LISTA DE SECUENCIAS <110> Sanofi <120> Conjugado de insulina <130> DE2018/057 <150> EP 18 306 657.0 <151> 2018-12-11 <150> EP 18 306 658.8 <151> 2018-12-11 <150> EP 18 306 659.6 <151> 2018-12-11 <160> 105 <170> BiSSAP 1.3.6 <210> 1 <211> 21 <212> PRT <213> Homo sapiens <220> <223> Cadena A <400> 1 Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 1 5 10 15 Glu Asn Tyr Cys Asn 20 <210> 2 <211> 30 <212> PRT <213> Homo sapiens <220> <223> Cadena B <400> 2 Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr 20 25 30 <210> 3 <211> 21 <212> PRT <213> Secuencia Artificial <220> <223> Cadena A <400> 3 Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 1 5 10 15 Glu Asn Tyr Cys Asn 20 <210> 4 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 4 Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys 20 25 <210> 5 <211> 21 <212> PRT <213> Secuencia Artificial <220> <223> Cadena A <400> 5 Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 1 5 10 15 Glu Asn Tyr Cys Asn 20 <210> 6 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 6 Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Leu 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys 20 25 <210> 7 <211> 21 <212> PRT <213> Secuencia Artificial <220> <223> Cadena A <400> 7 Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 1 5 10 15 Glu Asn Tyr Cys Gly 20 <210> 8 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 8 Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Trp 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys 20 25 <210> 9 <211> 21 <212> PRT <213> Secuencia Artificial <220> <223> Cadena A <400> 9 Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 1 5 10 15 Glu Asn Tyr Cys Asn 20 <210> 10 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 10 Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu His 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys 20 25 <210> 11 <211> 21 <212> PRT <213> Secuencia Artificial <220> <223> Cadena A <400> 11 Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 1 5 10 15 Glu Asn Tyr Cys Asn 20 <210> 12 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 12 Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Val 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys 20 25 <210> 13 <211> 21 <212> PRT <213> Secuencia Artificial <220> <223> Cadena A <400> 13 Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 1 5 10 15 Glu Asn Tyr Cys Asn 20 <210> 14 <211> 30 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 14 Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Ala Tyr Thr Pro Lys Thr 20 25 30 <210> 15 <211> 21 <212> PRT <213> Secuencia Artificial <220> <223> Cadena A <400> 15 Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 1 5 10 15 Glu Asn Tyr Cys Asn 20 <210> 16 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 16 Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Ala Tyr Thr Pro Lys 20 25 <210> 17 <211> 21 <212> PRT <213> Secuencia Artificial <220> <223> Cadena A <400> 17 Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 1 5 10 15 Glu Asn Tyr Cys Asn 20 <210> 18 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 18 Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Glu Tyr Thr Pro Lys 20 25 <210> 19 <211> 21 <212> PRT <213> Secuencia Artificial <220> <223> Cadena A <400> 19 Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 1 5 10 15 Glu Asn Tyr Cys Asn 20 <210> 20 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 20 Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe His Tyr Thr Pro Lys 20 25 <210> 21 <211> 21 <212> PRT <213> Secuencia Artificial <220> <223> Cadena A <400> 21 Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 1 5 10 15 Glu Asn Tyr Cys Asn 20 <210> 22 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 22 Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Leu Tyr Thr Pro Lys 20 25 <210> 23 <211> 21 <212> PRT <213> Secuencia Artificial <220> <223> Cadena A <400> 23 Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 1 5 10 15 Glu Asn Tyr Cys Asn 20 <210> 24 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 24 Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Val Tyr Thr Pro Lys 20 25 <210> 25 <211> 21 <212> PRT <213> Secuencia Artificial <220> <223> Cadena A <400> 25 Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 1 5 10 15 Glu Asn Tyr Cys Asn 20 <210> 26 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 26 Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu His 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe His Tyr Thr Pro Lys 20 25 <210> 27 <211> 21 <212> PRT <213> Secuencia Artificial <220> <223> Cadena A <400> 27 Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 1 5 10 15 Glu Asn Tyr Cys Gly 20 <210> 28 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 28 Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Trp 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe His Tyr Thr Pro Lys 20 25 <210> 29 <211> 21 <212> PRT <213> Secuencia Artificial <220> <223> Cadena A <400> 29 Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 1 5 10 15 Glu Asn Tyr Cys Gly 20 <210> 30 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 30 Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Trp 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Trp Tyr Thr Pro Lys 20 25 <210> 31 <211> 21 <212> PRT <213> Secuencia Artificial <220> <223> Cadena A <400> 31 Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 1 5 10 15 Glu Asn Tyr Cys Asn 20 <210> 32 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 32 Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu His 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys 20 25 <210> 33 <211> 21 <212> PRT <213> Secuencia Artificial <220> <223> Cadena A <400> 33 Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 1 5 10 15 Glu Asn Tyr Cys Gly 20 <210> 34 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 34 Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Trp 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys 20 25 <210> 35 <211> 21 <212> PRT <213> Secuencia Artificial <220> <223> Cadena A <400> 35 Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 1 5 10 15 Glu Asn Tyr Cys Asn 20 <210> 36 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 36 Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Ile 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys 