LISTADO DE SECUENCIAS <110> NOVARTIS AG <120> PROTEÍNAS DE FUSIÓN TERAPÉUTICAS <130> PAT058332 <140> <141> <150> EP 19196045.9 <151> 2019-09-06 <160> 148 <170> PatentIn versión 3.5 <210> 1 <211> 387 <212> PRT <213> Homo sapiens <400> 1 Met Pro Arg Pro Arg Leu Leu Ala Ala Leu Cys Gly Ala Leu Leu Cys 1 5 10 15 Ala Pro Ser Leu Leu Val Ala Leu Asp Ile Cys Ser Lys Asn Pro Cys 20 25 30 His Asn Gly Gly Leu Cys Glu Glu Ile Ser Gln Glu Val Arg Gly Asp 35 40 45 Val Phe Pro Ser Tyr Thr Cys Thr Cys Leu Lys Gly Tyr Ala Gly Asn 50 55 60 His Cys Glu Thr Lys Cys Val Glu Pro Leu Gly Leu Glu Asn Gly Asn 65 70 75 80 Ile Ala Asn Ser Gln Ile Ala Ala Ser Ser Val Arg Val Thr Phe Leu 85 90 95 Gly Leu Gln His Trp Val Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly 100 105 110 Met Val Asn Ala Trp Thr Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile 115 120 125 Gln Val Asn Leu Leu Arg Arg Met Trp Val Thr Gly Val Val Thr Gln 130 135 140 Gly Ala Ser Arg Leu Ala Ser His Glu Tyr Leu Lys Ala Phe Lys Val 145 150 155 160 Ala Tyr Ser Leu Asn Gly His Glu Phe Asp Phe Ile His Asp Val Asn 165 170 175 Lys Lys His Lys Glu Phe Val Gly Asn Trp Asn Lys Asn Ala Val His 180 185 190 Val Asn Leu Phe Glu Thr Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr 195 200 205 Pro Thr Ser Cys His Thr Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly 210 215 220 Cys Glu Leu Asn Gly Cys Ala Asn Pro Leu Gly Leu Lys Asn Asn Ser 225 230 235 240 Ile Pro Asp Lys Gln Ile Thr Ala Ser Ser Ser Tyr Lys Thr Trp Gly 245 250 255 Leu His Leu Phe Ser Trp Asn Pro Ser Tyr Ala Arg Leu Asp Lys Gln 260 265 270 Gly Asn Phe Asn Ala Trp Val Ala Gly Ser Tyr Gly Asn Asp Gln Trp 275 280 285 Leu Gln Val Asp Leu Gly Ser Ser Lys Glu Val Thr Gly Ile Ile Thr 290 295 300 Gln Gly Ala Arg Asn Phe Gly Ser Val Gln Phe Val Ala Ser Tyr Lys 305 310 315 320 Val Ala Tyr Ser Asn Asp Ser Ala Asn Trp Thr Glu Tyr Gln Asp Pro 325 330 335 Arg Thr Gly Ser Ser Lys Ile Phe Pro Gly Asn Trp Asp Asn His Ser 340 345 350 His Lys Lys Asn Leu Phe Glu Thr Pro Ile Leu Ala Arg Tyr Val Arg 355 360 365 Ile Leu Pro Val Ala Trp His Asn Arg Ile Ala Leu Arg Leu Glu Leu 370 375 380 Leu Gly Cys 385 <210> 2 <211> 46 <212> PRT <213> Homo sapiens <400> 2 Leu Asp Ile Cys Ser Lys Asn Pro Cys His Asn Gly Gly Leu Cys Glu 1 5 10 15 Glu Ile Ser Gln Glu Val Arg Gly Asp Val Phe Pro Ser Tyr Thr Cys 20 25 30 Thr Cys Leu Lys Gly Tyr Ala Gly Asn His Cys Glu Thr Lys 35 40 45 <210> 3 <211> 318 <212> PRT <213> Homo sapiens <400> 3 Cys Val Glu Pro Leu Gly Leu Glu Asn Gly Asn Ile Ala Asn Ser Gln 1 5 10 15 Ile Ala Ala Ser Ser Val Arg Val Thr Phe Leu Gly Leu Gln His Trp 20 25 30 Val Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly Met Val Asn Ala Trp 35 40 45 Thr Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile Gln Val Asn Leu Leu 50 55 60 Arg Arg Met Trp Val Thr Gly Val Val Thr Gln Gly Ala Ser Arg Leu 65 70 75 80 Ala Ser His Glu Tyr Leu Lys Ala Phe Lys Val Ala Tyr Ser Leu Asn 85 90 95 Gly His Glu Phe Asp Phe Ile His Asp Val Asn Lys Lys His Lys Glu 100 105 110 Phe Val Gly Asn Trp Asn Lys Asn Ala Val His Val Asn Leu Phe Glu 115 120 125 Thr Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr Pro Thr Ser Cys His 130 135 140 Thr Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly Cys Glu Leu Asn Gly 145 150 155 160 Cys Ala Asn Pro Leu Gly Leu Lys Asn Asn Ser Ile Pro Asp Lys Gln 165 170 175 Ile Thr Ala Ser Ser Ser Tyr Lys Thr Trp Gly Leu His Leu Phe Ser 180 185 190 Trp Asn Pro Ser Tyr Ala Arg Leu Asp Lys Gln Gly Asn Phe Asn Ala 195 200 205 Trp Val Ala Gly Ser Tyr Gly Asn Asp Gln Trp Leu Gln Val Asp Leu 210 215 220 Gly Ser Ser Lys Glu Val Thr Gly Ile Ile Thr Gln Gly Ala Arg Asn 225 230 235 240 Phe Gly Ser Val Gln Phe Val Ala Ser Tyr Lys Val Ala Tyr Ser Asn 245 250 255 Asp Ser Ala Asn Trp Thr Glu Tyr Gln Asp Pro Arg Thr Gly Ser Ser 260 265 270 Lys Ile Phe Pro Gly Asn Trp Asp Asn His Ser His Lys Lys Asn Leu 275 280 285 Phe Glu Thr Pro Ile Leu Ala Arg Tyr Val Arg Ile Leu Pro Val Ala 290 295 300 Trp His Asn Arg Ile Ala Leu Arg Leu Glu Leu Leu Gly Cys 305 310 315 <210> 4 <211> 583 <212> PRT <213> Homo sapiens <400> 4 Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 1 5 10 15 Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 20 25 30 Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 35 40 45 Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 50 55 60 Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 65 70 75 80 Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 85 90 95 Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 100 105 110 Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 115 120 125 Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 130 135 140 Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 145 150 155 160 Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 165 170 175 Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 180 185 190 Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 195 200 205 Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 210 215 220 Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 225 230 235 240 Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 245 250 255 Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 260 265 270 Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 275 280 285 Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 290 295 300 Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 305 310 315 320 Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 325 330 335 Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 340 345 350 Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 355 360 365 Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 370 375 380 Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 385 390 395 400 Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 405 410 415 Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 420 425 430 Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 435 440 445 Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 450 455 460 Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 465 470 475 480 Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 485 490 495 Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 500 505 510 Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 515 520 525 Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 530 535 540 Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 545 550 555 560 Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 565 570 575 Ala Ala Ser Gln Ala Ala Leu 580 <210> 5 <211> 583 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 5 Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 1 5 10 15 Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 20 25 30 Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 35 40 45 Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 50 55 60 Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 65 70 75 80 Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 85 90 95 Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 100 105 110 Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 115 120 125 Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 130 135 140 Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 145 150 155 160 Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 165 170 175 Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 180 185 190 Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 195 200 205 Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 210 215 220 Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 225 230 235 240 Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 245 250 255 Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 260 265 270 Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 275 280 285 Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 290 295 300 Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 305 310 315 320 Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 325 330 335 Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 340 345 350 Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 355 360 365 Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 370 375 380 Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 385 390 395 400 Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 405 410 415 Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 420 425 430 Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 435 440 445 Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 450 455 460 Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 465 470 475 480 Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 485 490 495 Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 500 505 510 Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 515 520 525 Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 530 535 540 Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 545 550 555 560 Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 565 570 575 Ala Ala Ser Gln Ala Ala Leu 580 <210> 6 <211> 206 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 6 Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe 1 5 10 15 Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr 20 25 30 Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser 35 40 45 Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala 50 55 60 Lys Arg Met Pro Cys Ala Glu Asp Cys Leu Ser Val Phe Leu Asn Gln 65 70 75 80 Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys 85 90 95 Cys Cys Thr Glu Ser Leu Val Asn Gly Arg Pro Cys Phe Ser Ala Leu 100 105 110 Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe 115 120 125 Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile 130 135 140 Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala 145 150 155 160 Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val 165 170 175 Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu 180 185 190 Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu 195 200 205 <210> 7 <211> 217 <212> PRT <213> Homo sapiens <400> 7 Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 1 5 10 15 Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 20 25 30 Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 35 40 45 Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 50 55 60 Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 65 70 75 80 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 85 90 95 Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 100 105 110 Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 115 120 125 Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 130 135 140 Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 145 150 155 160 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 165 170 175 Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 180 185 190 Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 195 200 205 Lys Ser Leu Ser Leu Ser Pro Gly Lys 210 215 <210> 8 <211> 217 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 8 Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 1 5 10 15 Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 20 25 30 Val Val Ala Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 35 40 45 Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 50 55 60 Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 65 70 75 80 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 85 90 95 Ala Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 100 105 110 Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 115 120 125 Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 130 135 140 Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 145 150 155 160 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 165 170 175 Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 180 185 190 Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 195 200 205 Lys Ser Leu Ser Leu Ser Pro Gly Lys 210 215 <210> 9 <211> 217 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 9 Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 1 5 10 15 Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 20 25 30 Val Val Ala Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 35 40 45 Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 50 55 60 Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 65 70 75 80 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 85 90 95 Ala Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 100 105 110 Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Glu Glu Met 115 120 125 Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro 130 135 140 Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 145 150 155 160 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 165 170 175 Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 180 185 190 Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 195 200 205 Lys Ser Leu Ser Leu Ser Pro Gly Lys 210 215 <210> 10 <211> 217 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 10 Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 1 5 10 15 Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 20 25 30 Val Val Ala Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 35 40 45 Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 50 55 60 Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 65 70 75 80 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 85 90 95 Ala Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 100 105 110 Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Glu Glu Met 115 120 125 Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro 130 135 140 Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 145 150 155 160 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 165 170 175 Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 180 185 190 Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 195 200 205 Lys Ser Leu Ser Leu Ser Pro Gly Lys 210 215 <210> 11 <211> 457 <212> PRT <213> Homo sapiens <400> 11 Asp Ile Cys Asp Pro Asn Pro Cys Glu Asn Gly Gly Ile Cys Leu Pro 1 5 10 15 Gly Leu Ala Asp Gly Ser Phe Ser Cys Glu Cys Pro Asp Gly Phe Thr 20 25 30 Asp Pro Asn Cys Ser Ser Val Val Glu Val Ala Ser Asp Glu Glu Glu 35 40 45 Pro Thr Ser Ala Gly Pro Cys Thr Pro Asn Pro Cys His Asn Gly Gly 50 55 60 Thr Cys Glu Ile Ser Glu Ala Tyr Arg Gly Asp Thr Phe Ile Gly Tyr 65 70 75 80 Val Cys Lys Cys Pro Arg Gly Phe Asn Gly Ile His Cys Gln His Asn 85 90 95 Ile Asn Glu Cys Glu Val Glu Pro Cys Lys Asn Gly Gly Ile Cys Thr 100 105 110 Asp Leu Val Ala Asn Tyr Ser Cys Glu Cys Pro Gly Glu Phe Met Gly 115 120 125 Arg Asn Cys Gln Tyr Lys Cys Ser Gly Pro Leu Gly Ile Glu Gly Gly 130 135 140 Ile Ile Ser Asn Gln Gln Ile Thr Ala Ser Ser Thr His Arg Ala Leu 145 150 155 160 Phe Gly Leu Gln Lys Trp Tyr Pro Tyr Tyr Ala Arg Leu Asn Lys Lys 165 170 175 Gly Leu Ile Asn Ala Trp Thr Ala Ala Glu Asn Asp Arg Trp Pro Trp 180 185 190 Ile Gln Ile Asn Leu Gln Arg Lys Met Arg Val Thr Gly Val Ile Thr 195 200 205 Gln Gly Ala Lys Arg Ile Gly Ser Pro Glu Tyr Ile Lys Ser Tyr Lys 210 215 220 Ile Ala Tyr Ser Asn Asp Gly Lys Thr Trp Ala Met Tyr Lys Val Lys 225 230 235 240 Gly Thr Asn Glu Asp Met Val Phe Arg Gly Asn Ile Asp Asn Asn Thr 245 250 255 Pro Tyr Ala Asn Ser Phe Thr Pro Pro Ile Lys Ala Gln Tyr Val Arg 260 265 270 Leu Tyr Pro Gln Val Cys Arg Arg His Cys Thr Leu Arg Met Glu Leu 275 280 285 Leu Gly Cys Glu Leu Ser Gly Cys Ser Glu Pro Leu Gly Met Lys Ser 290 295 300 Gly His Ile Gln Asp Tyr Gln Ile Thr Ala Ser Ser Ile Phe Arg Thr 305 310 315 320 Leu Asn Met Asp Met Phe Thr Trp Glu Pro Arg Lys Ala Arg Leu Asp 325 330 335 Lys Gln Gly Lys Val Asn Ala Trp Thr Ser Gly His Asn Asp Gln Ser 340 345 350 Gln Trp Leu Gln Val Asp Leu Leu Val Pro Thr Lys Val Thr Gly Ile 355 360 365 Ile Thr Gln Gly Ala Lys Asp Phe Gly His Val Gln Phe Val Gly Ser 370 375 380 Tyr Lys Leu Ala Tyr Ser Asn Asp Gly Glu His Trp Thr Val Tyr Gln 385 390 395 400 Asp Glu Lys Gln Arg Lys Asp Lys Val Phe Gln Gly Asn Phe Asp Asn 405 410 415 Asp Thr His Arg Lys Asn Val Ile Asp Pro Pro Ile Tyr Ala Arg His 420 425 430 Ile Arg Ile Leu Pro Trp Ser Trp Tyr Gly Arg Ile Thr Leu Arg Ser 435 440 445 Glu Leu Leu Gly Cys Thr Glu Glu Glu 450 455 <210> 12 <211> 1052 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 12 Asp Ile Cys Asp Pro Asn Pro Cys Glu Asn Gly Gly Ile Cys Leu Pro 1 5 10 15 Gly Leu Ala Asp Gly Ser Phe Ser Cys Glu Cys Pro Asp Gly Phe Thr 20 25 30 Asp Pro Asn Cys Ser Ser Val Val Glu Val Ala Ser Asp Glu Glu Glu 35 40 45 Pro Thr Ser Ala Gly Pro Cys Thr Pro Asn Pro Cys His Asn Gly Gly 50 55 60 Thr Cys Glu Ile Ser Glu Ala Tyr Arg Gly Asp Thr Phe Ile Gly Tyr 65 70 75 80 Val Cys Lys Cys Pro Arg Gly Phe Asn Gly Ile His Cys Gln His Asn 85 90 95 Ile Asn Glu Cys Glu Val Glu Pro Cys Lys Asn Gly Gly Ile Cys Thr 100 105 110 Asp Leu Val Ala Asn Tyr Ser Cys Glu Cys Pro Gly Glu Phe Met Gly 115 120 125 Arg Asn Cys Gln Tyr Lys Gly Ser Asp Ala His Lys Ser Glu Val Ala 130 135 140 His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 145 150 155 160 Ile Ala Phe Ala Gln Tyr Leu Gln Gln Ser Pro Phe Glu Asp His Val 165 170 175 Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 180 185 190 Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 195 200 205 Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 210 215 220 Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 225 230 235 240 His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 245 250 255 Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 260 265 270 Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 275 280 285 Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys 290 295 300 Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu 305 310 315 320 Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys 325 330 335 Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 340 345 350 Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser 355 360 365 Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly 370 375 380 Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 385 390 395 400 Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 405 410 415 Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp 420 425 430 Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser 435 440 445 Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 450 455 460 Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val 465 470 475 480 Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys 485 490 495 Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu 500 505 510 Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys 515 520 525 Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu 530 535 540 Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val 545 550 555 560 Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His 565 570 575 Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val 580 585 590 Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg 595 600 605 Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe 610 615 620 Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala 625 630 635 640 Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu 645 650 655 Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys 660 665 670 Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala 675 680 685 Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe 690 695 700 Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly 705 710 715 720 Leu Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Cys Ser Gly 725 730 735 Pro Leu Gly Ile Glu Gly Gly Ile Ile Ser Asn Gln Gln Ile Thr Ala 740 745 750 Ser Ser Thr His Arg Ala Leu Phe Gly Leu Gln Lys Trp Tyr Pro Tyr 755 760 765 Tyr Ala Arg Leu Asn Lys Lys Gly Leu Ile Asn Ala Trp Thr Ala Ala 770 775 780 Glu Asn Asp Arg Trp Pro Trp Ile Gln Ile Asn Leu Gln Arg Lys Met 785 790 795 800 Arg Val Thr Gly Val Ile Thr Gln Gly Ala Lys Arg Ile Gly Ser Pro 805 810 815 Glu Tyr Ile Lys Ser Tyr Lys Ile Ala Tyr Ser Asn Asp Gly Lys Thr 820 825 830 Trp Ala Met Tyr Lys Val Lys Gly Thr Asn Glu Asp Met Val Phe Arg 835 840 845 Gly Asn Ile Asp Asn Asn Thr Pro Tyr Ala Asn Ser Phe Thr Pro Pro 850 855 860 Ile Lys Ala Gln Tyr Val Arg Leu Tyr Pro Gln Val Cys Arg Arg His 865 870 875 880 Cys Thr Leu Arg Met Glu Leu Leu Gly Cys Glu Leu Ser Gly Cys Ser 885 890 895 Glu Pro Leu Gly Met Lys Ser Gly His Ile Gln Asp Tyr Gln Ile Thr 900 905 910 Ala Ser Ser Ile Phe Arg Thr Leu Asn Met Asp Met Phe Thr Trp Glu 915 920 925 Pro Arg Lys Ala Arg Leu Asp Lys Gln Gly Lys Val Asn Ala Trp Thr 930 935 940 Ser Gly His Asn Asp Gln Ser Gln Trp Leu Gln Val Asp Leu Leu Val 945 950 955 960 Pro Thr Lys Val Thr Gly Ile Ile Thr Gln Gly Ala Lys Asp Phe Gly 965 970 975 His Val Gln Phe Val Gly Ser Tyr Lys Leu Ala Tyr Ser Asn Asp Gly 980 985 990 Glu His Trp Thr Val Tyr Gln Asp Glu Lys Gln Arg Lys Asp Lys Val 995 1000 1005 Phe Gln Gly Asn Phe Asp Asn Asp Thr His Arg Lys Asn Val Ile 1010 1015 1020 Asp Pro Pro Ile Tyr Ala Arg His Ile Arg Ile Leu Pro Trp Ser 1025 1030 1035 Trp Tyr Gly Arg Ile Thr Leu Arg Ser Glu Leu Leu Gly Cys 1040 1045 1050 <210> 13 <211> 3156 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 13 gacatctgcg accccaatcc ttgcgagaat ggcggcattt gtctgcctgg actggccgat 60 ggcagcttct cttgtgaatg ccccgatggc ttcacagacc ccaattgcag ctctgtggtg 120 gaagtggcca gcgacgagga agaacctaca agcgctggcc cctgcacacc caatccatgt 180 cataatggcg gaacctgcga gatcagcgag gcctacagag gcgatacctt catcggctac 240 gtgtgcaagt gccccagagg cttcaatggc atccactgcc agcacaacat caacgagtgc 300 gaggtggaac catgcaagaa cggcggcatc tgtaccgacc tggtggccaa ttactcttgc 360 gagtgccctg gcgagttcat gggcagaaac tgccagtaca agggatccga cgctcacaag 420 tctgaggtgg cccacagatt caaggacctg ggcgaagaga acttcaaggc cctggtgctg 480 atcgccttcg ctcagtatct gcagcagagc cctttcgagg accacgtgaa gctggtcaac 540 gaagtgaccg agttcgccaa gacctgtgtg gccgatgaga gcgccgagaa ctgtgacaag 600 agcctgcaca cactgttcgg cgacaagctg tgtaccgtgg ccacactgag agaaacctac 660 ggcgagatgg ccgactgctg tgccaagcaa gagcccgaga gaaacgagtg cttcctgcag 720 cacaaggacg acaaccccaa cctgcctaga ctcgtgcgac ccgaagtgga tgtgatgtgc 780 accgcctttc acgacaacga ggaaaccttc ctgaagaagt acctgtacga gatcgccaga 840 cggcacccct acttttatgc ccctgagctg ctgttcttcg ccaagcggta taaggccgcc 900 ttcaccgaat gttgccaggc cgctgataag gctgcctgtc tgctgcctaa gctggacgag 960 ctgagagatg agggcaaagc cagctctgcc aagcagagac tgaagtgcgc cagcctgcag 1020 aagttcggcg agagagcttt taaggcctgg gccgttgcca gactgagcca gagatttcct 1080 aaggccgagt ttgccgaggt gtccaagctc gtgaccgatc tgacaaaggt gcacaccgag 1140 tgctgtcacg gcgatctgct ggaatgtgcc gacgatagag ccgacctggc caagtatatc 1200 tgcgagaacc aggacagcat cagcagcaag ctgaaagagt gctgcgagaa gcccctgctg 1260 gaaaagtctc actgtatcgc cgaggtcgag aacgacgaga tgcctgctga tctgcctagc 1320 ctggccgccg atttcgtgga aagcaaggat gtgtgcaaga actacgccga ggccaaagat 1380 gtgtttctgg gcatgtttct gtatgagtac gcccgcagac accccgacta ttctgtggtt 1440 ctgctgctgc ggctggccaa gacatacgag acaaccctgg aaaaatgctg cgccgctgcc 1500 gatcctcacg agtgttatgc caaggtgttc gacgagttca agccactggt ggaagaaccc 1560 cagaacctga tcaagcagaa ctgcgagctg ttcgagcagc tgggcgagta caagttccag 1620 aatgccctgc tcgtgcggta caccaagaaa gtgcctcagg tgtccacacc tacactggtt 1680 gaggtgtccc ggaatctggg caaagtgggc agcaagtgtt gcaagcaccc tgaggccaag 1740 agaatgcctt gcgccgagga ttacctgagc gtggtgctga atcagctgtg cgtgctgcac 1800 gagaaaaccc ctgtgtccga cagagtgacc