgtca actggaacgg ggccaggggc ctcacccgga 240 acgtcctcga ctgggtcgcc tggtacgccg ggatcaggaa cggcctcatc ctcgcctggg 300 tcctcaacgc cctcgggtgc gactggttcg ccgggaactc ctggctcggg gacggcctcg 360 tcgtcgcctg gggcatcacc ggggacgagc tccacggggt cccctggagc gtcaccgggg 420 acctcctcga caggtagccc ggcctcgagc 450 <210> 62 <211> 144 <212> PRT <213> Secuencia Artificial <220> <223> XTEN AG144-B, secuencia de proteína <400> 62 Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr 1 5 10 15 Pro Ser Gly Ala Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 20 25 30 Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 35 40 45 Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro 50 55 60 Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser Thr 65 70 75 80 Gly Thr Gly Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 85 90 95 Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ala Ser Pro 100 105 110 Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 115 120 125 Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 130 135 140 <210> 63 <211> 450 <212> ADN <213> Secuencia Artificial <220> <223> XTEN AG144-B, secuencia de ADN <400> 63 ggcgcgccag gtacaccggg cagcggcacg gcttcgtcgt cacccggctc gtccacaccg 60 tcgggagcta cgggaagccc aggagcgtca ccgggaacgt cgtcaacggg gtcaccgggt 120 acgccaggta gcggcacggc cagcagctcg ccaggttcat cgaccccgtc gggagcgact 180 gggtcgcccg gatcaagccc gtcagcttcc actggaacag gacccgggtc gtcgccgtca 240 gcctcaacgg ggacaggacc tggttcatcg acgccgtcag gggcgacagg ctcgcccgga 300 tcgtcaacac cctcgggggc aacggggagc cctggtgcgt cgcctggaac ctcatccacc 360 ggaagcccgg gggcctcgcc gggtacgagc tccacgggat cgcccggagc gtcccccgga 420 acttcaagca cagggagccc tgcctcgagc 450 <210> 64 <211> 144 <212> PRT <213> Secuencia Artificial <220> <223> XTEN AG144-C, secuencia de proteína <400> 64 Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro 1 5 10 15 Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 20 25 30 Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 35 40 45 Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Thr Pro Gly 50 55 60 Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 65 70 75 80 Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 85 90 95 Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Thr 100 105 110 Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 115 120 125 Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 130 135 140 <210> 65 <211> 450 <212> ADN <213> Secuencia Artificial <220> <223> XTEN AG144-C, secuencia de ADN <400> 65 ggcgcgccag gtacacccgg atcgggtaca gcgtcatcga gccccggtgc gtcacctggt 60 acgtcgagca cggggtcgcc aggggcgtcc cctgggacgt cctcaacagg ctcgcccggt 120 gcgtcacccg gcacgtcgtc cacgggttca cctggtagct ccccttccgc gtccactggc 180 accgggcctg gaactccggg gagcggcaca gcgagctcgt cgccgggagc atcgcctggg 240 acatcgagca ccgggtcgcc aggagcatcg cccggaacat ccagcacagg aagccccggc 300 gcgtcgcccg ggacatcaag cacaggttcc ccgggatcga gcacgccgtc cggagccact 360 ggatcaccag ggagctcgac accttccggc gcaacgggat cgcccggagc cagcccgggt 420 acgtcaagca ctggctcccc tgcctcgagc 450 <210> 66 <211> 144 <212> PRT <213> Secuencia Artificial <220> <223> XTEN AG144-F, secuencia de proteína <400> 66 Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro 1 5 10 15 Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser 20 25 30 Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 35 40 45 Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro 50 55 60 Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser 65 70 75 80 Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro 85 90 95 Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr 100 105 110 Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 115 120 125 Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 130 135 140 <210> 67 <211> 450 <212> ADN <213> Secuencia Artificial <220> <223> XTEN AG144-F, secuencia de ADN <400> 67 ggcgcgccag gctccagccc ctccgcgagc acgggaaccg gaccaggttc gtcaccctca 60 gcatcaacgg ggacgggacc gggggcgtca ccaggaacgt cctccaccgg ctcgccgggt 120 gcatcacccg gaacgtcatc gaccggatcg ccagggagct cgacgccatc aggcgcaaca 180 ggatcacctg gctcaagccc tagcgcgtca accggcacgg gtccgggtgc ctcccctggc 240 acgtccagca ccggatcacc cggatcgagc ccatccgcct caaccggaac cggacccggt 300 acaccagggt cgggaacagc ctcctcgtca ccaggctcct caaccccctc gggagccacg 360 ggttcgcccg gttcgtcaac gccttccgga gcaactggta gccccggagc atcgccagga 420 acttcgagca cggggtcgcc cgcctcgagc 450 <210> 68 <211> 4374 <212> ADN <213> Secuencia Artificial <220> <223> coFVIII-1 secuencia de ADN <400> 68 atgcagattg agctgtctac ttgctttttc ctgtgcctgc tgaggttttg cttttccgct 60 acacgaaggt attatctggg ggctgtggaa ctgtcttggg attacatgca gagtgacctg 120 ggagagctgc cagtggacgc aaggtttccc cctagagtcc ctaagtcatt ccccttcaac 180 actagcgtgg tctacaagaa aacactgttc gtggagttta ctgatcacct gttcaacatc 240 gcaaagccta ggccaccctg gatgggactg ctggggccaa caatccaggc cgaggtgtac 300 gacaccgtgg tcattacact taagaacatg gcctcacacc ccgtgagcct gcatgctgtg 360 ggcgtcagct actggaaggc ttccgaagga gcagagtatg acgatcagac ttcccagaga 420 gaaaaagagg acgataaggt gtttcctggc ggatctcata cctacgtgtg gcaggtcctg 480 aaagagaatg gccctatggc ctccgaccct ctgtgcctga cctactctta tctgagtcac 540 gtggacctgg tcaaggatct gaacagcggc ctgatcggag ccctgctggt gtgcagggaa 600 ggaagcctgg ctaaggagaa aacccagaca ctgcataagt tcattctgct gttcgccgtg 660 tttgacgaag ggaaatcatg gcacagcgag acaaagaata gtctgatgca ggacagggat 720 gccgcttcag ccagagcttg gcccaaaatg cacactgtga acggctacgt caatcgctca 780 ctgcctgggc tgatcggctg ccaccgaaag agcgtgtatt ggcatgtcat cgggatgggc 840 accacacctg aagtgcactc cattttcctg gagggacata cctttctggt ccgcaaccac 900 cgacaggctt ccctggagat ctctccaatt accttcctga cagcacagac tctgctgatg 960 gacctggggc agttcctgct gttttgccac atcagctccc accagcatga tggcatggag 1020 gcttacgtga aagtggactc ttgtcccgag gaacctcagc tgcggatgaa gaacaatgag 1080 gaagcagaag actatgacga tgacctgacc gactccgaga tggatgtggt ccgattcgat 1140 gacgataaca gcccctcctt tatccagatt agatctgtgg ccaagaaaca ccctaagaca 1200 tgggtccatt acatcgcagc cgaggaagag gactgggatt atgcaccact ggtgctggca 1260 ccagacgatc gctcctacaa atctcagtat ctgaacaatg ggccacagag gattggcaga 1320 aagtacaaga aagtgcggtt catggcatat accgatgaga ccttcaagac tcgcgaagcc 1380 atccagcacg agagcggcat cctgggacca ctgctgtacg gagaagtggg agacaccctg 1440 ctgatcattt tcaagaacca ggccagccgg ccttacaata tctatccaca tgggattaca 1500 gatgtgcgcc ctctgtacag caggagactg ccaaagggcg tcaaacacct gaaggacttc 1560 ccaatcctgc ccggagaaat cttcaagtac aagtggactg tcaccgtcga ggatggcccc 1620 actaagagcg accctcggtg cctgacccgc tactattcta gtttcgtgaa tatggaaaga 1680 gatctggcaa gcggactgat cggaccactg ctgatttgtt acaaagagag cgtggatcag 1740 agaggcaacc agatcatgtc cgacaagcgg aatgtgattc tgttcagtgt ctttgacgaa 1800 aacaggtcat ggtacctgac cgagaacatc cagagattcc tgcctaatcc agctggggtg 1860 cagctggaag atcctgagtt tcaggcatct aacatcatgc atagtattaa tggctacgtg 1920 ttcgacagtt tgcagctgag cgtgtgcctg cacgaggtcg cttactggta tatcctgagc 1980 attggggcac agacagattt cctgagcgtg ttcttttccg gctacacttt taagcataaa 2040 atggtctatg aggacacact gactctgttc cccttcagcg gcgaaaccgt gtttatgagc 2100 atggagaatc ccggactgtg gattctgggg tgccacaaca gcgatttcag aaatcgcgga 2160 atgactgccc tgctgaaagt gtcaagctgt gacaagaaca ccggggacta ctatgaagat 2220 tcatacgagg acatcagcgc atatctgctg tccaaaaaca atgccattga accccggtct 2280 tttagtcaga atcctccagt gctgaagagg caccagaggg agatcacccg cactaccctg 2340 cagagtgatc aggaagagat cgactacgac gatacaattt ctgtggaaat gaagaaagag 2400 gacttcgata tctatgacga agatgagaac cagagtcctc gatcattcca gaagaaaacc 2460 aggcattact ttattgccgc agtggagcgg ctgtgggatt atggcatgtc ctctagtcct 2520 cacgtgctgc gaaatagggc ccagtcagga agcgtcccac agttcaagaa agtggtcttc 2580 caggagttta cagacgggtc ctttactcag ccactgtaca ggggcgaact gaacgagcac 2640 ctgggactgc tggggcccta tatcagagca gaagtggagg ataacattat ggtcaccttc 2700 agaaatcagg cctctcggcc ttacagtttt tattcaagcc tgatctctta cgaagaggac 2760 cagcgacagg gagctgaacc acgaaaaaac ttcgtgaagc ctaatgagac caaaacatac 2820 ttttggaagg tgcagcacca tatggcccca acaaaagacg agttcgattg caaggcatgg 2880 gcctattttt ctgacgtgga tctggagaag gacgtgcaca gtggcctgat tggcccactg 2940 ctggtgtgcc atactaacac cctgaatcca gcccacggcc ggcaggtcac tgtccaggag 3000 ttcgctctgt tctttaccat ctttgatgag acaaagagct ggtacttcac cgaaaacatg 3060 gagcgaaatt gcagggctcc atgtaacatt cagatggaag accccacatt caaggagaac 3120 taccgctttc atgctatcaa tggatacatc atggatactc tgcccgggct ggtcatggca 3180 caggaccaga gaatccggtg gtatctgctg agcatgggca gcaacgagaa tatccactca 3240 attcatttca gcgggcacgt gtttactgtc aggaagaaag aagagtacaa gatggccctg 3300 tacaacctgt atcccggcgt gttcgaaacc gtcgagatgc tgcctagcaa ggccggaatc 3360 tggagagtgg aatgcctgat tggagagcac ctgcatgctg ggatgtctac cctgtttctg 3420 gtgtacagta ataagtgtca gacacccctg ggaatggcat ccgggcatat cagggatttc 3480 cagattaccg catctggaca gtacggacag tgggcaccta agctggctag actgcactat 3540 tccggatcta tcaacgcttg gtccacaaaa gagcctttct cttggattaa ggtggacctg 3600 ctggccccaa tgatcattca tggcatcaaa actcagggag ctcggcagaa gttctcctct 3660 ctgtacatct cacagtttat catcatgtac agcctggatg ggaagaaatg gcagacatac 3720 cgcggcaata gcacaggaac tctgatggtg ttctttggca acgtggacag cagcggaatc 3780 aagcacaaca ttttcaatcc ccctatcatt gctagataca tccggctgca cccaacccat 3840 tattctattc gaagtacact gaggatggaa ctgatgggat gcgatctgaa cagttgttca 3900 atgcccctgg ggatggagtc caaggcaatc tctgacgccc agattaccgc cagctcctac 3960 ttcactaata tgtttgctac ctggagccct tccaaagcaa gactgcacct gcaaggccgc 4020 agcaacgcat ggcgaccaca ggtgaacaat cccaaggagt ggttgcaggt cgattttcag 4080 aaaactatga aggtgaccgg ggtcacaact cagggcgtga aaagtctgct gacctcaatg 4140 tacgtcaagg agttcctgat ctctagttca caggacggac atcagtggac actgttcttt 4200 cagaacggga aggtgaaagt cttccagggc aatcaggatt cctttacacc tgtggtcaac 4260 agtctagacc ctccactgct gaccagatac ctgagaatcc accctcagtc ctgggtgcac 4320 cagattgccc tgagaatgga agtgctggga tgcgaggccc aggatctgta ctga 4374 <210> 69 <211> 577 <212> ADN <213> Secuencia Artificial <220> <223> Promotor ET, Secuencia de ADN <400> 69 ctcgaggtca attcacgcga gttaataatt accagcgcgg gccaaataaa taatccgcga 60 ggggcaggtg acgtttgccc agcgcgcgct ggtaattatt aacctcgcga atattgattc 120 gaggccgcga ttgccgcaat cgcgaggggc aggtgacctt tgcccagcgc gcgttcgccc 180 cgccccggac ggtatcgata agcttaggag cttgggctgc aggtcgaggg cactgggagg 240 atgttgagta agatggaaaa ctactgatga cccttgcaga gacagagtat taggacatgt 300 ttgaacaggg gccgggcgat cagcaggtag ctctagagga tccccgtctg tctgcacatt 360 tcgtagagcg agtgttccga tactctaatc tccctaggca aggttcatat ttgtgtaggt 420 tacttattct ccttttgttg actaagtcaa taatcagaat cagcaggttt ggagtcagct 480 tggcagggat cagcagcctg ggttggaagg agggggtata aaagcccctt caccaggaga 540 agccgtcaca cagatccaca agctcctgcc accatgg 577 <210> 70 <211> 4374 <212> ADN <213> Secuencia Artificial <220> <223> coFVIII-5 <400> 70 atgcaaatcg aactgagcac ctgtttcttc ctctgcctgc tgagattctg tttctccgcg 60 acccgccgat actacctggg agcagtggag ctctcctggg attacatgca gagcgacctt 120 ggggagctgc ccgtggatgc caggttccct ccccgggtgc caaagtcgtt tccgttcaac 180 acctccgtgg tgtacaagaa aactctgttc gtggagttca ccgaccacct gttcaatatc 240 gccaagccca gacctccctg gatggggctg ttgggaccta ccatccaagc ggaggtgtac 300 gacactgtgg tcatcactct gaagaacatg gcctcgcatc ccgtgtccct gcacgccgtg 360 ggagtgtctt actggaaagc gtccgagggg gccgaatacg acgaccagac ctcgcagaga 420 gaaaaggaag atgacaaggt gttcccagga ggatcgcaca cctacgtgtg gcaagtgttg 480 aaggagaacg gcccaatggc ctccgacccg ctgtgcctga cctactcgta cctgtcccac 540 gtggacctcg tgaaggacct caactcggga ctgattggag ccctgctggt ctgcagggaa 600 ggctcactgg cgaaagaaaa gactcagacc ttgcacaagt tcattctgct gttcgctgtg 660 ttcgacgagg ggaagtcgtg gcacagcgag actaagaact ccctgatgca agatagagat 720 gccgcctccg cccgggcctg gcctaagatg cacaccgtga acggttacgt gaaccgctcc 780 ctccctggcc tgattggatg ccaccggaag tccgtgtact ggcacgtgat cgggatgggg 840 accacccccg aggtgcacag catcttcctg gaaggtcaca catttctcgt gcgcaaccac 900 cggcaggcct ccctggaaat cagccccatt accttcctca ctgcccagac tctgctgatg 960 gacctgggac agttcctgct gttctgccat atctcctccc accaacatga cggaatggag 1020 gcatacgtga aggtcgattc ctgccctgag gaaccccagc tccgcatgaa gaacaatgag 1080 gaagccgagg actacgacga cgacctgacg gatagcgaga tggatgtggt ccggttcgat 1140 gacgataaca gcccttcctt catccaaatt cgctcggtgg caaagaagca ccccaagacc 1200 tgggtgcatt acattgcggc ggaagaagag gactgggatt atgccccgct tgtcctcgct 1260 cctgacgacc ggagctacaa gagccagtac ctgaacaacg gtccacagag gatcggtaga 1320 aagtacaaga aggtccgctt catggcctat accgacgaaa ccttcaaaac tagagaggcc 1380 atccaacacg aatccggcat cctgggcccg ctcttgtacg gagaagtcgg cgacaccctt 1440 ctcattatct tcaagaacca ggcttcccgg ccgtacaaca tctatccgca tgggatcact 1500 gacgtgcgcc cactgtactc gcggcgcctg cccaagggtg tcaaacacct gaaggatttt 1560 ccgatccttc cgggagaaat cttcaagtac aagtggaccg tgaccgtgga agatggccca 1620 actaagtctg accctagatg cctcacccgc tactactcat ccttcgtcaa catggagcgc 1680 gacctggcca gcggactgat cggcccgctg ctgatttgct acaaggaatc agtggaccaa 1740 cggggaaacc agatcatgtc ggataagagg aacgtcatcc tcttctccgt gtttgacgaa 1800 aaccggtcgt ggtacctgac tgaaaacatc cagcggttcc tccccaaccc cgcgggcgtg 1860 cagctggaag atcctgagtt tcaggcatca aacatcatgc actccattaa cggctacgtg 1920 ttcgattcgc tgcagctgag cgtgtgtctg cacgaagtgg cctactggta catcctgtcc 1980 attggtgccc agactgactt cctgtccgtg tttttctccg gctacacgtt caagcacaag 2040 atggtgtacg aggacaccct gaccctcttc cctttttccg gcgaaactgt gtttatgagc 2100 atggagaatc ccggcctgtg gatcttgggc tgccacaaca gcgacttccg taacagagga 2160 atgactgcgc tgctcaaggt gtccagctgc gacaagaaca ccggagacta ttatgaggac 2220 tcatacgagg acatctccgc ctacctcctg tccaagaata acgccattga acctcggagc 2280 ttcagccaga acccacccgt gcttaagaga catcaacggg agatcactag gaccaccctg 2340 cagtcagacc aggaggaaat cgactacgat gacaccatct cggtcgagat gaagaaggag 2400 gactttgaca tctacgacga agatgaaaac cagagcccga ggtcgttcca aaagaaaacc 2460 cgccactact ttattgctgc tgtcgagcgg ctgtgggact acggaatgtc gtcctcgccg 2520 cacgtgctcc gcaaccgagc ccagagcggc tcggtgccgc aattcaagaa ggtcgtgttc 2580 caggagttca ctgacgggag cttcactcag cctttgtacc ggggagaact caatgaacat 2640 ctcggcctcc tcggacctta catcagagca gaagtggaag ataacatcat ggtcactttc 2700 cgtaaccaag ccagccgccc gtactcgttc tactcctccc tcatttctta cgaagaggac 2760 cagcggcagg gcgcagaacc gcgcaagaac ttcgtgaagc ccaacgaaac caagacctac 2820 ttctggaaag tgcagcatca tatggccccg actaaggacg agtttgactg caaagcctgg 2880 gcctacttct ccgatgtgga cttggagaag gacgtccact ccggcctcat cggtcccctg 2940 ctcgtgtgcc ataccaatac cctgaacccc gcacacggtc gccaggtcac cgtgcaggag 3000 ttcgctctgt tcttcactat cttcgacgaa actaagtcct ggtacttcac cgagaacatg 3060 gagaggaact gcagagcccc ctgtaacatc cagatggagg acccgacgtt caaggaaaac 3120 taccggttcc acgccattaa cggatacatc atggatacgc tgccgggtct tgtgatggcc 3180 caggatcaac ggatcagatg gtacttattg tcgatgggca gcaacgagaa catccactct 3240 attcacttct ccggtcatgt gttcactgtg cggaagaagg aagagtacaa gatggccctg 3300 tacaaccttt atcccggagt gttcgaaact gtggaaatgc tgccgtcgaa ggccggcatt 3360 tggcgcgtgg agtgtttgat tggagaacat ctccatgcgg ggatgtcaac cctgttcctg 3420 gtgtatagca acaagtgcca gactccgctt gggatggcgt caggacacat tagggatttc 3480 cagatcactg cgtccggcca gtacggccaa tgggccccta agctggcccg cctgcattac 3540 tccggatcca ttaacgcctg gtcaaccaag gagccattct cctggatcaa ggtggacctt 3600 ctggccccca tgattatcca cggaattaag acccaggggg cccggcagaa gttctcctca 3660 ctgtacatca gccagttcat aatcatgtac tccctggacg gaaagaagtg gcaaacctac 3720 agggggaaca gcaccggcac actgatggtc tttttcggaa atgtggactc ctccgggatt 3780 aagcataaca tcttcaaccc tccgattatc gctcggtaca ttagacttca ccctacccac 3840 tacagcattc gctccaccct gcggatggaa ctgatgggct gcgatctgaa ctcgtgcagc 3900 atgccgttgg gaatggagtc caaagcaatt tccgacgcgc agatcaccgc ctcgtcctac 3960 tttaccaaca tgttcgccac gtggtcaccg tccaaggccc ggctgcacct ccagggaaga 4020 tccaacgcat ggcggccaca ggtcaacaac cctaaggagt ggctccaggt ggacttccag 4080 aaaaccatga aggtcaccgg agtcacaacc cagggagtga agtcgctgct gacttctatg 4140 tacgtcaagg agttcctgat ctccagcagc caggacgggc accagtggac cctgttcttc 4200 caaaatggaa aggtcaaggt gtttcagggc aatcaggatt cattcacccc ggtggtgaac 4260 tcccttgatc cacccctcct gacccgctac cttcgcatcc acccacagtc ctgggtgcac 4320 cagatcgcgc tgaggatgga ggtcctggga tgcgaagccc aggacctgta ctga 4374 <210> 71 <211> 4374 <212> ADN <213> Secuencia Artificial <220> <223> coFVIII-6 <400> 71 atgcagattg agctgtccac ttgtttcttc ctgtgcctcc tgcgcttctg tttctccgcc 60 actcgccggt actaccttgg agccgtggag ctttcatggg actacatgca gagcgacctg 120 ggcgaactcc ccgtggatgc cagattcccc ccccgcgtgc caaagtcctt cccctttaac 180 acctccgtgg tgtacaagaa aaccctcttt gtcgagttca ctgaccacct gttcaacatc 240 gccaagccgc gcccaccttg gatgggcctc ctgggaccga ccattcaagc tgaagtgtac 300 gacaccgtgg tgatcaccct gaagaacatg gcgtcccacc ccgtgtccct gcatgcggtc 360 ggagtgtcct actggaaggc ctccgaagga gctgagtacg acgaccagac tagccagcgg 420 gaaaaggagg acgataaagt gttcccgggc ggctcgcata cttacgtgtg gcaagtcctg 480 aaggaaaacg gacctatggc atccgatcct ctgtgcctga cttactccta cctttcccat 540 gtggacctcg tgaaggacct gaacagcggg ctgattggtg cacttctcgt gtgccgcgaa 600 ggttcgctcg ctaaggaaaa gacccagacc ctccataagt tcatcctttt gttcgctgtg 660 ttcgatgaag gaaagtcatg gcattccgaa actaagaact cgctgatgca ggaccgggat 720 gccgcctcag cccgcgcctg gcctaaaatg catacagtca acggatacgt gaatcggtca 780 ctgcccgggc tcatcggttg tcacagaaag tccgtgtact ggcacgtcat cggcatgggc 840 actacgcctg aagtgcactc catcttcctg gaagggcaca ccttcctcgt gcgcaaccac 900 cgccaggcct ctctggaaat ctccccgatt acctttctga ccgcccagac tctgctcatg 960 gacctggggc agttccttct cttctgccac atctccagcc atcagcacga cggaatggag 1020 gcctacgtga aggtggactc atgcccggaa gaacctcagt tgcggatgaa gaacaacgag 1080 gaggccgagg actatgacga cgatttgact gactccgaga tggacgtcgt gcggttcgat 1140 gacgacaaca gccccagctt catccagatt cgcagcgtgg ccaagaagca ccccaaaacc 1200 tgggtgcact acatcgcggc cgaggaagaa gattgggact acgccccgtt ggtgctggca 1260 cccgatgacc ggtcgtacaa gtcccagtat ctgaacaatg gtccgcagcg gattggcaga 1320 aagtacaaga aagtgcggtt catggcgtac actgacgaaa cgtttaagac ccgggaggcc 1380 attcaacatg agagcggcat tctgggacca ctgctgtacg gagaggtcgg cgataccctg 1440 ctcatcatct tcaaaaacca ggcctcccgg ccttacaaca tctaccctca cggaatcacc 1500 gacgtgcggc cactctactc gcggcgcctg ccgaagggcg tcaagcacct gaaagacttc 1560 cctatcctgc cgggcgaaat cttcaagtat aagtggaccg tcaccgtgga ggacgggccc 1620 accaagagcg atcctaggtg tctgactcgg tactactcca gcttcgtgaa catggaacgg 1680 gacctggcat cgggactcat tggaccgctg ctgatctgct acaaagagtc ggtggatcaa 1740 cgcggcaacc agatcatgtc cgacaagcgc aacgtgatcc tgttctccgt gtttgatgaa 1800 aacagatcct ggtacctcac tgaaaacatc cagaggttcc tcccaaaccc cgcaggagtg 1860 caactggagg accctgagtt tcaggcctcg aatatcatgc actcgattaa cggttacgtg 1920 ttcgactcgc tgcagctgag cgtgtgcctc catgaagtcg cttactggta cattctgtcc 1980 atcggcgccc agactgactt cctgagcgtg ttcttttccg gttacacctt taagcacaag 2040 atggtgtacg aagataccct gaccctgttc cctttctccg gcgaaacggt gttcatgtcg 2100 atggagaacc cgggtctgtg gattctggga tgccacaaca gcgactttcg gaaccgcgga 2160 atgactgccc tgctgaaggt gtcctcatgc gacaagaaca ccggagacta ctacgaggac 2220 tcctacgagg atatctcagc ctacctcctg tccaagaaca acgcgatcga gccgcgcagc 2280 ttcagccaga acccgcctgt gctgaagagg caccagcgag aaattacccg gaccaccctc 2340 caatcggatc aggaggaaat cgactacgac gacaccatct cggtggaaat gaagaaggaa 2400 gatttcgata tctacgacga ggacgaaaat cagtcccctc gctcattcca aaagaaaact 2460 agacactact ttatcgccgc ggtggaaaga ctgtgggact atggaatgtc atccagccct 2520 cacgtccttc ggaaccgggc ccagagcgga tcggtgcctc agttcaagaa agtggtgttc 2580 caggagttca ccgacggcag cttcacccag ccgctgtacc ggggagaact gaacgaacac 2640 ctgggcctgc tcggtcccta catccgcgcg gaagtggagg ataacatcat ggtgaccttc 2700 cgtaaccaag catccagacc ttactccttc tattcctccc tgatctcata cgaggaggac 2760 cagcgccaag gcgccgagcc ccgcaagaac ttcgtcaagc ccaacgagac taagacctac 2820 ttctggaagg tccaacacca tatggccccg accaaggatg agtttgactg caaggcctgg 2880 gcctacttct ccgacgtgga ccttgagaag gatgtccatt ccggcctgat cgggccgctg 2940 ctcgtgtgtc acaccaacac cctgaaccca gcgcatggac gccaggtcac cgtccaggag 3000 tttgctctgt tcttcaccat ttttgacgaa actaagtcct ggtacttcac cgagaatatg 3060 gagcgaaact gtagagcgcc ctgcaatatc cagatggaag atccgacttt caaggagaac 3120 tatagattcc acgccatcaa cgggtacatc atggatactc tgccggggct ggtcatggcc 3180 caggatcaga ggattcggtg gtacttgctg tcaatgggat cgaacgaaaa cattcactcc 3240 attcacttct ccggtcacgt gttcactgtg cgcaagaagg aggagtacaa gatggcgctg 3300 tacaatctgt accccggggt gttcgaaact gtggagatgc tgccgtccaa ggccggcatc 3360 tggagagtgg agtgcctgat cggagagcac ctccacgcgg ggatgtccac cctcttcctg 3420 gtgtactcga ataagtgcca gaccccgctg ggcatggcct cgggccacat cagagacttc 3480 cagatcacag caagcggaca atacggccaa tgggcgccga agctggcccg cttgcactac 3540 tccggatcga tcaacgcatg gtccaccaag gaaccgttct cgtggattaa ggtggacctc 3600 ctggccccta tgattatcca cggaattaag acccagggcg ccaggcagaa gttctcctcc 3660 ctgtacatct cgcaattcat catcatgtac agcctggacg ggaagaagtg gcagacttac 3720 aggggaaact ccaccggcac cctgatggtc tttttcggca acgtggattc ctccggcatt 3780 aagcacaaca tcttcaaccc accgatcata gccagatata ttaggctcca ccccactcac 3840 tactcaatcc gctcaactct tcggatggaa ctcatggggt gcgacctgaa ctcctgctcc 3900 atgccgttgg ggatggaatc aaaggctatt agcgacgccc agatcaccgc gagctcctac 3960 ttcactaaca tgttcgccac ctggagcccc tccaaggcca ggctgcactt gcagggacgg 4020 tcaaatgcct ggcggccgca agtgaacaat ccgaaggaat ggcttcaagt ggatttccaa 4080 aagaccatga aagtgaccgg agtcaccacc cagggagtga agtcccttct gacctcgatg 4140 tatgtgaagg agttcctgat tagcagcagc caggacgggc accagtggac cctgttcttc 4200 caaaacggaa aggtcaaggt gttccagggg aaccaggact cgttcacacc cgtggtgaac 4260 tccctggacc ccccactgct gacgcggtac ttgaggattc atcctcagtc ctgggtccat 4320 cagattgcat tgcgaatgga agtcctgggc tgcgaggccc aggacctgta ctga 4374 <210> 72 <211> 4824 <212> ADN <213> Secuencia Artificial <220> <223> coFVIII-6-XTEN <400> 72 atgcagattg agctgtccac ttgtttcttc ctgtgcctcc tgcgcttctg tttctccgcc 60 actcgccggt actaccttgg agccgtggag ctttcatggg actacatgca gagcgacctg 120 ggcgaactcc ccgtggatgc cagattcccc ccccgcgtgc caaagtcctt cccctttaac 180 acctccgtgg tgtacaagaa aaccctcttt gtcgagttca ctgaccacct gttcaacatc 240 gccaagccgc gcccaccttg gatgggcctc ctgggaccga ccattcaagc tgaagtgtac 300 gacaccgtgg tgatcaccct gaagaacatg gcgtcccacc ccgtgtccct gcatgcggtc 360 ggagtgtcct actggaaggc ctccgaagga gctgagtacg acgaccagac tagccagcgg 420 gaaaaggagg acgataaagt gttcccgggc ggctcgcata cttacgtgtg gcaagtcctg 480 aaggaaaacg gacctatggc atccgatcct ctgtgcctga cttactccta cctttcccat 540 gtggacctcg tgaaggacct gaacagcggg ctgattggtg cacttctcgt gtgccgcgaa 600 ggttcgctcg ctaaggaaaa gacccagacc ctccataagt tcatcctttt gttcgctgtg 660 ttcgatgaag gaaagtcatg gcattccgaa actaagaact cgctgatgca ggaccgggat 720 gccgcctcag cccgcgcctg gcctaaaatg catacagtca acggatacgt gaatcggtca 780 ctgcccgggc tcatcggttg tcacagaaag tccgtgtact ggcacgtcat cggcatgggc 840 actacgcctg aagtgcactc catcttcctg gaagggcaca ccttcctcgt gcgcaaccac 900 cgccaggcct ctctggaaat ctccccgatt acctttctga ccgcccagac tctgctcatg 960 gacctggggc agttccttct cttctgccac atctccagcc atcagcacga cggaatggag 1020 gcctacgtga aggtggactc atgcccggaa gaacctcagt tgcggatgaa gaacaacgag 1080 gaggccgagg actatgacga cgatttgact gactccgaga tggacgtcgt gcggttcgat 1140 gacgacaaca gccccagctt catccagatt cgcagcgtgg ccaagaagca ccccaaaacc 1200 tgggtgcact acatcgcggc cgaggaagaa gattgggact acgccccgtt ggtgctggca 1260 cccgatgacc ggtcgtacaa gtcccagtat ctgaacaatg gtccgcagcg gattggcaga 1320 aagtacaaga aagtgcggtt catggcgtac actgacgaaa cgtttaagac ccgggaggcc 1380 attcaacatg agagcggcat tctgggacca ctgctgtacg gagaggtcgg cgataccctg 1440 ctcatcatct tcaaaaacca ggcctcccgg ccttacaaca tctaccctca cggaatcacc 1500 gacgtgcggc cactctactc gcggcgcctg ccgaagggcg tcaagcacct gaaagacttc 1560 cctatcctgc cgggcgaaat cttcaagtat aagtggaccg tcaccgtgga ggacgggccc 1620 accaagagcg atcctaggtg tctgactcgg tactactcca gcttcgtgaa catggaacgg 1680 gacctggcat cgggactcat tggaccgctg ctgatctgct acaaagagtc ggtggatcaa 1740 cgcggcaacc agatcatgtc cgacaagcgc aacgtgatcc tgttctccgt gtttgatgaa 1800 aacagatcct ggtacctcac tgaaaacatc cagaggttcc tcccaaaccc cgcaggagtg 1860 caactggagg accctgagtt tcaggcctcg aatatcatgc actcgattaa cggttacgtg 1920 ttcgactcgc tgcagctgag cgtgtgcctc catgaagtcg cttactggta cattctgtcc 1980 atcggcgccc agactgactt cctgagcgtg ttcttttccg gttacacctt taagcacaag 2040 atggtgtacg aagataccct gaccctgttc cctttctccg gcgaaacggt gttcatgtcg 2100 atggagaacc cgggtctgtg gattctggga tgccacaaca gcgactttcg gaaccgcgga 2160 atgactgccc tgctgaaggt gtcctcatgc gacaagaaca ccggagacta ctacgaggac 2220 tcctacgagg atatctcagc ctacctcctg tccaagaaca acgcgatcga gccgcgcagc 2280 ttcagccaga acggcgcgcc aacatcagag agcgccaccc ctgaaagtgg tcccgggagc 2340 gagccagcca catctgggtc ggaaacgcca ggcacaagtg agtctgcaac tcccgagtcc 2400 ggacctggct ccgagcctgc cactagcggc tccgagactc cgggaacttc cgagagcgct 2460 acaccagaaa gcggacccgg aaccagtacc gaacctagcg agggctctgc tccgggcagc 2520 ccagccggct ctcctacatc cacggaggag ggcacttccg aatccgccac cccggagtca 2580 gggccaggat ctgaacccgc tacctcaggc agtgagacgc caggaacgag cgagtccgct 2640 acaccggaga gtgggccagg gagccctgct ggatctccta cgtccactga ggaagggtca 2700 ccagcgggct cgcccaccag cactgaagaa ggtgcctcga gcccgcctgt gctgaagagg 2760 caccagcgag aaattacccg gaccaccctc caatcggatc aggaggaaat cgactacgac 2820 gacaccatct cggtggaaat gaagaaggaa gatttcgata tctacgacga ggacgaaaat 2880 cagtcccctc gctcattcca aaagaaaact agacactact ttatcgccgc ggtggaaaga 2940 ctgtgggact atggaatgtc atccagccct cacgtccttc ggaaccgggc ccagagcgga 3000 tcggtgcctc agttcaagaa agtggtgttc caggagttca ccgacggcag cttcacccag 3060 ccgctgtacc ggggagaact gaacgaacac ctgggcctgc tcggtcccta catccgcgcg 3120 gaagtggagg ataacatcat ggtgaccttc cgtaaccaag catccagacc ttactccttc 3180 tattcctccc tgatctcata cgaggaggac cagcgccaag gcgccgagcc ccgcaagaac 3240 ttcgtcaagc ccaacgagac taagacctac ttctggaagg tccaacacca tatggccccg 3300 accaaggatg agtttgactg caaggcctgg gcctacttct ccgacgtgga ccttgagaag 3360 gatgtccatt ccggcctgat cgggccgctg ctcgtgtgtc acaccaacac cctgaaccca 3420 gcgcatggac gccaggtcac cgtccaggag tttgctctgt tcttcaccat ttttgacgaa 3480 actaagtcct ggtacttcac cgagaatatg gagcgaaact gtagagcgcc ctgcaatatc 3540 cagatggaag atccgacttt caaggagaac tatagattcc acgccatcaa cgggtacatc 3600 atggatactc tgccggggct ggtcatggcc caggatcaga ggattcggtg gtacttgctg 3660 tcaatgggat cgaacgaaaa cattcactcc attcacttct ccggtcacgt gttcactgtg 3720 cgcaagaagg aggagtacaa gatggcgctg tacaatctgt accccggggt gttcgaaact 3780 gtggagatgc tgccgtccaa ggccggcatc tggagagtgg agtgcctgat cggagagcac 3840 ctccacgcgg ggatgtccac cctcttcctg gtgtactcga ataagtgcca gaccccgctg 3900 ggcatggcct cgggccacat cagagacttc cagatcacag caagcggaca atacggccaa 3960 tgggcgccga agctggcccg cttgcactac tccggatcga tcaacgcatg gtccaccaag 4020 gaaccgttct cgtggattaa ggtggacctc ctggccccta tgattatcca cggaattaag 4080 acccagggcg ccaggcagaa gttctcctcc ctgtacatct cgcaattcat catcatgtac 4140 agcctggacg ggaagaagtg gcagacttac aggggaaact ccaccggcac cctgatggtc 4200 tttttcggca acgtggattc ctccggcatt aagcacaaca tcttcaaccc accgatcata 4260 gccagatata ttaggctcca ccccactcac tactcaatcc gctcaactct tcggatggaa 4320 ctcatggggt gcgacctgaa ctcctgctcc atgccgttgg ggatggaatc aaaggctatt 4380 agcgacgccc agatcaccgc gagctcctac ttcactaaca tgttcgccac ctggagcccc 4440 tccaaggcca ggctgcactt gcagggacgg tcaaatgcct ggcggccgca agtgaacaat 4500 ccgaaggaat ggcttcaagt ggatttccaa aagaccatga aagtgaccgg agtcaccacc 4560 cagggagtga agtcccttct gacctcgatg tatgtgaagg agttcctgat tagcagcagc 4620 caggacgggc accagtggac cctgttcttc caaaacggaa aggtcaaggt gttccagggg 4680 aaccaggact cgttcacacc cgtggtgaac tccctggacc ccccactgct gacgcggtac 4740 ttgaggattc atcctcagtc ctgggtccat cagattgcat tgcgaatgga agtcctgggc 4800 tgcgaggccc aggacctgta ctga 4824 <210> 73 <211> 12 <212> PRT <213> Secuencia Artificial <220> <223> Motivo AD <400> 73 Gly Glu Ser Pro Gly Gly Ser Ser Gly Ser Glu Ser 1 5 10 <210> 74 <211> 12 <212> PRT <213> Secuencia Artificial <220> <223> Motivo AD <400> 74 Gly Ser Glu Gly Ser Ser Gly Pro Gly Glu Ser Ser 1 5 10 <210> 75 <211> 12 <212> PRT <213> Secuencia Artificial <220> <223> Motivo AD <400> 75 Gly Ser Ser Glu Ser Gly Ser Ser Glu Gly Gly Pro 1 5 10 <210> 76 <211> 12 <212> PRT <213> Secuencia Artificial <220> <223> Motivo AD <400> 76 Gly Ser Gly Gly Glu Pro Ser Glu Ser Gly Ser Ser 1 5 10 <210> 77 <211> 12 <212> PRT <213> Secuencia Artificial <220> <223> Motivo AE, AM <400> 77 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 1 5 10 <210> 78 <211> 12 <212> PRT <213> Secuencia Artificial <220> <223> Motivo AE, AM, AQ <400> 78 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 1 5 10 <210> 79 <211> 12 <212> PRT <213> Secuencia Artificial <220> <223> Motivo AE, AM, AQ <400> 79 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 1 5 10 <210> 80 <211> 12 <212> PRT <213> Secuencia Artificial <220> <223> Motivo AE, AM, AQ <400> 80 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 1 5 10 <210> 81 <211> 12 <212> PRT <213> Secuencia Artificial <220> <223> Motivo AF, AM <400> 81 Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro 1 5 10 <210> 82 <211> 12 <212> PRT <213> Secuencia Artificial <220> <223> Motivo AF, AM <400> 82 Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro 1 5 10 <210> 83 <211> 12 <212> PRT <213> Secuencia Artificial <220> <223> Motivo AF, AM <400> 83 Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro 1 5 10 <210> 84 <211> 12 <212> PRT <213> Secuencia Artificial <220> <223> Motivo AF, AM <400> 84 Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro 1 5 10 <210> 85 <211> 12 <212> PRT <213> Secuencia Artificial <220> <223> Motivo AG, AM <400> 85 Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 1 5 10 <210> 86 <211> 12 <212> PRT <213> Secuencia Artificial <220> <223> Motivo AG, AM <400> 86 Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 1 5 10 <210> 87 <211> 12 <212> PRT <213> Secuencia Artificial <220> <223> Motivo AG, AM <400> 87 Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro 1 5 10 <210> 88 <211> 12 <212> PRT <213> Secuencia Artificial <220> <223> Motivo AG, AM <400> 88 Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 1 5 10 <210> 89 <211> 12 <212> PRT <213> Secuencia Artificial <220> <223> Motivo AQ <400> 89 Gly Glu Pro Ala Gly Ser Pro Thr Ser Thr Ser Glu 1 5 10 <210> 90 <211> 12 <212> PRT <213> Secuencia Artificial <220> <223> Motivo AQ <400> 90 Gly Thr Gly Glu Pro Ser Ser Thr Pro Ala Ser Glu 1 5 10 <210> 91 <211> 12 <212> PRT <213> Secuencia Artificial <220> <223> Motivo AQ <400> 91 Gly Ser Gly Pro Ser Thr Glu Ser Ala Pro Thr Glu 1 5 10 <210> 92 <211> 12 <212> PRT <213> Secuencia Artificial <220> <223> Motivo AQ <400> 92 Gly Ser Glu Thr Pro Ser Gly Pro Ser Glu Thr Ala 1 5 10 <210> 93 <211> 12 <212> PRT <213> Secuencia Artificial <220> <223> Motivo AQ <400> 93 Gly Pro Ser Glu Thr Ser Thr Ser Glu Pro Gly Ala 1 5 10 <210> 94 <211> 12 <212> PRT <213> Secuencia Artificial <220> <223> Motivo AQ <400> 94 Gly Ser Pro Ser Glu Pro Thr Glu Gly Thr Ser Ala 1 5 10 <210> 95 <211> 12 <212> PRT <213> Secuencia Artificial <220> <223> Motivo BC <400> 95 Gly Ser Gly Ala Ser Glu Pro Thr Ser Thr Glu Pro 1 5 10 <210> 96 <211> 12 <212> PRT <213> Secuencia Artificial <220> <223> Motivo BC <400> 96 Gly Ser Glu Pro Ala Thr Ser Gly Thr Glu Pro Ser 1 5 10 <210> 97 <211> 12 <212> PRT <213> Secuencia Artificial <220> <223> Motivo BC <400> 97 Gly Thr Ser Glu Pro Ser Thr Ser Glu Pro Gly Ala 1 5 10 <210> 98 <211> 12 <212> PRT <213> Secuencia Artificial <220> <223> Motivo BC <400> 98 Gly Thr Ser Thr Glu Pro Ser Glu Pro Gly Ser Ala 1 5 10 <210> 99 <211> 12 <212> PRT <213> Secuencia Artificial <220> <223> Motivo BD <400> 99 Gly Ser Thr Ala Gly Ser Glu Thr Ser Thr Glu Ala 1 5 10 <210> 100 <211> 12 <212> PRT <213> Secuencia Artificial <220> <223> Motivo BD <400> 100 Gly Ser Glu Thr Ala Thr Ser Gly Ser Glu Thr Ala 1 5 10 <210> 101 <211> 12 <212> PRT <213> Secuencia Artificial <220> <223> Motivo BD <400> 101 Gly Thr Ser Glu Ser Ala Thr Ser Glu Ser Gly Ala 1 5 10 <210> 102 <211> 12 <212> PRT <213> Secuencia Artificial <220> <223> Motivo BD <400> 102 Gly Thr Ser Thr Glu Ala Ser Glu Gly Ser Ala Ser 1 5 10 <210> 103 <211> 1607 <212> PRT <213> Secuencia Artificial <220> <223> Secuencia de Proteína coFVIII-6-XTEN <400> 103 Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 1 5 10 15 Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 20 25 30 Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 35 40 45 Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 50 55 60 Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 65 70 75 80 Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 85 90 95 Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 100 105 110 His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 115 120 125 Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 130 135 140 Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 145 150 155 160 Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 165 170 175 Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 180 185 190 Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 195 200 205 Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 210 215 220 Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 225 230 235 240 Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 245 250 255 Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 260 265 270 Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 275 280 285 Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 290 295 300 Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 305 310 315 320 Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 325 330 335 Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 340 345 350 Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 355 360 365 Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 370 375 380 Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 385 390 395 400 Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 405 410 415 Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 420 425 430 Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 435 440 445 Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 450 455 460 Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 465 470 475 480 Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 485 490 495 His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 500 505 510 Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 515 520 525 Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 530 535 540 Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 545 550 555 560 Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 565 570 575 Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 580 585 590 Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 595 600 605 Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 610 615 620 Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 625 630 635 640 Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 645 650 655 Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 660 665 670 Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 675 680 685 Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 690 695 700 Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 705 710 715 720 Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 725 730 735 Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 740 745 750 Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Gly Ala Pro Thr 755 760 765 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr 770 775 780 Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 785 790 795 800 Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 805 810 815 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro 820 825 830 Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 835 840 845 Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser 850 855 860 Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala 865 870 875 880 Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 885 890 895 Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ala 900 905 910 Ser Ser Pro Pro Val Leu Lys Arg His Gln Arg Glu Ile Thr Arg Thr 915 920 925 Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser 930 935 940 Val Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn 945 950 955 960 Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr Phe Ile Ala 965 970 975 Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser Ser Pro His Val 980 985 990 Leu Arg Asn Arg Ala Gln Ser Gly Ser Val Pro Gln Phe Lys Lys Val 995 1000 1005 Val Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln Pro Leu Tyr 1010 1015 1020 Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu Gly Pro Tyr Ile 1025 1030 1035 Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg Asn Gln 1040 1045 1050 Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu 1055 1060 1065 Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val Lys 1070 1075 1080 Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His Met 1085 1090 1095 Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe 1100 1105 1110 Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly 1115 1120 1125 Pro Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His Gly 1130 1135 1140 Arg Gln Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe 1145 1150 1155 Asp Glu Thr Lys Ser Trp Tyr Phe Thr Glu Asn Met Glu Arg Asn 1160 1165 1170 Cys Arg Ala Pro Cys Asn Ile Gln Met Glu Asp Pro Thr Phe Lys 1175 1180 1185 Glu Asn Tyr Arg Phe His Ala Ile Asn Gly Tyr Ile Met Asp Thr 1190 1195 1200 Leu Pro Gly Leu Val Met Ala Gln Asp Gln Arg Ile Arg Trp Tyr 1205 1210 1215 Leu Leu Ser Met Gly Ser Asn Glu Asn Ile His Ser Ile His Phe 1220 1225 1230 Ser Gly His Val Phe Thr Val Arg Lys Lys Glu Glu Tyr Lys Met 1235 1240 1245 Ala Leu Tyr Asn Leu Tyr Pro Gly Val Phe Glu Thr Val Glu Met 1250 1255 1260 Leu Pro Ser Lys Ala Gly Ile Trp Arg Val Glu Cys Leu Ile Gly 1265 1270 1275 Glu His Leu His Ala Gly Met Ser Thr Leu Phe Leu Val Tyr Ser 1280 1285 1290 Asn Lys Cys Gln Thr Pro Leu Gly Met Ala Ser Gly His Ile Arg 1295 1300 1305 Asp Phe Gln Ile Thr Ala Ser Gly Gln Tyr Gly Gln Trp Ala Pro 1310 1315 1320 Lys Leu Ala Arg Leu His Tyr Ser Gly Ser Ile Asn Ala Trp Ser 1325 1330 1335 Thr Lys Glu Pro Phe Ser Trp Ile Lys Val Asp Leu Leu Ala Pro 1340 1345 1350 Met Ile Ile His Gly Ile Lys Thr Gln Gly Ala Arg Gln Lys Phe 1355 1360 1365 Ser Ser Leu Tyr Ile Ser Gln Phe Ile Ile Met Tyr Ser Leu Asp 1370 1375 1380 Gly Lys Lys Trp Gln Thr Tyr Arg Gly Asn Ser Thr Gly Thr Leu 1385 1390 1395 Met Val Phe Phe Gly Asn Val Asp Ser Ser Gly Ile Lys His Asn 1400 1405 1410 Ile Phe Asn Pro Pro Ile Ile Ala Arg Tyr Ile Arg Leu His Pro 1415 1420 1425 Thr His Tyr Ser Ile Arg Ser Thr Leu Arg Met Glu Leu Met Gly 1430 1435 1440 Cys Asp Leu Asn Ser Cys Ser Met Pro Leu Gly Met Glu Ser Lys 1445 1450 1455 Ala Ile Ser Asp Ala Gln Ile Thr Ala Ser Ser Tyr Phe Thr Asn 1460 1465 1470 Met Phe Ala Thr Trp Ser Pro Ser Lys Ala Arg Leu His Leu Gln 1475 1480 1485 Gly Arg Ser Asn Ala Trp Arg Pro Gln Val Asn Asn Pro Lys Glu 1490 1495 1500 Trp Leu Gln Val Asp Phe Gln Lys Thr Met Lys Val Thr Gly Val 1505 1510 1515 Thr Thr Gln Gly Val Lys Ser Leu Leu Thr Ser Met Tyr Val Lys 1520 1525 1530 Glu Phe Leu Ile Ser Ser Ser Gln Asp Gly His Gln Trp Thr Leu 1535 1540 1545 Phe Phe Gln Asn Gly Lys Val Lys Val Phe Gln Gly Asn Gln Asp 1550 1555 1560 Ser Phe Thr Pro Val Val Asn Ser Leu Asp Pro Pro Leu Leu Thr 1565 1570 1575 Arg Tyr Leu Arg Ile His Pro Gln Ser Trp Val His Gln Ile Ala 1580 1585 1590 Leu Arg Met Glu Val Leu Gly Cys Glu Ala Gln Asp Leu Tyr 1595 1600 1605 <210> 104 <211> 16 <212> ADN <213> Secuencia Artificial <220> <223> Sitio de unión a Rep (RBS) para AAV2 <400> 104 gcgcgctcgc tcgctc 16 <210> 105 <211> 6 <212> ADN <213> Secuencia Artificial <220> <223> Sitio de resolucoón terminal (TRS) para AAV2 <400> 105 agttgg 6 <210> 106 <211> 2328 <212> PRT <213> Secuencia Artificial <220> <223> FVIII de longitud completa maduro <400> 106 Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 1 5 10 15 Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 20 25 30 Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 35 40 45 Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 50 55 60 Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 65 70 75 80 Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 85 90 95 Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 100 105 110 Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 115 120 125 Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 130 135 140 Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 145 150 155 160 His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 165 170 175 Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 180 185 190 His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 195 200 205 His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 210 215 220 Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 225 230 235 240 Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 245 250 255 Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 260 265 270 Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 275 280 285 Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 290 295 300 Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 305 310 315 320 Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 325 330 335 Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 340 345 350 Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 355 360 365 Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 370 375 380 Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 385 390 395 400 Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 405 410 415 Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 420 425 430 Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 435 440 445 Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 450 455 460 Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 465 470 475 480 Thr Asp Val Arg Pro Lys Arg Arg Leu Pro Lys Gly Val Lys His Leu 485 490 495 Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys Trp Thr 500 505 510 Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr 515 520 525 Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala Ser Gly 530 535 540 Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp Gln Arg 545 550 555 560 Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe Ser Val 565 570 575 Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln Arg Phe 580 585 590 Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe Gln Ala 595 600 605 Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu Gln 610 615 620 Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu Ser Ile 625 630 635 640 Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr Phe 645 650 655 Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe Ser 660 665 670 Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp Ile Leu 675 680 685 Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala Leu Leu 690 695 700 Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu Asp Ser 705 710 715 720 Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala Ile Glu 725 730 735 Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys 740 745 750 Gln Phe Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp 755 760 765 Pro Trp Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser 770 775 780 Ser Ser Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly 785 790 795 800 Leu Ser Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp 805 810 815 Asp Pro Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met 820 825 830 Thr His Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr 835 840 845 Pro Glu Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr 850 855 860 Ala Ala Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser 865 870 875 880 Asn Asn Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr 885 890 895 Asp Asn Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp 900 905 910 Ser Gln Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr 915 920 925 Glu Ser Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys 930 935 940 Leu Leu Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys 945 950 955 960 Asn Val Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys Arg Ala 965 970 975 His Gly Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys Val Ser 980 985 990 Ile Ser Leu Leu Lys Thr Asn Lys Thr Ser Asn Asn Ser Ala Thr Asn 995 1000 1005 Arg Lys Thr His Ile Asp Gly Pro Ser Leu Leu Ile Glu Asn Ser 1010 1015 1020 Pro Ser Val Trp Gln Asn Ile Ser Asp Thr Glu Phe Lys Lys Val 1025 1030 1035 Thr Pro Leu Ile His Asp Arg Met Leu Met Asp Lys Asn Ala Thr 1040 1045 1050 Ala Leu Arg Leu Asn His Met Ser Asn Lys Thr Thr Ser Ser Lys 1055 1060 1065 Asn Met Glu Met Val Gln Gln Lys Lys Glu Gly Pro Ile Pro Pro 1070 1075 1080 Asp Ala Gln Asn Pro Asp Met Ser Phe Phe Lys Met Leu Phe Leu 1085 1090 1095 Pro Glu Ser Ala Arg Trp Ile Gln Arg Thr His Gly Lys Asn Ser 1100 1105 1110 Leu Asn Ser Gly Gln Gly Pro Ser Pro Lys Gln Leu Val Ser Leu 1115 1120 1125 Gly Pro Glu Lys Ser Val Glu Gly Gln Asn Phe Leu Ser Glu Lys 1130 1135 1140 Asn Lys Val Val Val Gly Lys Gly Glu Phe Thr Lys Asp Val Gly 1145 1150 1155 Leu Lys Glu Met Val Phe Pro Ser Ser Arg Asn Leu Phe Leu Thr 1160 1165 1170 Asn Leu Asp Asn Leu His Glu Asn Asn Thr His Asn Gln Glu Lys 1175 1180 1185 Lys Ile Gln Glu Glu Ile Glu Lys Lys Glu Thr Leu Ile Gln Glu 1190 1195 1200 Asn Val Val Leu Pro Gln Ile His Thr Val Thr Gly Thr Lys Asn 1205 1210 1215 Phe Met Lys Asn Leu Phe Leu Leu Ser Thr Arg Gln Asn Val Glu 1220 1225 1230 Gly Ser Tyr Asp Gly Ala Tyr Ala Pro Val Leu Gln Asp Phe Arg 1235 1240 1245 Ser Leu Asn Asp Ser Thr Asn Arg Thr Lys Lys His Thr Ala His 1250 1255 1260 Phe Ser Lys Lys Gly Glu Glu Glu Asn Leu Glu Gly Leu Gly Asn 1265 1270 1275 Gln Thr Lys Gln Ile Val Glu Lys Tyr Ala Cys Thr Thr Arg Ile 1280 1285 1290 Ser Pro Asn Thr Ser Gln Gln Asn Phe Val Thr Gln Arg Ser Lys 1295 1300 1305 Arg Ala Leu Lys Gln Phe Arg Leu Pro Leu Glu Glu Thr Glu Leu 1310 1315 1320 Glu Lys Arg Ile Ile Val Asp Asp Thr Ser Thr Gln Trp Ser Lys 1325 1330 1335 Asn Met Lys His Leu Thr Pro Ser Thr Leu Thr Gln Ile Asp Tyr 1340 1345 1350 Asn Glu Lys Glu Lys Gly Ala Ile Thr Gln Ser Pro Leu Ser Asp 1355 1360 1365 Cys Leu Thr Arg Ser His Ser Ile Pro Gln Ala Asn Arg Ser Pro 1370 1375 1380 Leu Pro Ile Ala Lys Val Ser Ser Phe Pro Ser Ile Arg Pro Ile 1385 1390 1395 Tyr Leu Thr Arg Val Leu Phe Gln Asp Asn Ser Ser His Leu Pro 1400 1405 1410 Ala Ala Ser Tyr Arg Lys Lys Asp Ser Gly Val Gln Glu Ser Ser 1415 1420 1425 His Phe Leu Gln Gly Ala Lys Lys Asn Asn Leu Ser Leu Ala Ile 1430 1435 1440 Leu Thr Leu Glu Met Thr Gly Asp Gln Arg Glu Val Gly Ser Leu 1445 1450 1455 Gly Thr Ser Ala Thr Asn Ser Val Thr Tyr Lys Lys Val Glu Asn 1460 1465 1470 Thr Val Leu Pro Lys Pro Asp Leu Pro Lys Thr Ser Gly Lys Val 1475 1480 1485 Glu Leu Leu Pro Lys Val His Ile Tyr Gln Lys Asp Leu Phe Pro 1490 1495 1500 Thr Glu Thr Ser Asn Gly Ser Pro Gly His Leu Asp Leu Val Glu 1505 1510 1515 Gly Ser Leu Leu Gln Gly Thr Glu Gly Ala Ile Lys Trp Asn Glu 1520 1525 1530 Ala Asn Arg Pro Gly Lys Val Pro Phe Leu Arg Val Ala Thr Glu 1535 1540 1545 Ser Ser Ala Lys Thr Pro Ser Lys Leu Leu Asp Pro Leu Ala Trp 1550 1555 1560 Asp Asn His Tyr Gly Thr Gln Ile Pro Lys Glu Glu Trp Lys Ser 1565 1570 1575 Gln Glu Lys Ser Pro Glu Lys Thr Ala Phe Lys Lys Lys Asp Thr 1580 1585 1590 Ile Leu Ser Leu Asn Ala Cys Glu Ser Asn His Ala Ile Ala Ala 1595 1600 1605 Ile Asn Glu Gly Gln Asn Lys Pro Glu Ile Glu Val Thr Trp Ala 1610 1615 1620 Lys Gln Gly Arg Thr Glu Arg Leu Cys Ser Gln Asn Pro Pro Val 1625 1630 1635 Leu Lys Arg His Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser 1640 1645 1650 Asp Gln Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser Val Glu Met 1655 1660 1665 Lys Lys Glu Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn Gln Ser 1670 1675 1680 Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr Phe Ile Ala Ala 1685 1690 1695 Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser Ser Pro His Val 1700 1705 1710 Leu Arg Asn Arg Ala Gln Ser Gly Ser Val Pro Gln Phe Lys Lys 1715 1720 1725 Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln Pro Leu 1730 1735 1740 Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu Gly Pro Tyr 1745 1750 1755 Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg Asn 1760 1765 1770 Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr 1775 1780 1785 Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val 1790 1795 1800 Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His 1805 1810 1815 Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr 1820 1825 1830 Phe Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile 1835 1840 1845 Gly Pro Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His 1850 1855 1860 Gly Arg Gln Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile 1865 1870 1875 Phe Asp Glu Thr Lys Ser Trp Tyr Phe Thr Glu Asn Met Glu Arg 1880 1885 1890 Asn Cys Arg Ala Pro Cys Asn Ile Gln Met Glu Asp Pro Thr Phe 1895 1900 1905 Lys Glu Asn Tyr Arg Phe His Ala Ile Asn Gly Tyr Ile Met Asp 1910 1915 1920 Thr Leu Pro Gly Leu Val Met Ala Gln Asp Gln Arg Ile Arg Trp 1925 1930 1935 Tyr Leu Leu Ser Met Gly Ser Asn Glu Asn Ile His Ser Ile His 1940 1945 1950 Phe Ser Gly His Val Phe Thr Val Arg Lys Lys Glu Glu Tyr Lys 1955 1960 1965 Met Ala Leu Tyr Asn Leu Tyr Pro Gly Val Phe Glu Thr Val Glu 1970 1975 1980 Met Leu Pro Ser Lys Ala Gly Ile Trp Arg Val Glu Cys Leu Ile 1985 1990 1995 Gly Glu His Leu His Ala Gly Met Ser Thr Leu Phe Leu Val Tyr 2000 2005 2010 Ser Asn Lys Cys Gln Thr Pro Leu Gly Met Ala Ser Gly His Ile 2015 2020 2025 Arg Asp Phe Gln Ile Thr Ala Ser Gly Gln Tyr Gly Gln Trp Ala 2030 2035 2040 Pro Lys Leu Ala Arg Leu His Tyr Ser Gly Ser Ile Asn Ala Trp 2045 2050 2055 Ser Thr Lys Glu Pro Phe Ser Trp Ile Lys Val Asp Leu Leu Ala 2060 2065 2070 Pro Met Ile Ile His Gly Ile Lys Thr Gln Gly Ala Arg Gln Lys 2075 2080 2085 Phe Ser Ser Leu Tyr Ile Ser Gln Phe Ile Ile Met Tyr Ser Leu 2090 2095 2100 Asp Gly Lys Lys Trp Gln Thr Tyr Arg Gly Asn Ser Thr Gly Thr 2105 2110 2115 Leu Met Val Phe Phe Gly Asn Val Asp Ser Ser Gly Ile Lys His 2120 2125 2130 Asn Ile Phe Asn Pro Pro Ile Ile Ala Arg Tyr Ile Arg Leu His 2135 2140 2145 Pro Thr His Tyr Ser Ile Arg Ser Thr Leu Arg Met Glu Leu Met 2150 2155 2160 Gly Cys Asp Leu Asn Ser Cys Ser Met Pro Leu Gly Met Glu Ser 2165 2170 2175 Lys Ala Ile Ser Asp Ala Gln Ile Thr Ala Ser Ser Tyr Phe Thr 2180 2185 2190 Asn Met Phe Ala Thr Trp Ser Pro Ser Lys Ala Arg Leu His Leu 2195 2200 2205 Gln Gly Arg Ser Asn Ala Trp Arg Pro Gln Val Asn Asn Pro Lys 2210 2215 2220 Glu Trp Leu Gln Val Asp Phe Gln Lys Thr Met Lys Val Thr Gly 2225 2230 2235 Val Thr Thr Gln Gly Val Lys Ser Leu Leu Thr Ser Met Tyr Val 2240 2245 2250 Lys Glu Phe Leu Ile Ser Ser Ser Gln Asp Gly His Gln Trp Thr 2255 2260 2265 Leu Phe Phe Gln Asn Gly Lys Val Lys Val Phe Gln Gly Asn Gln 2270 2275 2280 Asp Ser Phe Thr Pro Val Val Asn Ser Leu Asp Pro Pro Leu Leu 2285 2290 2295 Thr Arg Tyr Leu Arg Ile His Pro Gln Ser Trp Val His Gln Ile 2300 2305 2310 Ala Leu Arg Met Glu Val Leu Gly Cys Glu Ala Gln Asp Leu Tyr 2315 2320 2325 <210> 107 <211> 7053 <212> ADN <213> Secuencia Artificial <220> <223> FVIII de longitud completa maduro <400> 107 atgcaaatag agctctccac ctgcttcttt ctgtgccttt tgcgattctg ctttagtgcc 60 accagaagat actacctggg tgcagtggaa ctgtcatggg actatatgca aagtgatctc 120 ggtgagctgc ctgtggacgc aagatttcct cctagagtgc caaaatcttt tccattcaac 180 acctcagtcg tgtacaaaaa gactctgttt gtagaattca cggatcacct tttcaacatc 240 gctaagccaa ggccaccctg gatgggtctg ctaggtccta ccatccaggc tgaggtttat 300 gatacagtgg tcattacact taagaacatg gcttcccatc ctgtcagtct tcatgctgtt 360 ggtgtatcct actggaaagc ttctgaggga gctgaatatg atgatcagac cagtcaaagg 420 gagaaagaag atgataaagt cttccctggt ggaagccata catatgtctg gcaggtcctg 480 aaagagaatg gtccaatggc ctctgaccca ctgtgcctta cctactcata tctttctcat 540 gtggacctgg taaaagactt gaattcaggc ctcattggag ccctactagt atgtagagaa 600 gggagtctgg ccaaggaaaa gacacagacc ttgcacaaat ttatactact ttttgctgta 660 tttgatgaag ggaaaagttg gcactcagaa acaaagaact ccttgatgca ggatagggat 720 gctgcatctg ctcgggcctg gcctaaaatg cacacagtca atggttatgt aaacaggtct 780 ctgccaggtc tgattggatg ccacaggaaa tcagtctatt ggcatgtgat tggaatgggc 840 accactcctg aagtgcactc aatattcctc gaaggtcaca catttcttgt gaggaaccat 900 cgccaggcgt ccttggaaat ctcgccaata actttcctta ctgctcaaac actcttgatg 960 gaccttggac agtttctact gttttgtcat atctcttccc accaacatga tggcatggaa 1020 gcttatgtca aagtagacag ctgtccagag gaaccccaac tacgaatgaa aaataatgaa 1080 gaagcggaag actatgatga tgatcttact gattctgaaa tggatgtggt caggtttgat 1140 gatgacaact ctccttcctt tatccaaatt cgctcagttg ccaagaagca tcctaaaact 1200 tgggtacatt acattgctgc tgaagaggag gactgggact atgctccctt agtcctcgcc 1260 cccgatgaca gaagttataa aagtcaatat ttgaacaatg gccctcagcg gattggtagg 1320 aagtacaaaa aagtccgatt tatggcatac acagatgaaa cctttaagac tcgtgaagct 1380 attcagcatg aatcaggaat cttgggacct ttactttatg gggaagttgg agacacactg 1440 ttgattatat ttaagaatca agcaagcaga ccatataaca tctaccctca cggaatcact 1500 gatgtccgtc ctttgtattc aaggagatta ccaaaaggtg taaaacattt gaaggatttt 1560 ccaattctgc caggagaaat attcaaatat aaatggacag tgactgtaga agatgggcca 1620 actaaatcag atcctcggtg cctgacccgc tattactcta gtttcgttaa tatggagaga 1680 gatctagctt caggactcat tggccctctc ctcatctgct acaaagaatc tgtagatcaa 1740 agaggaaacc agataatgtc agacaagagg aatgtcatcc tgttttctgt atttgatgag 1800 aaccgaagct ggtacctcac agagaatata caacgctttc tccccaatcc agctggagtg 1860 cagcttgagg atccagagtt ccaagcctcc aacatcatgc acagcatcaa tggctatgtt 1920 tttgatagtt tgcagttgtc agtttgtttg catgaggtgg catactggta cattctaagc 1980 attggagcac agactgactt cctttctgtc ttcttctctg gatatacctt caaacacaaa 2040 atggtctatg aagacacact caccctattc ccattctcag gagaaactgt cttcatgtcg 2100 atggaaaacc caggtctatg gattctgggg tgccacaact cagactttcg gaacagaggc 2160 atgaccgcct tactgaaggt ttctagttgt gacaagaaca ctggtgatta ttacgaggac 2220 agttatgaag atatttcagc atacttgctg agtaaaaaca atgccattga accaagaagc 2280 ttctcccaga attcaagaca ccctagcact aggcaaaagc aatttaatgc caccacaatt 2340 ccagaaaatg acatagagaa gactgaccct tggtttgcac acagaacacc tatgcctaaa 2400 atacaaaatg tctcctctag tgatttgttg atgctcttgc gacagagtcc tactccacat 2460 gggctatcct tatctgatct ccaagaagcc aaatatgaga ctttttctga tgatccatca 2520 cctggagcaa tagacagtaa taacagcctg tctgaaatga cacacttcag gccacagctc 2580 catcacagtg gggacatggt atttacccct gagtcaggcc tccaattaag attaaatgag 2640 aaactgggga caactgcagc aacagagttg aagaaacttg atttcaaagt ttctagtaca 2700 tcaaataatc tgatttcaac aattccatca gacaatttgg cagcaggtac tgataataca 2760 agttccttag gacccccaag tatgccagtt cattatgata gtcaattaga taccactcta 2820 tttggcaaaa agtcatctcc ccttactgag tctggtggac ctctgagctt gagtgaagaa 2880 aataatgatt caaagttgtt agaatcaggt ttaatgaata gccaagaaag ttcatgggga 2940 aaaaatgtat cgtcaacaga gagtggtagg ttatttaaag ggaaaagagc tcatggacct 3000 gctttgttga ctaaagataa tgccttattc aaagttagca tctctttgtt aaagacaaac 3060 aaaacttcca ataattcagc aactaataga aagactcaca ttgatggccc atcattatta 3120 attgagaata gtccatcagt ctggcaaaat atattagaaa gtgacactga gtttaaaaaa 3180 gtgacacctt tgattcatga cagaatgctt atggacaaaa atgctacagc tttgaggcta 3240 aatcatatgt caaataaaac tacttcatca aaaaacatgg aaatggtcca acagaaaaaa 3300 gagggcccca ttccaccaga tgcacaaaat ccagatatgt cgttctttaa gatgctattc 3360 ttgccagaat cagcaaggtg gatacaaagg actcatggaa agaactctct gaactctggg 3420 caaggcccca gtccaaagca attagtatcc ttaggaccag aaaaatctgt ggaaggtcag 3480 aatttcttgt ctgagaaaaa caaagtggta gtaggaaagg gtgaatttac aaaggacgta 3540 ggactcaaag agatggtttt tccaagcagc agaaacctat ttcttactaa cttggataat 3600 ttacatgaaa ataatacaca caatcaagaa aaaaaaattc aggaagaaat agaaaagaag 3660 gaaacattaa tccaagagaa tgtagttttg cctcagatac atacagtgac tggcactaag 3720 aatttcatga agaacctttt cttactgagc actaggcaaa atgtagaagg ttcatatgac 3780 ggggcatatg ctccagtact tcaagatttt aggtcattaa atgattcaac aaatagaaca 3840 aagaaacaca cagctcattt ctcaaaaaaa ggggaggaag aaaacttgga aggcttggga 3900 aatcaaacca agcaaattgt agagaaatat gcatgcacca caaggatatc tcctaataca 3960 agccagcaga attttgtcac gcaacgtagt aagagagctt tgaaacaatt cagactccca 4020 ctagaagaaa cagaacttga aaaaaggata attgtggatg acacctcaac ccagtggtcc 4080 aaaaacatga aacatttgac cccgagcacc ctcacacaga tagactacaa tgagaaggag 4140 aaaggggcca ttactcagtc tcccttatca gattgcctta cgaggagtca tagcatccct 4200 caagcaaata gatctccatt acccattgca aaggtatcat catttccatc tattagacct 4260 atatatctga ccagggtcct attccaagac aactcttctc atcttccagc agcatcttat 4320 agaaagaaag attctggggt ccaagaaagc agtcatttct tacaaggagc caaaaaaaat 4380 aacctttctt tagccattct aaccttggag atgactggtg atcaaagaga ggttggctcc 4440 ctggggacaa gtgccacaaa ttcagtcaca tacaagaaag ttgagaacac tgttctcccg 4500 aaaccagact tgcccaaaac atctggcaaa gttgaattgc ttccaaaagt tcacatttat 4560 cagaaggacc tattccctac ggaaactagc aatgggtctc ctggccatct ggatctcgtg 4620 gaagggagcc ttcttcaggg aacagaggga gcgattaagt ggaatgaagc aaacagacct 4680 ggaaaagttc cctttctgag agtagcaaca gaaagctctg caaagactcc ctccaagcta 4740 ttggatcctc ttgcttggga taaccactat ggtactcaga taccaaaaga agagtggaaa 4800 tcccaagaga agtcaccaga aaaaacagct tttaagaaaa aggataccat tttgtccctg 4860 aacgcttgtg aaagcaatca tgcaatagca gcaataaatg agggacaaaa taagcccgaa 4920 atagaagtca cctgggcaaa gcaaggtagg actgaaaggc tgtgctctca aaacccacca 4980 gtcttgaaac gccatcaacg ggaaataact cgtactactc ttcagtcaga tcaagaggaa 5040 attgactatg atgataccat atcagttgaa atgaagaagg aagattttga catttatgat 5100 gaggatgaaa atcagagccc ccgcagcttt caaaagaaaa cacgacacta ttttattgct 5160 gcagtggaga ggctctggga ttatgggatg agtagctccc cacatgttct aagaaacagg 5220 gctcagagtg gcagtgtccc tcagttcaag aaagttgttt tccaggaatt tactgatggc 5280 tcctttactc agcccttata