20 25 <210> 37 <211> 21 <212> PRT <213> Secuencia Artificial <220> <223> Cadena A <400> 37 Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 1 5 10 15 Glu Asn Tyr Cys Asn 20 <210> 38 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 38 Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Val 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys 20 25 <210> 39 <211> 21 <212> PRT <213> Secuencia Artificial <220> <223> Cadena A <400> 39 Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 1 5 10 15 Glu Asn Tyr Cys Asn 20 <210> 40 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 40 Phe Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Val 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys 20 25 <210> 41 <211> 21 <212> PRT <213> Secuencia Artificial <220> <223> Cadena A <400> 41 Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 1 5 10 15 Glu Asn Tyr Cys Asn 20 <210> 42 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 42 Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe His Tyr Thr Pro Lys 20 25 <210> 43 <211> 21 <212> PRT <213> Secuencia Artificial <220> <223> Cadena A <400> 43 Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 1 5 10 15 Glu Asn Tyr Cys Asn 20 <210> 44 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 44 Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Ile Tyr Thr Pro Lys 20 25 <210> 45 <211> 21 <212> PRT <213> Secuencia Artificial <220> <223> Cadena A <400> 45 Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 1 5 10 15 Glu Asn Tyr Cys Gly 20 <210> 46 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 46 Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Trp Tyr Thr Pro Lys 20 25 <210> 47 <211> 21 <212> PRT <213> Secuencia Artificial <220> <223> Cadena A <400> 47 Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 1 5 10 15 Glu Asn Tyr Cys Asn 20 <210> 48 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 48 Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Val Tyr Thr Pro Lys 20 25 <210> 49 <211> 21 <212> PRT <213> Secuencia Artificial <220> <223> Cadena A <400> 49 Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 1 5 10 15 Glu Asn Tyr Cys Gly 20 <210> 50 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 50 Phe Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Val Tyr Thr Pro Lys 20 25 <210> 51 <211> 21 <212> PRT <213> Secuencia Artificial <220> <223> Cadena A <400> 51 Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 1 5 10 15 Glu Asn Tyr Cys Asn 20 <210> 52 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 52 Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Glu 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe His Tyr Thr Pro Lys 20 25 <210> 53 <211> 21 <212> PRT <213> Secuencia Artificial <220> <223> Cadena A <400> 53 Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 1 5 10 15 Glu Asn Tyr Cys Asn 20 <210> 54 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 54 Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu His 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Ala Tyr Thr Pro Lys 20 25 <210> 55 <211> 21 <212> PRT <213> Secuencia Artificial <220> <223> Cadena A <400> 55 Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 1 5 10 15 Glu Asn Tyr Cys Asn 20 <210> 56 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 56 Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu His 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe His Tyr Thr Pro Lys 20 25 <210> 57 <211> 21 <212> PRT <213> Secuencia Artificial <220> <223> Cadena A <400> 57 Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 1 5 10 15 Glu Asn Tyr Cys Asn 20 <210> 58 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 58 Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Ile 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Ile Tyr Thr Pro Lys 20 25 <210> 59 <211> 21 <212> PRT <213> Secuencia Artificial <220> <223> Cadena A <400> 59 Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 1 5 10 15 Glu Asn Tyr Cys Asn 20 <210> 60 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 60 Phe Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Ile 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Ile Tyr Thr Pro Lys 20 25 <210> 61 <211> 21 <212> PRT <213> Secuencia Artificial <220> <223> Cadena A <400> 61 Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 1 5 10 15 Glu Asn Tyr Cys Gly 20 <210> 62 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 62 Phe Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Ile 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Trp Tyr Thr Pro Lys 20 25 <210> 63 <211> 21 <212> PRT <213> Secuencia Artificial <220> <223> Cadena A <400> 63 Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 1 5 10 15 Glu Asn Tyr Cys Asn 20 <210> 64 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 64 Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Ile 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Val Tyr Thr Pro Lys 20 25 <210> 65 <211> 21 <212> PRT <213> Secuencia Artificial <220> <223> Cadena A <400> 65 Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 1 5 10 15 Glu Asn Tyr Cys Gly 20 <210> 66 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 66 Phe Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Ile 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Val Tyr Thr Pro Lys 20 25 <210> 67 <211> 21 <212> PRT <213> Secuencia Artificial <220> <223> Cadena A <400> 67 Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 1 5 10 15 Glu Asn Tyr Cys Asn 20 <210> 68 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 68 Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Leu 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Ala Tyr Thr Pro Lys 20 25 <210> 69 <211> 21 <212> PRT <213> Secuencia Artificial <220> <223> Cadena A <400> 69 Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 1 5 10 15 Glu Asn Tyr Cys Asn 20 <210> 70 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 70 Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Val 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Ile Tyr Thr Pro Lys 20 25 <210> 71 <211> 21 <212> PRT <213> Secuencia Artificial <220> <223> Cadena A <400> 71 Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 1 5 10 15 Glu Asn Tyr Cys Gly 20 <210> 72 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 