LISTADO DE SECUENCIAS <110> GENZYME CORPORATION <120> GENERACIÓN DE PAH HUMANA MEJORADA PARA EL TRATAMIENTO DE PKU GRAVE MEDIANTE TERAPIA DE SUSTITUCIÓN DE GENES DIRIGIDA AL HÍGADO <130> 15979-20166.00 <140> Not Yet Assigned <141> Concurrently Herewith <150> US 62/744,944 <151> 2018-10-12 <160> 18 <170> FastSEQ for Windows Version 4.0 <210> 1 <211> 452 <212> PRT <213> Homo sapiens <400> 1 Met Ser Thr Ala Val Leu Glu Asn Pro Gly Leu Gly Arg Lys Leu Ser 1 5 10 15 Asp Phe Gly Gln Glu Thr Ser Tyr Ile Glu Asp Asn Cys Asn Gln Asn 20 25 30 Gly Ala Ile Ser Leu Ile Phe Ser Leu Lys Glu Glu Val Gly Ala Leu 35 40 45 Ala Lys Val Leu Arg Leu Phe Glu Glu Asn Asp Val Asn Leu Thr His 50 55 60 Ile Glu Ser Arg Pro Ser Arg Leu Lys Lys Asp Glu Tyr Glu Phe Phe 65 70 75 80 Thr His Leu Asp Lys Arg Ser Leu Pro Ala Leu Thr Asn Ile Ile Lys 85 90 95 Ile Leu Arg His Asp Ile Gly Ala Thr Val His Glu Leu Ser Arg Asp 100 105 110 Lys Lys Lys Asp Thr Val Pro Trp Phe Pro Arg Thr Ile Gln Glu Leu 115 120 125 Asp Arg Phe Ala Asn Gln Ile Leu Ser Tyr Gly Ala Glu Leu Asp Ala 130 135 140 Asp His Pro Gly Phe Lys Asp Pro Val Tyr Arg Ala Arg Arg Lys Gln 145 150 155 160 Phe Ala Asp Ile Ala Tyr Asn Tyr Arg His Gly Gln Pro Ile Pro Arg 165 170 175 Val Glu Tyr Met Glu Glu Glu Lys Lys Thr Trp Gly Thr Val Phe Lys 180 185 190 Thr Leu Lys Ser Leu Tyr Lys Thr His Ala Cys Tyr Glu Tyr Asn His 195 200 205 Ile Phe Pro Leu Leu Glu Lys Tyr Cys Gly Phe His Glu Asp Asn Ile 210 215 220 Pro Gln Leu Glu Asp Val Ser Gln Phe Leu Gln Thr Cys Thr Gly Phe 225 230 235 240 Arg Leu Arg Pro Val Ala Gly Leu Leu Ser Ser Arg Asp Phe Leu Gly 245 250 255 Gly Leu Ala Phe Arg Val Phe His Cys Thr Gln Tyr Ile Arg His Gly 260 265 270 Ser Lys Pro Met Tyr Thr Pro Glu Pro Asp Ile Cys His Glu Leu Leu 275 280 285 Gly His Val Pro Leu Phe Ser Asp Arg Ser Phe Ala Gln Phe Ser Gln 290 295 300 Glu Ile Gly Leu Ala Ser Leu Gly Ala Pro Asp Glu Tyr Ile Glu Lys 305 310 315 320 Leu Ala Thr Ile Tyr Trp Phe Thr Val Glu Phe Gly Leu Cys Lys Gln 325 330 335 Gly Asp Ser Ile Lys Ala Tyr Gly Ala Gly Leu Leu Ser Ser Phe Gly 340 345 350 Glu Leu Gln Tyr Cys Leu Ser Glu Lys Pro Lys Leu Leu Pro Leu Glu 355 360 365 Leu Glu Lys Thr Ala Ile Gln Asn Tyr Thr Val Thr Glu Phe Gln Pro 370 375 380 Leu Tyr Tyr Val Ala Glu Ser Phe Asn Asp Ala Lys Glu Lys Val Arg 385 390 395 400 Asn Phe Ala Ala Thr Ile Pro Arg Pro Phe Ser Val Arg Tyr Asp Pro 405 410 415 Tyr Thr Gln Arg Ile Glu Val Leu Asp Asn Thr Gln Gln Leu Lys Ile 420 425 430 Leu Ala Asp Ser Ile Asn Ser Glu Ile Gly Ile Leu Cys Ser Ala Leu 435 440 445 Gln Lys Ile Lys 450 <210> 2 <211> 452 <212> PRT <213> Homo sapiens <400> 2 Met Ser Thr Ala Val Leu Glu Asn Pro Gly Leu Gly Arg Lys Leu Ser 1 5 10 15 Asp Phe Gly Gln Glu Thr Ser Tyr Ile Glu Asp Asn Cys Asn Gln Asn 20 25 30 Gly Ala Ile Ser Leu Ile Phe Ser Leu Lys Glu Glu Val Gly Ala Leu 35 40 45 Ala Lys Val Leu Arg Leu Phe Glu Glu Asn Asp Val Asn Leu Thr His 50 55 60 Ile Glu Ser Arg Pro Ser Arg Leu Lys Lys Asp Glu Tyr Glu Phe Phe 65 70 75 80 Thr His Leu Asp Lys Arg Ser Leu Pro Ala Leu Thr Asn Ile Ile Lys 85 90 95 Ile Leu Arg His Asp Ile Gly Ala Thr Val His Glu Leu Ser Arg Asp 100 105 110 Lys Lys Lys Asp Thr Val Pro Trp Phe Pro Arg Thr Ile Gln Glu Leu 115 120 125 Asp Arg Phe Ala Asn Gln Ile Leu Ser Tyr Gly Ala Glu Leu Asp Ala 130 135 140 Asp His Pro Gly Phe Lys Asp Pro Val Tyr Arg Ala Arg Arg Lys Gln 145 150 155 160 Phe Ala Asp Ile Ala Tyr Asn Tyr Arg His Gly Gln Pro Ile Pro Arg 165 170 175 Val Glu Tyr Met Glu Glu Gly