LISTA DE SECUENCIAS <110> Sanofi <120> PROTEÍNAS DE UNIÓN ANTI-CD38, ANTI-CD28, Y ANTI-CD3 TRIESPECÍFICAS Y MÉTODOS DE USO PARA EL TRATAMIENTO DE UNA INFECCIÓN VIRAL <130> 18395-20321.40 <140> Todavía No Cedida <141> En tramitación con la Presente <150> EP 19306097.7 <151> 11-09-2019 <150> US 62/831.608 <151> 04-09-2019 <150> US 62/831.572 <151> 04-09-2019 <150> PCT/US2018/055084 <151> 10-09-2018 <160> 132 <170> FastSEQ para Windows Versión 4.0 <210> 1 <211> 256 <212> PRT <213> Homo sapiens <400> 1 Arg Trp Arg Gln Gln Trp Ser Gly Pro Gly Thr Thr Lys Arg Phe Pro 1 5 10 15 Glu Thr Val Leu Ala Arg Cys Val Lys Tyr Thr Glu Ile His Pro Glu 20 25 30 Met Arg His Val Asp Cys Gln Ser Val Trp Asp Ala Phe Lys Gly Ala 35 40 45 Phe Ile Ser Lys His Pro Cys Asn Ile Thr Glu Glu Asp Tyr Gln Pro 50 55 60 Leu Met Lys Leu Gly Thr Gln Thr Val Pro Cys Asn Lys Ile Leu Leu 65 70 75 80 Trp Ser Arg Ile Lys Asp Leu Ala His Gln Phe Thr Gln Val Gln Arg 85 90 95 Asp Met Phe Thr Leu Glu Asp Thr Leu Leu Gly Tyr Leu Ala Asp Asp 100 105 110 Leu Thr Trp Cys Gly Glu Phe Asn Thr Ser Lys Ile Asn Tyr Gln Ser 115 120 125 Cys Pro Asp Trp Arg Lys Asp Cys Ser Asn Asn Pro Val Ser Val Phe 130 135 140 Trp Lys Thr Val Ser Arg Arg Phe Ala Glu Ala Ala Cys Asp Val Val 145 150 155 160 His Val Met Leu Asn Gly Ser Arg Ser Lys Ile Phe Asp Lys Asn Ser 165 170 175 Thr Phe Gly Ser Val Glu Val His Asn Leu Gln Pro Glu Lys Val Gln 180 185 190 Thr Leu Glu Ala Trp Val Ile His Gly Gly Arg Glu Asp Ser Arg Asp 195 200 205 Leu Cys Gln Asp Pro Thr Ile Lys Glu Leu Glu Ser Ile Ile Ser Lys 210 215 220 Arg Asn Ile Gln Phe Ser Cys Lys Asn Ile Tyr Arg Pro Asp Lys Phe 225 230 235 240 Leu Gln Cys Val Lys Asn Pro Glu Asp Ser Ser Cys Thr Ser Glu Ile 245 250 255 <210> 2 <211> 265 <212> PRT <213> Homo sapiens <400> 2 Arg Trp Arg Gln Gln Trp Ser Gly Pro Gly Thr Thr Lys Arg Phe Pro 1 5 10 15 Glu Thr Val Leu Ala Arg Cys Val Lys Tyr Thr Glu Ile His Pro Glu 20 25 30 Met Arg His Val Asp Cys Gln Ser Val Trp Asp Ala Phe Lys Gly Ala 35 40 45 Phe Ile Ser Lys His Pro Cys Asn Ile Thr Glu Glu Asp Tyr Gln Pro 50 55 60 Leu Met Lys Leu Gly Thr Gln Thr Val Pro Cys Asn Lys Ile Leu Leu 65 70 75 80 Trp Ser Arg Ile Lys Asp Leu Ala His Gln Phe Thr Gln Val Gln Arg 85 90 95 Asp Met Phe Thr Leu Glu Asp Thr Leu Leu Gly Tyr Leu Ala Asp Asp 100 105 110 Leu Thr Trp Cys Gly Glu Phe Asn Thr Ser Lys Ile Asn Tyr Gln Ser 115 120 125 Cys Pro Asp Trp Arg Lys Asp Cys Ser Asn Asn Pro Val Ser Val Phe 130 135 140 Trp Lys Thr Val Ser Arg Arg Phe Ala Glu Ala Ala Cys Asp Val Val 145 150 155 160 His Val Met Leu Asn Gly Ser Arg Ser Lys Ile Phe Asp Lys Asn Ser 165 170 175 Thr Phe Gly Ser Val Glu Val His Asn Leu Gln Pro Glu Lys Val Gln 180 185 190 Thr Leu Glu Ala Trp Val Ile His Gly Gly Arg Glu Asp Ser Arg Asp 195 200 205 Leu Cys Gln Asp Pro Thr Ile Lys Glu Leu Glu Ser Ile Ile Ser Lys 210 215 220 Arg Asn Ile Gln Phe Ser Cys Lys Asn Ile Tyr Arg Pro Asp Lys Phe 225 230 235 240 Leu Gln Cys Val Lys Asn Pro Glu Asp Ser Ser Cys Thr Ser Glu Ile 245 250 255 Ser Ala Ser His His His His His His 260 265 <210> 3 <400> 3 000 <210> 4 <211> 265 <212> PRT <213> Macaca fascicularis <400> 4 Arg Trp Arg Gln Gln Trp Ser Gly Ser Gly Thr Thr Ser Arg Phe Pro 1 5 10 15 Glu Thr Val Leu Ala Arg Cys Val Lys Tyr Thr Glu Val His Pro Glu 20 25 30 Met Arg His Val Asp Cys Gln Ser Val Trp Asp Ala Phe Lys Gly Ala 35 40 45 Phe Ile Ser Lys Tyr Pro Cys Asn Ile Thr Glu Glu Asp Tyr Gln Pro 50 55 60 Leu Val Lys Leu Gly Thr Gln Thr Val Pro Cys Asn Lys Thr Leu Leu 65 70 75 80 Trp Ser Arg Ile Lys Asp Leu Ala His Gln Phe Thr Gln Val Gln Arg 85 90 95 Asp Met Phe Thr Leu Glu Asp Met Leu Leu Gly Tyr Leu Ala Asp Asp 100 105 110 Leu Thr Trp Cys Gly Glu Phe Asn Thr Phe Glu Ile Asn Tyr Gln Ser 115 120 125 Cys Pro Asp Trp Arg Lys Asp Cys Ser Asn Asn Pro Val Ser Val Phe 130 135 140 Trp Lys Thr Val Ser Arg Arg Phe Ala Glu Thr Ala Cys Gly Val Val 145 150 155 160 His Val Met Leu Asn Gly Ser Arg Ser Lys Ile Phe Asp Lys Asn Ser 165 170 175 Thr Phe Gly Ser Val Glu Val His Asn Leu Gln Pro Glu Lys Val Gln 180 185 190 Ala Leu Glu Ala Trp Val Ile His Gly Gly Arg Glu Asp Ser Arg Asp 195 200 205 Leu Cys Gln Asp Pro Thr Ile Lys Glu Leu Glu Ser Ile Ile Ser Lys 210 215 220 Arg Asn Ile Arg Phe Phe Cys Lys Asn Ile Tyr Arg Pro Asp Lys Phe 225 230 235 240 Leu Gln Cys Val Lys Asn Pro Glu Asp Ser Ser Cys Leu Ser Gly Ile 245 250 255 Ser Ala Ser His His His His His His 260 265 <210> 5 <211> 119 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 5 Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Ser Gly Ala 1 5 10 15 Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Phe 20 25 30 Asn Met His Trp Val Lys Glu Thr Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Pro Gly Asn Gly Gly Thr Asn Tyr Asn Gln Lys Phe 50 55 60 Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Gln Ile Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 85 90 95 Ala Arg Thr Gly Gly Leu Arg Arg Ala Tyr Phe Thr Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser 115 <210> 6 <211> 111 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 6 Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 20 25 30 Gly Asn Gly Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 35 40 45 Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 50 55 60 Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 65 70 75 80 Pro Val Glu Ala Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Lys 85 90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 7 <211> 449 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 7 Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Ser Gly Ala 1 5 10 15 Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Phe 20 25 30 Asn Met His Trp Val Lys Glu Thr Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Pro Gly Asn Gly Gly Thr Asn Tyr Asn Gln Lys Phe 50 55 60 Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Gln Ile Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 85 90 95 Ala Arg Thr Gly Gly Leu Arg Arg Ala Tyr Phe Thr Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 115 120 125 Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 130 135 140 Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 145 150 155 160 Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 165 170 175 Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 180 185 190 Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 195 200 205 Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 210 215 220 Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Ala Gly 225 230 235 240 Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 245 250 255 Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 260 265 270 Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 275 280 285 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 290 295 300 Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 305 310 315 320 Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Leu Pro Glu Glu 325 330 335 Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 340 345 350 Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 355 360 365 Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 370 375 380 Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 385 390 395 400 Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 405 410 415 Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 420 425 430 Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 435 440 445 Gly <210> 8 <211> 218 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 8 Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 20 25 30 Gly Asn Gly Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 35 40 45 Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 50 55 60 Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 65 70 75 80 Pro Val Glu Ala Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Lys 85 90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 100 105 110 Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 115 120 125 Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 130 135 140 Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 145 150 155 160 Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 165 170 175 Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 180 185 190 His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 195 200 205 Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 210 215 <210> 9 <211> 117 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 9 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Gly Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Met Phe Arg Gly Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 <210> 10 <211> 107 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 10 Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 20 25 30 Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Gly Leu Gln Pro 65 70 75 80 Glu Asp Ser Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Ile Tyr Tyr Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 11 <211> 446 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 11 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Gly Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Met Phe Arg Gly Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 115 120 125 Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 130 135 140 Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 145 150 155 160 Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 165 170 175 Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 180 185 190 Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 195 200 205 Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 210 215 220 Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Ala Gly Pro Asp Val 225 230 235 240 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 245 250 255 Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 260 265 270 Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 275 280 285 Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 290 295 300 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 305 310 315 320 Cys Lys Val Ser Asn Lys Ala Leu Pro Leu Pro Glu Glu Lys Thr Ile 325 330 335 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 340 345 350 Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 355 360 365 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 