aagtgctgta ccgagagcct cgtgaacaga 1860 aggccttgct ttagcgccct ggaagtggac gagacatacg tgcccaaaga gttcaacgcc 1920 gagacattca ccttccacgc cgatatctgc accctgtccg agaaagagcg gcagatcaag 1980 aagcagacag ccctggtcga gctggttaag cacaagccca aggccaccaa agaacagctg 2040 aaggccgtga tggacgactt cgccgccttt gtcgagaagt gctgcaaggc cgacgacaaa 2100 gagacatgct tcgccgaaga gggcaagaaa ctggtggctg cctctcaggc tgctctcgga 2160 cttggaggaa gcggaggatc tggcggttcc ggaggaagtt gttctggccc tcttggcatc 2220 gaaggcggca tcatcagcaa tcagcagatc accgccagca gcacccacag agcactgttt 2280 ggactgcaga aatggtatcc ctactacgcc cggctgaaca agaagggcct gattaacgcc 2340 tggacagccg ccgagaatga cagatggccc tggattcaga tcaacctgca gcggaagatg 2400 agagtgaccg gcgttatcac acagggcgcc aaaagaatcg gcagccccga gtacatcaag 2460 agctacaaga tcgcctacag caacgacggc aagacctggg ccatgtacaa agtgaagggc 2520 accaacgagg acatggtgtt ccggggcaac atcgacaaca acacccctta cgccaacagc 2580 ttcacccctc ctatcaaggc ccagtacgtg cggctgtacc ctcaagtgtg cagaaggcac 2640 tgtaccctga gaatggaact gctgggctgc gaactgtctg gctgttctga gccactgggc 2700 atgaagtccg gccacatcca ggattaccag atcacagcct ccagcatctt cagaaccctg 2760 aacatggata tgttcacctg ggagccccgg aaggccagac tggataagca gggaaaagtg 2820 aatgcctgga ccagcggcca caacgaccag tctcaatggc tgcaagtgga cctgctggtg 2880 cccaccaaag tgaccggaat cattactcag ggcgcaaagg acttcggcca cgtgcagttt 2940 gtgggctcct acaagctggc ctactccaac gatggcgagc actggacagt gtaccaggac 3000 gagaagcagc gcaaggataa ggtgttccag ggaaacttcg ataacgatac ccaccggaag 3060 aacgtgatcg accctccaat ctacgccaga cacatcagaa tcctgccttg gtcttggtac 3120 ggcagaatca ccctgagatc cgagctgctg ggatgc 3156 <210> 14 <211> 596 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 14 Leu Asp Ile Cys Ser Lys Asn Pro Cys His Asn Gly Gly Leu Cys Glu 1 5 10 15 Glu Ile Ser Gln Glu Val Arg Gly Asp Val Phe Pro Ser Tyr Thr Cys 20 25 30 Thr Cys Leu Lys Gly Tyr Ala Gly Asn His Cys Glu Thr Lys Cys Val 35 40 45 Glu Pro Leu Gly Met Glu Asn Gly Asn Ile Ala Asn Ser Gln Ile Ala 50 55 60 Ala Ser Ser Val Arg Val Thr Phe Leu Gly Leu Gln His Trp Val Pro 65 70 75 80 Glu Leu Ala Arg Leu Asn Arg Ala Gly Met Val Asn Ala Trp Thr Pro 85 90 95 Ser Ser Asn Asp Asp Asn Pro Trp Ile Gln Val Asn Leu Leu Arg Arg 100 105 110 Met Trp Val Thr Gly Val Val Thr Gln Gly Ala Ser Arg Leu Ala Ser 115 120 125 His Glu Tyr Leu Lys Ala Phe Lys Val Ala Tyr Ser Leu Asn Gly His 130 135 140 Glu Phe Asp Phe Ile His Asp Val Asn Lys Lys His Lys Glu Phe Val 145 150 155 160 Gly Asn Trp Asn Lys Asn Ala Val His Val Asn Leu Phe Glu Thr Pro 165 170 175 Val Glu Ala Gln Tyr Val Arg Leu Tyr Pro Thr Ser Cys His Thr Ala 180 185 190 Cys Thr Leu Arg Phe Glu Leu Leu Gly Cys Glu Leu Asn Gly Cys Ala 195 200 205 Asn Pro Leu Gly Leu Lys Asn Asn Ser Ile Pro Asp Lys Gln Ile Thr 210 215 220 Ala Ser Ser Ser Tyr Lys Thr Trp Gly Leu His Leu Phe Ser Trp Asn 225 230 235 240 Pro Ser Tyr Ala Arg Leu Asp Lys Gln Gly Asn Phe Asn Ala Trp Val 245 250 255 Ala Gly Ser Tyr Gly Asn Asp Gln Trp Leu Gln Val Asp Leu Gly Ser 260 265 270 Ser Lys Glu Val Thr Gly Ile Ile Thr Gln Gly Ala Arg Asn Phe Gly 275 280 285 Ser Val Gln Phe Val Ala Ser Tyr Lys Val Ala Tyr Ser Asn Asp Ser 290 295 300 Ala Asn Trp Thr Glu Tyr Gln Asp Pro Arg Thr Gly Ser Ser Lys Ile 305 310 315 320 Phe Pro Gly Asn Trp Asp Asn His Ser His Lys Lys Asn Leu Phe Glu 325 330 335 Thr Pro Ile Leu Ala Arg Tyr Val Arg Ile Leu Pro Val Ala Trp His 340 345 350 Asn Arg Ile Ala Leu Arg Leu Glu Leu Leu Gly Cys Gly Gly Gly Gly 355 360 365 Thr Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 370 375 380 Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 385 390 395 400 Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 405 410 415 His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 420 425 430 Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 435 440 445 Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 450 455 460 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 465 470 475 480 Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 485 490 495 Val Tyr Thr Leu Pro Pro Cys Arg Glu Glu Met Thr Lys Asn Gln Val 500 505 510 Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 515 520 525 Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 530 535 540 Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 545 550 555 560 Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 565 570 575 Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 580 585 590 Ser Pro Gly Lys 595 <210> 15 <211> 1788 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 15 ctggacatct gcagcaagaa cccctgccac aacggcggcc tgtgcgaaga gatcagccag 60 gaagtgcggg gcgacgtgtt ccccagctac acctgtacct gcctgaaggg ctacgccggc 120 aaccactgcg agactaagtg cgtggaaccc ctgggcatgg aaaacggcaa tattgccaac 180 agccagatcg ccgccagctc cgtgcgcgtg acctttctgg gactgcagca ctgggtgccc 240 gagctggcca gactgaacag agccggcatg gtgaacgcct ggacccccag cagcaacgac 300 gacaaccctt ggatccaggt gaacctgctg cggcggatgt gggtgacagg cgtggtgaca 360 cagggcgcca gcagactggc cagccacgag tacctgaagg cctttaaggt ggcctacagc 420 ctgaacggcc acgagttcga cttcatccac gacgtgaaca agaaacacaa agaatttgtg 480 ggcaactgga acaagaacgc cgtgcacgtg aacctgttcg agacacccgt ggaagcccag 540 tacgtgcggc tgtaccccac cagctgccac accgcctgca ccctgagatt cgagctgctg 600 ggctgcgagc tgaacggctg cgccaacccc ctgggcctga agaacaacag catccccgac 660 aagcagatca ccgcctccag cagctacaag acctggggcc tgcacctgtt cagctggaac 720 cccagctacg cccggctgga caagcagggc aacttcaacg cctgggtggc cggcagctac 780 ggcaacgacc agtggctgca ggtggacctg ggcagcagca aagaagtgac cggcatcatc 840 acccaggggg ccagaaactt cggcagcgtg cagttcgtgg ccagctacaa agtggcctac 900 tccaacgaca gcgccaactg gaccgagtac caggaccccc ggaccggcag ctccaagatc 960 ttccccggca actgggacaa ccacagccac aagaagaatc tgttcgaaac ccccatcctg 1020 gccagatacg tgcggatcct gcccgtggcc tggcacaacc ggatcgccct gagactggaa 1080 ctgctgggat gtgggggagg cggtaccgac aagacccaca cctgcccccc ctgcccagcc 1140 ccagagctgc tgggcggacc ctccgtgttc ctgttccccc ccaagcccaa ggacaccctg 1200 atgatcagca ggacccccga ggtgacctgc gtggtggtgg acgtgagcca cgaggaccca 1260 gaggtgaagt tcaactggta cgtggacggc gtggaggtgc acaacgccaa gaccaagccc 1320 agagaggagc agtacaacag cacctacagg gtggtgtccg tgctgaccgt gctgcaccag 1380 gactggctga acggcaagga atacaagtgc aaggtctcca acaaggccct gccagccccc 1440 atcgaaaaga ccatcagcaa ggccaagggc cagccacggg agccccaggt gtacaccctg 1500 cccccctgcc gggaggagat gaccaagaac caggtgtccc tgtggtgtct ggtgaagggc 1560 ttctacccca gcgacatcgc cgtggagtgg gagagcaacg gccagcccga gaacaactac 1620 aagaccaccc ccccagtgct ggacagcgac ggcagcttct tcctgtacag caagctgacc 1680 gtggacaagt ccaggtggca gcagggcaac gtgttcagct gcagcgtgat gcacgaggcc 1740 ctgcacaacc actacaccca gaagagcctg agcctgtccc ccggcaag 1788 <210> 16 <211> 613 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 16 Leu Asp Ile Cys Ser Lys Asn Pro Cys His Asn Gly Gly Leu Cys Glu 1 5 10 15 Glu Ile Ser Gln Glu Val Arg Gly Asp Val Phe Pro Ser Tyr Thr Cys 20 25 30 Thr Cys Leu Lys Gly Tyr Ala Gly Asn His Cys Glu Thr Lys Gly Ser 35 40 45 Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 50 55 60 Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 65 70 75 80 Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 85 90 95 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 100 105 110 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 115 120 125 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 130 135 140 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 145 150 155 160 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 165 170 175 Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 180 185 190 Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 195 200 205 Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 210 215 220 Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 225 230 235 240 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 245 250 255 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 260 265 270 Pro Gly Lys Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Cys 275 280 285 Val Glu Pro Leu Gly Met Glu Asn Gly Asn Ile Ala Asn Ser Gln Ile 290 295 300 Ala Ala Ser Ser Val Arg Val Thr Phe Leu Gly Leu Gln His Trp Val 305 310 315 320 Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly Met Val Asn Ala Trp Thr 325 330 335 Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile Gln Val Asn Leu Leu Arg 340 345 350 Arg Met Trp Val Thr Gly Val Val Thr Gln Gly Ala Ser Arg Leu Ala 355 360 365 Ser His Glu Tyr Leu Lys Ala Phe Lys Val Ala Tyr Ser Leu Asn Gly 370 375 380 His Glu Phe Asp Phe Ile His Asp Val Asn Lys Lys His Lys Glu Phe 385 390 395 400 Val Gly Asn Trp Asn Lys Asn Ala Val His Val Asn Leu Phe Glu Thr 405 410 415 Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr Pro Thr Ser Cys His Thr 420 425 430 Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly Cys Glu Leu Asn Gly Cys 435 440 445 Ala Asn Pro Leu Gly Leu Lys Asn Asn Ser Ile Pro Asp Lys Gln Ile 450 455 460 Thr Ala Ser Ser Ser Tyr Lys Thr Trp Gly Leu His Leu Phe Ser Trp 465 470 475 480 Asn Pro Ser Tyr Ala Arg Leu Asp Lys Gln Gly Asn Phe Asn Ala Trp 485 490 495 Val Ala Gly Ser Tyr Gly Asn Asp Gln Trp Leu Gln Val Asp Leu Gly 500 505 510 Ser Ser Lys Glu Val Thr Gly Ile Ile Thr Gln Gly Ala Arg Asn Phe 515 520 525 Gly Ser Val Gln Phe Val Ala Ser Tyr Lys Val Ala Tyr Ser Asn Asp 530 535 540 Ser Ala Asn Trp Thr Glu Tyr Gln Asp Pro Arg Thr Gly Ser Ser Lys 545 550 555 560 Ile Phe Pro Gly Asn Trp Asp Asn His Ser His Lys Lys Asn Leu Phe 565 570 575 Glu Thr Pro Ile Leu Ala Arg Tyr Val Arg Ile Leu Pro Val Ala Trp 580 585 590 His Asn Arg Ile Ala Leu Arg Leu Glu Leu Leu Gly Cys Gly Ser His 595 600 605 His His His His His 610 <210> 17 <211> 1839 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 17 ctggacatct gcagcaagaa tccttgccac aacggcggcc tgtgcgaaga gatttctcaa 60 gaagtgcggg gcgacgtttt ccccagctac acctgtacat gtctgaaggg ctacgccggc 120 aaccactgcg agacaaaagg atccgacaag acccacacct gccccccctg cccagcccca 180 gagctgctgg gcggaccctc cgtgttcctg ttccccccca agcccaagga caccctgatg 240 atcagcagga cccccgaggt gacctgcgtg gtggtggacg tgagccacga ggacccagag 300 gtgaagttca actggtacgt ggacggcgtg gaggtgcaca acgccaagac caagcccaga 360 gaggagcagt acaacagcac ctacagggtg gtgtccgtgc tgaccgtgct gcaccaggac 420 tggctgaacg gcaaggaata caagtgcaag gtctccaaca aggccctgcc agcccccatc 480 gaaaagacca tcagcaaggc caagggccag ccacgggagc cccaggtgta caccctgccc 540 ccctcccggg aggagatgac caagaaccag gtgtccctga cctgtctggt gaagggcttc 600 taccccagcg acatcgccgt ggagtgggag agcaacggcc agcccgagaa caactacaag 660 accacccccc cagtgctgga cagcgacggc agcttcttcc tgtacagcaa gctgaccgtg 720 gacaagtcca ggtggcagca gggcaacgtg ttcagctgca gcgtgatgca cgaggccctg 780 cacaaccact acacccagaa gagcctgagc ctgtcccccg gcaagggagg aagcggagga 840 tctggcggtt ccggaggctc ttgtgtggaa cccctcggca tggaaaacgg caatatcgcc 900 aatagccaga ttgccgccag cagcgtcaga gtgacatttc tgggactgca gcactgggtg 960 cccgagctgg ctagactgaa tagagccggc atggtcaacg cctggacacc cagcagcaac 1020 gacgataacc cttggattca agtgaacctg ctgcggcgta tgtgggtcac aggtgttgtt 1080 acacagggcg cctctagact ggccagccac gagtatctga aggcctttaa ggtggcctac 1140 agcctgaacg gccacgagtt cgacttcatc cacgacgtga acaagaagca caaagagttt 1200 gtcggcaact ggaacaagaa cgccgtgcac gtgaacctgt tcgagacacc tgtggaagcc 1260 cagtacgtgc ggctgtaccc tacaagctgt cacaccgcct gcactctgag attcgaactg 1320 ctgggatgcg agctgaacgg ctgtgctaat cctctgggcc tgaagaacaa cagcatcccc 1380 gataagcaga tcaccgccag ctccagctat aagacatggg gcctgcacct gttcagctgg 1440 aacccttctt acgccagact ggacaagcag ggcaacttca atgcttgggt ggccggcagc 1500 tacggcaatg atcagtggct gcaagtggac ctgggcagca gcaaagaagt gacaggcatc 1560 atcacccagg gcgccagaaa tttcggcagc gtgcagtttg tggccagcta caaagtggcc 1620 tactccaacg acagcgccaa ctggaccgag tatcaggacc ctagaaccgg cagctccaag 1680 atcttccccg gcaattggga caaccacagc cacaagaaga atctgttcga