LISTADO DE SECUENCIAS <110> AFFINIVAX, INC. <120> VACUNAS NEUMOCÓCICAS MULTIVALENTES <130> 2011588-0068 <140> PCT/US2019/050907 <141> 2019-09-12 <150> 62/730,471 <151> 2018-09-12 <160> 14 <170> PatentIn versión 3.5 <210> 1 <211> 179 <212> PRT <213> Desconocido <220> <223> Descripción de desconocido: Secuencia de proteína de rizavidina <400> 1 Met Ile Ile Thr Ser Leu Tyr Ala Thr Phe Gly Thr Ile Ala Asp Gly 1 5 10 15 Arg Arg Thr Ser Gly Gly Lys Thr Met Ile Arg Thr Asn Ala Val Ala 20 25 30 Ala Leu Val Phe Ala Val Ala Thr Ser Ala Leu Ala Phe Asp Ala Ser 35 40 45 Asn Phe Lys Asp Phe Ser Ser Ile Ala Ser Ala Ser Ser Ser Trp Gln 50 55 60 Asn Gln Ser Gly Ser Thr Met Ile Ile Gln Val Asp Ser Phe Gly Asn 65 70 75 80 Val Ser Gly Gln Tyr Val Asn Arg Ala Gln Gly Thr Gly Cys Gln Asn 85 90 95 Ser Pro Tyr Pro Leu Thr Gly Arg Val Asn Gly Thr Phe Ile Ala Phe 100 105 110 Ser Val Gly Trp Asn Asn Ser Thr Glu Asn Cys Asn Ser Ala Thr Gly 115 120 125 Trp Thr Gly Tyr Ala Gln Val Asn Gly Asn Asn Thr Glu Ile Val Thr 130 135 140 Ser Trp Asn Leu Ala Tyr Glu Gly Gly Ser Gly Pro Ala Ile Glu Gln 145 150 155 160 Gly Gln Asp Thr Phe Gln Tyr Val Pro Thr Thr Glu Asn Lys Ser Leu 165 170 175 Leu Lys Asp <210> 2 <211> 135 <212> PRT <213> Desconocido <220> <223> Descripción de desconocido: Secuencia de proteína de rizavidina <400> 2 Phe Asp Ala Ser Asn Phe Lys Asp Phe Ser Ser Ile Ala Ser Ala Ser 1 5 10 15 Ser Ser Trp Gln Asn Gln Ser Gly Ser Thr Met Ile Ile Gln Val Asp 20 25 30 Ser Phe Gly Asn Val Ser Gly Gln Tyr Val Asn Arg Ala Gln Gly Thr 35 40 45 Gly Cys Gln Asn Ser Pro Tyr Pro Leu Thr Gly Arg Val Asn Gly Thr 50 55 60 Phe Ile Ala Phe Ser Val Gly Trp Asn Asn Ser Thr Glu Asn Cys Asn 65 70 75 80 Ser Ala Thr Gly Trp Thr Gly Tyr Ala Gln Val Asn Gly Asn Asn Thr 85 90 95 Glu Ile Val Thr Ser Trp Asn Leu Ala Tyr Glu Gly Gly Ser Gly Pro 100 105 110 Ala Ile Glu Gln Gly Gln Asp Thr Phe Gln Tyr Val Pro Thr Thr Glu 115 120 125 Asn Lys Ser Leu Leu Lys Asp 130 135 <210> 3 <211> 7 <212> PRT <213> Secuencia artificial <220> <223> Descripción de secuencia artificial: Péptido sintético <400> 3 Gly Gly Gly Gly Ser Ser Ser 1 5 <210> 4 <211> 367 <212> PRT <213> Streptococcus pneumoniae <400> 4 Phe Arg Gln Pro Ser Gln Thr Ala Leu Lys Asp Glu Pro Thr His Leu 1 5 10 15 Val Val Ala Lys Glu Gly Ser Val Ala Ser Ser Val Leu Leu Ser Gly 20 25 30 Thr Val Thr Ala Lys Asn Glu Gln Tyr Val Tyr Phe Asp Ala Ser Lys 35 40 45 Gly Asp Leu Asp Glu Ile Leu Val Ser Val Gly Asp Lys Val Ser Glu 50 55 60 Gly Gln Ala Leu Val Lys Tyr Ser Ser Ser Glu Ala Gln