370 375 380 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 385 390 395 400 Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 405 410 415 Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 420 425 430 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 435 440 445 <210> 12 <211> 214 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 12 Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 20 25 30 Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Gly Leu Gln Pro 65 70 75 80 Glu Asp Ser Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Ile Tyr Tyr Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 100 105 110 Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 115 120 125 Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 130 135 140 Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 145 150 155 160 Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 165 170 175 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 180 185 190 Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 195 200 205 Phe Asn Arg Gly Glu Cys 210 <210> 13 <211> 120 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 13 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Ala Met His Trp Val Lys Glu Ala Pro Gly Gln Arg Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Pro Gly Gln Gly Gly Thr Asn Tyr Asn Gln Lys Phe 50 55 60 Gln Gly Arg Ala Thr Leu Thr Ala Asp Thr Ser Ala Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Arg Thr Gly Gly Leu Arg Arg Ala Tyr Phe Thr Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 14 <211> 111 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 14 Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Gly Gln Gly Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 35 40 45 Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Ala 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 65 70 75 80 Pro Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Lys 85 90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 15 <211> 449 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 15 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Ala Met His Trp Val Lys Glu Ala Pro Gly Gln Arg Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Pro Gly Gln Gly Gly Thr Asn Tyr Asn Gln Lys Phe 50 55 60 Gln Gly Arg Ala Thr Leu Thr Ala Asp Thr Ser Ala Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Arg Thr Gly Gly Leu Arg Arg Ala Tyr Phe Thr Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 115 120 125 Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 130 135 140 Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 145 150 155 160 Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 165 170 175 Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 180 185 190 Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 195 200 205 Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 210 215 220 Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Ala Gly 225 230 235 240 Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 245 250 255 Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 260 265 270 Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 275 280 285 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 290 295 300 Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 305 310 315 320 Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Leu Pro Glu Glu 325 330 335 Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 340 345 350 Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 355 360 365 Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 370 375 380 Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 385 390 395 400 Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 405 410 415 Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 420 425 430 Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 435 440 445 Gly <210> 16 <211> 218 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 16 Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Gly Gln Gly Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 35 40 45 Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Ala 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 65 70 75 80 Pro Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Lys 85 90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 100 105 110 Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 115 120 125 Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 130 135 140 Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 145 150 155 160 Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 165 170 175 Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 180 185 190 His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 195 200 205 Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 210 215 <210> 17 <211> 120 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 17 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Phe 20 25 30 Asn Met His Trp Val Lys Glu Ala Pro Gly Gln Arg Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Pro Gly Asn Gly Gly Thr Asn Tyr Asn Gln Lys Phe 50 55 60 Gln Gly Arg Ala Thr Leu Thr Ala Asp Thr Ser Ala Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Arg Thr Gly Gly Leu Arg Arg Ala Tyr Phe Thr Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 18 <211> 111 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 18 Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 20 25 30 Gly Asn Gly Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 35 40 45 Arg Leu Leu Ile Tyr Leu Ala Ser Ser Arg Ala Thr Gly Ile Pro Ala 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 65 70 75 80 Pro Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Lys 85 90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 19 <211> 449 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 19 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Phe 20 25 30 Asn Met His Trp Val Lys Glu Ala Pro Gly Gln Arg Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Pro Gly Asn Gly Gly Thr Asn Tyr Asn Gln Lys Phe 50 55 60 Gln Gly Arg Ala Thr Leu Thr Ala Asp Thr Ser Ala Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Arg Thr Gly Gly Leu Arg Arg Ala Tyr Phe Thr Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 115 120 125 Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 130 135 140 Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 145 150 155 160 Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 165 170 175 Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 180 185 190 Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 195 200 205 Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 210 215 220 Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Ala Gly 225 230 235 240 Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 245 250 255 Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 260 265 270 Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 275 280 285 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 290 295 300 Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 305 310 315 320 Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Leu Pro Glu Glu 325 330 335 Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 340 345 350 Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 355 360 365 Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 370 375 380 Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 385 390 395 400 Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 405 410 415 Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 420 425 430 Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 435 440 445 Gly <210> 20 <211> 218 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 20 Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 20 25 30 Gly Asn Gly Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 35 40 45 Arg Leu Leu Ile Tyr Leu Ala Ser Ser Arg Ala Thr Gly Ile Pro Ala 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 65 70 75 80 Pro Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Lys 85 90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 100 105 110 Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 115 120 125 Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 130 135 140 Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 145 150 155 160 Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 165 170 175 Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 180 185 190 His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 195 200 205 Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 210 215 <210> 21 <211> 120 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 21 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Ser Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Phe 20 25 30 Asn Met His Trp Val Lys Glu Ala Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Pro Gly Asn Gly Gly Thr Asn Tyr Asn Gln Lys Phe 50 55 60 Gln Gly Arg Ala Thr Leu Thr Ala Asp Thr Ser Ala Ser Thr Ala Tyr 65 70 75 80 Met Glu Ile Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Arg Thr Gly Gly Leu Arg Arg Ala Tyr Phe Thr Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 22 <211> 449 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 22 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Ser Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Phe 20 25 30 Asn Met His Trp Val Lys Glu Ala Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Pro Gly Asn Gly Gly Thr Asn Tyr Asn Gln Lys Phe 50 55 60 Gln Gly Arg Ala Thr Leu Thr Ala Asp Thr Ser Ala Ser Thr Ala Tyr 65 70 75 80 Met Glu Ile Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Arg Thr Gly Gly Leu Arg Arg Ala Tyr Phe Thr Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 115 120 125 Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 130 135 140 Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 145 150 155 160 Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 165 170 175 Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 180 185 190 Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 195 200 205 Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 210 215 220 Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Ala Gly 225 230 235 240 Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 245 250 255 Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 260 265 270 Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 275 280 285 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 290 295 300 Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 305 310 315 320 Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Leu Pro Glu Glu 325 330 335 Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 340 345 350 Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 355 360 365 Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 370 375 380 Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 385 390 395 400 Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 405 410 415 Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 420 425 430 Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 435 440 445 Gly <210> 23 <211> 120 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 23 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Phe 20 25 30 Asn Met His Trp Val Lys Glu Ala Pro Gly Gln Arg Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Pro Gly Asn Gly Gly Thr Asn Tyr Asn Gln Lys Phe 50 55 60 Gln Gly Arg Ala Thr Leu Thr Ala Asp Thr Ser Ala Ser Thr Ala Tyr 65 70 75 80 Met Glu Ile Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Arg Thr Gly Gly Leu Arg Arg Ala Tyr Phe Thr Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 24 <211> 449 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 24 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Phe 20 25 30 Asn Met His Trp Val Lys Glu Ala Pro Gly Gln Arg Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Pro Gly Asn Gly Gly Thr Asn Tyr Asn Gln Lys Phe 50 55 60 Gln Gly Arg Ala Thr Leu Thr Ala Asp Thr Ser Ala Ser Thr Ala Tyr 65 70 75 80 Met Glu Ile Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Arg Thr Gly Gly Leu Arg Arg Ala Tyr Phe Thr Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 115 120 125 Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 130 135 140 Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 145 150 155 160 Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 165 170 175 Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 180 185 190 Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 195 200 205 Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 210 215 220 Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Ala Gly 225 230 235 240 Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 245 250 255 Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 260 265 270 Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 275 280 285 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 290 295 300 Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 305 310 315 320 Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Leu Pro Glu Glu 325 330 335 Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 340 345 350 Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 355 360 365 Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 370 375 380 Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 385 390 395 400 Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 405 410 415 Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 420 425 430 Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 435 440 445 Gly <210> 25 <211> 9 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 25 Ser Leu Tyr Asn Thr Val Ala Thr Leu 1 5 <210> 26 <211> 9 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 26 Asn Leu Val Pro Met Val Ala Thr Val 1 5 <210> 27 <211> 9 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 27 Gly Leu Cys Thr Leu Val Ala Met Leu 1 5 <210> 28 <211> 9 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 28 Gly Ile Leu Gly Phe Val Phe Thr Leu 1 5 <210> 29 <400> 29 000 <210> 30 <211> 256 <212> PRT <213> Macaca fascicularis <400> 30 Arg Trp Arg Gln Gln Trp Ser Gly Ser Gly Thr Thr Ser Arg Phe Pro 1 5 10 15 Glu Thr Val Leu Ala Arg Cys Val Lys Tyr Thr Glu Val His Pro Glu 20 25 30 Met Arg His Val Asp Cys Gln Ser Val Trp Asp Ala Phe Lys Gly Ala 35 40 45 Phe Ile Ser Lys Tyr Pro Cys Asn Ile Thr Glu Glu Asp Tyr Gln Pro 50 55 60 Leu Val Lys Leu Gly Thr Gln Thr Val Pro Cys Asn Lys Thr Leu Leu 65 70 75 80 Trp Ser Arg Ile Lys Asp Leu Ala His Gln Phe Thr Gln Val Gln Arg 85 90 95 Asp Met Phe Thr Leu Glu Asp Met Leu Leu Gly Tyr Leu Ala Asp Asp 100 105 110 Leu Thr Trp Cys Gly Glu Phe Asn Thr Phe Glu Ile Asn Tyr Gln Ser 115 120 125 Cys Pro Asp Trp Arg Lys Asp Cys Ser Asn Asn Pro Val Ser Val Phe 130 135 140 Trp Lys Thr Val Ser Arg Arg Phe Ala Glu Thr Ala Cys Gly Val Val 145 150 155 160 His Val Met Leu Asn Gly Ser Arg Ser Lys Ile Phe Asp Lys Asn Ser 165 170 175 Thr Phe Gly Ser Val Glu Val His Asn Leu Gln Pro Glu Lys Val Gln 180 185 190 Ala Leu Glu Ala Trp Val Ile His Gly Gly Arg Glu Asp Ser Arg Asp 195 200 205 Leu Cys Gln Asp Pro Thr Ile Lys Glu Leu Glu Ser Ile Ile Ser Lys 210 215 220 Arg Asn Ile Arg Phe Phe Cys Lys Asn Ile Tyr Arg Pro Asp Lys Phe 225 230 235 240 Leu Gln Cys Val Lys Asn Pro Glu Asp Ser Ser Cys Leu Ser Gly Ile 245 250 255 <210> 31 <211> 8 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 31 Gly Tyr Thr Phe Thr Ser Phe Asn 1 5 <210> 32 <211> 8 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 32 Ile Tyr Pro Gly Asn Gly Gly Thr 1 5 <210> 33 <211> 13 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 33 Ala Arg Thr Gly Gly Leu Arg Arg Ala Tyr Phe Thr Tyr 1 5 10 <210> 34 <211> 10 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 34 Glu Ser Val Asp Ser Tyr Gly Asn Gly Phe 1 5 10 <210> 35 <211> 3 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 35 Leu Ala Ser 1 <210> 36 <211> 9 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 36 Gln Gln Asn Lys Glu Asp Pro Trp Thr 1 5 <210> 37 <211> 8 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 37 Gly Tyr Thr Phe Thr Ser Tyr Ala 1 5 <210> 38 <211> 8 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 38 Ile Tyr Pro Gly Gln Gly Gly Thr 1 5 <210> 39 <211> 10 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 39 Gln Ser Val Ser Ser Tyr Gly Gln Gly Phe 1 5 10 <210> 40 <211> 3 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 40 Gly Ala Ser 1 <210> 41 <211> 8 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 41 Gly Phe Thr Phe Ser Ser Tyr Gly 1 5 <210> 42 <211> 8 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 42 Ile Trp Tyr Asp Gly Ser Asn Lys 1 5 <210> 43 <211> 10 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 43 Ala Arg Met Phe Arg Gly Ala Phe Asp Tyr 1 5 10 <210> 44 <211> 6 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 44 Gln Gly Ile Arg Asn Asp 1 5 <210> 45 <211> 3 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 45 Ala Ala Ser 1 <210> 46 <211> 9 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 46 Leu Gln Asp Tyr Ile Tyr Tyr Pro Thr 1 5 <210> 47 <211> 120 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 47 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Ala Lys Pro Gly Thr 1 5 10 15 Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 20 25 30 Trp Met Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Thr Ile Tyr Pro Gly Asp Gly Asp Thr Gly Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Lys Thr Val Tyr 65 70 75 80 Met His Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Asn Ser Leu Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Ser Val Thr Val Ser Ser 115 120 <210> 48 <211> 107 <212> PRT <213> Secuencia Artificial <220> <223> Construccción Sintética <400> 48 Asp Ile Val Met Thr Gln Ser His Leu Ser Met Ser Thr Ser Leu Gly 1 5 10 15 Asp Pro Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Val 20 25 30 Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Arg Arg Leu Ile 35 40 45 Tyr Ser Ala Ser Tyr Arg Tyr Ile Gly Val Pro Asp Arg Phe Thr Gly 50 55 60 Ser Gly Ala Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala 65 70 75 80 Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Pro Pro Tyr 85 90 95 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 49 <211> 120 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 49 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Ser Ile Tyr Pro Gly Asn Val Asn Thr Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Ala Thr Leu Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Thr Arg Ser His Tyr Gly Leu Asp Trp Asn Phe Asp Val Trp Gly Lys 100 105 110 Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 50 <211> 107 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 50 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile Tyr Val Trp 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Thr Tyr Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 51 <211> 119 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 51 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Asp Tyr 20 25 30 Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 35 40 45 Gly Val Ile Trp Ala Gly Gly Gly Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Lys Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Lys Gly Tyr Ser Tyr Tyr Tyr Ser Met Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Thr Val Thr Val Ser 115 <210> 52 <211> 111 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 52 Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 1 5 10 15 Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr 20 25 30 Val Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 35 40 45 Lys Leu Leu Ile Phe Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 65 70 75 80 Pro Val Glu Ala Asn Asp Val Ala Asn Tyr Tyr Cys Gln Gln Ser Arg 85 90 95 Lys Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 53 <211> 121 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 53 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Lys Ala 20 25 30 Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gln Leu Glu Trp Val 35 40 45 Ala Gln Ile Lys Asp Lys Ser Asn Ser Tyr Ala Thr Tyr Tyr Ala Asp 50 55 60 Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Arg Gly Val Tyr Tyr Ala Leu Ser Pro Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 54 <211> 112 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 54 Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 1 5 10 15 Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Val His Asn 20 25 30 Asn Ala Asn Thr Tyr Leu