Lys Lys Thr Trp Gly Thr Val Phe Lys 180 185 190 Thr Leu Lys Ser Leu Tyr Lys Thr His Ala Cys Tyr Glu Tyr Asn His 195 200 205 Ile Phe Pro Leu Leu Glu Lys Tyr Cys Gly Phe His Glu Asp Asn Ile 210 215 220 Pro Gln Leu Glu Asp Val Ser Gln Phe Leu Gln Thr Cys Thr Gly Phe 225 230 235 240 Arg Leu Arg Pro Val Ala Gly Leu Leu Ser Ser Arg Asp Phe Leu Gly 245 250 255 Gly Leu Ala Phe Arg Val Phe His Cys Thr Gln Tyr Ile Arg His Gly 260 265 270 Ser Lys Pro Met Tyr Thr Pro Glu Pro Asp Ile Cys His Glu Leu Leu 275 280 285 Gly His Val Pro Leu Phe Ser Asp Arg Ser Phe Ala Gln Phe Ser Gln 290 295 300 Glu Ile Gly Leu Ala Ser Leu Gly Ala Pro Asp Glu Tyr Ile Glu Lys 305 310 315 320 Leu Ala Thr Ile Tyr Trp Phe Thr Val Glu Phe Gly Leu Cys Lys Gln 325 330 335 Gly Asp Ser Ile Lys Ala Tyr Gly Ala Gly Leu Leu Ser Ser Phe Gly 340 345 350 Glu Leu Gln Tyr Cys Leu Ser Glu Lys Pro Lys Leu Leu Pro Leu Glu 355 360 365 Leu Glu Lys Thr Ala Ile Gln Asn Tyr Thr Val Thr Glu Phe Gln Pro 370 375 380 Leu Tyr Tyr Val Ala Glu Ser Phe Asn Asp Ala Lys Glu Lys Val Arg 385 390 395 400 Asn Phe Ala Ala Thr Ile Pro Arg Pro Phe Ser Val Arg Tyr Asp Pro 405 410 415 Tyr Thr Gln Arg Ile Glu Val Leu Asp Asn Thr Gln Gln Leu Lys Ile 420 425 430 Leu Ala Asp Ser Ile Asn Ser Glu Ile Gly Ile Leu Cys Ser Ala Leu 435 440 445 Gln Lys Ile Lys 450 <210> 3 <211> 452 <212> PRT <213> Homo sapiens <400> 3 Met Ser Thr Ala Val Leu Glu Asn Pro Gly Leu Gly Arg Lys Leu Ser 1 5 10 15 Asp Phe Gly Gln Glu Thr Ser Tyr Ile Glu Asp Asn Cys Asn Gln Asn 20 25 30 Gly Ala Ile Ser Leu Ile Phe Ser Leu Lys Glu Glu Val Gly Ala Leu 35 40 45 Ala Lys Val Leu Arg Leu Phe Glu Glu Asn Asp Val Asn Leu Thr His 50 55 60 Ile Glu Ser Arg Pro Ser Arg Leu Lys Lys Asp Glu Tyr Glu Phe Phe 65 70 75 80 Thr His Leu Asp Lys Arg Ser Leu Pro Ala Leu Thr Asn Ile Ile Lys 85 90 95 Ile Leu Arg His Asp Ile Gly Ala Thr Val His Glu Leu Ser Arg Asp 100 105 110 Lys Lys Lys Asp Thr Val Pro Trp Phe Pro Arg Thr Ile Gln Glu Leu 115 120 125 Asp Arg Phe Ala Asn Gln Ile Leu Ser Tyr Gly Ala Glu Leu Asp Ala 130 135 140 Asp His Pro Gly Phe Lys Asp Pro Val Tyr Arg Ala Arg Arg Lys Gln 145 150 155 160 Phe Ala Asp Ile Ala Tyr Asn Tyr Arg His Gly Gln Pro Ile Pro Arg 165 170 175 Val Glu Tyr Thr Glu Glu Glu Lys Lys Thr Trp Gly Thr Val Phe Lys 180 185 190 Thr Leu Lys Ser Leu Tyr Pro Thr His Ala Cys Tyr Glu Tyr Asn His 195 200 205 Ile Phe Pro Leu Leu Glu Lys Tyr Cys Gly Phe His Glu Asp Asn Ile 210 215 220 Pro Gln Leu Glu Asp Val Ser Gln Phe Leu Gln Thr Cys Thr Gly Phe 225 230 235 240 Arg Leu Arg Pro Val Ala Gly Leu Leu Pro Ser Arg Asp Phe Leu Ala 245 250 255 Gly Leu Ala Phe Arg Val Phe His Cys Thr Gln Tyr Ile Arg His Gly 260 265 270 Ser Lys Pro Met Tyr Thr Pro Glu Pro Asp Ile Cys His Glu Leu Leu 275 280 285 Gly His Val Pro Leu Phe Ser Asp Arg Ser Phe Ala Gln Phe Ser Gln 290 295 300 Glu Ile Gly Leu Ala Ser Leu Gly Ala Pro Asp Glu Tyr Ile Glu Lys 305 310 315 320 Leu Ala Thr Ile Tyr Trp Phe Thr Val Glu Phe Gly Leu Cys Lys Gln 325 330 335 Gly Asp Ser Ile Lys Ala Tyr Gly Ala Gly Leu Leu Ser Ser Phe Gly 340 345 350 Glu Leu Gln Tyr Cys Leu Ser Glu Lys Pro Lys Leu Leu Pro Leu Glu 355 360 365 Leu Glu Lys Thr Ala Ile Gln Asn Tyr Thr Val Thr Glu Phe Gln Pro 370 375 380 Leu Tyr Tyr Val Ala Glu Ser Phe Asn Asp Ala Lys Glu Lys Val Arg 385 390 395 400 Asn Phe Ala Ala Thr Ile Pro Arg Pro Phe Ser Val Arg Tyr Asp Pro 405 410 415 Tyr Thr Gln Arg Ile Glu Val Leu Asp Asn Thr Gln Gln Leu Lys Ile 420 425 430 Leu Ala Asp Ser Ile Asn Ser Glu Ile Gly Ile