aacccctatc 1740 ctggccagat atgtgcgcat tctgcccgtg gcctggcaca acagaattgc cctgagactg 1800 gaactgctcg gctgtggctc tcaccaccac catcaccat 1839 <210> 18 <211> 613 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 18 Leu Asp Ile Cys Ser Lys Asn Pro Cys His Asn Gly Gly Leu Cys Glu 1 5 10 15 Glu Ile Ser Gln Glu Val Arg Gly Asp Val Phe Pro Ser Tyr Thr Cys 20 25 30 Thr Cys Leu Lys Gly Tyr Ala Gly Asn His Cys Glu Thr Lys Gly Ser 35 40 45 Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 50 55 60 Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 65 70 75 80 Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 85 90 95 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 100 105 110 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 115 120 125 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 130 135 140 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 145 150 155 160 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 165 170 175 Tyr Thr Leu Pro Pro Cys Arg Glu Glu Met Thr Lys Asn Gln Val Ser 180 185 190 Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 195 200 205 Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 210 215 220 Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 225 230 235 240 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 245 250 255 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 260 265 270 Pro Gly Lys Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Cys 275 280 285 Val Glu Pro Leu Gly Met Glu Asn Gly Asn Ile Ala Asn Ser Gln Ile 290 295 300 Ala Ala Ser Ser Val Arg Val Thr Phe Leu Gly Leu Gln His Trp Val 305 310 315 320 Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly Met Val Asn Ala Trp Thr 325 330 335 Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile Gln Val Asn Leu Leu Arg 340 345 350 Arg Met Trp Val Thr Gly Val Val Thr Gln Gly Ala Ser Arg Leu Ala 355 360 365 Ser His Glu Tyr Leu Lys Ala Phe Lys Val Ala Tyr Ser Leu Asn Gly 370 375 380 His Glu Phe Asp Phe Ile His Asp Val Asn Lys Lys His Lys Glu Phe 385 390 395 400 Val Gly Asn Trp Asn Lys Asn Ala Val His Val Asn Leu Phe Glu Thr 405 410 415 Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr Pro Thr Ser Cys His Thr 420 425 430 Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly Cys Glu Leu Asn Gly Cys 435 440 445 Ala Asn Pro Leu Gly Leu Lys Asn Asn Ser Ile Pro Asp Lys Gln Ile 450 455 460 Thr Ala Ser Ser Ser Tyr Lys Thr Trp Gly Leu His Leu Phe Ser Trp 465 470 475 480 Asn Pro Ser Tyr Ala Arg Leu Asp Lys Gln Gly Asn Phe Asn Ala Trp 485 490 495 Val Ala Gly Ser Tyr Gly Asn Asp Gln Trp Leu Gln Val Asp Leu Gly 500 505 510 Ser Ser Lys Glu Val Thr Gly Ile Ile Thr Gln Gly Ala Arg Asn Phe 515 520 525 Gly Ser Val Gln Phe Val Ala Ser Tyr Lys Val Ala Tyr Ser Asn Asp 530 535 540 Ser Ala Asn Trp Thr Glu Tyr Gln Asp Pro Arg Thr Gly Ser Ser Lys 545 550 555 560 Ile Phe Pro Gly Asn Trp Asp Asn His Ser His Lys Lys Asn Leu Phe 565 570 575 Glu Thr Pro Ile Leu Ala Arg Tyr Val Arg Ile Leu Pro Val Ala Trp 580 585 590 His Asn Arg Ile Ala Leu Arg Leu Glu Leu Leu Gly Cys Gly Ser His 595 600 605 His His His His His 610 <210> 19 <211> 1839 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 19 ctggacatct gcagcaagaa tccttgccac aacggcggcc tgtgcgaaga gatttctcaa 60 gaagtgcggg gcgacgtttt ccccagctac acctgtacat gtctgaaggg ctacgccggc 120 aaccactgcg agacaaaagg atccgacaag acccacacct gccccccctg cccagcccca 180 gagctgctgg gcggaccctc cgtgttcctg ttccccccca agcccaagga caccctgatg 240 atcagcagga cccccgaggt gacctgcgtg gtggtggacg tgagccacga ggacccagag 300 gtgaagttca actggtacgt ggacggcgtg gaggtgcaca acgccaagac caagcccaga 360 gaggagcagt acaacagcac ctacagggtg gtgtccgtgc tgaccgtgct gcaccaggac 420 tggctgaacg gcaaggaata caagtgcaag gtctccaaca aggccctgcc agcccccatc 480 gaaaagacca tcagcaaggc caagggccag ccacgggagc cccaggtgta caccctgccc 540 ccctgccggg aggagatgac caagaaccag gtgtccctgt ggtgtctggt gaagggcttc 600 taccccagcg acatcgccgt ggagtgggag agcaacggcc agcccgagaa caactacaag 660 accacccccc cagtgctgga cagcgacggc agcttcttcc tgtacagcaa gctgaccgtg 720 gacaagtcca ggtggcagca gggcaacgtg ttcagctgca gcgtgatgca cgaggccctg 780 cacaaccact acacccagaa gagcctgagc ctgtcccccg gcaagggagg aagcggagga 840 tctggcggtt ccggaggctc ttgtgtggaa cccctcggca tggaaaacgg caatatcgcc 900 aatagccaga ttgccgccag cagcgtcaga gtgacatttc tgggactgca gcactgggtg 960 cccgagctgg ctagactgaa tagagccggc atggtcaacg cctggacacc cagcagcaac 1020 gacgataacc cttggattca agtgaacctg ctgcggcgta tgtgggtcac aggtgttgtt 1080 acacagggcg cctctagact ggccagccac gagtatctga aggcctttaa ggtggcctac 1140 agcctgaacg gccacgagtt cgacttcatc cacgacgtga acaagaagca caaagagttt 1200 gtcggcaact ggaacaagaa cgccgtgcac gtgaacctgt tcgagacacc tgtggaagcc 1260 cagtacgtgc ggctgtaccc tacaagctgt cacaccgcct gcactctgag attcgaactg 1320 ctgggatgcg agctgaacgg ctgtgctaat cctctgggcc tgaagaacaa cagcatcccc 1380 gataagcaga tcaccgccag ctccagctat aagacatggg gcctgcacct gttcagctgg 1440 aacccttctt acgccagact ggacaagcag ggcaacttca atgcttgggt ggccggcagc 1500 tacggcaatg atcagtggct gcaagtggac ctgggcagca gcaaagaagt gacaggcatc 1560 atcacccagg gcgccagaaa tttcggcagc gtgcagtttg tggccagcta caaagtggcc 1620 tactccaacg acagcgccaa ctggaccgag tatcaggacc ctagaaccgg cagctccaag 1680 atcttccccg gcaattggga caaccacagc cacaagaaga atctgttcga aacccctatc 1740 ctggccagat atgtgcgcat tctgcccgtg gcctggcaca acagaattgc cctgagactg 1800 gaactgctcg gctgtggctc tcaccaccac catcaccat 1839 <210> 20 <211> 613 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 20 Leu Asp Ile Cys Ser Lys Asn Pro Cys His Asn Gly Gly Leu Cys Glu 1 5 10 15 Glu Ile Ser Gln Glu Val Arg Gly Asp Val Phe Pro Ser Tyr Thr Cys 20 25 30 Thr Cys Leu Lys Gly Tyr Ala Gly Asn His Cys Glu Thr Lys Gly Ser 35 40 45 Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 50 55 60 Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 65 70 75 80 Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 85 90 95 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 100 105 110 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 115 120 125 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 130 135 140 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 145 150 155 160 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 165 170 175 Cys Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 180 185 190 Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 195 200 205 Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 210 215 220 Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 225 230 235 240 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 245 250 255 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 260 265 270 Pro Gly Lys Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Cys 275 280 285 Val Glu Pro Leu Gly Met Glu Asn Gly Asn Ile Ala Asn Ser Gln Ile 290 295 300 Ala Ala Ser Ser Val Arg Val Thr Phe Leu Gly Leu Gln His Trp Val 305 310 315 320 Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly Met Val Asn Ala Trp Thr 325 330 335 Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile Gln Val Asn Leu Leu Arg 340 345 350 Arg Met Trp Val Thr Gly Val Val Thr Gln Gly Ala Ser Arg Leu Ala 355 360 365 Ser His Glu Tyr Leu Lys Ala Phe Lys Val Ala Tyr Ser Leu Asn Gly 370 375 380 His Glu Phe Asp Phe Ile His Asp Val Asn Lys Lys His Lys Glu Phe 385 390 395 400 Val Gly Asn Trp Asn Lys Asn Ala Val His Val Asn Leu Phe Glu Thr 405 410 415 Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr Pro Thr Ser Cys His Thr 420 425 430 Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly Cys Glu Leu Asn Gly Cys 435 440 445 Ala Asn Pro Leu Gly Leu Lys Asn Asn Ser Ile Pro Asp Lys Gln Ile 450 455 460 Thr Ala Ser Ser Ser Tyr Lys Thr Trp Gly Leu His Leu Phe Ser Trp 465 470 475 480 Asn Pro Ser Tyr Ala Arg Leu Asp Lys Gln Gly Asn Phe Asn Ala Trp 485 490 495 Val Ala Gly Ser Tyr Gly Asn Asp Gln Trp Leu Gln Val Asp Leu Gly 500 505 510 Ser Ser Lys Glu Val Thr Gly Ile Ile Thr Gln Gly Ala Arg Asn Phe 515 520 525 Gly Ser Val Gln Phe Val Ala Ser Tyr Lys Val Ala Tyr Ser Asn Asp 530 535 540 Ser Ala Asn Trp Thr Glu Tyr Gln Asp Pro Arg Thr Gly Ser Ser Lys 545 550 555 560 Ile Phe Pro Gly Asn Trp Asp Asn His Ser His Lys Lys Asn Leu Phe 565 570 575 Glu Thr Pro Ile Leu Ala Arg Tyr Val Arg Ile Leu Pro Val Ala Trp 580 585 590 His Asn Arg Ile Ala Leu Arg Leu Glu Leu Leu Gly Cys Gly Ser His 595 600 605 His His His His His 610 <210> 21 <211> 1839 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 21 ctggacatct gcagcaagaa tccttgccac aacggcggcc tgtgcgaaga gatttctcaa 60 gaagtgcggg gcgacgtttt ccccagctac acctgtacat gtctgaaggg ctacgccggc 120 aaccactgcg agacaaaagg atccgacaag acccacacct gccccccctg cccagcccca 180 gagctgctgg gcggaccctc cgtgttcctg ttccccccca agcccaagga caccctgatg 240 atcagcagga cccccgaggt gacctgcgtg gtggtggacg tgagccacga ggacccagag 300 gtgaagttca actggtacgt ggacggcgtg gaggtgcaca acgccaagac caagcccaga 360 gaggagcagt acaacagcac ctacagggtg gtgtccgtgc tgaccgtgct gcaccaggac 420 tggctgaacg gcaaggaata caagtgcaag gtctccaaca aggccctgcc agcccccatc 480 gaaaagacca tcagcaaggc caagggccag ccacgggagc cccaggtgtg caccctgccc 540 ccctcccggg aggagatgac caagaaccag gtgtccctgt cctgtgcggt gaagggcttc 600 taccccagcg acatcgccgt ggagtgggag agcaacggcc agcccgagaa caactacaag 660 accacccccc cagtgctgga cagcgacggc agcttcttcc tggtcagcaa gctgaccgtg 720 gacaagtcca ggtggcagca gggcaacgtg ttcagctgca gcgtgatgca cgaggccctg 780 cacaaccact acacccagaa gagcctgagc ctgtcccccg gcaagggagg aagcggagga 840 tctggcggtt ccggaggctc ttgtgtggaa cccctcggca tggaaaacgg caatatcgcc 900 aatagccaga ttgccgccag cagcgtcaga gtgacatttc tgggactgca gcactgggtg 960 cccgagctgg ctagactgaa tagagccggc atggtcaacg cctggacacc cagcagcaac 1020 gacgataacc cttggattca agtgaacctg ctgcggcgta tgtgggtcac aggtgttgtt 1080 acacagggcg cctctagact ggccagccac gagtatctga aggcctttaa ggtggcctac 1140 agcctgaacg gccacgagtt cgacttcatc cacgacgtga acaagaagca caaagagttt 1200 gtcggcaact ggaacaagaa cgccgtgcac gtgaacctgt tcgagacacc tgtggaagcc 1260 cagtacgtgc ggctgtaccc tacaagctgt cacaccgcct gcactctgag attcgaactg 1320 ctgggatgcg agctgaacgg ctgtgctaat cctctgggcc tgaagaacaa cagcatcccc 1380 gataagcaga tcaccgccag ctccagctat aagacatggg gcctgcacct gttcagctgg 1440 aacccttctt acgccagact ggacaagcag ggcaacttca atgcttgggt ggccggcagc 1500 tacggcaatg atcagtggct gcaagtggac ctgggcagca gcaaagaagt gacaggcatc 1560 atcacccagg gcgccagaaa tttcggcagc gtgcagtttg tggccagcta caaagtggcc 1620 tactccaacg acagcgccaa ctggaccgag tatcaggacc ctagaaccgg cagctccaag 1680 atcttccccg gcaattggga caaccacagc cacaagaaga atctgttcga aacccctatc 1740 ctggccagat atgtgcgcat tctgcccgtg gcctggcaca acagaattgc cctgagactg 1800 gaactgctcg gctgtggctc tcaccaccac catcaccat 1839 <210> 22 <211> 596 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 22 Leu Asp Ile Cys Ser Lys Asn Pro Cys His Asn Gly Gly Leu Cys Glu 1 5 10 15 Glu Ile Ser Gln Glu Val Arg Gly Asp Val Phe Pro Ser Tyr Thr Cys 20 25 30 Thr Cys Leu Lys Gly Tyr Ala Gly Asn His Cys Glu Thr Lys Cys Val 35 40 45 Glu Pro Leu Gly Met Glu Asn Gly Asn Ile Ala Asn Ser Gln Ile Ala 50 55 60 Ala Ser Ser Val Arg Val Thr Phe Leu Gly Leu Gln His Trp Val Pro 65 70 75 80 Glu Leu Ala Arg Leu Asn Arg Ala Gly Met Val Asn Ala Trp Thr Pro 85 90 95 Ser Ser Asn Asp Asp Asn Pro Trp Ile Gln Val Asn Leu Leu Arg Arg 100 105 110 Met Trp Val Thr Gly Val Val Thr Gln Gly Ala Ser Arg Leu Ala Ser 115 120 125 His Glu Tyr Leu Lys Ala Phe Lys Val Ala Tyr Ser Leu Asn Gly His 130 135 140 Glu Phe Asp Phe Ile His Asp Val Asn Lys Lys His Lys Glu Phe Val 145 150 155 160 Gly Asn Trp Asn Lys Asn Ala Val His Val Asn Leu Phe Glu Thr Pro 165 170 175 Val Glu Ala Gln Tyr Val Arg Leu Tyr Pro Thr Ser Cys His Thr Ala 180 185 190 Cys Thr Leu Arg Phe Glu Leu Leu Gly Cys Glu Leu Asn Gly Cys Ala 195 200 205 Asn Pro Leu Gly Leu Lys Asn Asn Ser Ile Pro