LISTADO DE SECUENCIAS <110> StrideBio, Inc. <120> VECTORES VIRALES RECOMBINANTES Y ÁCIDOS NUCLEICOS PARA PRODUCIRLOS <130> STRD-011/01WO 331843-2071 <150> US 62/770,202 <151> 2018-11-21 <160> 70 <170> PatentIn versión 3.5 <210> 1 <211> 141 <212> ADN <213> Dependoparvovirus Adenoasociado virus serotipo 2 <400> 1 cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc 60 gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca 120 actccatcac taggggttcc t 141 <210> 2 <211> 113 <212> ADN <213> Secuencia artificial <220> <223> ITR 3’ <400> 2 ccactccctc tctgcgcgct cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac 60 gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc gcgcagagag gga 113 <210> 3 <211> 141 <212> ADN <213> Secuencia artificial <220> <223> ITR 3’ <400> 3 aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg 60 ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc 120 gagcgcgcag ctgcctgcag g 141 <210> 4 <211> 380 <212> ADN <213> Desconocida <220> <223> Cytomegalovirus sp. <400> 4 gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc 60 catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca 120 acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga 180 ctttccattg acgtcaatgg gtggactatt tacggtaaac tgcccacttg gcagtacatc 240 aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct 300 ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat 360 tagtcatcgc tattaccatg 380 <210> 5 <211> 286 <212> ADN <213> Desconocida <220> <223> Cytomegalovirus sp. <400> 5 cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt 60 gacgtcaata gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg 120 gtaaactgcc cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga 180 cgtcaatgac ggtaaatggc ccgcctggca ttgtgcccag tacatgacct tatgggactt 240 tcctacttgg cagtacatct acgtattagt catcgctatt accatg 286 <210> 6 <211> 276 <212> ADN <213> Gallus gallus <400> 6 tcgaggtgag ccccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa 60 ttttgtattt atttattttt taattatttt gtgcagcgat gggggcgggg gggggggggg 120 cgcgcgccag gcggggcggg gcggggcgag gggcggggcg gggcgaggcg gagaggtgcg 180 gcggcagcca atcagagcgg cgcgctccga aagtttcctt ttatggcgag gcggcggcgg 240 cggcggccct ataaaaagcg aagcgcgcgg cgggcg 276 <210> 7 <211> 227 <212> ADN <213> Homo sapiens <400> 7 gcccgtcagt gggcagagcg cacatcgccc acagtccccg agaagttggg gggaggggtc 60 ggcaattgaa ccggtgccta gagaaggtgg cgcggggtaa actgggaaag tgatgtcgtg 120 tactggctcc gcctttttcc cgagggtggg ggagaaccgt atataagtgc agtagtcgcc 180 gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac gcgtaag 227 <210> 8 <211> 1182 <212> ADN <213> Homo sapiens <400> 8 gctccggtgc ccgtcagtgg gcagagcgca catcgcccac agtccccgag aagttggggg 60 gaggggtcgg caattgaacc ggtgcctaga gaaggtggcg cggggtaaac tgggaaagtg 120 atgtcgtgta ctggctccgc ctttttcccg agggtggggg agaaccgtat ataagtgcag 180 tagtcgccgt gaacgttctt tttcgcaacg ggtttgccgc cagaacacag gtaagtgccg 240 tgtgtggttc ccgcgggcct ggcctcttta cgggttatgg cccttgcgtg ccttgaatta 300 cttccacgcc cctggctgca gtacgtgatt cttgatcccg agcttcgggt tggaagtggg 360 tgggagagtt cgaggccttg cgcttaagga gccccttcgc ctcgtgcttg agttgaggcc 420 tggcctgggc gctggggccg ccgcgtgcga atctggtggc accttcgcgc ctgtctcgct 480 gctttcgata agtctctagc catttaaaat ttttgatgac ctgctgcgac gctttttttc 540 tggcaagata gtcttgtaaa tgcgggccaa gatctgcaca ctggtatttc ggtttttggg 600 gccgcgggcg gcgacggggc ccgtgcgtcc cagcgcacat gttcggcgag gcggggcctg 660 cgagcgcggc caccgagaat cggacggggg tagtctcaag ctggccggcc tgctctggtg 720 cctggcctcg cgccgccgtg tatcgccccg ccctgggcgg caaggctggc ccggtcggca 780 ccagttgcgt gagcggaaag atggccgctt cccggccctg ctgcagggag ctcaaaatgg 840 aggacgcggc gctcgggaga gcgggcgggt gagtcaccca cacaaaggaa aagggccttt 900 ccgtcctcag ccgtcgcttc atgtgactcc acggagtacc gggcgccgtc caggcacctc 960 gattagttct cgagcttttg gagtacgtcg tctttaggtt ggggggaggg gttttatgcg 1020 atggagtttc cccacactga gtgggtggag actgaagtta ggccagcttg gcacttgatg 1080 taattctcct tggaatttgc cctttttgag tttggatctt ggttcattct caagcctcag 1140 acagtggttc aaagtttttt tcttccattt caggtgtcgt ga 1182 <210> 9 <211> 212 <212> ADN <213> Secuencia artificial <220> <223> Promotor del núcleo de EF1a <400> 9 gggcagagcg cacatcgccc acagtccccg agaagttggg gggaggggtc ggcaattgaa 60 ccggtgccta gagaaggtgg cgcggggtaa actgggaaag tgatgtcgtg tactggctcc 120 gcctttttcc cgagggtggg ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc 180 tttttcgcaa cgggtttgcc gccagaacac gc 212 <210> 10 <211> 511 <212> ADN <213> Homo sapiens <400> 10 ggggttgggg ttgcgccttt tccaaggcag ccctgggttt gcgcagggac gcggctgctc 60 tgggcgtggt tccgggaaac gcagcggcgc cgaccctggg tctcgcacat tcttcacgtc 120 cgttcgcagc gtcacccgga tcttcgccgc tacccttgtg ggccccccgg cgacgcttcc 180 tgctccgccc ctaagtcggg aaggttcctt gcggttcgcg gcgtgccgga cgtgacaaac 240 ggaagccgca cgtctcacta gtaccctcgc agacggacag cgccagggag caatggcagc 300 gcgccgaccg cgatgggctg tggccaatag cggctgctca gcagggcgcg ccgagagcag 360 cggccgggaa ggggcggtgc gggaggcggg gtgtggggcg gtagtgtggg ccctgttcct 420 gcccgcgcgg tgttccgcat tctgcaagcc tccggagcgc acgtcggcag tcggctccct 480 cgttgaccga atcaccgacc tctctcccca g 511 <210> 11 <211> 240 <212> ADN <213> Homo sapiens <400> 11 cggctggggc tgagggtgag ggtcccgttt ccccaaaggc ctagcctggg gttccagcca 60 caagccctac cgggcagcgc ccggccccgc ccctccaggc ctggcactcg tcctcaacca 120 agatggcgcg gatggcttca ggcgcatcac gacaccggcg cgtcacgcga cccgccctac 180 gggcacctcc cgcgcttttc ttagcgccgc agacggtggc cgagcggggg accgggaagc 240 <210> 12 <211> 379 <212> ADN <213> Homo sapiens <400> 12 attcctgctg ggaaaagcaa gtggaggtgc tccttgaaga aacaggggga tcccaccgat 60 ctcaggggtt ctgttctggc ctgcggccct ggatcgtcca gcctgggtcg gggtggggag 120 cagacctcgc ccttatcggc tggggctgag ggtgagggtc ccgtttcccc aaaggcctag 180 cctggggttc cagccacaag ccctaccggg cagcgcccgg ccccgcccct ccaggcctgg 240 cactcgtcct caaccaagat ggcgcggatg gcttcaggcg catcacgaca ccggcgcgtc 300 acgcgacccg ccctacgggc acctcccgcg cttttcttag cgccgcagac ggtggtcgag 360 cgggggaccg ggaagctta 379 <210> 13 <211> 229 <212> ADN <213> Secuencia artificial <220> <223> Secuencia intrónica - Híbrida <400> 13 ggagtcgctg cgacgctgcc ttcgccccgt gccccgctcc gccgccgcct cgcgccgccc 60 gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg gcccttctcc 120 tccgggctgt aattagctga gcaagaggta agggtttaag ggatggttgg ttggtggggt 180 attaatgttt aattacctgg agcacctgcc tgaaatcact ttttttcag 229 <210> 14 <211> 476 <212> ADN <213> Homo sapiens <400> 14 gtgagtctat gggacccttg atgttttctt tccccttctt ttctatggtt aagttcatgt 60 cataggaagg ggagaagtaa cagggtacac atattgacca aatcagggta attttgcatt 120 tgtaatttta aaaaatgctt tcttctttta atatactttt ttgtttatct tatttctaat 180 actttcccta atctctttct ttcagggcaa taatgataca atgtatcatg cctctttgca 240 ccattctaaa gaataacagt gataatttct gggttaaggc aatagcaata tttctgcata 300 taaatatttc tgcatataaa ttgtaactga tgtaagaggt ttcatattgc taatagcagc 360 tacaatccag ctaccattct gcttttattt tatggttggg ataaggctgg attattctga 420 gtccaagcta ggcccttttg ctaatcatgt tcatacctct tatcttcctc ccacag 476 <210> 15 <211> 133 <212> ADN <213> Secuencia artificial <220> <223> Secuencia intrónica - Quimérica <400> 15 gtaagtatca aggttacaag acaggtttaa ggagaccaat agaaactggg cttgtcgaga 60 cagagaagac tcttgcgttt ctgataggca cctattggtc ttactgacat ccactttgcc 120 tttctctcca cag 133 <210> 16 <211> 97 <212> ADN <213> Virus del simio 40 <400> 16 gtaagtttag tctttttgtc ttttatttca ggtcccggat ccggtggtgg tgcaaatcaa 60 agaactgctc ctcagtggat gttgccttta cttctag 97 <210> 17 <211> 12 <212> ADN <213> Secuencia artificial <220> <223> Secuencia de Kozak modificada <400> 17 acccggagca gc 12 <210> 18 <211> 9 <212> ADN <213> Secuencia artificial <220> <223> Secuencia de Kozak de consenso <400> 18 acagccacc 9 <210> 19 <211> 633 <212> ADN <213> Homo sapiens <400> 19 atgtggactc tcgggcgccg cgcagtagcc ggcctcctgg cgtcacccag cccagcccag 60 gcccagaccc tcacccgggt cccgcggccg gcagagttgg ccccactctg cggccgccgt 120 ggcctgcgca ccgacatcga tgcgacctgc acgccccgcc gcgcaagttc gaaccaacgt 180 ggcctcaacc agatttggaa tgtcaaaaag cagagtgtct atttgatgaa tttgaggaaa 240 tctggaactt tgggccaccc aggctctcta gatgagacca cctatgaaag actagcagag 300 gaaacgctgg actctttagc agagtttttt gaagaccttg cagacaagcc atacacgttt 360 gaggactatg atgtctcctt tgggagtggt gtcttaactg tcaaactggg tggagatcta 420 ggaacctatg tgatcaacaa gcagacgcca aacaagcaaa tctggctatc ttctccatcc 480 agtggaccta agcgttatga ctggactggg aaaaactggg tgtactccca cgacggcgtg 540 tccctccatg agctgctggc cgcagagctc actaaagcct taaaaaccaa actggacttg 600 tcttccttgg cctattccgg aaaagatgct tga 633 <210> 20 <211> 633 <212> ADN <213> Secuencia artificial <220> <223> ADNc de frataxina, Optimizada por CpG <400> 20 atgtggactc tggggaggag agcagtagct ggcctcctgg catcacccag cccagcccag 60 gcccagaccc tcaccagggt ccctagacca gcagagttgg ccccactctg tggcaggaga 120 ggcctgagga cagacattga tgccacctgc acccccagga gagcaagttc caaccaaaga 180 ggcctcaacc agatttggaa tgtcaaaaag cagagtgtct atttgatgaa tttgaggaaa 240 tctggaactt tgggccaccc aggctctcta gatgagacca cctatgaaag actagcagag 300 gaaacactgg actctttagc agagtttttt gaagaccttg cagacaagcc atacaccttt 360 gaggactatg atgtctcctt tgggagtggt gtcttaactg tcaaactggg tggagatcta 420 ggaacctatg tgatcaacaa gcagactcca aacaagcaaa tctggctatc ttctccatcc 480 agtggaccta agaggtatga ctggactggg aaaaactggg tgtactccca tgatggagtg 540 tccctccatg agctgctggc tgcagagctc actaaagcct taaaaaccaa actggacttg 600 tcttccttgg cctattctgg aaaagatgct tga 633 <210> 21 <211> 225 <212> ADN <213> Bos taurus <400> 21 ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc 60 tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc 120 tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt 180 gggaagacaa tagcaggcat gctggggatg cggtgggctc tatgg 225 <210> 22 <211> 477 <212> ADN <213> Homo sapiens <400> 22 gggtggcatc cctgtgaccc ctccccagtg cctctcctgg ccctggaagt tgccactcca 60 gtgcccacca gccttgtcct aataaaatta agttgcatca ttttgtctga ctaggtgtcc 120 ttctataata ttatggggtg gaggggggtg gtatggagca aggggcaagt tgggaagaca 180 acctgtaggg cctgcggggt ctattgggaa ccaagctgga gtgcagtggc acaatcttgg 240 ctcactgcaa tctccgcctc ctgggttcaa gcgattctcc tgcctcagcc tcccgagttg 300 ttgggattcc aggcatgcat gaccaggctc agctaatttt tgtttttttg gtagagacgg 360 ggtttcacca tattggccag gctggtctcc aactcctaat ctcaggtgat ctacccacct 420 tggcctccca aattgctggg attacaggcg tgaaccactg ctcccttccc tgtcctt 477 <210> 23 <211> 395 <212> ADN <213> Secuencia artificial <220> <223> señal de poliadenilación de beta globina humana (orientación inversa) <400> 23 taaaatacag catagcaaaa ctttaacctc caaatcaagc ctctacttga atccttttct 60 gagggatgaa taaggcatag gcatcagggg ctgttgccaa tgtgcattag ctgtttgcag 120 cctcaccttc tttcatggag tttaagatat agtgtatttt cccaaggttt gaactagctc 180 ttcatttctt tatgttttaa atgcactgac ctcccacatt ccctttttag taaaatattc 240 agaaataatt taaatacatc attgcaatga aaataaatgt tttttattag gcagaatcca 300 gatgctcaag gcccttcata atatccccca gtttagtagt tggacttagg gaacaaagga 360 acctttaata gaaattggac agcaagaaag cgagc 395 <210> 24 <211> 56 <212> ADN <213> Oryctolagus cuniculus <400> 24 aataaaggaa atttattttc attgcaatag tgtgttggaa ttttttgtgt ctctca 56 <210> 25 <211> 133 <212> ADN <213> Secuencia artificial <220> <223> Intrón quimérico de relleno <400> 25 gtaagtatca aggttacaag acaggtttaa ggagaccaat agaaactggg cttgtcgaga 60 cagagaagac tcttgcgttt ctgataggca cctattggtc ttactgacat ccactttgcc 120 tttctctcca cag 133 <210> 26 <211> 500 <212> ADN <213> Secuencia artificial <220> <223> A1AT de relleno <400> 26 agagacacag tttttgctct ggtgaattac atcttcttta aaggcaaatg ggagagaccc 60 tttgaagtca aggacacaga ggaagaggac ttcctagtgg accaggtgac caccttgaag 120 gtgcctatgt aaaagcattt aggcatgttt aacatccagc actgtaagaa gctgtccagc 180 tgggtgctgc tgtaaaaata cctgggcaat gccaccacca tcttcttcct gcctgatgag 240 gggaaactac agcacctgga aaatgaactc acccactata ttatcaccaa gttcctggaa 300 aatgaagaca gaaggtctgc cagcttacat ttacccaaac tgtcaattac tggaacctat 360 gatctgaaga gcttcctggg tcaactgggc atcactaagg tcttcagcaa tggggctgac 420 ctctcctggg tcacagagga ggcacccctg aagctctcca aggccttgca taaggctgtg 480 ctgaccatca ataagaaagg 500 <210> 27 <211> 502 <212> ADN <213> Homo sapiens <400> 27 taagtttttg tatgaatatg caagaaggca tcctgattac tctgtcttgc tgctgctgag 60 acttgccaag acctatgaaa ccactctaga gaagtgctgt gcctctgcag atcctcatga 120 atgctatgcc aaagtgttca gtgaatttaa acctcttgtg gaagagcctc agaatttaat 180 caaacaaaat tgtgagcttt ttgagcagct tggagagtac aaattccaga atgcactatt 240 agttctttac accaagaaag taccccaagt gtcaactcca actcttgtag aggtctcaag 300 aaacctagga aaagtgggca gcaaatgttg taaacatcct gaagcaaaaa gaatgccctg 360 tgcagaagac tatctatcct tggtcctgaa ccagttatgt gtgttgcatg agaaaacacc 420 agtaagtgac agagtcacca aatgctgcac agaatccttg gtgaacaggc aaccatgctt 480 ttcagctctg gaagttgatg aa 502 <210> 28 <211> 2226 <212> ADN <213> Secuencia artificial <220> <223> Casete de transferencia de AAV <400> 28 cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc 60 gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca 120 actccatcac taggggttcc ttgcgtcgac aggcctccta ggcggaccgc ttgcatgcac 180 gcgttcgcga agtactcacg tggacattga ttattgacta gttattaata gtaatcaatt 240 acggggtcat tagttcatag cccatatatg gagttccgcg ttacataact tacggtaaat 300 ggcccgcctg gctgaccgcc caacgacccc cgcccattga cgtcaataat gacgtatgtt 360 cccatagtaa cgccaatagg gactttccat tgacgtcaat gggtggacta tttacggtaa 420 actgcccact tggcagtaca tcaagtgtat catatgccaa gtacgccccc tattgacgtc 480 aatgacggta aatggcccgc ctggcattat gcccagtaca tgaccttatg ggactttcct 540 acttggcagt acatctacgt attagtcatc gctattacca tgggtcgagg tgagccccac 600 gttctgcttc actctcccca tctccccccc ctccccaccc ccaattttgt atttatttat 660 tttttaatta ttttgtgcag cgatgggggc gggggggggg ggggcgcgcg ccaggcgggg 720 cggggcgggg cgaggggcgg ggcggggcga ggcggagagg tgcggcggca gccaatcaga 780 gcggcgcgct ccgaaagttt ccttttatgg cgaggcggcg gcggcggcgg ccctataaaa 840 agcgaagcgc gcggcgggcg ggagtcgctg cgacgctgcc ttcgccccgt gccccgctcc 900 gccgccgcct cgcgccgccc gccccggctc tgactgaccg cgttactccc acaggtgagc 960 gggcgggacg gcccttctcc tccgggctgt aattagctga gcaagaggta agggtttaag 1020 ggatggttgg ttggtggggt attaatgttt aattacctgg agcacctgcc tgaaatcact 1080 ttttttcagg ttggaccggt acccggagca gcatgtggac tctcgggcgc cgcgcagtag 1140 ccggcctcct ggcgtcaccc agcccagccc aggcccagac cctcacccgg gtcccgcggc 1200 cggcagagtt ggccccactc tgcggccgcc gtggcctgcg caccgacatc gatgcgacct 1260 gcacgccccg ccgcgcaagt tcgaaccaac gtggcctcaa ccagatttgg aatgtcaaaa 1320 agcagagtgt ctatttgatg aatttgagga aatctggaac tttgggccac ccaggctctc 1380 tagatgagac cacctatgaa agactagcag aggaaacgct ggactcttta gcagagtttt 1440 ttgaagacct tgcagacaag ccatacacgt ttgaggacta tgatgtctcc tttgggagtg 1500 gtgtcttaac tgtcaaactg ggtggagatc taggaaccta tgtgatcaac aagcagacgc 1560 caaacaagca aatctggcta tcttctccat ccagtggacc taagcgttat gactggactg 1620 ggaaaaactg ggtgtactcc cacgacggcg tgtccctcca tgagctgctg gccgcagagc 1680 tcactaaagc cttaaaaacc aaactggact tgtcttcctt ggcctattcc ggaaaagatg 1740 cttgattcta ggatccgact gcaggtaggt ttaaacaagc ttggtaccgt gattaatctt 1800 cgaatgactg acctgtgcct tctagttgcc agccatctgt tgtttgcccc tcccccgtgc 1860 cttccttgac cctggaaggt gccactccca ctgtcctttc ctaataaaat gaggaaattg 1920 catcgcattg tctgagtagg tgtcattcta ttctgggggg tggggtgggg caggacagca 1980 agggggagga ttgggaagac aatagcaggc atgctgggga tgcggtgggc tctatggaga 2040 tctgtgtgtt ggttttttgt gtgcgtacgg agctaccagg tctcgagcca tgggcgcgcc 2100 atcgatgact agtccactcc ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca 2160 aaggtcgccc gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg agcgcgcaga 2220 gaggga 2226 <210> 29 <211> 2089 <212> ADN <213> Secuencia artificial <220> <223> Casete de transferencia de AAV <400> 29 cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc 60 gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca 120 actccatcac taggggttcc ttgcgtcgac aggcctccta ggcggaccgc ttgcatgcac 180 gcgttcgcga agtactcacg tggctccggt gcccgtcagt gggcagagcg cacatcgccc 240 acagtccccg agaagttggg gggaggggtc ggcaattgaa ccggtgccta gagaaggtgg 300 cgcggggtaa actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg 360 ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc 420 gccagaacac gcgtaagggc gaattccagc acactggcgg ccgttactag agccatgcat 480 gtgagtctat gggacccttg atgttttctt tccccttctt ttctatggtt aagttcatgt 540 cataggaagg ggagaagtaa cagggtacac atattgacca aatcagggta attttgcatt 600 tgtaatttta aaaaatgctt tcttctttta atatactttt ttgtttatct tatttctaat 660 actttcccta atctctttct ttcagggcaa taatgataca atgtatcatg cctctttgca 720 ccattctaaa gaataacagt gataatttct gggttaaggc aatagcaata tttctgcata 780 taaatatttc tgcatataaa ttgtaactga tgtaagaggt ttcatattgc taatagcagc 840 tacaatccag ctaccattct gcttttattt tatggttggg ataaggctgg attattctga 900 gtccaagcta