Ala Ala Tyr 65 70 75 80 Asp Ser Ala Ser Arg Ala Val Ala Arg Ala Asp Arg His Ile Asn Glu 85 90 95 Leu Asn Gln Ala Arg Asn Glu Ala Ala Ser Ala Pro Ala Pro Gln Leu 100 105 110 Pro Ala Pro Val Gly Gly Glu Asp Ala Thr Val Gln Ser Pro Thr Pro 115 120 125 Val Ala Gly Asn Ser Val Ala Ser Ile Asp Ala Gln Leu Gly Asp Ala 130 135 140 Arg Asp Ala Arg Ala Asp Ala Ala Ala Gln Leu Ser Lys Ala Gln Ser 145 150 155 160 Gln Leu Asp Ala Thr Thr Val Leu Ser Thr Leu Glu Gly Thr Val Val 165 170 175 Glu Val Asn Ser Asn Val Ser Lys Ser Pro Thr Gly Ala Ser Gln Val 180 185 190 Met Val His Ile Val Ser Asn Glu Asn Leu Gln Val Lys Gly Glu Leu 195 200 205 Ser Glu Tyr Asn Leu Ala Asn Leu Ser Val Gly Gln Glu Val Ser Phe 210 215 220 Thr Ser Lys Val Tyr Pro Asp Lys Lys Trp Thr Gly Lys Leu Ser Tyr 225 230 235 240 Ile Ser Asp Tyr Pro Lys Asn Asn Gly Glu Ala Ala Ser Pro Ala Ala 245 250 255 Gly Asn Asn Thr Gly Ser Lys Tyr Pro Tyr Thr Ile Asp Val Thr Gly 260 265 270 Glu Val Gly Asp Leu Lys Gln Gly Phe Ser Val Asn Ile Glu Val Lys 275 280 285 Ser Lys Thr Lys Ala Ile Leu Val Pro Val Ser Ser Leu Val Met Asp 290 295 300 Asp Ser Lys Asn Tyr Val Trp Ile Val Asp Glu Gln Gln Lys Ala Lys 305 310 315 320 Lys Val Glu Val Ser Leu Gly Asn Ala Asp Ala Glu Asn Gln Glu Ile 325 330 335 Thr Ser Gly Leu Thr Asn Gly Ala Lys Val Ile Ser Asn Pro Thr Ser 340 345 350 Ser Leu Glu Glu Gly Lys Glu Val Lys Ala Asp Glu Ala Thr Asn 355 360 365 <210> 5 <211> 252 <212> PRT <213> Streptococcus pneumoniae <400> 5 Thr Ser Gly Asp Asn Trp Ser Lys Tyr Gln Ser Asn Lys Ser Ile Thr 1 5 10 15 Ile Gly Phe Asp Ser Thr Phe Val Pro Met Gly Phe Ala Gln Lys Asp 20 25 30 Gly Ser Tyr Ala Gly Phe Asp Ile Asp Leu Ala Thr Ala Val Phe Glu 35 40 45 Lys Tyr Gly Ile Thr Val Asn Trp Gln Pro Ile Asp Trp Asp Leu Lys 50 55 60 Glu Ala Glu Leu Thr Lys Gly Thr Ile Asp Leu Ile Trp Asn Gly Tyr 65 70 75 80 Ser Ala Thr Asp Glu Arg Arg Glu Lys Val Ala Phe Ser Asn Ser Tyr 85 90 95 Met Lys Asn Glu Gln Val Leu Val Thr Lys Lys Ser Ser Gly Ile Thr 100 105 110 Thr Ala Lys Asp Met Thr Gly Lys Thr Leu Gly Ala Gln Ala Gly Ser 115 120 125 Ser Gly Tyr Ala Asp Phe Glu Ala Asn Pro Glu Ile Leu Lys Asn Ile 130 135 140 Val Ala Asn Lys Glu Ala Asn Gln Tyr Gln Thr Phe Asn Glu Ala Leu 145 150 155 160 Ile Asp Leu Lys Asn Asp Arg Ile Asp Gly Leu Leu Ile Asp Arg Val 165 170 175 Tyr Ala Asn Tyr Tyr Leu Glu Ala Glu Gly Val Leu Asn Asp Tyr Asn 180 185 190 Val Phe Thr Val Gly Leu Glu Thr Glu Ala Phe Ala Val Gly Ala Arg 195 200 205 Lys Glu Asp Thr Asn Leu Val Lys Lys Ile Asn Glu Ala Phe Ser Ser 210 215 