Asp Lys Gln Ile Thr 210 215 220 Ala Ser Ser Ser Tyr Lys Thr Trp Gly Leu His Leu Phe Ser Trp Asn 225 230 235 240 Pro Ser Tyr Ala Arg Leu Asp Lys Gln Gly Asn Phe Asn Ala Trp Val 245 250 255 Ala Gly Ser Tyr Gly Asn Asp Gln Trp Leu Gln Val Asp Leu Gly Ser 260 265 270 Ser Lys Glu Val Thr Gly Ile Ile Thr Gln Gly Ala Arg Asn Phe Gly 275 280 285 Ser Val Gln Phe Val Ala Ser Tyr Lys Val Ala Tyr Ser Asn Asp Ser 290 295 300 Ala Asn Trp Thr Glu Tyr Gln Asp Pro Arg Thr Gly Ser Ser Lys Ile 305 310 315 320 Phe Pro Gly Asn Trp Asp Asn His Ser His Lys Lys Asn Leu Phe Glu 325 330 335 Thr Pro Ile Leu Ala Arg Tyr Val Arg Ile Leu Pro Val Ala Trp His 340 345 350 Asn Arg Ile Ala Leu Arg Leu Glu Leu Leu Gly Cys Gly Gly Gly Gly 355 360 365 Thr Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 370 375 380 Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 385 390 395 400 Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 405 410 415 His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 420 425 430 Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 435 440 445 Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 450 455 460 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 465 470 475 480 Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 485 490 495 Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 500 505 510 Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 515 520 525 Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 530 535 540 Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 545 550 555 560 Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 565 570 575 Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 580 585 590 Ser Pro Gly Lys 595 <210> 23 <211> 1788 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 23 ctggacatct gcagcaagaa cccctgccac aacggcggcc tgtgcgaaga gatcagccag 60 gaagtgcggg gcgacgtgtt ccccagctac acctgtacct gcctgaaggg ctacgccggc 120 aaccactgcg agactaagtg cgtggaaccc ctgggcatgg aaaacggcaa tatcgccaac 180 agccagatcg ccgccagctc cgtgcgcgtg acctttctgg gactgcagca ctgggtgccc 240 gagctggcca gactgaacag agccggcatg gtgaacgcct ggacccccag cagcaacgac 300 gacaaccctt ggatccaggt gaacctgctg cggcggatgt gggtgacagg cgtggtgaca 360 cagggcgcca gcagactggc cagccacgag tacctgaagg cctttaaggt ggcctacagc 420 ctgaacggcc acgagttcga cttcatccac gacgtgaaca agaaacacaa agaatttgtg 480 ggcaactgga acaagaacgc cgtgcacgtg aacctgttcg agacacccgt ggaagcccag 540 tacgtgcggc tgtaccccac cagctgccac accgcctgca ccctgagatt cgagctgctg 600 ggctgcgagc tgaacggctg cgccaacccc ctgggcctga agaacaacag catccccgac 660 aagcagatca ccgcctccag cagctacaag acctggggcc tgcacctgtt cagctggaac 720 cccagctacg cccggctgga caagcagggc aacttcaacg cctgggtggc cggcagctac 780 ggcaacgacc agtggctgca ggtggacctg ggcagcagca aagaagtgac cggcatcatc 840 acccaggggg ccagaaactt cggcagcgtg cagttcgtgg ccagctacaa agtggcctac 900 tccaacgaca gcgccaactg gaccgagtac caggaccccc ggaccggcag ctccaagatc 960 ttccccggca actgggacaa ccacagccac aagaagaatc tgttcgaaac ccccatcctg 1020 gccagatacg tgcggatcct gcccgtggcc tggcacaacc ggatcgccct gagactggaa 1080 ctgctgggat gtgggggagg cggtaccgac aagacccaca cctgcccccc ctgcccagcc 1140 ccagagctgc tgggcggacc ctccgtgttc ctgttccccc ccaagcccaa ggacaccctg 1200 atgatcagca ggacccccga ggtgacctgc gtggtggtgg acgtgagcca cgaggaccca 1260 gaggtgaagt tcaactggta cgtggacggc gtggaggtgc acaacgccaa gaccaagccc 1320 agagaggagc agtacaacag cacctacagg gtggtgtccg tgctgaccgt gctgcaccag 1380 gactggctga acggcaagga atacaagtgc aaggtctcca acaaggccct gccagccccc 1440 atcgaaaaga ccatcagcaa ggccaagggc cagccacggg agccccaggt gtacaccctg 1500 cccccctccc gggaggagat gaccaagaac caggtgtccc tgacctgtct ggtgaagggc 1560 ttctacccca gcgacatcgc cgtggagtgg gagagcaacg gccagcccga gaacaactac 1620 aagaccaccc ccccagtgct ggacagcgac ggcagcttct tcctgtacag caagctgacc 1680 gtggacaagt ccaggtggca gcagggcaac gtgttcagct gcagcgtgat gcacgaggcc 1740 ctgcacaacc actacaccca gaagagcctg agcctgtccc ccggcaag 1788 <210> 24 <211> 604 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 24 Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 1 5 10 15 Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 20 25 30 Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 35 40 45 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 50 55 60 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 65 70 75 80 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 85 90 95 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 100 105 110 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 115 120 125 Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 130 135 140 Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 145 150 155 160 Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 165 170 175 Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 180 185 190 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 195 200 205 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 210 215 220 Pro Gly Lys Gly Ser Leu Glu Val Leu Phe Gln Gly Pro Gly Ser Ser 225 230 235 240 Leu Asp Ile Cys Ser Lys Asn Pro Cys His Asn Gly Gly Leu Cys Glu 245 250 255 Glu Ile Ser Gln Glu Val Arg Gly Asp Val Phe Pro Ser Tyr Thr Cys 260 265 270 Thr Cys Leu Lys Gly Tyr Ala Gly Asn His Cys Glu Thr Lys Cys Val 275 280 285 Glu Pro Leu Gly Met Glu Asn Gly Asn Ile Ala Asn Ser Gln Ile Ala 290 295 300 Ala Ser Ser Val Arg Val Thr Phe Leu Gly Leu Gln His Trp Val Pro 305 310 315 320 Glu Leu Ala Arg Leu Asn Arg Ala Gly Met Val Asn Ala Trp Thr Pro 325 330 335 Ser Ser Asn Asp Asp Asn Pro Trp Ile Gln Val Asn Leu Leu Arg Arg 340 345 350 Met Trp Val Thr Gly Val Val Thr Gln Gly Ala Ser Arg Leu Ala Ser 355 360 365 His Glu Tyr Leu Lys Ala Phe Lys Val Ala Tyr Ser Leu Asn Gly His 370 375 380 Glu Phe Asp Phe Ile His Asp Val Asn Lys Lys His Lys Glu Phe Val 385 390 395 400 Gly Asn Trp Asn Lys Asn Ala Val His Val Asn Leu Phe Glu Thr Pro 405 410 415 Val Glu Ala Gln Tyr Val Arg Leu Tyr Pro Thr Ser Cys His Thr Ala 420 425 430 Cys Thr Leu Arg Phe Glu Leu Leu Gly Cys Glu Leu Asn Gly Cys Ala 435 440 445 Asn Pro Leu Gly Leu Lys Asn Asn Ser Ile Pro Asp Lys Gln Ile Thr 450 455 460 Ala Ser Ser Ser Tyr Lys Thr Trp Gly Leu His Leu Phe Ser Trp Asn 465 470 475 480 Pro Ser Tyr Ala Arg Leu Asp Lys Gln Gly Asn Phe Asn Ala Trp Val 485 490 495 Ala Gly Ser Tyr Gly Asn Asp Gln Trp Leu Gln Val Asp Leu Gly Ser 500 505 510 Ser Lys Glu Val Thr Gly Ile Ile Thr Gln Gly Ala Arg Asn Phe Gly 515 520 525 Ser Val Gln Phe Val Ala Ser Tyr Lys Val Ala Tyr Ser Asn Asp Ser 530 535 540 Ala Asn Trp Thr Glu Tyr Gln Asp Pro Arg Thr Gly Ser Ser Lys Ile 545 550 555 560 Phe Pro Gly Asn Trp Asp Asn His Ser His Lys Lys Asn Leu Phe Glu 565 570 575 Thr Pro Ile Leu Ala Arg Tyr Val Arg Ile Leu Pro Val Ala Trp His 580 585 590 Asn Arg Ile Ala Leu Arg Leu Glu Leu Leu Gly Cys 595 600 <210> 25 <211> 1812 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 25 gacaagaccc acacctgtcc cccctgccct gctcctgagc tgctgggagg acccagcgtg 60 ttcctgttcc cccccaagcc caaggacacc ctgatgatca gccggacccc cgaagtgacc 120 tgcgtggtgg tggacgtgtc ccacgaggac cctgaagtga agttcaattg gtacgtggac 180 ggcgtggagg tgcacaacgc caagaccaag ccccgggagg aacagtacaa cagcacctac 240 cgggtggtgt ccgtgctgac cgtgctgcac caggactggc tgaacggcaa agaatacaag 300 tgcaaggtgt ccaacaaggc cctgcctgcc cccatcgaga aaaccatcag caaggccaag 360 ggccagccca gagaacccca ggtgtacaca ctcccaccaa gccgggagga aatgaccaag 420 aaccaggtgt ccctgacctg cctggtgaag ggcttctacc ccagcgacat tgccgtggag 480 tgggagagca acggccagcc tgagaacaac tacaagacca cccctccagt cctcgattct 540 gatggatctt tcttcctgta ctccaagctg accgtggaca agagccggtg gcagcaggga 600 aacgtctttt cctgttccgt catgcatgag gctctccaca atcactacac ccagaagtcc 660 ctgagcctga gccccggcaa gggatccctc gaggtgctgt ttcagggacc aggcagcagc 720 ctggacatct gcagcaagaa cccctgccac aacggcggcc tgtgcgaaga gatcagccag 780 gaagtgcggg gcgacgtgtt ccccagctac acctgtacct gcctgaaggg ctacgccggc 840 aaccactgcg agactaagtg cgtggaaccc ctgggaatgg aaaacggcaa tatcgccaac 900 agccagatcg ccgccagctc cgtcagagtg acctttctgg gactccagca ctgggtgccc 960 gagctggcca gactgaatag agccggcatg gtcaacgcct ggacccccag cagcaacgac 1020 gacaacccct ggattcaagt gaacctgctg cggcgtatgt gggtcaccgg cgtcgtgaca 1080 cagggcgcta gcagactggc cagccacgag tacctgaagg cctttaaggt ggcctacagc 1140 ctgaacggcc acgagttcga cttcatccac gacgtgaaca agaaacacaa agaatttgtg 1200 ggcaactgga acaagaacgc cgtgcacgtg aacctgttcg agacacccgt ggaagcccag 1260 tacgtgcggc tgtaccctac cagctgtcac accgcctgca ccttaagatt cgagctgctg 1320 ggctgcgagc tgaacggctg cgctaatcct ctgggcctga agaacaacag catccccgac 1380 aagcagatca ccgcctccag cagctacaag acctggggac tgcacctgtt cagctggaac 1440 cctagctacg cccggctgga caagcagggc aacttcaatg cttgggtggc cggcagctac 1500 ggcaacgacc agtggctcca ggtggacctg ggcagcagca aagaagtgac cggcatcatc 1560 acccaggggg ccagaaactt cggcagcgtg cagttcgtgg cctcctacaa agtggcctac 1620 tccaacgaca gcgccaactg gaccgagtac caggacccta gaaccggcag ctccaagatt 1680 ttccccggca actgggataa ccacagccac aagaagaatc tgttcgaaac ccccatcctg 1740 gcccgctacg tgcgcattct accggtcgcc tggcacaacc ggatcgccct gagactggaa 1800 ctgctgggat gc 1812 <210> 26 <211> 364 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 26 Leu Asp Ile Cys Ser Lys Asn Pro Cys His Asn Gly Gly Leu Cys Glu 1 5 10 15 Glu Ile Ser Gln Glu Val Arg Gly Asp Val Phe Pro Ser Tyr Thr Cys 20 25 30 Thr Cys Leu Lys Gly Tyr Ala Gly Asn His Cys Glu Thr Lys Gly Cys 35 40 45 Ala Asn Pro Leu Gly Leu Lys Asn Asn Ser Ile Pro Asp Lys Gln Ile 50 55 60 Thr Ala Ser Ser Ser Tyr Lys Thr Trp Gly Leu His Leu Phe Ser Trp 65 70 75 80 Asn Pro Ser Tyr Ala Arg Leu Asp Lys Gln Gly Asn Phe Asn Ala Trp 85 90 95 Val Ala Gly Ser Tyr Gly Asn Asp Gln Trp Leu Gln Val Asp Leu Gly 100 105 110 Ser Ser Lys Glu Val Thr Gly Ile Ile Thr Gln Gly Ala Arg Asn Phe 115 120 125 Gly Ser Val Gln Phe Val Ala Ser Tyr Lys Val Ala Tyr Ser Asn Asp 130 135 140 Ser Ala Asn Trp Thr Glu Tyr Gln Asp Pro Arg Thr Gly Ser Ser Lys 145 150 155 160 Ile Phe Pro Gly Asn Trp Asp Asn His Ser His Lys Lys Asn Leu Phe 165 170 175 Glu Thr Pro Ile Leu Ala Arg Tyr Val Arg Ile Leu Pro Val Ala Trp 180 185 190 His Asn Arg Ile Ala Leu Arg Leu Glu Leu Leu Gly Cys Gly Cys Ala 195 200 205 Asn Pro Leu Gly Leu Lys Asn Asn Ser Ile Pro Asp Lys Gln Ile Thr 210 215 220 Ala Ser Ser Ser Tyr Lys Thr Trp Gly Leu His Leu Phe Ser Trp Asn 225 230 235 240 Pro Ser Tyr Ala Arg Leu Asp Lys Gln Gly Asn Phe Asn Ala Trp Val 245 250 255 Ala Gly Ser Tyr Gly Asn Asp Gln Trp Leu Gln Val Asp Leu Gly Ser 260 265 270 Ser Lys Glu Val Thr Gly Ile Ile Thr Gln Gly Ala Arg Asn Phe Gly 275 280 285 Ser Val Gln Phe Val Ala Ser Tyr Lys Val Ala Tyr Ser Asn Asp Ser 290 295 300 Ala Asn Trp Thr Glu Tyr Gln Asp Pro Arg Thr Gly Ser Ser Lys Ile 305 310 315 320 Phe Pro Gly Asn Trp Asp Asn His Ser His Lys Lys Asn Leu Phe Glu 325 330 335 Thr Pro Ile Leu Ala Arg Tyr Val Arg Ile Leu Pro Val Ala Trp His 340 345 350 Asn Arg Ile Ala Leu Arg Leu Glu Leu Leu Gly Cys 355 360 <210> 27 <211> 1092 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 27 ctggacatct gcagcaagaa cccctgccac aacggcggcc tgtgcgaaga gatcagccag 60 gaagtgcggg gcgacgtgtt ccccagctac acctgtacct gcctgaaggg ctacgccggc 120 aaccactgcg agacaaaggg ctgcgccaac cccctgggcc tgaagaacaa cagcatcccc 180 gacaagcaga tcaccgccag cagcagctac aagacctggg gcctgcacct gttcagctgg 240 aaccccagct acgcccggct ggacaagcag ggcaacttca acgcctgggt ggccggcagc 300 tacggcaacg accagtggct gcaggtggac ctgggcagca gcaaagaagt gaccggcatc 360 atcacccagg gcgccagaaa cttcggcagc gtgcagttcg tggccagcta caaggtggcc 420 tacagcaacg acagcgccaa ctggaccgag taccaggacc cccggaccgg cagctccaag 480 atcttccccg gcaactggga caaccacagc cacaagaaga acctgttcga gacacccatc 540 ctggccagat acgtgcggat cctgcccgtg gcctggcaca accggatcgc cctgagactg 600 gaactgctgg gctgcggctg tgccaatcct ctgggactga aaaacaattc catccctgat 660 aagcagatta cagcctccag ctcctataag acatgggggc