LISTADO DE SECUENCIAS <110> NOVARTIS AG <120> ANTICUERPOS ANTI-PMEL17 Y CONJUGADOS DE LOS MISMOS <130> PAT058359-WO-PCT <140> <141> <150> 62/803,110 <151> 2019-02-08 <150> 62/783,565 <151> 2018-12-21 <160> 282 <170> PatentIn version 3.5 <210> 1 <211> 10 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 1 Gly Gly Thr Phe Ser Asp Tyr Ala Ile Thr 1 5 10 <210> 2 <211> 17 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 2 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 3 <211> 17 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 3 Glu Gly Gly Leu Leu Thr Asp Ile Ser Tyr Ser Arg Tyr Trp Phe Ala 1 5 10 15 Tyr <210> 4 <211> 5 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 4 Asp Tyr Ala Ile Thr 1 5 <210> 5 <211> 7 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 5 Gly Gly Thr Phe Ser Asp Tyr 1 5 <210> 6 <211> 6 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 6 Ile Pro Ile Phe Gly Thr 1 5 <210> 7 <211> 8 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 7 Gly Gly Thr Phe Ser Asp Tyr Ala 1 5 <210> 8 <211> 8 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 8 Ile Ile Pro Ile Phe Gly Thr Ala 1 5 <210> 9 <211> 19 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 9 Ala Arg Glu Gly Gly Leu Leu Thr Asp Ile Ser Tyr Ser Arg Tyr Trp 1 5 10 15 Phe Ala Tyr <210> 10 <211> 126 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 10 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asp Tyr 20 25 30 Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Gly Gly Leu Leu Thr Asp Ile Ser Tyr Ser Arg Tyr Trp 100 105 110 Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 11 <211> 378 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético" <400> 11 caggtgcaat tggtgcagag cggtgccgaa gtgaaaaaac cgggcagcag cgtgaaagtt 60 agctgcaaag catccggagg gacgttttct gactacgcta tcacttgggt gcgccaggcc 120 ccgggccagg gcctcgagtg gatgggcggt atcatcccga tcttcggcac tgcgaactac 180 gcccagaaat ttcagggccg ggtgaccatt accgccgatg aaagcaccag caccgcctat 240 atggaactga gcagcctgcg cagcgaagat acggccgtgt attattgcgc gcgtgaaggt 300 ggtctgctga ctgacatctc ttactctcgt tactggttcg cttactgggg ccaaggcacc 360 ctggtgactg ttagctca 378 <210> 12 <211> 456 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 12 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asp Tyr 20 25 30 Ala Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Gly Gly Leu Leu Thr Asp Ile Ser Tyr Ser Arg Tyr Trp 100 105 110 Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 115 120 125 Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 130 135 140 Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 145 150 155 160 Cys Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 165 170 175 His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 180 185 190 Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 195 200 205 Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 210 215 220 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 225 230 235 240 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 245 250 255 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 260 265 270 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 275 280 285 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 290 295 300 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 305 310 315 320 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 325 330 335 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 340 345 350 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 355 360 365 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Cys 370 375 380 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 385 390 395 400 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 405 410 415 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 420 425 430 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 435 440 445 Ser Leu Ser Leu Ser Pro Gly Lys 450 455 <210> 13 <211> 1368 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético" <400> 13 caggtgcaat tggtgcagag cggtgccgaa gtgaaaaaac cgggcagcag cgtgaaagtt 60 agctgcaaag catccggagg gacgttttct gactacgcta tcacttgggt gcgccaggcc 120 ccgggccagg gcctcgagtg gatgggcggt atcatcccga tcttcggcac tgcgaactac 180 gcccagaaat ttcagggccg ggtgaccatt accgccgatg aaagcaccag caccgcctat 240 atggaactga gcagcctgcg cagcgaagat acggccgtgt attattgcgc gcgtgaaggt 300 ggtctgctga ctgacatctc ttactctcgt tactggttcg cttactgggg ccaaggcacc 360 ctggtgactg ttagctcagc tagcaccaag ggcccaagtg tgtttcccct ggcccccagc 420 agcaagtcta cttccggcgg aactgctgcc ctgggttgcc tggtgaagga ctacttcccc 480 tgtcccgtga cagtgtcctg gaactctggg gctctgactt ccggcgtgca caccttcccc 540 gccgtgctgc agagcagcgg cctgtacagc ctgagcagcg tggtgacagt gccctccagc 600 tctctgggaa cccagaccta tatctgcaac gtgaaccaca agcccagcaa caccaaggtg 660 gacaagagag tggagcccaa gagctgcgac aagacccaca cctgcccccc ctgcccagct 720 ccagaactgc tgggagggcc ttccgtgttc ctgttccccc ccaagcccaa ggacaccctg 780 atgatcagca ggacccccga ggtgacctgc gtggtggtgg acgtgtccca cgaggaccca 840 gaggtgaagt tcaactggta cgtggacggc gtggaggtgc acaacgccaa gaccaagccc 900 agagaggagc agtacaacag cacctacagg gtggtgtccg tgctgaccgt gctgcaccag 960 gactggctga acggcaaaga atacaagtgc aaagtctcca acaaggccct gccagcccca 1020 atcgaaaaga caatcagcaa ggccaagggc cagccacggg agccccaggt gtacaccctg 1080 ccccccagcc gggaggagat gaccaagaac caggtgtccc tgacctgtct ggtgaagggc 1140 ttctacccct gtgatatcgc cgtggagtgg gagagcaacg gccagcccga gaacaactac 1200 aagaccaccc ccccagtgct ggacagcgac ggcagcttct tcctgtacag caagctgacc 1260 gtggacaagt ccaggtggca gcagggcaac gtgttcagct gcagcgtgat gcacgaggcc 1320 ctgcacaacc actacaccca gaagtccctg agcctgagcc ccggcaag 1368 <210> 14 <211> 11 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 14 Ser Gly Asp Ala Leu Arg Asp Lys Phe Val Tyr 1 5 10 <210> 15 <211> 7 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 15 Asp Asp Asn Asn Arg Pro Ser 1 5 <210> 16 <211> 11 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 16 Gln Ser Trp Asp His Ser Tyr Ser Leu Val Val 1 5 10 <210> 17 <211> 7 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 17 Asp Ala Leu Arg Asp Lys Phe 1 5 <210> 18 <211> 3 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 18 Asp Asp Asn 1 <210> 19 <211> 8 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 19 Trp Asp His Ser Tyr Ser Leu Val 1 5 <210> 20 <211> 6 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 20 Ala Leu Arg Asp Lys Phe 1 5 <210> 21 <211> 108 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 21 Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 1 5 10 15 Thr Ala Ser Ile Thr Cys Ser Gly Asp Ala Leu Arg Asp Lys Phe Val 20 25 30 Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45 Asp Asp Asn Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 50 55 60 Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 65 70 75 80 Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Trp Asp His Ser Tyr Ser Leu 85 90 95 Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 <210> 22 <211> 324 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 22 gatatcgaac tgacccagcc gccgagcgtg agcgtgagcc cgggccagac cgcgagcatt 60 acctgtagcg gcgatgctct gcgtgacaaa ttcgtttact ggtaccagca gaaaccgggc 120 caggcgccgg tgctggtgat ctacgacgac aacaaccgtc cgagcggcat cccggaacgt 180 tttagcggat ccaacagcgg caacaccgcg accctgacca ttagcggcac ccaggcggaa 240 gacgaagcgg attattactg ccagtcttgg gaccattctt actctctggt tgtgtttggc 300 ggcggcacga agttaactgt cctg 324 <210> 23 <211> 214 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 23 Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 1 5 10 15 Thr Ala Ser Ile Thr Cys Ser Gly Asp Ala Leu Arg Asp Lys Phe Val 20 25 30 Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45 Asp Asp Asn Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 50 55 60 Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 65 70 75 80 Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Trp Asp His Ser Tyr Ser Leu 85 90 95 Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 100 105 110 Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 115 120 125 Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 130 135 140 Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 145 150 155 160 Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 165 170 175 Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 180 185 190 Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 195 200 205 Ala Pro Thr Glu Cys Ser 210 <210> 24 <211> 642 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 24 gatatcgaac tgacccagcc gccgagcgtg agcgtgagcc cgggccagac cgcgagcatt 60 acctgtagcg gcgatgctct gcgtgacaaa ttcgtttact ggtaccagca gaaaccgggc 120 caggcgccgg tgctggtgat ctacgacgac aacaaccgtc cgagcggcat cccggaacgt 180 tttagcggat ccaacagcgg caacaccgcg accctgacca ttagcggcac ccaggcggaa 240 gacgaagcgg attattactg ccagtcttgg gaccattctt actctctggt tgtgtttggc 300 ggcggcacga agttaactgt cctgggacaa cctaaggccg ctccctccgt gaccctgttc 360 ccccccagct ccgaggaact gcaggccaac aaggccaccc tggtgtgcct gatcagcgac 420 ttctaccctg gcgccgtgac cgtggcctgg aaggccgaca gcagccccgt gaaggccggc 480 gtggagacaa ccacccccag caagcagagc aacaacaagt acgccgccag cagctacctg 540 agcctgaccc ccgagcagtg gaagagccac agaagctaca gctgccaggt cacccacgag 600 ggcagcaccg tggagaaaac cgtggccccc accgagtgca gc 642 <210> 25 <211> 108 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 25 Ser Tyr Glu Leu Thr Gln Pro Leu Ser Val Ser Val Ala Leu Gly Gln 1 5 10 15 Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Arg Asp Lys Phe Val 20 25 30 Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45 Asp Asp Asn Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 50 55 60 Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Ala Gln Ala Gly 65 70 75 80 Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Trp Asp His Ser Tyr Ser Leu 85 90 95 Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 <210> 26 <211> 324 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 26 agctacgagc tgacccagcc gctgtcggtg tcagtcgccc tgggacaaac tgccaggatc 60 acttgttccg gggacgcatt gcgggacaag ttcgtgtact ggtaccagca gaagccgggt 120 caagccccag tgctcgtgat ctacgacgac aacaaccggc cttccggtat ccccgaacgc 180 ttctccggat ccaatagcgg aaacaccgcc accctgacca tttcgagagc tcaggccggg 240 gatgaagcgg actactactg ccagtcatgg gatcactcgt actccctcgt cgtgtttgga 300 ggcggcacga agcttactgt gctg 324 <210> 27 <211> 214 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 27 Ser Tyr Glu Leu Thr Gln Pro Leu Ser Val Ser Val Ala Leu Gly Gln 1 5 10 15 Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Arg Asp Lys Phe Val 20 25 30 Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45 Asp Asp Asn Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 50 55 60 Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Ala Gln Ala Gly 65 70 75 80 Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Trp Asp His Ser Tyr Ser Leu 85 90 95 Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 100 105 110 Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 115 120 125 Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 130 135 140 Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 145 150 155 160 Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 165 170 175 Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 180 185 190 Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 195 200 205 Ala Pro Thr Glu Cys Ser 210 <210> 28 <211> 642 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 28 agctacgagc tgacccagcc gctgtcggtg tcagtcgccc tgggacaaac tgccaggatc 60 acttgttccg gggacgcatt gcgggacaag ttcgtgtact ggtaccagca gaagccgggt 120 caagccccag tgctcgtgat ctacgacgac aacaaccggc cttccggtat ccccgaacgc 180 ttctccggat ccaatagcgg aaacaccgcc accctgacca tttcgagagc tcaggccggg 240 gatgaagcgg actactactg ccagtcatgg gatcactcgt actccctcgt cgtgtttgga 300 ggcggcacga agcttactgt gctgggccag cctaaggccg ctccctccgt gaccctgttc 360 ccccccagct ccgaggaact gcaggccaac aaggccaccc tggtgtgcct gatcagcgac 420 ttctaccctg gcgccgtgac cgtggcctgg aaggccgaca gcagccccgt gaaggccggc 480 gtggagacaa ccacccccag caagcagagc aacaacaagt acgccgccag cagctacctg 540 agcctgaccc ccgagcagtg gaagagccac agaagctaca gctgccaggt cacccacgag 600 ggcagcaccg tggagaaaac cgtggccccc accgagtgca gc 642 <210> 29 <211> 108 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 29 Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 1 5 10 15 Thr Ala Ser Ile Thr Cys Ser Gly Asp Ala Leu Arg Asp Lys Phe Val 20 25 30 Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 35 40 45 Asp Asp Asn Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 50 55 60 Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 65 70 75 80 Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Trp Asp His Ser Tyr Ser Leu 85 90 95 Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 <210> 30 <211> 324 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 30 tcgtacgagc tcactcaacc gccttctgtg tccgtgtcac ccgggcagac tgcctccatt 60 acctgttcgg gagatgccct gcgcgacaag tttgtgtact ggtaccagca gaagcccgga 120 cagtcgccag tgctcgtcat ctatgacgac aacaacagac cttccggtat cccggaacgg 180 ttcagcggaa gcaattccgg caacaccgct accctgacca ttagcggcac tcaggccatg 240 gacgaagcgg attactactg ccaatcctgg gaccactcat actcccttgt ggtgttcggt 300 ggcggaacga agctgaccgt cctg 324 <210> 31 <211> 214 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 31 Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 1 5 10 15 Thr Ala Ser Ile Thr Cys Ser Gly Asp Ala Leu Arg Asp Lys Phe Val 20 25 30 Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 35 40 45 Asp Asp Asn Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 50 55 60 Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 65 70 75 80 Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Trp Asp His Ser Tyr Ser Leu 85 90 95 Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 100 105 110 Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 115 120 125 Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 130 135 140 Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 145 150 155 160 Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 165 170 175 Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 180 185 190 Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 195 200 205 Ala Pro Thr Glu Cys Ser 210 <210> 32 <211> 642 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 32 tcgtacgagc tcactcaacc gccttctgtg tccgtgtcac ccgggcagac tgcctccatt 60 acctgttcgg gagatgccct gcgcgacaag tttgtgtact ggtaccagca gaagcccgga 120 cagtcgccag tgctcgtcat ctatgacgac aacaacagac cttccggtat cccggaacgg 180 ttcagcggaa gcaattccgg caacaccgct accctgacca ttagcggcac tcaggccatg 240 gacgaagcgg attactactg ccaatcctgg gaccactcat actcccttgt ggtgttcggt 300 ggcggaacga agctgaccgt cctgggccag cctaaggccg ctccctccgt gaccctgttc 360 ccccccagct ccgaggaact gcaggccaac aaggccaccc tggtgtgcct gatcagcgac 420 ttctaccctg gcgccgtgac cgtggcctgg aaggccgaca gcagccccgt gaaggccggc 480 gtggagacaa ccacccccag caagcagagc aacaacaagt acgccgccag cagctacctg 540 agcctgaccc ccgagcagtg gaagagccac agaagctaca gctgccaggt cacccacgag 600 ggcagcaccg tggagaaaac cgtggccccc accgagtgca gc 642 <210> 33 <211> 10 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 33 Gly Gly Thr Phe Ser Thr Tyr Ala Ile Ser 1 5 10 <210> 34 <211> 17 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 34 Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 35 <211> 8 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 35 Glu Val Arg Met Ile Phe Asp Tyr 1 5 <210> 36 <211> 5 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 36 Thr Tyr Ala Ile Ser 1 5 <210> 37 <211> 7 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 37 Gly Gly Thr Phe Ser Thr Tyr 1 5 <210> 38 <211> 6 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 38 Ile Pro Ile Leu Gly Ile 1 5 <210> 39 <211> 8 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 39 Gly Gly Thr Phe Ser Thr Tyr Ala 1 5 <210> 40 <211> 8 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 40 Ile Ile Pro Ile Leu Gly Ile Ala 1 5 <210> 41 <211> 10 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 41 Ala Arg Glu Val Arg Met Ile Phe Asp Tyr 1 5 10 <210> 42 <211> 117 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 42 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Thr Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Val Arg Met Ile Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 <210> 43 <211> 351 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 43 caggtgcaat tggtgcagag cggtgccgaa gtgaaaaaac cgggcagcag cgtgaaagtt 60 agctgcaaag catccggagg gacgttttct acttacgcta tctcttgggt gcgccaggcc 120 ccgggccagg gcctcgagtg gatgggccgt atcatcccga tcctgggcat cgcgaactac 180 gcccagaaat ttcagggccg ggtgaccatt accgccgatg aaagcaccag caccgcctat 240 atggaactga gcagcctgcg cagcgaagat acggccgtgt attattgcgc gcgtgaagtt 300 cgtatgatct tcgattactg gggccaaggc accctggtga ctgttagctc a 351 <210> 44 <211> 447 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 44 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Thr Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Val Arg Met Ile Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 115 120 125 Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 130 135 140 Leu Val Lys Asp Tyr Phe Pro Cys Pro Val Thr Val Ser Trp Asn Ser 145 150 155 160 Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 165 170 175 Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 180 185 190 Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 195 200 205 Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 210 215 220 Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 225 230 235 240 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 245 250 255 Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 260 265 270 Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 275 280 285 Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 290 295 300 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 305 310 315 320 Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 325 330 335 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 340 345 350 Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 355 360 365 Val Lys Gly Phe Tyr Pro Cys Asp Ile Ala Val Glu Trp Glu Ser Asn 370 375 380 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 385 390 395 400 Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 405 410 415 Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 420 425 430 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 435 440 445 <210> 45 <211> 1341 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 45 caggtgcaat tggtgcagag cggtgccgaa gtgaaaaaac cgggcagcag cgtgaaagtt 60 agctgcaaag catccggagg gacgttttct acttacgcta tctcttgggt gcgccaggcc 120 ccgggccagg gcctcgagtg gatgggccgt atcatcccga tcctgggcat cgcgaactac 180 gcccagaaat ttcagggccg ggtgaccatt accgccgatg aaagcaccag caccgcctat 240 atggaactga gcagcctgcg cagcgaagat acggccgtgt attattgcgc gcgtgaagtt 300 cgtatgatct tcgattactg gggccaaggc accctggtga ctgttagctc agcctctacg 360 aaaggcccaa gcgtatttcc cctggctcct tctagtaaat caacctcagg tggtacagca 420 gcccttggct gcctggtcaa agactatttc ccctgtccgg tgaccgtctc atggaactca 480 ggtgctttga catctggtgt gcatacattc ccagctgtgc tgcaaagtag tggactgtac 540 agcctttcca gcgtggtcac ggtgccaagt agctccttgg gtactcagac ttatatctgc 600 aatgtgaacc acaagccctc taacacgaag gtggacaagc gcgtggagcc caaatcttgc 660 gataagacgc atacttgtcc cccatgccct gctcctgagc tgttgggagg cccgtcagtg 720 ttcttgttcc ctccgaagcc taaggacact ttgatgataa gtaggacacc agaggtgact 780 tgcgtggtgg ttgatgtgtc ccatgaagat cccgaggtca aatttaattg gtacgtagat 840 ggtgtcgaag ttcacaatgc taagactaag ccaagggaag agcagtacaa cagtacatat 900 agggtagtct ccgtgctgac agtcctccac caggactggt tgaacggcaa ggaatacaaa 960 tgtaaggtgt caaacaaagc tctgcctgct cccattgaga aaacaatctc taaagccaaa 1020 ggccagccga gagagcccca agtctacact ttgcccccga gcagggagga aatgaccaag 1080 aatcaggtga gtctgacgtg cctcgtcaaa ggattttatc catgcgatat tgcagttgaa 1140 tgggagagca atggccagcc agagaacaac tataaaacca caccacccgt gctcgactct 