220 Leu Tyr Lys Asp Gly Lys Phe Gln Glu Ile Ser Gln Lys Trp Phe Gly 225 230 235 240 Glu Asp Val Ala Thr Lys Glu Val Lys Glu Gly Gln 245 250 <210> 6 <211> 765 <212> PRT <213> Secuencia artificial <220> <223> Descripción de secuencia artificial: Polipéptido sintético <400> 6 Met Phe Asp Ala Ser Asn Phe Lys Asp Phe Ser Ser Ile Ala Ser Ala 1 5 10 15 Ser Ser Ser Trp Gln Asn Gln Ser Gly Ser Thr Met Ile Ile Gln Val 20 25 30 Asp Ser Phe Gly Asn Val Ser Gly Gln Tyr Val Asn Arg Ala Gln Gly 35 40 45 Thr Gly Cys Gln Asn Ser Pro Tyr Pro Leu Thr Gly Arg Val Asn Gly 50 55 60 Thr Phe Ile Ala Phe Ser Val Gly Trp Asn Asn Ser Thr Glu Asn Cys 65 70 75 80 Asn Ser Ala Thr Gly Trp Thr Gly Tyr Ala Gln Val Asn Gly Asn Asn 85 90 95 Thr Glu Ile Val Thr Ser Trp Asn Leu Ala Tyr Glu Gly Gly Ser Gly 100 105 110 Pro Ala Ile Glu Gln Gly Gln Asp Thr Phe Gln Tyr Val Pro Thr Thr 115 120 125 Glu Asn Lys Ser Leu Leu Lys Asp Gly Gly Gly Gly Ser Ser Ser Thr 130 135 140 Ser Gly Asp Asn Trp Ser Lys Tyr Gln Ser Asn Lys Ser Ile Thr Ile 145 150 155 160 Gly Phe Asp Ser Thr Phe Val Pro Met Gly Phe Ala Gln Lys Asp Gly 165 170 175 Ser Tyr Ala Gly Phe Asp Ile Asp Leu Ala Thr Ala Val Phe Glu Lys 180 185 190 Tyr Gly Ile Thr Val Asn Trp Gln Pro Ile Asp Trp Asp Leu Lys Glu 195 200 205 Ala Glu Leu Thr Lys Gly Thr Ile Asp Leu Ile Trp Asn Gly Tyr Ser 210 215 220 Ala Thr Asp Glu Arg Arg Glu Lys Val Ala Phe Ser Asn Ser Tyr Met 225 230 235 240 Lys Asn Glu Gln Val Leu Val Thr Lys Lys Ser Ser Gly Ile Thr Thr 245 250 255 Ala Lys Asp Met Thr Gly Lys Thr Leu Gly Ala Gln Ala Gly Ser Ser 260 265 270 Gly Tyr Ala Asp Phe Glu Ala Asn Pro Glu Ile Leu Lys Asn Ile Val 275 280 285 Ala Asn Lys Glu Ala Asn Gln Tyr Gln Thr Phe Asn Glu Ala Leu Ile 290 295 300 Asp Leu Lys Asn Asp Arg Ile Asp Gly Leu Leu Ile Asp Arg Val Tyr 305 310 315 320 Ala Asn Tyr Tyr Leu Glu Ala Glu Gly Val Leu Asn Asp Tyr Asn Val 325 330 335 Phe Thr Val Gly Leu Glu Thr Glu Ala Phe Ala Val Gly Ala Arg Lys 340 345 350 Glu Asp Thr Asn Leu Val Lys Lys Ile Asn Glu Ala Phe Ser Ser Leu 355 360 365 Tyr Lys Asp Gly Lys Phe Gln Glu Ile Ser Gln Lys Trp Phe Gly Glu 370 375 380 Asp Val Ala Thr Lys Glu Val Lys Glu Gly Gln Ala Ala Ala Phe Arg 385 390 395 400 Gln Pro Ser Gln Thr Ala Leu Lys Asp Glu Pro Thr His Leu Val Val 405 410 415 Ala Lys Glu Gly Ser Val Ala Ser Ser Val Leu Leu Ser Gly Thr Val 420 425 430 Thr Ala Lys Asn Glu Gln Tyr Val Tyr Phe Asp Ala Ser Lys Gly Asp 435 440 445 Leu Asp Glu Ile Leu Val Ser Val Gly Asp Lys Val Ser Glu Gly Gln 450 455 460 Ala Leu Val Lys Tyr Ser Ser Ser