LISTADO DE SECUENCIAS <110> INTELLIA THERAPEUTICS, INC. <120> LÍPIDOS CON AMINA MODIFICADOS <130> ILH-00525 <140> PCT/US2019/064663 <141> 2019-12-05 <150> 62/775,783 <151> 2018-12-05 <160> 7 <170> PatentIn versión 3.5 <210> 1 <211> 100 <212> ARN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 1 uuacagccac gucuacagca guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc 60 cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu 100 <210> 2 <211> 100 <212> ARN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 2 gacaagcacc agaaagacca guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc 60 cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu 100 <210> 3 <211> 4516 <212> ARN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 3 gggucccgca gucggcgucc agcggcucug cuuguucgug ugugugucgu ugcaggccuu 60 auucggaucc gccaccaugg acaagaagua cagcaucgga cuggacaucg gaacaaacag 120 cgucggaugg gcagucauca cagacgaaua caaggucccg agcaagaagu ucaagguccu 180 gggaaacaca gacagacaca gcaucaagaa gaaccugauc ggagcacugc uguucgacag 240 cggagaaaca gcagaagcaa caagacugaa gagaacagca agaagaagau acacaagaag 300 aaagaacaga aucugcuacc ugcaggaaau cuucagcaac gaaauggcaa aggucgacga 360 cagcuucuuc cacagacugg aagaaagcuu ccuggucgaa gaagacaaga agcacgaaag 420 acacccgauc uucggaaaca ucgucgacga agucgcauac cacgaaaagu acccgacaau 480 cuaccaccug agaaagaagc uggucgacag cacagacaag gcagaccuga gacugaucua 540 ccuggcacug gcacacauga ucaaguucag aggacacuuc cugaucgaag gagaccugaa 600 cccggacaac agcgacgucg acaagcuguu cauccagcug guccagacau acaaccagcu 660 guucgaagaa aacccgauca acgcaagcgg agucgacgca aaggcaaucc ugagcgcaag 720 acugagcaag agcagaagac uggaaaaccu gaucgcacag cugccgggag aaaagaagaa 780 cggacuguuc ggaaaccuga ucgcacugag ccugggacug acaccgaacu ucaagagcaa 840 cuucgaccug gcagaagacg caaagcugca gcugagcaag gacacauacg acgacgaccu 900 ggacaaccug cuggcacaga ucggagacca guacgcagac cuguuccugg cagcaaagaa 960 ccugagcgac gcaauccugc ugagcgacau ccugagaguc aacacagaaa ucacaaaggc 1020 accgcugagc gcaagcauga ucaagagaua cgacgaacac caccaggacc ugacacugcu 1080 gaaggcacug gucagacagc agcugccgga aaaguacaag gaaaucuucu ucgaccagag 1140 caagaacgga uacgcaggau acaucgacgg aggagcaagc caggaagaau ucuacaaguu 1200 caucaagccg auccuggaaa agauggacgg aacagaagaa cugcugguca agcugaacag 1260 agaagaccug cugagaaagc agagaacauu cgacaacgga agcaucccgc accagaucca 1320 ccugggagaa cugcacgcaa uccugagaag acaggaagac uucuacccgu uccugaagga 1380 caacagagaa aagaucgaaa agauccugac auucagaauc ccguacuacg ucggaccgcu 1440 ggcaagagga aacagcagau ucgcauggau gacaagaaag agcgaagaaa caaucacacc 1500 guggaacuuc gaagaagucg ucgacaaggg agcaagcgca cagagcuuca ucgaaagaau 1560 gacaaacuuc gacaagaacc ugccgaacga aaagguccug ccgaagcaca gccugcugua 1620 cgaauacuuc acagucuaca acgaacugac aaaggucaag uacgucacag aaggaaugag 1680 aaagccggca uuccugagcg gagaacagaa gaaggcaauc gucgaccugc uguucaagac 1740 aaacagaaag gucacaguca agcagcugaa ggaagacuac uucaagaaga ucgaaugcuu 1800 cgacagcguc gaaaucagcg gagucgaaga cagauucaac gcaagccugg gaacauacca 1860 cgaccugcug aagaucauca aggacaagga cuuccuggac aacgaagaaa acgaagacau 1920 ccuggaagac aucguccuga cacugacacu guucgaagac agagaaauga ucgaagaaag 1980 acugaagaca uacgcacacc uguucgacga caaggucaug aagcagcuga agagaagaag 2040 auacacagga uggggaagac ugagcagaaa gcugaucaac ggaaucagag acaagcagag 2100 cggaaagaca auccuggacu uccugaagag cgacggauuc gcaaacagaa acuucaugca 2160 gcugauccac gacgacagcc ugacauucaa ggaagacauc cagaaggcac aggucagcgg 2220 acagggagac agccugcacg aacacaucgc aaaccuggca ggaagcccgg caaucaagaa 2280 gggaauccug cagacaguca aggucgucga cgaacugguc aaggucaugg