1200 gatggcagct tcttcctcta tagcaagctg acagtcgata aatctcgctg gcagcaaggc 1260 aatgtgttct cctgctccgt catgcacgag gctttgcata accattatac tcaaaaatct 1320 ctgtccctgt cacctggtaa a 1341 <210> 46 <211> 11 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 46 Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Ala 1 5 10 <210> 47 <211> 7 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 47 Ala Ala Ser Ser Leu Gln Ser 1 5 <210> 48 <211> 8 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 48 Gln Gln Ser Tyr Asp Tyr Tyr Thr 1 5 <210> 49 <211> 7 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 49 Ser Gln Ser Ile Ser Ser Tyr 1 5 <210> 50 <211> 3 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 50 Ala Ala Ser 1 <210> 51 <211> 5 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 51 Ser Tyr Asp Tyr Tyr 1 5 <210> 52 <211> 6 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 52 Gln Ser Ile Ser Ser Tyr 1 5 <210> 53 <211> 106 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 53 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Asp Tyr Tyr Thr 85 90 95 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 54 <211> 318 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 54 gatatccaga tgacccagag cccgagcagc ctgagcgcca gcgtgggcga tcgcgtgacc 60 attacctgca gagccagcca gtctatttct tcttacctgg cttggtacca gcagaaaccg 120 ggcaaagcgc cgaaactatt aatctacgct gcttcttctc tgcaaagcgg cgtgccgagc 180 cgctttagcg gcagcggatc cggcaccgat ttcaccctga ccattagctc tctgcaaccg 240 gaagactttg cgacctatta ttgccagcag tcttacgact actacacctt tggccagggc 300 acgaaagttg aaattaaa 318 <210> 55 <211> 213 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 55 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Asp Tyr Tyr Thr 85 90 95 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 100 105 110 Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 115 120 125 Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 130 135 140 Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 145 150 155 160 Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 165 170 175 Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 180 185 190 Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 195 200 205 Asn Arg Gly Glu Cys 210 <210> 56 <211> 639 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 56 gatatccaga tgacccagag cccgagcagc ctgagcgcca gcgtgggcga tcgcgtgacc 60 attacctgca gagccagcca gtctatttct tcttacctgg cttggtacca gcagaaaccg 120 ggcaaagcgc cgaaactatt aatctacgct gcttcttctc tgcaaagcgg cgtgccgagc 180 cgctttagcg gcagcggatc cggcaccgat ttcaccctga ccattagctc tctgcaaccg 240 gaagactttg cgacctatta ttgccagcag tcttacgact actacacctt tggccagggc 300 acgaaagttg aaattaaacg tacggtggca gctccgtctg ttttcatctt tccacctagc 360 gacgagcaac tcaaaagtgg tacagcatcc gtggtttgtc tgctgaacaa tttttacccc 420 agggaggcta aggtccagtg gaaagtcgat aacgctcttc agtctggcaa cagtcaggag 480 agcgtcacag agcaggactc taaggatagc acttatagtc tgtcctccac gctgacactg 540 tctaaagcgg attatgagaa gcacaaggtt tacgcctgtg aggtaacgca ccaaggactc 600 tcctccccag ttaccaaatc tttcaacaga ggagaatgt 639 <210> 57 <211> 10 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 57 Gly Gly Thr Phe Ser Asp Tyr Ala Ile Ser 1 5 10 <210> 58 <211> 17 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 58 Gly Ile Ile Pro Ile Phe Gly Asp Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 59 <211> 10 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 59 Glu Gly Ser Ser Tyr Phe Tyr Met Ala Tyr 1 5 10 <210> 60 <211> 5 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 60 Asp Tyr Ala Ile Ser 1 5 <210> 61 <211> 6 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 61 Ile Pro Ile Phe Gly Asp 1 5 <210> 62 <211> 8 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 62 Ile Ile Pro Ile Phe Gly Asp Ala 1 5 <210> 63 <211> 12 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 63 Ala Arg Glu Gly Ser Ser Tyr Phe Tyr Met Ala Tyr 1 5 10 <210> 64 <211> 119 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 64 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asp Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Asp Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Gly Ser Ser Tyr Phe Tyr Met Ala Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 65 <211> 357 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 65 caggttcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggcagcag cgtgaaggtg 60 tcctgcaaag caagcggcgg caccttcagc gattacgcca tctcttgggt ccgacaggcc 120 cctggacaag gcttggaatg gatgggcggc atcatcccca tcttcggcga cgccaattac 180 gcccagaaat tccagggcag agtgaccatc accgccgacg agtctacaag caccgcctac 240 atggaactga gcagcctgag aagcgaggac accgccgtgt actactgtgc cagagagggc 300 agcagctact tctacatggc ctattggggc cagggcaccc tggtcacagt tagctct 357 <210> 66 <211> 449 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 66 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asp Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Asp Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Gly Ser Ser Tyr Phe Tyr Met Ala Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 115 120 125 Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 130 135 140 Gly Cys Leu Val Lys Asp Tyr Phe Pro Cys Pro Val Thr Val Ser Trp 145 150 155 160 Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 165 170 175 Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 180 185 190 Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 195 200 205 Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 210 215 220 Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 225 230 235 240 Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 245 250 255 Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 260 265 270 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 275 280 285 Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 290 295 300 Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 305 310 315 320 Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 325 330 335 Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 340 345 350 Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 355 360 365 Cys Leu Val Lys Gly Phe Tyr Pro Cys Asp Ile Ala Val Glu Trp Glu 370 375 380 Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 385 390 395 400 Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 405 410 415 Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 420 425 430 Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 435 440 445 Lys <210> 67 <211> 1347 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 67 caggttcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggcagcag cgtgaaggtg 60 tcctgcaaag caagcggcgg caccttcagc gattacgcca tctcttgggt ccgacaggcc 120 cctggacaag gcttggaatg gatgggcggc atcatcccca tcttcggcga cgccaattac 180 gcccagaaat tccagggcag agtgaccatc accgccgacg agtctacaag caccgcctac 240 atggaactga gcagcctgag aagcgaggac accgccgtgt actactgtgc cagagagggc 300 agcagctact tctacatggc ctattggggc cagggcaccc tggtcacagt tagctctgct 360 agcaccaagg gcccaagtgt gtttcccctg gcccccagca gcaagtctac ttccggcgga 420 actgctgccc tgggttgcct ggtgaaggac tacttcccct gtcccgtgac agtgtcctgg 480 aactctgggg ctctgacttc cggcgtgcac accttccccg ccgtgctgca gagcagcggc 540 ctgtacagcc tgagcagcgt ggtgacagtg ccctccagct ctctgggaac ccagacctat 600 atctgcaacg tgaaccacaa gcccagcaac accaaggtgg acaagagagt ggagcccaag 660 agctgcgaca agacccacac ctgccccccc tgcccagctc cagaactgct gggagggcct 720 tccgtgttcc tgttcccccc caagcccaag gacaccctga tgatcagcag gacccccgag 780 gtgacctgcg tggtggtgga cgtgtcccac gaggacccag aggtgaagtt caactggtac 840 gtggacggcg tggaggtgca caacgccaag accaagccca gagaggagca gtacaacagc 900 acctacaggg tggtgtccgt gctgaccgtg ctgcaccagg actggctgaa cggcaaagaa 960 tacaagtgca aagtctccaa caaggccctg ccagccccaa tcgaaaagac aatcagcaag 1020 gccaagggcc agccacggga gccccaggtg tacaccctgc cccccagccg ggaggagatg 1080 accaagaacc aggtgtccct gacctgtctg gtgaagggct tctacccctg tgatatcgcc 1140 gtggagtggg agagcaacgg ccagcccgag aacaactaca agaccacccc cccagtgctg 1200 gacagcgacg gcagcttctt cctgtacagc aagctgaccg tggacaagtc caggtggcag 1260 cagggcaacg tgttcagctg cagcgtgatg cacgaggccc tgcacaacca ctacacccag 1320 aagtccctga gcctgagccc cggcaag 1347 <210> 68 <211> 11 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 68 Ser Gly Asp Asn Ile Gly Ser Lys Leu Ala Ser 1 5 10 <210> 69 <211> 7 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 69 Asp Asp Ser Asn Arg Pro Ser 1 5 <210> 70 <211> 11 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 70 Ala Ala Thr Ala Gly Asp Arg Trp Ala Tyr Val 1 5 10 <210> 71 <211> 7 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 71 Asp Asn Ile Gly Ser Lys Leu 1 5 <210> 72 <211> 3 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 72 Asp Asp Ser 1 <210> 73 <211> 8 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 73 Thr Ala Gly Asp Arg Trp Ala Tyr 1 5 <210> 74 <211> 6 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 74 Asn Ile Gly Ser Lys Leu 1 5 <210> 75 <211> 108 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 75 Ser Tyr Glu Leu Thr Gln Pro Leu Ser Val Ser Val Ala Leu Gly Gln 1 5 10 15 Thr Ala Arg Ile Thr Cys Ser Gly Asp Asn Ile Gly Ser Lys Leu Ala 20 25 30 Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45 Asp Asp Ser Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 50 55 60 Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Ala Gln Ala Gly 65 70 75 80 Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Thr Ala Gly Asp Arg Trp Ala 85 90 95 Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 <210> 76 <211> 324 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 76 agctatgagc tgacacagcc tctgtccgtg tctgtggctc tgggacagac cgccagaatc 60 acctgtagcg gcgacaacat cggcagcaag ctggcctctt ggtatcagca gaagcctgga 120 caggcccctg tgctggtcat ctacgacgac agcaatagac ccagcggcat ccccgagaga 180 ttcagcggca gcaatagcgg caataccgcc acactgacca tcagcagagc acaggctggc 240 gacgaggccg attactattg tgctgccaca gccggcgaca gatgggccta tgtttttggc 300 ggcggaacaa agctgaccgt gctg 324 <210> 77 <211> 214 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 77 Ser Tyr Glu Leu Thr Gln Pro Leu Ser Val Ser Val Ala Leu Gly Gln 1 5 10 15 Thr Ala Arg Ile Thr Cys Ser Gly Asp Asn Ile Gly Ser Lys Leu Ala 20 25 30 Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45 Asp Asp Ser Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 50 55 60 Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Ala Gln Ala Gly 65 70 75 80 Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Thr Ala Gly Asp Arg Trp Ala 85 90 95 Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 100 105 110 Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 115 120 125 Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 130 135 140 Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 145 150 155 160 Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 165 170 175 Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 180 185 190 Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 195 200 205 Ala Pro Thr Glu Cys Ser 210 <210> 78 <211> 642 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 78 agctatgagc tgacacagcc tctgtccgtg tctgtggctc tgggacagac cgccagaatc 60 acctgtagcg gcgacaacat cggcagcaag ctggcctctt ggtatcagca gaagcctgga 120 caggcccctg tgctggtcat ctacgacgac agcaatagac ccagcggcat ccccgagaga 180 ttcagcggca gcaatagcgg caataccgcc acactgacca tcagcagagc acaggctggc 240 gacgaggccg attactattg tgctgccaca gccggcgaca gatgggccta tgtttttggc 300 ggcggaacaa agctgaccgt gctgggacag cctaaggccg ctccctccgt gaccctgttc 360 ccccccagct ccgaggaact gcaggccaac aaggccaccc tggtgtgcct gatcagcgac 420 ttctaccctg gcgccgtgac cgtggcctgg aaggccgaca gcagccccgt gaaggccggc 480 gtggagacaa ccacccccag caagcagagc aacaacaagt acgccgccag cagctacctg 540 agcctgaccc ccgagcagtg gaagagccac agaagctaca gctgccaggt cacccacgag 600 ggcagcaccg tggagaaaac cgtggccccc accgagtgca gc 642 <210> 79 <211> 10 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 79 Gly Phe Thr Phe Ser Ser Phe Gly Met Ser 1 5 10 <210> 80 <211> 17 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 80 Ala Ile Ser Tyr Ser Gly Ser Asp Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 81 <211> 7 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 81 Asp Val Gly Val Met Asp Tyr 1 5 <210> 82 <211> 5 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 82 Ser Phe Gly Met Ser 1 5 <210> 83 <211> 7 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 83 Gly Phe Thr Phe Ser Ser Phe 1 5 <210> 84 <211> 6 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 84 Ser Tyr Ser Gly Ser Asp 1 5 <210> 85 <211> 8 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 85 Gly Phe Thr Phe Ser Ser Phe Gly 1 5 <210> 86 <211> 8 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 86 Ile Ser Tyr Ser Gly Ser Asp Thr 1 5 <210> 87 <211> 9 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 87 Ala Arg Asp Val Gly Val Met Asp Tyr 1 5 <210> 88 <211> 116 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 88 Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 20 25 30 Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Tyr Ser Gly Ser Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Val Gly Val Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 89 <211> 348 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 89 caggttcagc tgctggaatc tggcggagga ctggttcaac ctggcggctc tctgagactg 60 tcttgtgccg ccagcggctt caccttcagc agctttggca tgagctgggt ccgacaggcc 120 cctggcaaag gacttgaatg ggtgtccgcc atcagctaca gcggcagcga tacctactac 180 gccgacagcg tgaagggcag attcaccatc tccagagaca acagcaagaa caccctgtac 240 ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagagatgtg 300 ggcgtgatgg actattgggg ccagggcaca ctggtcaccg ttagctct 348 <210> 90 <211> 446 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 90 Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 20 25 30 Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Tyr Ser Gly Ser Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Val Gly Val Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 115 120 125 Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 130 135 140 Val Lys Asp Tyr Phe Pro Cys Pro Val Thr Val Ser Trp Asn Ser Gly 145 150 155 160 Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 165 170 175 Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 180 185 190 Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 195 200 205 Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 210 215 220 Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 225 230 235 240 Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 245 250 255 Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 260 265 270 Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 275 280 285 Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 290 295 300 Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 305 310 315 320 Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 325 330 335 Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 340 345 350 Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 355 360 365 Lys Gly Phe Tyr Pro Cys Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 370 375 380 Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 385 390 395 400 Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 405 410 415 Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 420 425 430 Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 435 440 445 <210> 91 <211> 1338 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 91 caggttcagc tgctggaatc tggcggagga ctggttcaac ctggcggctc tctgagactg 60 tcttgtgccg ccagcggctt caccttcagc agctttggca tgagctgggt ccgacaggcc 120 cctggcaaag gacttgaatg ggtgtccgcc atcagctaca gcggcagcga tacctactac 180 gccgacagcg tgaagggcag attcaccatc tccagagaca acagcaagaa caccctgtac 240 ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagagatgtg 300 ggcgtgatgg actattgggg ccagggcaca ctggtcaccg ttagctctgc tagcaccaag 360 ggcccaagtg tgtttcccct ggcccccagc agcaagtcta cttccggcgg aactgctgcc 420 ctgggttgcc tggtgaagga ctacttcccc tgtcccgtga cagtgtcctg gaactctggg 480 gctctgactt ccggcgtgca caccttcccc gccgtgctgc agagcagcgg cctgtacagc 540 ctgagcagcg tggtgacagt gccctccagc tctctgggaa cccagaccta tatctgcaac 600 gtgaaccaca agcccagcaa caccaaggtg gacaagagag tggagcccaa gagctgcgac 660 aagacccaca cctgcccccc ctgcccagct ccagaactgc tgggagggcc ttccgtgttc 720 ctgttccccc ccaagcccaa ggacaccctg atgatcagca ggacccccga ggtgacctgc 780 gtggtggtgg acgtgtccca cgaggaccca gaggtgaagt tcaactggta cgtggacggc 840 gtggaggtgc acaacgccaa gaccaagccc agagaggagc agtacaacag cacctacagg 900 gtggtgtccg tgctgaccgt gctgcaccag gactggctga acggcaaaga atacaagtgc 960 aaagtctcca acaaggccct gccagcccca atcgaaaaga caatcagcaa ggccaagggc 1020 cagccacggg agccccaggt gtacaccctg ccccccagcc gggaggagat gaccaagaac 1080 caggtgtccc tgacctgtct ggtgaagggc ttctacccct gtgatatcgc cgtggagtgg 1140 gagagcaacg gccagcccga gaacaactac aagaccaccc ccccagtgct ggacagcgac 1200 ggcagcttct tcctgtacag caagctgacc gtggacaagt ccaggtggca gcagggcaac 1260 gtgttcagct gcagcgtgat gcacgaggcc ctgcacaacc actacaccca gaagtccctg 1320 agcctgagcc ccggcaag 1338 <210> 92 <211> 11 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 92 Ser Gly Asp Asn Leu Gly Thr Tyr Tyr Ala His 1 5 10 <210> 93 <211> 7 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 93 Ser Gln Ser His Arg Pro Ser 1 5 <210> 94 <211> 11 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 94 Gly Ala Trp Asp Ala Pro Ser Pro Glu Leu Val 1 5 10 <210> 95 <211> 7 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 95 Asp Asn Leu Gly Thr Tyr Tyr 1 5 <210> 96 <211> 3 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 96 Ser Gln Ser 1 <210> 97 <211> 8 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 97 Trp Asp Ala Pro Ser Pro Glu Leu 1 5 <210> 98 <211> 6 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 98 Asn Leu Gly Thr Tyr Tyr 1 5 <210> 99 <211> 108 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 99 Ser Tyr Glu Leu Thr Gln Pro Leu Ser Val Ser Val Ala Leu Gly Gln 1 5 10 15 Thr Ala Arg Ile Thr Cys Ser Gly Asp Asn Leu Gly Thr Tyr Tyr Ala 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45 Ser Gln Ser His Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 50 55 60 Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Ala Gln Ala Gly 65 70 75 80 Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Trp Asp Ala Pro Ser Pro Glu 85 90 95 Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 <210> 100 <211> 324 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 100 agctatgagc tgacacagcc tctgtccgtg tctgtggctc tgggacagac cgccagaatc 60 acctgtagcg gcgataacct gggcacctac tacgcccact ggtatcagca gaagcctgga 120 caggctcccg tgctggtcat ctacagccag tctcacagac ccagcggcat ccccgagaga 180 ttcagcggca gcaatagcgg caataccgcc acactgacca tcagcagagc acaggctggc 240 gacgaggccg attactattg tggcgcttgg gacgccccat ctcctgagct tgtttttggc 300 ggaggcacca agctgacagt gctg 324 <210> 101 <211> 214 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 101 Ser Tyr Glu Leu Thr Gln Pro Leu Ser Val Ser Val Ala Leu Gly Gln 1 5 10 15 Thr Ala Arg Ile Thr Cys Ser Gly Asp Asn Leu Gly Thr Tyr Tyr Ala 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45 Ser Gln Ser His Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 50 55 60 Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Ala Gln Ala Gly 65 70 75 80 Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Trp Asp Ala Pro Ser Pro Glu 85 90 95 Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 100 105 110 Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 115 120 125 Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 130 135 140 Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 145 150 155 160 Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 165 170 175 Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 180 185 190 Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 195 200 205 Ala Pro Thr Glu Cys Ser 210 <210> 102 <211> 642 