Ser Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Ser Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gly Gln Gly 85 90 95 Thr Gln Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 55 <211> 10 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 55 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 1 5 10 <210> 56 <211> 15 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 56 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 1 5 10 15 <210> 57 <211> 5 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 57 Thr Lys Gly Pro Ser 1 5 <210> 58 <211> 7 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 58 Gly Gln Pro Lys Ala Ala Pro 1 5 <210> 59 <211> 10 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 59 Gly Gly Ser Gly Ser Ser Gly Ser Gly Gly 1 5 10 <210> 60 <211> 570 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 60 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Ser Ile Tyr Pro Gly Asn Val Asn Thr Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Ala Thr Leu Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Thr Arg Ser His Tyr Gly Leu Asp Trp Asn Phe Asp Val Trp Gly Lys 100 105 110 Gly Thr Thr Val Thr Val Ser Ser Ser Gln Val Gln Leu Val Glu Ser 115 120 125 Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala 130 135 140 Ala Ser Gly Phe Thr Phe Thr Lys Ala Trp Met His Trp Val Arg Gln 145 150 155 160 Ala Pro Gly Lys Gln Leu Glu Trp Val Ala Gln Ile Lys Asp Lys Ser 165 170 175 Asn Ser Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 180 185 190 Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 195 200 205 Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Arg Gly Val Tyr Tyr 210 215 220 Ala Leu Ser Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 225 230 235 240 Ser Ser Arg Thr Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 245 250 255 Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 260 265 270 Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 275 280 285 Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 290 295 300 Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 305 310 315 320 Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 325 330 335 Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 340 345 350 Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 355 360 365 Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 370 375 380 Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 385 390 395 400 Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 405 410 415 Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 420 425 430 Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 435 440 445 Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 450 455 460 Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Gln Glu 465 470 475 480 Glu Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe 485 490 495 Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 500 505 510 Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 515 520 525 Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 530 535 540 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 545 550 555 560 Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 565 570 <210> 61 <211> 338 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 61 Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 1 5 10 15 Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Val His Asn 20 25 30 Asn Ala Asn Thr Tyr Leu Ser Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Ser Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gly Gln Gly 85 90 95 Thr Gln Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Val Glu Ile Lys 100 105 110 Gly Gln Pro Lys Ala Ala Pro Asp Ile Gln Met Thr Gln Ser Pro Ser 115 120 125 Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala 130 135 140 Ser Gln Asn Ile Tyr Val Trp Leu Asn Trp Tyr Gln Gln Lys Pro Gly 145 150 155 160 Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Asn Leu His Thr Gly 165 170 175 Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 180 185 190 Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln 195 200 205 Gln Gly Gln Thr Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 210 215 220 Ile Lys Thr Lys Gly Pro Ser Arg Thr Val Ala Ala Pro Ser Val Phe 225 230 235 240 Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val 245 250 255 Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp 260 265 270 Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr 275 280 285 Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr 290 295 300 Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val 305 310 315 320 Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly 325 330 335 Glu Cys <210> 62 <211> 446 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 62 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Ala Met His Trp Val Lys Glu Ala Pro Gly Gln Arg Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Pro Gly Gln Gly Gly Thr Asn Tyr Asn Gln Lys Phe 50 55 60 Gln Gly Arg Ala Thr Leu Thr Ala Asp Thr Ser Ala Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Arg Thr Gly Gly Leu Arg Arg Ala Tyr Phe Thr Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 115 120 125 Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 130 135 140 Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 145 150 155 160 Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 165 170 175 Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 180 185 190 Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 195 200 205 Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 210 215 220 Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 225 230 235 240 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 245 250 255 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 260 265 270 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 275 280 285 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 290 295 300 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 305 310 315 320 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 325 330 335 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 340 345 350 Pro Cys Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu 355 360 365 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 370 375 380 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 385 390 395 400 Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 405 410 415 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 420 425 430 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 435 440 445 <210> 63 <211> 218 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 63 Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Gly Gln Gly Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 35 40 45 Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Ala 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 65 70 75 80 Pro Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Lys 85 90 95 Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 100 105 110 Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 115 120 125 Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 130 135 140 Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 145 150 155 160 Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 165 170 175 Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 180 185 190 His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 195 200 205 Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 210 215 <210> 64 <211> 573 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 64 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Ser Ile Tyr Pro Gly Asn Val Asn Thr Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Ala Thr Leu Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Thr Arg Ser His Tyr Gly Leu Asp Trp Asn Phe Asp Val Trp Gly Lys 100 105 110 Gly Thr Thr Val Thr Val Ser Ser Ser Gln Val Gln Leu Val Glu Ser 115 120 125 Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala 130 135 140 Ala Ser Gly Phe Thr Phe Thr Lys Ala Trp Met His Trp Val Arg Gln 145 150 155 160 Ala Pro Gly Lys Gln Leu Glu Trp Val Ala Gln Ile Lys Asp Lys Ser 165 170 175 Asn Ser Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 180 185 190 Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 195 200 205 Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Arg Gly Val Tyr Tyr 210 215 220 Ala Leu Ser Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 225 230 235 240 Ser Ser Arg Thr Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 245 250 255 Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 260 265 270 Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 275 280 285 Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 290 295 300 Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 305 310 315 320 Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 325 330 335 Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 340 345 350 Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 355 360 365 Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 370 375 380 Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 385 390 395 400 Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 405 410 415 Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 420 425 430 Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 435 440 445 Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser 450 455 460 Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro 465 470 475 480 Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val 485 490 495 Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 500 505 510 Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 515 520 525 Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 530 535 540 Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 545 550 555 560 Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 565 570 <210> 65 <211> 449 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 65 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Ala Met His Trp Val Lys Glu Ala Pro Gly Gln Arg Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Pro Gly Gln Gly Gly Thr Asn Tyr Asn Gln Lys Phe 50 55 60 Gln Gly Arg Ala Thr Leu Thr Ala Asp Thr Ser Ala Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Arg Thr Gly Gly Leu Arg Arg Ala Tyr Phe Thr Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 115 120 