ccgtggagaa ctaaatgaac atttgggact cctggggcca 5340 tatataagag cagaagttga agataatatc atggtaactt tcagaaatca ggcctctcgt 5400 ccctattcct tctattctag ccttatttct tatgaggaag atcagaggca aggagcagaa 5460 cctagaaaaa actttgtcaa gcctaatgaa accaaaactt acttttggaa agtgcaacat 5520 catatggcac ccactaaaga tgagtttgac tgcaaagcct gggcttattt ctctgatgtt 5580 gacctggaaa aagatgtgca ctcaggcctg attggacccc ttctggtctg ccacactaac 5640 acactgaacc ctgctcatgg gagacaagtg acagtacagg aatttgctct gtttttcacc 5700 atctttgatg agaccaaaag ctggtacttc actgaaaata tggaaagaaa ctgcagggct 5760 ccctgcaata tccagatgga agatcccact tttaaagaga attatcgctt ccatgcaatc 5820 aatggctaca taatggatac actacctggc ttagtaatgg ctcaggatca aaggattcga 5880 tggtatctgc tcagcatggg cagcaatgaa aacatccatt ctattcattt cagtggacat 5940 gtgttcactg tacgaaaaaa agaggagtat aaaatggcac tgtacaatct ctatccaggt 6000 gtttttgaga cagtggaaat gttaccatcc aaagctggaa tttggcgggt ggaatgcctt 6060 attggcgagc atctacatgc tgggatgagc acactttttc tggtgtacag caataagtgt 6120 cagactcccc tgggaatggc ttctggacac attagagatt ttcagattac agcttcagga 6180 caatatggac agtgggcccc aaagctggcc agacttcatt attccggatc aatcaatgcc 6240 tggagcacca aggagccctt ttcttggatc aaggtggatc tgttggcacc aatgattatt 6300 cacggcatca agacccaggg tgcccgtcag aagttctcca gcctctacat ctctcagttt 6360 atcatcatgt atagtcttga tgggaagaag tggcagactt atcgaggaaa ttccactgga 6420 accttaatgg tcttctttgg caatgtggat tcatctggga taaaacacaa tatttttaac 6480 cctccaatta ttgctcgata catccgtttg cacccaactc attatagcat tcgcagcact 6540 cttcgcatgg agttgatggg ctgtgattta aatagttgca gcatgccatt gggaatggag 6600 agtaaagcaa tatcagatgc acagattact gcttcatcct actttaccaa tatgtttgcc 6660 acctggtctc cttcaaaagc tcgacttcac ctccaaggga ggagtaatgc ctggagacct 6720 caggtgaata atccaaaaga gtggctgcaa gtggacttcc agaagacaat gaaagtcaca 6780 ggagtaacta ctcagggagt aaaatctctg cttaccagca tgtatgtgaa ggagttcctc 6840 atctccagca gtcaagatgg ccatcagtgg actctctttt ttcagaatgg caaagtaaag 6900 gtttttcagg gaaatcaaga ctccttcaca cctgtggtga actctctaga cccaccgtta 6960 ctgactcgct accttcgaat tcacccccag agttgggtgc accagattgc cctgaggatg 7020 gaggttctgg gctgcgaggc acaggacctc tac 7053 <210> 108 <400> 108 000 <210> 109 <211> 1718 <212> PRT <213> Secuencia Artificial <220> <223> Secuencia BIVV001 FVIII BDD (XTEN) (no Fc) <400> 109 Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 1 5 10 15 Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 20 25 30 Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 35 40 45 Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 50 55 60 Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 65 70 75 80 Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 85 90 95 Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 100 105 110 Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 115 120 125 Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 130 135 140 Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 145 150 155 160 His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 165 170 175 Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 180 185 190 His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 195 200 205 His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 210 215 220 Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 225 230 235 240 Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 245 250 255 Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 260 265 270 Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 275 280 285 Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 290 295 300 Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 305 310 315 320 Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 325 330 335 Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 340 345 350 Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 355 360 365 Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 370 375 380 Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 385 390 395 400 Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 405 410 415 Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 420 425 430 Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 435 440 445 Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 450 455 460 Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 465 470 475 480 Thr Asp Val Arg Pro Lys Arg Arg Leu Pro Lys Gly Val Lys His Leu 485 490 495 Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys Trp Thr 500 505 510 Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr 515 520 525 Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala Ser Gly 530 535 540 Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp Gln Arg 545 550 555 560 Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe Ser Val 565 570 575 Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln Arg Phe 580 585 590 Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe Gln Ala 595 600 605 Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu Gln 610 615 620 Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu Ser Ile 625 630 635 640 Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr Phe 645 650 655 Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe Ser 660 665 670 Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp Ile Leu 675 680 685 Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala Leu Leu 690 695 700 Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu Asp Ser 705 710 715 720 Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala Ile Glu 725 730 735 Pro Arg Ser Phe Ser Gln Asn Gly Thr Ser Glu Ser Ala Thr Pro Glu 740 745 750 Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 755 760 765 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 770 775 780 Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 785 790 795 800 Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 805 810 815 Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser 820 825 830 Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 835 840 845 Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 850 855 860 Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly 865 870 875 880 Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly 885 890 895 Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 900 905 910 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser 915 920 925 Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 930 935 940 Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 945 950 955 960 Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu 965 970 975 Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 980 985 990 Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 995 1000 1005 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 1010 1015 1020 Glu Pro Ser Glu Gly Ser Ala Pro Ala Ser Ser Glu Ile Thr Arg 1025 1030 1035 Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp Asp Thr 1040 1045 1050 Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp Glu 1055 1060 1065 Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His 1070 1075 1080 Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser 1085 1090 1095 Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val 1100 1105 1110 Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser 1115 1120 1125 Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly 1130 1135 1140 Leu Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met 1145 1150 1155 Val Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser 1160 1165 1170 Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro 1175 1180 1185 Arg Lys Asn Phe Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp 1190 1195 1200 Lys Val Gln His His Met Ala Pro Thr Lys Asp Glu Phe Asp Cys 1205 1210 1215 Lys Ala Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys Asp Val 1220 1225 1230 His Ser Gly Leu Ile Gly Pro Leu Leu Val Cys His Thr Asn Thr 1235 1240 1245 Leu Asn Pro Ala His Gly Arg Gln Val Thr Val Gln Glu Phe Ala 1250 1255 1260 Leu Phe Phe Thr Ile Phe Asp Glu Thr Lys Ser Trp Tyr Phe Thr 1265 1270 1275 Glu Asn Met Glu Arg Asn Cys Arg Ala Pro Cys Asn Ile Gln Met 1280 1285 1290 Glu Asp Pro Thr Phe Lys Glu Asn Tyr Arg Phe His Ala Ile Asn 1295 1300 1305 Gly Tyr Ile Met Asp Thr Leu Pro Gly Leu Val Met Ala Gln Asp 1310 1315 1320 Gln Arg Ile Arg Trp Tyr Leu Leu Ser Met Gly Ser Asn Glu Asn 1325 1330 1335 Ile His Ser Ile His Phe Ser Gly His Val Phe Thr Val Arg Lys 1340 1345 1350 Lys Glu Glu Tyr Lys Met Ala Leu Tyr Asn Leu Tyr Pro Gly Val 1355 1360 1365 Phe Glu Thr Val Glu Met Leu Pro Ser Lys Ala Gly Ile Trp Arg 1370 1375 1380 Val Glu Cys Leu Ile Gly Glu His Leu His Ala Gly Met Ser Thr 1385 1390 1395 Leu Phe Leu Val Tyr Ser Asn Lys Cys Gln Thr Pro Leu Gly Met 1400 1405 1410 Ala Ser Gly His Ile Arg Asp Phe Gln Ile Thr Ala Ser Gly Gln 1415 1420 1425 Tyr Gly Gln Trp Ala Pro Lys Leu Ala Arg Leu His Tyr Ser Gly 1430 1435 1440 Ser Ile Asn Ala Trp Ser Thr Lys Glu Pro Phe Ser Trp Ile Lys 1445 1450 1455 Val Asp Leu Leu Ala Pro Met Ile Ile His Gly Ile Lys Thr Gln 1460 1465 1470 Gly Ala Arg Gln Lys Phe Ser Ser Leu Tyr Ile Ser Gln Phe Ile 1475 1480 1485 Ile Met Tyr Ser Leu Asp Gly Lys Lys Trp Gln Thr Tyr Arg Gly 1490 1495 1500 Asn Ser Thr Gly Thr Leu Met Val Phe Phe Gly Asn Val Asp Ser 1505 1510 1515 Ser Gly Ile Lys His Asn Ile Phe Asn Pro Pro Ile Ile Ala Arg 1520 1525 1530 Tyr Ile Arg Leu His Pro Thr His Tyr Ser Ile Arg Ser Thr Leu 1535 1540 1545 Arg Met Glu Leu Met Gly Cys Asp Leu Asn Ser Cys Ser Met Pro 1550 1555 1560 Leu Gly Met Glu Ser Lys Ala Ile Ser Asp Ala Gln Ile Thr Ala 1565 1570 1575 Ser Ser Tyr Phe Thr Asn Met Phe Ala Thr Trp Ser Pro Ser Lys 1580 1585 1590 Ala Arg Leu His Leu Gln Gly Arg Ser Asn Ala Trp Arg Pro Gln 1595 1600 1605 Val Asn Asn Pro Lys Glu Trp Leu Gln Val Asp Phe Gln Lys Thr 1610 1615 1620 Met Lys Val Thr Gly Val Thr Thr Gln Gly Val Lys Ser Leu Leu 1625 1630 1635 Thr Ser Met Tyr Val Lys Glu Phe Leu Ile Ser Ser Ser Gln Asp 1640 1645 1650 Gly His Gln Trp Thr Leu Phe Phe Gln Asn Gly Lys Val Lys Val 1655 1660 1665 Phe Gln Gly Asn Gln Asp Ser Phe Thr Pro Val Val Asn Ser Leu 1670 1675 1680 Asp Pro Pro Leu Leu Thr Arg Tyr Leu Arg Ile His Pro Gln Ser 1685 1690 1695 Trp Val His Gln Ile Ala Leu Arg Met Glu Val Leu Gly Cys Glu 1700 1705 1710 Ala Gln Asp Leu Tyr 1715 <210> 110 <211> 6526 <212> ADN <213> Secuencia Artificial <220> <223> Construcción NB15.1v32 (AAV-FVIIIco6XTEN-DNAhs) <400> 110 ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt 60 ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact 120 aggggttcct gcggcaattc agtcgataac tataacggtc ctaaggtagc gatttaaata 180 cgcgctctct taaggtagcc ccgggacgcg tcaattgaga tctggatccg gtaccgaatt 240 cgcggccgcc tcgacgacta gcgtttaatt aaacgcgtgt ctgtctgcac atttcgtaga 300 gcgagtgttc cgatactcta atctccctag gcaaggttca tatttgtgta ggttacttat 360 tctccttttg ttgactaagt caataatcag aatcagcagg tttggagtca gcttggcagg 420 gatcagcagc ctgggttgga aggagggggt ataaaagccc cttcaccagg agaagccgtc 480 acacagatcc acaagctcct gaggtaagtg ccgtgtgtgg ttcccgcggg cctggcctct 540 ttacgggtta tggcccttgc gtgccttgaa ttactgacac tgacatccac tttttctttt 600 tctccacagc tagcgccacc atgcagattg agctgtccac ttgtttcttc ctgtgcctcc 660 tgcgcttctg tttctccgcc actcgccggt actaccttgg agccgtggag ctttcatggg 720 actacatgca gagcgacctg ggcgaactcc ccgtggatgc cagattcccc ccccgcgtgc 780 caaagtcctt cccctttaac acctccgtgg tgtacaagaa aaccctcttt gtcgagttca 840 ctgaccacct gttcaacatc gccaagccgc gcccaccttg gatgggcctc ctgggaccga 900 ccattcaagc tgaagtgtac gacaccgtgg tgatcaccct gaagaacatg gcgtcccacc 960 ccgtgtccct gcatgcggtc ggagtgtcct actggaaggc ctccgaagga gctgagtacg 1020 acgaccagac tagccagcgg gaaaaggagg acgataaagt gttcccgggc ggctcgcata 1080 cttacgtgtg gcaagtcctg aaggaaaacg gacctatggc atccgatcct ctgtgcctga 1140 cttactccta cctttcccat gtggacctcg tgaaggacct gaacagcggg ctgattggtg 1200 cacttctcgt gtgccgcgaa ggttcgctcg ctaaggaaaa gacccagacc ctccataagt 1260 tcatcctttt gttcgctgtg ttcgatgaag gaaagtcatg gcattccgaa actaagaact 1320 cgctgatgca ggaccgggat gccgcctcag cccgcgcctg gcctaaaatg catacagtca 1380 acggatacgt gaatcggtca ctgcccgggc tcatcggttg tcacagaaag tccgtgtact 1440 ggcacgtcat cggcatgggc actacgcctg aagtgcactc catcttcctg gaagggcaca 1500 ccttcctcgt gcgcaaccac cgccaggcct ctctggaaat ctccccgatt acctttctga 1560 ccgcccagac tctgctcatg gacctggggc agttccttct cttctgccac atctccagcc 1620 atcagcacga cggaatggag gcctacgtga aggtggactc atgcccggaa gaacctcagt 1680 tgcggatgaa gaacaacgag gaggccgagg actatgacga cgatttgact gactccgaga 1740 tggacgtcgt gcggttcgat gacgacaaca gccccagctt catccagatt cgcagcgtgg 1800 ccaagaagca ccccaaaacc tgggtgcact acatcgcggc cgaggaagaa gattgggact 1860 acgccccgtt ggtgctggca cccgatgacc ggtcgtacaa gtcccagtat ctgaacaatg 1920 gtccgcagcg gattggcaga aagtacaaga aagtgcggtt catggcgtac actgacgaaa 1980 cgtttaagac ccgggaggcc attcaacatg agagcggcat tctgggacca ctgctgtacg 2040 gagaggtcgg cgataccctg ctcatcatct tcaaaaacca ggcctcccgg ccttacaaca 2100 tctaccctca cggaatcacc gacgtgcggc cactctactc gcggcgcctg ccgaagggcg 2160 tcaagcacct gaaagacttc cctatcctgc cgggcgaaat cttcaagtat aagtggaccg 2220 tcaccgtgga ggacgggccc accaagagcg atcctaggtg tctgactcgg tactactcca 2280 gcttcgtgaa catggaacgg gacctggcat cgggactcat tggaccgctg ctgatctgct 2340 acaaagagtc ggtggatcaa cgcggcaacc agatcatgtc cgacaagcgc aacgtgatcc 2400 tgttctccgt gtttgatgaa aacagatcct ggtacctcac tgaaaacatc cagaggttcc 2460 tcccaaaccc cgcaggagtg caactggagg accctgagtt tcaggcctcg aatatcatgc 2520 actcgattaa cggttacgtg ttcgactcgc tgcaactgag cgtgtgcctc catgaagtcg 2580 cttactggta cattctgtcc atcggcgccc agactgactt cctgagcgtg ttcttttccg 2640 gttacacctt taagcacaag atggtgtacg aagataccct gaccctgttc cctttctccg 2700 gcgaaacggt gttcatgtcg atggagaacc cgggtctgtg gattctggga tgccacaaca 2760 gcgactttcg gaaccgcgga atgactgccc tgctgaaggt gtcctcatgc gacaagaaca 2820 ccggagacta ctacgaggac tcctacgagg atatctcagc ctacctcctg tccaagaaca 2880 acgcgatcga gccgcgcagc ttcagccaga acggcgcgcc aacatcagag agcgccaccc 2940 ctgaaagtgg tcccgggagc gagccagcca catctgggtc ggaaacgcca ggcacaagtg 3000 agtctgcaac tcccgagtcc ggacctggct ccgagcctgc cactagcggc tccgagactc 3060 cgggaacttc cgagagcgct acaccagaaa gcggacccgg aaccagtacc gaacctagcg 3120 agggctctgc tccgggcagc ccagccggct ctcctacatc cacggaggag ggcacttccg 3180 aatccgccac cccggagtca gggccaggat ctgaacccgc tacctcaggc agtgagacgc 3240 caggaacgag cgagtccgct acaccggaga gtgggccagg gagccctgct ggatctccta 3300 cgtccactga ggaagggtca ccagcgggct cgcccaccag cactgaagaa ggtgcctcga 3360 gcccgcctgt gctgaagagg caccagcgag aaattacccg gaccaccctc caatcggatc 3420 aggaggaaat cgactacgac gacaccatct cggtggaaat gaagaaggaa gatttcgata 3480 tctacgacga ggacgaaaat cagtcccctc gctcattcca aaagaaaact agacactact 3540 ttatcgccgc ggtggaaaga ctgtgggact atggaatgtc atccagccct cacgtccttc 3600 ggaaccgggc ccagagcgga tcggtgcctc agttcaagaa agtggtgttc caggagttca 3660 ccgacggcag cttcacccag ccgctgtacc ggggagaact gaacgaacac ctgggcctgc 3720 tcggtcccta catccgcgcg gaagtggagg ataacatcat ggtgaccttc cgtaaccaag 3780 catccagacc ttactccttc tattcctccc tgatctcata cgaggaggac cagcgccaag 3840 gcgccgagcc ccgcaagaac ttcgtcaagc ccaacgagac taagacctac ttctggaagg 3900 tccaacacca tatggccccg accaaggatg agtttgactg caaggcctgg gcctacttct 3960 ccgacgtgga ccttgagaag gatgtccatt ccggcctgat cgggccgctg ctcgtgtgtc 4020 acaccaacac cctgaaccca gcgcatggac gccaggtcac cgtccaggag tttgctctgt 4080 tcttcaccat ttttgacgaa actaagtcct ggtacttcac cgagaatatg gagcgaaact 4140 gtagagcgcc ctgcaatatc cagatggaag atccgacttt caaggagaac tatagattcc 4200 acgccatcaa cgggtacatc atggatactc tgccggggct ggtcatggcc caggatcaga 4260 ggattcggtg gtacttgctg tcaatgggat cgaacgaaaa cattcactcc attcacttct 4320 ccggtcacgt gttcactgtg cgcaagaagg aggagtacaa gatggcgctg tacaatctgt 4380 accccggggt gttcgaaact gtggagatgc tgccgtccaa ggccggcatc tggagagtgg 4440 agtgcctgat cggagagcac ctccacgcgg ggatgtccac cctcttcctg gtgtactcga 4500 ataagtgcca gaccccgctg ggcatggcct cgggccacat cagagacttc cagatcacag 4560 caagcggaca atacggccaa tgggcgccga agctggcccg cttgcactac tccggatcga 4620 tcaacgcatg gtccaccaag gaaccgttct cgtggattaa ggtggacctc ctggccccta 4680 tgattatcca cggaattaag acccagggcg ccaggcagaa gttctcctcc ctgtacatct 4740 cgcaattcat catcatgtac agcctggacg ggaagaagtg gcagacttac aggggaaact 4800 ccaccggcac cctgatggtc tttttcggca acgtggattc ctccggcatt aagcacaaca 4860 tcttcaaccc accgatcata gccagatata ttaggctcca ccccactcac tactcaatcc 4920 gctcaactct tcggatggaa ctcatggggt gcgacctgaa ctcctgctcc atgccgttgg 4980 ggatggaatc aaaggctatt agcgacgccc agatcaccgc gagctcctac ttcactaaca 5040 tgttcgccac ctggagcccc tccaaggcca ggctgcactt gcagggacgg tcaaatgcct 5100 ggcggccgca agtgaacaat ccgaaggaat ggcttcaagt ggatttccaa aagaccatga 5160 aagtgaccgg agtcaccacc cagggagtga agtcccttct gacctcgatg tatgtgaagg 5220 agttcctgat tagcagcagc caggacgggc accagtggac cctgttcttc caaaacggaa 5280 aggtcaaggt gttccagggg aaccaggact cgttcacacc cgtggtgaac tccctggacc 5340 ccccactgct gacgcggtac ttgaggattc atcctcagtc ctgggtccat cagattgcat 5400 tgcgaatgga agtcctgggc tgcgaggccc aggacctgta ctgaatcagc ctgagctcgc 5460 tgatcataat caacctctgg attacaaaat ttgtgaaaga ttgactggta ttcttaacta 5520 tgttgctcct tttacgctat gtggatacgc tgctttaatg cctttgtatc atgctattgc 5580 ttcccgtatg gctttcattt tctcctcctt gtataaatcc tggttgctgt ctctttatga 5640 ggagttgtgg cccgttgtca ggcaacgtgg cgtggtgtgc actgtgtttg ctgacgcaac 5700 ccccactggt tggggcattg ccaccacctg tcagctcctt tccgggactt tcgctttccc 5760 cctccctatt gccacggcgg aactcatcgc cgcctgcctt gcccgctgct ggacaggggc 5820 tcggctgttg ggcactgaca attccgtggt gttgtcgggg aaatcatcgt cctttccttg 5880 gctgctcgcc tgtgttgcca cctggattct gcgcgggacg tccttctgct acgtcccttc 5940 ggccctcaat ccagcggacc ttccttcccg cggcctgctg ccggctctgc ggcctcttcc 6000 gcgtcttcgc cttcgccctc agacgagtcg gatctccctt tgggccgcct ccccgctgat 6060 cagcctcgac tgtgccttct agttgccagc catctgttgt ttgcccctcc cccgtgcctt 6120 ccttgaccct ggaaggtgcc actcccactg tcctttccta ataaaatgag gaaattgcat 6180 cgcattgtct gagtaggtgt cattctattc tggggggtgg ggtggggcag gacagcaagg 6240 gggaggattg ggaagacaat agcaggcatg ctggggatgc ggtgggctct atggcttctg 6300 aggcggaaag aacgggctcg agaagcttct agatatcctc tcttaaggta gcatcgagat 6360 ttaaattagg gataacaggg taatggcgcg ggccgcagga acccctagtg atggagttgg 6420 ccactccctc tctgcgcgct cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac 6480 gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc gcgcag 6526 <210> 111 <211> 130 <212> ADN <213> Secuencia Artificial <220> <223> ITR 5' (repetición terminal invertida de AAV2 extremo 5') <400> 111 ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt 60 ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact 120 aggggttcct 130 <210> 112 <211> 142 <212> ADN <213> Secuencia Artificial <220> <223> Secuencia del Esqueleto Plasmídico (PBS)-1 <400> 112 gcggcaattc agtcgataac tataacggtc ctaaggtagc gatttaaata cgcgctctct 60 taaggtagcc ccgggacgcg tcaattgaga tctggatccg gtaccgaatt cgcggccgcc 120 tcgacgacta gcgtttaatt aa 142 <210> 113 <211> 229 <212> ADN <213> Secuencia Artificial <220> <223> TTPp (promotor específico de hígado) <400> 113 acgcgtgtct gtctgcacat ttcgtagagc gagtgttccg atactctaat ctccctaggc 60 aaggttcata tttgtgtagg ttacttattc tccttttgtt gactaagtca ataatcagaa 120 tcagcaggtt tggagtcagc ttggcaggga tcagcagcct gggttggaag gagggggtat 180 aaaagcccct tcaccaggag aagccgtcac acagatccac aagctcctg 229 <210> 114 <211> 2 <212> ADN <213> Secuencia Artificial <220> <223> Secuencia del Esqueleto Plasmídico (PBS)-2 <400> 114 ag 2 <210> 115 <211> 106 <212> ADN <213> Secuencia Artificial <220> <223> Intrón Sintético <400> 115 gtaagtgccg tgtgtggttc ccgcgggcct ggcctcttta cgggttatgg cccttgcgtg 60 ccttgaatta ctgacactga catccacttt ttctttttct ccacag 106 <210> 116 <211> 11 <212> ADN <213> Secuencia Artificial <220> <223> Secuencia del Esqueleto Plasmídico (PBS)-3 <400> 116 ctagcgccac c 11 <210> 117 <211> 4824 <212> ADN <213> Secuencia Artificial <220> <223> FVIIIco6XTEN (marco de lectura abierto para la versión 6 de FVIII con codones optimizados que contiene XTEN144) <400> 117 atgcagattg agctgtccac ttgtttcttc ctgtgcctcc tgcgcttctg tttctccgcc 60 actcgccggt actaccttgg agccgtggag ctttcatggg actacatgca gagcgacctg 120 ggcgaactcc ccgtggatgc cagattcccc ccccgcgtgc caaagtcctt cccctttaac 180 acctccgtgg tgtacaagaa aaccctcttt gtcgagttca ctgaccacct gttcaacatc 240 gccaagccgc gcccaccttg gatgggcctc ctgggaccga ccattcaagc tgaagtgtac 300 gacaccgtgg tgatcaccct gaagaacatg gcgtcccacc ccgtgtccct gcatgcggtc 360 ggagtgtcct actggaaggc ctccgaagga gctgagtacg acgaccagac tagccagcgg 420 gaaaaggagg acgataaagt gttcccgggc ggctcgcata cttacgtgtg gcaagtcctg 480 aaggaaaacg gacctatggc atccgatcct ctgtgcctga cttactccta cctttcccat 540 gtggacctcg tgaaggacct gaacagcggg ctgattggtg cacttctcgt gtgccgcgaa 600 ggttcgctcg ctaaggaaaa gacccagacc ctccataagt tcatcctttt gttcgctgtg 660 ttcgatgaag gaaagtcatg gcattccgaa actaagaact cgctgatgca ggaccgggat 720 gccgcctcag cccgcgcctg gcctaaaatg catacagtca acggatacgt gaatcggtca 780 ctgcccgggc tcatcggttg tcacagaaag tccgtgtact ggcacgtcat cggcatgggc 840 actacgcctg aagtgcactc catcttcctg gaagggcaca ccttcctcgt gcgcaaccac 900 cgccaggcct ctctggaaat ctccccgatt acctttctga ccgcccagac tctgctcatg 960 gacctggggc agttccttct cttctgccac atctccagcc atcagcacga cggaatggag 1020 gcctacgtga aggtggactc atgcccggaa gaacctcagt tgcggatgaa gaacaacgag 1080 gaggccgagg actatgacga cgatttgact gactccgaga tggacgtcgt gcggttcgat 1140 gacgacaaca gccccagctt catccagatt cgcagcgtgg ccaagaagca ccccaaaacc 1200 tgggtgcact acatcgcggc cgaggaagaa gattgggact acgccccgtt ggtgctggca 1260 cccgatgacc ggtcgtacaa gtcccagtat ctgaacaatg gtccgcagcg gattggcaga 1320 aagtacaaga aagtgcggtt catggcgtac actgacgaaa cgtttaagac ccgggaggcc 1380 attcaacatg agagcggcat tctgggacca ctgctgtacg gagaggtcgg cgataccctg 1440 ctcatcatct tcaaaaacca ggcctcccgg ccttacaaca tctaccctca cggaatcacc 1500 gacgtgcggc cactctactc gcggcgcctg ccgaagggcg tcaagcacct gaaagacttc 1560 cctatcctgc cgggcgaaat cttcaagtat aagtggaccg tcaccgtgga ggacgggccc 1620 accaagagcg atcctaggtg tctgactcgg tactactcca gcttcgtgaa catggaacgg 1680 gacctggcat cgggactcat tggaccgctg ctgatctgct acaaagagtc ggtggatcaa 1740 cgcggcaacc agatcatgtc cgacaagcgc aacgtgatcc tgttctccgt gtttgatgaa 1800 aacagatcct ggtacctcac tgaaaacatc cagaggttcc tcccaaaccc cgcaggagtg 1860 caactggagg accctgagtt tcaggcctcg aatatcatgc actcgattaa cggttacgtg 1920 ttcgactcgc tgcaactgag cgtgtgcctc catgaagtcg cttactggta cattctgtcc 1980 atcggcgccc agactgactt cctgagcgtg ttcttttccg gttacacctt taagcacaag 2040 atggtgtacg aagataccct gaccctgttc cctttctccg gcgaaacggt gttcatgtcg 2100 atggagaacc cgggtctgtg gattctggga tgccacaaca gcgactttcg gaaccgcgga 2160 atgactgccc tgctgaaggt gtcctcatgc gacaagaaca ccggagacta ctacgaggac 2220 tcctacgagg atatctcagc ctacctcctg tccaagaaca acgcgatcga gccgcgcagc 2280 ttcagccaga acggcgcgcc aacatcagag agcgccaccc ctgaaagtgg tcccgggagc 2340 gagccagcca catctgggtc ggaaacgcca ggcacaagtg agtctgcaac tcccgagtcc 2400 ggacctggct ccgagcctgc cactagcggc tccgagactc cgggaacttc cgagagcgct 2460 acaccagaaa gcggacccgg aaccagtacc gaacctagcg agggctctgc tccgggcagc 2520 ccagccggct ctcctacatc cacggaggag ggcacttccg aatccgccac cccggagtca 2580 gggccaggat ctgaacccgc tacctcaggc agtgagacgc caggaacgag cgagtccgct 2640 acaccggaga gtgggccagg gagccctgct ggatctccta cgtccactga ggaagggtca 2700 ccagcgggct cgcccaccag cactgaagaa ggtgcctcga gcccgcctgt gctgaagagg 2760 caccagcgag aaattacccg gaccaccctc caatcggatc aggaggaaat cgactacgac 2820 gacaccatct cggtggaaat gaagaaggaa gatttcgata tctacgacga ggacgaaaat 2880 cagtcccctc gctcattcca aaagaaaact agacactact ttatcgccgc ggtggaaaga 2940 ctgtgggact atggaatgtc atccagccct cacgtccttc ggaaccgggc ccagagcgga 3000 tcggtgcctc agttcaagaa agtggtgttc caggagttca ccgacggcag cttcacccag 3060 ccgctgtacc ggggagaact gaacgaacac ctgggcctgc tcggtcccta catccgcgcg 3120 gaagtggagg ataacatcat ggtgaccttc cgtaaccaag catccagacc ttactccttc 3180 tattcctccc tgatctcata cgaggaggac cagcgccaag gcgccgagcc ccgcaagaac 3240 ttcgtcaagc ccaacgagac taagacctac ttctggaagg tccaacacca tatggccccg 3300 accaaggatg agtttgactg caaggcctgg gcctacttct ccgacgtgga ccttgagaag 3360 gatgtccatt ccggcctgat cgggccgctg ctcgtgtgtc acaccaacac cctgaaccca 3420 gcgcatggac gccaggtcac cgtccaggag tttgctctgt tcttcaccat ttttgacgaa 3480 actaagtcct ggtacttcac cgagaatatg gagcgaaact gtagagcgcc ctgcaatatc 3540 cagatggaag atccgacttt caaggagaac tatagattcc acgccatcaa cgggtacatc 3600 atggatactc tgccggggct ggtcatggcc caggatcaga ggattcggtg gtacttgctg 3660 tcaatgggat cgaacgaaaa cattcactcc attcacttct ccggtcacgt gttcactgtg 3720 cgcaagaagg aggagtacaa gatggcgctg tacaatctgt accccggggt gttcgaaact 3780 gtggagatgc tgccgtccaa ggccggcatc tggagagtgg agtgcctgat cggagagcac 3840 ctccacgcgg ggatgtccac cctcttcctg gtgtactcga ataagtgcca gaccccgctg 3900 ggcatggcct cgggccacat cagagacttc cagatcacag caagcggaca atacggccaa 3960 tgggcgccga agctggcccg cttgcactac tccggatcga tcaacgcatg gtccaccaag 4020 gaaccgttct cgtggattaa ggtggacctc ctggccccta tgattatcca cggaattaag 4080 acccagggcg ccaggcagaa gttctcctcc ctgtacatct cgcaattcat catcatgtac 4140 agcctggacg ggaagaagtg gcagacttac aggggaaact ccaccggcac cctgatggtc 4200 tttttcggca acgtggattc ctccggcatt aagcacaaca tcttcaaccc accgatcata 4260 gccagatata ttaggctcca ccccactcac tactcaatcc gctcaactct tcggatggaa 4320 ctcatggggt gcgacctgaa ctcctgctcc atgccgttgg ggatggaatc aaaggctatt 4380 agcgacgccc agatcaccgc gagctcctac ttcactaaca tgttcgccac ctggagcccc 4440 tccaaggcca ggctgcactt gcagggacgg tcaaatgcct ggcggccgca agtgaacaat 4500 ccgaaggaat ggcttcaagt ggatttccaa aagaccatga aagtgaccgg agtcaccacc 4560 cagggagtga agtcccttct gacctcgatg tatgtgaagg agttcctgat tagcagcagc 4620 caggacgggc accagtggac cctgttcttc caaaacggaa aggtcaaggt gttccagggg 4680 aaccaggact cgttcacacc cgtggtgaac tccctggacc ccccactgct gacgcggtac 4740 ttgaggattc atcctcagtc ctgggtccat cagattgcat tgcgaatgga agtcctgggc 4800 tgcgaggccc aggacctgta ctga 4824 <210> 118 <211> 450 <212> ADN <213> Secuencia Artificial <220> <223> XTEN144 <400> 118 ggcgcgccaa catcagagag cgccacccct gaaagtggtc ccgggagcga gccagccaca 60 tctgggtcgg aaacgccagg cacaagtgag tctgcaactc ccgagtccgg acctggctcc 120 gagcctgcca ctagcggctc cgagactccg ggaacttccg agagcgctac accagaaagc 180 ggacccggaa ccagtaccga acctagcgag ggctctgctc cgggcagccc agccggctct 240 cctacatcca cggaggaggg cacttccgaa tccgccaccc cggagtcagg gccaggatct 300 gaacccgcta cctcaggcag tgagacgcca ggaacgagcg agtccgctac accggagagt 360 gggccaggga gccctgctgg atctcctacg tccactgagg aagggtcacc agcgggctcg 420 cccaccagca ctgaagaagg tgcctcgagc 450 <210> 119 <211> 19 <212> ADN <213> Secuencia Artificial <220> <223> Secuencia del Esqueleto Plasmídico (PBS)-4 <400> 119 atcagcctga gctcgctga 19 <210> 120 <211> 595 <212> ADN <213> Secuencia Artificial <220> <223> WPRE (elemento regulador post-traduccional del virus de la hepatitis de marmota mutado) <400> 120 tcataatcaa cctctggatt acaaaatttg tgaaagattg actggtattc ttaactatgt 60 tgctcctttt acgctatgtg gatacgctgc tttaatgcct ttgtatcatg ctattgcttc 120 ccgtatggct ttcattttct cctccttgta taaatcctgg ttgctgtctc tttatgagga 180 gttgtggccc gttgtcaggc aacgtggcgt ggtgtgcact gtgtttgctg acgcaacccc 240 cactggttgg ggcattgcca ccacctgtca gctcctttcc gggactttcg ctttccccct 300 ccctattgcc acggcggaac tcatcgccgc ctgccttgcc cgctgctgga caggggctcg 360 gctgttgggc actgacaatt ccgtggtgtt gtcggggaaa tcatcgtcct ttccttggct 420 gctcgcctgt gttgccacct ggattctgcg cgggacgtcc ttctgctacg tcccttcggc 480 cctcaatcca gcggaccttc cttcccgcgg cctgctgccg gctctgcggc ctcttccgcg 540 tcttcgcctt cgccctcaga cgagtcggat ctccctttgg gccgcctccc cgctg 595 <210> 121 <211> 8 <212> ADN <213> Secuencia Artificial <220> <223> Secuencia del Esqueleto Plasmídico (PBS)-5 <400> 121 atcagcct 8 <210> 122 <211> 211 <212> ADN <213> Secuencia Artificial <220> <223> bGHpA (señal de poliadenilación de la hormona de crecimiento bovina) <400> 122 cgactgtgcc ttctagttgc cagccatctg ttgtttgccc ctcccccgtg ccttccttga 60 ccctggaagg tgccactccc actgtccttt cctaataaaa tgaggaaatt gcatcgcatt 120 gtctgagtag gtgtcattct attctggggg gtggggtggg gcaggacagc aagggggagg 180 attgggaaga caatagcagg catgctgggg a 211 <210> 123 <211> 119 <212> ADN <213> Secuencia Artificial <220> <223> Secuencia del Esqueleto Plasmídico (PBS)-6 <400> 123 tgcggtgggc tctatggctt ctgaggcgga aagaacgggc tcgagaagct tctagatatc 60 ctctcttaag gtagcatcga gatttaaatt agggataaca gggtaatggc gcgggccgc 119 <210> 124 <211> 130 <212> ADN <213> Secuencia Artificial <220> <223> ITR 3' (repetición terminal invertida de AAV2 extremo 3') <400> 124 aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg 60 ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc 120 gagcgcgcag 130 <210> 125 <211> 415 <212> PRT <213> Secuencia Artificial <220> <223> Polipéptido FIX Maduro <400> 125 Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg 1 5 10 15 Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe 20 25 30 Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly 35 40 45 Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp 50 55 60 Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys 65 70 75 80 Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu 85 90 95 Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr 100 105 110 Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val 115 120 125 Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr 130 135 140 Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu 145 150 155 160 Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn 165 170 175 Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe 180 185 190 Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly 195 200 205 Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu 210 215 220 Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu 225 230 235 240 Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His 245 250 255 His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu 260 265 270 Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile 275 280 285 Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser 290 295 300 Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala 305 310 315 320 Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys 325 330 335 Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly 340 345 350 Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro 355 360 365 His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser 370 375 380 Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys 385 390 395 400 Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 405 410 415 <210> 126 <211> 415 <212> PRT <213> Secuencia Artificial <220> <223> Polipéptido FIX Padua(R338L) Maduro <400> 126 Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg 1 5 10 15 Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe 20 25 30 Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly 35 40 45 Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp 50 55 60 Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys 65 70 75 80 Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu 85 90 95 Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr 100 105 110 Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val 115 120 125 Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr 130 135 140 Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu 145 150 155 160 Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn 165 170 175 Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe 180 185 190 Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly 195 200 205 Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu 210 215 220 Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu 225 230 235 240 Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His 245 250 255 His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu 260 265 270 Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile 275 280 285 Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser 290 295 300 Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala 305 310 315 320 Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys 325 330 335 Leu Leu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly 340 345 350 Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro 355 360 365 His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser 370 375 380 Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys 385 390 395 400 Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 405 410 415 <210> 127 <211> 46 <212> PRT <213> Secuencia Artificial <220> <223> Polipéptido Señal y Propéptido de FIX <400> 127 Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 1 5 10 15 Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 20 25 30 Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg 35 40 45 <210> 128 <211> 8442 <212> ADN <213> Secuencia Artificial <220> <223> VWF humano <400> 128 atgattcctg ccagatttgc cggggtgctg cttgctctgg ccctcatttt gccagggacc 60 ctttgtgcag aaggaactcg cggcaggtca tccacggccc gatgcagcct tttcggaagt 120 gacttcgtca acacctttga tgggagcatg tacagctttg cgggatactg cagttacctc 180 ctggcagggg gctgccagaa acgctccttc tcgattattg gggacttcca gaatggcaag 240 agagtgagcc tctccgtgta tcttggggaa ttttttgaca tccatttgtt tgtcaatggt 300 accgtgacac agggggacca aagagtctcc atgccctatg cctccaaagg gctgtatcta 360 gaaactgagg ctgggtacta caagctgtcc ggtgaggcct atggctttgt ggccaggatc 420 gatggcagcg gcaactttca agtcctgctg tcagacagat acttcaacaa gacctgcggg 480 ctgtgtggca actttaacat ctttgctgaa gatgacttta tgacccaaga agggaccttg 540 acctcggacc cttatgactt tgccaactca tgggctctga gcagtggaga acagtggtgt 600 gaacgggcat ctcctcccag cagctcatgc aacatctcct ctggggaaat gcagaagggc 660 ctgtgggagc agtgccagct tctgaagagc acctcggtgt ttgcccgctg ccaccctctg 720 gtggaccccg agccttttgt ggccctgtgt gagaagactt tgtgtgagtg tgctgggggg 780 ctggagtgcg cctgccctgc cctcctggag tacgcccgga cctgtgccca ggagggaatg 840 gtgctgtacg gctggaccga ccacagcgcg tgcagcccag tgtgccctgc tggtatggag 900 tataggcagt gtgtgtcccc ttgcgccagg acctgccaga gcctgcacat caatgaaatg 960 tgtcaggagc gatgcgtgga tggctgcagc tgccctgagg gacagctcct ggatgaaggc 1020 ctctgcgtgg agagcaccga gtgtccctgc gtgcattccg gaaagcgcta ccctcccggc 1080 acctccctct ctcgagactg caacacctgc atttgccgaa acagccagtg gatctgcagc 1140 aatgaagaat gtccagggga gtgccttgtc actggtcaat cccacttcaa gagctttgac 1200 aacagatact tcaccttcag tgggatctgc cagtacctgc tggcccggga ttgccaggac 1260 cactccttct ccattgtcat tgagactgtc cagtgtgctg atgaccgcga cgctgtgtgc 1320 acccgctccg tcaccgtccg gctgcctggc ctgcacaaca gccttgtgaa actgaagcat 1380 ggggcaggag ttgccatgga tggccaggac atccagctcc ccctcctgaa aggtgacctc 1440 cgcatccagc atacagtgac ggcctccgtg cgcctcagct acggggagga cctgcagatg 1500 gactgggatg gccgcgggag gctgctggtg aagctgtccc ccgtctatgc cgggaagacc 1560 tgcggcctgt gtgggaatta caatggcaac cagggcgacg acttccttac cccctctggg 1620 ctggcrgagc cccgggtgga ggacttcggg aacgcctgga agctgcacgg ggactgccag 1680 gacctgcaga agcagcacag cgatccctgc gccctcaacc cgcgcatgac caggttctcc 1740 gaggaggcgt gcgcggtcct gacgtccccc acattcgagg cctgccatcg tgccgtcagc 1800 ccgctgccct acctgcggaa ctgccgctac gacgtgtgct cctgctcgga cggccgcgag 1860 tgcctgtgcg gcgccctggc cagctatgcc gcggcctgcg cggggagagg cgtgcgcgtc 1920 gcgtggcgcg agccaggccg ctgtgagctg aactgcccga aaggccaggt gtacctgcag 1980 tgcgggaccc cctgcaacct gacctgccgc tctctctctt acccggatga ggaatgcaat 2040 gaggcctgcc tggagggctg cttctgcccc ccagggctct acatggatga gaggggggac 2100 tgcgtgccca aggcccagtg cccctgttac tatgacggtg agatcttcca gccagaagac 2160 atcttctcag accatcacac catgtgctac tgtgaggatg gcttcatgca ctgtaccatg 2220 agtggagtcc ccggaagctt gctgcctgac gctgtcctca gcagtcccct gtctcatcgc 2280 agcaaaagga gcctatcctg tcggcccccc atggtcaagc tggtgtgtcc cgctgacaac 2340 ctgcgggctg aagggctcga gtgtaccaaa acgtgccaga actatgacct ggagtgcatg 2400 agcatgggct gtgtctctgg ctgcctctgc cccccgggca tggtccggca tgagaacaga 2460 tgtgtggccc tggaaaggtg tccctgcttc catcagggca aggagtatgc ccctggagaa 2520 acagtgaaga ttggctgcaa cacttgtgtc tgtcgggacc ggaagtggaa ctgcacagac 2580 catgtgtgtg atgccacgtg ctccacgatc ggcatggccc actacctcac cttcgacggg 2640 ctcaaatacc tgttccccgg ggagtgccag tacgttctgg tgcaggatta ctgcggcagt 2700 aaccctggga cctttcggat cctagtgggg aataagggat gcagccaccc ctcagtgaaa 2760 tgcaagaaac gggtcaccat cctggtggag ggaggagaga ttgagctgtt tgacggggag 2820 gtgaatgtga agaggcccat gaaggatgag actcactttg aggtggtgga gtctggccgg 2880 tacatcattc tgctgctggg caaagccctc tccgtggtct gggaccgcca cctgagcatc 2940 tccgtggtcc tgaagcagac ataccaggag aaagtgtgtg gcctgtgtgg gaattttgat 3000 ggcatccaga acaatgacct caccagcagc aacctccaag tggaggaaga ccctgtggac 3060 tttgggaact cctggaaagt gagctcgcag tgtgctgaca ccagaaaagt gcctctggac 3120 tcatcccctg ccacctgcca taacaacatc atgaagcaga cgatggtgga ttcctcctgt 3180 agaatcctta ccagtgacgt cttccaggac tgcaacaagc tggtggaccc cgagccatat 3240 ctggatgtct gcatttacga cacctgctcc tgtgagtcca ttggggactg cgcctgcttc 3300 tgcgacacca ttgctgccta tgcccacgtg tgtgcccagc atggcaaggt ggtgacctgg 3360 aggacggcca cattgtgccc ccagagctgc gaggagagga atctccggga gaacgggtat 3420 gagtgtgagt ggcgctataa cagctgtgca cctgcctgtc aagtcacgtg tcagcaccct 3480 gagccactgg cctgccctgt gcagtgtgtg gagggctgcc atgcccactg ccctccaggg 3540 aaaatcctgg atgagctttt gcagacctgc gttgaccctg aagactgtcc agtgtgtgag 3600 gtggctggcc ggcgttttgc ctcaggaaag aaagtcacct tgaatcccag tgaccctgag 3660 cactgccaga tttgccactg tgatgttgtc aacctcacct gtgaagcctg ccaggagccg 3720 ggaggcctgg tggtgcctcc cacagatgcc ccggtgagcc ccaccactct gtatgtggag 3780 gacatctcgg aaccgccgtt gcacgatttc tactgcagca ggctactgga cctggtcttc 3840 ctgctggatg gctcctccag gctgtccgag gctgagtttg aagtgctgaa ggcctttgtg 3900 gtggacatga tggagcggct gcgcatctcc cagaagtggg tccgcgtggc cgtggtggag 3960 taccacgacg gctcccacgc ctacatcggg ctcaaggacc ggaagcgacc gtcagagctg 4020 cggcgcattg ccagccaggt gaagtatgcg ggcagccagg tggcctccac cagcgaggtc 4080 ttgaaataca cactgttcca aatcttcagc aagatcgacc gccctgaagc ctcccgcatc 4140 gccctgctcc tgatggccag ccaggagccc caacggatgt cccggaactt tgtccgctac 4200 gtccagggcc tgaagaagaa gaaggtcatt gtgatcccgg tgggcattgg gccccatgcc 4260 aacctcaagc agatccgcct catcgagaag caggcccctg agaacaaggc cttcgtgctg 4320 agcagtgtgg atgagctgga gcagcaaagg gacgagatcg ttagctacct ctgtgacctt 4380 gcccctgaag cccctcctcc tactctgccc cccgacatgg cacaagtcac tgtgggcccg 4440 gggctcttgg gggtttcgac cctggggccc aagaggaact ccatggttct ggatgtggcg 4500 ttcgtcctgg aaggatcgga caaaattggt gaagccgact tcaacaggag caaggagttc 4560 atggaggagg tgattcagcg gatggatgtg ggccaggaca gcatccacgt cacggtgctg 4620 cagtactcct acatggtgac cgtggagtac cccttcagcg aggcacagtc caaaggggac 4680 atcctgcagc gggtgcgaga gatccgctac cagggcggca acaggaccaa cactgggctg 4740 gccctgcggt acctctctga ccacagcttc ttggtcagcc agggtgaccg ggagcaggcg 4800 cccaacctgg tctacatggt caccggaaat cctgcctctg atgagatcaa gaggctgcct 4860 ggagacatcc aggtggtgcc cattggagtg ggccctaatg ccaacgtgca ggagctggag 4920 aggattggct ggcccaatgc ccctatcctc atccaggact ttgagacgct cccccgagag 4980 gctcctgacc tggtgctgca gaggtgctgc tccggagagg ggctgcagat ccccaccctc 5040 tcccctgcac ctgactgcag ccagcccctg gacgtgatcc ttctcctgga tggctcctcc 5100 agtttcccag cttcttattt tgatgaaatg aagagtttcg ccaaggcttt catttcaaaa 5160 gccaatatag ggcctcgtct cactcaggtg tcagtgctgc agtatggaag catcaccacc 5220 attgacgtgc catggaacgt ggtcccggag aaagcccatt tgctgagcct tgtggacgtc 5280 atgcagcggg agggaggccc cagccaaatc ggggatgcct tgggctttgc tgtgcgatac 5340 ttgacttcag aaatgcatgg tgccaggccg ggagcctcaa aggcggtggt catcctggtc 5400 acggacgtct ctgtggattc agtggatgca gcagctgatg ccgccaggtc caacagagtg 5460 acagtgttcc ctattggaat tggagatcgc tacgatgcag cccagctacg gatcttggca 5520 ggcccagcag gcgactccaa cgtggtgaag ctccagcgaa tcgaagacct ccctaccatg 5580 gtcaccttgg gcaattcctt cctccacaaa ctgtgctctg gatttgttag gatttgcatg 5640 gatgaggatg ggaatgagaa gaggcccggg gacgtctgga ccttgccaga ccagtgccac 5700 accgtgactt gccagccaga tggccagacc ttgctgaaga gtcatcgggt caactgtgac 5760 cgggggctga ggccttcgtg ccctaacagc cagtcccctg ttaaagtgga agagacctgt 5820 ggctgccgct ggacctgccc ctgygtgtgc acaggcagct ccactcggca catcgtgacc 5880 tttgatgggc agaatttcaa gctgactggc agctgttctt atgtcctatt tcaaaacaag 5940 gagcaggacc tggaggtgat tctccataat ggtgcctgca gccctggagc aaggcagggc 6000 tgcatgaaat ccatcgaggt gaagcacagt gccctctccg tcgagstgca cagtgacatg 6060 gaggtgacgg tgaatgggag actggtctct gttccttacg tgggtgggaa catggaagtc 6120 aacgtttatg gtgccatcat gcatgaggtc agattcaatc accttggtca catcttcaca 6180 ttcactccac aaaacaatga gttccaactg cagctcagcc ccaagacttt tgcttcaaag 6240 acgtatggtc tgtgtgggat ctgtgatgag aacggagcca atgacttcat gctgagggat 6300 ggcacagtca ccacagactg gaaaacactt gttcaggaat ggactgtgca gcggccaggg 6360 cagacgtgcc agcccatcct ggaggagcag tgtcttgtcc ccgacagctc ccactgccag 6420 gtcctcctct taccactgtt tgctgaatgc cacaaggtcc tggctccagc cacattctat 6480 gccatctgcc agcaggacag ttgccaccag gagcaagtgt gtgaggtgat cgcctcttat 6540 gcccacctct gtcggaccaa cggggtctgc gttgactgga ggacacctga tttctgtgct 6600 atgtcatgcc caccatctct ggtctacaac cactgtgagc atggctgtcc ccggcactgt 6660 gatggcaacg tgagctcctg tggggaccat ccctccgaag gctgtttctg ccctccagat 6720 aaagtcatgt tggaaggcag ctgtgtccct gaagaggcct gcactcagtg cattggtgag 6780 gatggagtcc agcaccagtt cctggaagcc tgggtcccgg accaccagcc ctgtcagatc 6840 tgcacatgcc tcagcgggcg gaaggtcaac tgcacaacgc agccctgccc cacggccaaa 6900 gctcccacgt gtggcctgtg tgaagtagcc cgcctccgcc agaatgcaga ccagtgctgc 6960 cccgagtatg agtgtgtgtg tgacccagtg agctgtgacc tgcccccagt gcctcactgt 7020 gaacgtggcc tccagcccac actgaccaac cctggcgagt gcagacccaa cttcacctgc 7080 gcctgcagga aggaggagtg caaaagagtg tccccaccct cctgcccccc gcaccgtttg 7140 cccacccttc ggaagaccca gtgctgtgat gagtatgagt gtgcctgcaa ctgtgtcaac 7200 tccacagtga gctgtcccct tgggtacttg gcctcaaccg ccaccaatga ctgtggctgt 7260 accacaacca cctgccttcc cgacaaggtg tgtgtccacc gaagcaccat ctaccctgtg 7320 ggccagttct gggaggaggg ctgcgatgtg tgcacctgca ccgacatgga ggatgccgtg 7380 atgggcctcc gcgtggccca gtgctcccag aagccctgtg aggacagctg tcggtcgggc 7440 ttcacttacg ttctgcatga aggcgagtgc tgtggaaggt gcctgccatc tgcctgtgag 7500 gtggtgactg gctcaccgcg gggggactcc cagtcttcct ggaagagtgt cggctcccag 7560 tgggcctccc cggagaaccc ctgcctcatc aatgagtgtg tccgagtgaa ggaggaggtc 7620 tttatacaac aaaggaacgt ctcctgcccc cagctggagg tccctgtctg cccctcgggc 7680 tttcagctga gctgtaagac ctcagcgtgc tgcccaagct gtcgctgtga gcgcatggag 7740 gcctgcatgc tcaatggcac tgtcattggg cccgggaaga ctgtgatgat cgatgtgtgc 7800 acgacctgcc gctgcatggt gcaggtgggg gtcatctctg gattcaagct ggagtgcagg 7860 aagaccacct gcaacccctg ccccctgggt tacaaggaag aaaataacac aggtgaatgt 7920 tgtgggagat gtttgcctac ggcttgcacc attcagctaa gaggaggaca gatcatgaca 7980 ctgaagcgtg atgagacgct ccaggatggc tgtgatactc acttctgcaa ggtcaatgag 8040 agaggagagt acttctggga gaagagggtc acaggctgcc caccctttga tgaacacaag 8100 tgtcttgctg agggaggtaa aattatgaaa attccaggca cctgctgtga cacatgtgag 8160 gagcctgagt gcaacgacat cactgccagg ctgcagtatg tcaaggtggg aagctgtaag 8220 tctgaagtag aggtggatat ccactactgc cagggcaaat gtgccagcaa agccatgtac 8280 tccattgaca tcaacgatgt gcaggaccag tgctcctgct gctctccgac acggacggag 8340 cccatgcagg tggccctgca ctgcaccaat ggctctgttg tgtaccatga ggttctcaat 8400 gccatggagt gcaaatgctc ccccaggaag tgcagcaagt ga 8442 <210> 129 <211> 2809 <212> PRT <213> Secuencia Artificial <220> <223> VWF humano <220> <221> rasgo_misc <222> (540)..(540) <223> Xaa puede ser cualquier aminoácido de origen natural <220> <221> rasgo_misc <222> (1944)..(1944) <223> Xaa puede ser cualquier aminoácido de origen natural <220> <221> rasgo_misc <222> (2012)..(2012) <223> Xaa puede ser cualquier aminoácido de origen natural <400> 129 Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 1 5 10 15 Leu Pro Gly Thr Leu Cys Ala Glu Gly Thr Arg Gly Arg Ser Ser Thr 20 25 30 Ala Arg Cys Ser Leu Phe Gly Ser Asp Phe Val Asn Thr Phe Asp Gly 35 40 45 Ser Met Tyr Ser Phe Ala Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Gly 50 55 60 Cys Gln Lys Arg Ser Phe Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys 65 70 75 80 Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 85 90 95 Phe Val Asn Gly Thr Val Thr Gln Gly Asp Gln Arg Val Ser Met Pro 100 105 110 Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 115 120 125 Leu Ser Gly Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 130 135 140 Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 145 150 155 160 Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Met Thr Gln 165 170 175 Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 180 185 190 Leu Ser Ser Gly Glu Gln Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser 195 200 205 Ser Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln 210 215 220 Cys Gln Leu Leu Lys Ser Thr Ser Val Phe Ala Arg Cys His Pro Leu 225 230 235 240 Val Asp Pro Glu Pro Phe Val Cys Glu Lys Thr Leu Cys Glu Cys Ala 245 250 255 Gly Gly Leu Glu Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala Arg Thr 260 265 270 Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His Ser Ala 275 280 285 Cys Ser Pro Val Cys Pro Ala Gly Met Glu Tyr Arg Gln Cys Val Ser 290 295 300 Pro Cys Ala Arg Thr Cys Gln Ser Leu His Ile Asn Glu Met Cys Gln 305 310 315 320 Glu Arg Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu Leu Asp 325 330 335 Glu Gly Leu Cys Val Glu Ser Thr Glu Cys Pro Cys Val His Ser Gly 340 345 350 Lys Arg Tyr Pro Pro Gly Thr Ser Leu Ser Arg Asp Cys Asn Thr Cys 355 360 365 Ile Cys Arg Asn Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys Pro Gly 370 375 380 Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp Asn Arg 385 390 395 400 Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg Asp Cys 405 410 415 Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys Ala Asp 420 425 430 Asp Arg Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu Pro Gly 435 440 445 Leu His Asn Ser Leu Val Lys Leu Lys His Gly Ala Gly Val Ala Met 450 455 460 Asp Gly Gln Asp Ile Gln Leu Pro Leu Leu Lys Gly Asp Leu Arg Ile 465 470 475 480 Gln His Thr Val Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu Asp Leu 485 490 495 Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu Ser Pro 500 505 510 Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn Gly Asn 515 520 525 Gln Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Xaa Glu Pro Arg Val 530 535 540 Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln Asp Leu 545 550 555 560 Gln Lys Gln His Ser Asp Pro Cys Ala Leu Asn Pro Arg Met Thr Arg 565 570 575 Phe Ser Glu Glu Ala Cys Ala Val Leu Thr Ser Pro Thr Phe Glu Ala 580 585 590 Cys His Arg Ala Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys Arg Tyr 595 600 605 Asp Val Cys Ser Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly Ala Ser 610 615 620 Tyr Ala Ala Ala Cys Ala Gly Arg Gly Val Arg Val Ala Trp Arg Glu 625 630 635 640 Pro Gly Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln Val Tyr Leu Gln 645 650 655 Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu Ser Tyr Pro Asp 660 665 670 Glu Glu Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe Cys Pro Pro Gly 675 680 685 Leu Tyr Met Asp Glu Arg Gly Asp Cys Val Pro Lys Ala Gln Cys Pro 690 695 700 Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp Ile Phe Ser Asp 705 710 715 720 His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met His Cys Thr Met 725 730 735 Ser Gly Val Pro Gly Ser Leu Leu Pro Asp Ala Val Leu Ser Ser Pro 740 745 750 Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg Pro Pro Met Val 755 760 765 Lys Leu Val Cys Pro Ala Asp Asn Leu Arg Ala Glu Gly Leu Glu Cys 770 775 780 Thr Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met Ser Met Gly Cys 785 790 795 800 Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg His Glu Asn Arg 805 810 815 Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln Gly Lys Glu Tyr 820 825 830 Ala Pro Gly Glu Thr Val Lys Ile Gly Cys Asn Thr Cys Val Cys Arg 835 840 845 Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp Ala Thr Cys Ser 850 855 860 Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly Leu Lys Tyr Leu 865 870 875 880 Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp Tyr Cys Gly Ser 885 890 895 Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Lys Gly Cys Ser His 900 905 910 Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu Val Glu Gly Gly 915 920 925 Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys Arg Pro Met Lys 930 935 940 Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg Tyr Ile Ile Leu 945 950 955 960 Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg His Leu Ser Ile 965 970 975 Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val Cys Gly Leu Cys 980 985 990 Gly Asn Phe Asp Gly Ile Gln Asn Asn Asp Leu Thr Ser Ser Asn Leu 995 1000 1005 Gln Val Glu Glu Asp Pro Val Asp Phe Gly Asn Ser Trp Lys Val 1010 1015 1020 Ser Ser Gln Cys Ala Asp Thr Arg Lys Val Pro Leu Asp Ser Ser 1025 1030 1035 Pro Ala Thr Cys His Asn Asn Ile Met Lys Gln Thr Met Val Asp 1040 1045 1050 Ser Ser Cys Arg Ile Leu Thr Ser Asp Val Phe Gln Asp Cys Asn 1055 1060 1065 Lys Leu Val Asp Pro Glu Pro Tyr Leu Asp Val Cys Ile Tyr Asp 1070 1075 1080 Thr Cys Ser Cys Glu Ser Ile Gly Asp Cys Ala Cys Phe Cys Asp 1085 1090 1095 Thr Ile Ala Ala Tyr Ala His Val Cys Ala Gln His Gly Lys Val 1100 1105 1110 Val Thr Trp Arg Thr Ala Thr Leu Cys Pro Gln Ser Cys Glu Glu 1115 1120 1125 Arg Asn Leu Arg Glu Asn Gly Tyr Glu Cys Glu Trp Arg Tyr Asn 1130 1135 1140 Ser Cys Ala Pro Ala Cys Gln Val Thr Cys Gln His Pro Glu Pro 1145 1150 1155 Leu Ala Cys Pro Val Gln Cys Val Glu Gly Cys His Ala His Cys 1160 1165 1170 Pro Pro Gly Lys Ile Leu Asp Glu Leu Leu Gln Thr Cys Val Asp 1175 1180 1185 Pro Glu Asp Cys Pro Val Cys Glu Val Ala Gly Arg Arg Phe Ala 1190 1195 1200 Ser Gly Lys Lys Val Thr Leu Asn Pro Ser Asp Pro Glu His Cys 1205 1210 1215 Gln Ile Cys His Cys Asp Val Val Asn Leu Thr Cys Glu Ala Cys 1220 1225 1230 Gln Glu Pro Gly Gly Leu Val Val Pro Pro Thr Asp Ala Pro Val 1235 1240 1245 Ser Pro Thr Thr Leu Tyr Val Glu Asp Ile Ser Glu Pro Pro Leu 1250 1255 1260 His Asp Phe Tyr Cys Ser Arg Leu Leu Asp Leu Val Phe Leu Leu 1265 1270 1275 Asp Gly Ser Ser Arg Leu Ser Glu Ala Glu Phe Glu Val Leu Lys 1280 1285 1290 Ala Phe Val Val Asp Met Met Glu Arg Leu Arg Ile Ser Gln Lys 1295 1300 1305 Trp Val Arg Val Ala Val Val Glu Tyr His Asp Gly Ser His Ala 1310 1315 1320 Tyr Ile Gly Leu Lys Asp Arg Lys Arg Pro Ser Glu Leu Arg Arg 1325 1330 1335 Ile Ala Ser Gln Val Lys Tyr Ala Gly Ser Gln Val Ala Ser Thr 1340 1345 1350 Ser Glu Val Leu Lys Tyr Thr Leu Phe Gln Ile Phe Ser Lys Ile 1355 1360 1365 Asp Arg Pro Glu Ala Ser Arg Ile Ala Leu Leu Leu Met Ala Ser 1370 1375 1380 Gln Glu Pro Gln Arg Met Ser Arg Asn Phe Val Arg Tyr Val Gln 1385 1390 1395 Gly Leu Lys Lys Lys Lys Val Ile Val Ile Pro Val Gly Ile Gly 1400 1405 1410 Pro His Ala Asn Leu Lys Gln Ile Arg Leu Ile Glu Lys Gln Ala 1415 1420 1425 Pro Glu Asn Lys Ala Phe Val Leu Ser Ser Val Asp Glu Leu Glu 1430 1435 1440 Gln Gln Arg Asp Glu Ile Val Ser Tyr Leu Cys Asp Leu Ala Pro 1445 1450 1455 Glu Ala Pro Pro Pro Thr Leu Pro Pro Asp Met Ala Gln Val Thr 1460 1465 1470 Val Gly Pro Gly Leu Leu Gly Val Ser Thr Leu Gly Pro Lys Arg 1475 1480 1485 Asn Ser Met Val Leu Asp Val Ala Phe Val Leu Glu Gly Ser Asp 1490 1495 1500 Lys Ile Gly Glu Ala Asp Phe Asn Arg Ser Lys Glu Phe Met Glu 1505 1510 1515 Glu Val Ile Gln Arg Met Asp Val Gly Gln Asp Ser Ile His Val 1520 1525 1530 Thr Val Leu Gln Tyr Ser Tyr Met Val Thr Val Glu Tyr Pro Phe 1535 1540 1545 Ser Glu Ala Gln Ser Lys Gly Asp Ile Leu Gln Arg Val Arg Glu 1550 1555 1560 Ile Arg Tyr Gln Gly Gly Asn Arg Thr Asn Thr Gly Leu Ala Leu 1565 1570 1575 Arg Tyr Leu Ser Asp His Ser Phe Leu Val Ser Gln Gly Asp Arg 1580 1585 1590 Glu Gln Ala Pro Asn Leu Val Tyr Met Val Thr Gly Asn Pro Ala 1595 1600 1605 Ser Asp Glu Ile Lys Arg Leu Pro Gly Asp Ile Gln Val Val Pro 1610 1615 1620 Ile Gly Val Gly Pro Asn Ala Asn Val Gln Glu Leu Glu Arg Ile 1625 1630 1635 Gly Trp Pro Asn Ala Pro Ile Leu Ile Gln Asp Phe Glu Thr Leu 1640 1645 1650 Pro Arg Glu Ala Pro Asp Leu Val Leu Gln Arg Cys Cys Ser Gly 1655 1660 1665 Glu Gly Leu Gln Ile Pro Thr Leu Ser Pro Ala Pro Asp Cys Ser 1670 1675 1680 Gln Pro Leu Asp Val Ile Leu Leu Leu Asp Gly Ser Ser Ser Phe 1685 1690 1695 Pro Ala Ser Tyr Phe Asp Glu Met Lys Ser Phe Ala Lys Ala Phe 1700 1705 1710 Ile Ser Lys Ala Asn Ile Gly Pro Arg Leu Thr Gln Val Ser Val 1715 1720 1725 Leu Gln Tyr Gly Ser Ile Thr Thr Ile Asp Val Pro Trp Asn Val 1730 1735 1740 Val Pro Glu Lys Ala His Leu Leu Ser Leu Val Asp Val Met Gln 1745 1750 1755 Arg Glu Gly Gly Pro Ser Gln Ile Gly Asp Ala Leu Gly Phe Ala 1760 1765 1770 Val Arg Tyr Leu Thr Ser Glu Met His Gly Ala Arg Pro Gly Ala 1775 1780 1785 Ser Lys Ala Val Val Ile Leu Val Thr Asp Val Ser Val Asp Ser 1790 1795 1800 Val Asp Ala Ala Ala Asp Ala Ala Arg Ser Asn Arg Val Thr Val 1805 1810 1815 Phe Pro Ile Gly Ile Gly Asp Arg Tyr Asp Ala Ala Gln Leu Arg 1820 1825 1830 Ile Leu Ala Gly Pro Ala Gly Asp Ser Asn Val Val Lys Leu Gln 1835 1840 1845 Arg Ile Glu Asp Leu Pro Thr Met Val Thr Leu Gly Asn Ser Phe 1850 1855 1860 Leu His Lys Leu Cys Ser Gly Phe Val Arg Ile Cys Met Asp Glu 1865 1870 1875 Asp Gly Asn Glu Lys Arg Pro Gly Asp Val Trp Thr Leu Pro Asp 1880 1885 1890 Gln Cys His Thr Val Thr Cys Gln Pro Asp Gly Gln Thr Leu Leu 1895 1900 1905 Lys Ser His Arg Val Asn Cys Asp Arg Gly Leu Arg Pro Ser Cys 1910 1915 1920 Pro Asn Ser Gln Ser Pro Val Lys Val Glu Glu Thr Cys Gly Cys 1925 1930 1935 Arg Trp Thr Cys Pro Xaa Val Cys Thr Gly Ser Ser Thr Arg His 1940 1945 1950 Ile Val Thr Phe Asp Gly Gln Asn Phe Lys Leu Thr Gly Ser Cys 1955 1960 1965 Ser Tyr Val Leu Phe Gln Asn Lys Glu Gln Asp Leu Glu Val Ile 1970 1975 1980 Leu His Asn Gly Ala Cys Ser Pro Gly Ala Arg Gln Gly Cys Met 1985 1990 1995 Lys Ser Ile Glu Val Lys His Ser Ala Leu Ser Val Glu Xaa His 2000 2005 2010 Ser Asp Met Glu Val Thr Val Asn Gly Arg Leu Val Ser Val Pro 2015 2020 2025 Tyr Val Gly Gly Asn Met Glu Val Asn Val Tyr Gly Ala Ile Met 2030 2035 2040 His Glu Val Arg Phe Asn His Leu Gly His Ile Phe Thr Phe Thr 2045 2050 2055 Pro Gln Asn Asn Glu Phe Gln Leu Gln Leu Ser Pro Lys Thr Phe 2060 2065 2070 Ala Ser Lys Thr Tyr Gly Leu Cys Gly Ile Cys Asp Glu Asn Gly 2075 2080 2085 Ala Asn Asp Phe Met Leu Arg Asp Gly Thr Val Thr Thr Asp Trp 2090 2095 2100 Lys Thr Leu Val Gln Glu Trp Thr Val Gln Arg Pro Gly Gln Thr 2105 2110 2115 Cys Gln Pro Ile Leu Glu Glu Gln Cys Leu Val Pro Asp Ser Ser 2120 2125 2130 His Cys Gln Val Leu Leu Leu Pro Leu Phe Ala Glu Cys His Lys 2135 2140 2145 Val Leu Ala Pro Ala Thr Phe Tyr Ala Ile Cys Gln Gln Asp Ser 2150 2155 2160 Cys His Gln Glu Gln Val Cys Glu Val Ile Ala Ser Tyr Ala His 2165 2170 2175 Leu Cys Arg Thr Asn Gly Val Cys Val Asp Trp Arg Thr Pro Asp 2180 2185 2190 Phe Cys Ala Met Ser Cys Pro Pro Ser Leu Val Tyr Asn His Cys 2195 2200 2205 Glu His Gly Cys Pro Arg His Cys Asp Gly Asn Val Ser Ser Cys 2210 2215 2220 Gly Asp His Pro Ser Glu Gly Cys Phe Cys Pro Pro Asp Lys Val 2225 2230 2235 Met Leu Glu Gly Ser Cys Val Pro Glu Glu Ala Cys Thr Gln Cys 2240 2245 2250 Ile Gly Glu Asp Gly Val Gln His Gln Phe Leu Glu Ala Trp Val 2255 2260 2265 Pro Asp His Gln Pro Cys Gln Ile Cys Thr Cys Leu Ser Gly Arg 2270 2275 2280 Lys Val Asn Cys Thr Thr Gln Pro Cys Pro Thr Ala Lys Ala Pro 2285 2290 2295 Thr Cys Gly Leu Cys Glu Val Ala Arg Leu Arg Gln Asn Ala Asp 2300 2305 2310 Gln Cys Cys Pro Glu Tyr Glu Cys Val Cys Asp Pro Val Ser Cys 2315 2320 2325 Asp Leu Pro Pro Val Pro His Cys Glu Arg Gly Leu Gln Pro Thr 2330 2335 2340 Leu Thr Asn Pro Gly Glu Cys Arg Pro Asn Phe Thr Cys Ala Cys 2345 2350 2355 Arg Lys Glu Glu Cys Lys Arg Val Ser Pro Pro Ser Cys Pro Pro 2360 2365 2370 His Arg Leu Pro Thr Leu Arg Lys Thr Gln Cys Cys Asp Glu Tyr 2375 2380 2385 Glu Cys Ala Cys Asn Cys Val Asn Ser Thr Val Ser Cys Pro Leu 2390 2395 2400 Gly Tyr Leu Ala Ser Thr Ala Thr Asn Asp Cys Gly Cys Thr Thr 2405 2410 2415 Thr Thr Cys Leu Pro Asp Lys Val Cys Val His Arg Ser Thr Ile 2420 2425 2430 Tyr Pro Val Gly Gln Phe Trp Glu Glu Gly Cys Asp Val Cys Thr 2435 2440 2445 Cys Thr Asp Met Glu Asp Ala Val Met Gly Leu Arg Val Ala Gln 2450 2455 2460 Cys Ser Gln Lys Pro Cys Glu Asp Ser Cys Arg Ser Gly Phe Thr 2465 2470 2475 Tyr Val Leu His Glu Gly Glu Cys Cys Gly Arg Cys Leu Pro Ser 2480 2485 2490 Ala Cys Glu Val Val Thr Gly Ser Pro Arg Gly Asp Ser Gln Ser 2495 2500 2505 Ser Trp Lys Ser Val Gly Ser Gln Trp Ala Ser Pro Glu Asn Pro 2510 2515 2520 Cys Leu Ile Asn Glu Cys Val Arg Val Lys Glu Glu Val Phe Ile 2525 2530 2535 Gln Gln Arg Asn Val Ser Cys Pro Gln Leu Glu Val Pro Val Cys 2540 2545 2550 Pro Ser Gly Phe Gln Leu Ser Cys Lys Thr Ser Ala Cys Cys Pro 2555 2560 2565 Ser Cys Arg Cys Glu Arg Met Glu Ala Cys Met Leu Asn Gly Thr 2570 2575 2580 Val Ile Gly Pro Gly Lys Thr Val Met Ile Asp Val Cys Thr Thr 2585 2590 2595 Cys Arg Cys Met Val Gln Val Gly Val Ile Ser Gly Phe Lys Leu 2600 2605 2610 Glu Cys Arg Lys Thr Thr Cys Asn Pro Cys Pro Leu Gly Tyr Lys 2615 2620 2625 Glu Glu Asn Asn Thr Gly Glu Cys Cys Gly Arg Cys Leu Pro Thr 2630 2635 2640 Ala Cys Thr Ile Gln Leu Arg Gly Gly Gln Ile Met Thr Leu Lys 2645 2650 2655 Arg Asp Glu Thr Leu Gln Asp Gly Cys Asp Thr His Phe Cys Lys 2660 2665 2670 Val Asn Glu Arg Gly Glu Tyr Phe Trp Glu Lys Arg Val Thr Gly 2675 2680 2685 Cys Pro Pro Phe Asp Glu His Lys Cys Leu Ala Glu Gly Gly Lys 2690 2695 2700 Ile Met Lys Ile Pro Gly Thr Cys Cys Asp Thr Cys Glu Glu Pro 2705 2710 2715 Glu Cys Asn Asp Ile Thr Ala Arg Leu Gln Tyr Val Lys Val Gly 2720 2725 2730 Ser Cys Lys Ser Glu Val Glu Val Asp Ile His Tyr Cys Gln Gly 2735 2740 2745 Lys Cys Ala Ser Lys Ala Met Tyr Ser Ile Asp Ile Asn Asp Val 2750 2755 2760 Gln Asp Gln Cys Ser Cys Cys Ser Pro Thr Arg Thr Glu