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 102 agctatgagc tgacacagcc tctgtccgtg tctgtggctc tgggacagac cgccagaatc 60 acctgtagcg gcgataacct gggcacctac tacgcccact ggtatcagca gaagcctgga 120 caggctcccg tgctggtcat ctacagccag tctcacagac ccagcggcat ccccgagaga 180 ttcagcggca gcaatagcgg caataccgcc acactgacca tcagcagagc acaggctggc 240 gacgaggccg attactattg tggcgcttgg gacgccccat ctcctgagct tgtttttggc 300 ggaggcacca agctgacagt gctgggacag cctaaggccg ctccctccgt gaccctgttc 360 ccccccagct ccgaggaact gcaggccaac aaggccaccc tggtgtgcct gatcagcgac 420 ttctaccctg gcgccgtgac cgtggcctgg aaggccgaca gcagccccgt gaaggccggc 480 gtggagacaa ccacccccag caagcagagc aacaacaagt acgccgccag cagctacctg 540 agcctgaccc ccgagcagtg gaagagccac agaagctaca gctgccaggt cacccacgag 600 ggcagcaccg tggagaaaac cgtggccccc accgagtgca gc 642 <210> 103 <211> 10 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 103 Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser 1 5 10 <210> 104 <211> 17 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 104 Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 105 <211> 9 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 105 Ala Phe Arg Leu Tyr Trp Leu Asp Val 1 5 <210> 106 <211> 5 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 106 Ser Tyr Ala Met Ser 1 5 <210> 107 <211> 7 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 107 Gly Phe Thr Phe Ser Ser Tyr 1 5 <210> 108 <211> 6 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 108 Ser Gly Ser Gly Gly Ser 1 5 <210> 109 <211> 8 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 109 Gly Phe Thr Phe Ser Ser Tyr Ala 1 5 <210> 110 <211> 8 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 110 Ile Ser Gly Ser Gly Gly Ser Thr 1 5 <210> 111 <211> 11 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 111 Ala Arg Ala Phe Arg Leu Tyr Trp Leu Asp Val 1 5 10 <210> 112 <211> 118 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 112 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ala Phe Arg Leu Tyr Trp Leu Asp Val Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 113 <211> 354 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 113 gaagttcagc tgctggaatc tggcggagga ctggttcaac ctggcggctc tctgagactg 60 tcttgtgccg ccagcggctt cacctttagc agctacgcca tgagctgggt ccgacaggct 120 cctggcaaag gccttgaatg ggtgtccgcc atctctggct ctggcggcag cacatattac 180 gccgactctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac 240 ctgcagatga acagcctgag agccgaggac accgccgtgt actattgtgc cagagccttc 300 cggctgtact ggctggatgt ttggggacag ggcaccctgg tcacagtgtc atct 354 <210> 114 <211> 448 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 114 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ala Phe Arg Leu Tyr Trp Leu Asp Val Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 115 120 125 Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 130 135 140 Cys Leu Val Lys Asp Tyr Phe Pro Cys Pro Val Thr Val Ser Trp Asn 145 150 155 160 Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 165 170 175 Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 180 185 190 Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 195 200 205 Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 210 215 220 His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 225 230 235 240 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 245 250 255 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 260 265 270 Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 275 280 285 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 290 295 300 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 305 310 315 320 Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 325 330 335 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 340 345 350 Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 355 360 365 Leu Val Lys Gly Phe Tyr Pro Cys Asp Ile Ala Val Glu Trp Glu Ser 370 375 380 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 385 390 395 400 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 405 410 415 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 420 425 430 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 435 440 445 <210> 115 <211> 1344 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 115 gaagttcagc tgctggaatc tggcggagga ctggttcaac ctggcggctc tctgagactg 60 tcttgtgccg ccagcggctt cacctttagc agctacgcca tgagctgggt ccgacaggct 120 cctggcaaag gccttgaatg ggtgtccgcc atctctggct ctggcggcag cacatattac 180 gccgactctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac 240 ctgcagatga acagcctgag agccgaggac accgccgtgt actattgtgc cagagccttc 300 cggctgtact ggctggatgt ttggggacag ggcaccctgg tcacagtgtc atctgctagc 360 accaagggcc caagtgtgtt tcccctggcc cccagcagca agtctacttc cggcggaact 420 gctgccctgg gttgcctggt gaaggactac ttcccctgtc ccgtgacagt gtcctggaac 480 tctggggctc tgacttccgg cgtgcacacc ttccccgccg tgctgcagag cagcggcctg 540 tacagcctga gcagcgtggt gacagtgccc tccagctctc tgggaaccca gacctatatc 600 tgcaacgtga accacaagcc cagcaacacc aaggtggaca agagagtgga gcccaagagc 660 tgcgacaaga cccacacctg ccccccctgc ccagctccag aactgctggg agggccttcc 720 gtgttcctgt tcccccccaa gcccaaggac accctgatga tcagcaggac ccccgaggtg 780 acctgcgtgg tggtggacgt gtcccacgag gacccagagg tgaagttcaa ctggtacgtg 840 gacggcgtgg aggtgcacaa cgccaagacc aagcccagag aggagcagta caacagcacc 900 tacagggtgg tgtccgtgct gaccgtgctg caccaggact ggctgaacgg caaagaatac 960 aagtgcaaag tctccaacaa ggccctgcca gccccaatcg aaaagacaat cagcaaggcc 1020 aagggccagc cacgggagcc ccaggtgtac accctgcccc ccagccggga ggagatgacc 1080 aagaaccagg tgtccctgac ctgtctggtg aagggcttct acccctgtga tatcgccgtg 1140 gagtgggaga gcaacggcca gcccgagaac aactacaaga ccaccccccc agtgctggac 1200 agcgacggca gcttcttcct gtacagcaag ctgaccgtgg acaagtccag gtggcagcag 1260 ggcaacgtgt tcagctgcag cgtgatgcac gaggccctgc acaaccacta cacccagaag 1320 tccctgagcc tgagccccgg caag 1344 <210> 116 <211> 11 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 116 Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 1 5 10 <210> 117 <211> 9 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 117 Gln Gln Val Tyr Ser Ala Pro Val Thr 1 5 <210> 118 <211> 6 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 118 Val Tyr Ser Ala Pro Val 1 5 <210> 119 <211> 107 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 119 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Tyr Ser Ala Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 120 <211> 321 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 120 gacatccaga tgacacagag ccctagcagc ctgtctgcca gcgtgggaga cagagtgacc 60 atcacctgta gagccagcca gagcatcagc agctacctga actggtatca gcagaagccc 120 ggcaaggccc ctaaactgct gatctatgcc gccagctctc tgcagtctgg cgtgccaagc 180 agattttctg gcagcggctc tggcaccgac ttcaccctga ccatatctag cctgcagcca 240 gaggacttcg ccacctacta ctgccagcag gtctacagcg cccctgtgac atttggccag 300 ggcaccaagg tggaaatcaa g 321 <210> 121 <211> 214 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 121 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Tyr Ser Ala Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 100 105 110 Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 115 120 125 Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 130 135 140 Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 145 150 155 160 Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 165 170 175 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 180 185 190 Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 195 200 205 Phe Asn Arg Gly Glu Cys 210 <210> 122 <211> 642 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 122 gacatccaga tgacacagag ccctagcagc ctgtctgcca gcgtgggaga cagagtgacc 60 atcacctgta gagccagcca gagcatcagc agctacctga actggtatca gcagaagccc 120 ggcaaggccc ctaaactgct gatctatgcc gccagctctc tgcagtctgg cgtgccaagc 180 agattttctg gcagcggctc tggcaccgac ttcaccctga ccatatctag cctgcagcca 240 gaggacttcg ccacctacta ctgccagcag gtctacagcg cccctgtgac atttggccag 300 ggcaccaagg tggaaatcaa gcgtacggtg gccgctccca gcgtgttcat cttccccccc 360 agcgacgagc agctgaagag tggcaccgcc agcgtggtgt gcctgctgaa caacttctac 420 ccccgggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag 480 gagagcgtca ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc 540 ctgagcaagg ccgactacga gaagcataag gtgtacgcct gcgaggtgac ccaccagggc 600 ctgtccagcc ccgtgaccaa gagcttcaac aggggcgagt gc 642 <210> 123 <211> 10 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 123 Gly Phe Thr Phe Ser Asn Tyr Trp Ile Ser 1 5 10 <210> 124 <211> 19 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 124 Arg Ile Lys Ser Lys Thr Tyr Gly Gly Thr Thr Asp Tyr Ala Glu Pro 1 5 10 15 Val Lys Gly <210> 125 <211> 10 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 125 Thr Ser Arg Arg Ser Tyr Ala Phe Asp Tyr 1 5 10 <210> 126 <211> 5 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 126 Asn Tyr Trp Ile Ser 1 5 <210> 127 <211> 7 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 127 Gly Phe Thr Phe Ser Asn Tyr 1 5 <210> 128 <211> 8 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 128 Lys Ser Lys Thr Tyr Gly Gly Thr 1 5 <210> 129 <211> 8 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 129 Gly Phe Thr Phe Ser Asn Tyr Trp 1 5 <210> 130 <211> 10 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 130 Ile Lys Ser Lys Thr Tyr Gly Gly Thr Thr 1 5 10 <210> 131 <211> 12 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 131 Ala Arg Thr Ser Arg Arg Ser Tyr Ala Phe Asp Tyr 1 5 10 <210> 132 <211> 121 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 132 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Trp Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Arg Ile Lys Ser Lys Thr Tyr Gly Gly Thr Thr Asp Tyr Ala Glu 50 55 60 Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Ala Arg Thr Ser Arg Arg Ser Tyr Ala Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 133 <211> 363 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 133 gaagtgcagc tggtggaatc tggcggcgga cttgtgaaac ctggcggctc tctgagactg 60 agctgtgccg cttccggctt caccttcagc aactactgga tcagctgggt ccgacaggcc 120 cctggcaaag gacttgagtg ggtcggacgg atcaagagca agacctacgg cggcaccacc 180 gattatgccg agcctgtgaa gggcagattc accatcagcc gggacgacag caagaacacc 240 ctgtacctgc agatgaacag cctgaaaacc gaggacaccg ccgtgtacta ctgcgccaga 300 accagcagaa gaagctacgc cttcgactac tggggccagg gcacactggt taccgttagc 360 tct 363 <210> 134 <211> 451 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 134 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Trp Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Arg Ile Lys Ser Lys Thr Tyr Gly Gly Thr Thr Asp Tyr Ala Glu 50 55 60 Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Ala Arg Thr Ser Arg Arg Ser Tyr Ala Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 115 120 125 Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 130 135 140 Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Cys Pro Val Thr Val 145 150 155 160 Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 165 170 175 Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 180 185 190 Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 195 200 205 Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 210 215 220 Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 225 230 235 240 Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 245 250 255 Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 260 265 270 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 275 280 285 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 290 295 300 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 305 310 315 320 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 325 330 335 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 340 345 350 Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 355 360 365 Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Cys Asp Ile Ala Val Glu 370 375 380 Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 385 390 395 400 Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 405 410 415 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 420 425 430 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 435 440 445 Pro Gly Lys 450 <210> 135 <211> 1353 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 135 gaagtgcagc tggtggaatc tggcggcgga cttgtgaaac ctggcggctc tctgagactg 60 agctgtgccg cttccggctt caccttcagc aactactgga tcagctgggt ccgacaggcc 120 cctggcaaag gacttgagtg ggtcggacgg atcaagagca agacctacgg cggcaccacc 180 gattatgccg agcctgtgaa gggcagattc accatcagcc gggacgacag caagaacacc 240 ctgtacctgc agatgaacag cctgaaaacc gaggacaccg ccgtgtacta ctgcgccaga 300 accagcagaa gaagctacgc cttcgactac tggggccagg gcacactggt taccgttagc 360 tctgctagca ccaagggccc aagtgtgttt cccctggccc ccagcagcaa gtctacttcc 420 ggcggaactg ctgccctggg ttgcctggtg aaggactact tcccctgtcc cgtgacagtg 480 tcctggaact ctggggctct gacttccggc gtgcacacct tccccgccgt gctgcagagc 540 agcggcctgt acagcctgag cagcgtggtg acagtgccct ccagctctct gggaacccag 600 acctatatct gcaacgtgaa ccacaagccc agcaacacca aggtggacaa gagagtggag 660 cccaagagct gcgacaagac ccacacctgc cccccctgcc cagctccaga actgctggga 720 gggccttccg tgttcctgtt cccccccaag cccaaggaca ccctgatgat cagcaggacc 780 cccgaggtga cctgcgtggt ggtggacgtg tcccacgagg acccagaggt gaagttcaac 840 tggtacgtgg acggcgtgga ggtgcacaac gccaagacca agcccagaga ggagcagtac 900 aacagcacct acagggtggt gtccgtgctg accgtgctgc accaggactg gctgaacggc 960 aaagaataca agtgcaaagt ctccaacaag gccctgccag ccccaatcga aaagacaatc 1020 agcaaggcca agggccagcc acgggagccc caggtgtaca ccctgccccc cagccgggag 1080 gagatgacca agaaccaggt gtccctgacc tgtctggtga agggcttcta cccctgtgat 1140 atcgccgtgg agtgggagag caacggccag cccgagaaca actacaagac caccccccca 1200 gtgctggaca gcgacggcag cttcttcctg tacagcaagc tgaccgtgga caagtccagg 1260 tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caaccactac 1320 acccagaagt ccctgagcct gagccccggc aag 1353 <210> 136 <211> 11 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 136 Arg Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala 1 5 10 <210> 137 <211> 7 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 137 Asp Ala Ser Ser Leu Glu Ser 1 5 <210> 138 <211> 9 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 138 Gln Gln Ile Thr Arg Tyr Pro Val Thr 1 5 <210> 139 <211> 7 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 139 Ser Gln Ser Ile Ser Ser Trp 1 5 <210> 140 <211> 3 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 140 Asp Ala Ser 1 <210> 141 <211> 6 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 141 Ile Thr Arg Tyr Pro Val 1 5 <210> 142 <211> 6 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 142 Gln Ser Ile Ser Ser Trp 1 5 <210> 143 <211> 107 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 143 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ile Thr Arg Tyr Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 144 <211> 321 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 144 gacatccaga tgacacagag ccccagcaca ctgtctgcca gcgtgggaga cagagtgacc 60 atcacctgta gagccagcca gagcatctcc tcttggctgg cctggtatca gcagaagcct 120 ggcaaggccc ctaagctgct gatctacgat gccagcagcc tggaaagcgg cgtgccaagc 180 agattttctg gcagcggctc tggcaccgag ttcaccctga ccatatctag cctgcagcca 240 gaggacttcg ccacctacta ctgccagcag atcacaagat accccgtgac ctttggccag 300 ggcaccaagg tggaaatcaa g 321 <210> 145 <211> 214 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 145 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ile Thr Arg Tyr Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 100 105 110 Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 115 120 125 Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 130 135 140 Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 145 150 155 160 Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 165 170 175 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 180 185 190 Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 195 200 205 Phe Asn Arg Gly Glu Cys 210 <210> 146 <211> 642 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 146 gacatccaga tgacacagag ccccagcaca ctgtctgcca gcgtgggaga cagagtgacc 60 atcacctgta gagccagcca gagcatctcc tcttggctgg cctggtatca gcagaagcct 120 ggcaaggccc ctaagctgct gatctacgat gccagcagcc tggaaagcgg cgtgccaagc 180 agattttctg gcagcggctc tggcaccgag ttcaccctga ccatatctag cctgcagcca 240 gaggacttcg ccacctacta ctgccagcag atcacaagat accccgtgac ctttggccag 300 ggcaccaagg tggaaatcaa gcgtacggtg gccgctccca gcgtgttcat cttccccccc 360 agcgacgagc agctgaagag tggcaccgcc agcgtggtgt gcctgctgaa caacttctac 420 ccccgggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag 480 gagagcgtca ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc 540 ctgagcaagg ccgactacga gaagcataag gtgtacgcct gcgaggtgac ccaccagggc 600 ctgtccagcc ccgtgaccaa gagcttcaac aggggcgagt gc 642 <210> 147 <211> 13 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 147 Val Ser Gly Tyr Tyr Ser His Ser Gly Gly Phe Asp Val 1 5 10 <210> 148 <211> 15 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 148 Ala Arg Val Ser Gly Tyr Tyr Ser His Ser Gly Gly Phe Asp Val 1 5 10 15 <210> 149 <211> 124 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 149 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Trp Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Arg Ile Lys Ser Lys Thr Tyr Gly Gly Thr Thr Asp Tyr Ala Glu 50 55 60 Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Ala Arg Val Ser Gly Tyr Tyr Ser His Ser Gly Gly Phe Asp 100 105 110 Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 150 <211> 372 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 150 gaagtgcagc tggtggaatc tggcggcgga cttgtgaaac ctggcggctc tctgagactg 60 agctgtgccg cttccggctt caccttcagc aactactgga tcagctgggt ccgacaggcc 120 cctggcaaag gacttgagtg ggtcggacgg atcaagagca agacctacgg cggcaccacc 180 gattatgccg agcctgtgaa gggcagattc accatcagcc gggacgacag caagaacacc 240 ctgtacctgc agatgaacag cctgaaaacc gaggacaccg ccgtgtacta ctgcgccaga 300 gtgtctggct actactctca cagcggcggc tttgatgtgt ggggccaggg aacactggtc 360 accgttagtt ct 372 <210> 151 <211> 454 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 151 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Trp Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Arg Ile Lys Ser Lys Thr Tyr Gly Gly Thr Thr Asp Tyr Ala Glu 50 55 60 Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Ala Arg Val Ser Gly Tyr Tyr Ser His Ser Gly Gly Phe Asp 100 105 110 Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 115 120 125 Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 130 135 140 Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Cys Pro 145 150 155 160 Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 165 170 175 Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 180 185 190 Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 195 200 205 Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 210 215 220 Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 225 230 235 240 Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 245 250 255 Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 260 265 270 Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 275 280 285 Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 290 295 300 Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 305 310 315 320 Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 325 330 335 Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 340 345 350 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 355 360 365 Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Cys Asp Ile 370 375 380 Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 385 390 395 400 Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 405 410 415 Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 420 425 430 Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 435 440 445 Ser Leu Ser Pro Gly Lys 450 <210> 152 <211> 1362 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 