ggcccttttg ctaatcatgt tcatacctct tatcttcctc ccacagcacc 960 ggtacccgga gcagcatgtg gactctcggg cgccgcgcag tagccggcct cctggcgtca 1020 cccagcccag cccaggccca gaccctcacc cgggtcccgc ggccggcaga gttggcccca 1080 ctctgcggcc gccgtggcct gcgcaccgac atcgatgcga cctgcacgcc ccgccgcgca 1140 agttcgaacc aacgtggcct caaccagatt tggaatgtca aaaagcagag tgtctatttg 1200 atgaatttga ggaaatctgg aactttgggc cacccaggct ctctagatga gaccacctat 1260 gaaagactag cagaggaaac gctggactct ttagcagagt tttttgaaga ccttgcagac 1320 aagccataca cgtttgagga ctatgatgtc tcctttggga gtggtgtctt aactgtcaaa 1380 ctgggtggag atctaggaac ctatgtgatc aacaagcaga cgccaaacaa gcaaatctgg 1440 ctatcttctc catccagtgg acctaagcgt tatgactgga ctgggaaaaa ctgggtgtac 1500 tcccacgacg gcgtgtccct ccatgagctg ctggccgcag agctcactaa agccttaaaa 1560 accaaactgg acttgtcttc cttggcctat tccggaaaag atgcttgatt ctaggatccg 1620 actgcaggta ggtttaaaca agcttggtac cgtgattaat cttcgaatga ctgacctgtg 1680 ccttctagtt gccagccatc tgttgtttgc ccctcccccg tgccttcctt gaccctggaa 1740 ggtgccactc ccactgtcct ttcctaataa aatgaggaaa ttgcatcgca ttgtctgagt 1800 aggtgtcatt ctattctggg gggtggggtg gggcaggaca gcaaggggga ggattgggaa 1860 gacaatagca ggcatgctgg ggatgcggtg ggctctatgg agatctgtgt gttggttttt 1920 tgtgtgcgta cggagctacc aggtctcgag ccatgggcgc gccatcgatg actagtccac 1980 tccctctctg cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg cccgacgccc 2040 gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc agagaggga 2089 <210> 30 <211> 1998 <212> ADN <213> Secuencia artificial <220> <223> Casete de transferencia de AAV <400> 30 cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc 60 gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca 120 actccatcac taggggttcc ttgcgtcgac aggcctccta ggcggaccgc ttgcatgcac 180 gcgttcgcga agtactcacg tggctccggt gcccgtcagt gggcagagcg cacatcgccc 240 acagtccccg agaagttggg gggaggggtc ggcaattgaa ccggtgccta gagaaggtgg 300 cgcggggtaa actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg 360 ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc 420 gccagaacac gcgtaagggc gaattccagc acactggcgg ccgttactag agccatgcat 480 gtaagtatca aggttacaag acaggtttaa ggagaccaat agaaactggg cttgtcgaga 540 cagagaagac tcttgcgttt ctgataggca cctattggtc ttactgacat ccactttgcc 600 tttctctcca cagcaccggt acccggagca gcatgtggac tctcgggcgc cgcgcagtag 660 ccggcctcct ggcgtcaccc agcccagccc aggcccagac cctcacccgg gtcccgcggc 720 cggcagagtt ggccccactc tgcggccgcc gtggcctgcg caccgacatc gatgcgacct 780 gcacgccccg ccgcgcaagt tcgaaccaac gtggcctcaa ccagatttgg aatgtcaaaa 840 agcagagtgt ctatttgatg aatttgagga aatctggaac tttgggccac ccaggctctc 900 tagatgagac cacctatgaa agactagcag aggaaacgct ggactcttta gcagagtttt 960 ttgaagacct tgcagacaag ccatacacgt ttgaggacta tgatgtctcc tttgggagtg 1020 gtgtcttaac tgtcaaactg ggtggagatc taggaaccta tgtgatcaac aagcagacgc 1080 caaacaagca aatctggcta tcttctccat ccagtggacc taagcgttat gactggactg 1140 ggaaaaactg ggtgtactcc cacgacggcg tgtccctcca tgagctgctg gccgcagagc 1200 tcactaaagc cttaaaaacc aaactggact tgtcttcctt ggcctattcc ggaaaagatg 1260 cttgattcta ggatccgact gcaggtaggt ttaaacaagc ttggtaccgt gattaatctt 1320 cgaatgactg acgggtggca tccctgtgac ccctccccag tgcctctcct ggccctggaa 1380 gttgccactc cagtgcccac cagccttgtc ctaataaaat taagttgcat cattttgtct 1440 gactaggtgt ccttctataa tattatgggg tggagggggg tggtatggag caaggggcaa 1500 gttgggaaga caacctgtag ggcctgcggg gtctattggg aaccaagctg gagtgcagtg 1560 gcacaatctt ggctcactgc aatctccgcc tcctgggttc aagcgattct cctgcctcag 1620 cctcccgagt tgttgggatt ccaggcatgc atgaccaggc tcagctaatt tttgtttttt 1680 tggtagagac ggggtttcac catattggcc aggctggtct ccaactccta atctcaggtg 1740 atctacccac cttggcctcc caaattgctg ggattacagg cgtgaaccac tgctcccttc 1800 cctgtcctta gatctgtgtg ttggtttttt gtgtgcgtac ggagctacca ggtctcgagc 1860 catgggcgcg ccatcgatga ctagtccact ccctctctgc gcgctcgctc gctcactgag 1920 gccgggcgac caaaggtcgc ccgacgcccg ggctttgccc gggcggcctc agtgagcgag 1980 cgagcgcgca gagaggga 1998 <210> 31 <211> 2133 <212> ADN <213> Secuencia artificial <220> <223> Casete de transferencia de AAV <400> 31 cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc 60 gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca 120 actccatcac taggggttcc ttgcgtcgac aggcctccta ggcggaccgc ttgcatgcac 180 gcgttcgcga agtactcacg tgcgttacat aacttacggt aaatggcccg cctggctgac 240 cgcccaacga cccccgccca ttgacgtcaa tagtaacgcc aatagggact ttccattgac 300 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 360 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattgtgccc 420 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 480 ttaccatggt cgaggtgagc cccacgttct gcttcactct ccccatctcc cccccctccc 540 cacccccaat tttgtattta tttatttttt aattattttg tgcagcgatg ggggcggggg 600 gggggggggg gcgcgcgcca ggcggggcgg ggcggggcga ggggcggggc ggggcgaggc 660 ggagaggtgc ggcggcagcc aatcagagcg gcgcgctccg aaagtttcct tttatggcga 720 ggcggcggcg gcggcggccc tataaaaagc gaagcgcgcg gcgggcggga gtcgctgcga 780 cgctgccttc gccccgtgcc ccgctccgcc gccgcctcgc gccgcccgcc ccggctctga 840 ctgaccgcgt tactcccaca ggtgagcggg cgggacggcc cttctcctcc gggctgtaat 900 tagctgagca agaggtaagg gtttaaggga tggttggttg gtggggtatt aatgtttaat 960 tacctggagc acctgcctga aatcactttt tttcaggttg gaccggtacc cggagcagca 1020 tgtggactct cgggcgccgc gcagtagccg gcctcctggc gtcacccagc ccagcccagg 1080 cccagaccct cacccgggtc ccgcggccgg cagagttggc cccactctgc ggccgccgtg 1140 gcctgcgcac cgacatcgat gcgacctgca cgccccgccg cgcaagttcg aaccaacgtg 1200 gcctcaacca gatttggaat gtcaaaaagc agagtgtcta tttgatgaat ttgaggaaat 1260 ctggaacttt gggccaccca ggctctctag atgagaccac ctatgaaaga ctagcagagg 1320 aaacgctgga ctctttagca gagttttttg aagaccttgc agacaagcca tacacgtttg 1380 aggactatga tgtctccttt gggagtggtg tcttaactgt caaactgggt ggagatctag 1440 gaacctatgt gatcaacaag cagacgccaa acaagcaaat ctggctatct tctccatcca 1500 gtggacctaa gcgttatgac tggactggga aaaactgggt gtactcccac gacggcgtgt 1560 ccctccatga gctgctggcc gcagagctca ctaaagcctt aaaaaccaaa ctggacttgt 1620 cttccttggc ctattccgga aaagatgctt gattctagga tccgactgca ggtaggttta 1680 aacaagcttg gtaccgtgat taatcttcga atgactgacc tgtgccttct agttgccagc 1740 catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc actcccactg 1800 tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt cattctattc 1860 tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat agcaggcatg 1920 ctggggatgc ggtgggctct atggagatct gtgtgttggt tttttgtgtg cgtacggagc 1980 taccaggtct cgagccatgg gcgcgccatc gatgactagt ccactccctc tctgcgcgct 2040 cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg 2100 gcctcagtga gcgagcgagc gcgcagagag gga 2133 <210> 32 <211> 2077 <212> ADN <213> Secuencia artificial <220> <223> Casete de transferencia de AAV <400> 32 cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc 60 gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca 120 actccatcac taggggttcc ttgcgtcgac aggcctccta ggcggaccgc ttgcatgcac 180 gcgttcgcga agtactcacg tggctccggt gcccgtcagt gggcagagcg cacatcgccc 240 acagtccccg agaagttggg gggaggggtc ggcaattgaa ccggtgccta gagaaggtgg 300 cgcggggtaa actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg 360 ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc 420 gccagaacac gcgtaagggc gaattccagc acactggcgg ccgttactag agccatgcat 480 agtgaaccgt cagatcgcca tccagcctcc ggactctagt gatcaggtac tagaggaact 540 gaaaaaccag aaagttcatg taagtatcaa ggttacaaga caggtttaag gagaccaata 600 gaaactgggc ttgtcgagac agagaagact cttgcgtttc tgataggcac ctattggtct 660 tactgacatc cactttgcct ttctctccac agcaccggta cccggagcag catgtggact 720 ctcgggcgcc gcgcagtagc cggcctcctg gcgtcaccca gcccagccca ggcccagacc 780 ctcacccggg tcccgcggcc ggcagagttg gccccactct gcggccgccg tggcctgcgc 840 accgacatcg atgcgacctg cacgccccgc cgcgcaagtt cgaaccaacg tggcctcaac 900 cagatttgga atgtcaaaaa gcagagtgtc tatttgatga atttgaggaa atctggaact 960 ttgggccacc caggctctct agatgagacc acctatgaaa gactagcaga ggaaacgctg 1020 gactctttag cagagttttt tgaagacctt gcagacaagc catacacgtt tgaggactat 1080 gatgtctcct ttgggagtgg tgtcttaact gtcaaactgg gtggagatct aggaacctat 1140 gtgatcaaca agcagacgcc aaacaagcaa atctggctat cttctccatc cagtggacct 1200 aagcgttatg actggactgg gaaaaactgg gtgtactccc acgacggcgt gtccctccat 1260 gagctgctgg ccgcagagct cactaaagcc ttaaaaacca aactggactt gtcttccttg 1320 gcctattccg gaaaagatgc ttgattctag gatccgactg caggtaggtt taaacaagct 1380 tggtaccgtg attaatcttc gaatgactga cgggtggcat ccctgtgacc cctccccagt 1440 gcctctcctg gccctggaag ttgccactcc agtgcccacc agccttgtcc taataaaatt 1500 aagttgcatc attttgtctg actaggtgtc cttctataat attatggggt ggaggggggt 1560 ggtatggagc aaggggcaag ttgggaagac aacctgtagg gcctgcgggg tctattggga 1620 accaagctgg agtgcagtgg cacaatcttg gctcactgca atctccgcct cctgggttca 1680 agcgattctc ctgcctcagc ctcccgagtt gttgggattc caggcatgca tgaccaggct 1740 cagctaattt ttgttttttt ggtagagacg gggtttcacc atattggcca ggctggtctc 1800 caactcctaa tctcaggtga tctacccacc ttggcctccc aaattgctgg gattacaggc 1860 gtgaaccact gctcccttcc ctgtccttag atctgtgtgt tggttttttg tgtgcgtacg 1920 gagctaccag gtctcgagcc atgggcgcgc catcgatgac tagtccactc cctctctgcg 1980 cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg 2040 ggcggcctca gtgagcgagc gagcgcgcag agaggga 2077 <210> 33 <211> 2246 <212> ADN <213> Secuencia artificial <220> <223> Casete de transferencia de AAV <400> 33 cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc 60 gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca 120 actccatcac taggggttcc ttgcgtcgac aggcctccta ggcggaccgc ttgcatgcac 180 gcgttcgcga agtactcacg tggctccggt gcccgtcagt gggcagagcg cacatcgccc 240 acagtccccg agaagttggg gggaggggtc ggcaattgaa ccggtgccta gagaaggtgg 300 cgcggggtaa actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg 360 ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc 420 gccagaacac gcgtaagggc gaattccagc acactggcgg ccgttactag agccatgcat 480 agtgaaccgt cagatcgcca tccagcctcc ggactctagt gatcaggtac tagaggaact 540 gaaaaaccag aaagttaact ggtgagtcta tgggaccctt gatgttttct ttccccttct 600 tttctatggt taagttcatg tcataggaag gggagaagta acagggtaca catattgacc 660 aaatcagggt aattttgcat ttgtaatttt aaaaaatgct ttcttctttt aatatacttt 720 tttgtttatc ttatttctaa tactttccct aatctctttc tttcagggca ataatgatac 780 aatgtatcat gcctctttgc accattctaa agaataacag tgataatttc tgggttaagg 840 caatagcaat atttctgcat ataaatattt ctgcatataa attgtaactg atgtaagagg 900 tttcatattg ctaatagcag ctacaatcca gctaccattc tgcttttatt ttatggttgg 960 gataaggctg gattattctg agtccaagct aggccctttt gctaatcatg ttcatacctc 1020 ttatcttcct cccacagtac gtagcggccg cgggcccata tggcccagat ctgctagcac 1080 tagtggcgcc gtgaattcac cgcgggcccg atccaccggt acccggagca gcatgtggac 1140 tctcgggcgc cgcgcagtag ccggcctcct ggcgtcaccc agcccagccc aggcccagac 1200 cctcacccgg gtcccgcggc cggcagagtt ggccccactc tgcggccgcc gtggcctgcg 1260 caccgacatc gatgcgacct gcacgccccg ccgcgcaagt tcgaaccaac gtggcctcaa 1320 ccagatttgg aatgtcaaaa agcagagtgt ctatttgatg aatttgagga aatctggaac 1380 tttgggccac ccaggctctc tagatgagac cacctatgaa agactagcag aggaaacgct 1440 ggactcttta gcagagtttt ttgaagacct tgcagacaag ccatacacgt ttgaggacta 1500 tgatgtctcc tttgggagtg gtgtcttaac tgtcaaactg ggtggagatc taggaaccta 1560 tgtgatcaac aagcagacgc caaacaagca aatctggcta tcttctccat ccagtggacc 1620 taagcgttat gactggactg ggaaaaactg ggtgtactcc cacgacggcg tgtccctcca 1680 tgagctgctg gccgcagagc tcactaaagc cttaaaaacc aaactggact tgtcttcctt 1740 ggcctattcc ggaaaagatg cttgattcta ggatccgact gcaggtaggt ttaaacaagc 1800 ttggtaccgt gattaatctt cgaatgactg acctgtgcct tctagttgcc agccatctgt 1860 tgtttgcccc tcccccgtgc cttccttgac cctggaaggt gccactccca ctgtcctttc 1920 ctaataaaat gaggaaattg catcgcattg tctgagtagg tgtcattcta ttctgggggg 1980 tggggtgggg caggacagca agggggagga ttgggaagac aatagcaggc atgctgggga 2040 tgcggtgggc tctatggaga tctgtgtgtt ggttttttgt gtgcgtacgg agctaccagg 2100 tctcgagcca tgggcgcgcc atcgatgact agtccactcc ctctctgcgc gctcgctcgc 2160 tcactgaggc cgggcgacca aaggtcgccc gacgcccggg ctttgcccgg gcggcctcag 2220 tgagcgagcg agcgcgcaga gaggga 2246 <210> 34 <211> 1914 <212> ADN <213> Secuencia artificial <220> <223> Casete de transferencia de AAV <400> 34 cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc 60 gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca 120 actccatcac taggggttcc ttgcgtcgac cggctggggc tgagggtgag ggtcccgttt 180 ccccaaaggc ctagcctggg gttccagcca caagccctac cgggcagcgc ccggccccgc 240 ccctccaggc ctggcactcg tcctcaacca agatggcgcg gatggcttca ggcgcatcac 300 gacaccggcg cgtcacgcga cccgccctac gggcacctcc cgcgcttttc ttagcgccgc 360 agacggtggc cgagcggggg accgggaagc atgcatgtaa gtatcaaggt tacaagacag 420 gtttaaggag accaatagaa actgggcttg tcgagacaga gaagactctt gcgtttctga 480 taggcaccta ttggtcttac tgacatccac tttgcctttc tctccacagc accggtaccc 540 ggagcagcat gtggactctc gggcgccgcg cagtagccgg cctcctggcg tcacccagcc 600 cagcccaggc ccagaccctc acccgggtcc cgcggccggc agagttggcc ccactctgcg 660 gccgccgtgg cctgcgcacc gacatcgatg cgacctgcac gccccgccgc gcaagttcga 720 accaacgtgg cctcaaccag atttggaatg tcaaaaagca gagtgtctat ttgatgaatt 780 tgaggaaatc tggaactttg ggccacccag gctctctaga tgagaccacc tatgaaagac 840 tagcagagga aacgctggac tctttagcag agttttttga agaccttgca gacaagccat 900 acacgtttga ggactatgat gtctcctttg ggagtggtgt cttaactgtc aaactgggtg 960 gagatctagg aacctatgtg atcaacaagc agacgccaaa caagcaaatc tggctatctt 1020 ctccatccag tggacctaag cgttatgact ggactgggaa aaactgggtg tactcccacg 1080 acggcgtgtc cctccatgag ctgctggccg cagagctcac taaagcctta aaaaccaaac 1140 tggacttgtc ttccttggcc tattccggaa aagatgcttg attctaggat ccgactgcag 1200 gtaggtttaa acaagcttgg taccgtgatt aatcttcgaa tgactgacgg gtggcatccc 1260 tgtgacccct ccccagtgcc tctcctggcc ctggaagttg ccactccagt gcccaccagc 1320 cttgtcctaa taaaattaag ttgcatcatt ttgtctgact aggtgtcctt ctataatatt 1380 atggggtgga ggggggtggt atggagcaag gggcaagttg ggaagacaac ctgtagggcc 1440 tgcggggtct attgggaacc aagctggagt gcagtggcac aatcttggct cactgcaatc 1500 tccgcctcct gggttcaagc gattctcctg cctcagcctc ccgagttgtt gggattccag 1560 gcatgcatga ccaggctcag ctaatttttg tttttttggt agagacgggg tttcaccata 1620 ttggccaggc tggtctccaa ctcctaatct caggtgatct acccaccttg gcctcccaaa 1680 ttgctgggat tacaggcgtg aaccactgct cccttccctg tccttagatc tgtgtgttgg 1740 ttttttgtgt gcgtacggag ctaccaggtc tcgagccatg ggcgcgccat cgatgactag 1800 tccactccct ctctgcgcgc tcgctcgctc actgaggccg ggcgaccaaa ggtcgcccga 1860 cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag cgcgcagaga ggga 1914 <210> 35 <211> 2083 <212> ADN <213> Secuencia artificial <220> <223> Casete de transferencia de AAV <400> 35 cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc 60 gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca 120 actccatcac taggggttcc ttgcgtcgac cggctggggc tgagggtgag ggtcccgttt 180 ccccaaaggc ctagcctggg gttccagcca caagccctac cgggcagcgc ccggccccgc 240 ccctccaggc ctggcactcg tcctcaacca agatggcgcg gatggcttca ggcgcatcac 300 gacaccggcg cgtcacgcga cccgccctac gggcacctcc cgcgcttttc ttagcgccgc 360 agacggtggc cgagcggggg accgggaagc atgaactggt gagtctatgg gacccttgat 420 gttttctttc cccttctttt ctatggttaa gttcatgtca taggaagggg agaagtaaca 480 gggtacacat attgaccaaa tcagggtaat tttgcatttg taattttaaa aaatgctttc 540 ttcttttaat atactttttt gtttatctta tttctaatac tttccctaat ctctttcttt 600 cagggcaata atgatacaat gtatcatgcc tctttgcacc attctaaaga ataacagtga 660 taatttctgg gttaaggcaa tagcaatatt tctgcatata aatatttctg catataaatt 720 gtaactgatg taagaggttt catattgcta atagcagcta caatccagct accattctgc 780 ttttatttta tggttgggat aaggctggat tattctgagt ccaagctagg cccttttgct 840 aatcatgttc atacctctta tcttcctccc acagtacgta gcggccgcgg gcccatatgg 900 cccagatctg ctagcactag tggcgccgtg aattcaccgc gggcccgatc caccggtacc 960 cggagcagca tgtggactct cgggcgccgc gcagtagccg gcctcctggc gtcacccagc 1020 ccagcccagg cccagaccct cacccgggtc ccgcggccgg cagagttggc cccactctgc 1080 ggccgccgtg gcctgcgcac cgacatcgat gcgacctgca cgccccgccg cgcaagttcg 1140 aaccaacgtg gcctcaacca gatttggaat gtcaaaaagc agagtgtcta tttgatgaat 1200 ttgaggaaat ctggaacttt gggccaccca ggctctctag atgagaccac ctatgaaaga 1260 ctagcagagg aaacgctgga ctctttagca gagttttttg aagaccttgc agacaagcca 1320 tacacgtttg aggactatga tgtctccttt gggagtggtg tcttaactgt caaactgggt 1380 ggagatctag gaacctatgt gatcaacaag cagacgccaa acaagcaaat ctggctatct 1440 tctccatcca gtggacctaa gcgttatgac tggactggga aaaactgggt gtactcccac 1500 gacggcgtgt ccctccatga gctgctggcc gcagagctca ctaaagcctt aaaaaccaaa 1560 ctggacttgt cttccttggc ctattccgga aaagatgctt gattctagga tccgactgca 1620 ggtaggttta aacaagcttg gtaccgtgat taatcttcga atgactgacc tgtgccttct 1680 agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc 1740 actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt 1800 cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat 1860 agcaggcatg ctggggatgc ggtgggctct atggagatct gtgtgttggt tttttgtgtg 1920 cgtacggagc taccaggtct cgagccatgg gcgcgccatc gatgactagt ccactccctc 1980 tctgcgcgct cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt 2040 tgcccgggcg gcctcagtga gcgagcgagc gcgcagagag gga 2083 <210> 36 <211> 1879 <212> ADN <213> Secuencia artificial <220> <223> Casete de transferencia de AAV <400> 36 cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc 60 gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca 120 actccatcac taggggttcc ttgcgtcgac cggctggggc tgagggtgag ggtcccgttt 180 ccccaaaggc ctagcctggg gttccagcca caagccctac cgggcagcgc ccggccccgc 240 ccctccaggc ctggcactcg tcctcaacca agatggcgcg gatggcttca ggcgcatcac 300 gacaccggcg cgtcacgcga cccgccctac gggcacctcc cgcgcttttc ttagcgccgc 360 agacggtggc cgagcggggg accgggaagc atgcatgtaa gtttagtctt tttgtctttt 420 atttcaggtc ccggatccgg tggtggtgca aatcaaagaa ctgctcctca gtggatgttg 480 cctttacttc tagcaccggt acccggagca gcatgtggac tctcgggcgc cgcgcagtag 540 ccggcctcct ggcgtcaccc agcccagccc aggcccagac cctcacccgg gtcccgcggc 600 cggcagagtt ggccccactc tgcggccgcc gtggcctgcg caccgacatc gatgcgacct 660 gcacgccccg ccgcgcaagt tcgaaccaac gtggcctcaa ccagatttgg aatgtcaaaa 720 agcagagtgt ctatttgatg aatttgagga aatctggaac tttgggccac ccaggctctc 780 tagatgagac cacctatgaa agactagcag aggaaacgct ggactcttta gcagagtttt 840 ttgaagacct tgcagacaag ccatacacgt ttgaggacta tgatgtctcc tttgggagtg 900 gtgtcttaac tgtcaaactg ggtggagatc taggaaccta tgtgatcaac aagcagacgc 960 caaacaagca aatctggcta tcttctccat ccagtggacc taagcgttat gactggactg 1020 ggaaaaactg ggtgtactcc cacgacggcg tgtccctcca tgagctgctg gccgcagagc 1080 tcactaaagc cttaaaaacc aaactggact tgtcttcctt ggcctattcc ggaaaagatg 1140 cttgattcta ggatccgact gcaggtaggt ttaaacaagc ttggtaccgt gattaatctt 1200 cgaatgactg acgggtggca tccctgtgac ccctccccag tgcctctcct ggccctggaa 1260 gttgccactc cagtgcccac cagccttgtc ctaataaaat taagttgcat cattttgtct 1320 gactaggtgt ccttctataa tattatgggg tggagggggg tggtatggag caaggggcaa 1380 gttgggaaga caacctgtag ggcctgcggg gtctattggg aaccaagctg gagtgcagtg 1440 gcacaatctt ggctcactgc aatctccgcc tcctgggttc aagcgattct cctgcctcag 1500 cctcccgagt tgttgggatt ccaggcatgc atgaccaggc tcagctaatt tttgtttttt 1560 tggtagagac ggggtttcac catattggcc aggctggtct ccaactccta atctcaggtg 1620 atctacccac cttggcctcc caaattgctg ggattacagg cgtgaaccac tgctcccttc 1680 cctgtcctta gatctgtgtg ttggtttttt gtgtgcgtac ggagctacca ggtctcgagc 1740 catggggcgc gccatcgatg actagtccac tccctctctg cgcgctcgct cgctcactga 1800 ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc cgggcggcct cagtgagcga 1860 gcgagcgcgc agagaggga 1879 <210> 37 <211> 2018 <212> ADN <213> Secuencia artificial <220> <223> Casete de transferencia de AAV <400> 37 cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc 60 gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca 120 actccatcac taggggttcc ttgcgtcgac attcctgctg ggaaaagcaa gtggaggtgc 180 tccttgaaga aacaggggga tcccaccgat ctcaggggtt ctgttctggc ctgcggccct 240 ggatcgtcca gcctgggtcg gggtggggag cagacctcgc ccttatcggc tggggctgag 300 ggtgagggtc ccgtttcccc aaaggcctag cctggggttc cagccacaag ccctaccggg 360 cagcgcccgg ccccgcccct ccaggcctgg cactcgtcct caaccaagat ggcgcggatg 420 gcttcaggcg catcacgaca ccggcgcgtc acgcgacccg ccctacgggc acctcccgcg 480 cttttcttag cgccgcagac ggtggtcgag cgggggaccg ggaagcttaa tgcatgtaag 540 tttagtcttt ttgtctttta tttcaggtcc cggatccggt ggtggtgcaa atcaaagaac 600 tgctcctcag tggatgttgc ctttacttct agcaccggta cccggagcag catgtggact 660 ctcgggcgcc gcgcagtagc cggcctcctg gcgtcaccca gcccagccca ggcccagacc 720 ctcacccggg tcccgcggcc ggcagagttg gccccactct gcggccgccg tggcctgcgc 780 accgacatcg atgcgacctg cacgccccgc cgcgcaagtt cgaaccaacg tggcctcaac 840 cagatttgga atgtcaaaaa gcagagtgtc tatttgatga atttgaggaa atctggaact 900 ttgggccacc caggctctct agatgagacc acctatgaaa gactagcaga ggaaacgctg 960 gactctttag cagagttttt tgaagacctt gcagacaagc catacacgtt tgaggactat 1020 gatgtctcct ttgggagtgg tgtcttaact gtcaaactgg gtggagatct aggaacctat 1080 gtgatcaaca agcagacgcc aaacaagcaa atctggctat cttctccatc cagtggacct 1140 aagcgttatg actggactgg gaaaaactgg gtgtactccc acgacggcgt gtccctccat 1200 gagctgctgg ccgcagagct cactaaagcc ttaaaaacca aactggactt gtcttccttg 1260 gcctattccg gaaaagatgc ttgattctag gatccgactg caggtaggtt taaacaagct 1320 tggtaccgtg attaatcttc gaatgactga cgggtggcat ccctgtgacc cctccccagt 1380 gcctctcctg gccctggaag ttgccactcc agtgcccacc agccttgtcc taataaaatt 1440 aagttgcatc attttgtctg actaggtgtc cttctataat attatggggt ggaggggggt 1500 ggtatggagc aaggggcaag ttgggaagac aacctgtagg gcctgcgggg tctattggga 1560 accaagctgg agtgcagtgg cacaatcttg gctcactgca atctccgcct cctgggttca 1620 agcgattctc ctgcctcagc ctcccgagtt gttgggattc caggcatgca tgaccaggct 1680 cagctaattt ttgttttttt ggtagagacg gggtttcacc atattggcca ggctggtctc 1740 caactcctaa tctcaggtga tctacccacc ttggcctccc aaattgctgg gattacaggc 1800 gtgaaccact gctcccttcc ctgtccttag atctgtgtgt tggttttttg tgtgcgtacg 1860 gagctaccag gtctcgagcc atggggcgcg ccatcgatga ctagtccact ccctctctgc 1920 gcgctcgctc gctcactgag gccgggcgac caaaggtcgc ccgacgcccg ggctttgccc 1980 gggcggcctc agtgagcgag cgagcgcgca gagaggga 2018 <210> 38 <211> 2134 <212> ADN <213> Secuencia artificial <220> <223> Casete de transferencia de AAV <400> 38 cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc 60 gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca 120 actccatcac taggggttcc ttgcgtcgac aggcctccta ggcggaccgc ttgcatgcac 180 gcgttcgcga agtactcacg tgcgttacat aacttacggt aaatggcccg cctggctgac 240 cgcccaacga cccccgccca ttgacgtcaa tagtaacgcc aatagggact ttccattgac 300 gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata 360 tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattgtgccc 420 agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta 480 ttaccatggt cgaggtgagc cccacgttct gcttcactct ccccatctcc cccccctccc 540 cacccccaat tttgtattta tttatttttt aattattttg tgcagcgatg ggggcggggg 600 gggggggggg gcgcgcgcca ggcggggcgg ggcggggcga ggggcggggc ggggcgaggc 660 ggagaggtgc ggcggcagcc aatcagagcg gcgcgctccg aaagtttcct tttatggcga 720 ggcggcggcg gcggcggccc tataaaaagc gaagcgcgcg gcgggcggga gtcgctgcga 780 cgctgccttc gccccgtgcc ccgctccgcc gccgcctcgc gccgcccgcc ccggctctga 840 ctgaccgcgt tactcccaca ggtgagcggg cgggacggcc cttctcctcc gggctgtaat 900 tagctgagca agaggtaagg gtttaaggga tggttggttg gtggggtatt aatgtttaat 960 tacctggagc acctgcctga aatcactttt tttcaggttg gaccggtacc cacagccacc 1020 atgtggactc tcgggcgccg cgcagtagcc ggcctcctgg cgtcacccag cccagcccag 1080 gcccagaccc tcacccgggt cccgcggccg gcagagttgg ccccactctg cggccgccgt 1140 ggcctgcgca ccgacatcga tgcgacctgc acgccccgcc gcgcaagttc gaaccaacgt 1200 ggcctcaacc agatttggaa tgtcaaaaag cagagtgtct atttgatgaa tttgaggaaa 1260 tctggaactt tgggccaccc aggctctcta gatgagacca cctatgaaag actagcagag 1320 gaaacgctgg actctttagc agagtttttt gaagaccttg cagacaagcc atacacgttt 1380 gaggactatg atgtctcctt tgggagtggt gtcttaactg tcaaactggg tggagatcta 1440 ggaacctatg tgatcaacaa gcagacgcca aacaagcaaa tctggctatc ttctccatcc 1500 agtggaccta agcgttatga ctggactggg aaaaactggg tgtactccca cgacggcgtg 1560 tccctccatg agctgctggc cgcagagctc actaaagcct taaaaaccaa actggacttg 1620 tcttccttgg cctattccgg aaaagatgct tgattctagg atccgactgc aggtaggttt 1680 aaacaagctt ggtaccgtga ttaatcttcg aatgactgac ctgtgccttc tagttgccag 1740 ccatctgttg tttgcccctc ccccgtgcct tccttgaccc tggaaggtgc cactcccact 1800 gtcctttcct aataaaatga ggaaattgca tcgcattgtc tgagtaggtg tcattctatt 1860 ctggggggtg gggtggggca ggacagcaag ggggaggatt gggaagacaa tagcaggcat 1920 gctggggatg cggtgggctc tatggagatc tgtgtgttgg ttttttgtgt gcgtacggag 1980 ctaccaggtc tcgagccatg ggcgcgccat cgatgactag tccactccct ctctgcgcgc 2040 tcgctcgctc actgaggccg ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc 2100 ggcctcagtg agcgagcgag cgcgcagaga ggga 2134 <210> 39 <211> 2078 <212> ADN <213> Secuencia artificial <220> <223> Casete de transferencia de AAV <400> 39 cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc 60 gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca 120 actccatcac taggggttcc ttgcgtcgac aggcctccta ggcggaccgc ttgcatgcac 180 gcgttcgcga agtactcacg tggctccggt gcccgtcagt gggcagagcg cacatcgccc 240 acagtccccg agaagttggg gggaggggtc ggcaattgaa ccggtgccta gagaaggtgg 300 cgcggggtaa actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg 360 ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc 420 gccagaacac gcgtaagggc gaattccagc acactggcgg ccgttactag agccatgcat 480 agtgaaccgt cagatcgcca tccagcctcc ggactctagt gatcaggtac tagaggaact 540 gaaaaaccag aaagttcatg taagtatcaa ggttacaaga caggtttaag gagaccaata 600 gaaactgggc ttgtcgagac agagaagact cttgcgtttc tgataggcac ctattggtct 660 tactgacatc cactttgcct ttctctccac agcaccggta cccacagcca ccatgtggac 720 tctcgggcgc cgcgcagtag ccggcctcct ggcgtcaccc agcccagccc aggcccagac 780 cctcacccgg gtcccgcggc cggcagagtt ggccccactc tgcggccgcc gtggcctgcg 840 caccgacatc gatgcgacct gcacgccccg ccgcgcaagt tcgaaccaac gtggcctcaa 900 ccagatttgg aatgtcaaaa agcagagtgt ctatttgatg aatttgagga aatctggaac 960 tttgggccac ccaggctctc tagatgagac cacctatgaa agactagcag aggaaacgct 1020 ggactcttta gcagagtttt ttgaagacct tgcagacaag ccatacacgt ttgaggacta 1080 tgatgtctcc tttgggagtg gtgtcttaac tgtcaaactg ggtggagatc taggaaccta 1140 tgtgatcaac aagcagacgc caaacaagca aatctggcta tcttctccat ccagtggacc 1200 taagcgttat gactggactg ggaaaaactg ggtgtactcc cacgacggcg tgtccctcca 1260 tgagctgctg gccgcagagc tcactaaagc cttaaaaacc aaactggact tgtcttcctt 1320 ggcctattcc ggaaaagatg cttgattcta ggatccgact gcaggtaggt ttaaacaagc 1380 ttggtaccgt gattaatctt cgaatgactg acgggtggca tccctgtgac ccctccccag 1440 tgcctctcct ggccctggaa gttgccactc cagtgcccac cagccttgtc ctaataaaat 1500 taagttgcat cattttgtct gactaggtgt ccttctataa tattatgggg tggagggggg 1560 tggtatggag caaggggcaa gttgggaaga caacctgtag ggcctgcggg gtctattggg 1620 aaccaagctg gagtgcagtg gcacaatctt ggctcactgc aatctccgcc tcctgggttc 1680 aagcgattct cctgcctcag cctcccgagt tgttgggatt ccaggcatgc atgaccaggc 1740 tcagctaatt tttgtttttt tggtagagac ggggtttcac catattggcc aggctggtct 1800 ccaactccta atctcaggtg atctacccac cttggcctcc caaattgctg ggattacagg 1860 cgtgaaccac tgctcccttc cctgtcctta gatctgtgtg ttggtttttt gtgtgcgtac 1920 ggagctacca ggtctcgagc catgggcgcg ccatcgatga ctagtccact ccctctctgc 1980 gcgctcgctc gctcactgag gccgggcgac caaaggtcgc ccgacgcccg ggctttgccc 2040 gggcggcctc agtgagcgag cgagcgcgca gagaggga 2078 <210> 40 <211> 2247 <212> ADN <213> Secuencia artificial <220> <223> Casete de transferencia de AAV <400> 40 cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc 60 gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca 120 actccatcac taggggttcc ttgcgtcgac aggcctccta ggcggaccgc ttgcatgcac 180 gcgttcgcga agtactcacg tggctccggt gcccgtcagt gggcagagcg cacatcgccc 240 acagtccccg agaagttggg gggaggggtc ggcaattgaa ccggtgccta gagaaggtgg 300 cgcggggtaa actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg 360 ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc 420 gccagaacac gcgtaagggc gaattccagc acactggcgg ccgttactag agccatgcat 480 agtgaaccgt cagatcgcca tccagcctcc ggactctagt gatcaggtac tagaggaact 540 gaaaaaccag aaagttaact ggtgagtcta tgggaccctt gatgttttct ttccccttct 600 tttctatggt taagttcatg tcataggaag gggagaagta acagggtaca catattgacc 660 aaatcagggt aattttgcat ttgtaatttt aaaaaatgct ttcttctttt aatatacttt 720 tttgtttatc ttatttctaa tactttccct aatctctttc tttcagggca ataatgatac 780 aatgtatcat gcctctttgc accattctaa agaataacag tgataatttc tgggttaagg 840 caatagcaat atttctgcat ataaatattt ctgcatataa attgtaactg atgtaagagg 900 tttcatattg ctaatagcag ctacaatcca gctaccattc tgcttttatt ttatggttgg 960 gataaggctg gattattctg agtccaagct aggccctttt gctaatcatg ttcatacctc 1020 ttatcttcct cccacagtac gtagcggccg cgggcccata tggcccagat ctgctagcac 1080 tagtggcgcc gtgaattcac cgcgggcccg atccaccggt acccacagcc accatgtgga 1140 ctctcgggcg ccgcgcagta gccggcctcc tggcgtcacc cagcccagcc caggcccaga 1200 ccctcacccg ggtcccgcgg ccggcagagt tggccccact ctgcggccgc cgtggcctgc 1260 gcaccgacat cgatgcgacc tgcacgcccc gccgcgcaag ttcgaaccaa cgtggcctca 1320 accagatttg gaatgtcaaa aagcagagtg tctatttgat gaatttgagg aaatctggaa 1380 ctttgggcca cccaggctct ctagatgaga ccacctatga aagactagca gaggaaacgc 1440 tggactcttt agcagagttt tttgaagacc ttgcagacaa gccatacacg tttgaggact 1500 atgatgtctc ctttgggagt ggtgtcttaa ctgtcaaact gggtggagat ctaggaacct 1560 atgtgatcaa caagcagacg ccaaacaagc aaatctggct atcttctcca tccagtggac 1620 ctaagcgtta tgactggact gggaaaaact gggtgtactc ccacgacggc gtgtccctcc 1680 atgagctgct ggccgcagag ctcactaaag ccttaaaaac caaactggac ttgtcttcct 1740 tggcctattc cggaaaagat gcttgattct aggatccgac tgcaggtagg tttaaacaag 1800 cttggtaccg tgattaatct tcgaatgact gacctgtgcc ttctagttgc cagccatctg 1860 ttgtttgccc ctcccccgtg ccttccttga ccctggaagg tgccactccc actgtccttt 1920 cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct attctggggg 1980 gtggggtggg gcaggacagc aagggggagg attgggaaga caatagcagg catgctgggg 2040 atgcggtggg ctctatggag atctgtgtgt tggttttttg tgtgcgtacg gagctaccag 2100 gtctcgagcc atgggcgcgc catcgatgac tagtccactc cctctctgcg cgctcgctcg 2160 ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca 2220 gtgagcgagc gagcgcgcag agaggga 2247 <210> 41 <211> 1915 <212> ADN <213> Secuencia artificial <220> <223> Casete de transferencia de AAV <400> 41 cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc 60 gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca 120 actccatcac taggggttcc ttgcgtcgac cggctggggc tgagggtgag ggtcccgttt 180 ccccaaaggc ctagcctggg gttccagcca caagccctac cgggcagcgc ccggccccgc 240 ccctccaggc ctggcactcg tcctcaacca agatggcgcg gatggcttca ggcgcatcac 300 gacaccggcg cgtcacgcga cccgccctac gggcacctcc cgcgcttttc ttagcgccgc 360 agacggtggc cgagcggggg accgggaagc atgcatgtaa gtatcaaggt tacaagacag 420 gtttaaggag accaatagaa actgggcttg tcgagacaga gaagactctt gcgtttctga 480 taggcaccta ttggtcttac tgacatccac tttgcctttc tctccacagc accggtaccc 540 acagccacca tgtggactct cgggcgccgc gcagtagccg gcctcctggc gtcacccagc 600 ccagcccagg cccagaccct cacccgggtc ccgcggccgg cagagttggc cccactctgc 660 ggccgccgtg gcctgcgcac cgacatcgat gcgacctgca cgccccgccg cgcaagttcg 720 aaccaacgtg gcctcaacca gatttggaat gtcaaaaagc agagtgtcta tttgatgaat 780 ttgaggaaat ctggaacttt gggccaccca ggctctctag atgagaccac ctatgaaaga 840 ctagcagagg aaacgctgga ctctttagca gagttttttg aagaccttgc agacaagcca 900 tacacgtttg aggactatga tgtctccttt gggagtggtg tcttaactgt caaactgggt 960 ggagatctag gaacctatgt gatcaacaag cagacgccaa acaagcaaat ctggctatct 1020 tctccatcca gtggacctaa gcgttatgac tggactggga aaaactgggt gtactcccac 1080 gacggcgtgt ccctccatga gctgctggcc gcagagctca ctaaagcctt aaaaaccaaa 1140 ctggacttgt cttccttggc ctattccgga aaagatgctt gattctagga tccgactgca 1200 ggtaggttta aacaagcttg gtaccgtgat taatcttcga atgactgacg ggtggcatcc 1260 ctgtgacccc tccccagtgc ctctcctggc cctggaagtt gccactccag tgcccaccag 1320 ccttgtccta ataaaattaa gttgcatcat tttgtctgac taggtgtcct tctataatat 1380 tatggggtgg aggggggtgg tatggagcaa ggggcaagtt gggaagacaa cctgtagggc 1440 ctgcggggtc tattgggaac caagctggag tgcagtggca caatcttggc tcactgcaat 1500 ctccgcctcc tgggttcaag cgattctcct gcctcagcct cccgagttgt tgggattcca 1560 ggcatgcatg accaggctca gctaattttt gtttttttgg tagagacggg gtttcaccat 1620 attggccagg ctggtctcca actcctaatc tcaggtgatc tacccacctt ggcctcccaa 1680 attgctggga ttacaggcgt gaaccactgc tcccttccct gtccttagat ctgtgtgttg 1740 gttttttgtg tgcgtacgga gctaccaggt ctcgagccat gggcgcgcca tcgatgacta 1800 gtccactccc tctctgcgcg ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg 1860 acgcccgggc tttgcccggg cggcctcagt gagcgagcga gcgcgcagag aggga 1915 <210> 42 <211> 2084 <212> ADN <213> Secuencia artificial <220> <223> Casete de transferencia de AAV <400> 42 cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc 60 gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca 120 actccatcac taggggttcc ttgcgtcgac cggctggggc tgagggtgag ggtcccgttt 180 ccccaaaggc ctagcctggg gttccagcca caagccctac cgggcagcgc ccggccccgc 240 ccctccaggc ctggcactcg tcctcaacca agatggcgcg gatggcttca ggcgcatcac 300 gacaccggcg cgtcacgcga cccgccctac gggcacctcc cgcgcttttc ttagcgccgc 360 agacggtggc cgagcggggg accgggaagc atgaactggt gagtctatgg gacccttgat 420 gttttctttc cccttctttt ctatggttaa gttcatgtca taggaagggg agaagtaaca 480 gggtacacat attgaccaaa tcagggtaat tttgcatttg taattttaaa aaatgctttc 540 ttcttttaat atactttttt gtttatctta tttctaatac tttccctaat ctctttcttt 600 cagggcaata atgatacaat gtatcatgcc tctttgcacc attctaaaga ataacagtga 660 taatttctgg gttaaggcaa tagcaatatt tctgcatata aatatttctg catataaatt 720 gtaactgatg taagaggttt catattgcta atagcagcta caatccagct accattctgc 780 ttttatttta tggttgggat