125 Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 130 135 140 Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 145 150 155 160 Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 165 170 175 Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 180 185 190 Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 195 200 205 Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 210 215 220 Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 225 230 235 240 Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 245 250 255 Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 260 265 270 Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 275 280 285 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 290 295 300 Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 305 310 315 320 Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu 325 330 335 Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 340 345 350 Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 355 360 365 Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 370 375 380 Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 385 390 395 400 Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 405 410 415 Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 420 425 430 Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 435 440 445 Gly <210> 66 <211> 573 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 66 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Ser Ile Tyr Pro Gly Asn Val Asn Thr Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Ala Thr Leu Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Thr Arg Ser His Tyr Gly Leu Asp Trp Asn Phe Asp Val Trp Gly Lys 100 105 110 Gly Thr Thr Val Thr Val Ser Ser Ser Gln Val Gln Leu Val Glu Ser 115 120 125 Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala 130 135 140 Ala Ser Gly Phe Thr Phe Thr Lys Ala Trp Met His Trp Val Arg Gln 145 150 155 160 Ala Pro Gly Lys Gln Leu Glu Trp Val Ala Gln Ile Lys Asp Lys Ser 165 170 175 Asn Ser Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 180 185 190 Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 195 200 205 Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Arg Gly Val Tyr Tyr 210 215 220 Ala Leu Ser Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 225 230 235 240 Ser Ser Arg Thr Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 245 250 255 Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 260 265 270 Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 275 280 285 Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 290 295 300 Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 305 310 315 320 Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 325 330 335 Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 340 345 350 Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 355 360 365 Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 370 375 380 Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 385 390 395 400 Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 405 410 415 Lys Pro Arg Glu Glu Gln Tyr Asn Asn Ala Ser Arg Val Val Ser Val 420 425 430 Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 435 440 445 Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 450 455 460 Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro 465 470 475 480 Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val 485 490 495 Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 500 505 510 Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 515 520 525 Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 530 535 540 Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 545 550 555 560 Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 565 570 <210> 67 <211> 449 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 67 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Ala Met His Trp Val Lys Glu Ala Pro Gly Gln Arg Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Pro Gly Gln Gly Gly Thr Asn Tyr Asn Gln Lys Phe 50 55 60 Gln Gly Arg Ala Thr Leu Thr Ala Asp Thr Ser Ala Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Arg Thr Gly Gly Leu Arg Arg Ala Tyr Phe Thr Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 115 120 125 Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 130 135 140 Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 145 150 155 160 Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 165 170 175 Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 180 185 190 Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 195 200 205 Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 210 215 220 Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 225 230 235 240 Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 245 250 255 Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 260 265 270 Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 275 280 285 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Asn Ala Ser Arg 290 295 300 Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 305 310 315 320 Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 325 330 335 Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 340 345 350 Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 355 360 365 Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 370 375 380 Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 385 390 395 400 Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 405 410 415 Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 420 425 430 Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 435 440 445 Gly <210> 68 <211> 443 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 68 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Gly Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Met Phe Arg Gly Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 115 120 125 Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 130 135 140 Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 145 150 155 160 Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 165 170 175 Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 180 185 190 Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 195 200 205 Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 210 215 220 Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 225 230 235 240 Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 245 250 255 Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 260 265 270 Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 275 280 285 Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 290 295 300 Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 305 310 315 320 Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 325 330 335 Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Gln 340 345 350 Glu Glu Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly 355 360 365 Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 370 375 380 Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 385 390 395 400 Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 405 410 415 Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 420 425 430 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 435 440 <210> 69 <211> 214 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 69 Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 20 25 30 Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Gly Leu Gln Pro 65 70 75 80 Glu Asp Ser Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Ile Tyr Tyr Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 100 105 110 Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 115 120 125 Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 130 135 140 Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 145 150 155 160 Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 165 170 175 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 180 185 190 Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 195 200 205 Phe Asn Arg Gly Glu Cys 210 <210> 70 <211> 446 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 70 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Gly Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Met Phe Arg Gly Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 115 120 125 Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 130 135 140 Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 145 150 155 160 Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 165 170 175 Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 180 185 190 Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 195 200 205 Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 210 215 220 Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 225 230 235 240 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 245 250 255 Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 260 265 270 Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 275 280 285 Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 290 295 300 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 305 310 315 320 Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys Thr Ile 325 330 335 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 340 345 350 Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu 355 360 365 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 370 375 380 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 385 390 395 400 Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 405 410 415 Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 420 425 430 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 435 440 445 <210> 71 <211> 446 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 71 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Gly Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Met Phe Arg Gly Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 115 120 125 Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 130 135 140 Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 145 150 155 160 Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 165 170 175 Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 180 185 190 Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 195 200 205 Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 