Pro Met 2765 2770 2775 Gln Val Ala Leu His Cys Thr Asn Gly Ser Val Val Tyr His Glu 2780 2785 2790 Val Leu Asn Ala Met Glu Cys Lys Cys Ser Pro Arg Lys Cys Ser 2795 2800 2805 Lys <210> 130 <211> 36 <212> PRT <213> Secuencia Artificial <220> <223> AE36 <400> 130 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 1 5 10 15 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 20 25 30 Ser Glu Thr Pro 35 <210> 131 <211> 42 <212> PRT <213> Secuencia Artificial <220> <223> AE42 <400> 131 Gly Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 1 5 10 15 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 20 25 30 Thr Ser Gly Ser Glu Thr Pro Ala Ser Ser 35 40 <210> 132 <211> 78 <212> PRT <213> Secuencia Artificial <220> <223> AE72 <400> 132 Gly Ala Pro Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser 1 5 10 15 Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala 20 25 30 Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 35 40 45 Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr 50 55 60 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ala Ser Ser 65 70 75 <210> 133 <211> 78 <212> PRT <213> Secuencia Artificial <220> <223> AE78 <400> 133 Gly Ala Pro Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser 1 5 10 15 Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala 20 25 30 Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 35 40 45 Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr 50 55 60 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ala Ser Ser 65 70 75 <210> 134 <211> 143 <212> PRT <213> Secuencia Artificial <220> <223> AE144 <400> 134 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 1 5 10 15 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 20 25 30 Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 35 40 45 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro 50 55 60 Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly 65 70 75 80 Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 85 90 95 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 100 105 110 Ser Ala Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 115 120 125 Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 130 135 140 <210> 135 <211> 144 <212> PRT <213> Secuencia Artificial <220> <223> AE144_6B <400> 135 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser 1 5 10 15 Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 20 25 30 Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 35 40 45 Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 50 55 60 Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 65 70 75 80 Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 85 90 95 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro Ala 100 105 110 Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 115 120 125 Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 130 135 140 <210> 136 <211> 144 <212> PRT <213> Secuencia Artificial <220> <223> AG144 <400> 136 Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr 1 5 10 15 Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser Thr 20 25 30 Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro 35 40 45 Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro 50 55 60 Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 65 70 75 80 Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro 85 90 95 Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Pro 100 105 110 Ser Ala Ser Thr Gly Thr Gly Pro Gly Thr Pro Gly Ser Gly Thr Ala 115 120 125 Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 130 135 140 <210> 137 <211> 144 <212> PRT <213> Secuencia Artificial <220> <223> AG144_A <400> 137 Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Pro 1 5 10 15 Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser Thr 20 25 30 Gly Thr Gly Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 35 40 45 Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro 50 55 60 Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser 65 70 75 80 Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 85 90 95 Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Thr Pro Gly 100 105 110 Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 115 120 125 Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 130 135 140 <210> 138 <211> 288 <212> PRT <213> Secuencia Artificial <220> <223> AE288 <400> 138 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 1 5 10 15 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 20 25 30 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 35 40 45 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 50 55 60 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 65 70 75 80 Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 85 90 95 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 100 105 110 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr 115 120 125 Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 130 135 140 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 145 150 155 160 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro 165 170 175 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 180 185 190 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro 195 200 205 Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr 210 215 220 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 225 230 235 240 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro 245 250 255 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 260 265 270 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 275 280 285 <210> 139 <211> 288 <212> PRT <213> Secuencia Artificial <220> <223> AE288_2 <400> 139 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 1 5 10 15 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 20 25 30 Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 35 40 45 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 50 55 60 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 65 70 75 80 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 85 90 95 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 100 105 110 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 115 120 125 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 130 135 140 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 145 150 155 160 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 165 170 175 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 180 185 190 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 195 200 205 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 210 215 220 Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 225 230 235 240 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala 245 250 255 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 260 265 270 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 275 280 285 <210> 140 <211> 288 <212> PRT <213> Secuencia Artificial <220> <223> AG288 <400> 140 Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser 1 5 10 15 Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr 20 25 30 Ala Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser 35 40 45 Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser 50 55 60 Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr 65 70 75 80 Ala Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser 85 90 95 Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser 100 105 110 Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser 115 120 125 Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser 130 135 140 Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser 145 150 155 160 Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser 165 170 175 Thr Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly 180 185 190 Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser 195 200 205 Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly 210 215 220 Ala Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly 225 230 235 240 Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser 245 250 255 Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Thr Pro Gly Ser Gly Thr 260 265 270 Ala Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser 275 280 285 <210> 141 <211> 576 <212> PRT <213> Secuencia Artificial <220> <223> AE576 <400> 141 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 1 5 10 15 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 20 25 30 Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 35 40 45 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 50 55 60 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 65 70 75 80 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 85 90 95 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala 100 105 110 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 115 120 125 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 130 135 140 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala 145 150 155 160 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu 165 170 175 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 180 185 190 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 195 200 205 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 210 215 220 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 225 230 235 240 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 245 250 255 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 260 265 270 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 275 280 285 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 290 295 300 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 305 310 315 320 Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 325 330 335 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 340 345 350 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 355 360 365 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 370 375 380 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 385 390 395 400 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 405 410 415 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 420 425 430 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 435 440 445 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 450 455 460 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 465 470 475 480 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 485 490 495 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 500 505 510 Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 515 520 525 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala 530 535 540 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 545 550 555 560 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 565 570 575 <210> 142 <211> 576 <212> PRT <213> Secuencia Artificial <220> <223> AG576 <400> 142 Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser 1 5 10 15 Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser 20 25 30 Thr Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly 35 40 45 Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser 50 55 60 Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser 65 70 75 80 Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser 85 90 95 Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Thr Pro 100 105 110 Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro Gly Thr Ser 115 120 125 Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser 130 135 140 Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser 145 150 155 160 Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Thr Pro Gly Ser Gly Thr 165 170 175 Ala Ser Ser Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser 180 185 190 Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser 195 200 205 Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly 210 215 220 Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser 225 230 235 240 Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Thr Pro 245 250 255 Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly 260 265 270 Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser 275 280 285 Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser 290 295 300 Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser 305 310 315 320 Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser 325 330 335 Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser 340 345 350 Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser 355 360 365 Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser 370 375 380 Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Thr Pro 385 390 395 400 Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly 405 410 415 Ala Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser 420 425 430 Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Thr Pro 435 440 445 Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly 450 455 460 Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser 465 470 475 480 Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser 485 490 495 Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser 500 505 510 Ser Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser 515 520 525 Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser 530 535 540 Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser 545 550 555 560 Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser 565 570 575 <210> 143 <211> 864 <212> PRT <213> Secuencia Artificial <220> <223> AE864 <400> 143 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 1 5 10 15 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 20 25 30 Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 35 40 45 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 50 55 60 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 65 70 75 80 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 85 90 95 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala 100 105 110 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 115 120 125 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 130 135 140 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala 145 150 155 160 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu 165 170 175 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 180 185 190 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 195 200 205 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 210 215 220 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 225 230 235 240 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 245 250 255 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 260 265 270 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 275 280 285 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 290 295 300 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 305 310 315 320 Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 325 330 335 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 340 345 350 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 355 360 365 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 370 375 380 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 385 390 395 400 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 405 410 415 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 420 425 430 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 435 440 445 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 450 455 460 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 465 470 475 480 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 485 490 495 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 500 505 510 Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 515 520 525 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala 530 535 540 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 545 550 555 560 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 565 570 575 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 580 585 590 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 595 600 605 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 610 615 620 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 625 630 635 640 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 645 650 655 Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 660 665 670 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 675 680 685 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr 690 695 700 Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 705 710 715 720 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 725 730 735 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro 740 745 750 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 755 760 765 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro 770 775 780 Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr 785 790 795 800 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 805 810 815 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro 820 825 830 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 835 840 845 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 850 855 860 <210> 144 <211> 864 <212> PRT <213> Secuencia Artificial <220> <223> AG864 <400> 144 Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Pro 1 5 10 15 Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser Thr 20 25 30 Gly Thr Gly Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 35 40 45 Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro 50 55 60 Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser 65 70 75 80 Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 85 90 95 Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Thr Pro Gly 100 105 110 Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 115 120 125 Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 130 135 140 Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr 145 150 155 160 Pro Ser Gly Ala Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 165 170 175 Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 180 185 190 Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro 195 200 205 Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser Thr 210 215 220 Gly Thr Gly Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 225 230 235 240 Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ala Ser Pro 245 250 255 Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 260 265 270 Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 275 280 285 Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro 290 295 300 Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 305 310 315 320 Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 325 330 335 Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Thr Pro Gly 340 345 350 Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 355 360 365 Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 370 375 380 Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Thr 385 390 395 400 Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 405 410 415 Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 420 425 430 Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr 435 440 445 Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 450 455 460 Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 465 470 475 480 Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro 485 490 495 Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 500 505 510 Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 515 520 525 Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro 530 535 540 Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 545 550 555 560 Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 565 570 575 Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr 580 585 590 Pro Ser Gly Ala Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala 595 600 605 Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 610 615 620 Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr 625 630 635 640 Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 645 650 655 Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro 660 665 670 Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro 675 680 685 Gly Thr Ser Ser Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala 690 695 700 Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 705 710 715 720 Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro 725 730 735 Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser 740 745 750 Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 755 760 765 Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro 770 775 780 Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser 785 790 795 800 Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro 805 810 815 Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr 820 825 830 Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 835 840 845 Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 850 855 860 <210> 145 <211> 72 <212> PRT <213> Secuencia Artificial <220> <223> XTEN_AE72_2A_1 <400> 145 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly 1 5 10 15 Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly 20 25 30 Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 35 40 45 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu 50 55 60 Pro Ser Glu Gly Ser Ala Pro Gly 65 70 <210> 146 <211> 72 <212> PRT <213> Secuencia Artificial <220> <223> XTEN_AE72_2A_2 <400> 146 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 1 5 10 15 Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 20 25 30 Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 35 40 45 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser 50 55 60 Ala Thr Pro Glu Ser Gly Pro Gly 65 70 <210> 147 <211> 72 <212> PRT <213> Secuencia Artificial <220> <223> XTEN_AE72_3B_1 <400> 147 Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser 1 5 10 15 Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 20 25 30 Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 35 40 45 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu 50 55 60 Pro Ser Glu Gly Ser Ala Pro Gly 65 70 <210> 148 <211> 72 <212> PRT <213> Secuencia Artificial <220> <223> XTEN_AE72_3B_2 <400> 148 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu 1 5 10 15 Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 20 25 30 Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 35 40 45 Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu 50 55 60 Pro Ser Glu Gly Ser Ala Pro Gly 65 70 <210> 149 <211> 72 <212> PRT <213> Secuencia Artificial <220> <223> XTEN_AE72_4A_2 <400> 149 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly 1 5 10 15 Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser 20 25 30 Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 35 40 45 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu 50 55 60 Pro Ser Glu Gly Ser Ala Pro Gly 65 70 <210> 150 <211> 72 <212> PRT <213> Secuencia Artificial <220> <223> XTEN_AE72_5A_2 <400> 150 Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser 1 5 10 15 Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 20 25 30 Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 35 40 45 Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly 50 55 60 Ser Pro Thr Ser Thr Glu Glu Gly 65 70 <210> 151 <211> 72 <212> PRT <213> Secuencia Artificial <220> <223> XTEN_AE72_6B_1 <400> 151 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser 1 5 10 15 Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 20 25 30 Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 35 40 45 Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 50 55 60 Thr Ser Gly Ser Glu Thr Pro Gly 65 70 <210> 152 <211> 72 <212> PRT <213> Secuencia Artificial <220> <223> XTEN_AE72_6B_2 <400> 152 Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu 1 5 10 15 Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 20 25 30 Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 35 40 45 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu 50 55 60 Pro Ser Glu Gly Ser Ala Pro Gly 65 70 <210> 153 <211> 72 <212> PRT <213> Secuencia Artificial <220> <223> XTEN_AE72_1A_1 <400> 153 Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser 1 5 10 15 Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 20 25 30 Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 35 40 45 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu 50 55 60 Pro Ser Glu Gly Ser Ala Pro Gly 65 70 <210> 154 <211> 72 <212> PRT <213> Secuencia Artificial <220> <223> XTEN_AE72_1A_2 <400> 154 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 1 5 10 15 Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 20 25 30 Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 35 40 45 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu 50 55 60 Pro Ser Glu Gly Ser Ala Pro Gly 65 70 <210> 155 <211> 144 <212> PRT <213> Secuencia Artificial <220> <223> XTEN_AE144_1A <400> 155 Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser 1 5 10 15 Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 20 25 30 Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 35 40 45 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu 50 55 60 Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 65 70 75 80 Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 85 90 95 Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly 100 105 110 Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu 115 120 125 Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 130 135 140 <210> 156 <211> 150 <212> PRT <213> Secuencia Artificial <220> <223> AE150 <400> 156 Gly Ala Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 1 5 10 15 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 20 25 30 Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 35 40 45 Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 50 55 60 Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 65 70 75 80 Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 85 90 95 Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 100 105 110 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 115 120 125 Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 130 135 140 Ser Ala Pro Ala Ser Ser 145 150 <210> 157 <211> 150 <212> PRT <213> Secuencia Artificial <220> <223> G150 <400> 157 Gly Ala Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly 1 5 10 15 Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro Ser 20 25 30 Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly 35 40 45 Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly 50 55 60 Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Thr Pro 65 70 75 80 Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly 85 90 95 Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly 100 105 110 Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Thr Pro Gly Ser 115 120 125 Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr 130 135 140 Gly Ser Pro Ala Ser Ser 145 150 <210> 158 <211> 294 <212> PRT <213> Secuencia Artificial <220> <223> AE294 <400> 158 Gly Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 1 5 10 15 Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 20 25 30 Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 35 40 45 Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 50 55 60 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly 65 70 75 80 Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu 85 90 95 Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 100 105 110 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly 115 120 125 Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser 130 135 140 Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 145 150 155 160 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser 165 170 175 Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 180 185 190 Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 195 200 205 Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly 210 215 220 Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly 225 230 235 240 Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 245 250 255 Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 260 265 270 Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 275 280 285 Ser Ala Pro Ala Ser Ser 290 <210> 159 <211> 294 <212> PRT <213> Secuencia Artificial <220> <223> AG294 <400> 159 Gly Ala Pro Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 1 5 10 15 Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Thr Pro Gly 20 25 30 Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 35 40 45 Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 50 55 60 Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Thr Pro Gly 65 70 75 80 Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 85 90 95 Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 100 105 110 Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro 115 120 125 Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser 130 135 140 Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 145 150 155 160 Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro 165 170 175 Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser Thr 180 185 190 Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 195 200 205 Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Thr 210 215 220 Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser Thr 225 230 235 240 Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 245 250 255 Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Thr Pro Gly 260 265 270 Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 275 280 285 Thr Gly Ser Ala Ser Ser 290 <210> 160 <211> 1016 <212> PRT <213> Secuencia Artificial <220> <223> FIX-Conector-Albúmina <400> 160 Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg 1 5 10 15 Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe 20 25 30 Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly 35 40 45 Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp 50 55 60 Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys 65 70 75 80 Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu 85 90 95 Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr 100 105 110 Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val 115 120 125 Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr 130 135 140 Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu 145 150 155 160 Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn 165 170 175 Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe 180 185 190 Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly 195 200 205 Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu 210 215 220 Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu 225 230 235 240 Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His 245 250 255 His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu 260 265 270 Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile 275 280 285 Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser 290 295 300 Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala 305 310 315 320 Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys 325 330 335 Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly 340 345 350 Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro 355 360 365 His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser 370 375 380 Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys 385 390 395 400 Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr Pro 405 410 415 Val Ser Gln Thr Ser Lys Leu Thr Arg Ala Glu Thr Val Phe Pro Asp 420 425 430 Val Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 435 440 445 Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 450 455 460 Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 465 470 475 480 Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 485 490 495 Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 500 505 510 Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 515 520 525 Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 530 535 540 Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 545 550 555 560 His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 565 570 575 Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 580 585 590 Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 595 600 605 Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 610 615 620 Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 625 630 635 640 Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 645 650 655 Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 660 665 670 Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 675 680 685 Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 690 695 700 Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 705 710 715 720 His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 725 730 735 Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 740 745 750 Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 755 760 765 Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 770 775 780 Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Phe Cys 785 790 795 800 Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln 805 810 815 Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr 820 825 830 Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln 835 840 845 Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val 850 855 860 Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala 865 870 875 880 Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu 885 890 895 Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu 900 905 910 Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr 915 920 925 Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile 930 935 940 Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu 945 950 955 960 Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys 965 970 975 Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala 980 985 990 Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala 995 1000 1005 Ala Ser Gln Ala Ala Leu Gly Leu 1010 1015 <210> 161 <211> 424 <212> PRT <213> Secuencia Artificial <220> <223> FIX <400> 161 Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg 1 5 10 15 Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe 20 25 30 Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly 35 40 45 Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp 50 55 60 Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys 65 70 75 80 Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu 85 90 95 Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr 100 105 110 Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val 115 120 125 Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr 130 135 140 Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu 145 150 155 160 Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn 165 170 175 Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe 180 185 190 Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly 195 200 205 Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu 210 215 220 Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu 225 230 235 240 Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His 245 250 255 His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu 260 265 270 Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile 275 280 285 Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser 290 295 300 Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala 305 310 315 320 Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys 325 330 335 Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly 340 345 350 Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro 355 360 365 His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser 370 375 380 Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys 385 390 395 400 Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr Pro 405 410 415 Val Ser Gln Thr Ser Lys Leu Thr 420 <210> 162 <211> 9 <212> PRT <213> Secuencia Artificial <220> <223> Conector <400> 162 Arg Ala Glu Thr Val Phe Pro Asp Val 1 5 <210> 163 <211> 585 <212> PRT <213> Secuencia Artificial <220> <223> Albúmina <400> 163 Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 1 5 10 15 Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 20 25 30 Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 35 40 45 Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 50 55 60 Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 65 70 75 80 Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 85 90 95 Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 100 105 110 Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 115 120 125 Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 130 135 140 Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 145 150 155 160 Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 165 170 175 Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 180 185 190 Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 195 200 205 Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 210 215 220 Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 225 230 235 240 Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 245 250 255 Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 260 265 270 Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 275 280 285 Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 290 295 300 Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 305 310 315 320 Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 325 330 335 Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 340 345 350 Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 355 360 365 Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 370 375 380 Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 385 390 395 400 Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 405 410 415 Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 420 425 430 Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 435 440 445 Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 450 455 460 Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 465 470 475 480 Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 485 490 495 Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 500 505 510 Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 515 520 525 Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 530 535 540 Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 545 550 555 560 Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 565 570 575 Ala Ala Ser Gln Ala Ala Leu Gly Leu 580 585 <210> 164 <211> 763 <212> PRT <213> Secuencia Artificial <220> <223> FIX(XTEN)-Fc <400> 164 Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 1 5 10 15 Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 20 25 30 Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 35 40 45 Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 50 55 60 Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 65 70 75 80 Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 85 90 95 Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 100 105 110 Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys 115 120 125 Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe 130 135 140 Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 145 150 155 160 Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 165 170 175 Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 180 185 190 Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 195 200 205 Thr Ile Leu Asp Gly Pro Ser Pro Gly Ser Pro Thr Ser Thr Glu Glu 210 215 220 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 225 230 235 240 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 245 250 255 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 260 265 270 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ala Ser Ser 275 280 285 Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe Thr Arg Val Val 290 295 300 Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp Gln Val Val Leu 305 310 315 320 Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile Val Asn Glu Lys 325 330 335 Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly Val Lys Ile Thr 340 345 350 Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu His Thr Glu Gln 355 360 365 Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn Tyr Asn Ala Ala 370 375 380 Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu Leu Asp Glu Pro 385 390 395 400 Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile Ala Asp Lys Glu 405 410 415 Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr Val Ser Gly Trp 420 425 430 Gly Arg Val Phe His Lys Gly Arg Ser Ala Leu Val Leu Gln Tyr Leu 435 440 445 Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Leu Ser Thr Lys Phe 450 455 460 Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His Glu Gly Gly Arg 465 470 475 480 Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val Thr Glu Val Glu 485 490 495 Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly Glu Glu Cys Ala 500 505 510 Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser Arg Tyr Val Asn 515 520 525 Trp Ile Lys Glu Lys Thr Lys Leu Thr Asp Lys Thr His Thr Cys Pro 530 535 540 Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 545 550 555 560 Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 565 570 575 Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 580 585 590 Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 595 600 605 Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 610 615 620 Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 625 630 635 640 Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 645 650 655 Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 660 665 670 Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 675 680 685 Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 690 695 700 Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 705 710 715 720 Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 725 730 735 Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 740 745 750 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 755 760 <210> 165 <211> 712 <212> PRT <213> Secuencia Artificial <220> <223> FIX-FXIa-AE288 <400> 165 Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg 1 5 10 15 Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe 20 25 30 Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly 35 40 45 Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp 50 55 60 Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys 65 70 75 80 Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu 85 90 95 Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr 100 105 110 Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val 115 120 125 Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr 130 135 140 Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu 145 150 155 160 Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn 165 170 175 Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe 180 185 190 Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly 195 200 205 Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu 210 215 220 Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu 225 230 235 240 Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His 245 250 255 His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu 260 265 270 Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile 275 280 285 Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser 290 295 300 Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala 305 310 315 320 Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys 325 330 335 Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly 340 345 350 Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro 355 360 365 His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser 370 375 380 Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys 385 390 395 400 Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr Gly 405 410 415 Lys Leu Thr Arg Ala Glu Thr Gly Gly Thr Ser Glu Ser Ala Thr Pro 420 425 430 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 435 440 445 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 450 455 460 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 465 470 475 480 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 485 490 495 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 500 505 510 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 515 520 525 Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 530 535 540 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala 545 550 555 560 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu 565 570 575 Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 580 585 590 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu 595 600 605 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 610 615 620 Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 625 630 635 640 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr 645 650 655 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 660 665 670 Gly Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 675 680 685 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 690 695 700 Glu Pro Ser Glu Gly Ser Ala Pro 705 710 <210> 166 <211> 944 <212> PRT <213> Secuencia Artificial <220> <223> FIX-Fc-Fc <400> 166 Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 1 5 10 15 Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 20 25 30 Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 35 40 45 Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 50 55 60 Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 65 70 75 80 Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 85 90 95 Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 100 105 110 Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys 115 120 125 Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe 130 135 140 Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 145 150 155 160 Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 165 170 175 Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 180 185 190 Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 195 200 205 Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 210 215 220 Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp 225 230 235 240 Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile 245 250 255 Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly 260 265 270 Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu 275 280 285 His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn 290 295 300 Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu 305 310 315 320 Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 325 330 335 Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr 340 345 350 Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala Leu Val 355 360 365 Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Arg 370 375 380 Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His 385 390 395 400 Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val 405 410 415 Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly 420 425 430 Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 435 440 445 Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr Asp Lys Thr 450 455 460 His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 465 470 475 480 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 485 490 495 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 500 505 510 Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 515 520 525 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 530 535 540 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 545 550 555 560 Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 565 570 575 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 580 585 590 Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 595 600 605 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 610 615 620 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 625 630 635 640 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 645 650 655 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 660 665 670 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 675 680 685 Arg Arg Arg Arg Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 690 695 700 Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Arg Arg Arg Asp Lys Thr 705 710 715 720 His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 725 730 735 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 740 745 750 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 755 760 765 Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 770 775 780 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 785 790 795 800 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 805 810 815 Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 820 825 830 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 835 840 845 Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 850 855 860 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 865 870 875 880 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 885 890 895 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 900 905 910 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 915 920 925 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 930 935 940 <210> 167 <211> 383 <212> ADN <213> Secuencia Artificial <220> <223> Parvovirus B19 KY940273.1 <400> 167 ccaaatcaga tgccgccggt cgccgccggt aggcgggact tccggtacaa gatggcggac 60 aattacgtca tttcctgtga cgtcatttcc tgtgacgtca cttccggtgg gcgggacttc 120 cggaattagg gttggctctg ggccagcttg cttggggttg ccttgacact aagacaagcg 180 gcgcgccgct tgatcttagt ggcacgtcaa ccccaagcgc tggcccagag ccaaccctaa 240 ttccggaagt cccgcccacc ggaagtgacg tcacaggaaa tgacgtcaca ggaaatgacg 300 taattgtccg ccatcttgta ccggaagtcc cgcctaccgg cggcgaccgg cggcatctga 360 tttggtgtct tcttttaaat ttt 383 <210> 168 <211> 248 <212> ADN <213> Secuencia Artificial <220> <223> Parvorius B19 d135 <400> 168 ctctgggcca gcttgcttgg ggttgccttg acactaagac aagcggcgcg ccgcttgatc 60 ttagtggcac gtcaacccca agcgctggcc cagagccaac cctaattccg gaagtcccgc 120 ccaccggaag tgacgtcaca ggaaatgacg tcacaggaaa tgacgtaatt gtccgccatc 180 ttgtaccgga agtcccgcct accggcggcg accggcggca tctgatttgg tgtcttcttt 240 taaatttt 248 <210> 169 <211> 129 <212> ADN <213> Secuencia Artificial <220> <223> Parvovirus v1 AAV2 <400> 169 cggcgcgccg cttgatctta gtggcacgtc aaccagcgct ggcccagagc caaccctaat 60 tccggaagtc ctcagtccgc catcttgccc gcctaccggc ggcgaccggc ggcatcattt 120 ggtgttctt 129 <210> 170 <211> 113 <212> ADN <213> Secuencia Artificial <220> <223> Parvovirus V2 <400> 170 ctctgggcca gcttgcttgg ggttgccttg acactaagac aagcggcgcg ccgcttgatc 60 ttagtggcac gtcaacccca agcgctggcc cagagtgtct tcttttaaat ttt 113 <210> 171 <211> 340 <212> ADN <213> Secuencia Artificial <220> <223> Parvovirus V3 <400> 171 caaatcagat gccgccggtc gccgccggta ggcgggactt ccggtacaag atggcggaca 60 attacgtcat ttcctgtgac gtatttcctg tgacgtactt ccggtggcgg gacttccgga 120 attttggctc tgggccagct tgcttggggt tgccttgacc aagcgcgcgc cgcttgatca 180 ccccaagcgc tggcccagag ccacctaacc ggaagtcccc ccaccggaag tgacgtcaca 240 ggaaagacgt cacaggaagt aattgtccgc catcttgtac cggaagtccc gcaccggcgg 300 cgaccggcgg catctgattt ggtgtcttct tttaaatttt 340 <210> 172 <211> 444 <212> ADN <213> Secuencia Artificial <220> <223> Parvovirus U25749.1 <400> 172 ctcattggag ggttcgttcg ttcgaaccag ccaatcaggg gagggggaag tgacgcaagt 60 tccggtcaca tgcttccggt gacgcacatc cggtgacgta gttccggtca cgtgcttcct 120 gtcacgtgtt tccggtcacg tgacttccgg tcatgtgact tccggtgacg tgtttccggc 180 tgttaggttg accacgcgca tgccgcgcgg tcagcccaat agttaagccg gaaacacgtc 240 accggaagtc acatgaccgg aagtcacgtg accggaaaca cgtgacagga agcacgtgac 300 cggaactacg tcaccggatg tgcgtcaccg gaagcatgtg accggaactt gcgtcacttc 360 cccctcccct gattggctgg ttcgaacgaa cgaaccctcc aatgagactc aaggacaaga 420 ggatattttg cgcgccagga agtg 444 <210> 173 <211> 282 <212> ADN <213> Secuencia Artificial <220> <223> Parvovirus GPV AAV2 V1 <400> 173 cggtgacgtg tttccggctg ttaggttgac cacgcgcatg ccgcgcggtc agcccaatag 60 ttaagccgga aacacgtcac cggaagtcac atgaccggaa gtcacgtgac cggaaacacg 120 tgacaggaag cacgtgaccg gaactacgtc accggatgtg cgtcaccgga agcatgtgac 180 cggaacttgc gtcacttccc cctcccctga ttggctggtt cgaacgaacg aaccctccaa 240 tgagactcaa ggacaagagg atattttgcg cgccaggaag tg 282 <210> 174 <211> 145 <212> ADN <213> Secuencia Artificial <220> <223> Parvovirus GPV AAV2 V1 <400> 174 ttgaccacgc gcatgccgcg cggtcagccc aatagttaag ccgggtgacc acacgtgaca 60 ggaagcacgg gatgtgcgtc accggaagca gtgaccgggc tggttcgaac gaacgaaccc 120 tccaactcaa ggacaagagg atatt 145 <210> 175 <211> 120 <212> ADN <213> Secuencia Artificial <220> <223> Parvovirus GPV V2 <400> 175 cggtgacgtg tttccggctg ttaggttgac cacgcgcatg ccgcgcggtc agcccaatag 60 ttaagccgga aacacgtcac cgactcaagg acaagaggat attttgcgcg ccaggaagtg 120 <210> 176 <211> 102 <212> ADN <213> Secuencia Artificial <220> <223> Parvovirus GPV V3 <400> 176 gggaacaatc aggggaagtg accggtgacg tcatgtaact tgcgtcactt cccgttcgaa 60 cgaacgaacg agactcaagg acaagaggcg cgccaggaag tg 102 <210> 177 <211> 145 <212> ADN <213> Secuencia Artificial <220> <223> Parvovirus AAV2 NC_001401.2 <400> 177 ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc 60 cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg 120 gccaactcca tcactagggg ttcct 145 <210> 178 <211> 130 <212> ADN <213> Secuencia Artificial <220> <223> Parvovirus Gtx <400> 178 ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt 60 ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact 120 aggggttcct 130 <210> 179 <211> 6762 <212> ADN <213> Secuencia Artificial <220> <223> Construcción B19-FVIII <400> 179 ctctgggcca gcttgcttgg ggttgccttg acactaagac aagcggcgcg ccgcttgatc 60 ttagtggcac gtcaacccca agcgctggcc cagagccaac cctaattccg gaagtcccgc 120 ccaccggaag tgacgtcaca ggaaatgacg tcacaggaaa tgacgtaatt gtccgccatc 180 ttgtaccgga agtcccgcct accggcggcg accggcggca tctgatttgg tgtcttcttt 240 taaattttgc ggcaattcag tcgataacta taacggtcct aaggtagcga tttaaatacg 300 cgctctctta aggtagcccc gggacgcgtc aattgagatc tggatccggt accgaattcg 360 cggccgcctc gacgactagc gtttaattaa acgcgtgtct gtctgcacat ttcgtagagc 420 gagtgttccg atactctaat ctccctaggc aaggttcata tttgtgtagg ttacttattc 480 tccttttgtt gactaagtca ataatcagaa tcagcaggtt tggagtcagc ttggcaggga 540 tcagcagcct gggttggaag gagggggtat aaaagcccct tcaccaggag aagccgtcac 600 acagatccac aagctcctga ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt 660 acgggttatg gcccttgcgt gccttgaatt actgacactg acatccactt tttctttttc 720 tccacagcta gcgccaccat gcagattgag ctgtccactt gtttcttcct gtgcctcctg 780 cgcttctgtt tctccgccac tcgccggtac taccttggag ccgtggagct ttcatgggac 840 tacatgcaga gcgacctggg cgaactcccc gtggatgcca gattcccccc ccgcgtgcca 900 aagtccttcc cctttaacac ctccgtggtg tacaagaaaa ccctctttgt cgagttcact 960 gaccacctgt tcaacatcgc caagccgcgc ccaccttgga tgggcctcct gggaccgacc 1020 attcaagctg aagtgtacga caccgtggtg atcaccctga agaacatggc gtcccacccc 1080 gtgtccctgc atgcggtcgg agtgtcctac tggaaggcct ccgaaggagc tgagtacgac 1140 gaccagacta gccagcggga aaaggaggac gataaagtgt tcccgggcgg ctcgcatact 1200 tacgtgtggc aagtcctgaa ggaaaacgga cctatggcat ccgatcctct gtgcctgact 1260 tactcctacc tttcccatgt ggacctcgtg aaggacctga acagcgggct gattggtgca 1320 cttctcgtgt gccgcgaagg ttcgctcgct aaggaaaaga cccagaccct ccataagttc 1380 atccttttgt tcgctgtgtt cgatgaagga aagtcatggc attccgaaac taagaactcg 1440 ctgatgcagg accgggatgc cgcctcagcc cgcgcctggc ctaaaatgca tacagtcaac 1500 ggatacgtga atcggtcact gcccgggctc atcggttgtc acagaaagtc cgtgtactgg 1560 cacgtcatcg gcatgggcac tacgcctgaa gtgcactcca tcttcctgga agggcacacc 1620 ttcctcgtgc gcaaccaccg ccaggcctct ctggaaatct ccccgattac ctttctgacc 1680 gcccagactc tgctcatgga cctggggcag ttccttctct tctgccacat ctccagccat 1740 cagcacgacg gaatggaggc ctacgtgaag gtggactcat gcccggaaga acctcagttg 1800 cggatgaaga acaacgagga ggccgaggac tatgacgacg atttgactga ctccgagatg 1860 gacgtcgtgc ggttcgatga cgacaacagc cccagcttca tccagattcg cagcgtggcc 1920 aagaagcacc ccaaaacctg ggtgcactac atcgcggccg aggaagaaga ttgggactac 1980 gccccgttgg tgctggcacc cgatgaccgg tcgtacaagt cccagtatct gaacaatggt 2040 ccgcagcgga ttggcagaaa gtacaagaaa gtgcggttca tggcgtacac tgacgaaacg 2100 tttaagaccc gggaggccat tcaacatgag agcggcattc tgggaccact gctgtacgga 2160 gaggtcggcg ataccctgct catcatcttc aaaaaccagg cctcccggcc ttacaacatc 2220 taccctcacg gaatcaccga cgtgcggcca ctctactcgc ggcgcctgcc gaagggcgtc 2280 aagcacctga aagacttccc tatcctgccg ggcgaaatct tcaagtataa gtggaccgtc 2340 accgtggagg acgggcccac caagagcgat cctaggtgtc tgactcggta ctactccagc 2400 ttcgtgaaca