aaggctggat tattctgagt ccaagctagg cccttttgct 840 aatcatgttc atacctctta tcttcctccc acagtacgta gcggccgcgg gcccatatgg 900 cccagatctg ctagcactag tggcgccgtg aattcaccgc gggcccgatc caccggtacc 960 cacagccacc atgtggactc tcgggcgccg cgcagtagcc ggcctcctgg cgtcacccag 1020 cccagcccag gcccagaccc tcacccgggt cccgcggccg gcagagttgg ccccactctg 1080 cggccgccgt ggcctgcgca ccgacatcga tgcgacctgc acgccccgcc gcgcaagttc 1140 gaaccaacgt ggcctcaacc agatttggaa tgtcaaaaag cagagtgtct atttgatgaa 1200 tttgaggaaa tctggaactt tgggccaccc aggctctcta gatgagacca cctatgaaag 1260 actagcagag gaaacgctgg actctttagc agagtttttt gaagaccttg cagacaagcc 1320 atacacgttt gaggactatg atgtctcctt tgggagtggt gtcttaactg tcaaactggg 1380 tggagatcta ggaacctatg tgatcaacaa gcagacgcca aacaagcaaa tctggctatc 1440 ttctccatcc agtggaccta agcgttatga ctggactggg aaaaactggg tgtactccca 1500 cgacggcgtg tccctccatg agctgctggc cgcagagctc actaaagcct taaaaaccaa 1560 actggacttg tcttccttgg cctattccgg aaaagatgct tgattctagg atccgactgc 1620 aggtaggttt aaacaagctt ggtaccgtga ttaatcttcg aatgactgac ctgtgccttc 1680 tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc tggaaggtgc 1740 cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc tgagtaggtg 1800 tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt gggaagacaa 1860 tagcaggcat gctggggatg cggtgggctc tatggagatc tgtgtgttgg ttttttgtgt 1920 gcgtacggag ctaccaggtc tcgagccatg ggcgcgccat cgatgactag tccactccct 1980 ctctgcgcgc tcgctcgctc actgaggccg ggcgaccaaa ggtcgcccga cgcccgggct 2040 ttgcccgggc ggcctcagtg agcgagcgag cgcgcagaga ggga 2084 <210> 43 <211> 1880 <212> ADN <213> Secuencia artificial <220> <223> Casete de transferencia de AAV <400> 43 cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc 60 gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca 120 actccatcac taggggttcc ttgcgtcgac cggctggggc tgagggtgag ggtcccgttt 180 ccccaaaggc ctagcctggg gttccagcca caagccctac cgggcagcgc ccggccccgc 240 ccctccaggc ctggcactcg tcctcaacca agatggcgcg gatggcttca ggcgcatcac 300 gacaccggcg cgtcacgcga cccgccctac gggcacctcc cgcgcttttc ttagcgccgc 360 agacggtggc cgagcggggg accgggaagc atgcatgtaa gtttagtctt tttgtctttt 420 atttcaggtc ccggatccgg tggtggtgca aatcaaagaa ctgctcctca gtggatgttg 480 cctttacttc tagcaccggt acccacagcc accatgtgga ctctcgggcg ccgcgcagta 540 gccggcctcc tggcgtcacc cagcccagcc caggcccaga ccctcacccg ggtcccgcgg 600 ccggcagagt tggccccact ctgcggccgc cgtggcctgc gcaccgacat cgatgcgacc 660 tgcacgcccc gccgcgcaag ttcgaaccaa cgtggcctca accagatttg gaatgtcaaa 720 aagcagagtg tctatttgat gaatttgagg aaatctggaa ctttgggcca cccaggctct 780 ctagatgaga ccacctatga aagactagca gaggaaacgc tggactcttt agcagagttt 840 tttgaagacc ttgcagacaa gccatacacg tttgaggact atgatgtctc ctttgggagt 900 ggtgtcttaa ctgtcaaact gggtggagat ctaggaacct atgtgatcaa caagcagacg 960 ccaaacaagc aaatctggct atcttctcca tccagtggac ctaagcgtta tgactggact 1020 gggaaaaact gggtgtactc ccacgacggc gtgtccctcc atgagctgct ggccgcagag 1080 ctcactaaag ccttaaaaac caaactggac ttgtcttcct tggcctattc cggaaaagat 1140 gcttgattct aggatccgac tgcaggtagg tttaaacaag cttggtaccg tgattaatct 1200 tcgaatgact gacgggtggc atccctgtga cccctcccca gtgcctctcc tggccctgga 1260 agttgccact ccagtgccca ccagccttgt cctaataaaa ttaagttgca tcattttgtc 1320 tgactaggtg tccttctata atattatggg gtggaggggg gtggtatgga gcaaggggca 1380 agttgggaag acaacctgta gggcctgcgg ggtctattgg gaaccaagct ggagtgcagt 1440 ggcacaatct tggctcactg caatctccgc ctcctgggtt caagcgattc tcctgcctca 1500 gcctcccgag ttgttgggat tccaggcatg catgaccagg ctcagctaat ttttgttttt 1560 ttggtagaga cggggtttca ccatattggc caggctggtc tccaactcct aatctcaggt 1620 gatctaccca ccttggcctc ccaaattgct gggattacag gcgtgaacca ctgctccctt 1680 ccctgtcctt agatctgtgt gttggttttt tgtgtgcgta cggagctacc aggtctcgag 1740 ccatggggcg cgccatcgat gactagtcca ctccctctct gcgcgctcgc tcgctcactg 1800 aggccgggcg accaaaggtc gcccgacgcc cgggctttgc ccgggcggcc tcagtgagcg 1860 agcgagcgcg cagagaggga 1880 <210> 44 <211> 2019 <212> ADN <213> Secuencia artificial <220> <223> Casete de transferencia de AAV <400> 44 cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc 60 gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca 120 actccatcac taggggttcc ttgcgtcgac attcctgctg ggaaaagcaa gtggaggtgc 180 tccttgaaga aacaggggga tcccaccgat ctcaggggtt ctgttctggc ctgcggccct 240 ggatcgtcca gcctgggtcg gggtggggag cagacctcgc ccttatcggc tggggctgag 300 ggtgagggtc ccgtttcccc aaaggcctag cctggggttc cagccacaag ccctaccggg 360 cagcgcccgg ccccgcccct ccaggcctgg cactcgtcct caaccaagat ggcgcggatg 420 gcttcaggcg catcacgaca ccggcgcgtc acgcgacccg ccctacgggc acctcccgcg 480 cttttcttag cgccgcagac ggtggtcgag cgggggaccg ggaagcttaa tgcatgtaag 540 tttagtcttt ttgtctttta tttcaggtcc cggatccggt ggtggtgcaa atcaaagaac 600 tgctcctcag tggatgttgc ctttacttct agcaccggta cccacagcca ccatgtggac 660 tctcgggcgc cgcgcagtag ccggcctcct ggcgtcaccc agcccagccc aggcccagac 720 cctcacccgg gtcccgcggc cggcagagtt ggccccactc tgcggccgcc gtggcctgcg 780 caccgacatc gatgcgacct gcacgccccg ccgcgcaagt tcgaaccaac gtggcctcaa 840 ccagatttgg aatgtcaaaa agcagagtgt ctatttgatg aatttgagga aatctggaac 900 tttgggccac ccaggctctc tagatgagac cacctatgaa agactagcag aggaaacgct 960 ggactcttta gcagagtttt ttgaagacct tgcagacaag ccatacacgt ttgaggacta 1020 tgatgtctcc tttgggagtg gtgtcttaac tgtcaaactg ggtggagatc taggaaccta 1080 tgtgatcaac aagcagacgc caaacaagca aatctggcta tcttctccat ccagtggacc 1140 taagcgttat gactggactg ggaaaaactg ggtgtactcc cacgacggcg tgtccctcca 1200 tgagctgctg gccgcagagc tcactaaagc cttaaaaacc aaactggact tgtcttcctt 1260 ggcctattcc ggaaaagatg cttgattcta ggatccgact gcaggtaggt ttaaacaagc 1320 ttggtaccgt gattaatctt cgaatgactg acgggtggca tccctgtgac ccctccccag 1380 tgcctctcct ggccctggaa gttgccactc cagtgcccac cagccttgtc ctaataaaat 1440 taagttgcat cattttgtct gactaggtgt ccttctataa tattatgggg tggagggggg 1500 tggtatggag caaggggcaa gttgggaaga caacctgtag ggcctgcggg gtctattggg 1560 aaccaagctg gagtgcagtg gcacaatctt ggctcactgc aatctccgcc tcctgggttc 1620 aagcgattct cctgcctcag cctcccgagt tgttgggatt ccaggcatgc atgaccaggc 1680 tcagctaatt tttgtttttt tggtagagac ggggtttcac catattggcc aggctggtct 1740 ccaactccta atctcaggtg atctacccac cttggcctcc caaattgctg ggattacagg 1800 cgtgaaccac tgctcccttc cctgtcctta gatctgtgtg ttggtttttt gtgtgcgtac 1860 ggagctacca ggtctcgagc catggggcgc gccatcgatg actagtccac tccctctctg 1920 cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc 1980 cgggcggcct cagtgagcga gcgagcgcgc agagaggga 2019 <210> 45 <211> 3063 <212> ADN <213> Secuencia artificial <220> <223> Casete de transferencia de AAV <400> 45 cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc 60 gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca 120 actccatcac taggggttcc taacttgcat atgcatgcta aaatacagca tagcaaaact 180 ttaacctcca aatcaagcct ctacttgaat ccttttctga gggatgaata aggcataggc 240 atcaggggct gttgccaatg tgcattagct gtttgcagcc tcaccttctt tcatggagtt 300 taagatatag tgtattttcc caaggtttga actagctctt catttcttta tgttttaaat 360 gcactgacct cccacattcc ctttttagta aaatattcag aaataattta aatacatcat 420 tgcaatgaaa ataaatgttt tttattaggc agaatccaga tgctcaaggc ccttcataat 480 atcccccagt ttagtagttg gacttaggga acaaaggaac ctttaataga aattggacag 540 caagaaagcg agcagtactc agtggggggt tggggttgcg ccttttccaa ggcagccctg 600 ggtttgcgca gggacgcggc tgctctgggc gtggttccgg gaaacgcagc ggcgccgacc 660 ctgggtctcg cacattcttc acgtccgttc gcagcgtcac ccggatcttc gccgctaccc 720 ttgtgggccc cccggcgacg cttcctgctc cgcccctaag tcgggaaggt tccttgcggt 780 tcgcggcgtg ccggacgtga caaacggaag ccgcacgtct cactagtacc ctcgcagacg 840 gacagcgcca gggagcaatg gcagcgcgcc gaccgcgatg ggctgtggcc aatagcggct 900 gctcagcagg gcgcgccgag agcagcggcc gggaaggggc ggtgcgggag gcggggtgtg 960 gggcggtagt gtgggccctg ttcctgcccg cgcggtgttc cgcattctgc aagcctccgg 1020 agcgcacgtc ggcagtcggc tccctcgttg accgaatcac cgacctctct ccccaggtga 1080 gtctatggga cccttgatgt tttctttccc cttcttttct atggttaagt tcatgtcata 1140 ggaaggggag aagtaacagg gtacacatat tgaccaaatc agggtaattt tgcatttgta 1200 attttaaaaa atgctttctt cttttaatat acttttttgt ttatcttatt tctaatactt 1260 tccctaatct ctttctttca gggcaataat gatacaatgt atcatgcctc tttgcaccat 1320 tctaaagaat aacagtgata atttctgggt taaggcaata gcaatatttc tgcatataaa 1380 tatttctgca tataaattgt aactgatgta agaggtttca tattgctaat agcagctaca 1440 atccagctac cattctgctt ttattttatg gttgggataa ggctggatta ttctgagtcc 1500 aagctaggcc cttttgctaa tcatgttcat acctcttatc ttcctcccac agcatagcgg 1560 tacctaccca cagccaccat gtggactctc gggcgccgcg cagtagccgg cctcctggcg 1620 tcacccagcc cagcccaggc ccagaccctc acccgggtcc cgcggccggc agagttggcc 1680 ccactctgcg gccgccgtgg cctgcgcacc gacatcgatg cgacctgcac gccccgccgc 1740 gcaagttcga accaacgtgg cctcaaccag atttggaatg tcaaaaagca gagtgtctat 1800 ttgatgaatt tgaggaaatc tggaactttg ggccacccag gctctctaga tgagaccacc 1860 tatgaaagac tagcagagga aacgctggac tctttagcag agttttttga agaccttgca 1920 gacaagccat acacgtttga ggactatgat gtctcctttg ggagtggtgt cttaactgtc 1980 aaactgggtg gagatctagg aacctatgtg atcaacaagc agacgccaaa caagcaaatc 2040 tggctatctt ctccatccag tggacctaag cgttatgact ggactgggaa aaactgggtg 2100 tactcccacg acggcgtgtc cctccatgag ctgctggccg cagagctcac taaagcctta 2160 aaaaccaaac tggacttgtc ttccttggcc tattccggaa aagatgcttg attctaggat 2220 gggtggcatc cctgtgaccc ctccccagtg cctctcctgg ccctggaagt tgccactcca 2280 gtgcccacca gccttgtcct aataaaatta agttgcatca ttttgtctga ctaggtgtcc 2340 ttctataata ttatggggtg gaggggggtg gtatggagca aggggcaagt tgggaagaca 2400 acctgtaggg cctgcggggt ctattgggaa ccaagctgga gtgcagtggc acaatcttgg 2460 ctcactgcaa tctccgcctc ctgggttcaa gcgattctcc tgcctcagcc tcccgagttg 2520 ttgggattcc aggcatgcat gaccaggctc agctaatttt tgtttttttg gtagagacgg 2580 ggtttcacca tattggccag gctggtctcc aactcctaat ctcaggtgat ctacccacct 2640 tggcctccca aattgctggg attacaggcg tgaaccactg ctcccttccc tgtccttaga 2700 tctgtgtaat aaaggaaatt tattttcatt gcaatagtgt gttggaattt tttgtgtctc 2760 tcagttggtt gtaagtatca aggttacaag acaggtttaa ggagaccaat agaaactggg 2820 cttgtcgaga cagagaagac tcttgcgttt ctgataggca cctattggtc ttactgacat 2880 ccactttgcc tttctctcca cagttgtaag ctttaccaga tgaggaaccc ctagtgatgg 2940 agttggccac tccctctctg cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg 3000 cccgacgccc gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc agctgcctgc 3060 agg 3063 <210> 46 <211> 3699 <212> ADN <213> Secuencia artificial <220> <223> Casete de transferencia de AAV <400> 46 cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc 60 gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca 120 actccatcac taggggttcc taacttgcat atgcatgcag agacacagtt tttgctctgg 180 tgaattacat cttctttaaa ggcaaatggg agagaccctt tgaagtcaag gacacagagg 240 aagaggactt cctagtggac caggtgacca ccttgaaggt gcctatgtaa aagcatttag 300 gcatgtttaa catccagcac tgtaagaagc tgtccagctg ggtgctgctg taaaaatacc 360 tgggcaatgc caccaccatc ttcttcctgc ctgatgaggg gaaactacag cacctggaaa 420 atgaactcac ccactatatt atcaccaagt tcctggaaaa tgaagacaga aggtctgcca 480 gcttacattt acccaaactg tcaattactg gaacctatga tctgaagagc ttcctgggtc 540 aactgggcat cactaaggtc ttcagcaatg gggctgacct ctcctgggtc acagaggagg 600 cacccctgaa gctctccaag gccttgcata aggctgtgct gaccatcaat aagaaaggta 660 aaatacagca tagcaaaact ttaacctcca aatcaagcct ctacttgaat ccttttctga 720 gggatgaata aggcataggc atcaggggct gttgccaatg tgcattagct gtttgcagcc 780 tcaccttctt tcatggagtt taagatatag tgtattttcc caaggtttga actagctctt 840 catttcttta tgttttaaat gcactgacct cccacattcc ctttttagta aaatattcag 900 aaataattta aatacatcat tgcaatgaaa ataaatgttt tttattaggc agaatccaga 960 tgctcaaggc ccttcataat atcccccagt ttagtagttg gacttaggga acaaaggaac 1020 ctttaataga aattggacag caagaaagcg agcagtactc agtggtcgag gtgagcccca 1080 cgttctgctt cactctcccc atctcccccc cctccccacc cccaattttg tatttattta 1140 ttttttaatt attttgtgca gcgatggggg cggggggggg gggggggcgc gcgccaggcg 1200 gggcggggcg gggcgagggg cggggcgggg cgaggcggag aggtgcggcg gcagccaatc 1260 agagcggcgc gctccgaaag tttcctttta tggcgaggcg gcggcggcgg cggccctata 1320 aaaagcgaag cgcgcggcgg gcggtgagtc tatgggaccc ttgatgtttt ctttcccctt 1380 cttttctatg gttaagttca tgtcatagga aggggagaag taacagggta cacatattga 1440 ccaaatcagg gtaattttgc atttgtaatt ttaaaaaatg ctttcttctt ttaatatact 1500 tttttgttta tcttatttct aatactttcc ctaatctctt tctttcaggg caataatgat 1560 acaatgtatc atgcctcttt gcaccattct aaagaataac agtgataatt tctgggttaa 1620 ggcaatagca atatttctgc atataaatat ttctgcatat aaattgtaac tgatgtaaga 1680 ggtttcatat tgctaatagc agctacaatc cagctaccat tctgctttta ttttatggtt 1740 gggataaggc tggattattc tgagtccaag ctaggccctt ttgctaatca tgttcatacc 1800 tcttatcttc ctcccacagc atagcggtac ctacccacag ccaccatgtg gactctcggg 1860 cgccgcgcag tagccggcct cctggcgtca cccagcccag cccaggccca gaccctcacc 1920 cgggtcccgc ggccggcaga gttggcccca ctctgcggcc gccgtggcct gcgcaccgac 1980 atcgatgcga cctgcacgcc ccgccgcgca agttcgaacc aacgtggcct caaccagatt 2040 tggaatgtca aaaagcagag tgtctatttg atgaatttga ggaaatctgg aactttgggc 2100 cacccaggct ctctagatga gaccacctat gaaagactag cagaggaaac gctggactct 2160 ttagcagagt tttttgaaga ccttgcagac aagccataca cgtttgagga ctatgatgtc 2220 tcctttggga gtggtgtctt aactgtcaaa ctgggtggag atctaggaac ctatgtgatc 2280 aacaagcaga cgccaaacaa gcaaatctgg ctatcttctc catccagtgg acctaagcgt 2340 tatgactgga ctgggaaaaa ctgggtgtac tcccacgacg gcgtgtccct ccatgagctg 2400 ctggccgcag agctcactaa agccttaaaa accaaactgg acttgtcttc cttggcctat 2460 tccggaaaag atgcttgatt ctaggatggg tggcatccct gtgacccctc cccagtgcct 2520 ctcctggccc tggaagttgc cactccagtg cccaccagcc ttgtcctaat aaaattaagt 2580 tgcatcattt tgtctgacta ggtgtccttc tataatatta tggggtggag gggggtggta 2640 tggagcaagg ggcaagttgg gaagacaacc tgtagggcct gcggggtcta ttgggaacca 2700 agctggagtg cagtggcaca atcttggctc actgcaatct ccgcctcctg ggttcaagcg 2760 attctcctgc ctcagcctcc cgagttgttg ggattccagg catgcatgac caggctcagc 2820 taatttttgt ttttttggta gagacggggt ttcaccatat tggccaggct ggtctccaac 2880 tcctaatctc aggtgatcta cccaccttgg cctcccaaat tgctgggatt acaggcgtga 2940 accactgctc ccttccctgt ccttagatct gtgtaataaa ggaaatttat tttcattgca 3000 atagtgtgtt ggaatttttt gtgtctctca taagtttttg tatgaatatg caagaaggca 3060 tcctgattac tctgtcttgc tgctgctgag acttgccaag acctatgaaa ccactctaga 3120 gaagtgctgt gcctctgcag atcctcatga atgctatgcc aaagtgttca gtgaatttaa 3180 acctcttgtg gaagagcctc agaatttaat caaacaaaat tgtgagcttt ttgagcagct 3240 tggagagtac aaattccaga atgcactatt agttctttac accaagaaag taccccaagt 3300 gtcaactcca actcttgtag aggtctcaag aaacctagga aaagtgggca gcaaatgttg 3360 taaacatcct gaagcaaaaa gaatgccctg tgcagaagac tatctatcct tggtcctgaa 3420 ccagttatgt gtgttgcatg agaaaacacc agtaagtgac agagtcacca aatgctgcac 3480 agaatccttg gtgaacaggc aaccatgctt ttcagctctg gaagttgatg aagttggttt 3540 tgtaagcttt accagatgag gaacccctag tgatggagtt ggccactccc tctctgcgcg 3600 ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg 3660 cggcctcagt gagcgagcga gcgcgcagct gcctgcagg 3699 <210> 47 <211> 3648 <212> ADN <213> Secuencia artificial <220> <223> Casete de transferencia de AAV <400> 47 cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc 60 gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca 120 actccatcac taggggttcc taacttgcat atgcatgcag agacacagtt tttgctctgg 180 tgaattacat cttctttaaa ggcaaatggg agagaccctt tgaagtcaag gacacagagg 240 aagaggactt cctagtggac caggtgacca ccttgaaggt gcctatgtaa aagcatttag 300 gcatgtttaa catccagcac tgtaagaagc tgtccagctg ggtgctgctg taaaaatacc 360 tgggcaatgc caccaccatc ttcttcctgc ctgatgaggg gaaactacag cacctggaaa 420 atgaactcac ccactatatt atcaccaagt tcctggaaaa tgaagacaga aggtctgcca 480 gcttacattt acccaaactg tcaattactg gaacctatga tctgaagagc ttcctgggtc 540 aactgggcat cactaaggtc ttcagcaatg gggctgacct ctcctgggtc acagaggagg 600 cacccctgaa gctctccaag gccttgcata aggctgtgct gaccatcaat aagaaaggta 660 aaatacagca tagcaaaact ttaacctcca aatcaagcct ctacttgaat ccttttctga 720 gggatgaata aggcataggc atcaggggct gttgccaatg tgcattagct gtttgcagcc 780 tcaccttctt tcatggagtt taagatatag tgtattttcc caaggtttga actagctctt 840 catttcttta tgttttaaat gcactgacct cccacattcc ctttttagta aaatattcag 900 aaataattta aatacatcat tgcaatgaaa ataaatgttt tttattaggc agaatccaga 960 tgctcaaggc ccttcataat atcccccagt ttagtagttg gacttaggga acaaaggaac 1020 ctttaataga aattggacag caagaaagcg agcagtactc agtgggcccg tcagtgggca 1080 gagcgcacat cgcccacagt ccccgagaag ttggggggag gggtcggcaa ttgaaccggt 1140 gcctagagaa ggtggcgcgg ggtaaactgg gaaagtgatg tcgtgtactg gctccgcctt 1200 tttcccgagg gtgggggaga accgtatata agtgcagtag tcgccgtgaa cgttcttttt 1260 cgcaacgggt ttgccgccag aacacgcgta aggtgagtct atgggaccct tgatgttttc 1320 tttccccttc ttttctatgg ttaagttcat gtcataggaa ggggagaagt aacagggtac 1380 acatattgac caaatcaggg taattttgca tttgtaattt taaaaaatgc tttcttcttt 1440 taatatactt ttttgtttat cttatttcta