210 215 220 Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 225 230 235 240 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 245 250 255 Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 260 265 270 Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 275 280 285 Thr Lys Pro Arg Glu Glu Gln Tyr Asn Asn Ala Ser Arg Val Val Ser 290 295 300 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 305 310 315 320 Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 325 330 335 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 340 345 350 Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu 355 360 365 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 370 375 380 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 385 390 395 400 Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 405 410 415 Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 420 425 430 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 435 440 445 <210> 72 <211> 1710 <212> ADN <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 72 caggtgcagc tggtgcagtc tggcgccgag gtcgtgaaac ctggcgcctc tgtgaaggtg 60 tcctgcaagg ccagcggcta cacctttacc agctactaca tccactgggt gcgccaggcc 120 cctggacagg gactggaatg gatcggcagc atctaccccg gcaacgtgaa caccaactac 180 gcccagaagt tccagggcag agccaccctg accgtggaca ccagcatcag caccgcctac 240 atggaactga gccggctgag aagcgacgac accgccgtgt actactgcac ccggtcccac 300 tacggcctgg attggaactt cgacgtgtgg ggcaagggca ccaccgtgac agtgtctagc 360 agccaggtgc agctggtgga atctggcggc ggagtggtgc agcctggcag aagcctgaga 420 ctgagctgtg ccgccagcgg cttcaccttc accaaggcct ggatgcactg ggtgcgccag 480 gcccctggaa agcagctgga atgggtggcc cagatcaagg acaagagcaa cagctacgcc 540 acctactacg ccgacagcgt gaagggccgg ttcaccatca gccgggacga cagcaagaac 600 accctgtacc tgcagatgaa cagcctgcgg gccgaggaca ccgccgtgta ctactgtcgg 660 ggcgtgtact atgccctgag ccccttcgat tactggggcc agggaaccct cgtgaccgtg 720 tctagtcgga ccgccagcac aaagggccca tcggtgttcc ctctggcccc ttgcagcaga 780 agcaccagcg aatctacagc cgccctgggc tgcctcgtga aggactactt tcccgagccc 840 gtgaccgtgt cctggaactc tggcgctctg acaagcggcg tgcacacctt tccagccgtg 900 ctccagagca gcggcctgta ctctctgagc agcgtcgtga cagtgcccag cagcagcctg 960 ggcaccaaga cctacacctg taacgtggac cacaagccca gcaacaccaa ggtggacaag 1020 cgggtggaat ctaagtacgg ccctccctgc cctccttgcc cagcccctga agctgccggc 1080 ggaccctccg tgttcctgtt ccccccaaag cccaaggaca ccctgatgat cagccggacc 1140 cccgaagtga cctgcgtggt ggtggatgtg tcccaggaag atcccgaggt gcagttcaat 1200 tggtacgtgg acggcgtgga agtgcacaac gccaagacca agcccagaga ggaacagttc 1260 aacagcacct accgggtggt gtccgtgctg accgtgctgc accaggactg gctgaacggc 1320 aaagagtaca agtgcaaggt gtccaacaag ggcctgccca gctccatcga gaaaaccatc 1380 agcaaggcca agggccagcc ccgcgagcct caagtgtgta ccctgccccc tagccaggaa 1440 gagatgacca agaaccaggt gtccctgagc tgtgccgtga aaggcttcta ccccagcgac 1500 attgccgtgg aatgggagag caacggccag cccgagaaca actacaagac caccccccct 1560 gtgctggaca gcgacggctc attcttcctg gtgtccaagc tgaccgtgga caagagccgg 1620 tggcaggaag gcaacgtgtt cagctgctcc gtgatgcacg aggccctgca caaccactac 1680 acccagaagt ccctgtctct gtccctgggc 1710 <210> 73 <211> 1014 <212> ADN <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 73 gacatcgtga tgacccagac ccccctgagc ctgagcgtga cacctggaca gcctgccagc 60 atcagctgca agagcagcca gagcctggtg cacaacaacg ccaacaccta cctgagctgg 120 tatctgcaga agcccggcca gagcccccag tccctgatct acaaggtgtc caacagattc 180 agcggcgtgc ccgacagatt ctccggcagc ggctctggca ccgacttcac cctgaagatc 240 agccgggtgg aagccgagga cgtgggcgtg tactattgtg gccagggcac ccagtacccc 300 ttcacctttg gcagcggcac caaggtggaa atcaagggcc agcccaaggc cgcccccgac 360 atccagatga cccagagccc cagcagcctg tctgccagcg tgggcgacag agtgaccatc 420 acctgtcagg ccagccagaa catctacgtg tggctgaact ggtatcagca gaagcccggc 480 aaggccccca agctgctgat ctacaaggcc agcaacctgc acaccggcgt gcccagcaga 540 ttttctggca gcggctccgg caccgacttc accctgacaa tcagctccct gcagcccgag 600 gacattgcca cctactactg ccagcagggc cagacctacc cctacacctt tggccagggc 660 accaagctgg aaatcaagac caagggcccc agccgtacgg tggccgctcc cagcgtgttc 720 atcttcccac ctagcgacga gcagctgaag tccggcacag cctctgtcgt gtgcctgctg 780 aacaacttct acccccgcga ggccaaagtg cagtggaagg tggacaacgc cctgcagagc 840 ggcaacagcc aggaaagcgt gaccgagcag gacagcaagg actccaccta cagcctgagc 900 agcaccctga cactgagcaa ggccgactac gagaagcaca aggtgtacgc ctgcgaagtg 960 acccaccagg gcctgtctag ccccgtgacc aagagcttca accggggcga gtgt 1014 <210> 74 <211> 1338 <212> ADN <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 74 caggtgcagc tggtgcagtc tggcgccgaa gtcgtgaaac ctggcgcctc cgtgaaggtg 60 tcctgcaagg ccagcggcta cacctttacc agctacgcca tgcactgggt caaagaggcc 120 cctggccaga gactggaatg gatcggctac atctaccccg gccagggcgg caccaactac 180 aaccagaagt tccagggcag agccaccctg accgccgata caagcgccag caccgcctac 240 atggaactga gcagcctgcg gagcgaggat accgccgtgt acttctgtgc cagaacaggc 300 ggcctgaggc gggcctactt tacctattgg ggccagggca ccctcgtgac cgtgtctagc 360 gctagcacaa agggcccatc ggtgttccct ctggcccctt gcagcagaag caccagcgaa 420 tctacagccg ccctgggctg cctcgtgaag gactactttc ccgagcccgt gaccgtgtcc 480 tggaactctg gcgctctgac aagcggcgtg cacacctttc cagccgtgct ccagagcagc 540 ggcctgtact ctctgagcag cgtcgtgaca gtgcccagca gcagcctggg caccaagacc 600 tacacctgta acgtggacca caagcccagc aacaccaagg tggacaagcg ggtggaatct 660 aagtacggcc ctccctgccc tccttgccca gcccctgaag ctgccggcgg accctccgtg 720 ttcctgttcc ccccaaagcc caaggacacc ctgatgatca gccggacccc cgaagtgacc 780 tgcgtggtgg tggatgtgtc ccaggaagat cccgaggtgc agttcaattg gtacgtggac 840 ggcgtggaag tgcacaacgc caagaccaag cccagagagg aacagttcaa cagcacctac 900 cgggtggtgt ccgtgctgac cgtgctgcac caggactggc tgaacggcaa agagtacaag 960 tgcaaggtgt ccaacaaggg cctgcccagc tccatcgaga aaaccatcag caaggccaag 1020 ggccagcccc gcgagcctca agtgtatacc ctgccccctt gccaggaaga gatgaccaag 1080 aaccaggtgt ccctgtggtg tctcgtgaaa ggcttctacc ccagcgacat tgccgtggaa 1140 tgggagagca acggccagcc cgagaacaac tacaagacca ccccccctgt gctggacagc 1200 gacggctcat tcttcctgta ctccaagctg accgtggaca agagccggtg gcaggaaggc 1260 aacgtgttca gctgctccgt gatgcacgag gccctgcaca accactacac ccagaagtcc 1320 ctgtctctgt ccctgggc 1338 <210> 75 <211> 654 <212> ADN <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 75 gacatcgtgc tgacacagag ccctgccacc ctgtctctga gccctggcga gagagccacc 60 atcagctgta gagccagcca gagcgtgtcc agctacggcc agggcttcat gcactggtat 120 cagcagaagc ccggccagcc ccccagactg ctgatctatg gcgccagcag cagagccaca 180 ggcatccccg ccagattttc tggctctggc agcggcaccg acttcaccct gacaatcagc 240 cccctggaac ccgaggactt cgccgtgtac tactgccagc agaacaaaga ggacccctgg 300 accttcggcg gaggcaccaa gctggaaatc aagcgtacgg tggccgctcc cagcgtgttc 360 atcttcccac ctagcgacga gcagctgaag tccggcacag cctctgtcgt gtgcctgctg 420 aacaacttct acccccgcga ggccaaggtg cagtggaagg tggacaatgc cctgcagagc 480 ggcaacagcc aggaaagcgt gaccgagcag gacagcaagg actccaccta cagcctgagc 540 agcaccctga ccctgtccaa ggccgattac gagaagcaca aggtgtacgc ctgcgaagtg 600 acccaccagg gcctgtctag ccccgtgacc aagagcttca accggggcga gtgc 654 <210> 76 <211> 1719 <212> ADN <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 76 caggtgcagc tggtgcagtc tggcgccgag gtcgtgaaac ctggcgcctc tgtgaaggtg 60 tcctgcaagg ccagcggcta cacctttacc agctactaca tccactgggt gcgccaggcc 120 cctggacagg gactggaatg gatcggcagc atctaccccg gcaacgtgaa caccaactac 180 gcccagaagt tccagggcag agccaccctg accgtggaca ccagcatcag caccgcctac 240 atggaactga gccggctgag aagcgacgac accgccgtgt actactgcac ccggtcccac 300 tacggcctgg attggaactt cgacgtgtgg ggcaagggca ccaccgtgac agtgtctagc 360 agccaggtgc agctggtgga atctggcggc ggagtggtgc agcctggcag aagcctgaga 420 ctgagctgtg ccgccagcgg cttcaccttc accaaggcct ggatgcactg ggtgcgccag 480 gcccctggaa agcagctgga atgggtggcc cagatcaagg acaagagcaa cagctacgcc 540 acctactacg ccgacagcgt gaagggccgg ttcaccatca gccgggacga cagcaagaac 600 accctgtacc tgcagatgaa cagcctgcgg gccgaggaca ccgccgtgta ctactgtcgg 660 ggcgtgtact atgccctgag ccccttcgat tactggggcc agggaaccct cgtgaccgtg 720 tctagtcgga ccgccagcac aaagggcccc agcgtgttcc ctctggcccc tagcagcaag 780 agcacatctg gcggaacagc cgccctgggc tgcctcgtga aggactactt tcccgagccc 840 gtgaccgtgt cctggaattc tggcgccctg accagcggcg tgcacacctt tccagctgtg 900 ctgcagtcca gcggcctgta cagcctgagc agcgtcgtga cagtgcccag cagctctctg 960 ggcacccaga cctacatctg caacgtgaac cacaagccca gcaacaccaa ggtggacaag 1020 aaggtggaac ccaagagctg cgacaagacc cacacctgtc ccccttgtcc tgcccccgaa 1080 gccgccggag gcccttccgt gttcctgttc cccccaaagc ccaaggacac cctgatgatc 1140 agccggaccc ccgaagtgac ctgcgtggtg gtggatgtgt cccacgagga ccctgaagtg 1200 aagttcaatt ggtacgtgga cggcgtggaa gtgcacaacg ccaagaccaa gccaagagag 1260 gaacagtaca acagcaccta ccgggtggtg tccgtgctga ccgtgctgca ccaggactgg 1320 ctgaacggca aagagtacaa gtgcaaggtg tccaacaagg ccctggccgc ccccatcgag 1380 aaaaccatca gcaaggccaa gggccagccc cgcgaacccc aggtgtgcac actgccccca 1440 agcagggacg agctgaccaa gaaccaggtg tccctgagct gtgccgtgaa aggcttctac 1500 ccctccgata tcgccgtgga atgggagagc aacggccagc ccgagaacaa ctacaagacc 1560 accccccctg tgctggacag cgacggctca ttcttcctgg tgtccaagct gacagtggac 1620 aagtcccggt ggcagcaggg caacgtgttc agctgctccg tgatgcacga ggccctgcac 1680 aaccactaca cccagaagtc cctgagcctg agccccggc 1719 <210> 77 <211> 1347 <212> ADN <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 77 caggtgcagc tggtgcagtc tggcgccgaa gtcgtgaaac ctggcgcctc cgtgaaggtg 60 tcctgcaagg ccagcggcta cacctttacc agctacgcca tgcactgggt caaagaggcc 120 cctggccaga gactggaatg gatcggctac atctaccccg gccagggcgg caccaactac 180 aaccagaagt tccagggcag agccaccctg accgccgata caagcgccag caccgcctac 240 atggaactga gcagcctgcg gagcgaggat accgccgtgt acttctgtgc cagaacaggc 300 ggcctgaggc gggcctactt tacctattgg ggccagggca ccctcgtgac cgtgtctagc 360 gctagcacaa agggccccag cgtgttccct ctggccccta gcagcaagag cacatctggc 420 ggaacagccg ccctgggctg cctcgtgaag gactactttc ccgagcccgt gaccgtgtcc 480 tggaattctg gcgccctgac cagcggcgtg cacacctttc cagctgtgct gcagtccagc 540 ggcctgtaca gcctgagcag cgtcgtgaca gtgcccagca gctctctggg cacccagacc 600 tacatctgca acgtgaacca caagcccagc aacaccaagg tggacaagaa ggtggaaccc 660 aagagctgcg acaagaccca cacctgtccc ccttgtcctg cccccgaagc cgccggaggc 720 ccttccgtgt tcctgttccc cccaaagccc aaggacaccc tgatgatcag ccggaccccc 780 gaagtgacct gcgtggtggt ggatgtgtcc cacgaggacc ctgaagtgaa gttcaattgg 840 tacgtggacg gcgtggaagt gcacaacgcc aagaccaagc caagagagga acagtacaac 900 agcacctacc gggtggtgtc cgtgctgacc gtgctgcacc aggactggct gaacggcaaa 960 gagtacaagt gcaaggtgtc caacaaggcc ctggccgccc ccatcgagaa aaccatcagc 1020 aaggccaagg