Leu Cys Ser Ala Leu 435 440 445 Gln Lys Ile Lys 450 <210> 4 <211> 1359 <212> DNA <213> Homo sapiens <400> 4 atgagcacag ccgtgctgga aaaccccggc ctgggcagaa agctgagcga cttcggccag 60 gaaaccagct acatcgagga caactgcaac cagaacggcg ccatcagcct gatcttcagc 120 ctgaaagaag aagtgggcgc cctggccaag gtgctgcggc tgttcgagga gaacgacgtg 180 aacctgaccc acatcgagag ccggcccagc agactgaaga aggacgagta cgagttcttc 240 acccacctgg acaagcggag cctgcccgcc ctgaccaaca tcatcaagat cctgcggcac 300 gacatcggcg ccaccgtgca cgagctgagc cgggacaaga aaaaggacac cgtgccctgg 360 ttccccagaa ccatccagga actggacaga ttcgccaacc agatcctgtc ctacggcgcc 420 gagctggatg ccgaccaccc tggcttcaag gaccccgtgt accgggccag acggaagcag 480 ttcgccgata tcgcctacaa ctaccggcac ggccagccca tccccagagt cgagtacacc 540 gaagagggca agaaaacctg gggcaccgtg ttcaagaccc tgaagtccct gtaccccacc 600 cacgcctgct acgagtacaa ccacatcttc ccactgctcg aaaagtactg cggcttccac 660 gaggacaata tccctcagct ggaggacgtg tcccagtttc tgcagacctg caccggcttc 720 agactcaggc ctgtggccgg cctgctgccc agcagagatt ttctggccgg actggccttc 780 cgggtgttcc actgcaccca gtacatcaga cacggcagca agcccatgta cacccctgag 840 cccgacatct gccacgagct gctgggacat gtgcccctgt tcagcgacag aagcttcgcc 900 cagttcagcc aggaaatcgg cctggcctct ctgggcgctc ccgacgagta tatcgagaag 960 ctggccacca tctactggtt caccgtggaa ttcggcctgt gcaagcaggg cgacagcatc 1020 aaggcctatg gcgccggact cctgtccagc ttcggcgagc tgcagtactg tctgagcgag 1080 aagcccaagc tgctgcccct ggaactggaa aagaccgcca tccagaacta caccgtgacc 1140 gagttccagc ccctgtacta cgtggccgag agcttcaacg acgccaaaga aaaagtgcgg 1200 aacttcgccg ccaccatccc tcggcccttc agcgtcagat acgaccccta cacccagcgg 1260 atcgaggtgc tggacaacac acagcagctg aaaattctgg ccgactccat caacagcgag 1320 atcggcatcc tgtgcagcgc cctgcagaaa atcaagtga 1359 <210> 5 <211> 3713 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Construct <400> 5 gagctcttgg ccactccctc tctgcgcgct cgctcgctca ctgaggccgg gcgaccaaag 60 gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc gcgcagagag 120 ggagtggcca actccatcac taggggttcc tacgcgtggc cccaggttaa tttttaaaaa 180 gcagtcaaag gtcaaagtgg cccttggcag catttactct ctctattgac tttggttaat 240 aatctcagga gcacaaacat tcctggaggc aggagaagaa atcaacatcc tggacttatc 300 ctctgggcct ctccccacct tcgatggccc caggttaatt tttaaaaagc agtcaaaggt 360 caaagtggcc cttggcagca tttactctct ctattgactt tggttaataa tctcaggagc 420 acaaacattc ctggaggcag gagaagaaat caacatcctg gacttatcct ctgggcctct 480 ccccaccgat atctacctgc tgatcgcccg gcccctgttc aaacatgtcc taatactctg 540 tcggggcaaa ggtcggcagt agttttccat cttactcaac atcctcccag tgtacgtagg 600 atcctgtctg tctgcacatt tcgtagagcg agtgttccga tactctaatc tcccggggca 660 aaggtcgtat tgacttaggt tacttattct ccttttgttg actaagtcaa taatcagaat 720 cagcaggttt ggagtcagct tggcagggat cagcagcctg ggttggaagg agggggtata 780 aaagcccctt caccaggaga agccgtcaca cagatccaca agctcctgct agcagtcgct 840 gcgcgctgcc ttcgccccgt gccccgctcc gccgccgcct cgcgccgccc gccccggctc 900 tgactgaccg cgttactccc acaggtgagc gggcgggacg gcccttctcc tccgggctgt 960 aattagcgct tggtttaatg acggcttgtt tcttttctgt ggctgcgtga aagccttgag 1020 gggctccggg aaggcccttt gtgcgggggg agcggctcgg ggggtgcgtg cgtgtgtgtg 1080 tgcgtgggga gcgccgcgtg cggctccgcg ctgcccggcg gctgtgagcg ctgcgggcgc 1140 ggcgcggggc tttgtgcgct ccgcagtgtg cgcgagggga gcggggccgg gggcggtgcc 1200 ccgcggtgcg gggggggctg cgaggggaac aaaggctgcg tgcggggtgt gtgcgtgggg 1260 gggtgagcag ggggtgtggg cgcgtcggtc gggctgcaac cccccctgca cccccctccc 1320 cgagttgctg agcacggccc ggcttcgggt gcggggctcc gtacggggcg tggcgcgggg 1380 ctcgccgtgc cgggcggggg gtggcggcag gtgggggtgc