tggaacggga cctggcatcg ggactcattg gaccgctgct gatctgctac 2460 aaagagtcgg tggatcaacg cggcaaccag atcatgtccg acaagcgcaa cgtgatcctg 2520 ttctccgtgt ttgatgaaaa cagatcctgg tacctcactg aaaacatcca gaggttcctc 2580 ccaaaccccg caggagtgca actggaggac cctgagtttc aggcctcgaa tatcatgcac 2640 tcgattaacg gttacgtgtt cgactcgctg caactgagcg tgtgcctcca tgaagtcgct 2700 tactggtaca ttctgtccat cggcgcccag actgacttcc tgagcgtgtt cttttccggt 2760 tacaccttta agcacaagat ggtgtacgaa gataccctga ccctgttccc tttctccggc 2820 gaaacggtgt tcatgtcgat ggagaacccg ggtctgtgga ttctgggatg ccacaacagc 2880 gactttcgga accgcggaat gactgccctg ctgaaggtgt cctcatgcga caagaacacc 2940 ggagactact acgaggactc ctacgaggat atctcagcct acctcctgtc caagaacaac 3000 gcgatcgagc cgcgcagctt cagccagaac ggcgcgccaa catcagagag cgccacccct 3060 gaaagtggtc ccgggagcga gccagccaca tctgggtcgg aaacgccagg cacaagtgag 3120 tctgcaactc ccgagtccgg acctggctcc gagcctgcca ctagcggctc cgagactccg 3180 ggaacttccg agagcgctac accagaaagc ggacccggaa ccagtaccga acctagcgag 3240 ggctctgctc cgggcagccc agccggctct cctacatcca cggaggaggg cacttccgaa 3300 tccgccaccc cggagtcagg gccaggatct gaacccgcta cctcaggcag tgagacgcca 3360 ggaacgagcg agtccgctac accggagagt gggccaggga gccctgctgg atctcctacg 3420 tccactgagg aagggtcacc agcgggctcg cccaccagca ctgaagaagg tgcctcgagc 3480 ccgcctgtgc tgaagaggca ccagcgagaa attacccgga ccaccctcca atcggatcag 3540 gaggaaatcg actacgacga caccatctcg gtggaaatga agaaggaaga tttcgatatc 3600 tacgacgagg acgaaaatca gtcccctcgc tcattccaaa agaaaactag acactacttt 3660 atcgccgcgg tggaaagact gtgggactat ggaatgtcat ccagccctca cgtccttcgg 3720 aaccgggccc agagcggatc ggtgcctcag ttcaagaaag tggtgttcca ggagttcacc 3780 gacggcagct tcacccagcc gctgtaccgg ggagaactga acgaacacct gggcctgctc 3840 ggtccctaca tccgcgcgga agtggaggat aacatcatgg tgaccttccg taaccaagca 3900 tccagacctt actccttcta ttcctccctg atctcatacg aggaggacca gcgccaaggc 3960 gccgagcccc gcaagaactt cgtcaagccc aacgagacta agacctactt ctggaaggtc 4020 caacaccata tggccccgac caaggatgag tttgactgca aggcctgggc ctacttctcc 4080 gacgtggacc ttgagaagga tgtccattcc ggcctgatcg ggccgctgct cgtgtgtcac 4140 accaacaccc tgaacccagc gcatggacgc caggtcaccg tccaggagtt tgctctgttc 4200 ttcaccattt ttgacgaaac taagtcctgg tacttcaccg agaatatgga gcgaaactgt 4260 agagcgccct gcaatatcca gatggaagat ccgactttca aggagaacta tagattccac 4320 gccatcaacg ggtacatcat ggatactctg ccggggctgg tcatggccca ggatcagagg 4380 attcggtggt acttgctgtc aatgggatcg aacgaaaaca ttcactccat tcacttctcc 4440 ggtcacgtgt tcactgtgcg caagaaggag gagtacaaga tggcgctgta caatctgtac 4500 cccggggtgt tcgaaactgt ggagatgctg ccgtccaagg ccggcatctg gagagtggag 4560 tgcctgatcg gagagcacct ccacgcgggg atgtccaccc tcttcctggt gtactcgaat 4620 aagtgccaga ccccgctggg catggcctcg ggccacatca gagacttcca gatcacagca 4680 agcggacaat acggccaatg ggcgccgaag ctggcccgct tgcactactc cggatcgatc 4740 aacgcatggt ccaccaagga accgttctcg tggattaagg tggacctcct ggcccctatg 4800 attatccacg gaattaagac ccagggcgcc aggcagaagt tctcctccct gtacatctcg 4860 caattcatca tcatgtacag cctggacggg aagaagtggc agacttacag gggaaactcc 4920 accggcaccc tgatggtctt tttcggcaac gtggattcct ccggcattaa gcacaacatc 4980 ttcaacccac cgatcatagc cagatatatt aggctccacc ccactcacta ctcaatccgc 5040 tcaactcttc ggatggaact catggggtgc gacctgaact cctgctccat gccgttgggg 5100 atggaatcaa aggctattag cgacgcccag atcaccgcga gctcctactt cactaacatg 5160 ttcgccacct ggagcccctc caaggccagg ctgcacttgc agggacggtc aaatgcctgg 5220 cggccgcaag tgaacaatcc gaaggaatgg cttcaagtgg atttccaaaa gaccatgaaa 5280 gtgaccggag tcaccaccca gggagtgaag tcccttctga cctcgatgta tgtgaaggag 5340 ttcctgatta gcagcagcca ggacgggcac cagtggaccc tgttcttcca aaacggaaag 5400 gtcaaggtgt tccaggggaa ccaggactcg ttcacacccg tggtgaactc cctggacccc 5460 ccactgctga cgcggtactt gaggattcat cctcagtcct gggtccatca gattgcattg 5520 cgaatggaag tcctgggctg cgaggcccag gacctgtact gaatcagcct gagctcgctg 5580 atcataatca acctctggat tacaaaattt gtgaaagatt gactggtatt cttaactatg 5640 ttgctccttt tacgctatgt ggatacgctg ctttaatgcc tttgtatcat gctattgctt 5700 cccgtatggc tttcattttc tcctccttgt ataaatcctg gttgctgtct ctttatgagg 5760 agttgtggcc cgttgtcagg caacgtggcg tggtgtgcac tgtgtttgct gacgcaaccc 5820 ccactggttg gggcattgcc accacctgtc agctcctttc cgggactttc gctttccccc 5880 tccctattgc cacggcggaa ctcatcgccg cctgccttgc ccgctgctgg acaggggctc 5940 ggctgttggg cactgacaat tccgtggtgt tgtcggggaa atcatcgtcc tttccttggc 6000 tgctcgcctg tgttgccacc tggattctgc gcgggacgtc cttctgctac gtcccttcgg 6060 ccctcaatcc agcggacctt ccttcccgcg gcctgctgcc ggctctgcgg cctcttccgc 6120 gtcttcgcct tcgccctcag acgagtcgga tctccctttg ggccgcctcc ccgctgatca 6180 gcctcgactg tgccttctag ttgccagcca tctgttgttt gcccctcccc cgtgccttcc 6240 ttgaccctgg aaggtgccac tcccactgtc ctttcctaat aaaatgagga aattgcatcg 6300 cattgtctga gtaggtgtca ttctattctg gggggtgggg tggggcagga cagcaagggg 6360 gaggattggg aagacaatag caggcatgct ggggatgcgg tgggctctat ggcttctgag 6420 gcggaaagaa cgggctcgag aagcttctag atatcctctc ttaaggtagc atcgagattt 6480 aaattaggga taacagggta atggcgcggg ccgcaaaatt taaaagaaga caccaaatca 6540 gatgccgccg gtcgccgccg gtaggcggga cttccggtac aagatggcgg acaattacgt 6600 catttcctgt gacgtcattt cctgtgacgt cacttccggt gggcgggact tccggaatta 6660 gggttggctc tgggccagcg cttggggttg acgtgccact aagatcaagc ggcgcgccgc 6720 ttgtcttagt gtcaaggcaa ccccaagcaa gctggcccag ag 6762 <210> 180 <211> 248 <212> ADN <213> Secuencia Artificial <220> <223> ITR 5' <400> 180 ctctgggcca gcttgcttgg ggttgccttg acactaagac aagcggcgcg ccgcttgatc 60 ttagtggcac gtcaacccca agcgctggcc cagagccaac cctaattccg gaagtcccgc 120 ccaccggaag tgacgtcaca ggaaatgacg tcacaggaaa tgacgtaatt gtccgccatc 180 ttgtaccgga agtcccgcct accggcggcg accggcggca tctgatttgg tgtcttcttt 240 taaatttt 248 <210> 181 <211> 248 <212> ADN <213> Secuencia Artificial <220> <223> ITR 3' <400> 181 aaaatttaaa agaagacacc aaatcagatg ccgccggtcg ccgccggtag gcgggacttc 60 cggtacaaga tggcggacaa ttacgtcatt tcctgtgacg tcatttcctg tgacgtcact 120 tccggtgggc gggacttccg gaattagggt tggctctggg ccagcgcttg gggttgacgt 180 gccactaaga tcaagcggcg cgccgcttgt cttagtgtca aggcaacccc aagcaagctg 240 gcccagag 248 <210> 182 <211> 6830 <212> ADN <213> Secuencia Artificial <220> <223> Secuencia de polinucléotidos sintética <400> 182 cggtgacgtg tttccggctg ttaggttgac cacgcgcatg ccgcgcggtc agcccaatag 60 ttaagccgga aacacgtcac cggaagtcac atgaccggaa gtcacgtgac cggaaacacg 120 tgacaggaag cacgtgaccg gaactacgtc accggatgtg cgtcaccgga agcatgtgac 180 cggaacttgc gtcacttccc cctcccctga ttggctggtt cgaacgaacg aaccctccaa 240 tgagactcaa ggacaagagg atattttgcg cgccaggaag tggcggcaat tcagtcgata 300 actataacgg tcctaaggta gcgatttaaa tacgcgctct cttaaggtag ccccgggacg 360 cgtcaattga gatctggatc cggtaccgaa ttcgcggccg cctcgacgac tagcgtttaa 420 ttaaacgcgt gtctgtctgc acatttcgta gagcgagtgt tccgatactc taatctccct 480 aggcaaggtt catatttgtg taggttactt attctccttt tgttgactaa gtcaataatc 540 agaatcagca ggtttggagt cagcttggca gggatcagca gcctgggttg gaaggagggg 600 gtataaaagc cccttcacca ggagaagccg tcacacagat ccacaagctc ctgaggtaag 660 tgccgtgtgt ggttcccgcg ggcctggcct ctttacgggt tatggccctt gcgtgccttg 720 aattactgac actgacatcc actttttctt tttctccaca gctagcgcca ccatgcagat 780 tgagctgtcc acttgtttct tcctgtgcct cctgcgcttc tgtttctccg ccactcgccg 840 gtactacctt ggagccgtgg agctttcatg ggactacatg cagagcgacc tgggcgaact 900 ccccgtggat gccagattcc ccccccgcgt gccaaagtcc ttccccttta acacctccgt 960 ggtgtacaag aaaaccctct ttgtcgagtt cactgaccac ctgttcaaca tcgccaagcc 1020 gcgcccacct tggatgggcc tcctgggacc gaccattcaa gctgaagtgt acgacaccgt 1080 ggtgatcacc ctgaagaaca tggcgtccca ccccgtgtcc ctgcatgcgg tcggagtgtc 1140 ctactggaag gcctccgaag gagctgagta cgacgaccag actagccagc gggaaaagga 1200 ggacgataaa gtgttcccgg gcggctcgca tacttacgtg tggcaagtcc tgaaggaaaa 1260 cggacctatg gcatccgatc ctctgtgcct gacttactcc tacctttccc atgtggacct 1320 cgtgaaggac ctgaacagcg ggctgattgg tgcacttctc gtgtgccgcg aaggttcgct 1380 cgctaaggaa aagacccaga ccctccataa gttcatcctt ttgttcgctg tgttcgatga 1440 aggaaagtca tggcattccg aaactaagaa ctcgctgatg caggaccggg atgccgcctc 1500 agcccgcgcc tggcctaaaa tgcatacagt caacggatac gtgaatcggt cactgcccgg 1560 gctcatcggt tgtcacagaa agtccgtgta ctggcacgtc atcggcatgg gcactacgcc 1620 tgaagtgcac tccatcttcc tggaagggca caccttcctc gtgcgcaacc accgccaggc 1680 ctctctggaa atctccccga ttacctttct gaccgcccag actctgctca tggacctggg 1740 gcagttcctt ctcttctgcc acatctccag ccatcagcac gacggaatgg aggcctacgt 1800 gaaggtggac tcatgcccgg aagaacctca gttgcggatg aagaacaacg aggaggccga 1860 ggactatgac gacgatttga ctgactccga gatggacgtc gtgcggttcg atgacgacaa 1920 cagccccagc ttcatccaga ttcgcagcgt ggccaagaag caccccaaaa cctgggtgca 1980 ctacatcgcg gccgaggaag aagattggga ctacgccccg ttggtgctgg cacccgatga 2040 ccggtcgtac aagtcccagt atctgaacaa tggtccgcag cggattggca gaaagtacaa 2100 gaaagtgcgg ttcatggcgt acactgacga aacgtttaag acccgggagg ccattcaaca 2160 tgagagcggc attctgggac cactgctgta cggagaggtc ggcgataccc tgctcatcat 2220 cttcaaaaac caggcctccc ggccttacaa catctaccct cacggaatca ccgacgtgcg 2280 gccactctac tcgcggcgcc tgccgaaggg cgtcaagcac ctgaaagact tccctatcct 2340 gccgggcgaa atcttcaagt ataagtggac cgtcaccgtg gaggacgggc ccaccaagag 2400 cgatcctagg tgtctgactc ggtactactc cagcttcgtg aacatggaac gggacctggc 2460 atcgggactc attggaccgc tgctgatctg ctacaaagag tcggtggatc aacgcggcaa 2520 ccagatcatg tccgacaagc gcaacgtgat cctgttctcc gtgtttgatg aaaacagatc 2580 ctggtacctc actgaaaaca tccagaggtt cctcccaaac cccgcaggag tgcaactgga 2640 ggaccctgag tttcaggcct cgaatatcat gcactcgatt aacggttacg tgttcgactc 2700 gctgcaactg agcgtgtgcc tccatgaagt cgcttactgg tacattctgt ccatcggcgc 2760 ccagactgac ttcctgagcg tgttcttttc cggttacacc tttaagcaca agatggtgta 2820 cgaagatacc ctgaccctgt tccctttctc cggcgaaacg gtgttcatgt cgatggagaa 2880 cccgggtctg tggattctgg gatgccacaa cagcgacttt cggaaccgcg gaatgactgc 2940 cctgctgaag gtgtcctcat gcgacaagaa caccggagac tactacgagg actcctacga 3000 ggatatctca gcctacctcc tgtccaagaa caacgcgatc gagccgcgca gcttcagcca 3060 gaacggcgcg ccaacatcag agagcgccac ccctgaaagt ggtcccggga gcgagccagc 3120 cacatctggg tcggaaacgc caggcacaag tgagtctgca actcccgagt ccggacctgg 3180 ctccgagcct gccactagcg gctccgagac tccgggaact tccgagagcg ctacaccaga 3240 aagcggaccc ggaaccagta ccgaacctag cgagggctct gctccgggca gcccagccgg 3300 ctctcctaca tccacggagg agggcacttc cgaatccgcc accccggagt cagggccagg 3360 atctgaaccc gctacctcag gcagtgagac gccaggaacg agcgagtccg ctacaccgga 3420 gagtgggcca gggagccctg ctggatctcc tacgtccact gaggaagggt caccagcggg 3480 ctcgcccacc agcactgaag aaggtgcctc gagcccgcct gtgctgaaga ggcaccagcg 3540 agaaattacc cggaccaccc tccaatcgga tcaggaggaa atcgactacg acgacaccat 3600 ctcggtggaa atgaagaagg aagatttcga tatctacgac gaggacgaaa atcagtcccc 3660 tcgctcattc caaaagaaaa ctagacacta ctttatcgcc gcggtggaaa gactgtggga 3720 ctatggaatg tcatccagcc ctcacgtcct tcggaaccgg gcccagagcg gatcggtgcc 3780 tcagttcaag aaagtggtgt tccaggagtt caccgacggc agcttcaccc agccgctgta 3840 ccggggagaa ctgaacgaac acctgggcct gctcggtccc tacatccgcg cggaagtgga 3900 ggataacatc atggtgacct tccgtaacca agcatccaga ccttactcct tctattcctc 3960 cctgatctca tacgaggagg accagcgcca aggcgccgag ccccgcaaga acttcgtcaa 4020 gcccaacgag actaagacct acttctggaa ggtccaacac catatggccc cgaccaagga 4080 tgagtttgac tgcaaggcct gggcctactt ctccgacgtg gaccttgaga aggatgtcca 4140 ttccggcctg atcgggccgc tgctcgtgtg tcacaccaac accctgaacc cagcgcatgg 4200 acgccaggtc accgtccagg agtttgctct gttcttcacc atttttgacg aaactaagtc 4260 ctggtacttc accgagaata tggagcgaaa ctgtagagcg ccctgcaata tccagatgga 4320 agatccgact ttcaaggaga actatagatt ccacgccatc aacgggtaca tcatggatac 4380 tctgccgggg ctggtcatgg cccaggatca gaggattcgg tggtacttgc tgtcaatggg 4440 atcgaacgaa aacattcact ccattcactt ctccggtcac gtgttcactg tgcgcaagaa 4500 ggaggagtac aagatggcgc tgtacaatct gtaccccggg gtgttcgaaa ctgtggagat 4560 gctgccgtcc aaggccggca tctggagagt ggagtgcctg atcggagagc acctccacgc 4620 ggggatgtcc accctcttcc tggtgtactc gaataagtgc cagaccccgc tgggcatggc 4680 ctcgggccac atcagagact tccagatcac agcaagcgga caatacggcc aatgggcgcc 4740 gaagctggcc cgcttgcact actccggatc gatcaacgca tggtccacca aggaaccgtt 4800 ctcgtggatt aaggtggacc tcctggcccc tatgattatc cacggaatta agacccaggg 4860 cgccaggcag aagttctcct ccctgtacat ctcgcaattc atcatcatgt acagcctgga 4920 cgggaagaag tggcagactt acaggggaaa ctccaccggc accctgatgg tctttttcgg 4980 caacgtggat tcctccggca ttaagcacaa catcttcaac ccaccgatca tagccagata 5040 tattaggctc caccccactc actactcaat ccgctcaact cttcggatgg aactcatggg 5100 gtgcgacctg aactcctgct ccatgccgtt ggggatggaa tcaaaggcta ttagcgacgc 5160 ccagatcacc gcgagctcct acttcactaa catgttcgcc acctggagcc cctccaaggc 5220 caggctgcac ttgcagggac ggtcaaatgc ctggcggccg caagtgaaca atccgaagga 5280 atggcttcaa gtggatttcc aaaagaccat gaaagtgacc ggagtcacca cccagggagt 5340 gaagtccctt ctgacctcga tgtatgtgaa ggagttcctg attagcagca gccaggacgg 5400 gcaccagtgg accctgttct tccaaaacgg aaaggtcaag gtgttccagg ggaaccagga 5460 ctcgttcaca cccgtggtga actccctgga ccccccactg ctgacgcggt acttgaggat 5520 tcatcctcag tcctgggtcc atcagattgc attgcgaatg gaagtcctgg gctgcgaggc 5580 ccaggacctg tactgaatca gcctgagctc gctgatcata atcaacctct ggattacaaa 5640 atttgtgaaa gattgactgg tattcttaac tatgttgctc cttttacgct atgtggatac 5700 gctgctttaa tgcctttgta tcatgctatt gcttcccgta tggctttcat tttctcctcc 5760 ttgtataaat cctggttgct gtctctttat gaggagttgt ggcccgttgt caggcaacgt 5820 ggcgtggtgt gcactgtgtt tgctgacgca acccccactg gttggggcat tgccaccacc 5880 tgtcagctcc tttccgggac tttcgctttc cccctcccta ttgccacggc ggaactcatc 5940 gccgcctgcc ttgcccgctg ctggacaggg gctcggctgt tgggcactga caattccgtg 6000 gtgttgtcgg ggaaatcatc gtcctttcct tggctgctcg cctgtgttgc cacctggatt 6060 ctgcgcggga cgtccttctg ctacgtccct tcggccctca atccagcgga ccttccttcc 6120 cgcggcctgc tgccggctct gcggcctctt ccgcgtcttc gccttcgccc tcagacgagt 6180 cggatctccc tttgggccgc ctccccgctg atcagcctcg actgtgcctt ctagttgcca 6240 gccatctgtt gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg ccactcccac 6300 tgtcctttcc taataaaatg aggaaattgc atcgcattgt ctgagtaggt gtcattctat 6360 tctggggggt ggggtggggc aggacagcaa gggggaggat tgggaagaca atagcaggca 6420 tgctggggat gcggtgggct ctatggcttc tgaggcggaa agaacgggct cgagaagctt 6480 ctagatatcc tctcttaagg tagcatcgag atttaaatta gggataacag ggtaatggcg 6540 cgggccgcca cttcctggcg cgcaaaatat cctcttgtcc ttgagtctca ttggagggtt 6600 cgttcgttcg aaccagccaa tcaggggagg gggaagtgac gcaagttccg gtcacatgct 6660 tccggtgacg cacatccggt gacgtagttc cggtcacgtg cttcctgtca cgtgtttccg 6720 gtcacgtgac ttccggtcat gtgacttccg gtgacgtgtt tccggcttaa ctattgggct 6780 gaccgcgcgg catgcgcgtg gtcaacctaa cagccggaaa cacgtcaccg 6830 <210> 183 <211> 282 <212> ADN <213> Secuencia Artificial <220> <223> ITR 5' <400> 183 cggtgacgtg tttccggctg ttaggttgac cacgcgcatg ccgcgcggtc agcccaatag 60 ttaagccgga aacacgtcac cggaagtcac atgaccggaa gtcacgtgac cggaaacacg 120 tgacaggaag cacgtgaccg gaactacgtc accggatgtg cgtcaccgga agcatgtgac 180 cggaacttgc gtcacttccc cctcccctga ttggctggtt cgaacgaacg aaccctccaa 240 tgagactcaa ggacaagagg atattttgcg cgccaggaag tg 282 <210> 184 <211> 282 <212> ADN <213> Secuencia Artificial <220> <223> ITR 3' <400> 184 cacttcctgg cgcgcaaaat atcctcttgt ccttgagtct cattggaggg ttcgttcgtt 60 cgaaccagcc aatcagggga gggggaagtg acgcaagttc cggtcacatg cttccggtga 120 cgcacatccg gtgacgtagt tccggtcacg tgcttcctgt cacgtgtttc cggtcacgtg 180 acttccggtc atgtgacttc cggtgacgtg tttccggctt aactattggg ctgaccgcgc 240 ggcatgcgcg tggtcaacct aacagccgga aacacgtcac cg 282 <210> 185 <211> 383 <212> ADN <213> Secuencia Artificial <220> <223> ITR 5' <400> 185 ccaaatcaga tgccgccggt cgccgccggt aggcgggact tccggtacaa gatggcggac 60 aattacgtca tttcctgtga cgtcatttcc tgtgacgtca cttccggtgg gcgggacttc 120 cggaattagg gttggctctg ggccagcttg cttggggttg ccttgacact aagacaagcg 180 gcgcgccgct tgatcttagt ggcacgtcaa ccccaagcgc tggcccagag ccaaccctaa 240 ttccggaagt cccgcccacc ggaagtgacg tcacaggaaa tgacgtcaca ggaaatgacg 300 taattgtccg ccatcttgta ccggaagtcc cgcctaccgg cggcgaccgg cggcatctga 360 tttggtgtct tcttttaaat ttt 383 <210> 186 <211> 383 <212> ADN <213> Secuencia Artificial <220> <223> ITR 3' <400> 186 aaaatttaaa agaagacacc aaatcagatg ccgccggtcg ccgccggtag gcgggacttc 60 cggtacaaga tggcggacaa ttacgtcatt tcctgtgacg tcatttcctg tgacgtcact 120 tccggtgggc gggacttccg gaattagggt tggctctggg ccagcgcttg gggttgacgt 180 gccactaaga tcaagcggcg cgccgcttgt cttagtgtca aggcaacccc aagcaagctg 240 gcccagagcc aaccctaatt ccggaagtcc cgcccaccgg aagtgacgtc acaggaaatg 300 acgtcacagg aaatgacgta attgtccgcc atcttgtacc ggaagtcccg cctaccggcg 360 gcgaccggcg gcatctgatt tgg 383 <210> 187 <211> 444 <212> ADN <213> Secuencia Artificial <220> <223> ITR 5' <400> 187 ctcattggag ggttcgttcg ttcgaaccag ccaatcaggg gagggggaag tgacgcaagt 60 tccggtcaca tgcttccggt gacgcacatc cggtgacgta gttccggtca cgtgcttcct 120 gtcacgtgtt tccggtcacg tgacttccgg tcatgtgact tccggtgacg tgtttccggc 180 tgttaggttg accacgcgca tgccgcgcgg tcagcccaat agttaagccg gaaacacgtc 240 accggaagtc acatgaccgg aagtcacgtg accggaaaca cgtgacagga agcacgtgac 300 cggaactacg tcaccggatg tgcgtcaccg gaagcatgtg accggaactt gcgtcacttc 360 cccctcccct gattggctgg ttcgaacgaa cgaaccctcc aatgagactc aaggacaaga 420 ggatattttg cgcgccagga agtg 444 <210> 188 <211> 444 <212> ADN <213> Secuencia Artificial <220> <223> ITR 3' <400> 188 cacttcctgg cgcgcaaaat atcctcttgt ccttgagtct cattggaggg ttcgttcgtt 60 cgaaccagcc aatcagggga gggggaagtg acgcaagttc cggtcacatg cttccggtga 120 cgcacatccg gtgacgtagt tccggtcacg tgcttcctgt cacgtgtttc cggtcacgtg 180 acttccggtc atgtgacttc cggtgacgtg tttccggctt aactattggg ctgaccgcgc 240 ggcatgcgcg tggtcaacct aacagccgga aacacgtcac cggaagtcac atgaccggaa 300 gtcacgtgac cggaaacacg tgacaggaag cacgtgaccg gaactacgtc accggatgtg 360 cgtcaccgga agcatgtgac cggaacttgc gtcacttccc cctcccctga ttggctggtt 420 cgaacgaacg aaccctccaa tgag 444 <210> 189 <211> 7032 <212> ADN <213> Secuencia Artificial <220> <223> Secuencia de polinucleotidos sintética <400> 189 ccaaatcaga tgccgccggt cgccgccggt aggcgggact tccggtacaa gatggcggac 60 aattacgtca tttcctgtga cgtcatttcc tgtgacgtca cttccggtgg gcgggacttc 120 cggaattagg gttggctctg ggccagcttg cttggggttg ccttgacact aagacaagcg 180 gcgcgccgct tgatcttagt ggcacgtcaa ccccaagcgc tggcccagag ccaaccctaa 240 ttccggaagt cccgcccacc ggaagtgacg tcacaggaaa tgacgtcaca ggaaatgacg 300 taattgtccg ccatcttgta ccggaagtcc cgcctaccgg cggcgaccgg cggcatctga 360 tttggtgtct tcttttaaat tttgcggcaa ttcagtcgat aactataacg gtcctaaggt 420 agcgatttaa atacgcgctc tcttaaggta gccccgggac gcgtcaattg agatctggat 480 ccggtaccga attcgcggcc gcctcgacga ctagcgttta attaaacgcg tgtctgtctg 540 cacatttcgt agagcgagtg ttccgatact ctaatctccc taggcaaggt tcatatttgt 600 gtaggttact tattctcctt ttgttgacta agtcaataat cagaatcagc aggtttggag 660 tcagcttggc agggatcagc agcctgggtt ggaaggaggg ggtataaaag ccccttcacc 720 aggagaagcc gtcacacaga tccacaagct cctgaggtaa gtgccgtgtg tggttcccgc 780 gggcctggcc tctttacggg ttatggccct tgcgtgcctt gaattactga cactgacatc 840 cactttttct ttttctccac agctagcgcc accatgcaga ttgagctgtc cacttgtttc 900 ttcctgtgcc tcctgcgctt ctgtttctcc gccactcgcc ggtactacct tggagccgtg 960 gagctttcat gggactacat gcagagcgac ctgggcgaac tccccgtgga tgccagattc 1020 cccccccgcg tgccaaagtc cttccccttt aacacctccg tggtgtacaa gaaaaccctc 1080 tttgtcgagt tcactgacca cctgttcaac atcgccaagc cgcgcccacc ttggatgggc 1140 ctcctgggac cgaccattca agctgaagtg tacgacaccg tggtgatcac cctgaagaac 1200 atggcgtccc accccgtgtc cctgcatgcg gtcggagtgt cctactggaa ggcctccgaa 1260 ggagctgagt acgacgacca gactagccag cgggaaaagg aggacgataa agtgttcccg 1320 ggcggctcgc atacttacgt gtggcaagtc ctgaaggaaa acggacctat ggcatccgat 1380 cctctgtgcc tgacttactc ctacctttcc catgtggacc tcgtgaagga cctgaacagc 1440 gggctgattg gtgcacttct cgtgtgccgc gaaggttcgc tcgctaagga aaagacccag 1500 accctccata agttcatcct tttgttcgct gtgttcgatg aaggaaagtc atggcattcc 1560 gaaactaaga actcgctgat gcaggaccgg gatgccgcct cagcccgcgc ctggcctaaa 1620 atgcatacag tcaacggata cgtgaatcgg tcactgcccg ggctcatcgg ttgtcacaga 1680 aagtccgtgt actggcacgt catcggcatg ggcactacgc ctgaagtgca ctccatcttc 1740 ctggaagggc acaccttcct cgtgcgcaac caccgccagg cctctctgga aatctccccg 1800 attacctttc tgaccgccca gactctgctc atggacctgg ggcagttcct tctcttctgc 1860 cacatctcca gccatcagca cgacggaatg gaggcctacg tgaaggtgga ctcatgcccg 1920 gaagaacctc agttgcggat gaagaacaac gaggaggccg aggactatga cgacgatttg 1980 actgactccg agatggacgt cgtgcggttc gatgacgaca acagccccag cttcatccag 2040 attcgcagcg tggccaagaa gcaccccaaa acctgggtgc actacatcgc ggccgaggaa 2100 gaagattggg actacgcccc gttggtgctg gcacccgatg accggtcgta caagtcccag 2160 tatctgaaca atggtccgca gcggattggc agaaagtaca agaaagtgcg gttcatggcg 2220 tacactgacg aaacgtttaa gacccgggag gccattcaac atgagagcgg cattctggga 2280 ccactgctgt acggagaggt cggcgatacc ctgctcatca tcttcaaaaa ccaggcctcc 2340 cggccttaca acatctaccc tcacggaatc accgacgtgc ggccactcta ctcgcggcgc 2400 ctgccgaagg gcgtcaagca cctgaaagac ttccctatcc tgccgggcga aatcttcaag 2460 tataagtgga ccgtcaccgt ggaggacggg cccaccaaga gcgatcctag gtgtctgact 2520 cggtactact ccagcttcgt gaacatggaa cgggacctgg catcgggact cattggaccg 2580 ctgctgatct gctacaaaga gtcggtggat caacgcggca accagatcat gtccgacaag 2640 cgcaacgtga tcctgttctc cgtgtttgat gaaaacagat cctggtacct cactgaaaac 2700 atccagaggt tcctcccaaa ccccgcagga gtgcaactgg aggaccctga gtttcaggcc 2760 tcgaatatca tgcactcgat taacggttac gtgttcgact cgctgcaact gagcgtgtgc 2820 ctccatgaag tcgcttactg gtacattctg tccatcggcg cccagactga cttcctgagc 2880 gtgttctttt ccggttacac ctttaagcac aagatggtgt acgaagatac cctgaccctg 2940 ttccctttct ccggcgaaac ggtgttcatg tcgatggaga acccgggtct gtggattctg 3000 ggatgccaca acagcgactt tcggaaccgc ggaatgactg ccctgctgaa ggtgtcctca 3060 tgcgacaaga acaccggaga ctactacgag gactcctacg aggatatctc agcctacctc 3120 ctgtccaaga acaacgcgat cgagccgcgc agcttcagcc agaacggcgc gccaacatca 3180 gagagcgcca cccctgaaag tggtcccggg agcgagccag ccacatctgg gtcggaaacg 3240 ccaggcacaa gtgagtctgc aactcccgag tccggacctg gctccgagcc tgccactagc 3300 ggctccgaga ctccgggaac ttccgagagc gctacaccag aaagcggacc cggaaccagt 3360 accgaaccta gcgagggctc tgctccgggc agcccagccg gctctcctac atccacggag 3420 gagggcactt ccgaatccgc caccccggag tcagggccag gatctgaacc cgctacctca 3480 ggcagtgaga cgccaggaac gagcgagtcc gctacaccgg agagtgggcc agggagccct 3540 gctggatctc ctacgtccac tgaggaaggg tcaccagcgg gctcgcccac cagcactgaa 3600 gaaggtgcct cgagcccgcc tgtgctgaag aggcaccagc gagaaattac ccggaccacc 3660 ctccaatcgg atcaggagga aatcgactac gacgacacca tctcggtgga aatgaagaag 3720 gaagatttcg atatctacga cgaggacgaa aatcagtccc ctcgctcatt ccaaaagaaa 3780 actagacact actttatcgc cgcggtggaa agactgtggg actatggaat gtcatccagc 3840 cctcacgtcc ttcggaaccg ggcccagagc ggatcggtgc ctcagttcaa gaaagtggtg 3900 ttccaggagt tcaccgacgg cagcttcacc cagccgctgt accggggaga actgaacgaa 3960 cacctgggcc tgctcggtcc ctacatccgc gcggaagtgg aggataacat catggtgacc 4020 ttccgtaacc aagcatccag accttactcc ttctattcct ccctgatctc atacgaggag 4080 gaccagcgcc aaggcgccga gccccgcaag aacttcgtca agcccaacga gactaagacc 4140 tacttctgga aggtccaaca ccatatggcc ccgaccaagg atgagtttga ctgcaaggcc 4200 tgggcctact tctccgacgt ggaccttgag aaggatgtcc attccggcct gatcgggccg 4260 ctgctcgtgt gtcacaccaa caccctgaac ccagcgcatg gacgccaggt caccgtccag 4320 gagtttgctc tgttcttcac catttttgac gaaactaagt cctggtactt caccgagaat 4380 atggagcgaa actgtagagc gccctgcaat atccagatgg aagatccgac tttcaaggag 4440 aactatagat tccacgccat caacgggtac atcatggata ctctgccggg gctggtcatg 4500 gcccaggatc agaggattcg gtggtacttg ctgtcaatgg gatcgaacga aaacattcac 4560 tccattcact tctccggtca cgtgttcact gtgcgcaaga aggaggagta caagatggcg 4620 ctgtacaatc tgtaccccgg ggtgttcgaa actgtggaga tgctgccgtc caaggccggc 4680 atctggagag tggagtgcct gatcggagag cacctccacg cggggatgtc caccctcttc 4740 ctggtgtact cgaataagtg ccagaccccg ctgggcatgg cctcgggcca catcagagac 4800 ttccagatca cagcaagcgg acaatacggc caatgggcgc cgaagctggc ccgcttgcac 4860 tactccggat cgatcaacgc atggtccacc aaggaaccgt tctcgtggat taaggtggac 4920 ctcctggccc ctatgattat ccacggaatt aagacccagg gcgccaggca gaagttctcc 4980 tccctgtaca tctcgcaatt catcatcatg tacagcctgg acgggaagaa gtggcagact 5040 tacaggggaa actccaccgg caccctgatg gtctttttcg gcaacgtgga ttcctccggc 5100 attaagcaca acatcttcaa cccaccgatc atagccagat atattaggct ccaccccact 5160 cactactcaa tccgctcaac tcttcggatg gaactcatgg ggtgcgacct gaactcctgc 5220 tccatgccgt tggggatgga atcaaaggct attagcgacg cccagatcac cgcgagctcc 5280 tacttcacta acatgttcgc cacctggagc ccctccaagg ccaggctgca cttgcaggga 5340 cggtcaaatg cctggcggcc gcaagtgaac aatccgaagg aatggcttca agtggatttc 5400 caaaagacca tgaaagtgac cggagtcacc acccagggag tgaagtccct tctgacctcg 5460 atgtatgtga aggagttcct gattagcagc agccaggacg ggcaccagtg gaccctgttc 5520 ttccaaaacg gaaaggtcaa ggtgttccag gggaaccagg actcgttcac acccgtggtg 5580 aactccctgg accccccact gctgacgcgg tacttgagga ttcatcctca gtcctgggtc 5640 catcagattg cattgcgaat ggaagtcctg ggctgcgagg cccaggacct gtactgaatc 5700 agcctgagct cgctgatcat aatcaacctc tggattacaa aatttgtgaa agattgactg 5760 gtattcttaa ctatgttgct ccttttacgc tatgtggata cgctgcttta atgcctttgt 5820 atcatgctat tgcttcccgt atggctttca ttttctcctc cttgtataaa tcctggttgc 5880 tgtctcttta tgaggagttg tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt 5940 ttgctgacgc aacccccact ggttggggca ttgccaccac ctgtcagctc ctttccggga 6000 ctttcgcttt ccccctccct attgccacgg cggaactcat cgccgcctgc cttgcccgct 6060 gctggacagg ggctcggctg ttgggcactg acaattccgt ggtgttgtcg gggaaatcat 6120 cgtcctttcc ttggctgctc gcctgtgttg ccacctggat tctgcgcggg acgtccttct 6180 gctacgtccc ttcggccctc aatccagcgg accttccttc ccgcggcctg ctgccggctc 6240 tgcggcctct tccgcgtctt cgccttcgcc ctcagacgag tcggatctcc ctttgggccg 6300 cctccccgct gatcagcctc gactgtgcct tctagttgcc agccatctgt tgtttgcccc 6360 tcccccgtgc cttccttgac cctggaaggt gccactccca ctgtcctttc ctaataaaat 6420 gaggaaattg catcgcattg tctgagtagg tgtcattcta ttctgggggg tggggtgggg 6480 caggacagca agggggagga ttgggaagac aatagcaggc atgctgggga tgcggtgggc 6540 tctatggctt ctgaggcgga aagaacgggc tcgagaagct tctagatatc ctctcttaag 6600 gtagcatcga gatttaaatt agggataaca gggtaatggc gcgggccgca aaatttaaaa 6660 gaagacacca aatcagatgc cgccggtcgc cgccggtagg cgggacttcc ggtacaagat 6720 ggcggacaat tacgtcattt cctgtgacgt catttcctgt gacgtcactt ccggtgggcg 6780 ggacttccgg aattagggtt ggctctgggc cagcgcttgg ggttgacgtg ccactaagat 6840 caagcggcgc gccgcttgtc ttagtgtcaa ggcaacccca agcaagctgg cccagagcca 6900 accctaattc cggaagtccc gcccaccgga agtgacgtca caggaaatga cgtcacagga 6960 aatgacgtaa ttgtccgcca tcttgtaccg gaagtcccgc ctaccggcgg cgaccggcgg 7020 catctgattt gg 7032 <210> 190 <211> 6824 <212> ADN <213> Secuencia Artificial <220> <223> Secuencia de polinucleótidos sintética <400> 190 ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt 60 ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact 120 aggggttcct gcggcaattc agtcgataac tataacggtc ctaaggtagc gatttaaata 180 cgcgctctct taaggtagcc ccgggacgcg tcaattgaga tctggatccg gtaccgaatt 240 cgcggccgcc tcgacgacta gcgtttaatt aaatcgaggt gagccccacg ttctgcttca 300 ctctccccat ctcccccccc tccccacccc caattttgta tttatttatt ttttaattat 360 tttgtgcagc gatgggggcg gggggggggg gggggcgcgc gccaggcggg gcggggcggg 420 gcgaggggcg gggcggggcg aggcggagag gtgcggcggc agccaatcag agcggcgcgc 480 tccgaaagtt tccttttatg gcgaggcggc ggcggcggcg gccctataaa aagcgaagcg 540 cgcggcgggc gggagtcgct gcgcgctgcc ttcgccccgt gccccgctcc gccgccgcct 600 cgcgccgccc gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg 660 gcccttctcc ttcgggctgt aattagcgct tggtttaatg acggcttgtt tcttttctgt 720 ggctgcgtga aagccttgag gggctccggg agggcccttt gtgcgggggg agcggctcgg 780 ggctgtccgc ggggggacgg ctgccttcgg gggggacggg gcagggcggg gttcggcttc 840 tggcgtgtga ccggcggctc tagagcctct gctaaccatg ttcatgcctt cttctttttc 900 ctacaggcta gcgccaccat gcagattgag ctgtccactt gtttcttcct gtgcctcctg 960 cgcttctgtt tctccgccac tcgccggtac taccttggag ccgtggagct ttcatgggac 1020 tacatgcaga gcgacctggg cgaactcccc gtggatgcca gattcccccc ccgcgtgcca 1080 aagtccttcc cctttaacac ctccgtggtg tacaagaaaa ccctctttgt cgagttcact 1140 gaccacctgt tcaacatcgc caagccgcgc ccaccttgga tgggcctcct gggaccgacc 1200 attcaagctg aagtgtacga caccgtggtg atcaccctga agaacatggc gtcccacccc 1260 gtgtccctgc atgcggtcgg agtgtcctac tggaaggcct ccgaaggagc tgagtacgac 1320 gaccagacta gccagcggga aaaggaggac gataaagtgt tcccgggcgg ctcgcatact 1380 tacgtgtggc aagtcctgaa ggaaaacgga cctatggcat ccgatcctct gtgcctgact 1440 tactcctacc tttcccatgt ggacctcgtg aaggacctga acagcgggct gattggtgca 1500 cttctcgtgt gccgcgaagg ttcgctcgct aaggaaaaga cccagaccct ccataagttc 1560 atccttttgt tcgctgtgtt cgatgaagga aagtcatggc attccgaaac taagaactcg 1620 ctgatgcagg accgggatgc cgcctcagcc cgcgcctggc ctaaaatgca tacagtcaac 1680 ggatacgtga atcggtcact gcccgggctc atcggttgtc acagaaagtc cgtgtactgg 1740 cacgtcatcg gcatgggcac tacgcctgaa gtgcactcca tcttcctgga agggcacacc 1800 ttcctcgtgc gcaaccaccg ccaggcctct ctggaaatct ccccgattac ctttctgacc 1860 gcccagactc tgctcatgga cctggggcag ttccttctct tctgccacat ctccagccat 1920 cagcacgacg gaatggaggc ctacgtgaag gtggactcat gcccggaaga acctcagttg 1980 cggatgaaga acaacgagga ggccgaggac tatgacgacg atttgactga ctccgagatg 2040 gacgtcgtgc ggttcgatga cgacaacagc