gccagccccg cgaaccccag gtgtacacac tgcccccatg cagggacgag 1080 ctgaccaaga accaggtgtc cctgtggtgt ctggtgaaag gcttctaccc ctccgatatc 1140 gccgtggaat gggagagcaa cggccagccc gagaacaact acaagaccac cccccctgtg 1200 ctggacagcg acggctcatt cttcctgtac tccaagctga cagtggacaa gtcccggtgg 1260 cagcagggca acgtgttcag ctgctccgtg atgcacgagg ccctgcacaa ccactacacc 1320 cagaagtccc tgagcctgag ccccggc 1347 <210> 78 <211> 1719 <212> ADN <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 78 caggtgcagc tggtgcagtc tggcgccgag gtcgtgaaac ctggcgcctc tgtgaaggtg 60 tcctgcaagg ccagcggcta cacctttacc agctactaca tccactgggt gcgccaggcc 120 cctggacagg gactggaatg gatcggcagc atctaccccg gcaacgtgaa caccaactac 180 gcccagaagt tccagggcag agccaccctg accgtggaca ccagcatcag caccgcctac 240 atggaactga gccggctgag aagcgacgac accgccgtgt actactgcac ccggtcccac 300 tacggcctgg attggaactt cgacgtgtgg ggcaagggca ccaccgtgac agtgtctagc 360 agccaggtgc agctggtgga atctggcggc ggagtggtgc agcctggcag aagcctgaga 420 ctgagctgtg ccgccagcgg cttcaccttc accaaggcct ggatgcactg ggtgcgccag 480 gcccctggaa agcagctgga atgggtggcc cagatcaagg acaagagcaa cagctacgcc 540 acctactacg ccgacagcgt gaagggccgg ttcaccatca gccgggacga cagcaagaac 600 accctgtacc tgcagatgaa cagcctgcgg gccgaggaca ccgccgtgta ctactgtcgg 660 ggcgtgtact atgccctgag ccccttcgat tactggggcc agggaaccct cgtgaccgtg 720 tctagtcgga ccgccagcac aaagggcccc agcgtgttcc ctctggcccc tagcagcaag 780 agcacatctg gcggaacagc cgccctgggc tgcctcgtga aggactactt tcccgagccc 840 gtgaccgtgt cctggaattc tggcgccctg accagcggcg tgcacacctt tccagctgtg 900 ctgcagtcca gcggcctgta cagcctgagc agcgtcgtga cagtgcccag cagctctctg 960 ggcacccaga cctacatctg caacgtgaac cacaagccca gcaacaccaa ggtggacaag 1020 aaggtggaac ccaagagctg cgacaagacc cacacctgtc ccccttgtcc tgcccccgaa 1080 ctgctgggag gcccttccgt gttcctgttc cccccaaagc ccaaggacac cctgatgatc 1140 agccggaccc ccgaagtgac ctgcgtggtg gtggatgtgt cccacgagga ccctgaagtg 1200 aagttcaatt ggtacgtgga cggcgtggaa gtgcacaacg ccaagaccaa gccaagagag 1260 gaacagtaca acaatgcctc ccgggtggtg tccgtgctga ccgtgctgca ccaggactgg 1320 ctgaacggca aagagtacaa gtgcaaggtg tccaacaagg ccctgcctgc ccccatcgag 1380 aaaaccatca gcaaggccaa gggccagccc cgcgaacccc aggtgtgcac actgccccca 1440 agcagggacg agctgaccaa gaaccaggtg tccctgagct gtgccgtgaa aggcttctac 1500 ccctccgata tcgccgtgga atgggagagc aacggccagc ccgagaacaa ctacaagacc 1560 accccccctg tgctggacag cgacggctca ttcttcctgg tgtccaagct gacagtggac 1620 aagtcccggt ggcagcaggg caacgtgttc agctgctccg tgatgcacga ggccctgcac 1680 aaccactaca cccagaagtc cctgagcctg agccccggc 1719 <210> 79 <211> 1347 <212> ADN <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 79 caggtgcagc tggtgcagtc tggcgccgaa gtcgtgaaac ctggcgcctc cgtgaaggtg 60 tcctgcaagg ccagcggcta cacctttacc agctacgcca tgcactgggt caaagaggcc 120 cctggccaga gactggaatg gatcggctac atctaccccg gccagggcgg caccaactac 180 aaccagaagt tccagggcag agccaccctg accgccgata caagcgccag caccgcctac 240 atggaactga gcagcctgcg gagcgaggat accgccgtgt acttctgtgc cagaacaggc 300 ggcctgaggc gggcctactt tacctattgg ggccagggca ccctcgtgac cgtgtctagc 360 gctagcacaa agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg 420 ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg 480 tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca 540 ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc 600 tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc 660 aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga 720 ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct 780 gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg 840 tatgttgacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac 900 aatgcctccc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag 960 gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc 1020 aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatg ccgggatgag 1080 ctgaccaaga atcaagtcag cctgtggtgc ctggtaaaag gcttctatcc cagcgacatc 1140 gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg 1200 ctggactccg acggctcctt cttcctctac tcaaaactca ccgtggacaa gagcaggtgg 1260 cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg 1320 cagaagagcc tctccctgtc tccgggt 1347 <210> 80 <211> 1329 <212> ADN <213> Secuenca Artificial <220> <223> Construcción Sintética <400> 80 caggtgcagc tggtggaaag cggcggaggc gtggtgcagc ctggcaggtc tctgagactg 60 agctgtgccg ccagcggctt caccttcagc agctacggaa tgcactgggt gcgccaggcc 120 cctggcaaag gactggaatg ggtggccgtg atttggtacg acggcagcaa caagtactac 180 gccgacagcg tgaagggccg gttcaccatc agcggcgaca acagcaagaa caccctgtac 240 ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgcgc cagaatgttc 300 agaggcgcct tcgactactg gggccagggc acactcgtga ccgtgtctag tgcgtcgacc 360 aagggcccat cggtgttccc tctggcccct tgcagcagaa gcaccagcga atctacagcc 420 gccctgggct gcctcgtgaa ggactacttt cccgagcccg tgaccgtgtc ctggaactct 480 ggcgctctga caagcggcgt gcacaccttt ccagccgtgc tccagagcag cggcctgtac 540 tctctgagca gcgtcgtgac agtgcccagc agcagcctgg gcaccaagac ctacacctgt 600 aacgtggacc acaagcccag caacaccaag gtggacaagc gggtggaatc taagtacggc 660 cctccctgcc ctccttgccc agcccctgaa gctgccggcg gaccctccgt gttcctgttc 720 cccccaaagc ccaaggacac cctgatgatc agccggaccc ccgaagtgac ctgcgtggtg 780 gtggatgtgt cccaggaaga tcccgaggtg cagttcaatt ggtacgtgga cggcgtggaa 840 gtgcacaacg ccaagaccaa gcccagagag gaacagttca acagcaccta ccgggtggtg 900 tccgtgctga ccgtgctgca ccaggactgg ctgaacggca aagagtacaa gtgcaaggtg 960 tccaacaagg gcctgcccag ctccatcgag aaaaccatca gcaaggccaa gggccagccc 1020 cgcgagcctc aagtgtatac cctgccccct tgccaggaag agatgaccaa gaaccaggtg 1080 tccctgtggt gtctcgtgaa aggcttctac cccagcgaca ttgccgtgga atgggagagc 1140 aacggccagc ccgagaacaa ctacaagacc accccccctg tgctggacag cgacggctca 1200 ttcttcctgt actccaagct gaccgtggac aagagccggt ggcaggaagg caacgtgttc 1260 agctgctccg tgatgcacga ggccctgcac aaccactaca cccagaagtc cctgtctctg 1320 tccctgggc 1329 <210> 81 <211> 642 <212> ADN <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 81 gccatccaga tgacccagag ccccagcagc ctgtctgcca gcgtgggcga cagagtgacc 60 atcacctgta gagccagcca gggcatccgg aacgacctgg gctggtatca gcagaagcct 120 ggcaaggccc ccaagctgct gatctacgcc gctagctctc tgcagtccgg cgtgcccagc 180 agattttctg gcagcggctc cggcaccgac ttcaccctga caatctctgg cctgcagccc 240 gaggacagcg ccacctacta ctgtctgcaa gactacatct actaccccac cttcggccag 300 ggcaccaagg tggaaatcaa gcgtacggtg gccgctccca gcgtgttcat cttcccacct 360 agcgacgagc agctgaagtc cggcacagcc tctgtcgtgt gcctgctgaa caacttctac 420 ccccgcgagg ccaaagtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag 480 gaaagcgtga ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgaca 540 ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc 600 ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gt 642 <210> 82 <211> 1338 <212> ADN <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 82 caggtgcagc tggtggaaag cggcggaggc gtggtgcagc ctggcaggtc tctgagactg 60 agctgtgccg ccagcggctt caccttcagc agctacggaa tgcactgggt gcgccaggcc 120 cctggcaaag gactggaatg ggtggccgtg atttggtacg acggcagcaa caagtactac 180 gccgacagcg tgaagggccg gttcaccatc agcggcgaca acagcaagaa caccctgtac 240 ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgcgc cagaatgttc 300 agaggcgcct tcgactactg gggccagggc acactcgtga ccgtgtctag tgcgtcgacc 360 aagggcccca gcgtgttccc tctggcccct agcagcaaga gcacatctgg cggaacagcc 420 gccctgggct gcctcgtgaa ggactacttt cccgagcccg tgaccgtgtc ctggaattct 480 ggcgccctga ccagcggcgt gcacaccttt ccagctgtgc tgcagtccag cggcctgtac 540 agcctgagca gcgtcgtgac agtgcccagc agctctctgg gcacccagac ctacatctgc 600 aacgtgaacc acaagcccag caacaccaag gtggacaaga aggtggaacc caagagctgc 660 gacaagaccc acacctgtcc cccttgtcct gcccccgaag ccgccggagg cccttccgtg 720 ttcctgttcc ccccaaagcc caaggacacc ctgatgatca gccggacccc cgaagtgacc 780 tgcgtggtgg tggatgtgtc ccacgaggac cctgaagtga agttcaattg gtacgtggac 840 ggcgtggaag tgcacaacgc caagaccaag ccaagagagg aacagtacaa cagcacctac 900 cgggtggtgt ccgtgctgac cgtgctgcac caggactggc tgaacggcaa agagtacaag 960 tgcaaggtgt ccaacaaggc cctggccgcc cccatcgaga aaaccatcag caaggccaag 1020 ggccagcccc gcgaacccca ggtgtacaca ctgcccccat gcagggacga gctgaccaag 1080 aaccaggtgt ccctgtggtg tctggtgaaa ggcttctacc cctccgatat cgccgtggaa 1140 tgggagagca acggccagcc cgagaacaac tacaagacca ccccccctgt gctggacagc 1200 gacggctcat tcttcctgta ctccaagctg acagtggaca agtcccggtg gcagcagggc 1260 aacgtgttca gctgctccgt gatgcacgag gccctgcaca accactacac ccagaagtcc 1320 ctgagcctga gccccggc 1338 <210> 83 <211> 1338 <212> ADN <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 83 caggtgcagc tggtggaaag cggcggaggc gtggtgcagc ctggcaggtc tctgagactg 60 agctgtgccg ccagcggctt caccttcagc agctacggaa tgcactgggt gcgccaggcc 120 cctggcaaag gactggaatg ggtggccgtg atttggtacg acggcagcaa caagtactac 180 gccgacagcg tgaagggccg gttcaccatc agcggcgaca acagcaagaa caccctgtac 240 ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgcgc cagaatgttc 300 agaggcgcct tcgactactg gggccagggc acactcgtga ccgtgtctag tgcgtcgacc 360 aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg 420 gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca 480 ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac 540 tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc 600 aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt 660 gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc 720 ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca 780 tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtatgttgac 840 ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa caatgcctcc 900 cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag 960 tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa 1020 gggcagcccc gagaaccaca ggtgtacacc ctgcccccat gccgggatga gctgaccaag 1080 aatcaagtca gcctgtggtg cctggtaaaa ggcttctatc ccagcgacat cgccgtggag 1140 tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc 1200 gacggctcct tcttcctcta ctcaaaactc accgtggaca agagcaggtg gcagcagggg 1260 aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc 1320 ctctccctgt ctccgggt 1338 <210> 84 <211> 121 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 84 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Lys Ala 20 25 30 Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Gln Ile Lys Asp Lys Ser Asn Ser Tyr Ala Thr Tyr Tyr Ala Asp 50 55 60 Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Arg Gly Val Tyr Tyr Ala Leu Ser Pro Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 85 <211> 112 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 