152 gaagtgcagc tggtggaatc tggcggcgga cttgtgaaac ctggcggctc tctgagactg 60 agctgtgccg cttccggctt caccttcagc aactactgga tcagctgggt ccgacaggcc 120 cctggcaaag gacttgagtg ggtcggacgg atcaagagca agacctacgg cggcaccacc 180 gattatgccg agcctgtgaa gggcagattc accatcagcc gggacgacag caagaacacc 240 ctgtacctgc agatgaacag cctgaaaacc gaggacaccg ccgtgtacta ctgcgccaga 300 gtgtctggct actactctca cagcggcggc tttgatgtgt ggggccaggg aacactggtc 360 accgttagtt ctgctagcac caagggccca agtgtgtttc ccctggcccc cagcagcaag 420 tctacttccg gcggaactgc tgccctgggt tgcctggtga aggactactt cccctgtccc 480 gtgacagtgt cctggaactc tggggctctg acttccggcg tgcacacctt ccccgccgtg 540 ctgcagagca gcggcctgta cagcctgagc agcgtggtga cagtgccctc cagctctctg 600 ggaacccaga cctatatctg caacgtgaac cacaagccca gcaacaccaa ggtggacaag 660 agagtggagc ccaagagctg cgacaagacc cacacctgcc ccccctgccc agctccagaa 720 ctgctgggag ggccttccgt gttcctgttc ccccccaagc ccaaggacac cctgatgatc 780 agcaggaccc ccgaggtgac ctgcgtggtg gtggacgtgt cccacgagga cccagaggtg 840 aagttcaact ggtacgtgga cggcgtggag gtgcacaacg ccaagaccaa gcccagagag 900 gagcagtaca acagcaccta cagggtggtg tccgtgctga ccgtgctgca ccaggactgg 960 ctgaacggca aagaatacaa gtgcaaagtc tccaacaagg ccctgccagc cccaatcgaa 1020 aagacaatca gcaaggccaa gggccagcca cgggagcccc aggtgtacac cctgcccccc 1080 agccgggagg agatgaccaa gaaccaggtg tccctgacct gtctggtgaa gggcttctac 1140 ccctgtgata tcgccgtgga gtgggagagc aacggccagc ccgagaacaa ctacaagacc 1200 acccccccag tgctggacag cgacggcagc ttcttcctgt acagcaagct gaccgtggac 1260 aagtccaggt ggcagcaggg caacgtgttc agctgcagcg tgatgcacga ggccctgcac 1320 aaccactaca cccagaagtc cctgagcctg agccccggca ag 1362 <210> 153 <211> 11 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 153 Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Ala 1 5 10 <210> 154 <211> 7 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 154 Ala Ala Ser Thr Leu Gln Ser 1 5 <210> 155 <211> 9 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 155 Gln Lys Thr Trp Arg Thr Pro Gly Thr 1 5 <210> 156 <211> 7 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 156 Ser Gln Gly Ile Ser Asn Tyr 1 5 <210> 157 <211> 6 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 157 Thr Trp Arg Thr Pro Gly 1 5 <210> 158 <211> 6 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 158 Gln Gly Ile Ser Asn Tyr 1 5 <210> 159 <211> 107 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 159 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys Thr Trp Arg Thr Pro Gly 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 160 <211> 321 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 160 gacatccaga tgacacagag ccctagcagc ctgtctgcca gcgtgggaga cagagtgacc 60 atcacctgta gagccagcca gggcatcagc aactacctgg cctggtatca gcagaaaccc 120 ggcaaggtgc ccaagctgct gatctacgct gccagcacac tgcagagcgg agtgcctagc 180 agattttctg gcagcggctc cggcaccgat ttcaccctga ccatatctag cctgcagcca 240 gaggacgtgg ccacctacta ctgtcagaaa acctggcgga cccctggcac atttggccag 300 ggaacaaagg tggaaatcaa g 321 <210> 161 <211> 214 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 161 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys Thr Trp Arg Thr Pro Gly 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 100 105 110 Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 115 120 125 Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 130 135 140 Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 145 150 155 160 Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 165 170 175 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 180 185 190 Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 195 200 205 Phe Asn Arg Gly Glu Cys 210 <210> 162 <211> 642 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 162 gacatccaga tgacacagag ccctagcagc ctgtctgcca gcgtgggaga cagagtgacc 60 atcacctgta gagccagcca gggcatcagc aactacctgg cctggtatca gcagaaaccc 120 ggcaaggtgc ccaagctgct gatctacgct gccagcacac tgcagagcgg agtgcctagc 180 agattttctg gcagcggctc cggcaccgat ttcaccctga ccatatctag cctgcagcca 240 gaggacgtgg ccacctacta ctgtcagaaa acctggcgga cccctggcac atttggccag 300 ggaacaaagg tggaaatcaa gcgtacggtg gccgctccca gcgtgttcat cttccccccc 360 agcgacgagc agctgaagag tggcaccgcc agcgtggtgt gcctgctgaa caacttctac 420 ccccgggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag 480 gagagcgtca ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc 540 ctgagcaagg ccgactacga gaagcataag gtgtacgcct gcgaggtgac ccaccagggc 600 ctgtccagcc ccgtgaccaa gagcttcaac aggggcgagt gc 642 <210> 163 <211> 10 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 163 Ser Arg Leu Ile Ala Pro Trp Leu Asp Tyr 1 5 10 <210> 164 <211> 12 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 164 Ala Arg Ser Arg Leu Ile Ala Pro Trp Leu Asp Tyr 1 5 10 <210> 165 <211> 119 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 165 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ser Arg Leu Ile Ala Pro Trp Leu Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 166 <211> 357 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 166 gaagttcagc tgctggaatc tggcggagga ctggttcaac ctggcggctc tctgagactg 60 tcttgtgccg ccagcggctt cacctttagc agctacgcca tgagctgggt ccgacaggct 120 cctggcaaag gccttgaatg ggtgtccgcc atctctggct ctggcggcag cacatattac 180 gccgactctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac 240 ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagaagcaga 300 ctgatcgccc cttggctgga ttattggggc cagggcacac tggtcaccgt gtcatct 357 <210> 167 <211> 449 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 167 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ser Arg Leu Ile Ala Pro Trp Leu Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 115 120 125 Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 130 135 140 Gly Cys Leu Val Lys Asp Tyr Phe Pro Cys Pro Val Thr Val Ser Trp 145 150 155 160 Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 165 170 175 Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 180 185 190 Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 195 200 205 Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 210 215 220 Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 225 230 235 240 Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 245 250 255 Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 260 265 270 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 275 280 285 Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 290 295 300 Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 305 310 315 320 Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 325 330 335 Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 340 345 350 Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 355 360 365 Cys Leu Val Lys Gly Phe Tyr Pro Cys Asp Ile Ala Val Glu Trp Glu 370 375 380 Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 385 390 395 400 Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 405 410 415 Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 420 425 430 Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 435 440 445 Lys <210> 168 <211> 1347 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 168 gaagttcagc tgctggaatc tggcggagga ctggttcaac ctggcggctc tctgagactg 60 tcttgtgccg ccagcggctt cacctttagc agctacgcca tgagctgggt ccgacaggct 120 cctggcaaag gccttgaatg ggtgtccgcc atctctggct ctggcggcag cacatattac 180 gccgactctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac 240 ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagaagcaga 300 ctgatcgccc cttggctgga ttattggggc cagggcacac tggtcaccgt gtcatctgct 360 agcaccaagg gcccaagtgt gtttcccctg gcccccagca gcaagtctac ttccggcgga 420 actgctgccc tgggttgcct ggtgaaggac tacttcccct gtcccgtgac agtgtcctgg 480 aactctgggg ctctgacttc cggcgtgcac accttccccg ccgtgctgca gagcagcggc 540 ctgtacagcc tgagcagcgt ggtgacagtg ccctccagct ctctgggaac ccagacctat 600 atctgcaacg tgaaccacaa gcccagcaac accaaggtgg acaagagagt ggagcccaag 660 agctgcgaca agacccacac ctgccccccc tgcccagctc cagaactgct gggagggcct 720 tccgtgttcc tgttcccccc caagcccaag gacaccctga tgatcagcag gacccccgag 780 gtgacctgcg tggtggtgga cgtgtcccac gaggacccag aggtgaagtt caactggtac 840 gtggacggcg tggaggtgca caacgccaag accaagccca gagaggagca gtacaacagc 900 acctacaggg tggtgtccgt gctgaccgtg ctgcaccagg actggctgaa cggcaaagaa 960 tacaagtgca aagtctccaa caaggccctg ccagccccaa tcgaaaagac aatcagcaag 1020 gccaagggcc agccacggga gccccaggtg tacaccctgc cccccagccg ggaggagatg 1080 accaagaacc aggtgtccct gacctgtctg gtgaagggct tctacccctg tgatatcgcc 1140 gtggagtggg agagcaacgg ccagcccgag aacaactaca agaccacccc cccagtgctg 1200 gacagcgacg gcagcttctt cctgtacagc aagctgaccg tggacaagtc caggtggcag 1260 cagggcaacg tgttcagctg cagcgtgatg cacgaggccc tgcacaacca ctacacccag 1320 aagtccctga gcctgagccc cggcaag 1347 <210> 169 <211> 9 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 169 Gln Gln Val Tyr Gly Ser Pro Pro Thr 1 5 <210> 170 <211> 6 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 170 Val Tyr Gly Ser Pro Pro 1 5 <210> 171 <211> 107 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 171 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Tyr Gly Ser Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 172 <211> 321 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 172 gacatccaga tgacacagag ccctagcagc ctgtctgcca gcgtgggaga cagagtgacc 60 atcacctgta gagccagcca gagcatcagc agctacctga actggtatca gcagaagccc 120 ggcaaggccc ctaaactgct gatctatgcc gccagctctc tgcagtctgg cgtgccaagc 180 agattttctg gcagcggctc tggcaccgac ttcaccctga ccatatctag cctgcagcca 240 gaggacttcg ccacctacta ctgccagcag gtctacggca gccctcctac atttggccag 300 ggcaccaagg tggaaatcaa g 321 <210> 173 <211> 214 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 173 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Tyr Gly Ser Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 100 105 110 Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 115 120 125 Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 130 135 140 Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 145 150 155 160 Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 165 170 175 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 180 185 190 Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 195 200 205 Phe Asn Arg Gly Glu Cys 210 <210> 174 <211> 642 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 174 gacatccaga tgacacagag ccctagcagc ctgtctgcca gcgtgggaga cagagtgacc 60 atcacctgta gagccagcca gagcatcagc agctacctga actggtatca gcagaagccc 120 ggcaaggccc ctaaactgct gatctatgcc gccagctctc tgcagtctgg cgtgccaagc 180 agattttctg gcagcggctc tggcaccgac ttcaccctga ccatatctag cctgcagcca 240 gaggacttcg ccacctacta ctgccagcag gtctacggca gccctcctac atttggccag 300 ggcaccaagg tggaaatcaa gcgtacggtg gccgctccca gcgtgttcat cttccccccc 360 agcgacgagc agctgaagag tggcaccgcc agcgtggtgt gcctgctgaa caacttctac 420 ccccgggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag 480 gagagcgtca ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc 540 ctgagcaagg ccgactacga gaagcataag gtgtacgcct gcgaggtgac ccaccagggc 600 ctgtccagcc ccgtgaccaa gagcttcaac aggggcgagt gc 642 <210> 175 <211> 10 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 175 Gly Tyr Ser Phe Thr Ser Tyr Trp Ile Gly 1 5 10 <210> 176 <211> 17 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 176 Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 1 5 10 15 Gly <210> 177 <211> 12 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 177 Gly Ser Ser Ala Ala Ser Gly Leu Ser Gly Asp Leu 1 5 10 <210> 178 <211> 5 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 178 Ser Tyr Trp Ile Gly 1 5 <210> 179 <211> 7 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 179 Gly Tyr Ser Phe Thr Ser Tyr 1 5 <210> 180 <211> 6 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 180 Tyr Pro Gly Asp Ser Asp 1 5 <210> 181 <211> 8 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 181 Gly Tyr Ser Phe Thr Ser Tyr Trp 1 5 <210> 182 <211> 8 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 182 Ile Tyr Pro Gly Asp Ser Asp Thr 1 5 <210> 183 <211> 14 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 183 Ala Arg Gly Ser Ser Ala Ala Ser Gly Leu Ser Gly Asp Leu 1 5 10 <210> 184 <211> 121 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 184 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 20 25 30 Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Ala Arg Gly Ser Ser Ala Ala Ser Gly Leu Ser Gly Asp Leu Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 185 <211> 363 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 185 gaagttcagc tggtgcagtc tggcgccgaa gtgaagaagc ctggcgagag cctgaagatc 60 tcctgcaaag gcagcggcta cagcttcacc agctactgga tcggctgggt ccgacagatg 120 cctggcaaag gccttgagtg gatgggcatc atctaccccg gcgacagcga caccagatac 180 agccctagct ttcagggcca agtgaccatc agcgccgaca agagcatcag cacagcctac 240 ctgcagtggt ccagcctgaa ggcctctgac accgccatgt actactgtgc cagaggaagc 300 tctgccgcct ctggactgtc tggcgatctt tggggacagg gcacactggt cacagtgtct 360 agt 363 <210> 186 <211> 451 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 186 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 20 25 30 Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Ala Arg Gly Ser Ser Ala Ala Ser Gly Leu Ser Gly Asp Leu Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 115 120 125 Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 130 135 140 Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Cys Pro Val Thr Val 145 150 155 160 Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 165 170 175 Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 180 185 190 Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 195 200 205 Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 210 215 220 Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 225 230 235 240 Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 245 250 255 Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 260 265 270 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 275 280 285 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 290 295 300 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 305 310 315 320 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 325 330 335 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 340 345 350 Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 355 360 365 Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Cys Asp Ile Ala Val Glu 370 375 380 Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 385 390 395 400 Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 405 410 415 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 420 425 430 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 435 440 445 Pro Gly Lys 450 <210> 187 <211> 1353 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 187 gaagttcagc tggtgcagtc tggcgccgaa gtgaagaagc ctggcgagag cctgaagatc 60 tcctgcaaag gcagcggcta cagcttcacc agctactgga tcggctgggt ccgacagatg 120 cctggcaaag gccttgagtg gatgggcatc atctaccccg gcgacagcga caccagatac 180 agccctagct ttcagggcca agtgaccatc agcgccgaca agagcatcag cacagcctac 240 ctgcagtggt ccagcctgaa ggcctctgac accgccatgt actactgtgc cagaggaagc 300 tctgccgcct ctggactgtc tggcgatctt tggggacagg gcacactggt cacagtgtct 360 agtgctagca ccaagggccc aagtgtgttt cccctggccc ccagcagcaa gtctacttcc 420 ggcggaactg ctgccctggg ttgcctggtg aaggactact tcccctgtcc cgtgacagtg 480 tcctggaact ctggggctct gacttccggc gtgcacacct tccccgccgt gctgcagagc 540 agcggcctgt acagcctgag cagcgtggtg acagtgccct ccagctctct gggaacccag 600 acctatatct gcaacgtgaa ccacaagccc agcaacacca aggtggacaa gagagtggag 660 cccaagagct gcgacaagac ccacacctgc cccccctgcc cagctccaga actgctggga 720 gggccttccg tgttcctgtt cccccccaag cccaaggaca ccctgatgat cagcaggacc 780 cccgaggtga cctgcgtggt ggtggacgtg tcccacgagg acccagaggt gaagttcaac 840 tggtacgtgg acggcgtgga ggtgcacaac gccaagacca agcccagaga ggagcagtac 900 aacagcacct acagggtggt gtccgtgctg accgtgctgc accaggactg gctgaacggc 960 aaagaataca agtgcaaagt ctccaacaag gccctgccag ccccaatcga aaagacaatc 1020 agcaaggcca agggccagcc acgggagccc caggtgtaca ccctgccccc cagccgggag 1080 gagatgacca agaaccaggt gtccctgacc tgtctggtga agggcttcta cccctgtgat 1140 atcgccgtgg agtgggagag caacggccag cccgagaaca actacaagac caccccccca 1200 gtgctggaca gcgacggcag cttcttcctg tacagcaagc tgaccgtgga caagtccagg 1260 tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caaccactac 1320 acccagaagt ccctgagcct gagccccggc aag 1353 <210> 188 <211> 9 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 188 Gln Gln Asp Tyr Tyr Ser Pro Phe Thr 1 5 <210> 189 <211> 6 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 189 Asp Tyr Tyr Ser Pro Phe 1 5 <210> 190 <211> 107 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 190 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asp Tyr Tyr Ser Pro Phe 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 191 <211> 321 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 191 gacatccaga tgacacagag ccctagcagc ctgtctgcca gcgtgggaga cagagtgacc 60 atcacctgta gagccagcca gagcatcagc agctacctga actggtatca gcagaagccc 120 ggcaaggccc ctaaactgct gatctatgcc gccagctctc tgcagtctgg cgtgccaagc 180 agattttctg gcagcggctc tggcaccgac ttcaccctga ccatatctag cctgcagcca 240 gaggacttcg ccacctacta ctgccagcag gactactaca gccccttcac ctttggccag 300 ggcaccaagg tggaaatcaa g 321 <210> 192 <211> 214 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 192 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asp Tyr Tyr Ser Pro Phe 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 100 105 110 Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 115 120 125 Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 130 135 140 Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 145 150 155 160 Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 165 170 175 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 180 185 190 Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 195 200 205 Phe Asn Arg Gly Glu Cys 210 <210> 193 <211> 642 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 193 gacatccaga tgacacagag ccctagcagc ctgtctgcca gcgtgggaga cagagtgacc 60 atcacctgta gagccagcca gagcatcagc agctacctga actggtatca gcagaagccc 120 ggcaaggccc ctaaactgct gatctatgcc gccagctctc tgcagtctgg cgtgccaagc 180 agattttctg gcagcggctc tggcaccgac ttcaccctga ccatatctag cctgcagcca 240 gaggacttcg ccacctacta ctgccagcag gactactaca gccccttcac ctttggccag 300 ggcaccaagg tggaaatcaa gcgtacggtg gccgctccca gcgtgttcat cttccccccc 360 agcgacgagc agctgaagag tggcaccgcc agcgtggtgt gcctgctgaa caacttctac 420 ccccgggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag 480 gagagcgtca ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc 540 ctgagcaagg ccgactacga gaagcataag gtgtacgcct gcgaggtgac ccaccagggc 600 ctgtccagcc ccgtgaccaa gagcttcaac aggggcgagt gc 642 <210> 194 <211> 9 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 194 Ala Tyr Lys Leu Ser Trp Leu Asp Leu 1 5 <210> 195 <211> 11 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 195 Ala Arg Ala Tyr Lys Leu Ser Trp Leu Asp Leu 1 5 10 <210> 196 <211> 118 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 196 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ala Tyr Lys Leu Ser Trp Leu Asp Leu Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 197 <211> 354 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 197 gaagttcagc tgctggaatc tggcggagga ctggttcaac ctggcggctc tctgagactg 60 tcttgtgccg ccagcggctt cacctttagc agctacgcca tgagctgggt ccgacaggct 120 cctggcaaag gccttgaatg ggtgtccgcc atctctggct ctggcggcag cacatattac 180 gccgactctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac 240 ctgcagatga acagcctgag agccgaggac accgccgtgt actattgtgc cagagcctac 300 aagctgagct ggctggatct ttggggccag ggcacactgg tcacagtgtc atct 354 <210> 198 <211> 448 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 198 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ala Tyr Lys Leu Ser Trp Leu Asp Leu Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 