LISTADO DE SECUENCIAS <110> MEMORIAL SLOAN KETTERING CANCER CENTER TRI-INSTITUTIONAL THERAPEUTICS DISCOVERY INSTITUTE <120> ANTICUERPOS DIRIGIDOS CONTRA DLL3 Y USOS DE LOS MISMOS <130> 115872-0910 <140> PCT/US2020/041282 <141> 08/07/2020 <150> 62/872.915 <151> 11/07/2019 <160> 59 <170> PatentIn versión 3.5 <210> 1 <211> 357 <212> ADN <213> Secuencia artificial <220> <223> Descripción de la secuencia artificial: Polinucleótido sintético <400> 1 gaggtgcagc tggtggagtc tggggggggc ttggtaaagc ctggggggtc ccttagactc 60 tcctgtgcag cctctggatt cactttcagt aacacctgga tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggttggccgt attaaaagca aatctgatgg tgggacaaca 180 gactacgctg cacccgtgaa aggcagattc accatctcaa gagatgattc aaaaaacacg 240 ctgtatctgc aaatgaacag cctgaaaacc gaggacacag ccgtgtatta ctgtacccag 300 tattattgga actcctttga ctactggggc cagggaaccc tggtcaccgt ctcctca 357 <210> 2 <211> 119 <212> PRT <213> Secuencia artificial <220> <223> Descripción de la secuencia artificial: Polipéptido sintético <400> 2 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Thr 20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Arg Ile Lys Ser Lys Ser Asp Gly Gly Thr Thr Asp Tyr Ala Ala 50 55 60 Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Thr Gln Tyr Tyr Trp Asn Ser Phe Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 3 <211> 8 <212> PRT <213> Secuencia artificial <220> <223> Descripción de la secuencia artificial: Péptido sintético <400> 3 Gly Phe Thr Phe Ser Asn Thr Trp 1 5 <210> 4 <211> 10 <212> PRT <213> Secuencia artificial <220> <223> Descripción de la secuencia artificial: Péptido sintético <400> 4 Ile Lys Ser Lys Ser Asp Gly Gly Thr Thr 1 5 10 <210> 5 <211> 10 <212> PRT <213> Secuencia artificial <220> <223> Descripción de la secuencia artificial: Péptido sintético <400> 5 Thr Gln Tyr Tyr Trp Asn Ser Phe Asp Tyr 1 5 10 <210> 6 <211> 321 <212> ADN <213> Secuencia artificial <220> <223> Descripción de la secuencia artificial: Polinucleótido sintético <400> 6 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc aggcgagtca ggacattagc aactatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctacgat gcatccaatt tggaaacagg ggtcccatca 180 aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct 240 gaagatattg caacatatta ctgtcaacag tatgataatc tcccgctcac tttcggcgga 300 gggaccaagg tggagatcaa a 321 <210> 7 <211> 107 <212> PRT <213> Secuencia artificial <220> <223> Descripción de la secuencia artificial: Polipéptido sintético <400> 7 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 8 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> Descripción de la secuencia artificial: Péptido sintético <400> 8 Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 9 <211> 7 <212> PRT <213> Secuencia artificial <220> <223> Descripción de la secuencia artificial: Péptido sintético <400> 9 Asp Ala Ser Asn Leu Glu Thr 1 5 <210> 10 <211> 9 <212> PRT <213> Secuencia artificial <220> <223> Descripción de la secuencia artificial: Péptido sintético <400> 10 Gln Gln Tyr Asp Asn Leu Pro Leu Thr 1 5 <210> 11 <211> 354 <212> ADN <213> Secuencia artificial <220> <223> Descripción de la secuencia artificial: Polinucleótido sintético <400> 11 gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc ccagagactc 60 tcctgtgcag cctctggatt cacctttagt agctattgga tgaactgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtggccaac ataaaggaag atggaagtga gaaatactat 180 gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat 240 ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagatccg 300 ggctgggctc cctttgacta ctggggccag ggaaccctgg tcaccgtctc ctca 354 <210> 12 <211> 118 <212> PRT <213> Secuencia artificial <220> <223> Descripción de la secuencia artificial: Polipéptido sintético <400> 12 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Gln Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Asn Ile Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Pro Gly Trp Ala Pro Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 13 <211> 7 <212> PRT <213> Secuencia artificial <220> <223> Descripción de la secuencia artificial: Péptido sintético <400> 13 Gly Phe Thr Phe Ser Ser Tyr 1 5 <210> 14 <211> 6 <212> PRT <213> Secuencia artificial <220> <223> Descripción de la secuencia artificial: Péptido sintético <400> 14 Lys Glu Asp Gly Ser Glu 1 5 <210> 15 <211> 9 <212> PRT <213> Secuencia artificial <220> <223> Descripción de la secuencia artificial: Péptido sintético <400> 15 Asp Pro Gly Trp Ala Pro Phe Asp Tyr 1 5 <210> 16 <211> 321 <212> ADN <213> Secuencia artificial <220> <223> Descripción de la secuencia artificial: Polinucleótido sintético <400> 16 gacatccaga tgtcccagtc tccatcctca ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgtc gggcgagtca gggcattagc aattatttag cctggtttca gcagaaacca 120 gggaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180 aagttcagcg gcagtggatc tgggacagat ttcactctcg ccatcagcag cctgcagcct 240 gaagattttg caacttatta ctgccaacag tataatagtt tcccgtacac ttttggccag 300 gggaccacgc tggagatcaa a 321 <210> 17 <211> 107 <212> PRT <213> Secuencia artificial <220> <223> Descripción de la secuencia artificial: Polipéptido sintético <400> 17 Asp Ile Gln Met Ser Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 20 25 30 Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Lys Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Ala Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Phe Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Thr Leu Glu Ile Lys 100 105 <210> 18 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> Descripción de la secuencia artificial: Péptido sintético <400> 18 Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Ala 