85 Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 1 5 10 15 Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Val His Asn 20 25 30 Asn Gly Asn Thr Tyr Leu Ser Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gly Gln Gly 85 90 95 Thr Gln Tyr Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 86 <211> 25 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 86 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser 20 25 <210> 87 <211> 25 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 87 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Ser Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser 20 25 <210> 88 <211> 25 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 88 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Met Ser Cys Lys Ala Ser 20 25 <210> 89 <211> 25 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 89 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser 20 25 <210> 90 <211> 17 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 90 Met His Trp Val Lys Glu Ala Pro Gly Gln Arg Leu Glu Trp Ile Gly 1 5 10 15 Tyr <210> 91 <211> 17 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 91 Met His Trp Val Lys Glu Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly 1 5 10 15 Tyr <210> 92 <211> 17 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 92 Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 1 5 10 15 Val <210> 93 <211> 38 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 93 Asn Tyr Asn Gln Lys Phe Gln Gly Arg Ala Thr Leu Thr Ala Asp Thr 1 5 10 15 Ser Ala Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 20 25 30 Thr Ala Val Tyr Phe Cys 35 <210> 94 <211> 38 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 94 Asn Tyr Asn Gln Lys Phe Gln Gly Arg Ala Thr Leu Thr Ala Asp Thr 1 5 10 15 Ser Ala Ser Thr Ala Tyr Met Glu Ile Ser Ser Leu Arg Ser Glu Asp 20 25 30 Thr Ala Val Tyr Phe Cys 35 <210> 95 <211> 38 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 95 Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gly Asp Asn 1 5 10 15 Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 20 25 30 Thr Ala Val Tyr Tyr Cys 35 <210> 96 <211> 11 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 96 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 1 5 10 <210> 97 <211> 26 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 97 Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser 20 25 <210> 98 <211> 26 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 98 Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 20 25 <210> 99 <211> 17 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 99 Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Arg Leu Leu Ile 1 5 10 15 Tyr <210> 100 <211> 16 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 100 Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 1 5 10 15 <210> 101 <211> 36 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 101 Ser Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 1 5 10 15 Thr Asp Phe Thr Leu Thr Ile Ser Pro Leu Glu Pro Glu Asp Phe Ala 20 25 30 Val Tyr Tyr Cys 35 <210> 102 <211> 36 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 102 Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 1 5 10 15 Thr Asp Phe Thr Leu Thr Ile Ser Gly Leu Gln Pro Glu Asp Ser Ala 20 25 30 Thr Tyr Tyr Cys 35 <210> 103 <211> 10 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 103 Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 1 5 10 <210> 104 <211> 11 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 104 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 1 5 10 <210> 105 <211> 159 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 105 Arg Trp Arg Gln Gln Trp Ser Gly Pro Gly Thr Thr Lys Arg Phe Pro 1 5 10 15 Glu Thr Val Leu Ala Arg Cys Val Lys Tyr Thr Glu Ile His Pro Glu 20 25 30 Met Arg His Val Asp Cys Gln Ser Val Trp Asp Ala Phe Lys Gly Ala 35 40 45 Phe Ile Ser Lys His Pro Cys Asn Ile Thr Glu Glu Asp Tyr Gln Pro 50 55 60 Leu Met Lys Leu Gly Thr Gln Thr Val Pro Cys Asn Lys Ile Leu Leu 65 70 75 80 Trp Ser Arg Ile Lys Asp Leu Ala His Gln Phe Thr Gln Val Gln Arg 85 90 95 Asp Met Phe Thr Leu Glu Asp Thr Leu Leu Gly Tyr Leu Ala Asp Asp 100 105 110 Leu Thr Trp Cys Gly Glu Phe Asn Thr Ser Lys Ile Asn Tyr Gln Ser 115 120 125 Cys Pro Asp Trp Arg Lys Asp Cys Ser Asn Asn Pro Val Ser Val Phe 130 135 140 Trp Lys Thr Val Ser Arg Arg His Phe Trp Glu Cys Gly Ser Pro 145 150 155 <210> 106 <211> 214 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 106 Asp Ile Val Met Thr Gln Ser His Leu Ser Met Ser Thr Ser Leu Gly 1 5 10 15 Asp Pro Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Val 20 25 30 Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Arg Arg Leu Ile 35 40 45 Tyr Ser Ala Ser Tyr Arg Tyr Ile Gly Val Pro Asp Arg Phe Thr Gly 50 55 60 Ser Gly Ala Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala 65 70 75 80 Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Pro Pro Tyr 85 90 95 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 100 105 110 Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 115 120 125 Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 130 135 140 Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 145 150 155 160 Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 165 170 175 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 180 185 190 Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 195 200 205 Phe Asn Arg Gly Glu Cys 210 <210> 107 <211> 450 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 107 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Ala Lys Pro Gly Thr 1 5 10 15 Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 20 25 30 Trp Met Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Thr Ile Tyr Pro Gly Asp Gly Asp Thr Gly Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Lys Thr Val Tyr 65 70 75 80 Met His Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Asn Ser Leu Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 115 120 125 Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 130 135 140 Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 145 150 155 160 Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 165 170 175 Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 180 185 190 Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 195 200 205 Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 210 215 220 Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 225 230 235 240 Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 245 250 255 Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 260 265 270 Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 275 280 285 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 290 295 300 Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 305 310 315 320 Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 325 330 335 Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 340 345 350 Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 355 360 365 Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 370 375 380 Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 385 390 395 400 Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 405 410 415 Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 420 425 430 Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 435 440 445 Gly Lys 450 <210> 108 <211> 8 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 108 Gly Tyr Thr Phe Thr Ser Tyr Tyr 1 5 <210> 109 <211> 8 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 109 Ile Tyr Pro Gly Asn Val Asn Thr 1 5 <210> 110 <211> 13 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 110 Thr Arg Ser His Tyr Gly Leu Asp Trp Asn Phe Asp Val 1 5 10 <210> 111 <211> 6 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 111 Gln Asn Ile Tyr Val Trp 1 5 <210> 112 <211> 3 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 112 Lys Ala Ser 1 <210> 113 <211> 8 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 113 Gln Gln Gly Gln Thr Tyr Pro Tyr 1 5 <210> 114 <211> 8 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 114 Gly Phe Ser Leu Ser Asp Tyr Gly 1 5 <210> 115 <211> 7 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 115 Ile Trp Ala Gly Gly Gly Thr 1 5 <210> 116 <211> 14 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 116 Ala Arg Asp Lys Gly Tyr Ser Tyr Tyr Tyr Ser Met Asp Tyr 1 5 10 <210> 117 <211> 10 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 117 Glu Ser Val Glu Tyr Tyr Val Thr Ser Leu 1 5 10 <210> 118 <211> 3 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 118 Ala Ala Ser 1 <210> 119 <211> 9 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 119 Gln Gln Ser Arg Lys Val Pro Tyr Thr 1 5 <210> 120 <211> 8 <212> PRT <213> Seecuencia Artificial <220> <223> Construcción Sintética <400> 120 Gly Phe Thr Phe Thr Lys Ala Trp 1 5 <210> 121 <211> 10 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 121 Ile Lys Asp Lys Ser Asn Ser Tyr Ala Thr 1 5 10 <210> 122 <211> 12 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 122 Arg Gly Val Tyr Tyr Ala Leu Ser Pro Phe Asp Tyr 1 5 10 <210> 123 <211> 11 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 123 Gln Ser Leu Val His Asn Asn Ala Asn Thr Tyr 1 5 10 <210> 124 <211> 3 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 124 Lys Val Ser 1 <210> 125 <211> 9 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 125 Gly Gln Gly Thr Gln Tyr Pro Phe Thr 1 5 <210> 126 <211> 8 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 126 Gly Phe Thr Phe Thr Lys Ala Trp 1 5 <210> 127 <211> 10 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 127 Ile Lys Asp Lys Ser Asn Ser Tyr Ala Thr 1 5 10 <210> 128 <211> 11 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 128 Gly Val Tyr Tyr Ala Leu Ser Pro Phe Asp Tyr 1 5 10 <210> 129 <211> 11 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 129 Gln Ser Leu Val His Asn Asn Gly Asn Thr Tyr 1 5 10 <210> 130 <211> 3 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 130 Lys Val Ser 1 <210> 131 <211> 9 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 131 Gly Gln Gly Thr Gln Tyr Pro Phe Thr 1 5 <210> 132 <211> 9 <212> PRT <213> Secuencia Artificial <220> <223> Construcción Sintética <400> 132 Gln Ser Val Ser Ser Tyr Gly Gln Gly 1 5