Glu Ala Gln Ala Ala Tyr Asp Ser 465 470 475 480 Ala Ser Arg Ala Val Ala Arg Ala Asp Arg His Ile Asn Glu Leu Asn 485 490 495 Gln Ala Arg Asn Glu Ala Ala Ser Ala Pro Ala Pro Gln Leu Pro Ala 500 505 510 Pro Val Gly Gly Glu Asp Ala Thr Val Gln Ser Pro Thr Pro Val Ala 515 520 525 Gly Asn Ser Val Ala Ser Ile Asp Ala Gln Leu Gly Asp Ala Arg Asp 530 535 540 Ala Arg Ala Asp Ala Ala Ala Gln Leu Ser Lys Ala Gln Ser Gln Leu 545 550 555 560 Asp Ala Thr Thr Val Leu Ser Thr Leu Glu Gly Thr Val Val Glu Val 565 570 575 Asn Ser Asn Val Ser Lys Ser Pro Thr Gly Ala Ser Gln Val Met Val 580 585 590 His Ile Val Ser Asn Glu Asn Leu Gln Val Lys Gly Glu Leu Ser Glu 595 600 605 Tyr Asn Leu Ala Asn Leu Ser Val Gly Gln Glu Val Ser Phe Thr Ser 610 615 620 Lys Val Tyr Pro Asp Lys Lys Trp Thr Gly Lys Leu Ser Tyr Ile Ser 625 630 635 640 Asp Tyr Pro Lys Asn Asn Gly Glu Ala Ala Ser Pro Ala Ala Gly Asn 645 650 655 Asn Thr Gly Ser Lys Tyr Pro Tyr Thr Ile Asp Val Thr Gly Glu Val 660 665 670 Gly Asp Leu Lys Gln Gly Phe Ser Val Asn Ile Glu Val Lys Ser Lys 675 680 685 Thr Lys Ala Ile Leu Val Pro Val Ser Ser Leu Val Met Asp Asp Ser 690 695 700 Lys Asn Tyr Val Trp Ile Val Asp Glu Gln Gln Lys Ala Lys Lys Val 705 710 715 720 Glu Val Ser Leu Gly Asn Ala Asp Ala Glu Asn Gln Glu Ile Thr Ser 725 730 735 Gly Leu Thr Asn Gly Ala Lys Val Ile Ser Asn Pro Thr Ser Ser Leu 740 745 750 Glu Glu Gly Lys Glu Val Lys Ala Asp Glu Ala Thr Asn 755 760 765 <210> 7 <211> 1101 <212> ADN <213> Streptococcus pneumoniae <400> 7 tttagacaac cttctcagac tgctctaaaa gatgagccta ctcatcttgt tgttgccaag 60 gaaggaagcg tggcctcctc tgttttattg tcagggacag taacagcaaa aaatgaacaa 120 tatgtttatt ttgatgctag taagggtgat ttagatgaaa tccttgtttc tgtgggcgat 180 aaggtcagcg aagggcaggc tttagtcaag tacagtagtt cagaagcgca ggcggcctat 240 gattcagcta gtcgagcagt agctagggca gatcgtcata tcaatgaact caatcaagca 300 cgaaatgaag ccgcttcagc tccggctcca cagttaccag cgccagtagg aggagaagat 360 gcaacggtgc aaagcccaac tccagtggct ggaaattctg ttgcttctat tgacgctcaa 420 ttgggtgatg cccgtgatgc gcgtgcagat gctgcggcgc aattaagcaa ggctcaaagt 480 caattggatg caacaactgt tctcagtacc ctagagggaa ctgtggtcga agtcaatagc 540 aatgtttcta aatctccaac aggggcgagt caagttatgg ttcatattgt cagcaatgaa 600 aatttacaag tcaagggaga attgtctgag tacaatctag ccaacctttc tgtaggtcaa 660 gaagtaagct ttacttctaa agtgtatcct gataaaaaat ggactgggaa attaagctat 720 atttctgact atcctaaaaa caatggtgaa gcagctagtc cagcagccgg gaataataca 780 ggttctaaat acccttatac tattgatgtg acaggcgagg ttggtgattt gaaacaaggt 840 ttttctgtca acattgaggt taaaagcaaa actaaggcta ttcttgttcc