1 5 10 <210> 19 <211> 7 <212> PRT <213> Secuencia artificial <220> <223> Descripción de la secuencia artificial: Péptido sintético <400> 19 Ala Ala Ser Ser Leu Gln Ser 1 5 <210> 20 <211> 9 <212> PRT <213> Secuencia artificial <220> <223> Descripción de la secuencia artificial: Péptido sintético <400> 20 Gln Gln Tyr Asn Ser Phe Pro Tyr Thr 1 5 <210> 21 <211> 354 <212> ADN <213> Secuencia artificial <220> <223> Descripción de la secuencia artificial: Polinucleótido sintético <400> 21 caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcaat agttactact ggagctggat ccggcagccc 120 ccagggaagg gactggagtg gattgggtat atcttttaca gtgggatcac caactacaac 180 ccctccctca agagtcgagt caccatatca ttagacacgt ccaagaacca gttctccctg 240 aagctgagct ctgtgaccgc tgcggacacg gccgtgtatt actgtgcgag aatcggcgtg 300 gctggttttt actttgacta ctggggccag ggaaccctgg tcaccgtctc ctca 354 <210> 22 <211> 118 <212> PRT <213> Secuencia artificial <220> <223> Descripción de la secuencia artificial: Polipéptido sintético <400> 22 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Asn Ser Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Phe Tyr Ser Gly Ile Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Leu Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Ile Gly Val Ala Gly Phe Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 23 <211> 7 <212> PRT <213> Secuencia artificial <220> <223> Descripción de la secuencia artificial: Péptido sintético <400> 23 Gly Gly Ser Ile Asn Ser Tyr 1 5 <210> 24 <211> 5 <212> PRT <213> Secuencia artificial <220> <223> Descripción de la secuencia artificial: Péptido sintético <400> 24 Phe Tyr Ser Gly Ile 1 5 <210> 25 <211> 10 <212> PRT <213> Secuencia artificial <220> <223> Descripción de la secuencia artificial: Péptido sintético <400> 25 Ile Gly Val Ala Gly Phe Tyr Phe Asp Tyr 1 5 10 <210> 26 <211> 324 <212> ADN <213> Secuencia artificial <220> <223> Descripción de la secuencia artificial: Polinucleótido sintético <400> 26 gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagtatggta cctcaccgct cactttcggc 300 ggagggacca aggtggagat caaa 324 <210> 27 <211> 108 <212> PRT <213> Secuencia artificial <220> <223> Descripción de la secuencia artificial: Polipéptido sintético <400> 27 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Thr Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 28 <211> 12 <212> PRT <213> Secuencia artificial <220> <223> Descripción de la secuencia artificial: Péptido sintético <400> 28 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 29 <211> 7 <212> PRT <213> Secuencia artificial <220> <223> Descripción de la secuencia artificial: Péptido sintético <400> 29 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 30 <211> 9 <212> PRT <213> Secuencia artificial <220> <223> Descripción de la secuencia artificial: Péptido sintético <400> 30 Gln Gln Tyr Gly Thr Ser Pro Leu Thr 1 5 <210> 31 <211> 360 <212> ADN <213> Secuencia artificial <220> <223> Descripción de la secuencia artificial: Polinucleótido sintético <400> 31 caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt 60 tcctgcaagg catctggata caccttcacc agctactata tacactgggt gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaata atcgacccaa gtgatggtag cacaaactac 180 gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac 240 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagatcgg 300 gaatataact actacggttt ggacgtctgg ggccaaggga ccacggtcac cgtctcctca 360 <210> 32 <211> 120 <212> PRT <213> Secuencia artificial <220> <223> Descripción de la secuencia artificial: Polipéptido sintético <400> 32 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asp Pro Ser Asp Gly Ser Thr Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Arg Glu Tyr Asn Tyr Tyr Gly Leu Asp Val Trp Gly Gln 100 105 110 Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 33 <211> 7 <212> PRT <213> Secuencia artificial <220> <223> Descripción de la secuencia artificial: Péptido sintético <400> 33 Gly Tyr Thr Phe Thr Ser Tyr 1 5 <210> 34 <211> 6 <212> PRT <213> Secuencia artificial <220> <223> Descripción de la secuencia artificial: Péptido sintético <400> 34 Asp Pro Ser Asp Gly Ser 1 5 <210> 35 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> Descripción de la secuencia artificial: Péptido sintético <400> 35 Asp Arg Glu Tyr Asn Tyr Tyr Gly Leu Asp Val 1 5 10 <210> 36 <211> 336 <212> ADN <213> Secuencia artificial <220> <223> Descripción de la secuencia artificial: Polinucleótido sintético <400> 36 gatgttgtga tgactcagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc 60 atctcctgca ggtctagtca aagcctcgta taccgtgatg gaaacaccta cttgaattgg 120 tttcagcaga ggccaggcca atctccaagg cgcctaattt ataaggtttc taaccgggac 180 tctggggtcc cagacagatt ccgcggcagt gggtcaggca ctgatttcac actgaaaatc 240 agccgggtgg aggctgagga tgttggggtt tattactgca tgcaaggtac acactggcct 300 ccgacgttcg gccaagggac caaggtggaa atcaaa 336 <210> 37 <211> 112 <212> PRT <213> Secuencia artificial <220> <223> Descripción de la secuencia artificial: Polipéptido sintético <400> 37 Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 1 5 10 15 Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Arg 20 25 30 Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 35 40 45 Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 50 55 60 Asp Arg Phe Arg Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 85 90 95 Thr His Trp Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 38 <211> 16 <212> PRT <213> Secuencia artificial <220> <223> Descripción de la secuencia artificial: Péptido sintético <400> 38 Arg Ser Ser Gln Ser Leu Val Tyr Arg Asp Gly Asn Thr Tyr Leu Asn 1 5 10 15 <210> 39 <211> 7 <212> PRT <213> Secuencia