gaagacacaa 2340 gccggaaaac aucgucaucg aaauggcaag agaaaaccag acaacacaga agggacagaa 2400 gaacagcaga gaaagaauga agagaaucga agaaggaauc aaggaacugg gaagccagau 2460 ccugaaggaa cacccggucg aaaacacaca gcugcagaac gaaaagcugu accuguacua 2520 ccugcagaac ggaagagaca uguacgucga ccaggaacug gacaucaaca gacugagcga 2580 cuacgacguc gaccacaucg ucccgcagag cuuccugaag gacgacagca ucgacaacaa 2640 gguccugaca agaagcgaca agaacagagg aaagagcgac aacgucccga gcgaagaagu 2700 cgucaagaag augaagaacu acuggagaca gcugcugaac gcaaagcuga ucacacagag 2760 aaaguucgac aaccugacaa aggcagagag aggaggacug agcgaacugg acaaggcagg 2820 auucaucaag agacagcugg ucgaaacaag acagaucaca aagcacgucg cacagauccu 2880 ggacagcaga augaacacaa aguacgacga aaacgacaag cugaucagag aagucaaggu 2940 caucacacug aagagcaagc uggucagcga cuucagaaag gacuuccagu ucuacaaggu 3000 cagagaaauc aacaacuacc accacgcaca cgacgcauac cugaacgcag ucgucggaac 3060 agcacugauc aagaaguacc cgaagcugga aagcgaauuc gucuacggag acuacaaggu 3120 cuacgacguc agaaagauga ucgcaaagag cgaacaggaa aucggaaagg caacagcaaa 3180 guacuucuuc uacagcaaca ucaugaacuu cuucaagaca gaaaucacac uggcaaacgg 3240 agaaaucaga aagagaccgc ugaucgaaac aaacggagaa acaggagaaa ucgucuggga 3300 caagggaaga gacuucgcaa cagucagaaa gguccugagc augccgcagg ucaacaucgu 3360 caagaagaca gaaguccaga caggaggauu cagcaaggaa agcauccugc cgaagagaaa 3420 cagcgacaag cugaucgcaa gaaagaagga cugggacccg aagaaguacg gaggauucga 3480 cagcccgaca gucgcauaca gcguccuggu cgucgcaaag gucgaaaagg gaaagagcaa 3540 gaagcugaag agcgucaagg aacugcuggg aaucacaauc auggaaagaa gcagcuucga 3600 aaagaacccg aucgacuucc uggaagcaaa gggauacaag gaagucaaga aggaccugau 3660 caucaagcug ccgaaguaca gccuguucga acuggaaaac ggaagaaaga gaaugcuggc 3720 aagcgcagga gaacugcaga agggaaacga acuggcacug ccgagcaagu acgucaacuu 3780 ccuguaccug gcaagccacu acgaaaagcu gaagggaagc ccggaagaca acgaacagaa 3840 gcagcuguuc gucgaacagc acaagcacua ccuggacgaa aucaucgaac agaucagcga 3900 auucagcaag agagucaucc uggcagacgc aaaccuggac aagguccuga gcgcauacaa 3960 caagcacaga gacaagccga ucagagaaca ggcagaaaac aucauccacc uguucacacu 4020 gacaaaccug ggagcaccgg cagcauucaa guacuucgac acaacaaucg acagaaagag 4080 auacacaagc acaaaggaag uccuggacgc aacacugauc caccagagca ucacaggacu 4140 guacgaaaca agaaucgacc ugagccagcu gggaggagac ggaggaggaa gcccgaagaa 4200 gaagagaaag gucuagcuag ccaucacauu uaaaagcauc ucagccuacc augagaauaa 4260 gagaaagaaa augaagauca auagcuuauu caucucuuuu ucuuuuucgu ugguguaaag 4320 ccaacacccu gucuaaaaaa cauaaauuuc uuuaaucauu uugccucuuu ucucugugcu 4380 ucaauuaaua aaaaauggaa agaaccucga gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 4440 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 4500 aaaaaaaaaa aucuag 4516 <210> 4 <211> 100 <212> ARN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 4 acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc 60 cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu 100 <210> 5 <211> 100 <212> ARN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 5 acgcaaauau caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc 60 cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu 100 <210> 6 <211> 100 <212> ADN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 6 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 60 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 100 <210> 7 <211> 100 <212> ADN <213> Secuencia artificial <220> <221> fuente <223> /nota="Descripción de secuencia artificial: Polinucleótido sintético" <400> 7 tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt 60 tttttttttt tttttttttt tttttttttt tttttttttt 100