atactttccc taatctcttt ctttcagggc 1500 aataatgata caatgtatca tgcctctttg caccattcta aagaataaca gtgataattt 1560 ctgggttaag gcaatagcaa tatttctgca tataaatatt tctgcatata aattgtaact 1620 gatgtaagag gtttcatatt gctaatagca gctacaatcc agctaccatt ctgcttttat 1680 tttatggttg ggataaggct ggattattct gagtccaagc taggcccttt tgctaatcat 1740 gttcatacct cttatcttcc tcccacagca tagcggtacc tacccacagc caccatgtgg 1800 actctcgggc gccgcgcagt agccggcctc ctggcgtcac ccagcccagc ccaggcccag 1860 accctcaccc gggtcccgcg gccggcagag ttggccccac tctgcggccg ccgtggcctg 1920 cgcaccgaca tcgatgcgac ctgcacgccc cgccgcgcaa gttcgaacca acgtggcctc 1980 aaccagattt ggaatgtcaa aaagcagagt gtctatttga tgaatttgag gaaatctgga 2040 actttgggcc acccaggctc tctagatgag accacctatg aaagactagc agaggaaacg 2100 ctggactctt tagcagagtt ttttgaagac cttgcagaca agccatacac gtttgaggac 2160 tatgatgtct cctttgggag tggtgtctta actgtcaaac tgggtggaga tctaggaacc 2220 tatgtgatca acaagcagac gccaaacaag caaatctggc tatcttctcc atccagtgga 2280 cctaagcgtt atgactggac tgggaaaaac tgggtgtact cccacgacgg cgtgtccctc 2340 catgagctgc tggccgcaga gctcactaaa gccttaaaaa ccaaactgga cttgtcttcc 2400 ttggcctatt ccggaaaaga tgcttgattc taggatgggt ggcatccctg tgacccctcc 2460 ccagtgcctc tcctggccct ggaagttgcc actccagtgc ccaccagcct tgtcctaata 2520 aaattaagtt gcatcatttt gtctgactag gtgtccttct ataatattat ggggtggagg 2580 ggggtggtat ggagcaaggg gcaagttggg aagacaacct gtagggcctg cggggtctat 2640 tgggaaccaa gctggagtgc agtggcacaa tcttggctca ctgcaatctc cgcctcctgg 2700 gttcaagcga ttctcctgcc tcagcctccc gagttgttgg gattccaggc atgcatgacc 2760 aggctcagct aatttttgtt tttttggtag agacggggtt tcaccatatt ggccaggctg 2820 gtctccaact cctaatctca ggtgatctac ccaccttggc ctcccaaatt gctgggatta 2880 caggcgtgaa ccactgctcc cttccctgtc cttagatctg tgtaataaag gaaatttatt 2940 ttcattgcaa tagtgtgttg gaattttttg tgtctctcat aagtttttgt atgaatatgc 3000 aagaaggcat cctgattact ctgtcttgct gctgctgaga cttgccaaga cctatgaaac 3060 cactctagag aagtgctgtg cctctgcaga tcctcatgaa tgctatgcca aagtgttcag 3120 tgaatttaaa cctcttgtgg aagagcctca gaatttaatc aaacaaaatt gtgagctttt 3180 tgagcagctt ggagagtaca aattccagaa tgcactatta gttctttaca ccaagaaagt 3240 accccaagtg tcaactccaa ctcttgtaga ggtctcaaga aacctaggaa aagtgggcag 3300 caaatgttgt aaacatcctg aagcaaaaag aatgccctgt gcagaagact atctatcctt 3360 ggtcctgaac cagttatgtg tgttgcatga gaaaacacca gtaagtgaca gagtcaccaa 3420 atgctgcaca gaatccttgg tgaacaggca accatgcttt tcagctctgg aagttgatga 3480 agttggtttt gtaagcttta ccagatgagg aacccctagt gatggagttg gccactccct 3540 ctctgcgcgc tcgctcgctc actgaggccg ggcgaccaaa ggtcgcccga cgcccgggct 3600 ttgcccgggc ggcctcagtg agcgagcgag cgcgcagctg cctgcagg 3648 <210> 48 <211> 4127 <212> ADN <213> Secuencia artificial <220> <223> Casete de transferencia de AAV <400> 48 cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc 60 gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca 120 actccatcac taggggttcc taacttgcat atgcatgcag agacacagtt tttgctctgg 180 tgaattacat cttctttaaa ggcaaatggg agagaccctt tgaagtcaag gacacagagg 240 aagaggactt cctagtggac caggtgacca ccttgaaggt gcctatgtaa aagcatttag 300 gcatgtttaa catccagcac tgtaagaagc tgtccagctg ggtgctgctg taaaaatacc 360 tgggcaatgc caccaccatc ttcttcctgc ctgatgaggg gaaactacag cacctggaaa 420 atgaactcac ccactatatt atcaccaagt tcctggaaaa tgaagacaga aggtctgcca 480 gcttacattt acccaaactg tcaattactg gaacctatga tctgaagagc ttcctgggtc 540 aactgggcat cactaaggtc ttcagcaatg gggctgacct ctcctgggtc acagaggagg 600 cacccctgaa gctctccaag gccttgcata aggctgtgct gaccatcaat aagaaaggta 660 aaatacagca tagcaaaact ttaacctcca aatcaagcct ctacttgaat ccttttctga 720 gggatgaata aggcataggc atcaggggct gttgccaatg tgcattagct gtttgcagcc 780 tcaccttctt tcatggagtt taagatatag tgtattttcc caaggtttga actagctctt 840 catttcttta tgttttaaat gcactgacct cccacattcc ctttttagta aaatattcag 900 aaataattta aatacatcat tgcaatgaaa ataaatgttt tttattaggc agaatccaga 960 tgctcaaggc ccttcataat atcccccagt ttagtagttg gacttaggga acaaaggaac 1020 ctttaataga aattggacag caagaaagcg agcagtactc agtgggctcc ggtgcccgtc 1080 agtgggcaga gcgcacatcg cccacagtcc ccgagaagtt ggggggaggg gtcggcaatt 1140 gaaccggtgc ctagagaagg tggcgcgggg taaactggga aagtgatgtc gtgtactggc 1200 tccgcctttt tcccgagggt gggggagaac cgtatataag tgcagtagtc gccgtgaacg 1260 ttctttttcg caacgggttt gccgccagaa cacaggtaag tgccgtgtgt ggttcccgcg 1320 ggcctggcct ctttacgggt tatggccctt gcgtgccttg aattacttcc acgcccctgg 1380 ctgcagtacg tgattcttga tcccgagctt cgggttggaa gtgggtggga gagttcgagg 1440 ccttgcgctt aaggagcccc ttcgcctcgt gcttgagttg aggcctggcc tgggcgctgg 1500 ggccgccgcg tgcgaatctg gtggcacctt cgcgcctgtc tcgctgcttt cgataagtct 1560 ctagccattt aaaatttttg atgacctgct gcgacgcttt ttttctggca agatagtctt 1620 gtaaatgcgg gccaagatct gcacactggt atttcggttt ttggggccgc gggcggcgac 1680 ggggcccgtg cgtcccagcg cacatgttcg gcgaggcggg gcctgcgagc gcggccaccg 1740 agaatcggac gggggtagtc tcaagctggc cggcctgctc tggtgcctgg cctcgcgccg 1800 ccgtgtatcg ccccgccctg ggcggcaagg ctggcccggt cggcaccagt tgcgtgagcg 1860 gaaagatggc cgcttcccgg ccctgctgca gggagctcaa aatggaggac gcggcgctcg 1920 ggagagcggg cgggtgagtc acccacacaa aggaaaaggg cctttccgtc ctcagccgtc 1980 gcttcatgtg actccacgga gtaccgggcg ccgtccaggc acctcgatta gttctcgagc 2040 ttttggagta cgtcgtcttt aggttggggg gaggggtttt atgcgatgga gtttccccac 2100 actgagtggg tggagactga agttaggcca gcttggcact tgatgtaatt ctccttggaa 2160 tttgcccttt ttgagtttgg atcttggttc attctcaagc ctcagacagt ggttcaaagt 2220 ttttttcttc catttcaggt gtcgtgacat agcggtacct acccacagcc accatgtgga 2280 ctctcgggcg ccgcgcagta gccggcctcc tggcgtcacc cagcccagcc caggcccaga 2340 ccctcacccg ggtcccgcgg ccggcagagt tggccccact ctgcggccgc cgtggcctgc 2400 gcaccgacat cgatgcgacc tgcacgcccc gccgcgcaag ttcgaaccaa cgtggcctca 2460 accagatttg gaatgtcaaa aagcagagtg tctatttgat gaatttgagg aaatctggaa 2520 ctttgggcca cccaggctct ctagatgaga ccacctatga aagactagca gaggaaacgc 2580 tggactcttt agcagagttt tttgaagacc ttgcagacaa gccatacacg tttgaggact 2640 atgatgtctc ctttgggagt ggtgtcttaa ctgtcaaact gggtggagat ctaggaacct 2700 atgtgatcaa caagcagacg ccaaacaagc aaatctggct atcttctcca tccagtggac 2760 ctaagcgtta tgactggact gggaaaaact gggtgtactc ccacgacggc gtgtccctcc 2820 atgagctgct ggccgcagag ctcactaaag ccttaaaaac caaactggac ttgtcttcct 2880 tggcctattc cggaaaagat gcttgattct aggatgggtg gcatccctgt gacccctccc 2940 cagtgcctct cctggccctg gaagttgcca ctccagtgcc caccagcctt gtcctaataa 3000 aattaagttg catcattttg tctgactagg tgtccttcta taatattatg gggtggaggg 3060 gggtggtatg gagcaagggg caagttggga agacaacctg tagggcctgc ggggtctatt 3120 gggaaccaag ctggagtgca gtggcacaat cttggctcac tgcaatctcc gcctcctggg 3180 ttcaagcgat tctcctgcct cagcctcccg agttgttggg attccaggca tgcatgacca 3240 ggctcagcta atttttgttt ttttggtaga gacggggttt caccatattg gccaggctgg 3300 tctccaactc ctaatctcag gtgatctacc caccttggcc tcccaaattg ctgggattac 3360 aggcgtgaac cactgctccc ttccctgtcc ttagatctgt gtaataaagg aaatttattt 3420 tcattgcaat agtgtgttgg aattttttgt gtctctcata agtttttgta tgaatatgca 3480 agaaggcatc ctgattactc tgtcttgctg ctgctgagac ttgccaagac ctatgaaacc 3540 actctagaga agtgctgtgc ctctgcagat cctcatgaat gctatgccaa agtgttcagt 3600 gaatttaaac ctcttgtgga agagcctcag aatttaatca aacaaaattg tgagcttttt 3660 gagcagcttg gagagtacaa attccagaat gcactattag ttctttacac caagaaagta 3720 ccccaagtgt caactccaac tcttgtagag gtctcaagaa acctaggaaa agtgggcagc 3780 aaatgttgta aacatcctga agcaaaaaga atgccctgtg cagaagacta tctatccttg 3840 gtcctgaacc agttatgtgt gttgcatgag aaaacaccag taagtgacag agtcaccaaa 3900 tgctgcacag aatccttggt gaacaggcaa ccatgctttt cagctctgga agttgatgaa 3960 gttggttttg taagctttac cagatgagga acccctagtg atggagttgg ccactccctc 4020 tctgcgcgct cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt 4080 tgcccgggcg gcctcagtga gcgagcgagc gcgcagctgc ctgcagg 4127 <210> 49 <211> 3932 <212> ADN <213> Secuencia artificial <220> <223> Casete de transferencia de AAV <400> 49 cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc 60 gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca 120 actccatcac taggggttcc taacttgcat atgcatgcag agacacagtt tttgctctgg 180 tgaattacat cttctttaaa ggcaaatggg agagaccctt tgaagtcaag gacacagagg 240 aagaggactt cctagtggac caggtgacca ccttgaaggt gcctatgtaa aagcatttag 300 gcatgtttaa catccagcac tgtaagaagc tgtccagctg ggtgctgctg taaaaatacc 360 tgggcaatgc caccaccatc ttcttcctgc ctgatgaggg gaaactacag cacctggaaa 420 atgaactcac ccactatatt atcaccaagt tcctggaaaa tgaagacaga aggtctgcca 480 gcttacattt acccaaactg tcaattactg gaacctatga tctgaagagc ttcctgggtc 540 aactgggcat cactaaggtc ttcagcaatg gggctgacct ctcctgggtc acagaggagg 600 cacccctgaa gctctccaag gccttgcata aggctgtgct gaccatcaat aagaaaggta 660 aaatacagca tagcaaaact ttaacctcca aatcaagcct ctacttgaat ccttttctga 720 gggatgaata aggcataggc atcaggggct gttgccaatg tgcattagct gtttgcagcc 780 tcaccttctt tcatggagtt taagatatag tgtattttcc caaggtttga actagctctt 840 catttcttta tgttttaaat gcactgacct cccacattcc ctttttagta aaatattcag 900 aaataattta aatacatcat tgcaatgaaa ataaatgttt tttattaggc agaatccaga 960 tgctcaaggc ccttcataat atcccccagt ttagtagttg gacttaggga acaaaggaac 1020 ctttaataga aattggacag caagaaagcg agcagtactc agtggggggt tggggttgcg 1080 ccttttccaa ggcagccctg ggtttgcgca gggacgcggc tgctctgggc gtggttccgg 1140 gaaacgcagc ggcgccgacc ctgggtctcg cacattcttc acgtccgttc gcagcgtcac 1200 ccggatcttc gccgctaccc ttgtgggccc cccggcgacg cttcctgctc cgcccctaag 1260 tcgggaaggt tccttgcggt tcgcggcgtg ccggacgtga caaacggaag ccgcacgtct 1320 cactagtacc ctcgcagacg gacagcgcca gggagcaatg gcagcgcgcc gaccgcgatg 1380 ggctgtggcc aatagcggct gctcagcagg gcgcgccgag agcagcggcc gggaaggggc 1440 ggtgcgggag gcggggtgtg gggcggtagt gtgggccctg ttcctgcccg cgcggtgttc 1500 cgcattctgc aagcctccgg agcgcacgtc ggcagtcggc tccctcgttg accgaatcac 1560 cgacctctct ccccaggtga gtctatggga cccttgatgt tttctttccc cttcttttct 1620 atggttaagt tcatgtcata ggaaggggag aagtaacagg gtacacatat tgaccaaatc 1680 agggtaattt tgcatttgta attttaaaaa atgctttctt cttttaatat acttttttgt 1740 ttatcttatt tctaatactt tccctaatct ctttctttca gggcaataat gatacaatgt 1800 atcatgcctc tttgcaccat tctaaagaat aacagtgata atttctgggt taaggcaata 1860 gcaatatttc tgcatataaa tatttctgca tataaattgt aactgatgta agaggtttca 1920 tattgctaat agcagctaca atccagctac cattctgctt ttattttatg gttgggataa 1980 ggctggatta ttctgagtcc aagctaggcc cttttgctaa tcatgttcat acctcttatc 2040 ttcctcccac agcatagcgg tacctaccca cagccaccat gtggactctc gggcgccgcg 2100 cagtagccgg cctcctggcg tcacccagcc cagcccaggc ccagaccctc acccgggtcc 2160 cgcggccggc agagttggcc ccactctgcg gccgccgtgg cctgcgcacc gacatcgatg 2220 cgacctgcac gccccgccgc gcaagttcga accaacgtgg cctcaaccag atttggaatg 2280 tcaaaaagca gagtgtctat ttgatgaatt tgaggaaatc tggaactttg ggccacccag 2340 gctctctaga tgagaccacc tatgaaagac tagcagagga aacgctggac tctttagcag 2400 agttttttga agaccttgca gacaagccat acacgtttga ggactatgat gtctcctttg 2460 ggagtggtgt cttaactgtc aaactgggtg gagatctagg aacctatgtg atcaacaagc 2520 agacgccaaa caagcaaatc tggctatctt ctccatccag tggacctaag cgttatgact 2580 ggactgggaa aaactgggtg tactcccacg acggcgtgtc cctccatgag ctgctggccg 2640 cagagctcac taaagcctta aaaaccaaac tggacttgtc ttccttggcc tattccggaa 2700 aagatgcttg attctaggat gggtggcatc cctgtgaccc ctccccagtg cctctcctgg 2760 ccctggaagt tgccactcca gtgcccacca gccttgtcct aataaaatta agttgcatca 2820 ttttgtctga ctaggtgtcc ttctataata ttatggggtg gaggggggtg gtatggagca 2880 aggggcaagt tgggaagaca acctgtaggg cctgcggggt ctattgggaa ccaagctgga 2940 gtgcagtggc acaatcttgg ctcactgcaa tctccgcctc ctgggttcaa gcgattctcc 3000 tgcctcagcc tcccgagttg ttgggattcc aggcatgcat gaccaggctc agctaatttt 3060 tgtttttttg gtagagacgg ggtttcacca tattggccag gctggtctcc aactcctaat 3120 ctcaggtgat ctacccacct tggcctccca aattgctggg attacaggcg tgaaccactg 3180 ctcccttccc tgtccttaga tctgtgtaat aaaggaaatt tattttcatt gcaatagtgt 3240 gttggaattt tttgtgtctc tcataagttt ttgtatgaat atgcaagaag gcatcctgat 3300 tactctgtct tgctgctgct gagacttgcc aagacctatg aaaccactct agagaagtgc 3360 tgtgcctctg cagatcctca tgaatgctat gccaaagtgt tcagtgaatt taaacctctt 3420 gtggaagagc ctcagaattt aatcaaacaa aattgtgagc tttttgagca gcttggagag 3480 tacaaattcc agaatgcact attagttctt tacaccaaga aagtacccca agtgtcaact 3540 ccaactcttg tagaggtctc aagaaaccta ggaaaagtgg gcagcaaatg ttgtaaacat 3600 cctgaagcaa aaagaatgcc ctgtgcagaa gactatctat ccttggtcct gaaccagtta 3660 tgtgtgttgc atgagaaaac accagtaagt gacagagtca ccaaatgctg cacagaatcc 3720 ttggtgaaca ggcaaccatg cttttcagct ctggaagttg atgaagttgg ttttgtaagc 3780 tttaccagat gaggaacccc tagtgatgga gttggccact ccctctctgc gcgctcgctc 3840 gctcactgag gccgggcgac caaaggtcgc ccgacgcccg ggctttgccc gggcggcctc 3900 agtgagcgag cgagcgcgca gctgcctgca gg 3932 <210> 50 <211> 3378 <212> ADN <213> Secuencia artificial <220> <223> Casete de transferencia de AAV <400> 50 cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc 60 gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca 120 actccatcac taggggttcc taacttgcat atgcatgcta aaatacagca tagcaaaact 180 ttaacctcca aatcaagcct ctacttgaat ccttttctga gggatgaata aggcataggc 240 atcaggggct gttgccaatg tgcattagct gtttgcagcc tcaccttctt tcatggagtt 300 taagatatag tgtattttcc caaggtttga actagctctt catttcttta tgttttaaat 360 gcactgacct cccacattcc ctttttagta aaatattcag aaataattta aatacatcat 420 tgcaatgaaa ataaatgttt tttattaggc agaatccaga tgctcaaggc ccttcataat 480 atcccccagt ttagtagttg gacttaggga acaaaggaac ctttaataga aattggacag 540 caagaaagcg agcagtactc agtgggcccg tcagtgggca gagcgcacat cgcccacagt 600 ccccgagaag ttggggggag gggtcggcaa ttgaaccggt gcctagagaa ggtggcgcgg 660 ggtaaactgg gaaagtgatg tcgtgtactg gctccgcctt tttcccgagg gtgggggaga 720 accgtatata agtgcagtag tcgccgtgaa cgttcttttt cgcaacgggt ttgccgccag 780 aacacgcgta agggagtcgc tgcgacgctg ccttcgcccc gtgccccgct ccgccgccgc 840 ctcgcgccgc ccgccccggc tctgactgac cgcgttactc ccacaggtga gcgggcggga 900 cggcccttct cctccgggct gtaattagcg cttggtttaa tgacggcttg tttcttttct 960 gtggctgcgt gaaagccttg aggggctccg ggagggccct ttgtgcgggg gggagcggct 1020 cggggggtgc gtgcgtgtgt gtgtgcgtgg ggagcgccgc gtgcggcccg cgctgcccgg 1080 cggctgtgag cgctgcgggc gcggcgcggg gctttgtgcg ctccgcagtg tgcgcgaggg 1140 gagcgcggcc gggggcggtg ccccgcggtg cggggggggc tgcgagggga acaaaggctg 1200 cgtgcggggt gtgtgcgtgg gggggtgagc agggggtatg ggcgcggcgg tcgggctgta 1260 acccccccct gcacccccct ccccgagttg ctgagcacgg cccggcttcg ggtgcggggc 1320 tccgtacggg gcgtggcgcg gggctcgccg tgccgggcgg ggggtggcgg caggtggggg 1380 tgccgggcgg ggcggggccg cctcgggccg gggagggctc gggggagggg cgcggcggcc 1440 cccggagcgc cggcggctgt cgaggcgcgg cgagccgcag ccattgcctt ttatggtaat 1500 cgtgcgagag ggcgcaggga cttactttgt cccaaatctg tgcggagccg aaatctggga 1560 ggcgccgccg caccccctct agcgggcgcg gggcgaagcg gtgcggcgcc ggcaggaagg 1620 aaatgggcgg ggagggcctt cgtgcgtcgc cgcgccgccg tccccttctc cctctccagc 1680 ctcggggctg tccgcggggg gacggctgcc ttcggggggg acggggcagg gcggggttcg 1740 gcttctggcg tgtgaccggc ggctctagag cctctgctaa ccatgttcat gccttcttct 1800 ttttcctaca gctcctgggc aacgtgctgg ttattgtgct gtctcatcat tttggcaaag 1860 aattctaaat agcggtacct acccacagcc accatgtgga ctctcgggcg ccgcgcagta 1920 gccggcctcc tggcgtcacc cagcccagcc caggcccaga ccctcacccg ggtcccgcgg 1980 ccggcagagt tggccccact ctgcggccgc cgtggcctgc gcaccgacat cgatgcgacc 2040 tgcacgcccc gccgcgcaag ttcgaaccaa cgtggcctca accagatttg gaatgtcaaa 2100 aagcagagtg tctatttgat gaatttgagg aaatctggaa ctttgggcca cccaggctct 2160 ctagatgaga ccacctatga aagactagca gaggaaacgc tggactcttt agcagagttt 2220 tttgaagacc ttgcagacaa gccatacacg tttgaggact atgatgtctc ctttgggagt 2280 ggtgtcttaa ctgtcaaact gggtggagat ctaggaacct atgtgatcaa caagcagacg 2340 ccaaacaagc aaatctggct atcttctcca tccagtggac ctaagcgtta tgactggact 2400 gggaaaaact gggtgtactc ccacgacggc gtgtccctcc atgagctgct ggccgcagag 2460 ctcactaaag ccttaaaaac caaactggac ttgtcttcct tggcctattc cggaaaagat 2520 gcttgattct aggatgggtg gcatccctgt gacccctccc cagtgcctct cctggccctg 2580 gaagttgcca ctccagtgcc caccagcctt gtcctaataa aattaagttg catcattttg 2640 tctgactagg tgtccttcta taatattatg gggtggaggg gggtggtatg gagcaagggg 2700 caagttggga agacaacctg tagggcctgc ggggtctatt gggaaccaag ctggagtgca 2760 gtggcacaat cttggctcac tgcaatctcc gcctcctggg ttcaagcgat tctcctgcct 2820 cagcctcccg agttgttggg attccaggca tgcatgacca ggctcagcta atttttgttt 2880 ttttggtaga gacggggttt caccatattg gccaggctgg tctccaactc ctaatctcag 2940 gtgatctacc caccttggcc tcccaaattg ctgggattac aggcgtgaac cactgctccc 3000 ttccctgtcc ttagatctgt gtaataaagg aaatttattt tcattgcaat agtgtgttgg 3060 aattttttgt gtctctcagt tggttgtaag tatcaaggtt acaagacagg tttaaggaga 3120 ccaatagaaa ctgggcttgt cgagacagag aagactcttg cgtttctgat aggcacctat 3180 tggtcttact gacatccact ttgcctttct ctccacagtt gtaagcttta ccagatgagg 3240 aacccctagt gatggagttg gccactccct ctctgcgcgc tcgctcgctc actgaggccg 3300 ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag 3360 cgcgcagctg cctgcagg 3378 <210> 51 <211> 2247 <212> ADN <213> Secuencia artificial <220> <223> Casete de transferencia de AAV <400> 51 cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc 60 gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca 120 actccatcac taggggttcc taacttgcat atgcatgggg cagagcgcac atcgcccaca 180 gtccccgaga agttgggggg aggggtcggc aattgaaccg gtgcctagag aaggtggcgc 240 ggggtaaact gggaaagtga tgtcgtgtac tggctccgcc tttttcccga gggtggggga 300 gaaccgtata taagtgcagt agtcgccgtg aacgttcttt ttcgcaacgg gtttgccgcc 360 agaacacgcc tcagtgagtc tatgggaccc ttgatgtttt ctttcccctt cttttctatg 420 gttaagttca tgtcatagga aggggagaag taacagggta cacatattga ccaaatcagg 480 gtaattttgc atttgtaatt ttaaaaaatg ctttcttctt ttaatatact tttttgttta 540 tcttatttct aatactttcc ctaatctctt tctttcaggg caataatgat acaatgtatc 600 atgcctcttt gcaccattct aaagaataac agtgataatt tctgggttaa ggcaatagca 660 atatttctgc atataaatat ttctgcatat aaattgtaac tgatgtaaga ggtttcatat 720 tgctaatagc agctacaatc cagctaccat tctgctttta ttttatggtt gggataaggc 780 tggattattc tgagtccaag ctaggccctt ttgctaatca tgttcatacc tcttatcttc 840 ctcccacagg gtacctaccc acagccacca tgtggactct ggggaggaga gcagtagctg 900 gcctcctggc atcacccagc ccagcccagg cccagaccct caccagggtc cctagaccag 960 cagagttggc cccactctgt ggcaggagag gcctgaggac agacattgat gccacctgca 1020 cccccaggag agcaagttcc aaccaaagag gcctcaacca gatttggaat gtcaaaaagc 1080 agagtgtcta tttgatgaat ttgaggaaat ctggaacttt gggccaccca ggctctctag 1140 atgagaccac ctatgaaaga ctagcagagg aaacactgga ctctttagca gagttttttg 1200 aagaccttgc agacaagcca tacacctttg aggactatga tgtctccttt gggagtggtg 1260 tcttaactgt caaactgggt ggagatctag gaacctatgt gatcaacaag cagactccaa 1320 acaagcaaat ctggctatct tctccatcca gtggacctaa gaggtatgac tggactggga 1380 aaaactgggt gtactcccat gatggagtgt ccctccatga gctgctggct gcagagctca 1440 ctaaagcctt aaaaaccaaa ctggacttgt cttccttggc ctattctgga aaagatgctt 1500 gataagttta aacttctagg atgctcgctt tcttgctgtc caatttctat taaaggttcc 1560 tttgttccct aagtccaact actaaactgg gggatattat gaagggcctt gagcatctgg 1620 attctgccta ataaaaaaca tttattttca ttgcaatgat gtatttaaat tatttctgaa 1680 tattttacta aaaagggaat gtgggaggtc agtgcattta aaacataaag aaatgaagag 1740 ctagttcaaa ccttgggaaa atacactata tcttaaactc catgaaagaa ggtgaggctg 1800 caaacagcta atgcacattg gcaacagccc ctgatgccta tgccttattc atccctcaga 1860 aaaggattca agtagaggct tgatttggag gttaaagttt tgctatgctg tattttaaga 1920 tctgtgtaat aaaggaaatt tattttcatt gcaatagtgt gttggaattt tttgtgtctc 1980 tcagttggtt gtaagtatca aggttacaag acaggtttaa ggagaccaat agaaactggg 2040 cttgtcgaga cagagaagac tcttgcgttt ctgataggca cctattggtc ttactgacat 2100 ccactttgcc tttctctcca cagtaagctt taccccactc cctctctgcg cgctcgctcg 2160 ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca 2220 gtgagcgagc gagcgcgcag agaggga 2247 <210> 52 <211> 2166 <212> ADN <213> Secuencia artificial <220> <223> Casete de transferencia de AAV <400> 52 cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc 60 gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca 120 actccatcac taggggttcc taacttgcat atgcatgggg cagagcgcac atcgcccaca 180 gtccccgaga agttgggggg aggggtcggc aattgaaccg gtgcctagag aaggtggcgc 240 ggggtaaact gggaaagtga tgtcgtgtac tggctccgcc tttttcccga gggtggggga 300 gaaccgtata taagtgcagt agtcgccgtg aacgttcttt ttcgcaacgg gtttgccgcc 360 agaacacgcc tcagtgagtc tatgggaccc ttgatgtttt ctttcccctt cttttctatg 420 gttaagttca tgtcatagga aggggagaag taacagggta cacatattga ccaaatcagg 480 gtaattttgc atttgtaatt ttaaaaaatg ctttcttctt ttaatatact tttttgttta 540 tcttatttct aatactttcc ctaatctctt tctttcaggg caataatgat acaatgtatc 600 atgcctcttt gcaccattct aaagaataac agtgataatt tctgggttaa ggcaatagca 660 atatttctgc atataaatat ttctgcatat aaattgtaac tgatgtaaga ggtttcatat 720 tgctaatagc agctacaatc cagctaccat tctgctttta ttttatggtt gggataaggc 780 tggattattc tgagtccaag ctaggccctt ttgctaatca tgttcatacc tcttatcttc 840 ctcccacagg gtacctaccc acagccacca tgtggactct ggggaggaga gcagtagctg 900 gcctcctggc atcacccagc ccagcccagg cccagaccct caccagggtc cctagaccag 960 cagagttggc cccactctgt ggcaggagag gcctgaggac agacattgat gccacctgca 1020 cccccaggag agcaagttcc aaccaaagag gcctcaacca gatttggaat gtcaaaaagc 1080 agagtgtcta tttgatgaat ttgaggaaat ctggaacttt gggccaccca ggctctctag 1140 atgagaccac ctatgaaaga ctagcagagg aaacactgga ctctttagca gagttttttg 1200 aagaccttgc agacaagcca tacacctttg aggactatga tgtctccttt gggagtggtg 1260 tcttaactgt caaactgggt ggagatctag gaacctatgt gatcaacaag cagactccaa 1320 acaagcaaat ctggctatct tctccatcca gtggacctaa gaggtatgac tggactggga 1380 aaaactgggt gtactcccat gatggagtgt ccctccatga gctgctggct gcagagctca 1440 ctaaagcctt aaaaaccaaa ctggacttgt cttccttggc ctattctgga aaagatgctt 1500 gataacgact gcaggtaggt ttaaacaagc ttggtaccgt gattaatctt cgaatgactg 1560 acgggtggca tccctgtgac ccctccccag tgcctctcct ggccctggaa gttgccactc 1620 cagtgcccac cagccttgtc ctaataaaat taagttgcat cattttgtct gactaggtgt 1680 ccttctataa tattatgggg tggagggggg tggtatggag caaggggcaa gttgggaaga 1740 caacctgtag ggcctgcggg gtctattggg aaccaagctg gagtgcagtg gcacaatctt 1800 ggctcactgc aatctccgcc tcctgggttc aagcgattct cctgcctcag cctcccgagt 1860 tgttgggatt ccaggcatgc atgaccaggc tcagctaatt tttgtttttt tggtagagac 1920 ggggtttcac catattggcc aggctggtct ccaactccta atctcaggtg atctacccac 1980 cttggcctcc caaattgctg ggattacagg cgtgaaccac tgctcccttc cctgtcctta 2040 gataagcttt accccactcc ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca 2100 aaggtcgccc gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg agcgcgcaga 2160 gaggga 2166 <210> 53 <211> 3062 <212> ADN <213> Secuencia artificial <220> <223> Casete de transferencia de AAV <400> 53 cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc 60 gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca 120 actccatcac taggggttcc taacttgcat atgcatgcta aaatacagca tagcaaaact 180 ttaacctcca aatcaagcct ctacttgaat ccttttctga gggatgaata aggcataggc 240 atcaggggct gttgccaatg tgcattagct gtttgcagcc tcaccttctt tcatggagtt 300 taagatatag tgtattttcc caaggtttga actagctctt catttcttta tgttttaaat 360 gcactgacct cccacattcc ctttttagta aaatattcag aaataattta aatacatcat 420 tgcaatgaaa ataaatgttt tttattaggc agaatccaga tgctcaaggc ccttcataat 480 atcccccagt ttagtagttg gacttaggga acaaaggaac ctttaataga aattggacag 540 caagaaagcg agcagtactc agtggggggt tggggttgcg ccttttccaa ggcagccctg 600 ggtttgcgca gggacgcggc tgctctgggc gtggttccgg gaaacgcagc ggcgccgacc 660 ctgggtctcg cacattcttc acgtccgttc gcagcgtcac ccggatcttc gccgctaccc 720 ttgtgggccc cccggcgacg cttcctgctc cgcccctaag tcgggaaggt tccttgcggt 780 tcgcggcgtg ccggacgtga caaacggaag ccgcacgtct cactagtacc ctcgcagacg 840 gacagcgcca gggagcaatg gcagcgcgcc gaccgcgatg ggctgtggcc aatagcggct 900 gctcagcagg gcgcgccgag agcagcggcc gggaaggggc ggtgcgggag gcggggtgtg 960 gggcggtagt gtgggccctg ttcctgcccg cgcggtgttc cgcattctgc aagcctccgg 1020 agcgcacgtc ggcagtcggc tccctcgttg accgaatcac cgacctctct ccccaggtga 1080 gtctatggga cccttgatgt tttctttccc cttcttttct atggttaagt tcatgtcata 1140 ggaaggggag aagtaacagg gtacacatat tgaccaaatc agggtaattt tgcatttgta 1200 attttaaaaa atgctttctt cttttaatat acttttttgt ttatcttatt tctaatactt 1260 tccctaatct ctttctttca gggcaataat gatacaatgt atcatgcctc tttgcaccat 1320 tctaaagaat aacagtgata atttctgggt taaggcaata gcaatatttc tgcatataaa 1380 tatttctgca tataaattgt aactgatgta agaggtttca tattgctaat agcagctaca 1440 atccagctac cattctgctt ttattttatg gttgggataa ggctggatta ttctgagtcc 1500 aagctaggcc cttttgctaa tcatgttcat acctcttatc ttcctcccac agcatagcgg 1560 tacctacccg gagcagcatg tggactctcg ggcgccgcgc agtagccggc ctcctggcgt 1620 cacccagccc agcccaggcc cagaccctca cccgggtccc gcggccggca gagttggccc 1680 cactctgcgg ccgccgtggc ctgcgcaccg acatcgatgc gacctgcacg ccccgccgcg 1740 caagttcgaa ccaacgtggc ctcaaccaga tttggaatgt caaaaagcag agtgtctatt 1800 tgatgaattt gaggaaatct ggaactttgg gccacccagg ctctctagat gagaccacct 1860 atgaaagact agcagaggaa acgctggact ctttagcaga gttttttgaa gaccttgcag 1920 acaagccata cacgtttgag gactatgatg tctcctttgg gagtggtgtc ttaactgtca 1980 aactgggtgg agatctagga acctatgtga tcaacaagca gacgccaaac aagcaaatct 2040 ggctatcttc tccatccagt ggacctaagc gttatgactg gactgggaaa aactgggtgt 2100 actcccacga cggcgtgtcc ctccatgagc tgctggccgc agagctcact aaagccttaa 2160 aaaccaaact ggacttgtct tccttggcct attccggaaa agatgcttga ttctaggatg 2220 ggtggcatcc ctgtgacccc tccccagtgc ctctcctggc cctggaagtt gccactccag 2280 tgcccaccag ccttgtccta ataaaattaa gttgcatcat tttgtctgac taggtgtcct 2340 tctataatat tatggggtgg aggggggtgg tatggagcaa ggggcaagtt gggaagacaa 2400 cctgtagggc ctgcggggtc tattgggaac caagctggag tgcagtggca caatcttggc 2460 tcactgcaat ctccgcctcc tgggttcaag cgattctcct gcctcagcct cccgagttgt 2520 tgggattcca ggcatgcatg accaggctca gctaattttt gtttttttgg tagagacggg 2580 gtttcaccat attggccagg ctggtctcca actcctaatc tcaggtgatc tacccacctt 2640 ggcctcccaa attgctggga ttacaggcgt gaaccactgc tcccttccct gtccttagat 2700 ctgtgtaata aaggaaattt attttcattg caatagtgtg ttggaatttt ttgtgtctct 2760 cagttggttg taagtatcaa ggttacaaga caggtttaag gagaccaata gaaactgggc 2820 ttgtcgagac agagaagact cttgcgtttc tgataggcac ctattggtct tactgacatc 2880 cactttgcct ttctctccac agttgtaagc tttaccagat gaggaacccc tagtgatgga 2940 gttggccact ccctctctgc gcgctcgctc gctcactgag gccgggcgac caaaggtcgc 3000 ccgacgcccg ggctttgccc gggcggcctc agtgagcgag cgagcgcgca gctgcctgca 3060 gg 3062 <210> 54 <211> 3698 <212> ADN <213> Secuencia artificial <220> <223> Casete de transferencia de AAV <400> 54 cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc 60 gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca 120 actccatcac taggggttcc taacttgcat atgcatgcag agacacagtt tttgctctgg 180 tgaattacat cttctttaaa ggcaaatggg agagaccctt tgaagtcaag gacacagagg 240 aagaggactt cctagtggac caggtgacca ccttgaaggt gcctatgtaa aagcatttag 300 gcatgtttaa catccagcac tgtaagaagc tgtccagctg ggtgctgctg taaaaatacc 360 tgggcaatgc caccaccatc ttcttcctgc ctgatgaggg gaaactacag cacctggaaa 420 atgaactcac ccactatatt atcaccaagt tcctggaaaa tgaagacaga aggtctgcca 480 gcttacattt acccaaactg tcaattactg gaacctatga tctgaagagc ttcctgggtc 540 aactgggcat cactaaggtc ttcagcaatg gggctgacct ctcctgggtc acagaggagg 600 cacccctgaa gctctccaag gccttgcata aggctgtgct gaccatcaat aagaaaggta 660 aaatacagca tagcaaaact ttaacctcca aatcaagcct ctacttgaat ccttttctga 720 gggatgaata aggcataggc atcaggggct gttgccaatg tgcattagct gtttgcagcc 780 tcaccttctt tcatggagtt taagatatag tgtattttcc caaggtttga actagctctt 840 catttcttta tgttttaaat gcactgacct cccacattcc ctttttagta aaatattcag 900 aaataattta aatacatcat tgcaatgaaa ataaatgttt tttattaggc agaatccaga 960 tgctcaaggc ccttcataat atcccccagt ttagtagttg gacttaggga acaaaggaac 1020 ctttaataga aattggacag caagaaagcg agcagtactc agtggtcgag gtgagcccca 1080 cgttctgctt cactctcccc atctcccccc cctccccacc cccaattttg tatttattta 1140 ttttttaatt attttgtgca gcgatggggg cggggggggg gggggggcgc gcgccaggcg 1200 gggcggggcg gggcgagggg cggggcgggg cgaggcggag aggtgcggcg gcagccaatc 1260 agagcggcgc gctccgaaag tttcctttta tggcgaggcg gcggcggcgg cggccctata 1320 aaaagcgaag cgcgcggcgg gcggtgagtc tatgggaccc ttgatgtttt ctttcccctt 1380 cttttctatg gttaagttca tgtcatagga aggggagaag taacagggta cacatattga 1440 ccaaatcagg gtaattttgc atttgtaatt ttaaaaaatg ctttcttctt ttaatatact 1500 tttttgttta tcttatttct aatactttcc ctaatctctt tctttcaggg caataatgat 1560 acaatgtatc atgcctcttt gcaccattct aaagaataac agtgataatt tctgggttaa 1620 ggcaatagca atatttctgc atataaatat ttctgcatat aaattgtaac tgatgtaaga 1680 ggtttcatat tgctaatagc agctacaatc cagctaccat tctgctttta ttttatggtt 1740 gggataaggc tggattattc tgagtccaag ctaggccctt ttgctaatca tgttcatacc 1800 tcttatcttc ctcccacagc atagcggtac ctacccggag cagcatgtgg actctcgggc 1860 gccgcgcagt agccggcctc ctggcgtcac ccagcccagc ccaggcccag accctcaccc 1920 gggtcccgcg gccggcagag ttggccccac tctgcggccg ccgtggcctg cgcaccgaca 1980 tcgatgcgac ctgcacgccc cgccgcgcaa gttcgaacca acgtggcctc aaccagattt 2040 ggaatgtcaa aaagcagagt gtctatttga tgaatttgag gaaatctgga actttgggcc 2100 acccaggctc tctagatgag accacctatg aaagactagc agaggaaacg ctggactctt 2160 tagcagagtt ttttgaagac cttgcagaca agccatacac gtttgaggac tatgatgtct 2220 cctttgggag tggtgtctta actgtcaaac tgggtggaga tctaggaacc tatgtgatca 2280 acaagcagac gccaaacaag caaatctggc tatcttctcc atccagtgga cctaagcgtt 2340 atgactggac tgggaaaaac tgggtgtact cccacgacgg cgtgtccctc catgagctgc 2400 tggccgcaga gctcactaaa gccttaaaaa ccaaactgga cttgtcttcc ttggcctatt 2460 ccggaaaaga tgcttgattc taggatgggt ggcatccctg tgacccctcc ccagtgcctc 2520 tcctggccct ggaagttgcc actccagtgc ccaccagcct tgtcctaata aaattaagtt 2580 gcatcatttt gtctgactag gtgtccttct ataatattat ggggtggagg ggggtggtat 2640 ggagcaaggg gcaagttggg aagacaacct gtagggcctg cggggtctat tgggaaccaa 2700 gctggagtgc agtggcacaa tcttggctca ctgcaatctc cgcctcctgg gttcaagcga 2760 ttctcctgcc tcagcctccc gagttgttgg gattccaggc atgcatgacc aggctcagct 2820 aatttttgtt tttttggtag agacggggtt tcaccatatt ggccaggctg gtctccaact 2880 cctaatctca ggtgatctac ccaccttggc ctcccaaatt gctgggatta caggcgtgaa 2940 ccactgctcc cttccctgtc cttagatctg tgtaataaag gaaatttatt ttcattgcaa 3000 tagtgtgttg gaattttttg tgtctctcat aagtttttgt atgaatatgc aagaaggcat 3060 cctgattact ctgtcttgct gctgctgaga cttgccaaga cctatgaaac cactctagag 3120 aagtgctgtg cctctgcaga tcctcatgaa tgctatgcca aagtgttcag tgaatttaaa 3180 cctcttgtgg aagagcctca gaatttaatc aaacaaaatt gtgagctttt tgagcagctt 3240 ggagagtaca aattccagaa tgcactatta gttctttaca ccaagaaagt accccaagtg 3300 tcaactccaa ctcttgtaga ggtctcaaga aacctaggaa aagtgggcag caaatgttgt 3360 aaacatcctg aagcaaaaag aatgccctgt gcagaagact atctatcctt ggtcctgaac 3420 cagttatgtg tgttgcatga gaaaacacca gtaagtgaca gagtcaccaa atgctgcaca 3480 gaatccttgg tgaacaggca accatgcttt tcagctctgg aagttgatga agttggtttt 3540 gtaagcttta ccagatgagg aacccctagt gatggagttg gccactccct ctctgcgcgc 3600 tcgctcgctc actgaggccg ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc 3660 ggcctcagtg agcgagcgag cgcgcagctg cctgcagg 3698 <210> 55 <211> 3647 <212> ADN <213> Secuencia artificial <220> <223> Casete de transferencia de AAV <400> 55 cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc 60 gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca 120 actccatcac taggggttcc taacttgcat atgcatgcag agacacagtt tttgctctgg 180 tgaattacat cttctttaaa ggcaaatggg agagaccctt tgaagtcaag gacacagagg 240 aagaggactt cctagtggac caggtgacca ccttgaaggt gcctatgtaa aagcatttag 300 gcatgtttaa catccagcac tgtaagaagc tgtccagctg ggtgctgctg taaaaatacc 360 tgggcaatgc caccaccatc ttcttcctgc ctgatgaggg gaaactacag cacctggaaa 420 atgaactcac ccactatatt atcaccaagt tcctggaaaa tgaagacaga aggtctgcca 480 gcttacattt acccaaactg tcaattactg gaacctatga tctgaagagc ttcctgggtc 540 aactgggcat cactaaggtc ttcagcaatg gggctgacct ctcctgggtc acagaggagg 600 cacccctgaa gctctccaag gccttgcata aggctgtgct gaccatcaat aagaaaggta 660 aaatacagca tagcaaaact ttaacctcca aatcaagcct ctacttgaat ccttttctga 720 gggatgaata aggcataggc atcaggggct gttgccaatg tgcattagct gtttgcagcc 780 tcaccttctt tcatggagtt taagatatag tgtattttcc caaggtttga actagctctt 840 catttcttta tgttttaaat gcactgacct cccacattcc ctttttagta aaatattcag 900 aaataattta aatacatcat tgcaatgaaa ataaatgttt tttattaggc agaatccaga 960 tgctcaaggc ccttcataat atcccccagt ttagtagttg gacttaggga acaaaggaac 1020 ctttaataga aattggacag caagaaagcg agcagtactc agtgggcccg tcagtgggca 1080 gagcgcacat cgcccacagt ccccgagaag ttggggggag gggtcggcaa ttgaaccggt 1140 gcctagagaa ggtggcgcgg ggtaaactgg gaaagtgatg tcgtgtactg gctccgcctt 1200 tttcccgagg gtgggggaga accgtatata agtgcagtag tcgccgtgaa cgttcttttt 1260 cgcaacgggt ttgccgccag aacacgcgta aggtgagtct atgggaccct tgatgttttc 1320 tttccccttc ttttctatgg ttaagttcat gtcataggaa ggggagaagt aacagggtac 1380 acatattgac caaatcaggg taattttgca tttgtaattt taaaaaatgc tttcttcttt 1440 taatatactt ttttgtttat cttatttcta atactttccc taatctcttt ctttcagggc 1500 aataatgata caatgtatca tgcctctttg caccattcta aagaataaca gtgataattt 1560 ctgggttaag gcaatagcaa tatttctgca tataaatatt tctgcatata aattgtaact 1620 gatgtaagag gtttcatatt gctaatagca gctacaatcc agctaccatt ctgcttttat 1680 tttatggttg ggataaggct ggattattct gagtccaagc taggcccttt tgctaatcat 1740 gttcatacct cttatcttcc tcccacagca tagcggtacc tacccggagc agcatgtgga 1800 ctctcgggcg ccgcgcagta gccggcctcc tggcgtcacc cagcccagcc caggcccaga 1860 ccctcacccg ggtcccgcgg ccggcagagt tggccccact ctgcggccgc cgtggcctgc 1920 gcaccgacat cgatgcgacc tgcacgcccc gccgcgcaag ttcgaaccaa cgtggcctca 1980 accagatttg gaatgtcaaa aagcagagtg tctatttgat gaatttgagg aaatctggaa 2040 ctttgggcca cccaggctct ctagatgaga ccacctatga aagactagca gaggaaacgc 2100 tggactcttt agcagagttt tttgaagacc ttgcagacaa gccatacacg tttgaggact 2160 