artificial <220> <223> Descripción de la secuencia artificial: Péptido sintético <400> 39 Lys Val Ser Asn Arg Asp Ser 1 5 <210> 40 <211> 9 <212> PRT <213> Secuencia artificial <220> <223> Descripción de la secuencia artificial: Péptido sintético <400> 40 Met Gln Gly Thr His Trp Pro Pro Thr 1 5 <210> 41 <211> 384 <212> PRT <213> Homo sapiens <400> 41 Ala Pro Thr Lys Ala Pro Asp Val Phe Pro Ile Ile Ser Gly Cys Arg 1 5 10 15 His Pro Lys Asp Asn Ser Pro Val Val Leu Ala Cys Leu Ile Thr Gly 20 25 30 Tyr His Pro Thr Ser Val Thr Val Thr Trp Tyr Met Gly Thr Gln Ser 35 40 45 Gln Pro Gln Arg Thr Phe Pro Glu Ile Gln Arg Arg Asp Ser Tyr Tyr 50 55 60 Met Thr Ser Ser Gln Leu Ser Thr Pro Leu Gln Gln Trp Arg Gln Gly 65 70 75 80 Glu Tyr Lys Cys Val Val Gln His Thr Ala Ser Lys Ser Lys Lys Glu 85 90 95 Ile Phe Arg Trp Pro Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro 100 105 110 Thr Ala Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala 115 120 125 Pro Ala Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys 130 135 140 Glu Lys Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu 145 150 155 160 Cys Pro Ser His Thr Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro Ala 165 170 175 Val Gln Asp Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe Val 180 185 190 Val Gly Ser Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala Gly 195 200 205 Lys Val Pro Thr Gly Gly Val Glu Glu Gly Leu Leu Glu Arg His Ser 210 215 220 Asn Gly Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser Leu 225 230 235 240 Trp Asn Ala Gly Thr Ser Val Thr Cys Thr Leu Asn His Pro Ser Leu 245 250 255 Pro Pro Gln Arg Leu Met Ala Leu Arg Glu Pro Ala Ala Gln Ala Pro 260 265 270 Val Lys Leu Ser Leu Asn Leu Leu Ala Ser Ser Asp Pro Pro Glu Ala 275 280 285 Ala Ser Trp Leu Leu Cys Glu Val Ser Gly Phe Ser Pro Pro Asn Ile 290 295 300 Leu Leu Met Trp Leu Glu Asp Gln Arg Glu Val Asn Thr Ser Gly Phe 305 310 315 320 Ala Pro Ala Arg Pro Pro Pro Gln Pro Gly Ser Thr Thr Phe Trp Ala 325 330 335 Trp Ser Val Leu Arg Val Pro Ala Pro Pro Ser Pro Gln Pro Ala Thr 340 345 350 Tyr Thr Cys Val Val Ser His Glu Asp Ser Arg Thr Leu Leu Asn Ala 355 360 365 Ser Arg Ser Leu Glu Val Ser Tyr Val Thr Asp His Gly Pro Met Lys 370 375 380 <210> 42 <211> 330 <212> PRT <213> Homo sapiens <400> 42 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 1 5 10 15 Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 65 70 75 80 Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 100 105 110 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 115 120 125 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 130 135 140 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 145 150 155 160 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 165 170 175 Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 180 185 190 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 195 200 205 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 210 215 220 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 225 230 235 240 Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 245 250 255 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 260 265 270 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 275 280 285 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 290 295 300 Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 305 310 315 320 Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 325 330 <210> 43 <211> 326 <212> PRT <213> Homo sapiens <400> 43 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 1 5 10 15 Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 65 70 75 80 Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 100 105 110 Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 115 120 125 Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 130 135 140 Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 145 150 155 160 Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 165 170 175 Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 180 185 190 Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 195 200 205 Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 210 215 220 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 225 230 235 240 Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 245 250 255 Ser Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 260 265 270 Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 275 280 285 Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 290 295 300 Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 305 310 315 320 Ser Leu Ser Pro Gly Lys 325 <210> 44 <211> 377 <212> PRT <213> Homo sapiens <400> 44 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 1 5 10 15 Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 65 70 75 80 Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro 100 105 110 Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 115 120 125 Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 130 135 140 Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 145 150 155 160 Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 165 170 175 Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 180 185 190 Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 195 200 205 Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 210 215 220 Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 225 230 235 240 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 245 250 255 Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 260 265 270 Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 275 280 285 Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 290 295 300 Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn 305 310 315 320 Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 325 330 335 Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile 340 345 350 Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln 355 360 365 Lys Ser Leu Ser Leu Ser Pro Gly Lys 370 375 <210> 45 <211> 452 <212> PRT <213> Homo sapiens <400> 45 Gly Ser Ala Ser Ala Pro Thr Leu Phe Pro Leu Val Ser Cys Glu Asn 1 5 10 15 Ser Pro Ser Asp Thr Ser Ser Val Ala Val Gly Cys Leu Ala Gln Asp 20 25 30 Phe Leu Pro Asp Ser Ile Thr Leu Ser Trp Lys Tyr Lys Asn Asn Ser 35 40 45 Asp Ile Ser Ser Thr Arg Gly Phe Pro Ser Val Leu Arg Gly Gly Lys 50 55 60 Tyr Ala Ala Thr Ser Gln Val Leu Leu Pro Ser Lys Asp Val Met Gln 65 70 75 80 Gly Thr Asp Glu His Val Val Cys Lys Val Gln His Pro Asn Gly Asn 85 90 95 Lys Glu Lys Asn Val Pro Leu Pro Val Ile Ala Glu Leu Pro Pro Lys 100 105 110 Val Ser Val Phe Val Pro Pro Arg Asp Gly Phe Phe Gly Asn Pro Arg 115 120 125 Lys Ser Lys Leu Ile Cys Gln Ala Thr Gly Phe Ser Pro Arg Gln Ile 130 135 140 Gln Val Ser Trp Leu Arg Glu Gly Lys Gln Val Gly Ser Gly Val Thr 145 150 155 160 Thr Asp Gln Val Gln Ala Glu Ala Lys Glu Ser Gly Pro Thr Thr Tyr 165 170 175 Lys Val Thr Ser Thr Leu Thr Ile Lys Glu Ser Asp Trp Leu Gly Gln 180 185 190 Ser Met Phe Thr Cys Arg Val Asp His Arg Gly Leu Thr Phe Gln Gln 195 200 205 Asn Ala Ser Ser Met Cys Val Pro Asp Gln Asp Thr Ala Ile Arg Val 210 215 220 Phe Ala Ile Pro Pro Ser Phe Ala Ser Ile Phe Leu Thr Lys Ser Thr 225 230 235 240 Lys Leu Thr Cys Leu Val Thr Asp Leu Thr Thr Tyr Asp Ser Val Thr 245 250 255 Ile Ser Trp Thr Arg Gln Asn Gly Glu Ala Val Lys Thr His Thr Asn 260 265 270 Ile Ser Glu Ser His Pro Asn Ala Thr Phe Ser Ala Val Gly Glu Ala 275 280 285 Ser Ile Cys Glu Asp Asp Trp Asn Ser Gly Glu Arg Phe Thr Cys Thr 290 295 300 Val Thr His Thr Asp Leu Pro Ser Pro Leu Lys Gln Thr Ile Ser Arg 305 310 315 320 Pro Lys Gly Val Ala Leu His Arg Pro Asp Val Tyr Leu Leu Pro Pro 325 330 335 Ala Arg Glu Gln Leu Asn Leu Arg Glu Ser Ala Thr Ile Thr Cys Leu 340 345 350 Val Thr Gly Phe Ser Pro Ala Asp Val Phe Val Gln Trp Met Gln Arg 355 360 365 Gly Gln Pro Leu Ser Pro Glu Lys Tyr Val Thr Ser Ala Pro Met Pro 370 375 380 Glu Pro Gln Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val 385 390 395 400 Ser Glu Glu Glu Trp Asn Thr Gly Glu Thr Tyr Thr Cys Val Ala His 405 410 415 Glu Ala Leu Pro Asn Arg Val Thr Glu Arg Thr Val Asp Lys Ser Thr 420 425 430 Gly Lys Pro Thr Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala 435 440 445 Gly Thr Cys Tyr 450 <210> 46 <211> 327 <212> PRT <213> Homo sapiens <400> 46 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 1 5 10 15 Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 65 70 75 80 Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 100 105 110 Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 115 120 125 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 130 135 140 Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 145 150 155 160 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 165 170 175 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 180 185 190 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 195 200 205 Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 210 215 220 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 225 230 235 240 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 245 250 255 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 260 265 270 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 275 280 285 Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 290 295 300 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 305 310 315 320 Leu Ser Leu Ser Leu Gly Lys 325 <210> 47 <211> 353 <212> PRT <213> Homo sapiens <400> 47 Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Cys Ser Thr 1 5 10 15 Gln Pro Asp Gly Asn Val Val Ile Ala Cys Leu Val Gln Gly Phe Phe 20 25 30 Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Gly Val 35 40 45 Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 50 55 60 Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Leu Ala Gly 65 70 75 80 Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp 85 90 95 Val Thr Val Pro Cys Pro Val Pro Ser Thr Pro Pro Thr Pro Ser Pro 100 105 110 Ser Thr Pro Pro Thr Pro Ser Pro Ser Cys Cys His Pro Arg Leu Ser 115 120 125 Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn 130 135 140 Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Val Thr Phe 145 150 155 160 Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu 165 170 175 Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Cys 180 185 190 Ala Glu Pro Trp Asn His Gly Lys Thr Phe Thr Cys Thr Ala Ala Tyr 195 200 205 Pro Glu Ser Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn 210 215 220 Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu 225 230 235 240 Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser 245 250 255 Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro 260 265 270 Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly 275 280 285 Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala Glu Asp 290 295 300 Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu 305 310 315 320 Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly Lys Pro 325 330 335 Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr Cys 340 345 350 Tyr <210> 48 <211> 340 <212> PRT <213> Homo sapiens <400> 48 Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Asp Ser Thr 1 5 10 15 Pro Gln Asp Gly Asn Val Val Val Ala Cys Leu Val Gln Gly Phe Phe 20 25 30 Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Asn Val 35 40 45 Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 