115 120 125 Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 130 135 140 Cys Leu Val Lys Asp Tyr Phe Pro Cys Pro Val Thr Val Ser Trp Asn 145 150 155 160 Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 165 170 175 Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 180 185 190 Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 195 200 205 Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 210 215 220 His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 225 230 235 240 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 245 250 255 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 260 265 270 Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 275 280 285 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 290 295 300 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 305 310 315 320 Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 325 330 335 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 340 345 350 Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 355 360 365 Leu Val Lys Gly Phe Tyr Pro Cys Asp Ile Ala Val Glu Trp Glu Ser 370 375 380 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 385 390 395 400 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 405 410 415 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 420 425 430 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 435 440 445 <210> 199 <211> 1344 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 199 gaagttcagc tgctggaatc tggcggagga ctggttcaac ctggcggctc tctgagactg 60 tcttgtgccg ccagcggctt cacctttagc agctacgcca tgagctgggt ccgacaggct 120 cctggcaaag gccttgaatg ggtgtccgcc atctctggct ctggcggcag cacatattac 180 gccgactctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac 240 ctgcagatga acagcctgag agccgaggac accgccgtgt actattgtgc cagagcctac 300 aagctgagct ggctggatct ttggggccag ggcacactgg tcacagtgtc atctgctagc 360 accaagggcc caagtgtgtt tcccctggcc cccagcagca agtctacttc cggcggaact 420 gctgccctgg gttgcctggt gaaggactac ttcccctgtc ccgtgacagt gtcctggaac 480 tctggggctc tgacttccgg cgtgcacacc ttccccgccg tgctgcagag cagcggcctg 540 tacagcctga gcagcgtggt gacagtgccc tccagctctc tgggaaccca gacctatatc 600 tgcaacgtga accacaagcc cagcaacacc aaggtggaca agagagtgga gcccaagagc 660 tgcgacaaga cccacacctg ccccccctgc ccagctccag aactgctggg agggccttcc 720 gtgttcctgt tcccccccaa gcccaaggac accctgatga tcagcaggac ccccgaggtg 780 acctgcgtgg tggtggacgt gtcccacgag gacccagagg tgaagttcaa ctggtacgtg 840 gacggcgtgg aggtgcacaa cgccaagacc aagcccagag aggagcagta caacagcacc 900 tacagggtgg tgtccgtgct gaccgtgctg caccaggact ggctgaacgg caaagaatac 960 aagtgcaaag tctccaacaa ggccctgcca gccccaatcg aaaagacaat cagcaaggcc 1020 aagggccagc cacgggagcc ccaggtgtac accctgcccc ccagccggga ggagatgacc 1080 aagaaccagg tgtccctgac ctgtctggtg aagggcttct acccctgtga tatcgccgtg 1140 gagtgggaga gcaacggcca gcccgagaac aactacaaga ccaccccccc agtgctggac 1200 agcgacggca gcttcttcct gtacagcaag ctgaccgtgg acaagtccag gtggcagcag 1260 ggcaacgtgt tcagctgcag cgtgatgcac gaggccctgc acaaccacta cacccagaag 1320 tccctgagcc tgagccccgg caag 1344 <210> 200 <211> 9 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 200 Gln Gln Val Trp Tyr Ala Pro Val Thr 1 5 <210> 201 <211> 6 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 201 Val Trp Tyr Ala Pro Val 1 5 <210> 202 <211> 107 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 202 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Trp Tyr Ala Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 203 <211> 321 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 203 gacatccaga tgacacagag ccctagcagc ctgtctgcca gcgtgggaga cagagtgacc 60 atcacctgta gagccagcca gagcatcagc agctacctga actggtatca gcagaagccc 120 ggcaaggccc ctaaactgct gatctatgcc gccagctctc tgcagtctgg cgtgccaagc 180 agattttctg gcagcggctc tggcaccgac ttcaccctga ccatatctag cctgcagcca 240 gaggacttcg ccacctacta ctgccagcaa gtttggtacg cccctgtgac ctttggccag 300 ggcaccaagg tggaaatcaa g 321 <210> 204 <211> 214 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 204 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Trp Tyr Ala Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 100 105 110 Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 115 120 125 Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 130 135 140 Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 145 150 155 160 Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 165 170 175 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 180 185 190 Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 195 200 205 Phe Asn Arg Gly Glu Cys 210 <210> 205 <211> 642 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 205 gacatccaga tgacacagag ccctagcagc ctgtctgcca gcgtgggaga cagagtgacc 60 atcacctgta gagccagcca gagcatcagc agctacctga actggtatca gcagaagccc 120 ggcaaggccc ctaaactgct gatctatgcc gccagctctc tgcagtctgg cgtgccaagc 180 agattttctg gcagcggctc tggcaccgac ttcaccctga ccatatctag cctgcagcca 240 gaggacttcg ccacctacta ctgccagcaa gtttggtacg cccctgtgac ctttggccag 300 ggcaccaagg tggaaatcaa gcgtacggtg gccgctccca gcgtgttcat cttccccccc 360 agcgacgagc agctgaagag tggcaccgcc agcgtggtgt gcctgctgaa caacttctac 420 ccccgggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag 480 gagagcgtca ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc 540 ctgagcaagg ccgactacga gaagcataag gtgtacgcct gcgaggtgac ccaccagggc 600 ctgtccagcc ccgtgaccaa gagcttcaac aggggcgagt gc 642 <210> 206 <211> 10 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 206 Gly Phe Thr Phe Ser Asn Ala Trp Met Ser 1 5 10 <210> 207 <211> 19 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 207 Arg Ile Lys Ser Lys Thr Asp Ala Gly Thr Thr Asp Tyr Ala Ala Pro 1 5 10 15 Val Lys Gly <210> 208 <211> 13 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 208 Thr Ile Tyr Pro Ser Ala Pro Ser Ser Ser Leu Asp Tyr 1 5 10 <210> 209 <211> 5 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 209 Asn Ala Trp Met Ser 1 5 <210> 210 <211> 7 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 210 Gly Phe Thr Phe Ser Asn Ala 1 5 <210> 211 <211> 8 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 211 Lys Ser Lys Thr Asp Ala Gly Thr 1 5 <210> 212 <211> 8 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 212 Gly Phe Thr Phe Ser Asn Ala Trp 1 5 <210> 213 <211> 10 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 213 Ile Lys Ser Lys Thr Asp Ala Gly Thr Thr 1 5 10 <210> 214 <211> 15 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 214 Ala Arg Thr Ile Tyr Pro Ser Ala Pro Ser Ser Ser Leu Asp Tyr 1 5 10 15 <210> 215 <211> 124 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 215 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Arg Ile Lys Ser Lys Thr Asp Ala Gly Thr Thr Asp Tyr Ala Ala 50 55 60 Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Ala Arg Thr Ile Tyr Pro Ser Ala Pro Ser Ser Ser Leu Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 216 <211> 372 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 216 gaagtgcagc tggtggaatc tggcggcgga cttgtgaaac ctggcggctc tctgagactg 60 agctgtgccg cttccggctt caccttcagc aatgcctgga tgagctgggt ccgacaggcc 120 cctggaaaag gccttgagtg ggtcggacgg atcaagagca agaccgatgc cggcaccacc 180 gattatgctg cccctgtgaa gggcagattc accatcagca gggacgacag caagaacacc 240 ctgtacctgc agatgaacag cctgaaaacc gaggacaccg ccgtgtacta ctgcgccaga 300 acaatctacc ccagcgctcc tagcagcagc ctggattatt ggggccaggg cacactggtc 360 accgtgtcat ct 372 <210> 217 <211> 454 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 217 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Arg Ile Lys Ser Lys Thr Asp Ala Gly Thr Thr Asp Tyr Ala Ala 50 55 60 Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Ala Arg Thr Ile Tyr Pro Ser Ala Pro Ser Ser Ser Leu Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 115 120 125 Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 130 135 140 Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Cys Pro 145 150 155 160 Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 165 170 175 Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 180 185 190 Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 195 200 205 Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 210 215 220 Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 225 230 235 240 Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 245 250 255 Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 260 265 270 Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 275 280 285 Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 290 295 300 Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 305 310 315 320 Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 325 330 335 Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 340 345 350 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 355 360 365 Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Cys Asp Ile 370 375 380 Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 385 390 395 400 Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 405 410 415 Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 420 425 430 Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 435 440 445 Ser Leu Ser Pro Gly Lys 450 <210> 218 <211> 1362 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 218 gaagtgcagc tggtggaatc tggcggcgga cttgtgaaac ctggcggctc tctgagactg 60 agctgtgccg cttccggctt caccttcagc aatgcctgga tgagctgggt ccgacaggcc 120 cctggaaaag gccttgagtg ggtcggacgg atcaagagca agaccgatgc cggcaccacc 180 gattatgctg cccctgtgaa gggcagattc accatcagca gggacgacag caagaacacc 240 ctgtacctgc agatgaacag cctgaaaacc gaggacaccg ccgtgtacta ctgcgccaga 300 acaatctacc ccagcgctcc tagcagcagc ctggattatt ggggccaggg cacactggtc 360 accgtgtcat ctgctagcac caagggccca agtgtgtttc ccctggcccc cagcagcaag 420 tctacttccg gcggaactgc tgccctgggt tgcctggtga aggactactt cccctgtccc 480 gtgacagtgt cctggaactc tggggctctg acttccggcg tgcacacctt ccccgccgtg 540 ctgcagagca gcggcctgta cagcctgagc agcgtggtga cagtgccctc cagctctctg 600 ggaacccaga cctatatctg caacgtgaac cacaagccca gcaacaccaa ggtggacaag 660 agagtggagc ccaagagctg cgacaagacc cacacctgcc ccccctgccc agctccagaa 720 ctgctgggag ggccttccgt gttcctgttc ccccccaagc ccaaggacac cctgatgatc 780 agcaggaccc ccgaggtgac ctgcgtggtg gtggacgtgt cccacgagga cccagaggtg 840 aagttcaact ggtacgtgga cggcgtggag gtgcacaacg ccaagaccaa gcccagagag 900 gagcagtaca acagcaccta cagggtggtg tccgtgctga ccgtgctgca ccaggactgg 960 ctgaacggca aagaatacaa gtgcaaagtc tccaacaagg ccctgccagc cccaatcgaa 1020 aagacaatca gcaaggccaa gggccagcca cgggagcccc aggtgtacac cctgcccccc 1080 agccgggagg agatgaccaa gaaccaggtg tccctgacct gtctggtgaa gggcttctac 1140 ccctgtgata tcgccgtgga gtgggagagc aacggccagc ccgagaacaa ctacaagacc 1200 acccccccag tgctggacag cgacggcagc ttcttcctgt acagcaagct gaccgtggac 1260 aagtccaggt ggcagcaggg caacgtgttc agctgcagcg tgatgcacga ggccctgcac 1320 aaccactaca cccagaagtc cctgagcctg agccccggca ag 1362 <210> 219 <211> 9 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 219 Gln Gln Leu Ile Phe Phe Pro Leu Thr 1 5 <210> 220 <211> 6 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 220 Leu Ile Phe Phe Pro Leu 1 5 <210> 221 <211> 107 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 221 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Leu Ile Phe Phe Pro Leu 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 222 <211> 321 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 222 gacatccaga tgacacagag ccctagcagc ctgtctgcca gcgtgggaga cagagtgacc 60 atcacctgta gagccagcca gggcatcagc aactacctgg cctggtatca gcagaaaccc 120 ggcaaggtgc ccaagctgct gatctacgct gccagcacac tgcagagcgg agtgcctagc 180 agattttctg gcagcggctc cggcaccgat ttcaccctga ccatatctag cctgcagcca 240 gaggacgtgg ccacctacta ttgccagcag ctgatcttct tccctctgac ctttggccag 300 ggcaccaagg tggaaatcaa g 321 <210> 223 <211> 214 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 223 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Leu Ile Phe Phe Pro Leu 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 100 105 110 Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 115 120 125 Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 130 135 140 Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 145 150 155 160 Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 165 170 175 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 180 185 190 Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 195 200 205 Phe Asn Arg Gly Glu Cys 210 <210> 224 <211> 642 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 224 gacatccaga tgacacagag ccctagcagc ctgtctgcca gcgtgggaga cagagtgacc 60 atcacctgta gagccagcca gggcatcagc aactacctgg cctggtatca gcagaaaccc 120 ggcaaggtgc ccaagctgct gatctacgct gccagcacac tgcagagcgg agtgcctagc 180 agattttctg gcagcggctc cggcaccgat ttcaccctga ccatatctag cctgcagcca 240 gaggacgtgg ccacctacta ttgccagcag ctgatcttct tccctctgac ctttggccag 300 ggcaccaagg tggaaatcaa gcgtacggtg gccgctccca gcgtgttcat cttccccccc 360 agcgacgagc agctgaagag tggcaccgcc agcgtggtgt gcctgctgaa caacttctac 420 ccccgggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag 480 gagagcgtca ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc 540 ctgagcaagg ccgactacga gaagcataag gtgtacgcct gcgaggtgac ccaccagggc 600 ctgtccagcc ccgtgaccaa gagcttcaac aggggcgagt gc 642 <210> 225 <211> 11 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 225 Ala Ser His Arg Leu His Ser Leu Phe Asp Val 1 5 10 <210> 226 <211> 13 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 226 Ala Arg Ala Ser His Arg Leu His Ser Leu Phe Asp Val 1 5 10 <210> 227 <211> 122 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 227 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Arg Ile Lys Ser Lys Thr Asp Ala Gly Thr Thr Asp Tyr Ala Ala 50 55 60 Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Ala Arg Ala Ser His Arg Leu His Ser Leu Phe Asp Val Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 228 <211> 366 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 228 gaagtgcagc tggtggaatc tggcggcgga cttgtgaaac ctggcggctc tctgagactg 60 agctgtgccg cttccggctt caccttcagc aatgcctgga tgagctgggt ccgacaggcc 120 cctggaaaag gccttgagtg ggtcggacgg atcaagagca agaccgatgc cggcaccacc 180 gattatgctg cccctgtgaa gggcagattc accatcagca gggacgacag caagaacacc 240 ctgtacctgc agatgaacag cctgaaaacc gaggacaccg ccgtgtacta ctgtgccaga 300 gcctctcaca gactgcacag cctgtttgac gtgtggggcc agggaacact ggtcaccgtt 360 agttct 366 <210> 229 <211> 452 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 229 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Arg Ile Lys Ser Lys Thr Asp Ala Gly Thr Thr Asp Tyr Ala Ala 50 55 60 Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Ala Arg Ala Ser His Arg Leu His Ser Leu Phe Asp Val Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 115 120 125 Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 130 135 140 Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Cys Pro Val Thr 145 150 155 160 Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 165 170 175 Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 180 185 190 Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 195 200 205 His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 210 215 220 Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 225 230 235 240 Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 245 250 255 Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 260 265 270 His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 275 280 285 Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 290 295 300 Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 305 310 315 320 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 325 330 335 Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 340 345 350 Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 355 360 365 Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Cys Asp Ile Ala Val 370 375 380 Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 385 390 395 400 Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 405 410 415 Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 420 425 430 Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 435 440 445 Ser Pro Gly Lys 450 <210> 230 <211> 1356 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 230 gaagtgcagc tggtggaatc tggcggcgga cttgtgaaac ctggcggctc tctgagactg 60 agctgtgccg cttccggctt caccttcagc aatgcctgga tgagctgggt ccgacaggcc 120 cctggaaaag gccttgagtg ggtcggacgg atcaagagca agaccgatgc cggcaccacc 180 gattatgctg cccctgtgaa gggcagattc accatcagca gggacgacag caagaacacc 240 ctgtacctgc agatgaacag cctgaaaacc gaggacaccg ccgtgtacta ctgtgccaga 300 gcctctcaca gactgcacag cctgtttgac gtgtggggcc agggaacact ggtcaccgtt 360 agttctgcta gcaccaaggg cccaagtgtg tttcccctgg cccccagcag caagtctact 420 tccggcggaa ctgctgccct gggttgcctg gtgaaggact acttcccctg tcccgtgaca 480 gtgtcctgga actctggggc tctgacttcc ggcgtgcaca ccttccccgc cgtgctgcag 540 agcagcggcc tgtacagcct gagcagcgtg gtgacagtgc cctccagctc tctgggaacc 600 cagacctata tctgcaacgt gaaccacaag cccagcaaca ccaaggtgga caagagagtg 660 gagcccaaga gctgcgacaa gacccacacc tgccccccct gcccagctcc agaactgctg 720 ggagggcctt ccgtgttcct gttccccccc aagcccaagg acaccctgat gatcagcagg 780 acccccgagg tgacctgcgt ggtggtggac gtgtcccacg aggacccaga ggtgaagttc 840 aactggtacg tggacggcgt ggaggtgcac aacgccaaga ccaagcccag agaggagcag 900 tacaacagca cctacagggt ggtgtccgtg ctgaccgtgc tgcaccagga ctggctgaac 960 ggcaaagaat acaagtgcaa agtctccaac aaggccctgc cagccccaat cgaaaagaca 1020 atcagcaagg ccaagggcca gccacgggag ccccaggtgt acaccctgcc ccccagccgg 1080 gaggagatga ccaagaacca ggtgtccctg acctgtctgg tgaagggctt ctacccctgt 1140 gatatcgccg tggagtggga gagcaacggc cagcccgaga acaactacaa gaccaccccc 1200 ccagtgctgg acagcgacgg cagcttcttc ctgtacagca agctgaccgt ggacaagtcc 1260 aggtggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac 1320 tacacccaga agtccctgag cctgagcccc ggcaag 1356 <210> 231 <211> 9 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 231 Gln Gln Gly Leu Phe Tyr Pro His Thr 1 5 <210> 232 <211> 6 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 232 Gly Leu Phe Tyr Pro His 1 5 <210> 233 <211> 107 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 233 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Leu Phe Tyr Pro His 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 234 <211> 321 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 234 gacatccaga tgacacagag ccccagcaca ctgtctgcca gcgtgggaga cagagtgacc 60 atcacctgta gagccagcca gagcatctcc tcttggctgg cctggtatca gcagaagcct 120 ggcaaggccc ctaagctgct gatctacgat gccagcagcc tggaaagcgg cgtgccaagc 180 agattttctg gcagcggctc tggcaccgag ttcaccctga ccatatctag cctgcagcca 240 gaggacttcg ccacctacta ttgtcagcag ggcctgttct accctcacac ctttggccag 300 ggcaccaagg tggaaatcaa g 321 <210> 235 <211> 214 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 235 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Leu Phe Tyr Pro His 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 100 105 110 Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 115 120 125 Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 130 135 140 Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 145 150 155 160 Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 165 170 175 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 180 185 190 Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 195 200 205 Phe Asn Arg Gly Glu Cys 210 <210> 236 <211> 642 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 236 gacatccaga tgacacagag ccccagcaca ctgtctgcca gcgtgggaga cagagtgacc 60 atcacctgta gagccagcca gagcatctcc tcttggctgg cctggtatca gcagaagcct 120 ggcaaggccc ctaagctgct gatctacgat gccagcagcc tggaaagcgg cgtgccaagc 180 agattttctg gcagcggctc tggcaccgag ttcaccctga ccatatctag cctgcagcca 240 gaggacttcg ccacctacta ttgtcagcag ggcctgttct accctcacac ctttggccag 300 ggcaccaagg tggaaatcaa gcgtacggtg gccgctccca gcgtgttcat cttccccccc 360 agcgacgagc