tgcatctgtt ttcttggaac 720 ccctcctacg ctagactgga taagcaggga aatttcaatg cttgggtggc cgggtcctat 780 ggaaatgatc agtggctgca ggtggacctg ggatcctcca aagaagtgac agggattatt 840 acacaggggg ctcggaactt tggctctgtg cagtttgtgg cttcctacaa agtggcttac 900 tccaacgatt ccgccaattg gacagaatat caggatccca gaaccggctc cagcaagatc 960 tttcctggaa attgggataa tcactcccac aagaaaaatc tgtttgaaac ccctattctg 1020 gctcgctatg tgcgcattct gcctgtggct tggcataata gaatcgctct gcggctggaa 1080 ctgctgggat gc 1092 <210> 28 <211> 967 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 28 Leu Asp Ile Cys Ser Lys Asn Pro Cys His Asn Gly Gly Leu Cys Glu 1 5 10 15 Glu Ile Ser Gln Glu Val Arg Gly Asp Val Phe Pro Ser Tyr Thr Cys 20 25 30 Thr Cys Leu Lys Gly Tyr Ala Gly Asn His Cys Glu Thr Lys Cys Val 35 40 45 Glu Pro Leu Gly Met Glu Asn Gly Asn Ile Ala Asn Ser Gln Ile Ala 50 55 60 Ala Ser Ser Val Arg Val Thr Phe Leu Gly Leu Gln His Trp Val Pro 65 70 75 80 Glu Leu Ala Arg Leu Asn Arg Ala Gly Met Val Asn Ala Trp Thr Pro 85 90 95 Ser Ser Asn Asp Asp Asn Pro Trp Ile Gln Val Asn Leu Leu Arg Arg 100 105 110 Met Trp Val Thr Gly Val Val Thr Gln Gly Ala Ser Arg Leu Ala Ser 115 120 125 His Glu Tyr Leu Lys Ala Phe Lys Val Ala Tyr Ser Leu Asn Gly His 130 135 140 Glu Phe Asp Phe Ile His Asp Val Asn Lys Lys His Lys Glu Phe Val 145 150 155 160 Gly Asn Trp Asn Lys Asn Ala Val His Val Asn Leu Phe Glu Thr Pro 165 170 175 Val Glu Ala Gln Tyr Val Arg Leu Tyr Pro Thr Ser Cys His Thr Ala 180 185 190 Cys Thr Leu Arg Phe Glu Leu Leu Gly Cys Glu Leu Asn Gly Cys Ala 195 200 205 Asn Pro Leu Gly Leu Lys Asn Asn Ser Ile Pro Asp Lys Gln Ile Thr 210 215 220 Ala Ser Ser Ser Tyr Lys Thr Trp Gly Leu His Leu Phe Ser Trp Asn 225 230 235 240 Pro Ser Tyr Ala Arg Leu Asp Lys Gln Gly Asn Phe Asn Ala Trp Val 245 250 255 Ala Gly Ser Tyr Gly Asn Asp Gln Trp Leu Gln Val Asp Leu Gly Ser 260 265 270 Ser Lys Glu Val Thr Gly Ile Ile Thr Gln Gly Ala Arg Asn Phe Gly 275 280 285 Ser Val Gln Phe Val Ala Ser Tyr Lys Val Ala Tyr Ser Asn Asp Ser 290 295 300 Ala Asn Trp Thr Glu Tyr Gln Asp Pro Arg Thr Gly Ser Ser Lys Ile 305 310 315 320 Phe Pro Gly Asn Trp Asp Asn His Ser His Lys Lys Asn Leu Phe Glu 325 330 335 Thr Pro Ile Leu Ala Arg Tyr Val Arg Ile Leu Pro Val Ala Trp His 340 345 350 Asn Arg Ile Ala Leu Arg Leu Glu Leu Leu Gly Cys Gly Gly Ser Gly 355 360 365 Gly Ser Gly Gly Ser Gly Gly Ser Asp Ala His Lys Ser Glu Val Ala 370 375 380 His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 385 390 395 400 Ile Ala Phe Ala Gln Tyr Leu Gln Gln Ser Pro Phe Glu Asp His Val 405 410 415 Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 420 425 430 Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 435 440 445 Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 450 455 460 Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 465 470 475 480 His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 485 490 495 Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 500 505 510 Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 515 520 525 Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys 530 535 540 Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu 545 550 555 560 Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys 565 570 575 Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 580 585 590 Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser 595 600 605 Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly 610 615 620 Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 625 630 635 640 Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 645 650 655 Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp 660 665 670 Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser 675 680 685 Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 690 695 700 Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val 705 710 715 720 Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys 725 730 735 Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu 740 745 750 Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys 755 760 765 Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu 770 775 780 Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val 785 790 795 800 Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His 805 810 815 Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val 820 825 830 Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg 835 840 845 Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe 850 855 860 Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala 865 870 875 880 Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu 885 890 895 Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys 900 905 910 Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala 915 920 925 Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe 930 935 940 Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly 945 950 955 960 Leu His His His His His His 965 <210> 29 <211> 2901 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 29 ctggacatct gcagcaagaa cccctgccac aacggcggcc tgtgcgaaga gatcagccag 60 gaagtgcggg gcgacgtgtt ccccagctac acctgtacct gcctgaaggg ctacgccggc 120 aaccactgcg agactaagtg cgtggaaccc ctgggcatgg aaaacggcaa tatcgccaac 180 agccagatcg ccgccagctc cgtgcgcgtg acctttctgg gactgcagca ctgggtgccc 240 gagctggcca gactgaacag agccggcatg gtgaacgcct ggacccccag cagcaacgac 300 gacaaccctt ggatccaggt gaacctgctg cggcggatgt gggtgacagg cgtggtgaca 360 cagggcgcca gcagactggc cagccacgag tacctgaagg cctttaaggt ggcctacagc 420 ctgaacggcc acgagttcga cttcatccac gacgtgaaca agaaacacaa agaatttgtg 480 ggcaactgga acaagaacgc cgtgcacgtg aacctgttcg agacacccgt ggaagcccag 540 tacgtgcggc tgtaccccac cagctgccac accgcctgca ccctgagatt cgagctgctg 600 ggctgcgagc tgaacggctg cgccaacccc ctgggcctga agaacaacag catccccgac 660 aagcagatca ccgcctccag cagctacaag acctggggcc tgcacctgtt cagctggaac 720 cccagctacg cccggctgga caagcagggc aacttcaacg cctgggtggc cggcagctac 780 ggcaacgacc agtggctgca ggtggacctg ggcagcagca aagaagtgac cggcatcatc 840 acccaggggg ccagaaactt cggcagcgtg cagttcgtgg ccagctacaa agtggcctac 900 tccaacgaca gcgccaactg gaccgagtac caggaccccc ggaccggcag ctccaagatc 960 ttccccggca actgggacaa ccacagccac aagaagaatc tgttcgaaac ccccatcctg 1020 gccagatacg tgcggatcct gcccgtggcc tggcacaacc ggatcgccct gagactggaa 1080 ctgctgggat gtggaggaag cggaggatct ggcggttccg gaggctctga cgcccacaag 1140 agcgaggtgg cccaccggtt caaggacctg ggcgaggaaa acttcaaggc cctggtgctg 1200 atcgccttcg cccagtacct gcagcagagc cccttcgaag atcacgtaaa gttagtcaac 1260 gaggttacgg aattcgcaaa gacatgcgtt gctgacgaat ccgctgagaa ttgtgacaag 1320 agtttgcaca ctttattcgg agataagttg tgtactgtag ctactttgag agagacttac 1380 ggtgaaatgg ctgactgctg tgcaaaacag gaaccagaac gtaacgaatg tttccttcag 1440 cataaggatg ataaccctaa ccttccaagg cttgttaggc cagaagtcga cgtgatgtgc 1500 accgccttcc atgataatga agagactttt cttaaaaagt acctatacga gattgcaagg 1560 cgtcatccat atttttacgc cccagagctg ttgtttttcg caaagagata caaagctgca 1620 tttactgagt gttgccaagc tgccgacaag gccgcttgtt tgctaccaaa gttggacgaa 1680 ttgagagacg agggtaaggc atcatctgcc aagcagagat taaaatgtgc atctttgcaa 1740 aaatttggag agagagcttt taaggcatgg gctgttgccc gactaagcca aagattccca 1800 aaagccgaat ttgctgaagt atccaagctg gtgactgatt tgactaaagt acatacagaa 1860 tgttgccatg gcgacctttt agaatgtgct gatgacagag cagatttggc taagtatatc 1920 tgcgaaaatc aagattcaat cagctctaag ctgaaggaat gttgcgagaa accactgtta 1980 gaaaaatcgc attgtattgc tgaagttgaa aatgatgaga tgcctgctga cttgccttct 2040 cttgccgctg attttgttga gtcgaaggat gtctgtaaga attatgctga agctaaagac 2100 gttttcctgg gtatgttctt atatgagtac gcaagacgtc acccagatta ctctgtggtt 2160 ctgctactga gattggctaa aacatacgag acaacgctgg agaagtgctg tgctgccgct 2220 gaccctcatg agtgctatgc aaaggttttt gatgaattca aaccattggt tgaagagcct 2280 caaaacttga taaagcagaa ctgtgagctg tttgagcaat tgggtgagta taagttccaa 2340 aatgccctgt tggtgagata tacaaaaaag gtaccccaag tttcaacgcc cactttagtt 2400 gaagtgtcca gaaatcttgg taaagtgggt agcaaatgtt gcaagcatcc agaagccaag 2460 cgaatgccct gtgctgagga ttatctgtcc gtcgtgttga accaattgtg cgtattacac 2520 gaaaaaaccc cagtctctga tagagtcacc aaatgttgca ctgagtcact agttaataga 2580 aggccttgtt tttccgcttt ggaagttgat gaaacctacg tgcctaagga atttaacgct 2640 gagaccttta cctttcacgc tgacatttgt actttgagtg aaaaagagcg tcaaatcaaa 2700 aagcaaaccg ctcttgttga attggtgaaa cacaagccta aggctacgaa ggagcagctt 2760 aaagccgtca tggacgattt cgccgcattt gttgaaaaat gctgtaaagc tgatgacaag 2820 gaaacatgtt tcgctgaaga gggaaagaaa ttggttgcgg ccagtcaggc cgcacttggt 2880 ttgcaccatc atcaccatca c 2901 <210> 30 <211> 965 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 30 Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 1 5 10 15 Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 20 25 30 Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 35 40 45 Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 50 55 60 Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 65 70 75 80 Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 85 90 95 Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 100 105 110 Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 115 120 125 Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 130 135 140 Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 145 150 155 160 Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 165 170 175 Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 180 185 190 Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 195 200 205 Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 210 215 220 Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 225 230 235 240 Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 245 250 255 Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 260 265 270 Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 275 280 285 Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 290 295 300 Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 305 310 315 320 Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 325 330 335 Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 340 345 350 Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 355 360 365 Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 370 375 380 Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 385 390 395 400 Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 405 410 415 Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 420 425 430 Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 435 440 445 Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 450 455 460 Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 465 470 475 480 Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 485 490 495 Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 500 505 510 Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 515 520 525 Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 530 535 540 Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 545 550 555 560 Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 565 570 575 Ala Ala Ser Gln Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 580 585 590 Ser Leu Asp Ile Cys Ser Lys Asn Pro Cys His Asn Gly Gly Leu Cys 595 600 605 Glu Glu Ile Ser Gln Glu Val Arg Gly Asp Val Phe Pro Ser Tyr Thr 610 615 620 Cys Thr Cys Leu Lys Gly Tyr Ala Gly Asn His Cys Glu Thr Lys Cys 625 630 635 640 Val Glu Pro Leu Gly Met Glu Asn Gly Asn Ile Ala Asn Ser Gln Ile 645 650 655 Ala Ala Ser Ser Val Arg Val Thr Phe Leu Gly Leu Gln His Trp Val 660 665 670 Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly Met Val Asn Ala Trp Thr 675 680 685 Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile Gln Val Asn Leu Leu Arg 690 695 700 Arg Met Trp Val Thr Gly Val Val Thr Gln Gly Ala Ser Arg Leu Ala 705 710 715 720 Ser His Glu