cgggcggggc ggggccgcct 1440 cgggccgggg agggctcggg ggaggggcgc ggcggccccc ggagcgccgg cggctgtcga 1500 ggcgcggcga gccgcagcca ttgcctttta tggtaatcgt gcgagagggc gcagggactt 1560 cctttgtccc aaatctgtgc ggagccgaaa tctgggaggc gccgccgcac cccctctagc 1620 gggcgcgggg cgaagcggtg cggcgccggc aggaaggaaa tgggcgggga gggccttcgt 1680 gcgtcgccgc gccgccgtcc ccttctccct ctccagcctc ggggctgtcc gcggggggac 1740 ggctgccttc gggggggacg gggcagggcg gggttcggct tctggcgtgt gaccggcggc 1800 tctagagcct ctgctaacca tgttcatgcc ttcttctttt tcctacagct cctgggcaac 1860 gtgctggtta ttgtgctgtc tcatcatttt ggcaaagaat tcatttcgaa gccgccacca 1920 tgagcacagc cgtgctggaa aaccccggcc tgggcagaaa gctgagcgac ttcggccagg 1980 aaaccagcta catcgaggac aactgcaacc agaacggcgc catcagcctg atcttcagcc 2040 tgaaagaaga agtgggcgcc ctggccaagg tgctgcggct gttcgaggag aacgacgtga 2100 acctgaccca catcgagagc cggcccagca gactgaagaa ggacgagtac gagttcttca 2160 cccacctgga caagcggagc ctgcccgccc tgaccaacat catcaagatc ctgcggcacg 2220 acatcggcgc caccgtgcac gagctgagcc gggacaagaa aaaggacacc gtgccctggt 2280 tccccagaac catccaggaa ctggacagat tcgccaacca gatcctgtcc tacggcgccg 2340 agctggatgc cgaccaccct ggcttcaagg accccgtgta ccgggccaga cggaagcagt 2400 tcgccgatat cgcctacaac taccggcacg gccagcccat ccccagagtc gagtacaccg 2460 aagagggcaa gaaaacctgg ggcaccgtgt tcaagaccct gaagtccctg taccccaccc 2520 acgcctgcta cgagtacaac cacatcttcc cactgctcga aaagtactgc ggcttccacg 2580 aggacaatat ccctcagctg gaggacgtgt cccagtttct gcagacctgc accggcttca 2640 gactcaggcc tgtggccggc ctgctgccca gcagagattt tctggccgga ctggccttcc 2700 gggtgttcca ctgcacccag tacatcagac acggcagcaa gcccatgtac acccctgagc 2760 ccgacatctg ccacgagctg ctgggacatg tgcccctgtt cagcgacaga agcttcgccc 2820 agttcagcca ggaaatcggc ctggcctctc tgggcgctcc cgacgagtat atcgagaagc 2880 tggccaccat ctactggttc accgtggaat tcggcctgtg caagcagggc gacagcatca 2940 aggcctatgg cgccggactc ctgtccagct tcggcgagct gcagtactgt ctgagcgaga 3000 agcccaagct gctgcccctg gaactggaaa agaccgccat ccagaactac accgtgaccg 3060 agttccagcc cctgtactac gtggccgaga gcttcaacga cgccaaagaa aaagtgcgga 3120 acttcgccgc caccatccct cggcccttca gcgtcagata cgacccctac acccagcgga 3180 tcgaggtgct ggacaacaca cagcagctga aaattctggc cgactccatc aacagcgaga 3240 tcggcatcct gtgcagcgcc ctgcagaaaa tcaagtgacc taggtgatca agatctgcta 3300 gcttaattaa cccgggacta gtgcggccgc tcgagactag tctgtgcctt ctagttgcca 3360 gccatctgtt gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg ccactcccac 3420 tgtcctttcc taataaaatg aggaaattgc atcgcattgt ctgagtaggt gtcattctat 3480 tctggggggt ggggtggggc aggacagcaa gggggaggat tgggaagaca atagcaggca 3540 tgctggggat gcggtgggct ctatggtacc aggaacccct agtgatggag ttggccactc 3600 cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg 3660 gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg gcc 3713 <210> 6 <211> 4561 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Construct <400> 6 ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgcccgggc aaagcccggg 60 cgtcgggcga cctttggtcg cccggcctca gtgagcgagc gagcgcgcag agagggagtg 120 gccaactcca tcactagggg ttccttaccg cgtggcccca ggttaatttt taaaaagcag 180 tcaaaggtca aagtggccct tggcagcatt tactctctct attgactttg gttaataatc 240 tcaggagcac aaacattcct ggaggcagga gaagaaatca acatcctgga cttatcctct 300 gggcctctcc ccaccttcga tggccccagg ttaattttta aaaagcagtc aaaggtcaaa 360 gtggcccttg gcagcattta ctctctctat tgactttggt taataatctc aggagcacaa 420 acattcctgg aggcaggaga agaaatcaac atcctggact tatcctctgg gcctctcccc 480 accgatatct acctgctgat cgcccggccc ctgttcaaac atgtcctaat actctgtcgg 540 