cccagcttca tccagattcg cagcgtggcc 2100 aagaagcacc ccaaaacctg ggtgcactac atcgcggccg aggaagaaga ttgggactac 2160 gccccgttgg tgctggcacc cgatgaccgg tcgtacaagt cccagtatct gaacaatggt 2220 ccgcagcgga ttggcagaaa gtacaagaaa gtgcggttca tggcgtacac tgacgaaacg 2280 tttaagaccc gggaggccat tcaacatgag agcggcattc tgggaccact gctgtacgga 2340 gaggtcggcg ataccctgct catcatcttc aaaaaccagg cctcccggcc ttacaacatc 2400 taccctcacg gaatcaccga cgtgcggcca ctctactcgc ggcgcctgcc gaagggcgtc 2460 aagcacctga aagacttccc tatcctgccg ggcgaaatct tcaagtataa gtggaccgtc 2520 accgtggagg acgggcccac caagagcgat cctaggtgtc tgactcggta ctactccagc 2580 ttcgtgaaca tggaacggga cctggcatcg ggactcattg gaccgctgct gatctgctac 2640 aaagagtcgg tggatcaacg cggcaaccag atcatgtccg acaagcgcaa cgtgatcctg 2700 ttctccgtgt ttgatgaaaa cagatcctgg tacctcactg aaaacatcca gaggttcctc 2760 ccaaaccccg caggagtgca actggaggac cctgagtttc aggcctcgaa tatcatgcac 2820 tcgattaacg gttacgtgtt cgactcgctg caactgagcg tgtgcctcca tgaagtcgct 2880 tactggtaca ttctgtccat cggcgcccag actgacttcc tgagcgtgtt cttttccggt 2940 tacaccttta agcacaagat ggtgtacgaa gataccctga ccctgttccc tttctccggc 3000 gaaacggtgt tcatgtcgat ggagaacccg ggtctgtgga ttctgggatg ccacaacagc 3060 gactttcgga accgcggaat gactgccctg ctgaaggtgt cctcatgcga caagaacacc 3120 ggagactact acgaggactc ctacgaggat atctcagcct acctcctgtc caagaacaac 3180 gcgatcgagc cgcgcagctt cagccagaac ggcgcgccaa catcagagag cgccacccct 3240 gaaagtggtc ccgggagcga gccagccaca tctgggtcgg aaacgccagg cacaagtgag 3300 tctgcaactc ccgagtccgg acctggctcc gagcctgcca ctagcggctc cgagactccg 3360 ggaacttccg agagcgctac accagaaagc ggacccggaa ccagtaccga acctagcgag 3420 ggctctgctc cgggcagccc agccggctct cctacatcca cggaggaggg cacttccgaa 3480 tccgccaccc cggagtcagg gccaggatct gaacccgcta cctcaggcag tgagacgcca 3540 ggaacgagcg agtccgctac accggagagt gggccaggga gccctgctgg atctcctacg 3600 tccactgagg aagggtcacc agcgggctcg cccaccagca ctgaagaagg tgcctcgagc 3660 ccgcctgtgc tgaagaggca ccagcgagaa attacccgga ccaccctcca atcggatcag 3720 gaggaaatcg actacgacga caccatctcg gtggaaatga agaaggaaga tttcgatatc 3780 tacgacgagg acgaaaatca gtcccctcgc tcattccaaa agaaaactag acactacttt 3840 atcgccgcgg tggaaagact gtgggactat ggaatgtcat ccagccctca cgtccttcgg 3900 aaccgggccc agagcggatc ggtgcctcag ttcaagaaag tggtgttcca ggagttcacc 3960 gacggcagct tcacccagcc gctgtaccgg ggagaactga acgaacacct gggcctgctc 4020 ggtccctaca tccgcgcgga agtggaggat aacatcatgg tgaccttccg taaccaagca 4080 tccagacctt actccttcta ttcctccctg atctcatacg aggaggacca gcgccaaggc 4140 gccgagcccc gcaagaactt cgtcaagccc aacgagacta agacctactt ctggaaggtc 4200 caacaccata tggccccgac caaggatgag tttgactgca aggcctgggc ctacttctcc 4260 gacgtggacc ttgagaagga tgtccattcc ggcctgatcg ggccgctgct cgtgtgtcac 4320 accaacaccc tgaacccagc gcatggacgc caggtcaccg tccaggagtt tgctctgttc 4380 ttcaccattt ttgacgaaac taagtcctgg tacttcaccg agaatatgga gcgaaactgt 4440 agagcgccct gcaatatcca gatggaagat ccgactttca aggagaacta tagattccac 4500 gccatcaacg ggtacatcat ggatactctg ccggggctgg tcatggccca ggatcagagg 4560 attcggtggt acttgctgtc aatgggatcg aacgaaaaca ttcactccat tcacttctcc 4620 ggtcacgtgt tcactgtgcg caagaaggag gagtacaaga tggcgctgta caatctgtac 4680 cccggggtgt tcgaaactgt ggagatgctg ccgtccaagg ccggcatctg gagagtggag 4740 tgcctgatcg gagagcacct ccacgcgggg atgtccaccc tcttcctggt gtactcgaat 4800 aagtgccaga ccccgctggg catggcctcg ggccacatca gagacttcca gatcacagca 4860 agcggacaat acggccaatg ggcgccgaag ctggcccgct tgcactactc cggatcgatc 4920 aacgcatggt ccaccaagga accgttctcg tggattaagg tggacctcct ggcccctatg 4980 attatccacg gaattaagac ccagggcgcc aggcagaagt tctcctccct gtacatctcg 5040 caattcatca tcatgtacag cctggacggg aagaagtggc agacttacag gggaaactcc 5100 accggcaccc tgatggtctt tttcggcaac gtggattcct ccggcattaa gcacaacatc 5160 ttcaacccac cgatcatagc cagatatatt aggctccacc ccactcacta ctcaatccgc 5220 tcaactcttc ggatggaact catggggtgc gacctgaact cctgctccat gccgttgggg 5280 atggaatcaa aggctattag cgacgcccag atcaccgcga gctcctactt cactaacatg 5340 ttcgccacct ggagcccctc caaggccagg ctgcacttgc agggacggtc aaatgcctgg 5400 cggccgcaag tgaacaatcc gaaggaatgg cttcaagtgg atttccaaaa gaccatgaaa 5460 gtgaccggag tcaccaccca gggagtgaag tcccttctga cctcgatgta tgtgaaggag 5520 ttcctgatta gcagcagcca ggacgggcac cagtggaccc tgttcttcca aaacggaaag 5580 gtcaaggtgt tccaggggaa ccaggactcg ttcacacccg tggtgaactc cctggacccc 5640 ccactgctga cgcggtactt gaggattcat cctcagtcct gggtccatca gattgcattg 5700 cgaatggaag tcctgggctg cgaggcccag gacctgtact gaatcagcct gagctcgctg 5760 atcataatca acctctggat tacaaaattt gtgaaagatt gactggtatt cttaactatg 5820 ttgctccttt tacgctatgt ggatacgctg ctttaatgcc tttgtatcat gctattgctt 5880 cccgtatggc tttcattttc tcctccttgt ataaatcctg gttgctgtct ctttatgagg 5940 agttgtggcc cgttgtcagg caacgtggcg tggtgtgcac tgtgtttgct gacgcaaccc 6000 ccactggttg gggcattgcc accacctgtc agctcctttc cgggactttc gctttccccc 6060 tccctattgc cacggcggaa ctcatcgccg cctgccttgc ccgctgctgg acaggggctc 6120 ggctgttggg cactgacaat tccgtggtgt tgtcggggaa atcatcgtcc tttccttggc 6180 tgctcgcctg tgttgccacc tggattctgc gcgggacgtc cttctgctac gtcccttcgg 6240 ccctcaatcc agcggacctt ccttcccgcg gcctgctgcc ggctctgcgg cctcttccgc 6300 gtcttcgcct tcgccctcag acgagtcgga tctccctttg ggccgcctcc ccgctgatca 6360 gcctcgactg tgccttctag ttgccagcca tctgttgttt gcccctcccc cgtgccttcc 6420 ttgaccctgg aaggtgccac tcccactgtc ctttcctaat aaaatgagga aattgcatcg 6480 cattgtctga gtaggtgtca ttctattctg gggggtgggg tggggcagga cagcaagggg 6540 gaggattggg aagacaatag caggcatgct ggggatgcgg tgggctctat ggcttctgag 6600 gcggaaagaa cgggctcgag aagcttctag atatcctctc ttaaggtagc atcgagattt 6660 aaattaggga taacagggta atggcgcggg ccgcaggaac ccctagtgat ggagttggcc 6720 actccctctc tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc 6780 ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc gcag 6824 <210> 191 <211> 278 <212> ADN <213> Secuencia Artificial <220> <223> Secuencia de polinucleótidos sintética <400> 191 tcgaggtgag ccccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa 60 ttttgtattt atttattttt taattatttt gtgcagcgat gggggcgggg gggggggggg 120 ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg cggggcgagg cggagaggtg 180 cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc ttttatggcg aggcggcggc 240 ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcg 278 <210> 192 <211> 262 <212> ADN <213> Secuencia Artificial <220> <223> Secuencia de polinucleótidos sintética <400> 192 gtgagcgggc gggacggccc ttctccttcg ggctgtaatt agcgcttggt ttaatgacgg 60 cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc tccgggaggg ccctttgtgc 120 ggggggagcg gctcggggct gtccgcgggg ggacggctgc cttcgggggg gacggggcag 180 ggcggggttc ggcttctggc gtgtgaccgg cggctctaga gcctctgcta accatgttca 240 tgccttcttc tttttcctac ag 262 <210> 193 <211> 130 <212> ADN <213> Secuencia Artificial <220> <223> ITR 3' <400> 193 aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg 60 ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc 120 gagcgcgcag 130 <210> 194 <211> 7154 <212> ADN <213> Secuencia Artificial <220> <223> Secuencia de polinucléotidos sintética <400> 194 ctcattggag ggttcgttcg ttcgaaccag ccaatcaggg gagggggaag tgacgcaagt 60 tccggtcaca tgcttccggt gacgcacatc cggtgacgta gttccggtca cgtgcttcct 120 gtcacgtgtt tccggtcacg tgacttccgg tcatgtgact tccggtgacg tgtttccggc 180 tgttaggttg accacgcgca tgccgcgcgg tcagcccaat agttaagccg gaaacacgtc 240 accggaagtc acatgaccgg aagtcacgtg accggaaaca cgtgacagga agcacgtgac 300 cggaactacg tcaccggatg tgcgtcaccg gaagcatgtg accggaactt gcgtcacttc 360 cccctcccct gattggctgg ttcgaacgaa cgaaccctcc aatgagactc aaggacaaga 420 ggatattttg cgcgccagga agtggcggca attcagtcga taactataac ggtcctaagg 480 tagcgattta aatacgcgct ctcttaaggt agccccggga cgcgtcaatt gagatctgga 540 tccggtaccg aattcgcggc cgcctcgacg actagcgttt aattaaacgc gtgtctgtct 600 gcacatttcg tagagcgagt gttccgatac tctaatctcc ctaggcaagg ttcatatttg 660 tgtaggttac ttattctcct tttgttgact aagtcaataa tcagaatcag caggtttgga 720 gtcagcttgg cagggatcag cagcctgggt tggaaggagg gggtataaaa gccccttcac 780 caggagaagc cgtcacacag atccacaagc tcctgaggta agtgccgtgt gtggttcccg 840 cgggcctggc ctctttacgg gttatggccc ttgcgtgcct tgaattactg acactgacat 900 ccactttttc tttttctcca cagctagcgc caccatgcag attgagctgt ccacttgttt 960 cttcctgtgc ctcctgcgct tctgtttctc cgccactcgc cggtactacc ttggagccgt 1020 ggagctttca tgggactaca tgcagagcga cctgggcgaa ctccccgtgg atgccagatt 1080 ccccccccgc gtgccaaagt ccttcccctt taacacctcc gtggtgtaca agaaaaccct 1140 ctttgtcgag ttcactgacc acctgttcaa catcgccaag ccgcgcccac cttggatggg 1200 cctcctggga ccgaccattc aagctgaagt gtacgacacc gtggtgatca ccctgaagaa 1260 catggcgtcc caccccgtgt ccctgcatgc ggtcggagtg tcctactgga aggcctccga 1320 aggagctgag tacgacgacc agactagcca gcgggaaaag gaggacgata aagtgttccc 1380 gggcggctcg catacttacg tgtggcaagt cctgaaggaa aacggaccta tggcatccga 1440 tcctctgtgc ctgacttact cctacctttc ccatgtggac ctcgtgaagg acctgaacag 1500 cgggctgatt ggtgcacttc tcgtgtgccg cgaaggttcg ctcgctaagg aaaagaccca 1560 gaccctccat aagttcatcc ttttgttcgc tgtgttcgat gaaggaaagt catggcattc 1620 cgaaactaag aactcgctga tgcaggaccg ggatgccgcc tcagcccgcg cctggcctaa 1680 aatgcataca gtcaacggat acgtgaatcg gtcactgccc gggctcatcg gttgtcacag 1740 aaagtccgtg tactggcacg tcatcggcat gggcactacg cctgaagtgc actccatctt 1800 cctggaaggg cacaccttcc tcgtgcgcaa ccaccgccag gcctctctgg aaatctcccc 1860 gattaccttt ctgaccgccc agactctgct catggacctg gggcagttcc ttctcttctg 1920 ccacatctcc agccatcagc acgacggaat ggaggcctac gtgaaggtgg actcatgccc 1980 ggaagaacct cagttgcgga tgaagaacaa cgaggaggcc gaggactatg acgacgattt 2040 gactgactcc gagatggacg tcgtgcggtt cgatgacgac aacagcccca gcttcatcca 2100 gattcgcagc gtggccaaga agcaccccaa aacctgggtg cactacatcg cggccgagga 2160 agaagattgg gactacgccc cgttggtgct ggcacccgat gaccggtcgt acaagtccca 2220 gtatctgaac aatggtccgc agcggattgg cagaaagtac aagaaagtgc ggttcatggc 2280 gtacactgac gaaacgttta agacccggga ggccattcaa catgagagcg gcattctggg 2340 accactgctg tacggagagg tcggcgatac cctgctcatc atcttcaaaa accaggcctc 2400 ccggccttac aacatctacc ctcacggaat caccgacgtg cggccactct actcgcggcg 2460 cctgccgaag ggcgtcaagc acctgaaaga cttccctatc ctgccgggcg aaatcttcaa 2520 gtataagtgg accgtcaccg tggaggacgg gcccaccaag agcgatccta ggtgtctgac 2580 tcggtactac tccagcttcg tgaacatgga acgggacctg gcatcgggac tcattggacc 2640 gctgctgatc tgctacaaag agtcggtgga tcaacgcggc aaccagatca tgtccgacaa 2700 gcgcaacgtg atcctgttct ccgtgtttga tgaaaacaga tcctggtacc tcactgaaaa 2760 catccagagg ttcctcccaa accccgcagg agtgcaactg gaggaccctg agtttcaggc 2820 ctcgaatatc atgcactcga ttaacggtta cgtgttcgac tcgctgcaac tgagcgtgtg 2880 cctccatgaa gtcgcttact ggtacattct gtccatcggc gcccagactg acttcctgag 2940 cgtgttcttt tccggttaca cctttaagca caagatggtg tacgaagata ccctgaccct 3000 gttccctttc tccggcgaaa cggtgttcat gtcgatggag aacccgggtc tgtggattct 3060 gggatgccac aacagcgact ttcggaaccg cggaatgact gccctgctga aggtgtcctc 3120 atgcgacaag aacaccggag actactacga ggactcctac gaggatatct cagcctacct 3180 cctgtccaag aacaacgcga tcgagccgcg cagcttcagc cagaacggcg cgccaacatc 3240 agagagcgcc acccctgaaa gtggtcccgg gagcgagcca gccacatctg ggtcggaaac 3300 gccaggcaca agtgagtctg caactcccga gtccggacct ggctccgagc ctgccactag 3360 cggctccgag actccgggaa cttccgagag cgctacacca gaaagcggac ccggaaccag 3420 taccgaacct agcgagggct ctgctccggg cagcccagcc ggctctccta catccacgga 3480 ggagggcact tccgaatccg ccaccccgga gtcagggcca ggatctgaac ccgctacctc 3540 aggcagtgag acgccaggaa cgagcgagtc cgctacaccg gagagtgggc cagggagccc 3600 tgctggatct cctacgtcca ctgaggaagg gtcaccagcg ggctcgccca ccagcactga 3660 agaaggtgcc tcgagcccgc ctgtgctgaa gaggcaccag cgagaaatta cccggaccac 3720 cctccaatcg gatcaggagg aaatcgacta cgacgacacc atctcggtgg aaatgaagaa 3780 ggaagatttc gatatctacg acgaggacga aaatcagtcc cctcgctcat tccaaaagaa 3840 aactagacac tactttatcg ccgcggtgga aagactgtgg gactatggaa tgtcatccag 3900 ccctcacgtc cttcggaacc gggcccagag cggatcggtg cctcagttca agaaagtggt 3960 gttccaggag ttcaccgacg gcagcttcac ccagccgctg taccggggag aactgaacga 4020 acacctgggc ctgctcggtc cctacatccg cgcggaagtg gaggataaca tcatggtgac 4080 cttccgtaac caagcatcca gaccttactc cttctattcc tccctgatct catacgagga 4140 ggaccagcgc caaggcgccg agccccgcaa gaacttcgtc aagcccaacg agactaagac 4200 ctacttctgg aaggtccaac accatatggc cccgaccaag gatgagtttg actgcaaggc 4260 ctgggcctac ttctccgacg tggaccttga gaaggatgtc cattccggcc tgatcgggcc 4320 gctgctcgtg tgtcacacca acaccctgaa cccagcgcat ggacgccagg tcaccgtcca 4380 ggagtttgct ctgttcttca ccatttttga cgaaactaag tcctggtact tcaccgagaa 4440 tatggagcga aactgtagag cgccctgcaa tatccagatg gaagatccga ctttcaagga 4500 gaactataga ttccacgcca tcaacgggta catcatggat actctgccgg ggctggtcat 4560 ggcccaggat cagaggattc ggtggtactt gctgtcaatg ggatcgaacg aaaacattca 4620 ctccattcac ttctccggtc acgtgttcac tgtgcgcaag aaggaggagt acaagatggc 4680 gctgtacaat ctgtaccccg gggtgttcga aactgtggag atgctgccgt ccaaggccgg 4740 catctggaga gtggagtgcc tgatcggaga gcacctccac gcggggatgt ccaccctctt 4800 cctggtgtac tcgaataagt gccagacccc gctgggcatg gcctcgggcc acatcagaga 4860 cttccagatc acagcaagcg gacaatacgg ccaatgggcg ccgaagctgg cccgcttgca 4920 ctactccgga tcgatcaacg catggtccac caaggaaccg ttctcgtgga ttaaggtgga 4980 cctcctggcc cctatgatta tccacggaat taagacccag ggcgccaggc agaagttctc 5040 ctccctgtac atctcgcaat tcatcatcat gtacagcctg gacgggaaga agtggcagac 5100 ttacagggga aactccaccg gcaccctgat ggtctttttc ggcaacgtgg attcctccgg 5160 cattaagcac aacatcttca acccaccgat catagccaga tatattaggc tccaccccac 5220 tcactactca atccgctcaa ctcttcggat ggaactcatg gggtgcgacc tgaactcctg 5280 ctccatgccg ttggggatgg aatcaaaggc tattagcgac gcccagatca ccgcgagctc 5340 ctacttcact aacatgttcg ccacctggag cccctccaag gccaggctgc acttgcaggg 5400 acggtcaaat gcctggcggc cgcaagtgaa caatccgaag gaatggcttc aagtggattt 5460 ccaaaagacc atgaaagtga ccggagtcac cacccaggga gtgaagtccc ttctgacctc 5520 gatgtatgtg aaggagttcc tgattagcag cagccaggac gggcaccagt ggaccctgtt 5580 cttccaaaac ggaaaggtca aggtgttcca ggggaaccag gactcgttca cacccgtggt 5640 gaactccctg gaccccccac tgctgacgcg gtacttgagg attcatcctc agtcctgggt 5700 ccatcagatt gcattgcgaa tggaagtcct gggctgcgag gcccaggacc tgtactgaat 5760 cagcctgagc tcgctgatca taatcaacct ctggattaca aaatttgtga aagattgact 5820 ggtattctta actatgttgc tccttttacg ctatgtggat acgctgcttt aatgcctttg 5880 tatcatgcta ttgcttcccg tatggctttc attttctcct ccttgtataa atcctggttg 5940 ctgtctcttt atgaggagtt gtggcccgtt gtcaggcaac gtggcgtggt gtgcactgtg 6000 tttgctgacg caacccccac tggttggggc attgccacca cctgtcagct cctttccggg 6060 actttcgctt tccccctccc tattgccacg gcggaactca tcgccgcctg ccttgcccgc 6120 tgctggacag gggctcggct gttgggcact gacaattccg tggtgttgtc ggggaaatca 6180 tcgtcctttc cttggctgct cgcctgtgtt gccacctgga ttctgcgcgg gacgtccttc 6240 tgctacgtcc cttcggccct caatccagcg gaccttcctt cccgcggcct gctgccggct 6300 ctgcggcctc ttccgcgtct tcgccttcgc cctcagacga gtcggatctc cctttgggcc 6360 gcctccccgc tgatcagcct cgactgtgcc ttctagttgc cagccatctg ttgtttgccc 6420 ctcccccgtg ccttccttga ccctggaagg tgccactccc actgtccttt cctaataaaa 6480 tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct attctggggg gtggggtggg 6540 gcaggacagc aagggggagg attgggaaga caatagcagg catgctgggg atgcggtggg 6600 ctctatggct tctgaggcgg aaagaacggg ctcgagaagc ttctagatat cctctcttaa 6660 ggtagcatcg agatttaaat tagggataac agggtaatgg cgcgggccgc cacttcctgg 6720 cgcgcaaaat atcctcttgt ccttgagtct cattggaggg ttcgttcgtt cgaaccagcc 6780 aatcagggga gggggaagtg acgcaagttc cggtcacatg cttccggtga cgcacatccg 6840 gtgacgtagt tccggtcacg tgcttcctgt cacgtgtttc cggtcacgtg acttccggtc 6900 atgtgacttc cggtgacgtg tttccggctt aactattggg ctgaccgcgc ggcatgcgcg 6960 tggtcaacct aacagccgga aacacgtcac cggaagtcac atgaccggaa gtcacgtgac 7020 cggaaacacg tgacaggaag cacgtgaccg gaactacgtc accggatgtg cgtcaccgga 7080 agcatgtgac cggaacttgc gtcacttccc cctcccctga ttggctggtt cgaacgaacg 7140 aaccctccaa tgag 7154 <210> 195 <211> 648 <212> ADN <213> Secuencia Artificial <220> <223> Secuencia de polinucleótidos sintética <400> 195 ctagttatta atagtaatca attacggggt cattagttca tagcccatat atggagttcc 60 gcgttacata acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat 120 tgacgtcaat aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc 180 aatgggtgga gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc 240 caagtacgcc ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt 300 acatgacctt atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta 360 ccatgcatgg tcgaggtgag ccccacgttc tgcttcactc tccccatctc ccccccctcc 420 ccacccccaa ttttgtattt atttattttt taattatttt gtgcagcgat gggggcgggg 480 gggggggggg ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg cggggcgagg 540 cggagaggtg cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc ttttatggcg 600 aggcggcggc ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcg 648 <210> 196 <211> 1428 <212> ADN <213> Secuencia Artificial <220> <223> Secuencia de polinucléotidos sintética <400> 196 atggactaca aagaccatga cggtgattat aaagatcatg atatcgatta caaggatgac 60 gatgacaagg ctgctgtggt tctggaaaat ggcgtgctga gccggaagct gagcgacttc 120 ggacaagaga caagctacat cgaggacaac agcaaccaga atggcgccgt gtctctgatc 180 ttcagcctga aagaagaagt gggcgccctg gccaaggtgc tgagactgtt cgaggaaaac 240 gagatcaatc tgacccacat cgagagcaga cccagcagac tgaacaagga cgagtacgag 300 ttcttcacct acctggacaa gcggagcaag cctgtgctgg gcagcatcat caagagcctg 360 agaaacgaca tcggcgccac cgtgcacgag ctgagcagag acaaagaaaa gaacaccgtg 420 ccatggttcc ccaggaccat ccaagagctg gacagattcg ccaaccagat cctgagctat 480 ggcgccgagc tggacgctga tcaccctggc tttaaggacc ccgtgtaccg ggccagaaga 540 aagcagtttg ccgatatcgc ctacaactac cggcacggcc agcctattcc tcgggtcgag 600 tacaccgagg aagagagaaa gacctggggc accgtgttca gaaccctgaa ggccctgtac 660 aagacccacg cctgctacga gcacaaccac atcttcccac tgctggaaaa gtactgcggc 720 ttccgcgagg acaatatccc tcagctcgaa gacgtgtccc agttcctgca gacctgcacc 780 ggctttagac tgaggcctgt tgccggactg ctgagcagca gagattttct cggcggcctg 840 gccttcagag tgttccactg tacccagtac atcagacacg gcagcaagcc catgtacacc 900 cctgagcctg atatctgcca cgagctgctg ggacatgtgc ccctgttcag cgatagaagc 960 ttcgcccagt tcagccaaga gatcggactg gcttctctgg gagcccctga cgagtacatt 1020 gagaagctgg ccaccatcta ctggttcacc gtggaattcg gcctgtgcaa agagggcgac 1080 agcatcaagg cttatggcgc tggactgctg tctagcttcg gcgagctgca gtactgtctg 1140 agcgacaagc ctaagctgct gcccctggaa ctggaaaaga ccgcctgcca agagtacaca 1200 gtgaccgagt tccagcctct gtactacgtg gccgagagct tcaacgacgc caaagaaaaa 1260 gtgcggacct tcgccgccac cattcctcgg ccttttagcg tcagatacga cccctacaca 1320 cagcgcgtgg aagtgctgga caacacacag cagctgaaga ttctggccga ctccatcaac 1380 agcgaagtgg gcattctgtg tcacgccctg cagaagatca agagctga 1428 <210> 197 <211> 4146 <212> ADN <213> Secuencia Artificial <220> <223> Secuencia de polinucléotidos sintética <400> 197 ctctgggcca gcttgcttgg ggttgccttg acactaagac aagcggcgcg ccgcttgatc 60 ttagtggcac gtcaacccca agcgctggcc cagagccaac cctaattccg gaagtcccgc 120 ccaccggaag tgacgtcaca ggaaatgacg tcacaggaaa tgacgtaatt gtccgccatc 180 ttgtaccgga agtcccgcct accggcggcg accggcggca tctgatttgg tgtcttcttt 240 taaattttgc ggcaattcag tcgataacta taacggtcct aaggtagcga tttaaatacg 300 cgctctctta aggtagcccc gggacgcgtc aattgagatc tggatccggt accgaattcg 360 cggccgcctc gacgactagc gtttagtaat gagacgcaca aactaatatc acaaactgga 420 aatgtctatc aatatatagt tgctctagtt attaatagta atcaattacg gggtcattag 480 ttcatagccc atatatggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct 540 gaccgcccaa cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc 600 caatagggac tttccattga cgtcaatggg tggagtattt acggtaaact gcccacttgg 660 cagtacatca agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat 720 ggcccgcctg gcattatgcc cagtacatga ccttatggga ctttcctact tggcagtaca 780 tctacgtatt agtcatcgct attaccatgc atggtcgagg tgagccccac gttctgcttc 840 actctcccca tctccccccc ctccccaccc ccaattttgt atttatttat tttttaatta 900 ttttgtgcag cgatgggggc gggggggggg ggggggcgcg cgccaggcgg ggcggggcgg 960 ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca gagcggcgcg 1020 ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa aaagcgaagc 1080 gcgcggcggg cgggagtcgc tgcgcgctgc cttcgccccg tgccccgctc cgccgccgcc 1140 tcgcgccgcc cgccccggct ctgactgacc gcgttactcc cacaggtgag cgggcgggac 1200 ggcccttctc cttcgggctg taattagcgc ttggtttaat gacggcttgt ttcttttctg 1260 tggctgcgtg aaagccttga ggggctccgg gagggccctt tgtgcggggg gagcggctcg 1320 gggctgtccg cggggggacg gctgccttcg ggggggacgg ggcagggcgg ggttcggctt 1380 ctggcgtgtg accggcggct ctagagcctc tgctaaccat gttcatgcct tcttcttttt 1440 cctacagctc ctgggcaacg tgctggttat tgtgctgtct catcattttg gcaaagaatt 1500 ggatcgcgaa gccgccacca tggactacaa agaccatgac ggtgattata aagatcatga 1560 tatcgattac aaggatgacg atgacaaggc tgctgtggtt ctggaaaatg gcgtgctgag 1620 ccggaagctg agcgacttcg gacaagagac aagctacatc gaggacaaca gcaaccagaa 1680 tggcgccgtg tctctgatct tcagcctgaa agaagaagtg ggcgccctgg ccaaggtgct 1740 gagactgttc gaggaaaacg agatcaatct gacccacatc gagagcagac ccagcagact 1800 gaacaaggac gagtacgagt tcttcaccta cctggacaag cggagcaagc ctgtgctggg 1860 cagcatcatc aagagcctga gaaacgacat cggcgccacc gtgcacgagc tgagcagaga 1920 caaagaaaag aacaccgtgc catggttccc caggaccatc caagagctgg acagattcgc 1980 caaccagatc ctgagctatg gcgccgagct ggacgctgat caccctggct ttaaggaccc 2040 cgtgtaccgg gccagaagaa agcagtttgc cgatatcgcc tacaactacc ggcacggcca 2100 gcctattcct cgggtcgagt acaccgagga agagagaaag acctggggca ccgtgttcag 2160 aaccctgaag gccctgtaca agacccacgc ctgctacgag cacaaccaca tcttcccact 2220 gctggaaaag tactgcggct tccgcgagga caatatccct cagctcgaag acgtgtccca 2280 gttcctgcag acctgcaccg gctttagact gaggcctgtt gccggactgc tgagcagcag 2340 agattttctc ggcggcctgg ccttcagagt gttccactgt acccagtaca tcagacacgg 2400 cagcaagccc atgtacaccc ctgagcctga tatctgccac gagctgctgg gacatgtgcc 2460 cctgttcagc gatagaagct tcgcccagtt cagccaagag atcggactgg cttctctggg 2520 agcccctgac gagtacattg agaagctggc caccatctac tggttcaccg tggaattcgg 2580 cctgtgcaaa gagggcgaca gcatcaaggc ttatggcgct ggactgctgt ctagcttcgg 2640 cgagctgcag tactgtctga gcgacaagcc taagctgctg cccctggaac tggaaaagac 2700 cgcctgccaa gagtacacag tgaccgagtt ccagcctctg tactacgtgg ccgagagctt 2760 caacgacgcc aaagaaaaag tgcggacctt cgccgccacc attcctcggc cttttagcgt 2820 cagatacgac ccctacacac agcgcgtgga agtgctggac aacacacagc agctgaagat 2880 tctggccgac tccatcaaca gcgaagtggg cattctgtgt cacgccctgc agaagatcaa 2940 gagctgagca agtaatgagc gctgatcata atcaacctct ggattacaaa atttgtgaaa 3000 gattgactgg tattcttaac tatgttgctc cttttacgct atgtggatac gctgctttaa 3060 tgcctttgta tcatgctatt gcttcccgta tggctttcat tttctcctcc ttgtataaat 3120 cctggttgct gtctctttat gaggagttgt ggcccgttgt caggcaacgt ggcgtggtgt 3180 gcactgtgtt tgctgacgca acccccactg gttggggcat tgccaccacc tgtcagctcc 3240 tttccgggac tttcgctttc cccctcccta ttgccacggc ggaactcatc gccgcctgcc 3300 ttgcccgctg ctggacaggg gctcggctgt tgggcactga caattccgtg gtgttgtcgg 3360 ggaaatcatc gtcctttcct tggctgctcg cctgtgttgc cacctggatt ctgcgcggga 3420 cgtccttctg ctacgtccct tcggccctca atccagcgga ccttccttcc cgcggcctgc 3480 tgccggctct gcggcctctt ccgcgtcttc gccttcgccc tcagacgagt cggatctccc 3540 tttgggccgc ctccccgctg atcagcctcg actgtgcctt ctagttgcca gccatctgtt 3600 gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc 3660 taataaaatg aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt 3720 ggggtggggc aggacagcaa gggggaggat tgggaagaca atagcaggca tgctggggat 3780 gcggtgggct ctatggcttc tgaggcggaa agaacgggct cgagaagctt ctagatatcc 3840 tctcttaagg tagcatcgag atttaaatta gggataacag ggtaatggcg cgggccgcaa 3900 aatttaaaag aagacaccaa atcagatgcc gccggtcgcc gccggtaggc gggacttccg 3960 gtacaagatg gcggacaatt acgtcatttc ctgtgacgtc atttcctgtg acgtcacttc 4020 cggtgggcgg gacttccgga attagggttg gctctgggcc agcgcttggg gttgacgtgc 4080 cactaagatc aagcggcgcg ccgcttgtct tagtgtcaag gcaaccccaa gcaagctggc 4140 ccagag 4146 <210> 198 <211> 4214 <212> ADN <213> Secuencia Artificial <220> <223> Secuencia de polinucleótidos sintética <400> 198 cggtgacgtg tttccggctg ttaggttgac cacgcgcatg ccgcgcggtc agcccaatag 60 ttaagccgga aacacgtcac cggaagtcac atgaccggaa gtcacgtgac cggaaacacg 120 tgacaggaag cacgtgaccg gaactacgtc accggatgtg cgtcaccgga agcatgtgac 180 cggaacttgc gtcacttccc cctcccctga ttggctggtt cgaacgaacg aaccctccaa 240 tgagactcaa ggacaagagg atattttgcg cgccaggaag tggcggcaat tcagtcgata 300 actataacgg tcctaaggta gcgatttaaa tacgcgctct cttaaggtag ccccgggacg 360 cgtcaattga gatctggatc cggtaccgaa ttcgcggccg cctcgacgac tagcgtttag 420 taatgagacg cacaaactaa tatcacaaac tggaaatgtc tatcaatata tagttgctct 480 agttattaat agtaatcaat tacggggtca ttagttcata gcccatatat ggagttccgc 540 gttacataac ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg 600 acgtcaataa tgacgtatgt tcccatagta acgccaatag ggactttcca ttgacgtcaa 660 tgggtggagt atttacggta aactgcccac ttggcagtac atcaagtgta tcatatgcca 720 agtacgcccc ctattgacgt caatgacggt aaatggcccg cctggcatta tgcccagtac 780 atgaccttat gggactttcc tacttggcag tacatctacg tattagtcat cgctattacc 840 atgcatggtc gaggtgagcc ccacgttctg cttcactctc cccatctccc ccccctcccc 900 acccccaatt ttgtatttat ttatttttta attattttgt gcagcgatgg gggcgggggg 960 gggggggggg cgcgcgccag gcggggcggg gcggggcgag gggcggggcg gggcgaggcg 1020 gagaggtgcg gcggcagcca atcagagcgg cgcgctccga aagtttcctt ttatggcgag 1080 gcggcggcgg cggcggccct ataaaaagcg aagcgcgcgg cgggcgggag tcgctgcgcg 1140 ctgccttcgc cccgtgcccc gctccgccgc cgcctcgcgc cgcccgcccc ggctctgact 1200 gaccgcgtta ctcccacagg tgagcgggcg ggacggccct tctccttcgg gctgtaatta 1260 gcgcttggtt taatgacggc ttgtttcttt tctgtggctg cgtgaaagcc ttgaggggct 1320 ccgggagggc cctttgtgcg gggggagcgg ctcggggctg tccgcggggg gacggctgcc 1380 ttcggggggg acggggcagg gcggggttcg gcttctggcg tgtgaccggc ggctctagag 1440 cctctgctaa ccatgttcat gccttcttct ttttcctaca gctcctgggc aacgtgctgg 1500 ttattgtgct gtctcatcat tttggcaaag aattggatcg cgaagccgcc accatggact 1560 acaaagacca tgacggtgat tataaagatc atgatatcga ttacaaggat gacgatgaca 1620 aggctgctgt ggttctggaa aatggcgtgc tgagccggaa gctgagcgac ttcggacaag 1680 agacaagcta catcgaggac aacagcaacc agaatggcgc cgtgtctctg atcttcagcc 1740 tgaaagaaga agtgggcgcc ctggccaagg tgctgagact gttcgaggaa aacgagatca 1800 atctgaccca catcgagagc agacccagca gactgaacaa ggacgagtac gagttcttca 1860 cctacctgga caagcggagc aagcctgtgc tgggcagcat catcaagagc ctgagaaacg 1920 acatcggcgc caccgtgcac gagctgagca gagacaaaga aaagaacacc gtgccatggt 1980 tccccaggac catccaagag ctggacagat tcgccaacca gatcctgagc tatggcgccg 2040 agctggacgc tgatcaccct ggctttaagg accccgtgta ccgggccaga agaaagcagt 2100 ttgccgatat cgcctacaac taccggcacg gccagcctat tcctcgggtc gagtacaccg 2160 aggaagagag aaagacctgg ggcaccgtgt tcagaaccct gaaggccctg tacaagaccc 2220 acgcctgcta cgagcacaac cacatcttcc cactgctgga aaagtactgc ggcttccgcg 2280 aggacaatat ccctcagctc gaagacgtgt cccagttcct gcagacctgc accggcttta 2340 gactgaggcc tgttgccgga ctgctgagca gcagagattt tctcggcggc ctggccttca 2400 gagtgttcca ctgtacccag tacatcagac acggcagcaa gcccatgtac acccctgagc 2460 ctgatatctg ccacgagctg ctgggacatg tgcccctgtt cagcgataga agcttcgccc 2520 agttcagcca agagatcgga ctggcttctc tgggagcccc tgacgagtac attgagaagc 2580 tggccaccat ctactggttc accgtggaat tcggcctgtg caaagagggc gacagcatca 2640 aggcttatgg cgctggactg ctgtctagct tcggcgagct gcagtactgt ctgagcgaca 2700 agcctaagct gctgcccctg gaactggaaa agaccgcctg ccaagagtac acagtgaccg 2760 agttccagcc tctgtactac gtggccgaga gcttcaacga cgccaaagaa aaagtgcgga 2820 ccttcgccgc caccattcct cggcctttta gcgtcagata cgacccctac acacagcgcg 2880 tggaagtgct ggacaacaca cagcagctga agattctggc cgactccatc aacagcgaag 2940 tgggcattct gtgtcacgcc ctgcagaaga tcaagagctg agcaagtaat gagcgctgat 3000 cataatcaac ctctggatta caaaatttgt gaaagattga ctggtattct taactatgtt 3060 gctcctttta cgctatgtgg atacgctgct ttaatgcctt tgtatcatgc tattgcttcc 3120 cgtatggctt tcattttctc ctccttgtat aaatcctggt tgctgtctct ttatgaggag 3180 ttgtggcccg ttgtcaggca acgtggcgtg gtgtgcactg tgtttgctga cgcaaccccc 3240 actggttggg gcattgccac cacctgtcag ctcctttccg ggactttcgc tttccccctc 3300 cctattgcca cggcggaact catcgccgcc tgccttgccc gctgctggac aggggctcgg 3360 ctgttgggca ctgacaattc cgtggtgttg tcggggaaat catcgtcctt tccttggctg 3420 ctcgcctgtg ttgccacctg gattctgcgc gggacgtcct tctgctacgt cccttcggcc 3480 ctcaatccag cggaccttcc ttcccgcggc ctgctgccgg ctctgcggcc tcttccgcgt 3540 cttcgccttc gccctcagac gagtcggatc tccctttggg ccgcctcccc gctgatcagc 3600 ctcgactgtg ccttctagtt gccagccatc tgttgtttgc ccctcccccg tgccttcctt 3660 gaccctggaa ggtgccactc ccactgtcct ttcctaataa aatgaggaaa ttgcatcgca 3720 ttgtctgagt aggtgtcatt ctattctggg gggtggggtg gggcaggaca gcaaggggga 3780 ggattgggaa gacaatagca ggcatgctgg ggatgcggtg ggctctatgg cttctgaggc 3840 ggaaagaacg ggctcgagaa gcttctagat atcctctctt aaggtagcat cgagatttaa 3900 attagggata acagggtaat ggcgcgggcc gccacttcct ggcgcgcaaa atatcctctt 3960 gtccttgagt ctcattggag ggttcgttcg ttcgaaccag ccaatcaggg gagggggaag 4020 tgacgcaagt tccggtcaca tgcttccggt gacgcacatc cggtgacgta gttccggtca 4080 cgtgcttcct gtcacgtgtt tccggtcacg tgacttccgg tcatgtgact tccggtgacg 4140 tgtttccggc ttaactattg ggctgaccgc gcggcatgcg cgtggtcaac ctaacagccg 4200 gaaacacgtc accg 4214