tgttagcagt 900 ctagtaatgg atgatagtaa aaattatgtc tggattgtgg atgaacaaca aaaggctaaa 960 aaagttgagg tttcattggg aaatgctgac gcagaaaatc aagaaatcac ttctggttta 1020 acgaacggtg ctaaggtcat cagtaatcca acatcttcct tggaagaagg aaaagaggtg 1080 aaggctgatg aagcaactaa t 1101 <210> 8 <211> 756 <212> ADN <213> Streptococcus pneumoniae <400> 8 actagtggag ataattggtc aaagtaccag tctaacaagt ctattactat tggatttgat 60 agtacttttg ttccaatggg atttgctcag aaagatggtt cttatgcagg atttgatatt 120 gatttagcta cagctgtttt tgaaaaatac ggaatcacgg taaattggca accgattgat 180 tgggatttga aagaagctga attgacaaaa ggaacgattg atctgatttg gaatggctat 240 tccgctacag acgaacgccg tgaaaaggtg gctttcagta actcatatat gaagaatgag 300 caggtattgg ttacgaagaa atcatctggt atcacgactg caaaggatat gactggaaag 360 acattaggag ctcaagctgg ttcatctggt tatgcggact ttgaagcaaa tccagaaatt 420 ttgaagaata ttgtcgctaa taaggaagcg aatcaatacc aaacctttaa tgaagccttg 480 attgatttga aaaacgatcg aattgatggt ctattgattg accgtgtcta tgcaaactat 540 tatttagaag cagaaggtgt tttaaacgat tataatgtct ttacagttgg actagaaaca 600 gaagcttttg cggttggagc ccgtaaggaa gatacaaact tggttaagaa gataaatgaa 660 gctttttcta gtctttacaa ggacggcaag ttccaagaaa tcagccaaaa atggtttgga 720 gaagatgtag caaccaaaga agtaaaagaa ggacag 756 <210> 9 <211> 2295 <212> ADN <213> Secuencia artificial <220> <223> Descripción de secuencia artificial: Polinucleótido sintético <400> 9 atgttcgacg catccaactt taaagacttt agcagcatcg cgtccgcaag ctctagctgg 60 cagaatcaat ctggtagcac catgattatc caagtggaca gctttggtaa cgtcagcggt 120 caatatgtta atcgtgcaca gggtacgggt tgtcagaatt ctccgtaccc gctgaccggt 180 cgtgttaacg gcacgttcat cgctttcagc gtcggttgga acaattctac tgaaaattgc 240 aacagcgcga ccggttggac gggctatgca caagtgaatg gcaataacac cgaaatcgtc 300 acgtcctgga atctggcgta tgagggtggc agcggtccgg ctattgaaca gggccaggat 360 accttccaat acgtccctac gaccgagaat aagtcccttc tgaaagacgg cggtggcggt 420 tcgagctcga ccagcggcga caattggtcc aaataccaga gcaacaagag catcacgatc 480 ggcttcgaca gcacttttgt gccgatgggt ttcgcgcaaa aagacggtag ctacgcgggt 540 ttcgatattg acctggcgac cgctgtcttt gagaaatacg gcattacggt taattggcag 600 ccgattgatt gggacctgaa agaggccgaa ctcaccaaag gcaccatcga cctgatctgg 660 aatggttact ccgcaaccga tgagcgtcgc gaaaaagttg ccttcagcaa cagctatatg 720 aagaatgaac aagtgttggt aaccaagaaa tctagcggca ttacgaccgc gaaagacatg 780 accggtaaga cgctgggtgc gcaggccggt agctctggct atgcggattt cgaggcgaat 840 cctgagattc tgaaaaacat cgttgcgaat aaagaggcga accagtacca gacctttaac 900 gaagcactga tcgacctgaa aaacgatcgc attgacggtc tgctgatcga tcgtgtgtac 960 gcgaactatt atctggaagc cgagggcgtt ctgaacgatt