ggcaaaggtc ggcagtagtt ttccatctta ctcaacatcc tcccagtgta cgtaggatcc 600 tgtctgtctg cacatttcgt agagcgagtg ttccgatact ctaatctccc ggggcaaagg 660 tcgtattgac ttaggttact tattctcctt ttgttgacta agtcaataat cagaatcagc 720 aggtttggag tcagcttggc agggatcagc agcctgggtt ggaaggaggg ggtataaaag 780 ccccttcacc aggagaagcc gtcacacaga tccacaagct cctgctagcc aattgagtcg 840 ctgcgcgctg ccttcgcccc gtgccccgct ccgccgccgc ctcgcgccgc ccgccccggc 900 tctgactgac cgcgttactc ccacaggtga gcgggcggga cggcccttct cctccgggct 960 gtaattagcg cttggtttat tgacggcttg tttcttttct gtggctgcgt gaaagccttg 1020 aggggctccg ggaaggccct ttgtgcgggg ggagcggctc ggggggtgcg tgcgtgtgtg 1080 tgtgcgtggg gagcgccgcg tgcggctccg cgctgcccgg cggctgtgag cgctgcgggc 1140 gcggcgcggg gctttgtgcg ctccgcagtg tgcgcgaggg gagcggggcc gggggcggtg 1200 ccccgcggtg cggggggggc tgcgagggga acaaaggctg cgtgcggggt gtgtgcgtgg 1260 gggggtgagc agggggtgtg ggcgcgtcgg tcgggctgca accccccctg cacccccctc 1320 cccgagttgc tgagcacggc ccggcttcgg gtgcggggct ccgtacgggg cgtggcgcgg 1380 ggctcgccgt gccgggcggg gggtggcggc aggtgggggt gccgggcggg gcggggccgc 1440 ctcgggccgg ggagggctcg ggggaggggc gcggcggccc ccggagcgcc ggcggctgtc 1500 gaggcgcggc gagccgcagc cattgccttt tttggtaatc gtgcgagagg gcgcagggac 1560 ttcctttgtc ccaaatctgt gcggagccga aatctgggag gcgccgccgc accccctcta 1620 gcgggcgcgg ggcgaagcgg tgcggcgccg gcaggaagga attgggcggg gagggccttc 1680 gtgcgtcgcc gcgccgccgt ccccttctcc ctctccagcc tcggggctgt ccgcgggggg 1740 acggctgcct tcggggggga cggggcaggg cggggttcgg cttctggcgt gtgaccggcg 1800 gctctagagc ctctgctaac cttgttcttg ccttcttctt tttcctacag ctcctgggca 1860 acgtgctggt tattgtgctg tctcatcatt ttggcaaaga attcatttcg aagccgccac 1920 catgagcaca gccgtgctgg aaaaccccgg cctgggcaga aagctgagcg acttcggcca 1980 ggaaaccagc tacatcgagg acaactgcaa ccagaacggc gccatcagcc tgatcttcag 2040 cctgaaagaa gaagtgggcg ccctggccaa ggtgctgcgg ctgttcgagg agaacgacgt 2100 gaacctgacc cacatcgaga gccggcccag cagactgaag aaggacgagt acgagttctt 2160 cacccacctg gacaagcgga gcctgcccgc cctgaccaac atcatcaaga tcctgcggca 2220 cgacatcggc gccaccgtgc acgagctgag ccgggacaag aaaaaggaca ccgtgccctg 2280 gttccccaga accatccagg aactggacag attcgccaac cagatcctgt cctacggcgc 2340 cgagctggat gccgaccacc ctggcttcaa ggaccccgtg taccgggcca gacggaagca 2400 gttcgccgat atcgcctaca actaccggca cggccagccc atccccagag tcgagtacac 2460 cgaagagggc aagaaaacct ggggcaccgt gttcaagacc ctgaagtccc tgtaccccac 2520 ccacgcctgc tacgagtaca accacatctt cccactgctc gaaaagtact gcggcttcca 2580 cgaggacaat atccctcagc tggaggacgt gtcccagttt ctgcagacct gcaccggctt 2640 cagactcagg cctgtggccg gcctgctgcc cagcagagat tttctggccg gactggcctt 2700 ccgggtgttc cactgcaccc agtacatcag acacggcagc aagcccatgt acacccctga 2760 gcccgacatc tgccacgagc tgctgggaca tgtgcccctg ttcagcgaca gaagcttcgc 2820 ccagttcagc caggaaatcg gcctggcctc tctgggcgct cccgacgagt atatcgagaa 2880 gctggccacc atctactggt tcaccgtgga attcggcctg tgcaagcagg gcgacagcat 2940 caaggcctat ggcgccggac tcctgtccag cttcggcgag ctgcagtact gtctgagcga 3000 gaagcccaag ctgctgcccc tggaactgga aaagaccgcc atccagaact acaccgtgac 3060 cgagttccag cccctgtact acgtggccga gagcttcaac gacgccaaag aaaaagtgcg 3120 gaacttcgcc gccaccatcc ctcggccctt cagcgtcaga tacgacccct acacccagcg 3180 gatcgaggtg ctggacaaca cacagcagct gaaaattctg gccgactcca tcaacagcga 3240 gatcggcatc ctgtgcagcg ccctgcagaa aatcaagtga actagtctgt gccttctagt 3300 tgccagccat ctgttgtttg cccctccccc gtgccttcct tgaccctgga aggtgccact 3360 cccactgtcc tttcctaata aaatgaggaa attgcatcgc attgtctgag taggtgtcat 3420 tctattctgg ggggtggggt ggggcaggac agcaaggggg