50 55 60 Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Pro Asp Gly 65 70 75 80 Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp 85 90 95 Val Thr Val Pro Cys Pro Val Pro Pro Pro Pro Pro Cys Cys His Pro 100 105 110 Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser 115 120 125 Glu Ala Asn Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly 130 135 140 Ala Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly 145 150 155 160 Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu 165 170 175 Pro Gly Cys Ala Gln Pro Trp Asn His Gly Glu Thr Phe Thr Cys Thr 180 185 190 Ala Ala His Pro Glu Leu Lys Thr Pro Leu Thr Ala Asn Ile Thr Lys 195 200 205 Ser Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser 210 215 220 Glu Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg 225 230 235 240 Gly Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln 245 250 255 Glu Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro 260 265 270 Ser Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala 275 280 285 Ala Glu Asp Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His 290 295 300 Glu Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Met Ala 305 310 315 320 Gly Lys Pro Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp 325 330 335 Gly Thr Cys Tyr 340 <210> 49 <211> 106 <212> PRT <213> Homo sapiens <400> 49 Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 1 5 10 15 Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 20 25 30 Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 35 40 45 Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 50 55 60 Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 65 70 75 80 His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 85 90 95 Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 100 105 <210> 50 <211> 618 <212> PRT <213> Homo sapiens <400> 50 Met Val Ser Pro Arg Met Ser Gly Leu Leu Ser Gln Thr Val Ile Leu 1 5 10 15 Ala Leu Ile Phe Leu Pro Gln Thr Arg Pro Ala Gly Val Phe Glu Leu 20 25 30 Gln Ile His Ser Phe Gly Pro Gly Pro Gly Pro Gly Ala Pro Arg Ser 35 40 45 Pro Cys Ser Ala Arg Leu Pro Cys Arg Leu Phe Phe Arg Val Cys Leu 50 55 60 Lys Pro Gly Leu Ser Glu Glu Ala Ala Glu Ser Pro Cys Ala Leu Gly 65 70 75 80 Ala Ala Leu Ser Ala Arg Gly Pro Val Tyr Thr Glu Gln Pro Gly Ala 85 90 95 Pro Ala Pro Asp Leu Pro Leu Pro Asp Gly Leu Leu Gln Val Pro Phe 100 105 110 Arg Asp Ala Trp Pro Gly Thr Phe Ser Phe Ile Ile Glu Thr Trp Arg 115 120 125 Glu Glu Leu Gly Asp Gln Ile Gly Gly Pro Ala Trp Ser Leu Leu Ala 130 135 140 Arg Val Ala Gly Arg Arg Arg Leu Ala Ala Gly Gly Pro Trp Ala Arg 145 150 155 160 Asp Ile Gln Arg Ala Gly Ala Trp Glu Leu Arg Phe Ser Tyr Arg Ala 165 170 175 Arg Cys Glu Pro Pro Ala Val Gly Thr Ala Cys Thr Arg Leu Cys Arg 180 185 190 Pro Arg Ser Ala Pro Ser Arg Cys Gly Pro Gly Leu Arg Pro Cys Ala 195 200 205 Pro Leu Glu Asp Glu Cys Glu Ala Pro Leu Val Cys Arg Ala Gly Cys 210 215 220 Ser Pro Glu His Gly Phe Cys Glu Gln Pro Gly Glu Cys Arg Cys Leu 225 230 235 240 Glu Gly Trp Thr Gly Pro Leu Cys Thr Val Pro Val Ser Thr Ser Ser 245 250 255 Cys Leu Ser Pro Arg Gly Pro Ser Ser Ala Thr Thr Gly Cys Leu Val 260 265 270 Pro Gly Pro Gly Pro Cys Asp Gly Asn Pro Cys Ala Asn Gly Gly Ser 275 280 285 Cys Ser Glu Thr Pro Arg Ser Phe Glu Cys Thr Cys Pro Arg Gly Phe 290 295 300 Tyr Gly Leu Arg Cys Glu Val Ser Gly Val Thr Cys Ala Asp Gly Pro 305 310 315 320 Cys Phe Asn Gly Gly Leu Cys Val Gly Gly Ala Asp Pro Asp Ser Ala 325 330 335 Tyr Ile Cys His Cys Pro Pro Gly Phe Gln Gly Ser Asn Cys Glu Lys 340 345 350 Arg Val Asp Arg Cys Ser Leu Gln Pro Cys Arg Asn Gly Gly Leu Cys 355 360 365 Leu Asp Leu Gly His Ala Leu Arg Cys Arg Cys Arg Ala Gly Phe Ala 370 375 380 Gly Pro Arg Cys Glu His Asp Leu Asp Asp Cys Ala Gly Arg Ala Cys 385 390 395 400 Ala Asn Gly Gly Thr Cys Val Glu Gly Gly Gly Ala His Arg Cys Ser 405 410 415 Cys Ala Leu Gly Phe Gly Gly Arg Asp Cys Arg Glu Arg Ala Asp Pro 420 425 430 Cys Ala Ala Arg Pro Cys Ala His Gly Gly Arg Cys Tyr Ala His Phe 435 440 445 Ser Gly Leu Val Cys Ala Cys Ala Pro Gly Tyr Met Gly Ala Arg Cys 450 455 460 Glu Phe Pro Val His Pro Asp Gly Ala Ser Ala Leu Pro Ala Ala Pro 465 470 475 480 Pro Gly Leu Arg Pro Gly Asp Pro Gln Arg Tyr Leu Leu Pro Pro Ala 485 490 495 Leu Gly Leu Leu Val Ala Ala Gly Val Ala Gly Ala Ala Leu Leu Leu 500 505 510 Val His Val Arg Arg Arg Gly His Ser Gln Asp Ala Gly Ser Arg Leu 515 520 525 Leu Ala Gly Thr Pro Glu Pro Ser Val His Ala Leu Pro Asp Ala Leu 530 535 540 Asn Asn Leu Arg Thr Gln Glu Gly Ser Gly Asp Gly Pro Ser Ser Ser 545 550 555 560 Val Asp Trp Asn Arg Pro Glu Asp Val Asp Pro Gln Gly Ile Tyr Val 565 570 575 Ile Ser Ala Pro Ser Ile Tyr Ala Arg Glu Val Ala Thr Pro Leu Phe 580 585 590 Pro Pro Leu His Thr Gly Arg Ala Gly Gln Arg Gln His Leu Leu Phe 595 600 605 Pro Tyr Pro Ser Ser Ile Leu Ser Val Lys 610 615 <210> 51 <211> 587 <212> PRT <213> Homo sapiens <400> 51 Met Val Ser Pro Arg Met Ser Gly Leu Leu Ser Gln Thr Val Ile Leu 1 5 10 15 Ala Leu Ile Phe Leu Pro Gln Thr Arg Pro Ala Gly Val Phe Glu Leu 20 25 30 Gln Ile His Ser Phe Gly Pro Gly Pro Gly Pro Gly Ala Pro Arg Ser 35 40 45 Pro Cys Ser Ala Arg Leu Pro Cys Arg Leu Phe Phe Arg Val Cys Leu 50 55 60 Lys Pro Gly Leu Ser Glu Glu Ala Ala Glu Ser Pro Cys Ala Leu Gly 65 70 75 80 Ala Ala Leu Ser Ala Arg Gly Pro Val Tyr Thr Glu Gln Pro Gly Ala 85 90 95 Pro Ala Pro Asp Leu Pro Leu Pro Asp Gly Leu Leu Gln Val Pro Phe 100 105 110 Arg Asp Ala Trp Pro Gly Thr Phe Ser Phe Ile Ile Glu Thr Trp Arg 115 120 125 Glu Glu Leu Gly Asp Gln Ile Gly Gly Pro Ala Trp Ser Leu Leu Ala 130 135 140 Arg Val Ala Gly Arg Arg Arg Leu Ala Ala Gly Gly Pro Trp Ala Arg 145 150 155 160 Asp Ile