ataatgtttt taccgtgggt 1020 ctggagactg aggcattcgc ggttggtgcg cgcaaggaag ataccaacct ggttaaaaag 1080 attaatgagg catttagctc actgtacaag gacggcaagt tccaagaaat tagccagaag 1140 tggttcggtg aagatgttgc gacgaaagag gttaaagagg gccaagcggc cgcatttcgc 1200 caaccgagcc agactgcgtt gaaagatgag ccgacccatc tggttgttgc gaaagagggc 1260 agcgtggcat cgagcgtgct gctgagcggt acggttactg ccaaaaacga acaatacgtg 1320 tacttcgatg ctagcaaggg tgatctggat gaaattctgg tgagcgtggg tgacaaagtt 1380 agcgaaggcc aggcactggt gaagtattca tcctccgagg cacaggcagc gtacgacagc 1440 gcaagccgcg cagtggcgcg tgccgaccgt cacattaacg aattgaacca agcgcgtaac 1500 gaggccgcaa gcgcgccagc accgcagctg ccggctccgg tgggtggcga agatgcgacg 1560 gtgcagagcc cgaccccggt tgcgggtaat tcggtcgcca gcatcgatgc gcagctgggt 1620 gacgcgcgtg atgcccgtgc ggatgcggct gctcaactga gcaaggctca gagccaactg 1680 gacgcgacga cggtgctgag caccttggag ggtaccgttg tcgaagtcaa cagcaatgtg 1740 agcaagagcc caacgggtgc gagccaggtt atggtccaca ttgtgagcaa tgaaaactta 1800 caggtcaagg gtgagctgag cgagtataac ctggcgaatc tgagcgttgg tcaagaggtc 1860 agctttacca gcaaggtcta cccggataag aaatggaccg gcaagttgag ctacatcagc 1920 gactacccga agaacaatgg cgaggcagcc tccccggcag ccggcaacaa taccggctct 1980 aagtatccgt acaccatcga cgtaaccggt gaggtcggcg acctgaaaca gggttttagc 2040 gtgaatatcg aagtgaagtc caagaccaag gcaattttgg ttccggttag ctccctggtg 2100 atggacgata gcaagaatta tgtgtggatt gtcgacgagc aacagaaagc gaaaaaagtt 2160 gaagtgagcc tgggcaatgc tgatgccgag aaccaagaaa tcacgtctgg tctgaccaac 2220 ggtgcgaaag ttattagcaa cccgaccagc agcctggaag agggtaaaga ggtcaaagcc 2280 gacgaagcta cgaac 2295 <210> 10 <211> 399 <212> PRT <213> Streptococcus pneumoniae <400> 10 Met Lys Lys Lys Asn Gly Lys Ala Lys Lys Trp Gln Leu Tyr Ala Ala 1 5 10 15 Ile Gly Ala Ala Ser Val Val Val Leu Gly Ala Gly Gly Ile Leu Leu 20 25 30 Phe Arg Gln Pro Ser Gln Thr Ala Leu Lys Asp Glu Pro Thr His Leu 35 40 45 Val Val Ala Lys Glu Gly Ser Val Ala Ser Ser Val Leu Leu Ser Gly 50 55 60 Thr Val Thr Ala Lys Asn Glu Gln Tyr Val Tyr Phe Asp Ala Ser Lys 65 70 75 80 Gly Asp Leu Asp Glu Ile Leu Val Ser Val Gly Asp Lys Val Ser Glu 85 90 95 Gly Gln Ala Leu Val Lys Tyr Ser Ser Ser Glu Ala Gln Ala Ala Tyr 100 105 110 Asp Ser Ala Ser Arg Ala Val Ala Arg Ala Asp Arg His Ile Asn Glu 115 120 125 Leu Asn Gln Ala Arg Asn Glu Ala Ala Ser Ala Pro Ala Pro Gln Leu 130 135 140 Pro Ala Pro Val Gly Gly Glu Asp Ala Thr Val Gln Ser Pro Thr Pro 145 150 155 160 Val Ala Gly Asn Ser Val Ala Ser Ile Asp Ala Gln Leu Gly Asp Ala 165 170 175 Arg Asp Ala Arg Ala Asp Ala Ala Ala Gln Leu Ser Lys Ala Gln Ser 180 185 190 Gln Leu