72 Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Val 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Trp Tyr Thr Pro Lys 20 25 <210> 73 <211> 21 <212> PRT <213> Secuencia Artificial <220> <223> Cadena A <400> 73 Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 1 5 10 15 Glu Asn Tyr Cys Gly 20 <210> 74 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 74 Phe Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Val 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Trp Tyr Thr Pro Lys 20 25 <210> 75 <211> 21 <212> PRT <213> Secuencia Artificial <220> <223> Cadena A <400> 75 Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 1 5 10 15 Glu Asn Tyr Cys Asn 20 <210> 76 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 76 Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Val 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Val Tyr Thr Pro Lys 20 25 <210> 77 <211> 21 <212> PRT <213> Secuencia Artificial <220> <223> Cadena A <400> 77 Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 1 5 10 15 Glu Asn Tyr Cys Asn 20 <210> 78 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 78 Phe Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Val 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Val Tyr Thr Pro Lys 20 25 <210> 79 <211> 21 <212> PRT <213> Secuencia Artificial <220> <223> Cadena A <400> 79 Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 1 5 10 15 Glu Asn Tyr Cys Gly 20 <210> 80 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 80 Phe Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Val 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Val Tyr Thr Pro Lys 20 25 <210> 81 <211> 21 <212> PRT <213> Bos <220> <223> Cadena A <400> 81 Gly Ile Val Glu Gln Cys Cys Ala Ser Val Cys Ser Leu Tyr Gln Leu 1 5 10 15 Glu Asn Tyr Cys Asn 20 <210> 82 <211> 30 <212> PRT <213> Bos <220> <223> Cadena B <400> 82 Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Ala 20 25 30 <210> 83 <211> 21 <212> PRT <213> Sus <220> <223> Cadena A <400> 83 Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 1 5 10 15 Glu Asn Tyr Cys Asn 20 <210> 84 <211> 30 <212> PRT <213> Sus <220> <223> Cadena B <400> 84 Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Ala 20 25 30 <210> 85 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 85 Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Leu Tyr Thr Pro Lys 20 25 <210> 86 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 86 Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Val Tyr Thr Pro Lys 20 25 <210> 87 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 87 Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Ile Tyr Thr Pro Lys 20 25 <210> 88 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 88 Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Val Tyr Thr Pro Lys 20 25 <210> 89 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 89 Phe Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Val Tyr Thr Pro Lys 20 25 <210> 90 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 90 Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Ile 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Ile Tyr Thr Pro Lys 20 25 <210> 91 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 91 Phe Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Ile 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Ile Tyr Thr Pro Lys 20 25 <210> 92 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 92 Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Ile 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Val Tyr Thr Pro Lys 20 25 <210> 93 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 93 Phe Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Ile 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Val Tyr Thr Pro Lys 20 25 <210> 94 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 94 Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Val 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Ile Tyr Thr Pro Lys 20 25 <210> 95 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 95 Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Val 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Val Tyr Thr Pro Lys 20 25 <210> 96 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 96 Phe Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Val 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Val Tyr Thr Pro Lys 20 25 <210> 97 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> Cadena B <400> 97 Phe Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Val 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Val Tyr Thr Pro Lys 20 25 <210> 98 <211> 44 <212> PRT <213> Secuencia Artificial <220> <223> Lixisenatida <400> 98 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 1 5 10 15 Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Ser Lys Lys Lys Lys Lys Lys 35 40 <210> 99 <211> 39 <212> PRT <213> Secuencia Artificial <220> <223> Exenatida <400> 99 His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 1 5 10 15 Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 20 25 30 Ser Gly Ala Pro Pro Pro Ser 35 <210> 100 <211> 31 <212> PRT <213> Secuencia Artificial <220> <223> Semaglutida <220> <221> MOD_RES <222> 2 <223> Aib <400> 100 His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15 Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 20 25 30 <210> 101 <211> 31 <212> PRT <213> Secuencia Artificial <220> <223> Dulaglutida <400> 101 His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15 Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 20 25 30 <210> 102 <211> 21 <212> PRT <213> Homo sapiens <220> <223> insulina humana, Cadena A <400> 102 Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 1 5 10 15 Glu Asn Tyr Cys Asn 20 <210> 103 <211> 30 <212> PRT <213> Homo sapiens <220> <223> insulina humana, Cadena B <400> 103 Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr 20 25 30 <210> 104 <211> 21 <212> PRT <213> Secuencia Artificial <220> <223> análogo 1 de insulina, Cadena A <400> 104 Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 1 5 10 15 Glu Asn Tyr Cys Asn 20 <210> 105 <211> 29 <212> PRT <213> Secuencia Artificial <220> <223> análogo 1 de insulina, Cadena B <400> 105 Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu His 1 5 10 15 Leu Val Cys Gly Glu Arg Gly Phe His Tyr Thr Pro Lys 20 25