atgatgtctc ctttgggagt ggtgtcttaa ctgtcaaact gggtggagat ctaggaacct 2220 atgtgatcaa caagcagacg ccaaacaagc aaatctggct atcttctcca tccagtggac 2280 ctaagcgtta tgactggact gggaaaaact gggtgtactc ccacgacggc gtgtccctcc 2340 atgagctgct ggccgcagag ctcactaaag ccttaaaaac caaactggac ttgtcttcct 2400 tggcctattc cggaaaagat gcttgattct aggatgggtg gcatccctgt gacccctccc 2460 cagtgcctct cctggccctg gaagttgcca ctccagtgcc caccagcctt gtcctaataa 2520 aattaagttg catcattttg tctgactagg tgtccttcta taatattatg gggtggaggg 2580 gggtggtatg gagcaagggg caagttggga agacaacctg tagggcctgc ggggtctatt 2640 gggaaccaag ctggagtgca gtggcacaat cttggctcac tgcaatctcc gcctcctggg 2700 ttcaagcgat tctcctgcct cagcctcccg agttgttggg attccaggca tgcatgacca 2760 ggctcagcta atttttgttt ttttggtaga gacggggttt caccatattg gccaggctgg 2820 tctccaactc ctaatctcag gtgatctacc caccttggcc tcccaaattg ctgggattac 2880 aggcgtgaac cactgctccc ttccctgtcc ttagatctgt gtaataaagg aaatttattt 2940 tcattgcaat agtgtgttgg aattttttgt gtctctcata agtttttgta tgaatatgca 3000 agaaggcatc ctgattactc tgtcttgctg ctgctgagac ttgccaagac ctatgaaacc 3060 actctagaga agtgctgtgc ctctgcagat cctcatgaat gctatgccaa agtgttcagt 3120 gaatttaaac ctcttgtgga agagcctcag aatttaatca aacaaaattg tgagcttttt 3180 gagcagcttg gagagtacaa attccagaat gcactattag ttctttacac caagaaagta 3240 ccccaagtgt caactccaac tcttgtagag gtctcaagaa acctaggaaa agtgggcagc 3300 aaatgttgta aacatcctga agcaaaaaga atgccctgtg cagaagacta tctatccttg 3360 gtcctgaacc agttatgtgt gttgcatgag aaaacaccag taagtgacag agtcaccaaa 3420 tgctgcacag aatccttggt gaacaggcaa ccatgctttt cagctctgga agttgatgaa 3480 gttggttttg taagctttac cagatgagga acccctagtg atggagttgg ccactccctc 3540 tctgcgcgct cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt 3600 tgcccgggcg gcctcagtga gcgagcgagc gcgcagctgc ctgcagg 3647 <210> 56 <211> 4126 <212> ADN <213> Secuencia artificial <220> <223> Casete de transferencia de AAV <400> 56 cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc 60 gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca 120 actccatcac taggggttcc taacttgcat atgcatgcag agacacagtt tttgctctgg 180 tgaattacat cttctttaaa ggcaaatggg agagaccctt tgaagtcaag gacacagagg 240 aagaggactt cctagtggac caggtgacca ccttgaaggt gcctatgtaa aagcatttag 300 gcatgtttaa catccagcac tgtaagaagc tgtccagctg ggtgctgctg taaaaatacc 360 tgggcaatgc caccaccatc ttcttcctgc ctgatgaggg gaaactacag cacctggaaa 420 atgaactcac ccactatatt atcaccaagt tcctggaaaa tgaagacaga aggtctgcca 480 gcttacattt acccaaactg tcaattactg gaacctatga tctgaagagc ttcctgggtc 540 aactgggcat cactaaggtc ttcagcaatg gggctgacct ctcctgggtc acagaggagg 600 cacccctgaa gctctccaag gccttgcata aggctgtgct gaccatcaat aagaaaggta 660 aaatacagca tagcaaaact ttaacctcca aatcaagcct ctacttgaat ccttttctga 720 gggatgaata aggcataggc atcaggggct gttgccaatg tgcattagct gtttgcagcc 780 tcaccttctt tcatggagtt taagatatag tgtattttcc caaggtttga actagctctt 840 catttcttta tgttttaaat gcactgacct cccacattcc ctttttagta aaatattcag 900 aaataattta aatacatcat tgcaatgaaa ataaatgttt tttattaggc agaatccaga 960 tgctcaaggc ccttcataat atcccccagt ttagtagttg gacttaggga acaaaggaac 1020 ctttaataga aattggacag caagaaagcg agcagtactc agtgggctcc ggtgcccgtc 1080 agtgggcaga gcgcacatcg cccacagtcc ccgagaagtt ggggggaggg gtcggcaatt 1140 gaaccggtgc ctagagaagg tggcgcgggg taaactggga aagtgatgtc gtgtactggc 1200 tccgcctttt tcccgagggt gggggagaac cgtatataag tgcagtagtc gccgtgaacg 1260 ttctttttcg caacgggttt gccgccagaa cacaggtaag tgccgtgtgt ggttcccgcg 1320 ggcctggcct ctttacgggt tatggccctt gcgtgccttg aattacttcc acgcccctgg 1380 ctgcagtacg tgattcttga tcccgagctt cgggttggaa gtgggtggga gagttcgagg 1440 ccttgcgctt aaggagcccc ttcgcctcgt gcttgagttg aggcctggcc tgggcgctgg 1500 ggccgccgcg tgcgaatctg gtggcacctt cgcgcctgtc tcgctgcttt cgataagtct 1560 ctagccattt aaaatttttg atgacctgct gcgacgcttt ttttctggca agatagtctt 1620 gtaaatgcgg gccaagatct gcacactggt atttcggttt ttggggccgc gggcggcgac 1680 ggggcccgtg cgtcccagcg cacatgttcg gcgaggcggg gcctgcgagc gcggccaccg 1740 agaatcggac gggggtagtc tcaagctggc cggcctgctc tggtgcctgg cctcgcgccg 1800 ccgtgtatcg ccccgccctg ggcggcaagg ctggcccggt cggcaccagt tgcgtgagcg 1860 gaaagatggc cgcttcccgg ccctgctgca gggagctcaa aatggaggac gcggcgctcg 1920 ggagagcggg cgggtgagtc acccacacaa aggaaaaggg cctttccgtc ctcagccgtc 1980 gcttcatgtg actccacgga gtaccgggcg ccgtccaggc acctcgatta gttctcgagc 2040 ttttggagta cgtcgtcttt aggttggggg gaggggtttt atgcgatgga gtttccccac 2100 actgagtggg tggagactga agttaggcca gcttggcact tgatgtaatt ctccttggaa 2160 tttgcccttt ttgagtttgg atcttggttc attctcaagc ctcagacagt ggttcaaagt 2220 ttttttcttc catttcaggt gtcgtgacat agcggtacct acccggagca gcatgtggac 2280 tctcgggcgc cgcgcagtag ccggcctcct ggcgtcaccc agcccagccc aggcccagac 2340 cctcacccgg gtcccgcggc cggcagagtt ggccccactc tgcggccgcc gtggcctgcg 2400 caccgacatc gatgcgacct gcacgccccg ccgcgcaagt tcgaaccaac gtggcctcaa 2460 ccagatttgg aatgtcaaaa agcagagtgt ctatttgatg aatttgagga aatctggaac 2520 tttgggccac ccaggctctc tagatgagac cacctatgaa agactagcag aggaaacgct 2580 ggactcttta gcagagtttt ttgaagacct tgcagacaag ccatacacgt ttgaggacta 2640 tgatgtctcc tttgggagtg gtgtcttaac tgtcaaactg ggtggagatc taggaaccta 2700 tgtgatcaac aagcagacgc caaacaagca aatctggcta tcttctccat ccagtggacc 2760 taagcgttat gactggactg ggaaaaactg ggtgtactcc cacgacggcg tgtccctcca 2820 tgagctgctg gccgcagagc tcactaaagc cttaaaaacc aaactggact tgtcttcctt 2880 ggcctattcc ggaaaagatg cttgattcta ggatgggtgg catccctgtg acccctcccc 2940 agtgcctctc ctggccctgg aagttgccac tccagtgccc accagccttg tcctaataaa 3000 attaagttgc atcattttgt ctgactaggt gtccttctat aatattatgg ggtggagggg 3060 ggtggtatgg agcaaggggc aagttgggaa gacaacctgt agggcctgcg gggtctattg 3120 ggaaccaagc tggagtgcag tggcacaatc ttggctcact gcaatctccg cctcctgggt 3180 tcaagcgatt ctcctgcctc agcctcccga gttgttggga ttccaggcat gcatgaccag 3240 gctcagctaa tttttgtttt tttggtagag acggggtttc accatattgg ccaggctggt 3300 ctccaactcc taatctcagg tgatctaccc accttggcct cccaaattgc tgggattaca 3360 ggcgtgaacc actgctccct tccctgtcct tagatctgtg taataaagga aatttatttt 3420 cattgcaata gtgtgttgga attttttgtg tctctcataa gtttttgtat gaatatgcaa 3480 gaaggcatcc tgattactct gtcttgctgc tgctgagact tgccaagacc tatgaaacca 3540 ctctagagaa gtgctgtgcc tctgcagatc ctcatgaatg ctatgccaaa gtgttcagtg 3600 aatttaaacc tcttgtggaa gagcctcaga atttaatcaa acaaaattgt gagctttttg 3660 agcagcttgg agagtacaaa ttccagaatg cactattagt tctttacacc aagaaagtac 3720 cccaagtgtc aactccaact cttgtagagg tctcaagaaa cctaggaaaa gtgggcagca 3780 aatgttgtaa acatcctgaa gcaaaaagaa tgccctgtgc agaagactat ctatccttgg 3840 tcctgaacca gttatgtgtg ttgcatgaga aaacaccagt aagtgacaga gtcaccaaat 3900 gctgcacaga atccttggtg aacaggcaac catgcttttc agctctggaa gttgatgaag 3960 ttggttttgt aagctttacc agatgaggaa cccctagtga tggagttggc cactccctct 4020 ctgcgcgctc gctcgctcac tgaggccggg cgaccaaagg tcgcccgacg cccgggcttt 4080 gcccgggcgg cctcagtgag cgagcgagcg cgcagctgcc tgcagg 4126 <210> 57 <211> 3931 <212> ADN <213> Secuencia artificial <220> <223> Casete de transferencia de AAV <400> 57 cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc 60 gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca 120 actccatcac taggggttcc taacttgcat atgcatgcag agacacagtt tttgctctgg 180 tgaattacat cttctttaaa ggcaaatggg agagaccctt tgaagtcaag gacacagagg 240 aagaggactt cctagtggac caggtgacca ccttgaaggt gcctatgtaa aagcatttag 300 gcatgtttaa catccagcac tgtaagaagc tgtccagctg ggtgctgctg taaaaatacc 360 tgggcaatgc caccaccatc ttcttcctgc ctgatgaggg gaaactacag cacctggaaa 420 atgaactcac ccactatatt atcaccaagt tcctggaaaa tgaagacaga aggtctgcca 480 gcttacattt acccaaactg tcaattactg gaacctatga tctgaagagc ttcctgggtc 540 aactgggcat cactaaggtc ttcagcaatg gggctgacct ctcctgggtc acagaggagg 600 cacccctgaa gctctccaag gccttgcata aggctgtgct gaccatcaat aagaaaggta 660 aaatacagca tagcaaaact ttaacctcca aatcaagcct ctacttgaat ccttttctga 720 gggatgaata aggcataggc atcaggggct gttgccaatg tgcattagct gtttgcagcc 780 tcaccttctt tcatggagtt taagatatag tgtattttcc caaggtttga actagctctt 840 catttcttta tgttttaaat gcactgacct cccacattcc ctttttagta aaatattcag 900 aaataattta aatacatcat tgcaatgaaa ataaatgttt tttattaggc agaatccaga 960 tgctcaaggc ccttcataat atcccccagt ttagtagttg gacttaggga acaaaggaac 1020 ctttaataga aattggacag caagaaagcg agcagtactc agtggggggt tggggttgcg 1080 ccttttccaa ggcagccctg ggtttgcgca gggacgcggc tgctctgggc gtggttccgg 1140 gaaacgcagc ggcgccgacc ctgggtctcg cacattcttc acgtccgttc gcagcgtcac 1200 ccggatcttc gccgctaccc ttgtgggccc cccggcgacg cttcctgctc cgcccctaag 1260 tcgggaaggt tccttgcggt tcgcggcgtg ccggacgtga caaacggaag ccgcacgtct 1320 cactagtacc ctcgcagacg gacagcgcca gggagcaatg gcagcgcgcc gaccgcgatg 1380 ggctgtggcc aatagcggct gctcagcagg gcgcgccgag agcagcggcc gggaaggggc 1440 ggtgcgggag gcggggtgtg gggcggtagt gtgggccctg ttcctgcccg cgcggtgttc 1500 cgcattctgc aagcctccgg agcgcacgtc ggcagtcggc tccctcgttg accgaatcac 1560 cgacctctct ccccaggtga gtctatggga cccttgatgt tttctttccc cttcttttct 1620 atggttaagt tcatgtcata ggaaggggag aagtaacagg gtacacatat tgaccaaatc 1680 agggtaattt tgcatttgta attttaaaaa atgctttctt cttttaatat acttttttgt 1740 ttatcttatt tctaatactt tccctaatct ctttctttca gggcaataat gatacaatgt 1800 atcatgcctc tttgcaccat tctaaagaat aacagtgata atttctgggt taaggcaata 1860 gcaatatttc tgcatataaa tatttctgca tataaattgt aactgatgta agaggtttca 1920 tattgctaat agcagctaca atccagctac cattctgctt ttattttatg gttgggataa 1980 ggctggatta ttctgagtcc aagctaggcc cttttgctaa tcatgttcat acctcttatc 2040 ttcctcccac agcatagcgg tacctacccg gagcagcatg tggactctcg ggcgccgcgc 2100 agtagccggc ctcctggcgt cacccagccc agcccaggcc cagaccctca cccgggtccc 2160 gcggccggca gagttggccc cactctgcgg ccgccgtggc ctgcgcaccg acatcgatgc 2220 gacctgcacg ccccgccgcg caagttcgaa ccaacgtggc ctcaaccaga tttggaatgt 2280 caaaaagcag agtgtctatt tgatgaattt gaggaaatct ggaactttgg gccacccagg 2340 ctctctagat gagaccacct atgaaagact agcagaggaa acgctggact ctttagcaga 2400 gttttttgaa gaccttgcag acaagccata cacgtttgag gactatgatg tctcctttgg 2460 gagtggtgtc ttaactgtca aactgggtgg agatctagga acctatgtga tcaacaagca 2520 gacgccaaac aagcaaatct ggctatcttc tccatccagt ggacctaagc gttatgactg 2580 gactgggaaa aactgggtgt actcccacga cggcgtgtcc ctccatgagc tgctggccgc 2640 agagctcact aaagccttaa aaaccaaact ggacttgtct tccttggcct attccggaaa 2700 agatgcttga ttctaggatg ggtggcatcc ctgtgacccc tccccagtgc ctctcctggc 2760 cctggaagtt gccactccag tgcccaccag ccttgtccta ataaaattaa gttgcatcat 2820 tttgtctgac taggtgtcct tctataatat tatggggtgg aggggggtgg tatggagcaa 2880 ggggcaagtt gggaagacaa cctgtagggc ctgcggggtc tattgggaac caagctggag 2940 tgcagtggca caatcttggc tcactgcaat ctccgcctcc tgggttcaag cgattctcct 3000 gcctcagcct cccgagttgt tgggattcca ggcatgcatg accaggctca gctaattttt 3060 gtttttttgg tagagacggg gtttcaccat attggccagg ctggtctcca actcctaatc 3120 tcaggtgatc tacccacctt ggcctcccaa attgctggga ttacaggcgt gaaccactgc 3180 tcccttccct gtccttagat ctgtgtaata aaggaaattt attttcattg caatagtgtg 3240 ttggaatttt ttgtgtctct cataagtttt tgtatgaata tgcaagaagg catcctgatt 3300 actctgtctt gctgctgctg agacttgcca agacctatga aaccactcta gagaagtgct 3360 gtgcctctgc agatcctcat gaatgctatg ccaaagtgtt cagtgaattt aaacctcttg 3420 tggaagagcc tcagaattta atcaaacaaa attgtgagct ttttgagcag cttggagagt 3480 acaaattcca gaatgcacta ttagttcttt acaccaagaa agtaccccaa gtgtcaactc 3540 caactcttgt agaggtctca agaaacctag gaaaagtggg cagcaaatgt tgtaaacatc 3600 ctgaagcaaa aagaatgccc tgtgcagaag actatctatc cttggtcctg aaccagttat 3660 gtgtgttgca tgagaaaaca ccagtaagtg acagagtcac caaatgctgc acagaatcct 3720 tggtgaacag gcaaccatgc ttttcagctc tggaagttga tgaagttggt tttgtaagct 3780 ttaccagatg aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg 3840 ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca 3900 gtgagcgagc gagcgcgcag ctgcctgcag g 3931 <210> 58 <211> 3377 <212> ADN <213> Secuencia artificial <220> <223> Casete de transferencia de AAV <400> 58 cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc 60 gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca 120 actccatcac taggggttcc taacttgcat atgcatgcta aaatacagca tagcaaaact 180 ttaacctcca aatcaagcct ctacttgaat ccttttctga gggatgaata aggcataggc 240 atcaggggct gttgccaatg tgcattagct gtttgcagcc tcaccttctt tcatggagtt 300 taagatatag tgtattttcc caaggtttga actagctctt catttcttta tgttttaaat 360 gcactgacct cccacattcc ctttttagta aaatattcag aaataattta aatacatcat 420 tgcaatgaaa ataaatgttt tttattaggc agaatccaga tgctcaaggc ccttcataat 480 atcccccagt ttagtagttg gacttaggga acaaaggaac ctttaataga aattggacag 540 caagaaagcg agcagtactc agtgggcccg tcagtgggca gagcgcacat cgcccacagt 600 ccccgagaag ttggggggag gggtcggcaa ttgaaccggt gcctagagaa ggtggcgcgg 660 ggtaaactgg gaaagtgatg tcgtgtactg gctccgcctt tttcccgagg gtgggggaga 720 accgtatata agtgcagtag tcgccgtgaa cgttcttttt cgcaacgggt ttgccgccag 780 aacacgcgta agggagtcgc tgcgacgctg ccttcgcccc gtgccccgct ccgccgccgc 840 ctcgcgccgc ccgccccggc tctgactgac cgcgttactc ccacaggtga gcgggcggga 900 cggcccttct cctccgggct gtaattagcg cttggtttaa tgacggcttg tttcttttct 960 gtggctgcgt gaaagccttg aggggctccg ggagggccct ttgtgcgggg gggagcggct 1020 cggggggtgc gtgcgtgtgt gtgtgcgtgg ggagcgccgc gtgcggcccg cgctgcccgg 1080 cggctgtgag cgctgcgggc gcggcgcggg gctttgtgcg ctccgcagtg tgcgcgaggg 1140 gagcgcggcc gggggcggtg ccccgcggtg cggggggggc tgcgagggga acaaaggctg 1200 cgtgcggggt gtgtgcgtgg gggggtgagc agggggtatg ggcgcggcgg tcgggctgta 1260 acccccccct gcacccccct ccccgagttg ctgagcacgg cccggcttcg ggtgcggggc 1320 tccgtacggg gcgtggcgcg gggctcgccg tgccgggcgg ggggtggcgg caggtggggg 1380 tgccgggcgg ggcggggccg cctcgggccg gggagggctc gggggagggg cgcggcggcc 1440 cccggagcgc cggcggctgt cgaggcgcgg cgagccgcag ccattgcctt ttatggtaat 1500 cgtgcgagag ggcgcaggga cttactttgt cccaaatctg tgcggagccg aaatctggga 1560 ggcgccgccg caccccctct agcgggcgcg gggcgaagcg gtgcggcgcc ggcaggaagg 1620 aaatgggcgg ggagggcctt cgtgcgtcgc cgcgccgccg tccccttctc cctctccagc 1680 ctcggggctg tccgcggggg gacggctgcc ttcggggggg acggggcagg gcggggttcg 1740 gcttctggcg tgtgaccggc ggctctagag cctctgctaa ccatgttcat gccttcttct 1800 ttttcctaca gctcctgggc aacgtgctgg ttattgtgct gtctcatcat tttggcaaag 1860 aattctaaat agcggtacct acccggagca gcatgtggac tctcgggcgc cgcgcagtag 1920 ccggcctcct ggcgtcaccc agcccagccc aggcccagac cctcacccgg gtcccgcggc 1980 cggcagagtt ggccccactc tgcggccgcc gtggcctgcg caccgacatc gatgcgacct 2040 gcacgccccg ccgcgcaagt tcgaaccaac gtggcctcaa ccagatttgg aatgtcaaaa 2100 agcagagtgt ctatttgatg aatttgagga aatctggaac tttgggccac ccaggctctc 2160 tagatgagac cacctatgaa agactagcag aggaaacgct ggactcttta gcagagtttt 2220 ttgaagacct tgcagacaag ccatacacgt ttgaggacta tgatgtctcc tttgggagtg 2280 gtgtcttaac tgtcaaactg ggtggagatc taggaaccta tgtgatcaac aagcagacgc 2340 caaacaagca aatctggcta tcttctccat ccagtggacc taagcgttat gactggactg 2400 ggaaaaactg ggtgtactcc cacgacggcg tgtccctcca tgagctgctg gccgcagagc 2460 tcactaaagc cttaaaaacc aaactggact tgtcttcctt ggcctattcc ggaaaagatg 2520 cttgattcta ggatgggtgg catccctgtg acccctcccc agtgcctctc ctggccctgg 2580 aagttgccac tccagtgccc accagccttg tcctaataaa attaagttgc atcattttgt 2640 ctgactaggt gtccttctat aatattatgg ggtggagggg ggtggtatgg agcaaggggc 2700 aagttgggaa gacaacctgt agggcctgcg gggtctattg ggaaccaagc tggagtgcag 2760 tggcacaatc ttggctcact gcaatctccg cctcctgggt tcaagcgatt ctcctgcctc 2820 agcctcccga gttgttggga ttccaggcat gcatgaccag gctcagctaa tttttgtttt 2880 tttggtagag acggggtttc accatattgg ccaggctggt ctccaactcc taatctcagg 2940 tgatctaccc accttggcct cccaaattgc tgggattaca ggcgtgaacc actgctccct 3000 tccctgtcct tagatctgtg taataaagga aatttatttt cattgcaata gtgtgttgga 3060 attttttgtg tctctcagtt ggttgtaagt atcaaggtta caagacaggt ttaaggagac 3120 caatagaaac tgggcttgtc gagacagaga agactcttgc gtttctgata ggcacctatt 3180 ggtcttactg acatccactt tgcctttctc tccacagttg taagctttac cagatgagga 3240 acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca ctgaggccgg 3300 gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc 3360 gcgcagctgc ctgcagg 3377 <210> 59 <211> 2246 <212> ADN <213> Secuencia artificial <220> <223> Casete de transferencia de AAV <400> 59 cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc 60 gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca 120 actccatcac taggggttcc taacttgcat atgcatgggg cagagcgcac atcgcccaca 180 gtccccgaga agttgggggg aggggtcggc aattgaaccg gtgcctagag aaggtggcgc 240 ggggtaaact gggaaagtga tgtcgtgtac tggctccgcc tttttcccga gggtggggga 300 gaaccgtata taagtgcagt agtcgccgtg aacgttcttt ttcgcaacgg gtttgccgcc 360 agaacacgcc tcagtgagtc tatgggaccc ttgatgtttt ctttcccctt cttttctatg 420 gttaagttca tgtcatagga aggggagaag taacagggta cacatattga ccaaatcagg 480 gtaattttgc atttgtaatt ttaaaaaatg ctttcttctt ttaatatact tttttgttta 540 tcttatttct aatactttcc ctaatctctt tctttcaggg