Gln Arg Ala Gly Ala Trp Glu Leu Arg Phe Ser Tyr Arg Ala 165 170 175 Arg Cys Glu Pro Pro Ala Val Gly Thr Ala Cys Thr Arg Leu Cys Arg 180 185 190 Pro Arg Ser Ala Pro Ser Arg Cys Gly Pro Gly Leu Arg Pro Cys Ala 195 200 205 Pro Leu Glu Asp Glu Cys Glu Ala Pro Leu Val Cys Arg Ala Gly Cys 210 215 220 Ser Pro Glu His Gly Phe Cys Glu Gln Pro Gly Glu Cys Arg Cys Leu 225 230 235 240 Glu Gly Trp Thr Gly Pro Leu Cys Thr Val Pro Val Ser Thr Ser Ser 245 250 255 Cys Leu Ser Pro Arg Gly Pro Ser Ser Ala Thr Thr Gly Cys Leu Val 260 265 270 Pro Gly Pro Gly Pro Cys Asp Gly Asn Pro Cys Ala Asn Gly Gly Ser 275 280 285 Cys Ser Glu Thr Pro Arg Ser Phe Glu Cys Thr Cys Pro Arg Gly Phe 290 295 300 Tyr Gly Leu Arg Cys Glu Val Ser Gly Val Thr Cys Ala Asp Gly Pro 305 310 315 320 Cys Phe Asn Gly Gly Leu Cys Val Gly Gly Ala Asp Pro Asp Ser Ala 325 330 335 Tyr Ile Cys His Cys Pro Pro Gly Phe Gln Gly Ser Asn Cys Glu Lys 340 345 350 Arg Val Asp Arg Cys Ser Leu Gln Pro Cys Arg Asn Gly Gly Leu Cys 355 360 365 Leu Asp Leu Gly His Ala Leu Arg Cys Arg Cys Arg Ala Gly Phe Ala 370 375 380 Gly Pro Arg Cys Glu His Asp Leu Asp Asp Cys Ala Gly Arg Ala Cys 385 390 395 400 Ala Asn Gly Gly Thr Cys Val Glu Gly Gly Gly Ala His Arg Cys Ser 405 410 415 Cys Ala Leu Gly Phe Gly Gly Arg Asp Cys Arg Glu Arg Ala Asp Pro 420 425 430 Cys Ala Ala Arg Pro Cys Ala His Gly Gly Arg Cys Tyr Ala His Phe 435 440 445 Ser Gly Leu Val Cys Ala Cys Ala Pro Gly Tyr Met Gly Ala Arg Cys 450 455 460 Glu Phe Pro Val His Pro Asp Gly Ala Ser Ala Leu Pro Ala Ala Pro 465 470 475 480 Pro Gly Leu Arg Pro Gly Asp Pro Gln Arg Tyr Leu Leu Pro Pro Ala 485 490 495 Leu Gly Leu Leu Val Ala Ala Gly Val Ala Gly Ala Ala Leu Leu Leu 500 505 510 Val His Val Arg Arg Arg Gly His Ser Gln Asp Ala Gly Ser Arg Leu 515 520 525 Leu Ala Gly Thr Pro Glu Pro Ser Val His Ala Leu Pro Asp Ala Leu 530 535 540 Asn Asn Leu Arg Thr Gln Glu Gly Ser Gly Asp Gly Pro Ser Ser Ser 545 550 555 560 Val Asp Trp Asn Arg Pro Glu Asp Val Asp Pro Gln Gly Ile Tyr Val 565 570 575 Ile Ser Ala Pro Ser Ile Tyr Ala Arg Glu Ala 580 585 <210> 52 <211> 587 <212> PRT <213> Pan troglodytes <400> 52 Met Val Ser Pro Arg Met Ser Arg Leu Leu Ser Gln Thr Val Ile Leu 1 5 10 15 Ala Leu Ile Phe Leu Pro Gln Thr Arg Pro Ala Gly Val Phe Glu Leu 20 25 30 Gln Ile His Ser Phe Gly Pro Gly Pro Gly Pro Gly Ala Pro Arg Ser 35 40 45 Pro Cys Ser Ala Arg Val Pro Cys Arg Leu Phe Phe Arg Val Cys Leu 50 55 60 Lys Pro Gly Leu Ser Glu Glu Ala Ala Glu Ser Pro Cys Ala Leu Gly 65 70 75 80 Ala Ala Leu Ser Ala Arg Gly Pro Val Tyr Thr Glu Gln Pro Gly Ala 85 90 95 Pro Ala Pro Asp Leu Pro Leu Pro Asp Gly Leu Leu Gln Val Pro Phe 100 105 110 Arg Asp Ala Trp Pro Gly Thr Phe Ser Phe Ile Ile Glu Thr Trp Arg 115 120 125 Glu Glu Leu Gly Asp Gln Ile Gly Gly Pro Ala Trp Ser Leu Leu Ala 130 135 140 Arg Val Ala Gly Arg Arg Arg Leu Ala Ala Gly Gly Thr Trp Ala Arg 145 150 155 160 Asp Ile Gln Arg Ala Gly Ala Trp Glu Leu Arg Phe Ser Tyr Arg Ala 165 170 175 Arg Cys Glu Pro Pro Ala Val Gly Thr Ala Cys Thr Arg Leu Cys Arg 180 185 190 Pro Arg Ser Ala Pro Ser Arg Cys Gly Pro Gly Leu Arg Pro Cys Ala 195 200 205 Pro Leu Glu Asp Glu Cys Glu Ala Pro Pro Val Cys Arg Ala Gly Cys 210 215 220 Ser Pro Glu His Gly Phe Cys Glu Gln Pro Gly Glu Cys Arg Cys Leu 225 230 235 240 Glu Gly Trp Thr Gly Pro Leu Cys Thr Val Pro Val Ser Thr Ser Ser 245 250 255 Cys Leu Ser Pro Arg Gly Pro Ser Ser Ala Thr Thr Gly Cys Leu Val 260 265 270 Pro Gly Pro Gly Pro Cys Asp Gly Asn Pro Cys Ala Asn Gly Gly Ser 275 280 285 Cys Ser Glu Thr Pro Gly Ser Phe Glu Cys Ala Cys Pro Arg Gly Phe 290 295 300 Tyr Gly Leu Arg Cys Glu Val Ser Gly Val Thr Cys Ala Asp Gly Pro 305 310 315 320 Cys Phe Asn Gly Gly Leu Cys Val Gly Gly Ala Asp Pro Asp Ser Ala 325 330 335 Tyr Ile Cys His Cys Pro Pro Gly Phe Gln Gly Ser Asn Cys Glu Lys 340 345 350 Arg Val Asp Arg Cys Ser Leu Gln Pro Cys Arg Asn Gly Gly Leu Cys 355 360 365 Leu Asp Leu Gly His Ala Leu Arg Cys Arg Cys Arg Ala Gly Phe Ala 370 375 380 Gly Pro Arg Cys Glu His Asp Leu Asp Asp Cys Ala Gly Arg Ala Cys 385 390 395 400 Ala Asn Gly Gly Thr Cys Val Glu Gly Gly Gly Ala His Arg Cys Ser 405 410 415 Cys Ala Leu Gly Phe Gly Gly Arg Asp Cys Arg Glu Arg Ala Asp Pro 420 425 430 Cys Ala Ala Arg Pro Cys Ala His Gly Gly Arg Cys Tyr Ala His Phe 435 440 445 Ser Gly Leu Val Cys Ala Cys Ala Pro Gly Tyr Met Gly Ala Arg Cys 450 455 460 Glu Phe Pro Val His Pro Asp Gly Ala Ser Ala Leu Pro Ala Ala Pro 465 470 475 480 Pro Gly Leu Arg Pro Gly Asp Pro Gln Arg Tyr Leu Leu Pro Pro Ala 485 490 495 Leu Gly Leu Leu Val Ala Ala Gly Val Ala Gly Ala Ala Leu Leu Leu 500 505 510 Val His Val Arg Arg Arg Gly His Ala Gln Asp Ala Gly Ala Arg Leu 515 520 525 Leu Ala Gly Thr Pro Glu Pro Ser Val His Ala Leu Pro Asp Ala Leu 530 535 540 Asn Asn Leu Arg Thr Gln Glu Gly Ala Gly Asp Gly Pro Ser Ser Ser 545 550 555 560 Val Asp Trp Asn Arg Pro Glu Asp Val Asp Pro Arg Gly Ile Tyr Val 565 570 575 Ile Ser Ala Pro Ser Ile Tyr Ala Arg Glu Ala 580 585 <210> 53 <211> 585 <212> PRT <213> Mus musculus <400> 53 Met Val Ser Leu Gln Val Ser Pro Leu Ser Gln Thr Leu Ile Leu Ala 1 5 10 15 Phe Leu Leu Pro Gln Ala Leu Pro Ala Gly Val Phe Glu Leu Gln Ile 20 25 30 His Ser Phe Gly Pro Gly Pro Gly Leu Gly Thr Pro Arg Ser Pro Cys 35 40 45 Asn Ala Arg Gly Pro Cys Arg Leu Phe Phe Arg Val Cys Leu Lys Pro 50 55 60 Gly Val Ser Gln Glu Ala Thr Glu Ser Leu Cys Ala Leu Gly Ala Ala 65 70 75 80 Leu Ser Thr Ser Val Pro Val Tyr Thr Glu His Pro Gly Glu Ser Ala 85 90 95 Ala Ala Leu Pro Leu Pro Asp Gly Leu Val Arg Val Pro Phe Arg Asp 100 105 110 Ala Trp Pro Gly Thr Phe Ser Leu Val Ile Glu Thr Trp Arg Glu Gln 115 120 125 Leu Gly Glu His Ala Gly Gly Pro Ala Trp Asn Leu Leu Ala Arg Val 130 135 140 Val