agctgaagag tggcaccgcc agcgtggtgt gcctgctgaa caacttctac 420 ccccgggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag 480 gagagcgtca ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc 540 ctgagcaagg ccgactacga gaagcataag gtgtacgcct gcgaggtgac ccaccagggc 600 ctgtccagcc ccgtgaccaa gagcttcaac aggggcgagt gc 642 <210> 237 <211> 10 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 237 Asp Glu Tyr Pro Trp Gly Trp Phe Asp Val 1 5 10 <210> 238 <211> 12 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 238 Ala Arg Asp Glu Tyr Pro Trp Gly Trp Phe Asp Val 1 5 10 <210> 239 <211> 121 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 239 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Arg Ile Lys Ser Lys Thr Asp Ala Gly Thr Thr Asp Tyr Ala Ala 50 55 60 Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Ala Arg Asp Glu Tyr Pro Trp Gly Trp Phe Asp Val Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 240 <211> 363 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 240 gaagtgcagc tggtggaatc tggcggcgga cttgtgaaac ctggcggctc tctgagactg 60 agctgtgccg cttccggctt caccttcagc aatgcctgga tgagctgggt ccgacaggcc 120 cctggaaaag gccttgagtg ggtcggacgg atcaagagca agaccgatgc cggcaccacc 180 gattatgctg cccctgtgaa gggcagattc accatcagca gggacgacag caagaacacc 240 ctgtacctgc agatgaacag cctgaaaacc gaggacaccg ccgtgtacta ctgcgccaga 300 gatgagtacc cctggggatg gttcgatgtg tggggacagg gaaccctggt caccgttagt 360 tct 363 <210> 241 <211> 451 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 241 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Arg Ile Lys Ser Lys Thr Asp Ala Gly Thr Thr Asp Tyr Ala Ala 50 55 60 Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Ala Arg Asp Glu Tyr Pro Trp Gly Trp Phe Asp Val Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 115 120 125 Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 130 135 140 Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Cys Pro Val Thr Val 145 150 155 160 Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 165 170 175 Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 180 185 190 Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 195 200 205 Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 210 215 220 Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 225 230 235 240 Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 245 250 255 Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 260 265 270 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 275 280 285 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 290 295 300 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 305 310 315 320 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 325 330 335 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 340 345 350 Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 355 360 365 Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Cys Asp Ile Ala Val Glu 370 375 380 Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 385 390 395 400 Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 405 410 415 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 420 425 430 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 435 440 445 Pro Gly Lys 450 <210> 242 <211> 1353 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 242 gaagtgcagc tggtggaatc tggcggcgga cttgtgaaac ctggcggctc tctgagactg 60 agctgtgccg cttccggctt caccttcagc aatgcctgga tgagctgggt ccgacaggcc 120 cctggaaaag gccttgagtg ggtcggacgg atcaagagca agaccgatgc cggcaccacc 180 gattatgctg cccctgtgaa gggcagattc accatcagca gggacgacag caagaacacc 240 ctgtacctgc agatgaacag cctgaaaacc gaggacaccg ccgtgtacta ctgcgccaga 300 gatgagtacc cctggggatg gttcgatgtg tggggacagg gaaccctggt caccgttagt 360 tctgctagca ccaagggccc aagtgtgttt cccctggccc ccagcagcaa gtctacttcc 420 ggcggaactg ctgccctggg ttgcctggtg aaggactact tcccctgtcc cgtgacagtg 480 tcctggaact ctggggctct gacttccggc gtgcacacct tccccgccgt gctgcagagc 540 agcggcctgt acagcctgag cagcgtggtg acagtgccct ccagctctct gggaacccag 600 acctatatct gcaacgtgaa ccacaagccc agcaacacca aggtggacaa gagagtggag 660 cccaagagct gcgacaagac ccacacctgc cccccctgcc cagctccaga actgctggga 720 gggccttccg tgttcctgtt cccccccaag cccaaggaca ccctgatgat cagcaggacc 780 cccgaggtga cctgcgtggt ggtggacgtg tcccacgagg acccagaggt gaagttcaac 840 tggtacgtgg acggcgtgga ggtgcacaac gccaagacca agcccagaga ggagcagtac 900 aacagcacct acagggtggt gtccgtgctg accgtgctgc accaggactg gctgaacggc 960 aaagaataca agtgcaaagt ctccaacaag gccctgccag ccccaatcga aaagacaatc 1020 agcaaggcca agggccagcc acgggagccc caggtgtaca ccctgccccc cagccgggag 1080 gagatgacca agaaccaggt gtccctgacc tgtctggtga agggcttcta cccctgtgat 1140 atcgccgtgg agtgggagag caacggccag cccgagaaca actacaagac caccccccca 1200 gtgctggaca gcgacggcag cttcttcctg tacagcaagc tgaccgtgga caagtccagg 1260 tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caaccactac 1320 acccagaagt ccctgagcct gagccccggc aag 1353 <210> 243 <211> 11 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 243 Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 1 5 10 <210> 244 <211> 9 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 244 Gln Gln Tyr Ile Phe Tyr Pro Leu Thr 1 5 <210> 245 <211> 7 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 245 Ser Gln Gly Ile Ser Ser Trp 1 5 <210> 246 <211> 6 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 246 Tyr Ile Phe Tyr Pro Leu 1 5 <210> 247 <211> 6 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 247 Gln Gly Ile Ser Ser Trp 1 5 <210> 248 <211> 107 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 248 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ile Phe Tyr Pro Leu 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 249 <211> 321 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 249 gacatccaga tgacacagag ccctagctcc gtgtctgcca gcgtgggaga cagagtgacc 60 atcacctgta gagccagcca gggcatctct tcttggctgg cctggtatca gcagaagcct 120 ggcaaggccc ctaagctgct gatctatgcc gcttccagtc tgcagagcgg cgtgccaagc 180 agattttctg gcagcggctc tggcaccgac ttcaccctga ccatatctag cctgcagcca 240 gaggacttcg ccacctacta ctgccagcag tacatcttct accctctgac cttcggccag 300 ggcaccaagg tggaaatcaa g 321 <210> 250 <211> 214 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 250 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ile Phe Tyr Pro Leu 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 100 105 110 Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 115 120 125 Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 130 135 140 Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 145 150 155 160 Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 165 170 175 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 180 185 190 Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 195 200 205 Phe Asn Arg Gly Glu Cys 210 <210> 251 <211> 642 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 251 gacatccaga tgacacagag ccctagctcc gtgtctgcca gcgtgggaga cagagtgacc 60 atcacctgta gagccagcca gggcatctct tcttggctgg cctggtatca gcagaagcct 120 ggcaaggccc ctaagctgct gatctatgcc gcttccagtc tgcagagcgg cgtgccaagc 180 agattttctg gcagcggctc tggcaccgac ttcaccctga ccatatctag cctgcagcca 240 gaggacttcg ccacctacta ctgccagcag tacatcttct accctctgac cttcggccag 300 ggcaccaagg tggaaatcaa gcgtacggtg gccgctccca gcgtgttcat cttccccccc 360 agcgacgagc agctgaagag tggcaccgcc agcgtggtgt gcctgctgaa caacttctac 420 ccccgggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag 480 gagagcgtca ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc 540 ctgagcaagg ccgactacga gaagcataag gtgtacgcct gcgaggtgac ccaccagggc 600 ctgtccagcc ccgtgaccaa gagcttcaac aggggcgagt gc 642 <210> 252 <211> 12 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 252 Val Ala Ser Pro Ser Ala Pro Gly Gly Phe Asp Tyr 1 5 10 <210> 253 <211> 14 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 253 Ala Arg Val Ala Ser Pro Ser Ala Pro Gly Gly Phe Asp Tyr 1 5 10 <210> 254 <211> 123 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 254 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Arg Ile Lys Ser Lys Thr Asp Ala Gly Thr Thr Asp Tyr Ala Ala 50 55 60 Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Ala Arg Val Ala Ser Pro Ser Ala Pro Gly Gly Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 255 <211> 369 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 255 gaagtgcagc tggtggaatc tggcggcgga cttgtgaaac ctggcggctc tctgagactg 60 agctgtgccg cttccggctt caccttcagc aatgcctgga tgagctgggt ccgacaggcc 120 cctggaaaag gccttgagtg ggtcggacgg atcaagagca agaccgatgc cggcaccacc 180 gattatgctg cccctgtgaa gggcagattc accatcagca gggacgacag caagaacacc 240 ctgtacctgc agatgaacag cctgaaaacc gaggacaccg ccgtgtacta ctgcgccaga 300 gtggcttctc cttctgctcc cggcggattc gattattggg gccagggaac actggtcacc 360 gtgtctagt 369 <210> 256 <211> 453 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 256 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Arg Ile Lys Ser Lys Thr Asp Ala Gly Thr Thr Asp Tyr Ala Ala 50 55 60 Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Ala Arg Val Ala Ser Pro Ser Ala Pro Gly Gly Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 115 120 125 Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 130 135 140 Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Cys Pro Val 145 150 155 160 Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 165 170 175 Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 180 185 190 Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 195 200 205 Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys 210 215 220 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 225 230 235 240 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 245 250 255 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 260 265 270 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 275 280 285 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 290 295 300 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 305 310 315 320 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 325 330 335 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 340 345 350 Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 355 360 365 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Cys Asp Ile Ala 370 375 380 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 385 390 395 400 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 405 410 415 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 420 425 430 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 435 440 445 Leu Ser Pro Gly Lys 450 <210> 257 <211> 1359 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 257 gaagtgcagc tggtggaatc tggcggcgga cttgtgaaac ctggcggctc tctgagactg 60 agctgtgccg cttccggctt caccttcagc aatgcctgga tgagctgggt ccgacaggcc 120 cctggaaaag gccttgagtg ggtcggacgg atcaagagca agaccgatgc cggcaccacc 180 gattatgctg cccctgtgaa gggcagattc accatcagca gggacgacag caagaacacc 240 ctgtacctgc agatgaacag cctgaaaacc gaggacaccg ccgtgtacta ctgcgccaga 300 gtggcttctc cttctgctcc cggcggattc gattattggg gccagggaac actggtcacc 360 gtgtctagtg ctagcaccaa gggcccaagt gtgtttcccc tggcccccag cagcaagtct 420 acttccggcg gaactgctgc cctgggttgc ctggtgaagg actacttccc ctgtcccgtg 480 acagtgtcct ggaactctgg ggctctgact tccggcgtgc acaccttccc cgccgtgctg 540 cagagcagcg gcctgtacag cctgagcagc gtggtgacag tgccctccag ctctctggga 600 acccagacct atatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagaga 660 gtggagccca agagctgcga caagacccac acctgccccc cctgcccagc tccagaactg 720 ctgggagggc cttccgtgtt cctgttcccc cccaagccca aggacaccct gatgatcagc 780 aggacccccg aggtgacctg cgtggtggtg gacgtgtccc acgaggaccc agaggtgaag 840 ttcaactggt acgtggacgg cgtggaggtg cacaacgcca agaccaagcc cagagaggag 900 cagtacaaca gcacctacag ggtggtgtcc gtgctgaccg tgctgcacca ggactggctg 960 aacggcaaag aatacaagtg caaagtctcc aacaaggccc tgccagcccc aatcgaaaag 1020 acaatcagca aggccaaggg ccagccacgg gagccccagg tgtacaccct gccccccagc 1080 cgggaggaga tgaccaagaa ccaggtgtcc ctgacctgtc tggtgaaggg cttctacccc 1140 tgtgatatcg ccgtggagtg ggagagcaac ggccagcccg agaacaacta caagaccacc 1200 cccccagtgc tggacagcga cggcagcttc ttcctgtaca gcaagctgac cgtggacaag 1260 tccaggtggc agcagggcaa cgtgttcagc tgcagcgtga tgcacgaggc cctgcacaac 1320 cactacaccc agaagtccct gagcctgagc cccggcaag 1359 <210> 258 <211> 9 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 258 Gln Gln Ser Leu Phe Ala Pro Phe Thr 1 5 <210> 259 <211> 6 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 259 Ser Leu Phe Ala Pro Phe 1 5 <210> 260 <211> 107 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 260 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Leu Phe Ala Pro Phe 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 261 <211> 321 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 261 gacatccaga tgacacagag ccctagcagc ctgtctgcca gcgtgggaga cagagtgacc 60 atcacctgta gagccagcca gggcatcagc aactacctgg cctggtatca gcagaaaccc 120 ggcaaggtgc ccaagctgct gatctacgct gccagcacac tgcagagcgg agtgcctagc 180 agattttctg gcagcggctc cggcaccgat ttcaccctga ccatatctag cctgcagcca 240 gaggacgtgg ccacctacta ctgtcagcag agcctgttcg cccctttcac ctttggccag 300 ggcaccaagg tggaaatcaa g 321 <210> 262 <211> 214 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polipéptido Sintético <400> 262 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Leu Phe Ala Pro Phe 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 100 105 110 Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 115 120 125 Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 130 135 140 Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 145 150 155 160 Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 165 170 175 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 180 185 190 Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 195 200 205 Phe Asn Arg Gly Glu Cys 210 <210> 263 <211> 642 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Polinucleótido Sintético " <400> 263 gacatccaga tgacacagag ccctagcagc ctgtctgcca gcgtgggaga cagagtgacc 60 atcacctgta gagccagcca gggcatcagc aactacctgg cctggtatca gcagaaaccc 120 ggcaaggtgc ccaagctgct gatctacgct gccagcacac tgcagagcgg agtgcctagc 180 agattttctg gcagcggctc cggcaccgat ttcaccctga ccatatctag cctgcagcca 240 gaggacgtgg ccacctacta ctgtcagcag agcctgttcg cccctttcac ctttggccag 300 ggcaccaagg tggaaatcaa gcgtacggtg gccgctccca gcgtgttcat cttccccccc 360 agcgacgagc agctgaagag tggcaccgcc agcgtggtgt gcctgctgaa caacttctac 420 ccccgggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag 480 gagagcgtca ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc 540 ctgagcaagg ccgactacga gaagcataag gtgtacgcct gcgaggtgac ccaccagggc 600 ctgtccagcc ccgtgaccaa gagcttcaac aggggcgagt gc 642 <210> 264 <211> 21 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Oligonucleótido Sintético" <400> 264 ctctagcgcc accatgaaac a 21 <210> 265 <211> 18 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Oligonucleótido Sintético" <400> 265 agcccagcaa caccaagg 18 <210> 266 <211> 20 <212> ADN <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Oligonucleótido Sintético" <400> 266 taatacgact cactataggg 20 <210> 267 <211> 6 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético 6xHis tag" <400> 267 His His His His His His 1 5 <210> 268 <211> 359 <212> PRT <213> Homo sapiens <400> 268 Met Thr Leu Glu Ser Ile Met Ala Cys Cys Leu Ser Glu Glu Ala Lys 1 5 10 15 Glu Ala Arg Arg Ile Asn Asp Glu Ile Glu Arg Gln Leu Arg Arg Asp 20 25 30 Lys Arg Asp Ala Arg Arg Glu Leu Lys Leu Leu Leu Leu Gly Thr Gly 35 40 45 Glu Ser Gly Lys Ser Thr Phe Ile Lys Gln Met Arg Ile Ile His Gly 50 55 60 Ser Gly Tyr Ser Asp Glu Asp Lys Arg Gly Phe Thr Lys Leu Val Tyr 65 70 75 80 Gln Asn Ile Phe Thr Ala Met Gln Ala Met Ile Arg Ala Met Asp Thr 85 90 95 Leu Lys Ile Pro Tyr Lys Tyr Glu His Asn Lys Ala His Ala Gln Leu 100 105 110 Val Arg Glu Val Asp Val Glu Lys Val Ser Ala Phe Glu Asn Pro Tyr 115 120 125 Val Asp Ala Ile Lys Ser Leu Trp Asn Asp Pro Gly Ile Gln Glu Cys 130 135 140 Tyr Asp Arg Arg Arg Glu Tyr Gln Leu Ser Asp Ser Thr Lys Tyr Tyr 145 150 155 160 Leu Asn Asp Leu Asp Arg Val Ala Asp Pro Ala Tyr Leu Pro Thr Gln 165 170 175 Gln Asp Val Leu Arg Val Arg Val Pro Thr Thr Gly Ile Ile Glu Tyr 180 185 190 Pro Phe Asp Leu Gln Ser Val Ile Phe Arg Met Val Asp Val Gly Gly 195 200 205 Gln Arg Ser Glu Arg Arg Lys Trp Ile His Cys Phe Glu Asn Val Thr 210 215 220 Ser Ile Met Phe Leu Val Ala Leu Ser Glu Tyr Asp Gln Val Leu Val 225 230 235 240 Glu Ser Asp Asn Glu Asn Arg Met Glu Glu Ser Lys Ala Leu Phe Arg 245 250 255 Thr Ile Ile Thr Tyr Pro Trp Phe Gln Asn Ser Ser Val Ile Leu Phe 260 265 270 Leu Asn Lys Lys Asp Leu Leu Glu Glu Lys Ile Met Tyr Ser His Leu 275 280 285 Val Asp Tyr Phe Pro Glu Tyr Asp Gly Pro Gln Arg Asp Ala Gln Ala 290 295 300 Ala Arg Glu Phe Ile Leu Lys Met Phe Val Asp Leu Asn Pro Asp Ser 305 310 315 320 Asp Lys Ile Ile Tyr Ser His Phe Thr Cys Ala Thr Asp Thr Glu Asn 325 330 335 Ile Arg Phe Val Phe Ala Ala Val Lys Asp Thr Ile Leu Gln Leu Asn 340 345 350 Leu Lys Glu Tyr Asn Leu Val 355 <210> 269 <211> 6343 <212> ADN <213> Homo sapiens <400> 269 agactatccg ctcccaccgc gcccccggcc cacctggtgg ccccggccct ggccgccgcc 60 cccgcggcgg ttcccggagc tcgtcccgga cgcgcgcccg ggcggcgggg gctcggcggc 120 caccgctgcc tcgggggagc gagggcggga gggtgtgtgt gcgcgctgtg agcagggggt 180 gccggcgggg ctgcagcgga ggcactttgg aagaatgact ctggagtcca tcatggcgtg 240 ctgcctgagc gaggaggcca aggaagcccg gcggatcaac gacgagatcg agcggcagct 300 ccgcagggac aagcgggacg cccgccggga gctcaagctg ctgctgctcg ggacaggaga 360 gagtggcaag agtacgttta tcaagcagat gagaatcatc catgggtcag gatactctga 420 tgaagataaa aggggcttca ccaagctggt gtatcagaac atcttcacgg ccatgcaggc 480 catgatcaga gccatggaca cactcaagat cccatacaag tatgagcaca ataaggctca 540 tgcacaatta gttcgagaag ttgatgtgga gaaggtgtct gcttttgaga atccatatgt 600 agatgcaata aagagtttat ggaatgatcc tggaatccag gaatgctatg atagacgacg 660 agaatatcaa ttatctgact ctaccaaata ctatcttaat gacttggacc gcgtagctga 720 ccctgcctac ctgcctacgc aacaagatgt gcttagagtt cgagtcccca ccacagggat 780 catcgaatac ccctttgact tacaaagtgt cattttcaga atggtcgatg tagggggcca 840 aaggtcagag agaagaaaat ggatacactg ctttgaaaat gtcacctcta tcatgtttct 900 agtagcgctt agtgaatatg atcaagttct cgtggagtca gacaatgaga accgaatgga 960 ggaaagcaag gctctcttta gaacaattat cacatacccc tggttccaga actcctcggt 1020 tattctgttc ttaaacaaga aagatcttct agaggagaaa atcatgtatt cccatctagt 1080 cgactacttc ccagaatatg atggacccca gagagatgcc caggcagccc gagaattcat 1140 tctgaagatg ttcgtggacc tgaacccaga cagtgacaaa attatctact cccacttcac 1200 gtgcgccaca gacaccgaga atatccgctt tgtctttgct gccgtcaagg acaccatcct 1260 ccagttgaac ctgaaggagt acaatctggt ctaattgtgc ctcctagaca cccgccctgc 1320 ccttccctgg tgggctattg aagatacaca agagggactg tatttctgtg gaaaacaatt 1380 tgcataatac taatttattg ccgtcctgga ctctgtgtga gcgtgtccac agagtttgta 1440 gtaaatatta tgattttatt taaactattc agaggaaaaa cagaggatgc tgaagtacag 1500 tcccagcaca tttcctctct atcttttttt taggcaaaac cttgtgactc agtgtatttt 1560 aaattctcag tcatgcactc acaaagataa gacttgtttc tttctgtctc tctctctttt 1620 tcttttctat ggagcaaaac aaagctgatt tccctttttt cttcccccgc taattcatac 1680 ctccctcctg atgtttttcc caggttacaa tggcctttat cctagttcca ttcttggtca 1740 agtttttctc tcaaatgata cagtcaggac acatcgttcg atttaagcca tcatcagctt 1800 aatttaagtt tgtagttttt gctgaaggat tatatgtatt aatacttacg gttttaaatg 1860 tgttgctttg gatacacaca tagtttcttt tttaatagaa tatactgtct tgtctcactt 1920 tggactggga cagtggatgc ccatctaaaa gttaagtgtc atttctttta gatgtttacc 1980 ttcagccata gcttgattgc tcagagaaat atgcagaagg caggatcaaa gacacacagg 2040 agtcctttct tttgaaatgc cacgtgccat tgtctttcct cccttctttg cttctttttc 2100 ttaccctctc tttcaattgc agatgccaaa aaagatgcca acagacacta cattacccta 2160 atggctgcta cccagaacct ttttataggt tgttcttaat ttttttgttg ttgttgttca 2220 agcttttcct ttcttttttt tcttggtgtt tgggccacga ttttaaaatg acttttatta 2280 tgggtatgtg ttgccaaagc tggctttttg tcaaataaaa tgaatacgaa cttaaaaaat 2340 aaaagctggt atcttaaaat gtaagagagt aagactgtga agcctaaaat gactggctga 2400 gaatgaacca gaaatgccat ttgccaaaca