caataatgat acaatgtatc 600 atgcctcttt gcaccattct aaagaataac agtgataatt tctgggttaa ggcaatagca 660 atatttctgc atataaatat ttctgcatat aaattgtaac tgatgtaaga ggtttcatat 720 tgctaatagc agctacaatc cagctaccat tctgctttta ttttatggtt gggataaggc 780 tggattattc tgagtccaag ctaggccctt ttgctaatca tgttcatacc tcttatcttc 840 ctcccacagg gtacctaccc ggagcagcat gtggactctg gggaggagag cagtagctgg 900 cctcctggca tcacccagcc cagcccaggc ccagaccctc accagggtcc ctagaccagc 960 agagttggcc ccactctgtg gcaggagagg cctgaggaca gacattgatg ccacctgcac 1020 ccccaggaga gcaagttcca accaaagagg cctcaaccag atttggaatg tcaaaaagca 1080 gagtgtctat ttgatgaatt tgaggaaatc tggaactttg ggccacccag gctctctaga 1140 tgagaccacc tatgaaagac tagcagagga aacactggac tctttagcag agttttttga 1200 agaccttgca gacaagccat acacctttga ggactatgat gtctcctttg ggagtggtgt 1260 cttaactgtc aaactgggtg gagatctagg aacctatgtg atcaacaagc agactccaaa 1320 caagcaaatc tggctatctt ctccatccag tggacctaag aggtatgact ggactgggaa 1380 aaactgggtg tactcccatg atggagtgtc cctccatgag ctgctggctg cagagctcac 1440 taaagcctta aaaaccaaac tggacttgtc ttccttggcc tattctggaa aagatgcttg 1500 ataagtttaa acttctagga tgctcgcttt cttgctgtcc aatttctatt aaaggttcct 1560 ttgttcccta agtccaacta ctaaactggg ggatattatg aagggccttg agcatctgga 1620 ttctgcctaa taaaaaacat ttattttcat tgcaatgatg tatttaaatt atttctgaat 1680 attttactaa aaagggaatg tgggaggtca gtgcatttaa aacataaaga aatgaagagc 1740 tagttcaaac cttgggaaaa tacactatat cttaaactcc atgaaagaag gtgaggctgc 1800 aaacagctaa tgcacattgg caacagcccc tgatgcctat gccttattca tccctcagaa 1860 aaggattcaa gtagaggctt gatttggagg ttaaagtttt gctatgctgt attttaagat 1920 ctgtgtaata aaggaaattt attttcattg caatagtgtg ttggaatttt ttgtgtctct 1980 cagttggttg taagtatcaa ggttacaaga caggtttaag gagaccaata gaaactgggc 2040 ttgtcgagac agagaagact cttgcgtttc tgataggcac ctattggtct tactgacatc 2100 cactttgcct ttctctccac agtaagcttt accccactcc ctctctgcgc gctcgctcgc 2160 tcactgaggc cgggcgacca aaggtcgccc gacgcccggg ctttgcccgg gcggcctcag 2220 tgagcgagcg agcgcgcaga gaggga 2246 <210> 60 <211> 2165 <212> ADN <213> Secuencia artificial <220> <223> Casete de transferencia de AAV <400> 60 cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc 60 gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca 120 actccatcac taggggttcc taacttgcat atgcatgggg cagagcgcac atcgcccaca 180 gtccccgaga agttgggggg aggggtcggc aattgaaccg gtgcctagag aaggtggcgc 240 ggggtaaact gggaaagtga tgtcgtgtac tggctccgcc tttttcccga gggtggggga 300 gaaccgtata taagtgcagt agtcgccgtg aacgttcttt ttcgcaacgg gtttgccgcc 360 agaacacgcc tcagtgagtc tatgggaccc ttgatgtttt ctttcccctt cttttctatg 420 gttaagttca tgtcatagga aggggagaag taacagggta cacatattga ccaaatcagg 480 gtaattttgc atttgtaatt ttaaaaaatg ctttcttctt ttaatatact tttttgttta 540 tcttatttct aatactttcc ctaatctctt tctttcaggg caataatgat acaatgtatc 600 atgcctcttt gcaccattct aaagaataac agtgataatt tctgggttaa ggcaatagca 660 atatttctgc atataaatat ttctgcatat aaattgtaac tgatgtaaga ggtttcatat 720 tgctaatagc agctacaatc cagctaccat tctgctttta ttttatggtt gggataaggc 780 tggattattc tgagtccaag ctaggccctt ttgctaatca tgttcatacc tcttatcttc 840 ctcccacagg gtacctaccc ggagcagcat gtggactctg gggaggagag cagtagctgg 900 cctcctggca tcacccagcc cagcccaggc ccagaccctc accagggtcc ctagaccagc 960 agagttggcc ccactctgtg gcaggagagg cctgaggaca gacattgatg ccacctgcac 1020 ccccaggaga gcaagttcca accaaagagg cctcaaccag atttggaatg tcaaaaagca 1080 gagtgtctat ttgatgaatt tgaggaaatc tggaactttg ggccacccag gctctctaga 1140 tgagaccacc tatgaaagac tagcagagga aacactggac tctttagcag agttttttga 1200 agaccttgca gacaagccat acacctttga ggactatgat gtctcctttg ggagtggtgt 1260 cttaactgtc aaactgggtg gagatctagg aacctatgtg atcaacaagc agactccaaa 1320 caagcaaatc tggctatctt ctccatccag tggacctaag aggtatgact ggactgggaa 1380 aaactgggtg tactcccatg atggagtgtc cctccatgag ctgctggctg cagagctcac 1440 taaagcctta aaaaccaaac tggacttgtc ttccttggcc tattctggaa aagatgcttg 1500 ataacgactg caggtaggtt taaacaagct tggtaccgtg attaatcttc gaatgactga 1560 cgggtggcat ccctgtgacc cctccccagt gcctctcctg gccctggaag ttgccactcc 1620 agtgcccacc agccttgtcc taataaaatt aagttgcatc attttgtctg actaggtgtc 1680 cttctataat attatggggt ggaggggggt ggtatggagc aaggggcaag ttgggaagac 1740 aacctgtagg gcctgcgggg tctattggga accaagctgg agtgcagtgg cacaatcttg 1800 gctcactgca atctccgcct cctgggttca agcgattctc ctgcctcagc ctcccgagtt 1860 gttgggattc caggcatgca tgaccaggct cagctaattt ttgttttttt ggtagagacg 1920 gggtttcacc atattggcca ggctggtctc caactcctaa tctcaggtga tctacccacc 1980 ttggcctccc aaattgctgg gattacaggc gtgaaccact gctcccttcc ctgtccttag 2040 ataagcttta ccccactccc tctctgcgcg ctcgctcgct cactgaggcc gggcgaccaa 2100 aggtcgcccg acgcccgggc tttgcccggg cggcctcagt gagcgagcga gcgcgcagag 2160 aggga 2165 <210> 61 <211> 2071 <212> ADN <213> Secuencia artificial <220> <223> Casete de transferencia de AAV <400> 61 cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc 60 gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca 120 actccatcac taggggttcc ttgtgttgac agacctccta ggaggactgc ttgtatgcat 180 gcttttgcta agtactcaag aggttctggt gcccgtcagt gggcagagcg cacatcgccc 240 acagtccccg agaagttggg gggaggggtc ggcaattgaa ccggtgccta gagaaggtgg 300 cgcggggtaa actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg 360 ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc 420 gccagaacac gcgtaagggc taattccagc acactggctg ctgttactag agccatgcat 480 agtgaacctt cagatagaca tccagcctct ggactctagt gatcaggtac tagaggaact 540 gaaaaaccag aaagttcatg taagtatcaa ggttacaaga caggtttaag gagaccaata 600 gaaactgggc ttgtcgagac agagaagact cttgcgtttc tgataggcac ctattggtct 660 tactgacatc cactttgcct ttctctccac agtactggta cccggagcag catgtggact 720 ctcgggcgcc gcgcagtagc cggcctcctg gcgtcaccca gcccagccca ggcccagacc 780 ctcacccggg tcccgcggcc ggcagagttg gccccactct gcggccgccg tggcctgcgc 840 accgacatcg atgcgacctg cacgccccgc cgcgcaagtt cgaaccaacg tggcctcaac 900 cagatttgga atgtcaaaaa gcagagtgtc tatttgatga atttgaggaa atctggaact 960 ttgggccacc caggctctct agatgagacc acctatgaaa gactagcaga ggaaacgctg 1020 gactctttag cagagttttt tgaagacctt gcagacaagc catacacgtt tgaggactat 1080 gatgtctcct ttgggagtgg tgtcttaact gtcaaactgg gtggagatct aggaacctat 1140 gtgatcaaca agcagacgcc aaacaagcaa atctggctat cttctccatc cagtggacct 1200 aagcgttatg actggactgg gaaaaactgg gtgtactccc acgacggcgt gtccctccat 1260 gagctgctgg ccgcagagct cactaaagcc ttaaaaacca aactggactt gtcttccttg 1320 gcctattccg gaaaagatgc ttgagatccg actgcaggta ggtttaaaca agcttggtac 1380 cgtgattaat cttcgaatga ctgacgggtg gcatccctgt gacccctccc cagtgcctct 1440 cctggccctg gaagttgcca ctccagtgcc caccagcctt gtcctaataa aattaagttg 1500 catcattttg tctgactagg tgtccttcta taatattatg gggtggaggg gggtggtatg 1560 gagcaagggg caagttggga agacaacctg tagggcctgc ggggtctatt gggaaccaag 1620 ctggagtgca gtggcacaat cttggctcac tgcaatctcc gcctcctggg ttcaagcgat 1680 tctcctgcct cagcctcccg agttgttggg attccaggca tgcatgacca ggctcagcta 1740 atttttgttt ttttggtaga gacggggttt caccatattg gccaggctgg tctccaactc 1800 ctaatctcag gtgatctacc caccttggcc tcccaaattg ctgggattac aggcgtgaac 1860 cactgctccc ttccctgtcc ttagatctgt gtgttggttt tttgtgtgag aacagaacta 1920 ccaggtttag aaccatgggc aagacataga tgactagtcc actccctctc tgcgcgctcg 1980 ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc 2040 ctcagtgagc gagcgagcgc gcagagaggg a 2071 <210> 62 <211> 2071 <212> ADN <213> Secuencia artificial <220> <223> Casete de transferencia de AAV <400> 62 cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc 60 gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca 120 actccatcac taggggttcc ttgtgttgac agacctccta ggaggactgc ttgtatgcat 180 gcttttgcta agtactcaag aggttctggt gcccgtcagt gggcagagcg cacatcgccc 240 acagtccccg agaagttggg gggaggggtc ggcaattgaa ccggtgccta gagaaggtgg 300 cgcggggtaa actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg 360 ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc 420 gccagaacac gcgtaagggc taattccagc acactggctg ctgttactag agccatgcat 480 agtgaacctt cagatagaca tccagcctct ggactctagt gatcaggtac tagaggaact 540 gaaaaaccag aaagttcatg taagtatcaa ggttacaaga caggtttaag gagaccaata 600 gaaactgggc ttgtcgagac agagaagact cttgcgtttc tgataggcac ctattggtct 660 tactgacatc cactttgcct ttctctccac agtactggta cccggagcag catgtggact 720 ctggggagga gagcagtagc tggcctcctg gcatcaccca gcccagccca ggcccagacc 780 ctcaccaggg tccctagacc agcagagttg gccccactct gtggcaggag aggcctgagg 840 acagacattg atgccacctg cacccccagg agagcaagtt ccaaccaaag aggcctcaac 900 cagatttgga atgtcaaaaa gcagagtgtc tatttgatga atttgaggaa atctggaact 960 ttgggccacc caggctctct agatgagacc acctatgaaa gactagcaga ggaaacactg 1020 gactctttag cagagttttt tgaagacctt gcagacaagc catacacctt tgaggactat 1080 gatgtctcct ttgggagtgg tgtcttaact gtcaaactgg gtggagatct aggaacctat 1140 gtgatcaaca agcagactcc aaacaagcaa atctggctat cttctccatc cagtggacct 1200 aagaggtatg actggactgg gaaaaactgg gtgtactccc atgatggagt gtccctccat 1260 gagctgctgg ctgcagagct cactaaagcc ttaaaaacca aactggactt gtcttccttg 1320 gcctattctg gaaaagatgc ttgagatccg actgcaggta ggtttaaaca agcttggtac 1380 cgtgattaat cttcgaatga ctgacgggtg gcatccctgt gacccctccc cagtgcctct 1440 cctggccctg gaagttgcca ctccagtgcc caccagcctt gtcctaataa aattaagttg 1500 catcattttg tctgactagg tgtccttcta taatattatg gggtggaggg gggtggtatg 1560 gagcaagggg caagttggga agacaacctg tagggcctgc ggggtctatt gggaaccaag 1620 ctggagtgca gtggcacaat cttggctcac tgcaatctcc gcctcctggg ttcaagcgat 1680 tctcctgcct cagcctcccg agttgttggg attccaggca tgcatgacca ggctcagcta 1740 atttttgttt ttttggtaga gacggggttt caccatattg gccaggctgg tctccaactc 1800 ctaatctcag gtgatctacc caccttggcc tcccaaattg ctgggattac aggcgtgaac 1860 cactgctccc ttccctgtcc ttagatctgt gtgttggttt tttgtgtgag aacagaacta 1920 ccaggtttag aaccatgggc aagacataga tgactagtcc actccctctc tgcgcgctcg 1980 ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc 2040 ctcagtgagc gagcgagcgc gcagagaggg a 2071 <210> 63 <211> 2072 <212> ADN <213> Secuencia artificial <220> <223> Casete de transferencia de AAV <400> 63 cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc 60 gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca 120 actccatcac taggggttcc ttgtgttgac agacctccta ggaggactgc ttgtatgcat 180 gcttttgcta agtactcaag aggttctggt gcccgtcagt gggcagagcg cacatcgccc 240 acagtccccg agaagttggg gggaggggtc ggcaattgaa ccggtgccta gagaaggtgg 300 cgcggggtaa actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg 360 ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc 420 gccagaacac gcgtaagggc taattccagc acactggctg ctgttactag agccatgcat 480 agtgaacctt cagatagaca tccagcctct ggactctagt gatcaggtac tagaggaact 540 gaaaaaccag aaagttcatg taagtatcaa ggttacaaga caggtttaag gagaccaata 600 gaaactgggc ttgtcgagac agagaagact cttgcgtttc tgataggcac ctattggtct 660 tactgacatc cactttgcct ttctctccac agtactggta cccacagcca ccatgtggac 720 tctcgggcgc cgcgcagtag ccggcctcct ggcgtcaccc agcccagccc aggcccagac 780 cctcacccgg gtcccgcggc cggcagagtt ggccccactc tgcggccgcc gtggcctgcg 840 caccgacatc gatgcgacct gcacgccccg ccgcgcaagt tcgaaccaac gtggcctcaa 900 ccagatttgg aatgtcaaaa agcagagtgt ctatttgatg aatttgagga aatctggaac 960 tttgggccac ccaggctctc tagatgagac cacctatgaa agactagcag aggaaacgct 1020 ggactcttta gcagagtttt ttgaagacct tgcagacaag ccatacacgt ttgaggacta 1080 tgatgtctcc tttgggagtg gtgtcttaac tgtcaaactg ggtggagatc taggaaccta 1140 tgtgatcaac aagcagacgc caaacaagca aatctggcta tcttctccat ccagtggacc 1200 taagcgttat gactggactg ggaaaaactg ggtgtactcc cacgacggcg tgtccctcca 1260 tgagctgctg gccgcagagc tcactaaagc cttaaaaacc aaactggact tgtcttcctt 1320 ggcctattcc ggaaaagatg cttgagatcc gactgcaggt aggtttaaac aagcttggta 1380 ccgtgattaa tcttcgaatg actgacgggt ggcatccctg tgacccctcc ccagtgcctc 1440 tcctggccct ggaagttgcc actccagtgc ccaccagcct tgtcctaata aaattaagtt 1500 gcatcatttt gtctgactag gtgtccttct ataatattat ggggtggagg ggggtggtat 1560 ggagcaaggg gcaagttggg aagacaacct gtagggcctg cggggtctat tgggaaccaa 1620 gctggagtgc agtggcacaa tcttggctca ctgcaatctc cgcctcctgg gttcaagcga 1680 ttctcctgcc tcagcctccc gagttgttgg gattccaggc atgcatgacc aggctcagct 1740 aatttttgtt tttttggtag agacggggtt tcaccatatt ggccaggctg gtctccaact 1800 cctaatctca ggtgatctac ccaccttggc ctcccaaatt gctgggatta caggcgtgaa 1860 ccactgctcc cttccctgtc cttagatctg tgtgttggtt ttttgtgtga gaacagaact 1920 accaggttta gaaccatggg caagacatag atgactagtc cactccctct ctgcgcgctc 1980 gctcgctcac tgaggccggg cgaccaaagg tcgcccgacg cccgggcttt gcccgggcgg 2040 cctcagtgag cgagcgagcg cgcagagagg ga 2072 <210> 64 <211> 2072 <212> ADN <213> Secuencia artificial <220> <223> Casete de transferencia de AAV <400> 64 cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc 60 gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca 120 actccatcac taggggttcc ttgtgttgac agacctccta ggaggactgc ttgtatgcat 180 gcttttgcta agtactcaag aggttctggt gcccgtcagt gggcagagcg cacatcgccc 240 acagtccccg agaagttggg gggaggggtc ggcaattgaa ccggtgccta gagaaggtgg 300 cgcggggtaa actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg 360 ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc 420 gccagaacac gcgtaagggc taattccagc acactggctg ctgttactag agccatgcat 480 agtgaacctt cagatagaca tccagcctct ggactctagt gatcaggtac tagaggaact 540 gaaaaaccag aaagttcatg taagtatcaa ggttacaaga caggtttaag gagaccaata 600 gaaactgggc ttgtcgagac agagaagact cttgcgtttc tgataggcac ctattggtct 660 tactgacatc cactttgcct ttctctccac agtactggta cccacagcca ccatgtggac 720 tctggggagg agagcagtag ctggcctcct ggcatcaccc agcccagccc aggcccagac 780 cctcaccagg gtccctagac cagcagagtt ggccccactc tgtggcagga gaggcctgag 840 gacagacatt gatgccacct gcacccccag gagagcaagt tccaaccaaa gaggcctcaa 900 ccagatttgg aatgtcaaaa agcagagtgt ctatttgatg aatttgagga aatctggaac 960 tttgggccac ccaggctctc tagatgagac cacctatgaa agactagcag aggaaacact 1020 ggactcttta gcagagtttt ttgaagacct tgcagacaag ccatacacct ttgaggacta 1080 tgatgtctcc tttgggagtg gtgtcttaac tgtcaaactg ggtggagatc taggaaccta 1140 tgtgatcaac aagcagactc caaacaagca aatctggcta tcttctccat ccagtggacc 1200 taagaggtat gactggactg ggaaaaactg ggtgtactcc catgatggag tgtccctcca 1260 tgagctgctg gctgcagagc tcactaaagc cttaaaaacc aaactggact tgtcttcctt 1320 ggcctattct ggaaaagatg cttgagatcc gactgcaggt aggtttaaac aagcttggta 1380 ccgtgattaa tcttcgaatg actgacgggt ggcatccctg tgacccctcc ccagtgcctc 1440 tcctggccct ggaagttgcc actccagtgc ccaccagcct tgtcctaata aaattaagtt 1500 gcatcatttt gtctgactag gtgtccttct ataatattat ggggtggagg ggggtggtat 1560 ggagcaaggg gcaagttggg aagacaacct gtagggcctg cggggtctat tgggaaccaa 1620 gctggagtgc agtggcacaa tcttggctca ctgcaatctc cgcctcctgg gttcaagcga 1680 ttctcctgcc tcagcctccc gagttgttgg gattccaggc atgcatgacc aggctcagct 1740 aatttttgtt tttttggtag agacggggtt tcaccatatt ggccaggctg gtctccaact 1800 cctaatctca ggtgatctac ccaccttggc ctcccaaatt gctgggatta caggcgtgaa 1860 ccactgctcc cttccctgtc cttagatctg tgtgttggtt ttttgtgtga gaacagaact 1920 accaggttta gaaccatggg caagacatag atgactagtc cactccctct ctgcgcgctc 1980 gctcgctcac tgaggccggg cgaccaaagg tcgcccgacg cccgggcttt gcccgggcgg 2040 cctcagtgag cgagcgagcg cgcagagagg ga 2072 <210> 65 <211> 210 <212> PRT <213> Homo sapiens <400> 65 Met Trp Thr Leu Gly Arg Arg Ala Val Ala Gly Leu Leu Ala Ser Pro 1 5 10 15 Ser Pro Ala Gln Ala Gln Thr Leu Thr Arg Val Pro Arg Pro Ala Glu 20 25 30 Leu Ala Pro Leu Cys Gly Arg Arg Gly Leu Arg Thr Asp Ile Asp Ala 35 40 45 Thr Cys Thr Pro Arg Arg Ala Ser Ser Asn Gln Arg Gly Leu Asn Gln 50 55 60 Ile Trp Asn Val Lys Lys Gln Ser Val Tyr Leu Met Asn Leu Arg Lys 65 70 75 80 Ser Gly Thr Leu Gly His Pro Gly Ser Leu Asp Glu Thr Thr Tyr Glu 85 90 95 Arg Leu Ala Glu Glu Thr Leu Asp Ser Leu Ala Glu Phe Phe Glu Asp 100 105 110 Leu Ala Asp Lys Pro Tyr Thr Phe Glu Asp Tyr Asp Val Ser Phe Gly 115 120 125 Ser Gly Val Leu Thr Val Lys Leu Gly Gly Asp Leu Gly Thr Tyr Val 130 135 140 Ile Asn Lys Gln Thr Pro Asn Lys Gln Ile Trp Leu Ser Ser Pro Ser 145 150 155 160 Ser Gly Pro Lys Arg Tyr Asp Trp Thr Gly Lys Asn Trp Val Tyr Ser 165 170 175 His Asp Gly Val Ser Leu His Glu Leu Leu Ala Ala Glu Leu Thr Lys 180 185 190 Ala Leu Lys Thr Lys Leu Asp Leu Ser Ser Leu Ala Tyr Ser Gly Lys 195 200 205 Asp Ala 210 <210> 66 <211> 7 <212> ADN <213> Secuencia artificial <220> <223> Secuencia de Kozak <400> 66 accatgg 7 <210> 67 <211> 13 <212> ADN <213> Secuencia artificial <220> <223> Secuencia de Kozak <400> 67 gccgccacca tgg 13 <210> 68 <211> 13 <212> ADN <213> Secuencia artificial <220> <223> Secuencia de Kozak <400> 68 gccgccgcca tgg 13 <210> 69 <211> 9 <212> ADN <213> Secuencia artificial <220> <223> Secuencia de Kozak <400> 69 ccaccatgg 9 <210> 70 <211> 8 <212> ADN <213> Secuencia artificial <220> <223> Secuencia de Kozak <400> 70 ccaccatg 8