Asp Ala Thr Thr Val Leu Ser Thr Leu Glu Gly Thr Val Val 195 200 205 Glu Val Asn Ser Asn Val Ser Lys Ser Pro Thr Gly Ala Ser Gln Val 210 215 220 Met Val His Ile Val Ser Asn Glu Asn Leu Gln Val Lys Gly Glu Leu 225 230 235 240 Ser Glu Tyr Asn Leu Ala Asn Leu Ser Val Gly Gln Glu Val Ser Phe 245 250 255 Thr Ser Lys Val Tyr Pro Asp Lys Lys Trp Thr Gly Lys Leu Ser Tyr 260 265 270 Ile Ser Asp Tyr Pro Lys Asn Asn Gly Glu Ala Ala Ser Pro Ala Ala 275 280 285 Gly Asn Asn Thr Gly Ser Lys Tyr Pro Tyr Thr Ile Asp Val Thr Gly 290 295 300 Glu Val Gly Asp Leu Lys Gln Gly Phe Ser Val Asn Ile Glu Val Lys 305 310 315 320 Ser Lys Thr Lys Ala Ile Leu Val Pro Val Ser Ser Leu Val Met Asp 325 330 335 Asp Ser Lys Asn Tyr Val Trp Ile Val Asp Glu Gln Gln Lys Ala Lys 340 345 350 Lys Val Glu Val Ser Leu Gly Asn Ala Asp Ala Glu Asn Gln Glu Ile 355 360 365 Thr Ser Gly Leu Thr Asn Gly Ala Lys Val Ile Ser Asn Pro Thr Ser 370 375 380 Ser Leu Glu Glu Gly Lys Glu Val Lys Ala Asp Glu Ala Thr Asn 385 390 395 <210> 11 <211> 1197 <212> ADN <213> Streptococcus pneumoniae <400> 11 atgaagaaaa agaatggtaa agctaaaaag tggcaactgt atgcagcaat cggtgctgcg 60 agtgtagttg tattgggtgc tggggggatt ttactcttta gacaaccttc tcagactgct 120 ctaaaagatg agcctactca tcttgttgtt gccaaggaag gaagcgtggc ctcctctgtt 180 ttattgtcag ggacagtaac agcaaaaaat gaacaatatg tttattttga tgctagtaag 240 ggtgatttag atgaaatcct tgtttctgtg ggcgataagg tcagcgaagg gcaggcttta 300 gtcaagtaca gtagttcaga agcgcaggcg gcctatgatt cagctagtcg agcagtagct 360 agggcagatc gtcatatcaa tgaactcaat caagcacgaa atgaagccgc ttcagctccg 420 gctccacagt taccagcgcc agtaggagga gaagatgcaa cggtgcaaag cccaactcca 480 gtggctggaa attctgttgc ttctattgac gctcaattgg gtgatgcccg tgatgcgcgt 540 gcagatgctg cggcgcaatt aagcaaggct caaagtcaat tggatgcaac aactgttctc 600 agtaccctag agggaactgt ggtcgaagtc aatagcaatg tttctaaatc tccaacaggg 660 gcgagtcaag ttatggttca tattgtcagc aatgaaaatt tacaagtcaa gggagaattg 720 tctgagtaca atctagccaa cctttctgta ggtcaagaag taagctttac ttctaaagtg 780 tatcctgata aaaaatggac tgggaaatta agctatattt ctgactatcc taaaaacaat 840 ggtgaagcag ctagtccagc agccgggaat aatacaggtt ctaaataccc ttatactatt 900 gatgtgacag gcgaggttgg tgatttgaaa caaggttttt ctgtcaacat tgaggttaaa 960 agcaaaacta aggctattct tgttcctgtt agcagtctag taatggatga tagtaaaaat 1020 tatgtctgga ttgtggatga acaacaaaag gctaaaaaag ttgaggtttc attgggaaat 1080 gctgacgcag aaaatcaaga aatcacttct ggtttaacga acggtgctaa ggtcatcagt 1140 aatccaacat cttccttgga agaaggaaaa gaggtgaagg ctgatgaagc aactaat 1197 <210> 12 <211> 278 <212> PRT <213> Streptococcus pneumoniae <400> 12 Met Lys Lys Trp Met Leu Val Leu Val Ser Leu Met Thr Ala Leu Phe 1 5 10 15 Leu Val Ala Cys Gly Lys Asn Ser Ser Glu Thr Ser Gly Asp Asn Trp 20 25 30 Ser Lys Tyr Gln Ser Asn Lys Ser Ile Thr Ile Gly Phe Asp Ser Thr 35 40 45 Phe Val Pro Met Gly Phe Ala Gln Lys Asp Gly Ser Tyr Ala Gly Phe 50 55 60 Asp Ile Asp Leu Ala Thr Ala Val Phe Glu Lys Tyr Gly Ile Thr Val 65 70 75 80 Asn Trp Gln Pro Ile Asp Trp Asp Leu Lys Glu Ala Glu Leu Thr Lys 85 90 95 Gly Thr Ile Asp Leu Ile Trp Asn Gly Tyr Ser Ala Thr Asp Glu Arg 100 105 110 Arg Glu Lys Val Ala Phe Ser Asn Ser Tyr Met Lys Asn Glu Gln Val 115 120 125 Leu Val Thr Lys Lys Ser Ser Gly Ile Thr Thr Ala Lys Asp Met Thr 130 135 140 Gly Lys Thr Leu Gly Ala Gln Ala Gly Ser Ser Gly Tyr Ala Asp Phe 145 150 155 160 Glu Ala Asn Pro Glu Ile Leu Lys Asn Ile Val Ala Asn Lys Glu Ala 165 170 175 Asn Gln Tyr Gln Thr Phe Asn Glu Ala Leu Ile Asp Leu Lys Asn Asp 180 185 190 Arg Ile Asp Gly Leu Leu Ile Asp Arg Val Tyr Ala Asn Tyr Tyr Leu 195 200 205 Glu Ala Glu Gly Val Leu Asn Asp Tyr Asn Val Phe Thr Val Gly Leu 210 215 220 Glu Thr Glu Ala Phe Ala Val Gly Ala Arg Lys Glu Asp Thr Asn Leu 225 230 235 240 Val Lys Lys Ile Asn Glu Ala Phe Ser Ser Leu Tyr Lys Asp Gly Lys 245 250 255 Phe Gln Glu Ile Ser Gln Lys Trp Phe Gly Glu Asp Val Ala Thr Lys 260 265 270 Glu Val Lys Glu Gly Gln 275 <210> 13 <211> 834 <212> ADN <213> Streptococcus pneumoniae <400> 13 atgaaaaaat ggatgcttgt attagtcagt ctgatgactg ctttgttctt agtagcttgt 60 gggaaaaatt ctagcgaaac tagtggagat aattggtcaa agtaccagtc taacaagtct 120 attactattg gatttgatag tacttttgtt ccaatgggat ttgctcagaa agatggttct 180 tatgcaggat ttgatattga tttagctaca gctgtttttg aaaaatacgg aatcacggta 240 aattggcaac cgattgattg ggatttgaaa gaagctgaat tgacaaaagg aacgattgat 300 ctgatttgga atggctattc cgctacagac gaacgccgtg aaaaggtggc tttcagtaac 360 tcatatatga agaatgagca ggtattggtt acgaagaaat catctggtat cacgactgca 420 aaggatatga ctggaaagac attaggagct caagctggtt catctggtta tgcggacttt 480 gaagcaaatc cagaaatttt gaagaatatt gtcgctaata aggaagcgaa tcaataccaa 540 acctttaatg aagccttgat tgatttgaaa aacgatcgaa ttgatggtct attgattgac 600 cgtgtctatg caaactatta tttagaagca gaaggtgttt taaacgatta taatgtcttt 660 acagttggac tagaaacaga agcttttgcg gttggagccc gtaaggaaga tacaaacttg 720 gttaagaaga taaatgaagc tttttctagt ctttacaagg acggcaagtt ccaagaaatc 780 agccaaaaat ggtttggaga agatgtagca accaaagaag taaaagaagg acag 834 <210> 14 <211> 4 <212> PRT <213> Secuencia artificial <220> <223> Descripción de secuencia artificial: Péptido sintético <400> 14 Gly Gly Gly Gly 1