gttgtaacta gaaatttgat tctcacggtc 2460 cattcttttc tttgtcctta agatgacatt gttagtgttc acgtcccatg ttcagtgtcc 2520 aaaccggcaa tgtaaaaagt atcctgtgtg gtttaacagg aaatctgttt atgtctcttt 2580 atttgaaacc agttttactc tcagtggttc tttaagttca atgaagtctg ccaggaacat 2640 tggttggtag tattattccg acacctttaa tttccaaaat ctgaagttcc tgctagttta 2700 ccaccttcat gatcttcttg aactggtaac tgattaggtt gaacttatgg aagatttgtg 2760 gacttaactc aaaagtaacc tctcagtgtt ctatagaaca tgtatttgtg taactgaacc 2820 taccaggaga aatgtttgga attctatatg tgcaattttt caacaaatgc aaaaaaaata 2880 cagcacatgt attgacaagc ttctgtcaag cagcttgagt tgaaatttga tttaagaaaa 2940 taaatcatga ttgttcaaag ctgctgggac gttagaatta ggccatgata ctggtctcat 3000 tttaactaca gtggtatttg gcactagtgt aaacttccat ataaatcact cttttggaac 3060 aacaaagggg gagggagaaa aatcacggcc tgttaaatga gtaccaaagc cgcccaacag 3120 taatgagatg ttctcatcct tgattctccc agcctcaaac aacacagctt actttttttt 3180 tcccttgctc agaaagtacc tgtaatttaa caaacagact gcctgtaggt atagtgcaat 3240 tacaaatgct ctaatcattg tacatacatc tctcttgata ttgcagcatc catactggct 3300 ttgtaatcat taattttttg gcagattgaa tgtgctgtat tgatatgtat ctatgtaatt 3360 gtattgtatg tctatagcta attcacgttt tgaataatgt tattttattt acttttttaa 3420 gagaggagaa tgtaaatttg tcagtttatt tctgactagg gatattttct ttccatttag 3480 aaaagaagaa aaaaaaaaaa ccttactgtc atacagagcg gtactagcgt cgtgctgtat 3540 aaaatcattt gcacattcct gagtagaggt atactgatta taagacccaa aggtaatttc 3600 atagcaaaat acataaaatc agtcggagct tttatacaaa catggaaacc aactttgtag 3660 aacttttgcc atttgatcta ggattggaat atgagctttt atacaattca tattcttatt 3720 tggcaaatgc acagtttagt attacctctc tgatggcctt tactagaaag gcagttttag 3780 aagctattgt gatccactaa ggaaatgttt taacagctag agaccactgc ttgcctgaaa 3840 gggcgttctt aaatttggtg cagcaaaaaa aaaaaaaaaa aaaaaaaaaa ttaaacaaca 3900 acatttgaag gcctacagtg tgtatagaga aaacctcatc acaagatcat aagtgttaca 3960 gttttaggga atcaagatat tctatttaat agagctatag taaatgtagt caattaaacc 4020 tgatctcaaa gcttgaagaa gctgagcaaa acagggaaag attgttatat ttgtctttat 4080 gaaattggga tggaatttgc tatgcagaat tgaggtttgt ggcttcgctg ttcctgtagg 4140 gtgcatgaca agatcccttc tcttgagaaa ggaaaaaatt gatcacccta gcagcagtga 4200 tgcatagaaa cctaatttta gccacaccag tcaatcgaag ctaaaggatt ttcttttttg 4260 tttcttcggg gttttattga aggggctagg ggcgggacgg gattcttttc agttttgtat 4320 aaaaacaaag tttactcatg ctttatatta tattgtgatt gcaagcgtta taagcgtgtg 4380 ccactggcct cctattgttg atgcttaggt aatggaggcc tgtggtgagt tttatggtga 4440 cttgggcatg tcttattcaa aaacaaaaac ataaaacaca gaaacctttc ttcagcatac 4500 caaggcaagc agccatttca tgactcactt aacacattgc agtgtaccag tttacagatg 4560 atttttccct ttttgcgtga catggcagtt ctaaccccca gagaattcct tatttgtaaa 4620 ttggaagttt ctactatgcc ttacagagct taaattcaga agtttgtgcc tcatatctga 4680 aacaaaggga aataacacac ccattcaaaa gtaaataaat ctcctagaag tttttgtttt 4740 taacatttcc atataaagag ctctgttgaa tgtcatgaat agactggaaa aaaaaatttt 4800 aagaacctgc atatgttgtt tactagcaga tgacaactac aaaaggaatc tgaagaacac 4860 gtaaaacttg tatttttttt tttttggtag attaactagc aggcctattt taaaaaggta 4920 attcagctaa agggcaattt acttttttgt acttcagact atcttgattg tcaaagtgta 4980 cgaactgtaa ttttaaaatt tatactgcca catgattgta aattttagtt gtcttaagtt 5040 aggaattggt gaaaagctat ttatgctgga tttgggtcaa aatgacttat ttgcaaaaaa 5100 ataaataatg ggaagaaagg gctgtataat gaaatactgc aagactcaca tattggttgg 5160 aaatttccct caaatcacct accgattacc cttgatttcc ctttgttttc agtttctcaa 5220 aacgaatgaa atgaaatata gcagaatgtt aacccatata aaaataaagt gtacccaaat 5280 attgtaatgt atattgctgc tcttcttcaa attaaataag ggtttaaaac cacttaattg 5340 gtaatcaaca tctcaattga tacaaataag gtgtgcttgg tatacattaa tattttcttc 5400 caaagatata tctttggtta gaaacacaaa aaaataaaac tagtaatatt gtatgtttat 5460 ctatctctac atatttccag catatgtagc gttaatagat ctgtcctggt aactgtgtct 5520 ttgggatttc attttggttc catcaaatta ggaaaagaaa tggcttagtt gtatatgatt 5580 agctagagat ttttggagcc agacacctgc tgtttagtag ataacttagt acagacccta 5640 aacttgtcat ttgtttttct cacagaatag ccatttcctg ctgtcttccc aatgatcact 5700 gccctttcaa taacactctt gcctctagaa tcatatgttc aaagtatgaa tacacaccta 5760 gcacatagta ggtgctcaaa tattaatttc ctccttgcct tccttatcta ccctgtgtcc 5820 tccatttccc cgtatgattc caacccaata tagcaaatga catttacatg ttatgaaaac 5880 atctattggg taaaatcaga tcttggataa agaaattctg acttttatat aagcttttgg 5940 tagacagaaa aaacagaaag gtattcgttg gtagaacatt tttaagttca ggaaagaaag 6000 ctggaataat actacgtaac tttgtccagg ttactttgac tgaaacacgt ttttggtgga 6060 tttcttttcc tcaaagaact ctctaaatgc aactccttgc tggattcctc acccatcatc 6120 ctgttggaaa cccttactag acctatgtat ttagggagtt ttgtcagaaa acatttttaa 6180 cttgcagtat ttaaaagaat atttactgtt cctaaaatgt cattcaaatg catgtactgt 6240 ctattgtttg gggatgggaa ctagttttgc aaaaaacacc taatgttgta taataatgcc 6300 ccaatgatct tgctggttaa aaatacagta tttttggcca taa 6343 <210> 270 <211> 359 <212> PRT <213> Homo sapiens <400> 270 Met Thr Leu Glu Ser Met Met Ala Cys Cys Leu Ser Asp Glu Val Lys 1 5 10 15 Glu Ser Lys Arg Ile Asn Ala Glu Ile Glu Lys Gln Leu Arg Arg Asp 20 25 30 Lys Arg Asp Ala Arg Arg Glu Leu Lys Leu Leu Leu Leu Gly Thr Gly 35 40 45 Glu Ser Gly Lys Ser Thr Phe Ile Lys Gln Met Arg Ile Ile His Gly 50 55 60 Ala Gly Tyr Ser Glu Glu Asp Lys Arg Gly Phe Thr Lys Leu Val Tyr 65 70 75 80 Gln Asn Ile Phe Thr Ala Met Gln Ala Met Ile Arg Ala Met Glu Thr 85 90 95 Leu Lys Ile Leu Tyr Lys Tyr Glu Gln Asn Lys Ala Asn Ala Leu Leu 100 105 110 Ile Arg Glu Val Asp Val Glu Lys Val Thr Thr Phe Glu His Gln Tyr 115 120 125 Val Ser Ala Ile Lys Thr Leu Trp Glu Asp Pro Gly Ile Gln Glu Cys 130 135 140 Tyr Asp Arg Arg Arg Glu Tyr Gln Leu Ser Asp Ser Ala Lys Tyr Tyr 145 150 155 160 Leu Thr Asp Val Asp Arg Ile Ala Thr Leu Gly Tyr Leu Pro Thr Gln 165 170 175 Gln Asp Val Leu Arg Val Arg Val Pro Thr Thr Gly Ile Ile Glu Tyr 180 185 190 Pro Phe Asp Leu Glu Asn Ile Ile Phe Arg Met Val Asp Val Gly Gly 195 200 205 Gln Arg Ser Glu Arg Arg Lys Trp Ile His Cys Phe Glu Asn Val Thr 210 215 220 Ser Ile Met Phe Leu Val Ala Leu Ser Glu Tyr Asp Gln Val Leu Val 225 230 235 240 Glu Ser Asp Asn Glu Asn Arg Met Glu Glu Ser Lys Ala Leu Phe Arg 245 250 255 Thr Ile Ile Thr Tyr Pro Trp Phe Gln Asn Ser Ser Val Ile Leu Phe 260 265 270 Leu Asn Lys Lys Asp Leu Leu Glu Asp Lys Ile Leu Tyr Ser His Leu 275 280 285 Val Asp Tyr Phe Pro Glu Phe Asp Gly Pro Gln Arg Asp Ala Gln Ala 290 295 300 Ala Arg Glu Phe Ile Leu Lys Met Phe Val Asp Leu Asn Pro Asp Ser 305 310 315 320 Asp Lys Ile Ile Tyr Ser His Phe Thr Cys Ala Thr Asp Thr Glu Asn 325 330 335 Ile Arg Phe Val Phe Ala Ala Val Lys Asp Thr Ile Leu Gln Leu Asn 340 345 350 Leu Lys Glu Tyr Asn Leu Val 355 <210> 271 <211> 4190 <212> ADN <213> Homo sapiens <400> 271 aggttgtccg gcgctgtcgc tcggttgcgg cggctgcggt tggcggtggc tgcggcggcg 60 gcgcgggctg agtgcggccg cgcgggagtc cgcggctggc gcggcccgag cggggacccg 120 gcggctcgcc aggcggcggc cgaggcgggg cgggccggcc cggggccgag ggccggtggc 180 cgaggccgga gggccgcggc gggcggcggc cgaggcggct ccggccaggg ccgggccggg 240 ggccgggggg cggcggcggg caggcggccg cgtcggccgg ggccgggacg atgactctgg 300 agtccatgat ggcgtgttgc ctgagcgatg aggtgaagga gtccaagcgg atcaacgccg 360 agatcgagaa gcagctgcgg cgggacaagc gcgacgcccg gcgcgagctc aagctgctgc 420 tgctcggcac gggcgagagc gggaagagca cgttcatcaa gcagatgcgc atcatccacg 480 gcgccggcta ctcggaggag gacaagcgcg gcttcaccaa gctcgtctac cagaacatct 540 tcaccgccat gcaggccatg atccgggcca tggagacgct caagatcctc tacaagtacg 600 agcagaacaa ggccaatgcg ctcctgatcc gggaggtgga cgtggagaag gtgaccacct 660 tcgagcatca gtacgtcagt gccatcaaga ccctgtggga ggacccgggc atccaggaat 720 gctacgaccg caggcgcgag taccagctct ccgactctgc caagtactac ctgaccgacg 780 ttgaccgcat cgccaccttg ggctacctgc ccacccagca ggacgtgctg cgggtccgcg 840 tgcccaccac cggcatcatc gagtaccctt tcgacctgga gaacatcatc ttccggatgg 900 tggatgtggg gggccagcgg tcggagcgga ggaagtggat ccactgcttt gagaacgtga 960 catccatcat gtttctcgtc gccctcagcg aatacgacca agtcctggtg gagtcggaca 1020 acgagaaccg gatggaggag agcaaagccc tgttccggac catcatcacc tacccctggt 1080 tccagaactc ctccgtcatc ctcttcctca acaagaagga cctgctggag gacaagatcc 1140 tgtactcgca cctggtggac tacttccccg agttcgatgg tccccagcgg gacgcccagg 1200 cggcgcggga gttcatcctg aagatgttcg tggacctgaa ccccgacagc gacaagatca 1260 tctactcaca cttcacgtgt gccaccgaca cggagaacat ccgcttcgtg ttcgcggccg 1320 tgaaggacac catcctgcag ctcaacctca aggagtacaa cctggtctga gcgcccaggc 1380 ccagggagac gggatggaga cacggggcag gaccttcctt ccacggagcc tgcggctgcc 1440 gggcgggtgg cgctgccgag tccgggccgg ggcctctgcc cgcgggagga gatttttttt 1500 tttcatattt ttaacaaatg gtttttattt cacagttatc aggggatgta catctctccc 1560 tccgtacact tcgcgcacct tctcaccttt tgtcaacggc aaaggcagcc tttttctggc 1620 cttgacttat ggctcgcttt tttctaaaaa aaaaaaaaaa agaaagaaag aaaaaaagca 1680 acgaaacata aaacacacaa gcgccccgtg cccccagtga ctctgggcct cacagagccc 1740 ccgccagcca gcatggggcc ccgccctgca gccagtcacg cgcccccaca ccgcagcccc 1800 ccgtggctgt ccttccaacc ccacgtgctt tttctttctc ctgcccgctt cttttcttca 1860 tcacaaaagg cgtggagact cggagacgga cgtttttccc cttttttaag ttattgacgc 1920 ccagcgcgcc tcgcctcttc acccatcaac gctgtgcttt gcccactgga ctcctgaaga 1980 gggggtgggg ggctccctcg gtcgcccacc ctgggaagtg cctaaccttt tattttattt 2040 tatttttttg aggaaaaaga acgcctgact cacaggttga agaaacaccc tgggccctct 2100 ctcatggccg ggttccccgt ccctctgcag aggctgggaa gggtccccgg gctggagcca 2160 cgggggcttc tctgggctgt gcctccgggg ccaacactgg ctgcttgggg ctgcccgggg 2220 actccagagg gctgcacggc caccctgccc tggctagagc gcaccccacc ggagcccacg 2280 tgggctgggc ggctggaggg atggtccccc ggtgacactg ggagaaaggc cacttggatg 2340 ggggcgtttc tgttttgttc cgctttgtga tgtcaccaat ttggaaacag cgagggtggg 2400 tggggacttt tacagaatat tctcaggtgt gtacccgaga ggcagagaga gggacgtggc 2460 cggcagctct gtgcgtggcc ttgtcccaag cacttgcgcc cgcccccgag cgccgccccc 2520 ggggagcggg aagccagcac tcgcactttg gccaggggcg cgtggaaggt ggtggcaggc 2580 accggcctgg gcagcttcca ggcctggctg gccacgacca cggcccgagg gggagcccgc 2640 caggccacgc cgcactgagc cacagccccg ggggccgcct cccggggccc cttgaggcac 2700 tgaggcaccg agactggttc tccccgagag actcggaagg tggggaacga ggggactgtg 2760 tttggggagg tggctttttc gtctgctgtt gactgaacac tacagcgccc tgtggttccg 2820 ggcttcgcac agctgtccca gggatggatc gcctgtgctg ccttcgcccg ccgccacacc 2880 gggaccctgc acggctgctt ctggcctcga cagatgacaa aagaaacagc cccaaaatac 2940 gaccactcca accagcagtt cccgcctgcc tgcccgccac tgtcaggcct gccctggcct 3000 cctcgtccgc agggctgtct gctggcttct gggggcagaa gagcggggag ccccgtggaa 3060 gggtcagggg agaccaggtc agggcagcta catttctggt gatcagcccc atggggagac 3120 ggggctggcg ggataccccc cccccggctt ccccacacca cttctgtctc acccggaagc 3180 gtcctttttt tgtgccaggt gtctacctaa gagggttggt gccagaagcc ccccatggcg 3240 agtgctgggg cccggcggtg ccctggggga gcagatgggg ccacccctgg cagggccgct 3300 acaacctttt ccagcagcgg agccctctgg ggggcctgtg cttgtggcat ctctgagggc 3360 ctagattgca caaggtgacc tggccgtggc ctgagggtgg agtcgcccag cacgcaggcc 3420 ggggcgctgc ggggctaagt attaggcctt cccagggagg gggcgtgcca agcatcccag 3480 agccgggctg ggaccgccaa aacgtcgtgg cctggatcct ctgggtctga gtgcctgatc 3540 ccctgccccc caaaaaagca gaggtaggtg ttgcaggccc agggcagggg tgcctgcccc 3600 aggagagtcc caggcagtgg ttctcgtgcc agtggcaccc aggggcaagg acagccaacc 3660 cccacccttg ccacgtgtgg ggccacgtgg gcatgtgggg tgtgtgtttt taccttggtg 3720 aatctcacct gccaacgatt tctcgtgagt gccgaccacc ttctccgacc atgttacgcc 3780 cgggcggcag cagcccccgg ccactgcaaa cccatgccct gggtcccccg gctcccccag 3840 ggaggcatcc ccgtgccaat gtcccccagt ggtggcagca gatcctgtgg ccggcctggc 3900 ggacgggacc cagtgatact tgtatattac acagtcctga tttcagacaa tttcaacctt 3960 aatctattta aaaaagaata ttctatacaa gctgttttta agccttttac catttgaaat 4020 gcatgtgttg tgcgcgttgg ggatgggagg aggggctgag gagcggctca gtgtcacctc 4080 ccacagccac cggccctgac ccttaatcca gacaccgatg gaagtcgact tttcatatct 4140 ttctcctgaa atgaactctg ttttaaattg gaataaattt tgttcctaaa 4190 <210> 272 <211> 661 <212> PRT <213> Homo sapiens <400> 272 Met Asp Leu Val Leu Lys Arg Cys Leu Leu His Leu Ala Val Ile Gly 1 5 10 15 Ala Leu Leu Ala Val Gly Ala Thr Lys Val Pro Arg Asn Gln Asp Trp 20 25 30 Leu Gly Val Ser Arg Gln Leu Arg Thr Lys Ala Trp Asn Arg Gln Leu 35 40 45 Tyr Pro Glu Trp Thr Glu Ala Gln Arg Leu Asp Cys Trp Arg Gly Gly 50 55 60 Gln Val Ser Leu Lys Val Ser Asn Asp Gly Pro Thr Leu Ile Gly Ala 65 70 75 80 Asn Ala Ser Phe Ser Ile Ala Leu Asn Phe Pro Gly Ser Gln Lys Val 85 90 95 Leu Pro Asp Gly Gln Val Ile Trp Val Asn Asn Thr Ile Ile Asn Gly 100 105 110 Ser Gln Val Trp Gly Gly Gln Pro Val Tyr Pro Gln Glu Thr Asp Asp 115 120 125 Ala Cys Ile Phe Pro Asp Gly Gly Pro Cys Pro Ser Gly Ser Trp Ser 130 135 140 Gln Lys Arg Ser Phe Val Tyr Val Trp Lys Thr Trp Gly Gln Tyr Trp 145 150 155 160 Gln Val Leu Gly Gly Pro Val Ser Gly Leu Ser Ile Gly Thr Gly Arg 165 170 175 Ala Met Leu Gly Thr His Thr Met Glu Val Thr Val Tyr His Arg Arg 180 185 190 Gly Ser Arg Ser Tyr Val Pro Leu Ala His Ser Ser Ser Ala Phe Thr 195 200 205 Ile Thr Asp Gln Val Pro Phe Ser Val Ser Val Ser Gln Leu Arg Ala 210 215 220 Leu Asp Gly Gly Asn Lys His Phe Leu Arg Asn Gln Pro Leu Thr Phe 225 230 235 240 Ala Leu Gln Leu His Asp Pro Ser Gly Tyr Leu Ala Glu Ala Asp Leu 245 250 255 Ser Tyr Thr Trp Asp Phe Gly Asp Ser Ser Gly Thr Leu Ile Ser Arg 260 265 270 Ala Leu Val Val Thr His Thr Tyr Leu Glu Pro Gly Pro Val Thr Ala 275 280 285 Gln Val Val Leu Gln Ala Ala Ile Pro Leu Thr Ser Cys Gly Ser Ser 290 295 300 Pro Val Pro Gly Thr Thr Asp Gly His Arg Pro Thr Ala Glu Ala Pro 305 310 315 320 Asn Thr Thr Ala Gly Gln Val Pro Thr Thr Glu Val Val Gly Thr Thr 325 330 335 Pro Gly Gln Ala Pro Thr Ala Glu Pro Ser Gly Thr Thr Ser Val Gln 340 345 350 Val Pro Thr Thr Glu Val Ile Ser Thr Ala Pro Val Gln Met Pro Thr 355 360 365 Ala Glu Ser Thr Gly Met Thr Pro Glu Lys Val Pro Val Ser Glu Val 370 375 380 Met Gly Thr Thr Leu Ala Glu Met Ser Thr Pro Glu Ala Thr Gly Met 385 390 395 400 Thr Pro Ala Glu Val Ser Ile Val Val Leu Ser Gly Thr Thr Ala Ala 405 410 415 Gln Val Thr Thr Thr Glu Trp Val Glu Thr Thr Ala Arg Glu Leu Pro 420 425 430 Ile Pro Glu Pro Glu Gly Pro Asp Ala Ser Ser Ile Met Ser Thr Glu 435 440 445 Ser Ile Thr Gly Ser Leu Gly Pro Leu Leu Asp Gly Thr Ala Thr Leu 450 455 460 Arg Leu Val Lys Arg Gln Val Pro Leu Asp Cys Val Leu Tyr Arg Tyr 465 470 475 480 Gly Ser Phe Ser Val Thr Leu Asp Ile Val Gln Gly Ile Glu Ser Ala 485 490 495 Glu Ile Leu Gln Ala Val Pro Ser Gly Glu Gly Asp Ala Phe Glu Leu 500 505 510 Thr Val Ser Cys Gln Gly Gly Leu Pro Lys Glu Ala Cys Met Glu Ile 515 520 525 Ser Ser Pro Gly Cys Gln Pro Pro Ala Gln Arg Leu Cys Gln Pro Val 530 535 540 Leu Pro Ser Pro Ala Cys Gln Leu Val Leu His Gln Ile Leu Lys Gly 545 550 555 560 Gly Ser Gly Thr Tyr Cys Leu Asn Val Ser Leu Ala Asp Thr Asn Ser 565 570 575 Leu Ala Val Val Ser Thr Gln Leu Ile Met Pro Gly Gln Glu Ala Gly 580 585 590 Leu Gly Gln Val Pro Leu Ile Val Gly Ile Leu Leu Val Leu Met Ala 595 600 605 Val Val Leu Ala Ser Leu Ile Tyr Arg Arg Arg Leu Met Lys Gln Asp 610 615 620 Phe Ser Val Pro Gln Leu Pro His Ser Ser Ser His Trp Leu Arg Leu 625 630 635 640 Pro Arg Ile Phe Cys Ser Cys Pro Ile Gly Glu Asn Ser Pro Leu Leu 645 650 655 Ser Gly Gln Gln Val 660 <210> 273 <211> 626 <212> PRT <213> Homo sapiens <400> 273 Met Asp Leu Val Leu Lys Arg Cys Leu Leu His Leu Ala Val Ile Gly 1 5 10 15 Ala Leu Leu Ala Val Gly Ala Thr Lys Val Pro Arg Asn Gln Asp Trp 20 25 30 Leu Gly Val Ser Arg Gln Leu Arg Thr Lys Ala Trp Asn Arg Gln Leu 35 40 45 Tyr Pro Glu Trp Thr Glu Ala Gln Arg Leu Asp Cys Trp Arg Gly Gly 50 55 60 Gln Val Ser Leu Lys Val Ser Asn Asp Gly Pro Thr Leu Ile Gly Ala 65 70 75 80 Asn Ala Ser Phe Ser Ile Ala Leu Asn Phe Pro Gly Ser Gln Lys Val 85 90 95 Leu Pro Asp Gly Gln Val Ile Trp Val Asn Asn Thr Ile Ile Asn Gly 100 105 110 Ser Gln Val Trp Gly Gly Gln Pro Val Tyr Pro Gln Glu Thr Asp Asp 115 120 125 Ala Cys Ile Phe Pro Asp Gly Gly Pro Cys Pro Ser Gly Ser Trp Ser 130 135 140 Gln Lys Arg Ser Phe Val Tyr Val Trp Lys Thr Trp Gly Gln Tyr Trp 145 150 155 160 Gln Val Leu Gly Gly Pro Val Ser Gly Leu Ser Ile Gly Thr Gly Arg 165 170 175 Ala Met Leu Gly Thr His Thr Met Glu Val Thr Val Tyr His Arg Arg 180 185 190 Gly Ser Arg Ser Tyr Val Pro Leu Ala His Ser Ser Ser Ala Phe Thr 195 200 205 Ile Thr Asp Gln Val Pro Phe Ser Val Ser Val Ser Gln Leu Arg Ala 210 215 220 Leu Asp Gly Gly Asn Lys His Phe Leu Arg Asn Gln Pro Leu Thr Phe 225 230 235 240 Ala Leu Gln Leu His Asp Pro Ser Gly Tyr Leu Ala Glu Ala Asp Leu 245 250 255 Ser Tyr Thr Trp Asp Phe Gly Asp Ser Ser Gly Thr Leu Ile Ser Arg 260 265 270 Ala Leu Val Val Thr His Thr Tyr Leu Glu Pro Gly Pro Val Thr Ala 275 280 285 Gln Val Val Leu Gln Ala Ala Ile Pro Leu Thr Ser Cys Gly Ser Ser 290 295 300 Pro Val Pro Gly Thr Thr Asp Gly His Arg Pro Thr Ala Glu Ala Pro 305 310 315 320 Asn Thr Thr Ala Gly Gln Val Pro Thr Thr Glu Val Val Gly Thr Thr 325 330 335 Pro Gly Gln Ala Pro Thr Ala Glu Pro Ser Gly Thr Thr Ser Val Gln 340 345 350 Val Pro Thr Thr Glu Val Ile Ser Thr Ala Pro Val Gln Met Pro Thr 355 360 365 Ala Glu Ser Thr Ala Ala Gln Val Thr Thr Thr Glu Trp Val Glu Thr 370 375 380 Thr Ala Arg Glu Leu Pro Ile Pro Glu Pro Glu Gly Pro Asp Ala Ser 385 390 395 400 Ser Ile Met Ser Thr Glu Ser Ile Thr Gly Ser Leu Gly Pro Leu Leu 405 410 415 Asp Gly Thr Ala Thr Leu Arg Leu Val Lys Arg Gln Val Pro Leu Asp 420 425 430 Cys Val Leu Tyr Arg Tyr Gly Ser Phe Ser Val Thr Leu Asp Ile Val 435 440 445 Gln Gly Ile Glu Ser Ala Glu Ile Leu Gln Ala Val Pro Ser Gly Glu 450 455 460 Gly Asp Ala Phe Glu Leu Thr Val Ser Cys Gln Gly Gly Leu Pro Lys 465 470 475 480 Glu Ala Cys Met Glu Ile Ser Ser Pro Gly Cys Gln Pro Pro Ala Gln 485 490 495 Arg Leu Cys Gln Pro Val Leu Pro Ser Pro Ala Cys Gln Leu Val Leu 500 505 510 His Gln Ile Leu Lys Gly Gly Ser Gly Thr Tyr Cys Leu Asn Val Ser 515 520 525 Leu Ala Asp Thr Asn Ser Leu Ala Val Val Ser Thr Gln Leu Ile Met 530 535 540 Pro Val Pro Gly Ile Leu Leu Thr Gly Gln Glu Ala Gly Leu Gly Gln 545 550 555 560 Val Pro Leu Ile Val Gly Ile Leu Leu Val Leu Met Ala Val Val Leu 565 570 575 Ala Ser Leu Ile Tyr Arg Arg Arg Leu Met Lys Gln Asp Phe Ser Val 580 585 590 Pro Gln Leu Pro His Ser Ser Ser His Trp Leu Arg Leu Pro Arg Ile 595 600 605 Phe Cys Ser Cys Pro Ile Gly Glu Asn Ser Pro Leu Leu Ser Gly Gln 610 615 620 Gln Val 625 <210> 274 <211> 619 <212> PRT <213> Homo sapiens <400> 274 Met Asp Leu Val Leu Lys Arg Cys Leu Leu His Leu Ala Val Ile Gly 1 5 10 15 Ala Leu Leu Ala Val Gly Ala Thr Lys Val Pro Arg Asn Gln Asp Trp 20 25 30 Leu Gly Val Ser Arg Gln Leu Arg Thr Lys Ala Trp Asn Arg Gln Leu 35 40 45 Tyr Pro Glu Trp Thr Glu Ala Gln Arg Leu Asp Cys Trp Arg Gly Gly 50 55 60 Gln Val Ser Leu Lys Val Ser Asn Asp Gly Pro Thr Leu Ile Gly Ala 65 70 75 80 Asn Ala Ser Phe Ser Ile Ala Leu Asn Phe Pro Gly Ser Gln Lys Val 85 90 95 Leu Pro Asp Gly Gln Val Ile Trp Val Asn Asn Thr Ile Ile Asn Gly 100 105 110 Ser Gln Val Trp Gly Gly Gln Pro Val Tyr Pro Gln Glu Thr Asp Asp 115 120 125 Ala Cys Ile Phe Pro Asp Gly Gly Pro Cys Pro Ser Gly Ser Trp Ser 130 135 140 Gln Lys Arg Ser Phe Val Tyr Val Trp Lys Thr Trp Gly Gln Tyr Trp 145 150 155 160 Gln Val Leu Gly Gly Pro Val Ser Gly Leu Ser Ile Gly Thr Gly Arg 165 170 175 Ala Met Leu Gly Thr His Thr Met Glu Val Thr Val Tyr His Arg Arg 180 185 190 Gly Ser Arg Ser Tyr Val Pro Leu Ala His Ser Ser Ser Ala Phe Thr 195 200 205 Ile Thr Asp Gln Val Pro Phe Ser Val Ser Val Ser Gln Leu Arg Ala 210 215 220 Leu Asp Gly Gly Asn Lys His Phe Leu Arg Asn Gln Pro Leu Thr Phe 225 230 235 240 Ala Leu Gln Leu His Asp Pro Ser Gly Tyr Leu Ala Glu Ala Asp Leu 245 250 255 Ser Tyr Thr Trp Asp Phe Gly Asp Ser Ser Gly Thr Leu Ile Ser Arg 260 265 270 Ala Leu Val Val Thr His Thr Tyr Leu Glu Pro Gly Pro Val Thr Ala 275 280 285 Gln Val Val Leu Gln Ala Ala Ile Pro Leu Thr Ser Cys Gly Ser Ser 290 295 300 Pro Val Pro Gly Thr Thr Asp Gly His Arg Pro Thr Ala Glu Ala Pro 305 310 315 320 Asn Thr Thr Ala Gly Gln Val Pro Thr Thr Glu Val Val Gly Thr Thr 325 330 335 Pro Gly Gln Ala Pro Thr Ala Glu Pro Ser Gly Thr Thr Ser Val Gln 340 345 350 Val Pro Thr Thr Glu Val Ile Ser Thr Ala Pro Val Gln Met Pro Thr 355 360 365 Ala Glu Ser Thr Ala Ala Gln Val Thr Thr Thr Glu Trp Val Glu Thr 370 375 380 Thr Ala Arg Glu Leu Pro Ile Pro Glu Pro Glu Gly Pro Asp Ala Ser 385 390 395 400 Ser Ile Met Ser Thr Glu Ser Ile Thr Gly Ser Leu Gly Pro Leu Leu 405 410 415 Asp Gly Thr Ala Thr Leu Arg