Gly Arg Arg Arg Leu Ala Ala Gly Gly Pro Trp Ala Arg Asp Val 145 150 155 160 Gln Arg Thr Gly Thr Trp Glu Leu His Phe Ser Tyr Arg Ala Arg Cys 165 170 175 Glu Pro Pro Ala Val Gly Ala Ala Cys Ala Arg Leu Cys Arg Ser Arg 180 185 190 Ser Ala Pro Ser Arg Cys Gly Pro Gly Leu Arg Pro Cys Thr Pro Phe 195 200 205 Pro Asp Glu Cys Glu Ala Pro Ser Val Cys Arg Pro Gly Cys Ser Pro 210 215 220 Glu His Gly Tyr Cys Glu Glu Pro Asp Glu Cys Arg Cys Leu Glu Gly 225 230 235 240 Trp Thr Gly Pro Leu Cys Thr Val Pro Val Ser Thr Ser Ser Cys Leu 245 250 255 Asn Ser Arg Val Pro Gly Pro Ala Ser Thr Gly Cys Leu Leu Pro Gly 260 265 270 Pro Gly Pro Cys Asp Gly Asn Pro Cys Ala Asn Gly Gly Ser Cys Ser 275 280 285 Glu Thr Ser Gly Ser Phe Glu Cys Ala Cys Pro Arg Gly Phe Tyr Gly 290 295 300 Leu Arg Cys Glu Val Ser Gly Val Thr Cys Ala Asp Gly Pro Cys Phe 305 310 315 320 Asn Gly Gly Leu Cys Val Gly Gly Glu Asp Pro Asp Ser Ala Tyr Val 325 330 335 Cys His Cys Pro Pro Gly Phe Gln Gly Ser Asn Cys Glu Lys Arg Val 340 345 350 Asp Arg Cys Ser Leu Gln Pro Cys Gln Asn Gly Gly Leu Cys Leu Asp 355 360 365 Leu Gly His Ala Leu Arg Cys Arg Cys Arg Ala Gly Phe Ala Gly Pro 370 375 380 Arg Cys Glu His Asp Leu Asp Asp Cys Ala Gly Arg Ala Cys Ala Asn 385 390 395 400 Gly Gly Thr Cys Val Glu Gly Gly Gly Ser Arg Arg Cys Ser Cys Ala 405 410 415 Leu Gly Phe Gly Gly Arg Asp Cys Arg Glu Arg Ala Asp Pro Cys Ala 420 425 430 Ser Arg Pro Cys Ala His Gly Gly Arg Cys Tyr Ala His Phe Ser Gly 435 440 445 Leu Val Cys Ala Cys Ala Pro Gly Tyr Met Gly Val Arg Cys Glu Phe 450 455 460 Ala Val Arg Pro Asp Gly Ala Asp Ala Val Pro Ala Ala Pro Arg Gly 465 470 475 480 Leu Arg Gln Ala Asp Pro Gln Arg Phe Leu Leu Pro Pro Ala Leu Gly 485 490 495 Leu Leu Val Ala Ala Gly Leu Ala Gly Ala Ala Leu Leu Val Ile His 500 505 510 Val Arg Arg Arg Gly Pro Gly Gln Asp Thr Gly Thr Arg Leu Leu Ser 515 520 525 Gly Thr Arg Glu Pro Ser Val His Thr Leu Pro Asp Ala Leu Asn Asn 530 535 540 Leu Arg Leu Gln Asp Gly Ala Gly Asp Gly Pro Ser Ser Ser Ala Asp 545 550 555 560 Trp Asn His Pro Glu Asp Gly Asp Ser Arg Ser Ile Tyr Val Ile Pro 565 570 575 Ala Pro Ser Ile Tyr Ala Arg Glu Ala 580 585 <210> 54 <211> 589 <212> PRT <213> Rattus norvegicus <400> 54 Met Val Ser Leu Gln Val Ser Ser Leu Pro Gln Thr Leu Ile Leu Ala 1 5 10 15 Phe Leu Leu Pro Gln Ala Leu Pro Ala Gly Val Phe Glu Leu Gln Ile 20 25 30 His Ser Phe Gly Pro Gly Pro Gly Pro Gly Thr Pro Arg Ser Pro Cys 35 40 45 Asn Ala Arg Gly Pro Cys Arg Leu Phe Phe Arg Val Cys Leu Lys Pro 50 55 60 Gly Val Ser Gln Glu Ala Ala Glu Ser Leu Cys Ala Leu Gly Ala Ala 65 70 75 80 Leu Ser Thr Ser Gly Pro Val Tyr Thr Glu Gln Pro Gly Val Pro Ala 85 90 95 Ala Ala Leu Ser Leu Pro Asp Gly Leu Val Arg Val Pro Phe Leu Asp 100 105 110 Ala Trp Pro Gly Thr Phe Ser Leu Ile Ile Glu Thr Trp Arg Glu Gln 115 120 125 Leu Gly Glu Arg Ala Ala Gly Pro Ala Trp Asn Leu Leu Ala Arg Val 130 135 140 Ala Gly Arg Arg Arg Leu Ala Ala Gly Ala Pro Trp Ala Arg Asp Val 145 150 155 160 Gln Arg Thr Gly Ala Trp Glu Leu His Phe Ser Tyr Arg Ala Arg Cys 165 170 175 Glu Pro Pro Ala Val Gly Ala Ala Cys Ala Arg Leu Cys Arg Ser Arg 180 185 190 Ser Ala Pro Ser Arg Cys Gly Pro Gly Leu Arg Pro Cys Thr Pro Phe 195 200 205 Pro Asp Glu Cys Glu Ala Pro Arg Glu Ser Leu Thr Val Cys Arg Ala 210 215 220 Gly Cys Ser Pro Glu His Gly Tyr Cys Glu Glu Pro Asp Glu Cys His 225 230 235 240 Cys Leu Glu Gly Trp Thr Gly Pro Leu Cys Thr Val Pro Val Ser Thr 245 250 255 Ser Ser Cys Leu Asn Ser Arg Val Ser Gly Pro Ala Gly Thr Gly Cys 260 265 270 Leu Leu Pro Gly Pro Gly Pro Cys Asp Gly Asn Pro Cys Ala Asn Gly 275 280 285 Gly Ser Cys Ser Glu Thr Pro Gly Ser Phe Glu Cys Ala Cys Pro Arg 290 295 300 Gly Phe Tyr Gly Pro Arg Cys Glu Val Ser Gly Val Thr Cys Ala Asp 305 310 315 320 Gly Pro Cys Phe Asn Gly Gly Leu Cys Val Gly Gly Glu Asp Pro Asp 325 330 335 Ser Ala Tyr Val Cys His Cys Pro Pro Ala Phe Gln Gly Ser Asn Cys 340 345 350 Glu Arg Arg Val Asp Arg Cys Ser Leu Gln Pro Cys Gln Asn Gly Gly 355 360 365 Leu Cys Leu Asp Leu Gly His Ala Leu Arg Cys Arg Cys Arg Ala Gly 370 375 380 Phe Ala Gly Pro Arg Cys Glu His Asp Leu Asp Asp Cys Ala Gly Arg 385 390 395 400 Ala Cys Ala Asn Gly Gly Thr Cys Val Glu Gly Gly Gly Ala Arg Arg 405 410 415 Cys Ser Cys Ala Leu Gly Phe Gly Gly Arg Asp Cys Arg Glu Arg Ala 420 425 430 Asp Pro Cys Ala Ser Arg Pro Cys Ala His Gly Gly Arg Cys Tyr Ala 435 440 445 His Phe Ser Gly Leu Val Cys Ala Cys Ala Pro Gly Tyr Met Gly Val 450 455 460 Arg Cys Glu Phe Ala Val Arg Pro Asp Gly Ala Asp Ala Val Pro Ala 465 470 475 480 Ala Pro Arg Gly Leu Arg Gln Ala Asp Ser Gln Arg Phe Leu Leu Pro 485 490 495 Pro Ala Leu Gly Leu Leu Ala Ala Ala Ala Leu Ala Gly Ala Ala Leu 500 505 510 Leu Leu Ile His Val Arg Arg Arg Gly Pro Gly Arg Asp Thr Gly Thr 515 520 525 Arg Leu Leu Ser Gly Thr Arg Glu Pro Ser Val His Thr Leu Pro Asp 530 535 540 Ala Leu Asn Asn Leu Arg Leu Gln Asp Gly Ala Gly Asp Gly Pro Thr 545 550 555 560 Ser Ser Ala Asp Trp Asn His Pro Glu Asp Gly Asp Ser Arg Ser Ile 565 570 575 Tyr Val Ile Pro Ala Pro Ser Ile Tyr Ala Arg Glu Ala 580 585 <210> 55 <211> 2341 <212> ADN <213> Homo sapiens <400> 55 actcccgaga cccccccacc agaaggccat ggtctcccca cggatgtccg ggctcctctc 60 ccagactgtg atcctagcgc tcattttcct cccccagaca cggcccgctg gcgtcttcga 120 gctgcagatc cactctttcg ggccgggtcc aggccctggg gccccgcggt ccccctgcag 180 cgcccggctc ccctgccgcc tcttcttcag agtctgcctg aagcctgggc tctcagagga 240 ggccgccgag tccccgtgcg ccctgggcgc ggcgctgagt gcgcgcggac cggtctacac 300 cgagcagccc ggagcgcccg cgcctgatct cccactgccc gacggcctct tgcaggtgcc 360 cttccgggac gcctggcctg gcaccttctc tttcatcatc gaaacctgga gagaggagtt 420 aggagaccag attggagggc ccgcctggag cctgctggcg cgcgtggctg gcaggcggcg 480 cttggcagcc ggaggcccgt