aggattggga agacaatagc 3480 aggcatgctg gggatgcggt gggctctata ccggtccagg ggtgagtgaa ggtttggaag 3540 agtgtagcag aataagaaac catgagtccc ctccctgaga agccctgagc ccccttgacg 3600 acacacatcc ctcgaggctc agcttcatca tctgtaaaag gtgctgaaac tgaccatcca 3660 agctgccgaa aaagattgtg tggggataat tcaaaactag aggaagatgc agaatttcta 3720 catcgtggcg atgtcaggct aagagttgcc atcgtggctg tccatcgatt ttattggaat 3780 catatgttta tttgagggtg tcttggatat tacaaataaa ttgttggagc atcaggcata 3840 tttggtaatt ctgtctaagg ctccctgccc cttgttaatt ggcagctcag ttattcatcc 3900 agggcaaaca ttctgcttac tattcctgag agctttcctc atcctctaga ttggcagggg 3960 aattgcagtt gcctgagcag cctcccctct gccataccaa cagagcttca ccatcgaggc 4020 ttgcagagtg gacaggggcc tcagggaccc ctgatcccag ctttctcatt ggacagaagg 4080 aggagactgg ggctggagag ggacctgggc ccccactaag gccacagcag agccaggact 4140 ttagctgtgc tgactgcagc ctggcttgcc tccactgccc tcctttgcct caagagcaag 4200 ggagcctcag agtggaggaa gcagcccctg gccttgcctc ccacctcccc tcccctttgc 4260 tgttttcctg ggacagtggg agctggctta gattgccctg gggcccccag gaccctggca 4320 ttttaacccc tcaggggcag gaaggcagcc tgagatacag aagagtccat cacctgctgt 4380 atgccacaca ccatccccac agtcgacatt taaattagga acccctagtg atggagttgg 4440 ccactccctc tctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc 4500 gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca 4560 a 4561 <210> 7 <211> 204 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Construct <400> 7 gcgagaactt gtgcctcccc gtgttcctga cctttgaccc tctgtcctac ttagactaat 60 attgactttg ggtactgcaa acaggaaatg ggggagggat tcgatgcgag aacttgtgcc 120 tccccgtgtt cctgaccttt gaccctctgt cctacttaga ctaatattga ctttgggtac 180 tgcaaacagg aaatggggga ggga 204 <210> 8 <211> 330 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Construct <400> 8 ggccccaggt taatttttaa aaagcagtca aaggtcaaag tggcccttgg cagcatttac 60 tctctctatt gactttggtt aataatctca ggagcacaaa cattcctgga ggcaggagaa 120 gaaatcaaca tcctggactt atcctctggg cctctcccca ccttcgatgg ccccaggtta 180 atttttaaaa agcagtcaaa ggtcaaagtg gcccttggca gcatttactc tctctattga 240 ctttggttaa taatctcagg agcacaaaca ttcctggagg caggagaaga aatcaacatc 300 ctggacttat cctctgggcc tctccccacc 330 <210> 9 <211> 377 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Construct <400> 9 gttcctagat tacattacac attctgcaag catagcacag gtcaaagttc aactttaatt 60 actttcattt tcttgtatcc tcacagccta gaaaataacc tgcgttacag catccactca 120 gtatcccttg agcatgaggt gacactactt aacataggga cgagatggta ctttgtgtct 180 cctgctctgt cagcagggca ctgtacttgc tgataccagg gaatattgat ttgtaaatac 240 catcattccg aacgtgtttg ccttggccag ttttccatgt acatgcagaa agaagtttgg 300 gactgatcaa tacagtcctc tgcctttaaa gcaataggaa aaggccaact tgtctacgtt 360 tagtatgtgg ctgtaga 377 <210> 10 <211> 156 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Construct <400> 10 ccatcagatc ctgcccaagg tcttacataa gaggactctt ggactcccag caatgtcaac 60 gaccgacctt gaggcctact tcaaagactg tgtgtttaag gactgggagg agctggggga 120 ggagattagg ttaaaggtct ttgtattagg aggctg 156 <210> 11 <211> 71 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Construct <400> 11 ggggaggctg ctggtgaata ttaaccaagg tcaccccagt tatcggagga gcaaacaggg 60 gctaagtcca c 71 <210> 12 <211> 869 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Construct <400> 12 ctcaattgga tgacactagt catcacattt aaaagcatct caggtaacta tattttgaat 60 tttttaaaaa agtaactata atagttatta ttaaaatagc aaagattgac catttccaag 120 agccatatag accagcaccg accactattc taaactattt atgtatgtaa atattagctt 180 ttaaaattct caaaatagtt gctgagttgg gaaccactat tatttctatc gattcagcag 