Leu Val Lys Arg Gln Val Pro Leu Asp 420 425 430 Cys Val Leu Tyr Arg Tyr Gly Ser Phe Ser Val Thr Leu Asp Ile Val 435 440 445 Gln Gly Ile Glu Ser Ala Glu Ile Leu Gln Ala Val Pro Ser Gly Glu 450 455 460 Gly Asp Ala Phe Glu Leu Thr Val Ser Cys Gln Gly Gly Leu Pro Lys 465 470 475 480 Glu Ala Cys Met Glu Ile Ser Ser Pro Gly Cys Gln Pro Pro Ala Gln 485 490 495 Arg Leu Cys Gln Pro Val Leu Pro Ser Pro Ala Cys Gln Leu Val Leu 500 505 510 His Gln Ile Leu Lys Gly Gly Ser Gly Thr Tyr Cys Leu Asn Val Ser 515 520 525 Leu Ala Asp Thr Asn Ser Leu Ala Val Val Ser Thr Gln Leu Ile Met 530 535 540 Pro Gly Gln Glu Ala Gly Leu Gly Gln Val Pro Leu Ile Val Gly Ile 545 550 555 560 Leu Leu Val Leu Met Ala Val Val Leu Ala Ser Leu Ile Tyr Arg Arg 565 570 575 Arg Leu Met Lys Gln Asp Phe Ser Val Pro Gln Leu Pro His Ser Ser 580 585 590 Ser His Trp Leu Arg Leu Pro Arg Ile Phe Cys Ser Cys Pro Ile Gly 595 600 605 Glu Asn Ser Pro Leu Leu Ser Gly Gln Gln Val 610 615 <210> 275 <211> 575 <212> PRT <213> Homo sapiens <400> 275 Met Asp Leu Val Leu Lys Arg Cys Leu Leu His Leu Ala Val Ile Gly 1 5 10 15 Ala Leu Leu Ala Val Gly Ala Thr Lys Gly Ser Gln Val Trp Gly Gly 20 25 30 Gln Pro Val Tyr Pro Gln Glu Thr Asp Asp Ala Cys Ile Phe Pro Asp 35 40 45 Gly Gly Pro Cys Pro Ser Gly Ser Trp Ser Gln Lys Arg Ser Phe Val 50 55 60 Tyr Val Trp Lys Thr Trp Gly Gln Tyr Trp Gln Val Leu Gly Gly Pro 65 70 75 80 Val Ser Gly Leu Ser Ile Gly Thr Gly Arg Ala Met Leu Gly Thr His 85 90 95 Thr Met Glu Val Thr Val Tyr His Arg Arg Gly Ser Arg Ser Tyr Val 100 105 110 Pro Leu Ala His Ser Ser Ser Ala Phe Thr Ile Thr Asp Gln Val Pro 115 120 125 Phe Ser Val Ser Val Ser Gln Leu Arg Ala Leu Asp Gly Gly Asn Lys 130 135 140 His Phe Leu Arg Asn Gln Pro Leu Thr Phe Ala Leu Gln Leu His Asp 145 150 155 160 Pro Ser Gly Tyr Leu Ala Glu Ala Asp Leu Ser Tyr Thr Trp Asp Phe 165 170 175 Gly Asp Ser Ser Gly Thr Leu Ile Ser Arg Ala Leu Val Val Thr His 180 185 190 Thr Tyr Leu Glu Pro Gly Pro Val Thr Ala Gln Val Val Leu Gln Ala 195 200 205 Ala Ile Pro Leu Thr Ser Cys Gly Ser Ser Pro Val Pro Gly Thr Thr 210 215 220 Asp Gly His Arg Pro Thr Ala Glu Ala Pro Asn Thr Thr Ala Gly Gln 225 230 235 240 Val Pro Thr Thr Glu Val Val Gly Thr Thr Pro Gly Gln Ala Pro Thr 245 250 255 Ala Glu Pro Ser Gly Thr Thr Ser Val Gln Val Pro Thr Thr Glu Val 260 265 270 Ile Ser Thr Ala Pro Val Gln Met Pro Thr Ala Glu Ser Thr Gly Met 275 280 285 Thr Pro Glu Lys Val Pro Val Ser Glu Val Met Gly Thr Thr Leu Ala 290 295 300 Glu Met Ser Thr Pro Glu Ala Thr Gly Met Thr Pro Ala Glu Val Ser 305 310 315 320 Ile Val Val Leu Ser Gly Thr Thr Ala Ala Gln Val Thr Thr Thr Glu 325 330 335 Trp Val Glu Thr Thr Ala Arg Glu Leu Pro Ile Pro Glu Pro Glu Gly 340 345 350 Pro Asp Ala Ser Ser Ile Met Ser Thr Glu Ser Ile Thr Gly Ser Leu 355 360 365 Gly Pro Leu Leu Asp Gly Thr Ala Thr Leu Arg Leu Val Lys Arg Gln 370 375 380 Val Pro Leu Asp Cys Val Leu Tyr Arg Tyr Gly Ser Phe Ser Val Thr 385 390 395 400 Leu Asp Ile Val Gln Gly Ile Glu Ser Ala Glu Ile Leu Gln Ala Val 405 410 415 Pro Ser Gly Glu Gly Asp Ala Phe Glu Leu Thr Val Ser Cys Gln Gly 420 425 430 Gly Leu Pro Lys Glu Ala Cys Met Glu Ile Ser Ser Pro Gly Cys Gln 435 440 445 Pro Pro Ala Gln Arg Leu Cys Gln Pro Val Leu Pro Ser Pro Ala Cys 450 455 460 Gln Leu Val Leu His Gln Ile Leu Lys Gly Gly Ser Gly Thr Tyr Cys 465 470 475 480 Leu Asn Val Ser Leu Ala Asp Thr Asn Ser Leu Ala Val Val Ser Thr 485 490 495 Gln Leu Ile Met Pro Gly Gln Glu Ala Gly Leu Gly Gln Val Pro Leu 500 505 510 Ile Val Gly Ile Leu Leu Val Leu Met Ala Val Val Leu Ala Ser Leu 515 520 525 Ile Tyr Arg Arg Arg Leu Met Lys Gln Asp Phe Ser Val Pro Gln Leu 530 535 540 Pro His Ser Ser Ser His Trp Leu Arg Leu Pro Arg Ile Phe Cys Ser 545 550 555 560 Cys Pro Ile Gly Glu Asn Ser Pro Leu Leu Ser Gly Gln Gln Val 565 570 575 <210> 276 <211> 668 <212> PRT <213> Homo sapiens <400> 276 Met Asp Leu Val Leu Lys Arg Cys Leu Leu His Leu Ala Val Ile Gly 1 5 10 15 Ala Leu Leu Ala Val Gly Ala Thr Lys Val Pro Arg Asn Gln Asp Trp 20 25 30 Leu Gly Val Ser Arg Gln Leu Arg Thr Lys Ala Trp Asn Arg Gln Leu 35 40 45 Tyr Pro Glu Trp Thr Glu Ala Gln Arg Leu Asp Cys Trp Arg Gly Gly 50 55 60 Gln Val Ser Leu Lys Val Ser Asn Asp Gly Pro Thr Leu Ile Gly Ala 65 70 75 80 Asn Ala Ser Phe Ser Ile Ala Leu Asn Phe Pro Gly Ser Gln Lys Val 85 90 95 Leu Pro Asp Gly Gln Val Ile Trp Val Asn Asn Thr Ile Ile Asn Gly 100 105 110 Ser Gln Val Trp Gly Gly Gln Pro Val Tyr Pro Gln Glu Thr Asp Asp 115 120 125 Ala Cys Ile Phe Pro Asp Gly Gly Pro Cys Pro Ser Gly Ser Trp Ser 130 135 140 Gln Lys Arg Ser Phe Val Tyr Val Trp Lys Thr Trp Gly Gln Tyr Trp 145 150 155 160 Gln Val Leu Gly Gly Pro Val Ser Gly Leu Ser Ile Gly Thr Gly Arg 165 170 175 Ala Met Leu Gly Thr His Thr Met Glu Val Thr Val Tyr His Arg Arg 180 185 190 Gly Ser Arg Ser Tyr Val Pro Leu Ala His Ser Ser Ser Ala Phe Thr 195 200 205 Ile Thr Asp Gln Val Pro Phe Ser Val Ser Val Ser Gln Leu Arg Ala 210 215 220 Leu Asp Gly Gly Asn Lys His Phe Leu Arg Asn Gln Pro Leu Thr Phe 225 230 235 240 Ala Leu Gln Leu His Asp Pro Ser Gly Tyr Leu Ala Glu Ala Asp Leu 245 250 255 Ser Tyr Thr Trp Asp Phe Gly Asp Ser Ser Gly Thr Leu Ile Ser Arg 260 265 270 Ala Leu Val Val Thr His Thr Tyr Leu Glu Pro Gly Pro Val Thr Ala 275 280 285 Gln Val Val Leu Gln Ala Ala Ile Pro Leu Thr Ser Cys Gly Ser Ser 290 295 300 Pro Val Pro Gly Thr Thr Asp Gly His Arg Pro Thr Ala Glu Ala Pro 305 310 315 320 Asn Thr Thr Ala Gly Gln Val Pro Thr Thr Glu Val Val Gly Thr Thr 325 330 335 Pro Gly Gln Ala Pro Thr Ala Glu Pro Ser Gly Thr Thr Ser Val Gln 340 345 350 Val Pro Thr Thr Glu Val Ile Ser Thr Ala Pro Val Gln Met Pro Thr 355 360 365 Ala Glu Ser Thr Gly Met Thr Pro Glu Lys Val Pro Val Ser Glu Val 370 375 380 Met Gly Thr Thr Leu Ala Glu Met Ser Thr Pro Glu Ala Thr Gly Met 385 390 395 400 Thr Pro Ala Glu Val Ser Ile Val Val Leu Ser Gly Thr Thr Ala Ala 405 410 415 Gln Val Thr Thr Thr Glu Trp Val Glu Thr Thr Ala Arg Glu Leu Pro 420 425 430 Ile Pro Glu Pro Glu Gly Pro Asp Ala Ser Ser Ile Met Ser Thr Glu 435 440 445 Ser Ile Thr Gly Ser Leu Gly Pro Leu Leu Asp Gly Thr Ala Thr Leu 450 455 460 Arg Leu Val Lys Arg Gln Val Pro Leu Asp Cys Val Leu Tyr Arg Tyr 465 470 475 480 Gly Ser Phe Ser Val Thr Leu Asp Ile Val Gln Gly Ile Glu Ser Ala 485 490 495 Glu Ile Leu Gln Ala Val Pro Ser Gly Glu Gly Asp Ala Phe Glu Leu 500 505 510 Thr Val Ser Cys Gln Gly Gly Leu Pro Lys Glu Ala Cys Met Glu Ile 515 520 525 Ser Ser Pro Gly Cys Gln Pro Pro Ala Gln Arg Leu Cys Gln Pro Val 530 535 540 Leu Pro Ser Pro Ala Cys Gln Leu Val Leu His Gln Ile Leu Lys Gly 545 550 555 560 Gly Ser Gly Thr Tyr Cys Leu Asn Val Ser Leu Ala Asp Thr Asn Ser 565 570 575 Leu Ala Val Val Ser Thr Gln Leu Ile Met Pro Val Pro Gly Ile Leu 580 585 590 Leu Thr Gly Gln Glu Ala Gly Leu Gly Gln Val Pro Leu Ile Val Gly 595 600 605 Ile Leu Leu Val Leu Met Ala Val Val Leu Ala Ser Leu Ile Tyr Arg 610 615 620 Arg Arg Leu Met Lys Gln Asp Phe Ser Val Pro Gln Leu Pro His Ser 625 630 635 640 Ser Ser His Trp Leu Arg Leu Pro Arg Ile Phe Cys Ser Cys Pro Ile 645 650 655 Gly Glu Asn Ser Pro Leu Leu Ser Gly Gln Gln Val 660 665 <210> 277 <211> 2195 <212> ADN <213> Homo sapiens <400> 277 cccagcgctc ctccccgcaa atgatcccgc cccaggggcc tatcccagtc cccccagtgc 60 ctttggttgc tggagggaag aacacaatgg atctggtgct aaaaagatgc cttcttcatt 120 tggctgtgat aggtgctttg ctggctgtgg gggctacaaa agtacccaga aaccaggact 180 ggcttggtgt ctcaaggcaa ctcagaacca aagcctggaa caggcagctg tatccagagt 240 ggacagaagc ccagagactt gactgctgga gaggtggtca agtgtccctc aaggtcagta 300 atgatgggcc tacactgatt ggtgcaaatg cctccttctc tattgccttg aacttccctg 360 gaagccaaaa ggtattgcca gatgggcagg ttatctgggt caacaatacc atcatcaatg 420 ggagccaggt gtggggagga cagccagtgt atccccagga aactgacgat gcctgcatct 480 tccctgatgg tggaccttgc ccatctggct cttggtctca gaagagaagc tttgtttatg 540 tctggaagac ctggggccaa tactggcaag ttctaggggg cccagtgtct gggctgagca 600 ttgggacagg cagggcaatg ctgggcacac acaccatgga agtgactgtc taccatcgcc 660 ggggatcccg gagctatgtg cctcttgctc attccagctc agccttcacc attactgacc 720 aggtgccttt ctccgtgagc gtgtcccagt tgcgggcctt ggatggaggg aacaagcact 780 tcctgagaaa tcagcctctg acctttgccc tccagctcca tgaccccagt ggctatctgg 840 ctgaagctga cctctcctac acctgggact ttggagacag tagtggaacc ctgatctctc 900 gggcacttgt ggtcactcat acttacctgg agcctggccc agtcactgcc caggtggtcc 960 tgcaggctgc cattcctctc acctcctgtg gctcctcccc agttccaggc accacagatg 1020 ggcacaggcc aactgcagag gcccctaaca ccacagctgg ccaagtgcct actacagaag 1080 ttgtgggtac tacacctggt caggcgccaa ctgcagagcc ctctggaacc acatctgtgc 1140 aggtgccaac cactgaagtc ataagcactg cacctgtgca gatgccaact gcagagagca 1200 caggtatgac acctgagaag gtgccagttt cagaggtcat gggtaccaca ctggcagaga 1260 tgtcaactcc agaggctaca ggtatgacac ctgcagaggt atcaattgtg gtgctttctg 1320 gaaccacagc tgcacaggta acaactacag agtgggtgga gaccacagct agagagctac 1380 ctatccctga gcctgaaggt ccagatgcca gctcaatcat gtctacggaa agtattacag 1440 gttccctggg ccccctgctg gatggtacag ccaccttaag gctggtgaag agacaagtcc 1500 ccctggattg tgttctgtat cgatatggtt ccttttccgt caccctggac attgtccagg 1560 gtattgaaag tgccgagatc ctgcaggctg tgccgtccgg tgagggggat gcatttgagc 1620 tgactgtgtc ctgccaaggc gggctgccca aggaagcctg catggagatc tcatcgccag 1680 ggtgccagcc ccctgcccag cggctgtgcc agcctgtgct acccagccca gcctgccagc 1740 tggttctgca ccagatactg aagggtggct cggggacata ctgcctcaat gtgtctctgg 1800 ctgataccaa cagcctggca gtggtcagca cccagcttat catgcctggt caagaagcag 1860 gccttgggca ggttccgctg atcgtgggca tcttgctggt gttgatggct gtggtccttg 1920 catctctgat atataggcgc agacttatga agcaagactt ctccgtaccc cagttgccac 1980 atagcagcag tcactggctg cgtctacccc gcatcttctg ctcttgtccc attggtgaga 2040 acagccccct cctcagtggg cagcaggtct gagtactctc atatgatgct gtgattttcc 2100 tggagttgac agaaacacct atatttcccc cagtcttccc tgggagacta ctattaactg 2160 aaataaatac tcagagcctg aaaaaaaaaa aaaaa 2195 <210> 278 <211> 1902 <212> ADN <213> Homo sapiens <400> 278 gggcctatcc cagtcccccc agtgcctttg gttgctggag ggaagaacac aatggatctg 60 gtgctaaaaa gatgccttct tcatttggct gtgataggtg ctttgctggc tgtgggggct 120 acaaaaggga gccaggtgtg gggaggacag ccagtgtatc cccaggaaac tgacgatgcc 180 tgcatcttcc ctgatggtgg accttgccca tctggctctt ggtctcagaa gagaagcttt 240 gtttatgtct ggaagacctg gggccaatac tggcaagttc tagggggccc agtgtctggg 300 ctgagcattg ggacaggcag ggcaatgctg ggcacacaca ccatggaagt gactgtctac 360 catcgccggg gatcccggag ctatgtgcct cttgctcatt ccagctcagc cttcaccatt 420 actgaccagg tgcctttctc cgtgagcgtg tcccagttgc gggccttgga tggagggaac 480 aagcacttcc tgagaaatca gcctctgacc tttgccctcc agctccatga ccccagtggc 540 tatctggctg aagctgacct ctcctacacc tgggactttg gagacagtag tggaaccctg 600 atctctcggg cacttgtggt cactcatact tacctggagc ctggcccagt cactgcccag 660 gtggtcctgc aggctgccat tcctctcacc tcctgtggct cctccccagt tccaggcacc 720 acagatgggc acaggccaac tgcagaggcc cctaacacca cagctggcca agtgcctact 780 acagaagttg tgggtactac acctggtcag gcgccaactg cagagccctc tggaaccaca 840 tctgtgcagg tgccaaccac tgaagtcata agcactgcac ctgtgcagat gccaactgca 900 gagagcacag gtatgacacc tgagaaggtg ccagtttcag aggtcatggg taccacactg 960 gcagagatgt caactccaga ggctacaggt atgacacctg cagaggtatc aattgtggtg 1020 ctttctggaa ccacagctgc acaggtaaca actacagagt gggtggagac cacagctaga 1080 gagctaccta tccctgagcc tgaaggtcca gatgccagct caatcatgtc tacggaaagt 1140 attacaggtt ccctgggccc cctgctggat ggtacagcca ccttaaggct ggtgaagaga 1200 caagtccccc tggattgtgt tctgtatcga tatggttcct tttccgtcac cctggacatt 1260 gtccagggta ttgaaagtgc cgagatcctg caggctgtgc cgtccggtga gggggatgca 1320 tttgagctga ctgtgtcctg ccaaggcggg ctgcccaagg aagcctgcat ggagatctca 1380 tcgccagggt gccagccccc tgcccagcgg ctgtgccagc ctgtgctacc cagcccagcc 1440 tgccagctgg ttctgcacca gatactgaag ggtggctcgg ggacatactg cctcaatgtg 1500 tctctggctg ataccaacag cctggcagtg gtcagcaccc agcttatcat gcctggtcaa 1560 gaagcaggcc ttgggcaggt tccgctgatc gtgggcatct tgctggtgtt gatggctgtg 1620 gtccttgcat ctctgatata taggcgcaga cttatgaagc aagacttctc cgtaccccag 1680 ttgccacata gcagcagtca ctggctgcgt ctaccccgca tcttctgctc ttgtcccatt 1740 ggtgagaaca gccccctcct cagtgggcag caggtctgag tactctcata tgatgctgtg 1800 attttcctgg agttgacaga aacacctata tttcccccag tcttccctgg gagactacta 1860 ttaactgaaa taaatactca gagcctgaaa aaaaaaaaaa aa 1902 <210> 279 <211> 2181 <212> ADN <213> Homo sapiens <400> 279 gggcctatcc cagtcccccc agtgcctttg gttgctggag ggaagaacac aatggatctg 60 gtgctaaaaa gatgccttct tcatttggct gtgataggtg ctttgctggc tgtgggggct 120 acaaaagtac ccagaaacca ggactggctt ggtgtctcaa ggcaactcag aaccaaagcc 180 tggaacaggc agctgtatcc agagtggaca gaagcccaga gacttgactg ctggagaggt 240 ggtcaagtgt ccctcaaggt cagtaatgat gggcctacac tgattggtgc aaatgcctcc 300 ttctctattg ccttgaactt ccctggaagc caaaaggtat tgccagatgg gcaggttatc 360 tgggtcaaca ataccatcat caatgggagc caggtgtggg gaggacagcc agtgtatccc 420 caggaaactg acgatgcctg catcttccct gatggtggac cttgcccatc tggctcttgg 480 tctcagaaga gaagctttgt ttatgtctgg aagacctggg gccaatactg gcaagttcta 540 gggggcccag tgtctgggct gagcattggg acaggcaggg caatgctggg cacacacacc 600 atggaagtga ctgtctacca tcgccgggga tcccggagct atgtgcctct tgctcattcc 660 agctcagcct tcaccattac tgaccaggtg cctttctccg tgagcgtgtc ccagttgcgg 720 gccttggatg gagggaacaa gcacttcctg agaaatcagc ctctgacctt tgccctccag 780 ctccatgacc ccagtggcta tctggctgaa gctgacctct cctacacctg ggactttgga 840 gacagtagtg gaaccctgat ctctcgggca cttgtggtca ctcatactta cctggagcct 900 ggcccagtca ctgcccaggt ggtcctgcag gctgccattc ctctcacctc ctgtggctcc 960 tccccagttc caggcaccac agatgggcac aggccaactg cagaggcccc taacaccaca 1020 gctggccaag tgcctactac agaagttgtg ggtactacac ctggtcaggc gccaactgca 1080 gagccctctg gaaccacatc tgtgcaggtg ccaaccactg aagtcataag cactgcacct 1140 gtgcagatgc caactgcaga gagcacaggt atgacacctg agaaggtgcc agtttcagag 1200 gtcatgggta ccacactggc agagatgtca actccagagg ctacaggtat gacacctgca 1260 gaggtatcaa ttgtggtgct ttctggaacc acagctgcac aggtaacaac tacagagtgg 1320 gtggagacca cagctagaga gctacctatc cctgagcctg aaggtccaga tgccagctca 1380 atcatgtcta cggaaagtat tacaggttcc ctgggccccc tgctggatgg tacagccacc 1440 ttaaggctgg tgaagagaca agtccccctg gattgtgttc tgtatcgata tggttccttt 1500 tccgtcaccc tggacattgt ccagggtatt gaaagtgccg agatcctgca ggctgtgccg 1560 tccggtgagg gggatgcatt tgagctgact gtgtcctgcc aaggcgggct gcccaaggaa 1620 gcctgcatgg agatctcatc gccagggtgc cagccccctg cccagcggct gtgccagcct 1680 gtgctaccca gcccagcctg ccagctggtt ctgcaccaga tactgaaggg tggctcgggg 1740 acatactgcc tcaatgtgtc tctggctgat accaacagcc tggcagtggt cagcacccag 1800 cttatcatgc ctgtgcctgg gattcttctc acaggtcaag aagcaggcct tgggcaggtt 1860 ccgctgatcg tgggcatctt gctggtgttg atggctgtgg tccttgcatc tctgatatat 1920 aggcgcagac ttatgaagca agacttctcc gtaccccagt tgccacatag cagcagtcac 1980 tggctgcgtc taccccgcat cttctgctct tgtcccattg gtgagaacag ccccctcctc 2040 agtgggcagc aggtctgagt actctcatat gatgctgtga ttttcctgga gttgacagaa 2100 acacctatat ttcccccagt cttccctggg agactactat taactgaaat aaatactcag 2160 agcctgaaaa aaaaaaaaaa a 2181 <210> 280 <211> 2041 <212> ADN <213> Homo sapiens <400> 280 gggcctatcc cagtcccccc agtgcctttg gttgctggag ggaagaacac aatggatctg 60 gtgctaaaaa gatgccttct tcatttggct gtgataggtg ctttgctggc tgtgggggct 120 acaaaagtac ccagaaacca ggactggctt ggtgtctcaa ggcaactcag aaccaaagcc 180 tggaacaggc agctgtatcc agagtggaca gaagcccaga gacttgactg ctggagaggt 240 ggtcaagtgt ccctcaaggt cagtaatgat gggcctacac tgattggtgc aaatgcctcc 300 ttctctattg ccttgaactt ccctggaagc caaaaggtat tgccagatgg gcaggttatc 360 tgggtcaaca ataccatcat caatgggagc caggtgtggg gaggacagcc agtgtatccc 420 caggaaactg acgatgcctg catcttccct gatggtggac cttgcccatc tggctcttgg 480 tctcagaaga gaagctttgt ttatgtctgg aagacctggg gccaatactg gcaagttcta 540 gggggcccag tgtctgggct gagcattggg acaggcaggg caatgctggg cacacacacc 600 atggaagtga ctgtctacca tcgccgggga tcccggagct atgtgcctct tgctcattcc 660 agctcagcct tcaccattac tgaccaggtg cctttctccg tgagcgtgtc ccagttgcgg 720 gccttggatg gagggaacaa gcacttcctg agaaatcagc ctctgacctt tgccctccag 780 ctccatgacc ccagtggcta tctggctgaa gctgacctct cctacacctg ggactttgga 840 gacagtagtg gaaccctgat ctctcgggca cttgtggtca ctcatactta cctggagcct 900 ggcccagtca ctgcccaggt ggtcctgcag gctgccattc ctctcacctc ctgtggctcc 960 tccccagttc caggcaccac agatgggcac aggccaactg cagaggcccc taacaccaca 1020 gctggccaag tgcctactac agaagttgtg ggtactacac ctggtcaggc gccaactgca 1080 gagccctctg gaaccacatc tgtgcaggtg ccaaccactg aagtcataag cactgcacct 1140 gtgcagatgc caactgcaga gagcacagct gcacaggtaa caactacaga gtgggtggag 1200 accacagcta gagagctacc tatccctgag cctgaaggtc cagatgccag ctcaatcatg 1260 tctacggaaa gtattacagg ttccctgggc cccctgctgg atggtacagc caccttaagg 1320 ctggtgaaga gacaagtccc cctggattgt gttctgtatc gatatggttc cttttccgtc 1380 accctggaca ttgtccaggg tattgaaagt gccgagatcc tgcaggctgt gccgtccggt 1440 gagggggatg catttgagct gactgtgtcc tgccaaggcg ggctgcccaa ggaagcctgc 1500 atggagatct catcgccagg gtgccagccc cctgcccagc ggctgtgcca gcctgtgcta 1560 cccagcccag cctgccagct ggttctgcac cagatactga agggtggctc ggggacatac 1620 tgcctcaatg tgtctctggc tgataccaac agcctggcag tggtcagcac ccagcttatc 1680 atgcctgtgc ctgggattct tctcacaggt caagaagcag gccttgggca ggttccgctg 1740 atcgtgggca tcttgctggt gttgatggct gtggtccttg catctctgat atataggcgc 1800 agacttatga agcaagactt ctccgtaccc cagttgccac atagcagcag tcactggctg 1860 cgtctacccc gcatcttctg ctcttgtccc attggtgaga acagccccct cctcagtggg 1920 cagcaggtct gagtactctc atatgatgct gtgattttcc tggagttgac agaaacacct 1980 atatttcccc cagtcttccc tgggagacta ctattaactg aaataaatac tcagagcctg 2040 a 2041 <210> 281 <211> 2020 <212> ADN <213> Homo sapiens <400> 281 gggcctatcc cagtcccccc agtgcctttg gttgctggag ggaagaacac aatggatctg 60 gtgctaaaaa gatgccttct tcatttggct gtgataggtg ctttgctggc tgtgggggct 120 acaaaagtac ccagaaacca ggactggctt ggtgtctcaa ggcaactcag aaccaaagcc 180 tggaacaggc agctgtatcc agagtggaca gaagcccaga gacttgactg ctggagaggt 240 ggtcaagtgt ccctcaaggt cagtaatgat gggcctacac tgattggtgc aaatgcctcc 300 ttctctattg ccttgaactt ccctggaagc caaaaggtat tgccagatgg gcaggttatc 360 tgggtcaaca ataccatcat caatgggagc caggtgtggg gaggacagcc agtgtatccc 420 caggaaactg acgatgcctg catcttccct gatggtggac cttgcccatc tggctcttgg 480 tctcagaaga gaagctttgt ttatgtctgg aagacctggg gccaatactg gcaagttcta 540 gggggcccag tgtctgggct gagcattggg acaggcaggg caatgctggg cacacacacc 600 atggaagtga ctgtctacca tcgccgggga tcccggagct atgtgcctct tgctcattcc 660 agctcagcct tcaccattac tgaccaggtg cctttctccg tgagcgtgtc ccagttgcgg 720 gccttggatg gagggaacaa gcacttcctg agaaatcagc ctctgacctt tgccctccag 780 ctccatgacc ccagtggcta tctggctgaa gctgacctct cctacacctg ggactttgga 840 gacagtagtg gaaccctgat ctctcgggca cttgtggtca ctcatactta cctggagcct 900 ggcccagtca ctgcccaggt ggtcctgcag gctgccattc ctctcacctc ctgtggctcc 960 tccccagttc caggcaccac agatgggcac aggccaactg cagaggcccc taacaccaca 1020 gctggccaag tgcctactac agaagttgtg ggtactacac ctggtcaggc gccaactgca 1080 gagccctctg gaaccacatc tgtgcaggtg ccaaccactg aagtcataag cactgcacct 1140 gtgcagatgc caactgcaga gagcacagct gcacaggtaa caactacaga gtgggtggag 1200 accacagcta gagagctacc tatccctgag cctgaaggtc cagatgccag ctcaatcatg 1260 tctacggaaa gtattacagg ttccctgggc cccctgctgg atggtacagc caccttaagg 1320 ctggtgaaga gacaagtccc cctggattgt gttctgtatc gatatggttc cttttccgtc 1380 accctggaca ttgtccaggg tattgaaagt gccgagatcc tgcaggctgt gccgtccggt 1440 gagggggatg catttgagct gactgtgtcc tgccaaggcg ggctgcccaa ggaagcctgc 1500 atggagatct catcgccagg gtgccagccc cctgcccagc ggctgtgcca gcctgtgcta 1560 cccagcccag cctgccagct ggttctgcac cagatactga agggtggctc ggggacatac 1620 tgcctcaatg tgtctctggc tgataccaac agcctggcag tggtcagcac ccagcttatc 1680 atgcctggtc aagaagcagg ccttgggcag gttccgctga tcgtgggcat cttgctggtg 1740 ttgatggctg tggtccttgc atctctgata tataggcgca gacttatgaa gcaagacttc 1800 tccgtacccc agttgccaca tagcagcagt cactggctgc gtctaccccg catcttctgc 1860 tcttgtccca ttggtgagaa cagccccctc ctcagtgggc agcaggtctg agtactctca 1920 tatgatgctg tgattttcct ggagttgaca gaaacaccta tatttccccc agtcttccct 1980 gggagactac tattaactga aataaatact cagagcctga 2020 <210> 282 <211> 22 <212> PRT <213> Secuencia Artificial <220> <221> source <223> /note="Descripción de Secuencia Artificial: Péptido Sintético <400> 282 Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Leu Tyr Arg Ser Pro 1 5 10 15 Ala Met Pro Glu Asn Leu 20 2