gggcccggga cattcagcgc gcaggcgcct gggagctgcg 540 cttctcgtac cgcgcgcgct gcgagccgcc tgccgtcggg accgcgtgca cgcgcctctg 600 ccgtccgcgc agcgccccct cgcggtgcgg tccgggactg cgcccctgcg caccgctcga 660 ggacgaatgt gaggcgccgc tggtgtgccg agcaggctgc agccctgagc atggcttctg 720 tgaacagccc ggtgaatgcc gatgcctaga gggctggact ggacccctct gcacggtccc 780 tgtctccacc agcagctgcc tcagccccag gggcccgtcc tctgctacca ccggatgcct 840 tgtccctggg cctgggccct gtgacgggaa cccgtgtgcc aatggaggca gctgtagtga 900 gacacccagg tcctttgaat gcacctgccc gcgtgggttc tacgggctgc ggtgtgaggt 960 gagcggggtg acatgtgcag atggaccctg cttcaacggc ggcttgtgtg tcgggggtgc 1020 agaccctgac tctgcctaca tctgccactg cccacccggt ttccaaggct ccaactgtga 1080 gaagagggtg gaccggtgca gcctgcagcc atgccgcaat ggcggactct gcctggacct 1140 gggccacgcc ctgcgctgcc gctgccgcgc cggcttcgcg ggtcctcgct gcgagcacga 1200 cctggacgac tgcgcgggcc gcgcctgcgc taacggcggc acgtgtgtgg agggcggcgg 1260 cgcgcaccgc tgctcctgcg cgctgggctt cggcggccgc gactgccgcg agcgcgcgga 1320 cccgtgcgcc gcgcgcccct gtgctcacgg cggccgctgc tacgcccact tctccggcct 1380 cgtctgcgct tgcgctcccg gctacatggg agcgcggtgt gagttcccag tgcaccccga 1440 cggcgcaagc gccttgcccg cggccccgcc gggcctcagg cccggggacc ctcagcgcta 1500 ccttttgcct ccggctctgg gactgctcgt ggccgcgggc gtggccggcg ctgcgctctt 1560 gctggtccac gtgcgccgcc gtggccactc ccaggatgct gggtctcgct tgctggctgg 1620 gaccccggag ccgtcagtcc acgcactccc ggatgcactc aacaacctaa ggacgcagga 1680 gggttccggg gatggtccga gctcgtccgt agattggaat cgccctgaag atgtagaccc 1740 tcaagggatt tatgtcatat ctgctccttc catctacgct cgggaggtag cgacgcccct 1800 tttccccccg ctacacactg ggcgcgctgg gcagaggcag cacctgcttt ttccctaccc 1860 ttcctcgatt ctgtccgtga aatgaattgg gtagagtctc tggaaggttt taagcccatt 1920 ttcagttcta acttactttc atcctatttt gcatccctct tatcgttttg agctacctgc 1980 catcttctct ttgaaaaacc tatgggcttg aggaggtcac gatgccgact ccgccagagc 2040 ttttccactg attgtactca gcggggaggc aggggaggca gaggggcagc ctctctaatg 2100 cttcctactc attttgtttc taggcctgac gcgtctcctc catccgcacc tggagtcaga 2160 gcgtggattt ttgtatttgc tcggtggtgc ccagtctctg ccccagaggc tttggagttc 2220 aatcttgaag gggtgtctgg gggaacttta ctgttgcaag ttgtaaataa tggttattta 2280 tatcctattt tttctcaccc catctctcta gaaacaccta taaaggctat tattgtgatc 2340 a 2341 <210> 56 <211> 2004 <212> ADN <213> Homo sapiens <400> 56 actcccgaga cccccccacc agaaggccat ggtctcccca cggatgtccg ggctcctctc 60 ccagactgtg atcctagcgc tcattttcct cccccagaca cggcccgctg gcgtcttcga 120 gctgcagatc cactctttcg ggccgggtcc aggccctggg gccccgcggt ccccctgcag 180 cgcccggctc ccctgccgcc tcttcttcag agtctgcctg aagcctgggc tctcagagga 240 ggccgccgag tccccgtgcg ccctgggcgc ggcgctgagt gcgcgcggac cggtctacac 300 cgagcagccc ggagcgcccg cgcctgatct cccactgccc gacggcctct tgcaggtgcc 360 cttccgggac gcctggcctg gcaccttctc tttcatcatc gaaacctgga gagaggagtt 420 aggagaccag attggagggc ccgcctggag cctgctggcg cgcgtggctg gcaggcggcg 480 cttggcagcc ggaggcccgt gggcccggga cattcagcgc gcaggcgcct gggagctgcg 540 cttctcgtac cgcgcgcgct gcgagccgcc tgccgtcggg accgcgtgca cgcgcctctg 600 ccgtccgcgc agcgccccct cgcggtgcgg tccgggactg cgcccctgcg caccgctcga 660 ggacgaatgt gaggcgccgc tggtgtgccg agcaggctgc agccctgagc atggcttctg 720 tgaacagccc ggtgaatgcc gatgcctaga gggctggact ggacccctct gcacggtccc 780 tgtctccacc agcagctgcc tcagccccag gggcccgtcc tctgctacca ccggatgcct 840 tgtccctggg cctgggccct gtgacgggaa cccgtgtgcc aatggaggca gctgtagtga 900 gacacccagg tcctttgaat gcacctgccc gcgtgggttc tacgggctgc ggtgtgaggt 960 gagcggggtg acatgtgcag atggaccctg cttcaacggc ggcttgtgtg tcgggggtgc 1020 agaccctgac tctgcctaca tctgccactg cccacccggt ttccaaggct ccaactgtga 1080 gaagagggtg gaccggtgca gcctgcagcc atgccgcaat ggcggactct gcctggacct 1140 gggccacgcc ctgcgctgcc gctgccgcgc cggcttcgcg ggtcctcgct gcgagcacga 1200 cctggacgac tgcgcgggcc gcgcctgcgc taacggcggc acgtgtgtgg agggcggcgg 1260 cgcgcaccgc tgctcctgcg cgctgggctt cggcggccgc gactgccgcg agcgcgcgga 1320 cccgtgcgcc gcgcgcccct gtgctcacgg cggccgctgc tacgcccact tctccggcct 1380 cgtctgcgct tgcgctcccg gctacatggg agcgcggtgt gagttcccag tgcaccccga 1440 cggcgcaagc gccttgcccg cggccccgcc gggcctcagg cccggggacc ctcagcgcta 1500 ccttttgcct ccggctctgg gactgctcgt ggccgcgggc gtggccggcg ctgcgctctt 1560 gctggtccac gtgcgccgcc gtggccactc ccaggatgct gggtctcgct tgctggctgg 1620 gaccccggag ccgtcagtcc acgcactccc ggatgcactc aacaacctaa ggacgcagga 1680 gggttccggg gatggtccga gctcgtccgt agattggaat cgccctgaag atgtagaccc 1740 tcaagggatt tatgtcatat ctgctccttc catctacgct cgggaggcct gacgcgtctc 1800 ctccatccgc acctggagtc agagcgtgga tttttgtatt tgctcggtgg tgcccagtct 1860 ctgccccaga ggctttggag ttcaatcttg aaggggtgtc tgggggaact ttactgttgc 1920 aagttgtaaa taatggttat ttatatccta ttttttctca ccccatctct ctagaaacac 1980 ctataaaggc tattattgtg atca 2004 <210> 57 <211> 5 <212> PRT <213> Secuencia artificial <220> <223> Descripción de la secuencia artificial: Péptido sintético <400> 57 Gly Gly Gly Gly Ser 1 5 <210> 58 <211> 75 <212> PRT <213> Secuencia artificial <220> <223> Descripción de la secuencia artificial: Polipéptido sintético <220> <221> MISC_FEATURE <222> (1)..(75) <223> Esta secuencia puede abarcar unidades de repetición 1-15 "Gly Gly Gly Gly Ser" <220> <223> Véase la memoria descriptiva según se presentó para descripción detallada de sustituciones y realizaciones preferidas <400> 58 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 1 5 10 15 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 20 25 30 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 35 40 45 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 50 55 60 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 65 70 75 <210> 59 <211> 6 <212> PRT <213> Secuencia artificial <220> <223> Descripción de la secuencia artificial: Marcador 6xHis sintético <400> 59 His His His His His His 1 5