240 ccgtaagtct aggacaggct taaattgttt tcactggtgt aaattgcaga aagatgatct 300 aagtaatttg gcatttattt taataggttt gaaaaacaca tgccatttta caaataagac 360 ttatatttgt ccttttgttt ttcagcctac catgagaata agagaaagaa aatgaagatc 420 aaaagcttat tcatctgttt ttctttttcg ttggtgtaaa gccaacaccc tgtctaaaaa 480 acataaattt ctttaatcat tttgcctctt ttctctgtgc ttcaattaat aaaaaatgga 540 aagaatctaa tagagtggta cagcactgtt atttttcaaa gatgtgttgc tatcctgaaa 600 attctgtagg ttctgtggaa gttccagtgt tctctcttat tccacttcgg tagaggattt 660 ctagtttctt gtgggctaat taaataaatc attaatactc ttctaagtta tggattataa 720 acattcaaaa taatattttg acattatgat aattctgaat aaaagaacaa aaaccatggt 780 ataggtaagg aatataaaac atggctttta ccttagaaaa aacaattcta aaattcatat 840 ggaatcaaaa aagagcctgc aggtaccct 869 <210> 13 <211> 1302 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Construct <400> 13 ctcaattgga tgacactagt catcacattt aaaagcatct caggtaacta tattttgaat 60 tttttaaaaa agtaactata atagttatta ttaaaatagc aaagattgac catttccaag 120 agccatatag accagcaccg accactattc taaactattt atgtatgtaa atattagctt 180 ttaaaattct caaaatagtt gctgagttgg gaaccactat tatttctatc tactgtttta 240 attaaaatta tctctaaggc atgtgaactg gctgtcttgg ttttcatctg tacttcatct 300 gctacctctg tgacctgaaa catatttata attccattaa gctgtgcata tgatagattt 360 atcatatgta ttttccttaa aggatttttg taagaactaa ttgaattgat acctgtaaag 420 tctttatcac actacccaat aaataataaa tctctttgtt cagctctctg tttctataaa 480 tatgtaccag ttttattgtt tttagtggta gtgattttat tctctttcta tatatataca 540 cacacatgtg tgcattcata aatatataca atttttatga ataaaaaatt attagcaatc 600 aatattgaaa accactgatt tttgtttatg tgagcaaaca gcagattaaa aggaattcct 660 gcagattcag cagccgtaag tctaggacag gcttaaattg ttttcactgg tgtaaattgc 720 agaaagatga tctaagtaat ttggcattta ttttaatagg tttgaaaaac acatgccatt 780 ttacaaataa gacttatatt tgtccttttg tttttcagcc taccatgaga ataagagaaa 840 gaaaatgaag atcaaaagct tattcatctg tttttctttt tcgttggtgt aaagccaaca 900 ccctgtctaa aaaacataaa tttctttaat cattttgcct cttttctctg tgcttcaatt 960 aataaaaaat ggaaagaatc taatagagtg gtacagcact gttatttttc aaagatgtgt 1020 tgctatcctg aaaattctgt aggttctgtg gaagttccag tgttctctct tattccactt 1080 cggtagagga tttctagttt cttgtgggct aattaaataa atcattaata ctcttctaag 1140 ttatggatta taaacattca aaataatatt ttgacattat gataattctg aataaaagaa 1200 caaaaaccat ggtataggta aggaatataa aacatggctt ttaccttaga aaaaacaatt 1260 ctaaaattca tatggaatca aaaaagagcc tgcaggtacc ct 1302 <210> 14 <211> 1359 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Construct <400> 14 atgagcacag ccgtgctgga aaaccccggc ctgggcagaa agctgagcga cttcggccag 60 gaaaccagct acatcgagga caactgcaac cagaacggcg ccatcagcct gatcttcagc 120 ctgaaagaag aagtgggcgc cctggccaag gtgctgcggc tgttcgaaga gaacgacgtg 180 aacctgaccc acatcgagag ccggcccagc agactgaaga aggacgagta cgagttcttc 240 acccacctgg acaagcggag cctgcccgcc ctgaccaaca tcatcaagat cctgcggcac 300 gacatcggcg ccaccgtgca cgagctgagc cgggacaaga aaaaggacac cgtgccctgg 360 ttccccagaa ccatccagga actggacaga ttcgccaacc agatcctgtc ctacggcgcc 420 gagctggatg ccgaccaccc tggcttcaag gaccccgtgt accgggccag acggaagcag 480 ttcgccgata tcgcctacaa ctaccggcac ggccagccca tccccagagt cgagtacatg 540 gaagagggca agaaaacctg gggcaccgtg ttcaagaccc tgaagtccct gtacaagacc 600 cacgcctgct acgagtacaa ccacatcttc ccactgctcg agaagtactg cggcttccac 660 gaggacaata tccctcagct cgaggacgtg tcccagtttc tgcagacctg caccggcttc 720 agactcaggc ctgtggccgg cctgctgagc agcagagatt ttctgggcgg actggccttc 780 cgggtgttcc actgcaccca gtacatcaga cacggcagca agcccatgta cacccctgag 840 cccgacatct gccacgagct gctgggacat gtgcccctgt tcagcgacag aagcttcgcc 900 cagttcagcc aggaaatcgg cctggcctct ctgggcgctc ccgacgagta tatcgagaag 960 ctggccacca tctactggtt caccgtggaa ttcggcctgt gcaagcaggg cgacagcatc 1020 aaggcctatg gcgccggact cctgtccagc ttcggcgagc tgcagtactg tctgagcgag 1080 aagcccaagc tgctgcccct ggaactggaa aagaccgcca tccagaacta caccgtgacc 1140 gagttccagc ccctgtacta cgtggccgag agcttcaacg acgccaaaga aaaagtgcgg 1200 aacttcgccg ccaccatccc tcggcccttc agcgtcagat acgaccccta cacccagcgg 1260 atcgaggtgc tggacaacac acagcagctg aaaattctgg ccgactccat caacagcgag 1320 atcggcatcc tgtgcagcgc cctgcagaaa atcaagtga 1359 <210> 15 <211> 1069 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Construct <400> 15 agtcgctgcg cgctgccttc gccccgtgcc ccgctccgcc gccgcctcgc gccgcccgcc 60 ccggctctga ctgaccgcgt tactcccaca ggtgagcggg cgggacggcc cttctcctcc 120 gggctgtaat tagcgcttgg tttattgacg gcttgtttct tttctgtggc tgcgtgaaag 180 ccttgagggg ctccgggaag gccctttgtg cggggggagc ggctcggggg gtgcgtgcgt 240 gtgtgtgtgc gtggggagcg ccgcgtgcgg ctccgcgctg cccggcggct gtgagcgctg 300 cgggcgcggc gcggggcttt gtgcgctccg cagtgtgcgc gaggggagcg gggccggggg 360 cggtgccccg cggtgcgggg ggggctgcga ggggaacaaa ggctgcgtgc ggggtgtgtg 420 cgtggggggg tgagcagggg gtgtgggcgc gtcggtcggg ctgcaacccc ccctgcaccc 480 ccctccccga gttgctgagc acggcccggc ttcgggtgcg gggctccgta cggggcgtgg 540 cgcggggctc gccgtgccgg gcggggggtg gcggcaggtg ggggtgccgg gcggggcggg 600 gccgcctcgg gccggggagg gctcggggga ggggcgcggc ggcccccgga gcgccggcgg 660 ctgtcgaggc gcggcgagcc gcagccattg ccttttttgg taatcgtgcg agagggcgca 720 gggacttcct ttgtcccaaa tctgtgcgga gccgaaatct gggaggcgcc gccgcacccc 780 ctctagcggg cgcggggcga agcggtgcgg cgccggcagg aaggaattgg gcggggaggg 840 ccttcgtgcg tcgccgcgcc gccgtcccct tctccctctc cagcctcggg gctgtccgcg 900 gggggacggc tgccttcggg ggggacgggg cagggcgggg ttcggcttct ggcgtgtgac 960 cggcggctct agagcctctg ctaaccttgt tcttgccttc ttctttttcc tacagctcct 1020 gggcaacgtg ctggttattg tgctgtctca tcattttggc aaagaattc 1069 <210> 16 <211> 901 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Construct <400> 16 ccaggggtga gtgaaggttt ggaagagtgt agcagaataa gaaaccatga gtcccctccc 60 tgagaagccc tgagccccct tgacgacaca catccctcga ggctcagctt catcatctgt 120 aaaaggtgct gaaactgacc atccaagctg ccgaaaaaga ttgtgtgggg ataattcaaa 180 actagaggaa gatgcagaat ttctacatcg tggcgatgtc aggctaagag ttgccatcgt 240 ggctgtccat cgattttatt ggaatcatat gtttatttga gggtgtcttg gatattacaa 300 ataaattgtt ggagcatcag gcatatttgg taattctgtc taaggctccc tgccccttgt 360 taattggcag ctcagttatt catccagggc aaacattctg cttactattc ctgagagctt 420 tcctcatcct ctagattggc aggggaattg cagttgcctg agcagcctcc cctctgccat 480 accaacagag cttcaccatc gaggcttgca gagtggacag gggcctcagg gacccctgat 540 cccagctttc tcattggaca gaaggaggag actggggctg gagagggacc tgggccccca 600 ctaaggccac agcagagcca ggactttagc tgtgctgact gcagcctggc ttgcctccac 660 tgccctcctt tgcctcaaga gcaagggagc ctcagagtgg aggaagcagc ccctggcctt 720 gcctcccacc tcccctcccc tttgctgttt tcctgggaca gtgggagctg gcttagattg 780 ccctggggcc cccaggaccc tggcatttta acccctcagg ggcaggaagg cagcctgaga 840 tacagaagag tccatcacct gctgtatgcc acacaccatc cccacagtcg acatttaaat 900 t 901 <210> 17 <211> 78 <212> DNA <213> Artificial Sequence <220> <223> Synthetic Construct <400> 17 cactccctct ctgcgcgctc gctcgctcac tgaggccggg cgaccaaagg tcgcccacgc 60 ccgggctttg cccgggcg 78 <210> 18 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic Construct <400> 18 Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 1 5 10 15 Tyr Lys Asp Asp Asp Asp Lys 20