Tyr Leu Lys Ala Phe Lys Val Ala Tyr Ser Leu Asn Gly 725 730 735 His Glu Phe Asp Phe Ile His Asp Val Asn Lys Lys His Lys Glu Phe 740 745 750 Val Gly Asn Trp Asn Lys Asn Ala Val His Val Asn Leu Phe Glu Thr 755 760 765 Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr Pro Thr Ser Cys His Thr 770 775 780 Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly Cys Glu Leu Asn Gly Cys 785 790 795 800 Ala Asn Pro Leu Gly Leu Lys Asn Asn Ser Ile Pro Asp Lys Gln Ile 805 810 815 Thr Ala Ser Ser Ser Tyr Lys Thr Trp Gly Leu His Leu Phe Ser Trp 820 825 830 Asn Pro Ser Tyr Ala Arg Leu Asp Lys Gln Gly Asn Phe Asn Ala Trp 835 840 845 Val Ala Gly Ser Tyr Gly Asn Asp Gln Trp Leu Gln Val Asp Leu Gly 850 855 860 Ser Ser Lys Glu Val Thr Gly Ile Ile Thr Gln Gly Ala Arg Asn Phe 865 870 875 880 Gly Ser Val Gln Phe Val Ala Ser Tyr Lys Val Ala Tyr Ser Asn Asp 885 890 895 Ser Ala Asn Trp Thr Glu Tyr Gln Asp Pro Arg Thr Gly Ser Ser Lys 900 905 910 Ile Phe Pro Gly Asn Trp Asp Asn His Ser His Lys Lys Asn Leu Phe 915 920 925 Glu Thr Pro Ile Leu Ala Arg Tyr Val Arg Ile Leu Pro Val Ala Trp 930 935 940 His Asn Arg Ile Ala Leu Arg Leu Glu Leu Leu Gly Cys Gly Ser His 945 950 955 960 His His His His His 965 <210> 31 <211> 2895 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 31 gacgcccaca agagcgaggt ggcccaccgg ttcaaggacc tgggcgagga aaacttcaag 60 gccctggtgc tgatcgcctt cgcccagtac ctgcagcaga gccccttcga agatcacgta 120 aagttagtca acgaggttac ggaattcgca aagacatgcg ttgctgacga atccgctgag 180 aattgtgaca agagtttgca cactttattc ggagataagt tgtgtactgt agctactttg 240 agagagactt acggtgaaat ggctgactgc tgtgcaaaac aggaaccaga acgtaacgaa 300 tgtttccttc agcataagga tgataaccct aaccttccaa ggcttgttag gccagaagtc 360 gacgtgatgt gcaccgcctt ccatgataat gaagagactt ttcttaaaaa gtacctatac 420 gagattgcaa ggcgtcatcc atatttttac gccccagagc tgttgttttt cgcaaagaga 480 tacaaagctg catttactga gtgttgccaa gctgccgaca aggccgcttg tttgctacca 540 aagttggacg aattgagaga cgagggtaag gcatcatctg ccaagcagag attaaaatgt 600 gcatctttgc aaaaatttgg agagagagct tttaaggcat gggctgttgc ccgactaagc 660 caaagattcc caaaagccga atttgctgaa gtatccaagc tggtgactga tttgactaaa 720 gtacatacag aatgttgcca tggcgacctt ttagaatgtg ctgatgacag agcagatttg 780 gctaagtata tctgcgaaaa tcaagattca atcagctcta agctgaagga atgttgcgag 840 aaaccactgt tagaaaaatc gcattgtatt gctgaagttg aaaatgatga gatgcctgct 900 gacttgcctt ctcttgccgc tgattttgtt gagtcgaagg atgtctgtaa gaattatgct 960 gaagctaaag acgttttcct gggtatgttc ttatatgagt acgcaagacg tcacccagat 1020 tactctgtgg ttctgctact gagattggct aaaacatacg agacaacgct ggagaagtgc 1080 tgtgctgccg ctgaccctca tgagtgctat gcaaaggttt ttgatgaatt caaaccattg 1140 gttgaagagc ctcaaaactt gataaagcag aactgtgagc tgtttgagca attgggtgag 1200 tataagttcc aaaatgccct gttggtgaga tatacaaaaa aggtacccca agtttcaacg 1260 cccactttag ttgaagtgtc cagaaatctt ggtaaagtgg gtagcaaatg ttgcaagcat 1320 ccagaagcca agcgaatgcc ctgtgctgag gattatctgt ccgtcgtgtt gaaccaattg 1380 tgcgtattac acgaaaaaac cccagtctct gatagagtca ccaaatgttg cactgagtca 1440 ctagttaata gaaggccttg tttttccgct ttggaagttg atgaaaccta cgtgcctaag 1500 gaatttaacg ctgagacctt tacctttcac gctgacattt gtactttgag tgaaaaagag 1560 cgtcaaatca aaaagcaaac cgctcttgtt gaattggtga aacacaagcc taaggctacg 1620 aaggagcagc ttaaagccgt catggacgat ttcgccgcat ttgttgaaaa atgctgtaaa 1680 gctgatgaca aggaaacatg tttcgctgaa gagggaaaga aattggttgc ggccagtcag 1740 gccggaggaa gcggaggatc tggcggttcc ggaggctctc tagacatctg cagcaagaac 1800 ccctgccaca acggcggcct gtgcgaagag atcagccagg aagtgcgggg cgacgtgttc 1860 cccagctaca cctgtacctg cctgaagggc tacgccggca accactgcga gactaagtgc 1920 gtggaacccc tgggcatgga aaacggcaat atcgccaaca gccagatcgc cgccagctcc 1980 gtgcgcgtga cctttctggg actgcagcac tgggtgcccg agctggccag actgaacaga 2040 gccggcatgg tgaacgcctg gacccccagc agcaacgacg acaacccttg gatccaggtg 2100 aacctgctgc ggcggatgtg ggtgacaggc gtggtgacac agggcgccag cagactggcc 2160 agccacgagt acctgaaggc ctttaaggtg gcctacagcc tgaacggcca cgagttcgac 2220 ttcatccacg acgtgaacaa gaaacacaaa gaatttgtgg gcaactggaa caagaacgcc 2280 gtgcacgtga acctgttcga gacacccgtg gaagcccagt acgtgcggct gtaccccacc 2340 agctgccaca ccgcctgcac cctgagattc gagctgctgg gctgcgagct gaacggctgc 2400 gccaaccccc tgggcctgaa gaacaacagc atccccgaca agcagatcac cgcctccagc 2460 agctacaaga cctggggcct gcacctgttc agctggaacc ccagctacgc ccggctggac 2520 aagcagggca acttcaacgc ctgggtggcc ggcagctacg gcaacgacca gtggctgcag 2580 gtggacctgg gcagcagcaa agaagtgacc ggcatcatca cccagggggc cagaaacttc 2640 ggcagcgtgc agttcgtggc cagctacaaa gtggcctact ccaacgacag cgccaactgg 2700 accgagtacc aggacccccg gaccggcagc tccaagatct tccccggcaa ctgggacaac 2760 cacagccaca agaagaatct gttcgaaacc cccatcctgg ccagatacgt gcggatcctg 2820 cccgtggcct ggcacaaccg gatcgccctg agactggaac tgctgggatg tggctctcac 2880 caccaccatc accat 2895 <210> 32 <211> 641 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 32 Leu Asp Ile Cys Ser Lys Asn Pro Cys His Asn Gly Gly Leu Cys Glu 1 5 10 15 Glu Ile Ser Gln Glu Val Arg Gly Asp Val Phe Pro Ser Tyr Thr Cys 20 25 30 Thr Cys Leu Lys Gly Tyr Ala Gly Asn His Cys Glu Thr Lys Gly Ser 35 40 45 Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 50 55 60 Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 65 70 75 80 Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 85 90 95 Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 100 105 110 Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 115 120 125 Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 130 135 140 Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 145 150 155 160 Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 165 170 175 Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 180 185 190 Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 195 200 205 Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 210 215 220 Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 225 230 235 240 Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 245 250 255 Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 260 265 270 Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 275 280 285 Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 290 295 300 Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 305 310 315 320 Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 325 330 335 Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 340 345 350 Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 355 360 365 Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 370 375 380 Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 385 390 395 400 Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 405 410 415 Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 420 425 430 Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 435 440 445 Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 450 455 460 Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 465 470 475 480 Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 485 490 495 Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 500 505 510 Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 515 520 525 Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 530 535 540 Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 545 550 555 560 Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 565 570 575 Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 580 585 590 Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 595 600 605 Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 610 615 620 Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Ser His His His His His 625 630 635 640 His <210> 33 <211> 1923 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 33 ctggacatct gcagcaagaa tccttgccac aacggcggcc tgtgcgaaga gatttctcaa 60 gaagtgcggg gcgacgtttt ccccagctac acctgtacat gtctgaaggg ctacgccggc 120 aaccactgcg agacaaaagg atccgatgct cacaagagcg aggtggccca cagattcaag 180 gatctgggcg aagagaactt caaggccctg gtgctgatcg ccttcgctca gtatctccag 240 cagagccctt tcgaggacca cgtgaagctg gtcaacgaag tgaccgagtt cgccaagacc 300 tgtgtggccg atgagagcgc cgagaactgt gataagagcc tgcacaccct gttcggcgac 360 aagctgtgta cagtggccac actgagagaa acctacggcg agatggccga ctgctgtgcc 420 aagcaagagc ccgagagaaa cgagtgcttc ctgcagcaca aggacgacaa ccccaacctg 480 cctagactcg tgcgacccga agtggatgtg atgtgcaccg cctttcacga caacgaggaa 540 accttcctga agaagtacct gtacgagatc gccagacggc acccctactt ttatgcccct 600 gagctgctgt tcttcgccaa gcggtataag gccgccttca ccgaatgttg ccaggccgct 660 gataaggctg cctgtctgct gcctaagctg gacgagctga gagatgaggg caaagccagc 720 tctgccaagc agagactgaa gtgcgccagc ctgcagaagt tcggcgagag agcttttaag 780 gcctgggccg ttgccagact gagccagaga tttcctaagg ccgagtttgc cgaggtgtcc 840 aagctcgtga ccgatctgac aaaggtgcac accgagtgct gtcacggcga tctgctggaa 900 tgtgccgacg atagagccga cctggccaag tacatctgcg agaaccagga cagcatcagc 960 agcaagctga aagagtgctg cgagaagccc ctgctggaaa agtctcactg tatcgccgag 1020 gtggaaaacg acgagatgcc tgccgatctg cctagcctgg ctgccgattt cgtggaaagc 1080 aaggacgtgt gcaagaacta cgccgaggcc aaggatgtgt ttctgggcat gtttctgtat 1140 gagtacgccc gcagacaccc cgactattct gtggttctgc tgctgcggct ggccaaaacc 1200 tacgagacaa ccctggaaaa atgctgcgcc gctgccgatc ctcacgagtg ttatgccaag 1260 gtgttcgacg agttcaagcc tctggtggaa gaaccccaga acctgatcaa gcagaactgc 1320 gagctgttcg agcagctggg cgagtacaag ttccagaatg ccctgctcgt gcggtacacc 1380 aagaaagtgc ctcaggtgtc cacacctaca ctggttgagg tgtcccggaa tctgggcaaa 1440 gtgggcagca agtgttgcaa gcaccctgag gccaagagaa tgccttgcgc cgaggattac 1500 ctgagcgtgg tgctgaatca gctgtgcgtg ctgcacgaga aaacccctgt gtccgacaga 1560 gtgaccaagt gctgtaccga gagcctcgtg aacagaaggc cttgctttag cgccctggaa 1620 gtggacgaga catacgtgcc caaagagttc aacgccgaga cattcacctt ccacgccgac 1680 atctgtaccc tgagcgagaa agagcggcag atcaagaagc agacagccct ggtcgagctg 1740 gttaagcaca agcccaaggc caccaaagaa cagctgaagg ccgtgatgga cgacttcgcc 1800 gcctttgtcg agaagtgctg caaggccgac gacaaagaga catgcttcgc cgaagagggc 1860 aagaaactgg tggctgcctc tcaggctgct ctcggacttg gctctcacca ccaccatcac 1920 cat 1923 <210> 34 <211> 809 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 34 Leu Asp Ile Cys Ser Lys Asn Pro Cys His Asn Gly Gly Leu Cys Glu 1 5 10 15 Glu Ile Ser Gln Glu Val Arg Gly Asp Val Phe Pro Ser Tyr Thr Cys 20 25 30 Thr Cys Leu Lys Gly Tyr Ala Gly Asn His Cys Glu Thr Lys Gly Ser 35 40 45 Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 50 55 60 Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 65 70 75 80 Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 85 90 95 Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 100 105 110 Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 115 120 125 Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 130 135 140 Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 145 150 155 160 Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 165 170 175 Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 180 185 190 Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 195 200 205 Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 210 215 220 Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 225 230 235 240 Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 245 250 255 Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 260 265 270 Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 275 280 285 Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 290 295 300 Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 305 310 315 320 Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 325 330 335 Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 340 345 350 Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 355 360 365 Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 370 375 380 Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 385 390 395 400 Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 405 410 415 Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 420 425 430 Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 435 440 445 Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 450 455 460 Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 465 470 475 480 Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 485 490 495 Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 500 505 510 Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 515 520 525 Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 530 535 540 Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 545 550 555 560 Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 565 570 575 Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 580 585 590 Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 595 600 605 Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 610 615 620 Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Ser Gly Gly Ser Gly 625 630 635 640 Gly Ser Gly Gly Ser Cys Val Glu Pro Leu Gly Met Glu Asn Gly Asn 645 650 655 Ile Ala Asn Ser Gln Ile Ala Ala Ser Ser Val Arg Val Thr Phe Leu 660 665 670 Gly Leu Gln His Trp Val Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly 675 680 685 Met Val Asn Ala Trp Thr Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile 690 695 700 Gln Val Asn Leu Leu Arg Arg Met Trp Val Thr Gly Val Val Thr Gln 705 710 715 720 Gly Ala Ser Arg Leu Ala Ser His Glu Tyr Leu Lys Ala Phe Lys Val 725 730 735 Ala Tyr Ser Leu Asn Gly His Glu Phe Asp Phe Ile His Asp Val Asn 740 745 750 Lys Lys His Lys Glu Phe Val Gly Asn Trp Asn Lys Asn Ala Val His 755 760 765 Val Asn Leu Phe Glu Thr Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr 770 775 780 Pro Thr Ser Cys His Thr Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly 785 790 795 800 Cys Gly Ser His His His His His His 805 <210> 35 <211> 2427 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 35 ctggacatct gcagcaagaa tccttgccac aacggcggcc tgtgcgaaga gatttctcaa 60 gaagtgcggg gcgacgtttt ccccagctac acctgtacat gtctgaaggg ctacgccggc 120 aaccactgcg agacaaaagg atccgatgct cacaagagcg aggtggccca cagattcaag 180 gatctgggcg aagagaactt caaggccctg gtgctgatcg ccttcgctca gtatctccag 240 cagagccctt tcgaggacca cgtgaagctg gtcaacgaag tgaccgagtt cgccaagacc 300 tgtgtggccg atgagagcgc cgagaactgt gataagagcc tgcacaccct gttcggcgac 360 aagctgtgta cagtggccac actgagagaa acctacggcg agatggccga ctgctgtgcc 420 aagcaagagc ccgagagaaa cgagtgcttc ctgcagcaca aggacgacaa ccccaacctg 480 cctagactcg tgcgacccga agtggatgtg atgtgcaccg cctttcacga caacgaggaa 540 accttcctga agaagtacct gtacgagatc gccagacggc acccctactt ttatgcccct 600 gagctgctgt tcttcgccaa gcggtataag gccgccttca ccgaatgttg ccaggccgct 660 gataaggctg cctgtctgct gcctaagctg gacgagctga gagatgaggg caaagccagc 720 tctgccaagc agagactgaa gtgcgccagc ctgcagaagt tcggcgagag agcttttaag 780 gcctgggccg ttgccagact gagccagaga tttcctaagg ccgagtttgc cgaggtgtcc 840 aagctcgtga ccgatctgac aaaggtgcac accgagtgct gtcacggcga tctgctggaa 900 tgtgccgacg atagagccga cctggccaag tacatctgcg agaaccagga cagcatcagc 960 agcaagctga aagagtgctg cgagaagccc ctgctggaaa agtctcactg tatcgccgag 1020 gtggaaaacg acgagatgcc tgccgatctg cctagcctgg ctgccgattt cgtggaaagc 1080 aaggacgtgt gcaagaacta cgccgaggcc aaggatgtgt ttctgggcat gtttctgtat 1140 gagtacgccc gcagacaccc cgactattct gtggttctgc tgctgcggct ggccaaaacc 1200 tacgagacaa ccctggaaaa atgctgcgcc gctgccgatc ctcacgagtg ttatgccaag 1260 gtgttcgacg agttcaagcc tctggtggaa gaaccccaga acctgatcaa gcagaactgc 1320 gagctgttcg agcagctggg cgagtacaag ttccagaatg ccctgctcgt gcggtacacc 1380 aagaaagtgc ctcaggtgtc cacacctaca ctggttgagg tgtcccggaa tctgggcaaa 1440 gtgggcagca agtgttgcaa gcaccctgag gccaagagaa tgccttgcgc cgaggattac 1500 ctgagcgtgg tgctgaatca gctgtgcgtg ctgcacgaga aaacccctgt gtccgacaga 1560 gtgaccaagt gctgtaccga gagcctcgtg aacagaaggc cttgctttag cgccctggaa 1620 gtggacgaga catacgtgcc caaagagttc aacgccgaga cattcacctt ccacgccgac 1680 atctgtaccc tgagcgagaa agagcggcag atcaagaagc agacagccct ggtcgagctg 1740 gttaagcaca agcccaaggc caccaaagaa cagctgaagg ccgtgatgga cgacttcgcc 1800 gcctttgtcg agaagtgctg caaggccgac gacaaagaga catgcttcgc cgaagagggc 1860 aagaaactgg tggctgcctc tcaggctgct ctcggacttg gaggaagcgg aggatctggc 1920 ggttccggag gctcttgtgt ggaacccctc ggcatggaaa acggcaatat cgccaatagc 1980 cagattgccg ccagcagcgt cagagtgaca tttctgggac tgcagcactg ggtgcccgag 2040 ctggctagac tgaatagagc cggcatggtc aacgcctgga cacccagcag caacgacgat 2100 aacccttgga ttcaagtgaa cctgctgcgg cgtatgtggg tcacaggtgt tgttacacag 2160 ggcgcctcta gactggccag ccacgagtat ctgaaggcct ttaaggtggc ctacagcctg 2220 aacggccacg agttcgactt catccacgac gtgaacaaga agcacaaaga gtttgtcggc 2280 aactggaaca agaacgccgt gcacgtgaac ctgttcgaga cacctgtgga agcccagtac 2340 gtgcggctgt accctacaag ctgtcacacc gcctgcactc tgagattcga actgctggga 2400 tgcggctctc accaccacca tcaccat 2427 <210> 36 <211> 811 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 36 Leu Asp Ile Cys Ser Lys Asn Pro Cys His Asn Gly Gly Leu Cys Glu 1 5 10 15 Glu Ile Ser Gln Glu Val Arg Gly Asp Val Phe Pro Ser Tyr Thr Cys 20 25 30 Thr Cys Leu Lys Gly Tyr Ala Gly Asn His Cys Glu Thr Lys Gly Ser 35 40 45 Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 50 55 60 Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 65 70 75 80 Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 85 90 95 Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 100 105 110 Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 115 120 125 Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 130 135 140 Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 145 150 155 160 Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 165 170 175 Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 180 185 190 Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 195 200 205 Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 210 215 220 Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 225 230 235 240 Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 245 250 255 Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 260 265 270 Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 275 280 285 Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 290 295 300 Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 305 310 315 320 Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 325 330 335 Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 340 345 350 Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 355 360 365 Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 370 375 380 Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 385 390 395 400 Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 405 410 415 Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 420 425 430 Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 435 440 445 Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 450 455 460 Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 465 470 475 480 Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 485 490 495 Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 500 505 510 Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 515 520 525 Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 530 535 540 Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 545 550 555 560 Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 565 570 575 Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 580 585 590 Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 595 600 605 Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 610 615 620 Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Ser Gly Gly Ser Gly 625 630 635 640 Gly Ser Gly Gly Ser Cys Ala Asn Pro Leu Gly Leu Lys Asn Asn Ser 645 650 655 Ile Pro Asp Lys Gln Ile Thr Ala Ser Ser Ser Tyr Lys Thr Trp Gly 660 665 670 Leu His Leu Phe Ser Trp Asn Pro Ser Tyr Ala Arg Leu Asp Lys Gln 675 680 685 Gly Asn Phe Asn Ala Trp Val Ala Gly Ser Tyr Gly Asn Asp Gln Trp 690 695 700 Leu Gln Val Asp Leu Gly Ser Ser Lys Glu Val Thr Gly Ile Ile Thr 705 710 715 720 Gln Gly Ala Arg Asn Phe Gly Ser Val Gln Phe Val Ala Ser Tyr Lys 725 730 735 Val Ala Tyr Ser Asn Asp Ser Ala Asn Trp Thr Glu Tyr Gln Asp Pro 740 745 750 Arg Thr Gly Ser Ser Lys Ile Phe Pro Gly Asn Trp Asp Asn His Ser 755 760 765 His Lys Lys Asn Leu Phe Glu Thr Pro Ile Leu Ala Arg Tyr Val Arg 770 775 780 Ile Leu Pro Val Ala Trp His Asn Arg Ile Ala Leu Arg Leu Glu Leu 785 790 795 800 Leu Gly Cys Gly Ser His His His His His His 805 810 <210> 37 <211> 2433 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 37 ctggacatct gcagcaagaa tccttgccac aacggcggcc tgtgcgaaga gatttctcaa 60 gaagtgcggg gcgacgtttt ccccagctac acctgtacat gtctgaaggg ctacgccggc 120 aaccactgcg agacaaaagg atccgacgcc cacaagagcg aggtggccca ccggttcaag 180 gacctgggcg aggaaaactt caaggccctg gtgctgatcg ccttcgccca gtacctgcag 240 cagagcccct tcgaagatca cgtaaagtta gtcaacgagg ttacggaatt cgcaaagaca 300 tgcgttgctg acgaatccgc tgagaattgt gacaagagtt tgcacacttt attcggagat 360 aagttgtgta ctgtagctac tttgagagag acttacggtg aaatggctga ctgctgtgca 420 aaacaggaac cagaacgtaa cgaatgtttc cttcagcata aggatgataa ccctaacctt 480 ccaaggcttg ttaggccaga agtcgacgtg atgtgcaccg ccttccatga taatgaagag 540 acttttctta aaaagtacct atacgagatt gcaaggcgtc atccatattt ttacgcccca 600 gagctgttgt ttttcgcaaa gagatacaaa gctgcattta ctgagtgttg ccaagctgcc 660 gacaaggccg cttgtttgct accaaagttg gacgaattga gagacgaggg taaggcatca 720 tctgccaagc agagattaaa atgtgcatct ttgcaaaaat ttggagagag agcttttaag 780 gcatgggctg ttgcccgact aagccaaaga ttcccaaaag ccgaatttgc tgaagtatcc 840 aagctggtga ctgatttgac taaagtacat acagaatgtt gccatggcga ccttttagaa 900 tgtgctgatg acagagcaga tttggctaag tatatctgcg aaaatcaaga ttcaatcagc 960 tctaagctga aggaatgttg cgagaaacca ctgttagaaa aatcgcattg tattgctgaa 1020 gttgaaaatg atgagatgcc tgctgacttg ccttctcttg ccgctgattt tgttgagtcg 1080 aaggatgtct gtaagaatta tgctgaagct aaagacgttt tcctgggtat gttcttatat 1140 gagtacgcaa gacgtcaccc agattactct gtggttctgc tactgagatt ggctaaaaca 1200 tacgagacaa cgctggagaa gtgctgtgct gccgctgacc ctcatgagtg ctatgcaaag 1260 gtttttgatg aattcaaacc attggttgaa gagcctcaaa acttgataaa gcagaactgt 1320 gagctgtttg agcaattggg tgagtataag ttccaaaatg ccctgttggt gagatataca 1380 aaaaaggtac cccaagtttc aacgcccact ttagttgaag tgtccagaaa tcttggtaaa 1440 gtgggtagca aatgttgcaa gcatccagaa gccaagcgaa tgccctgtgc tgaggattat 1500 ctgtccgtcg tgttgaacca attgtgcgta ttacacgaaa aaaccccagt ctctgataga 1560 gtcaccaaat gttgcactga gtcactagtt aatagaaggc cttgtttttc cgctttggaa 1620 gttgatgaaa cctacgtgcc taaggaattt aacgctgaga cctttacctt tcacgctgac 1680 atttgtactt tgagtgaaaa agagcgtcaa atcaaaaagc aaaccgctct tgttgaattg 1740 gtgaaacaca agcctaaggc tacgaaggag cagcttaaag ccgtcatgga cgatttcgcc 1800 gcatttgttg aaaaatgctg taaagctgat gacaaggaaa catgtttcgc tgaagaggga 1860 aagaaattgg ttgcggccag tcaggccgca cttggtttgg gaggaagcgg aggatctggc 1920 ggttccggag gctcttgcgc caaccccctg ggcctgaaga acaacagcat ccccgacaag 1980 cagatcaccg cctccagcag ctacaagacc tggggcctgc acctgttcag ctggaacccc 2040 agctacgccc ggctggacaa gcagggcaac ttcaacgcct gggtggccgg cagctacggc 2100 aacgaccagt ggctgcaggt ggacctgggc agcagcaaag aagtgaccgg catcatcacc 2160 cagggggcca gaaacttcgg cagcgtgcag ttcgtggcca gctacaaagt ggcctactcc 2220 aacgacagcg ccaactggac cgagtaccag gacccccgga ccggcagctc caagatcttc 2280 cccggcaact gggacaacca cagccacaag aagaatctgt tcgaaacccc catcctggcc 2340 agatacgtgc ggatcctgcc cgtggcctgg cacaaccgga tcgccctgag actggaactg 2400 ctgggatgtg gctctcacca ccaccatcac cat 2433 <210> 38 <211> 971 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 38 Leu Asp Ile Cys Ser Lys Asn Pro Cys His Asn Gly Gly Leu Cys Glu 1 5 10 15 Glu Ile Ser Gln Glu Val Arg Gly Glu Val Phe Pro Ser Tyr Thr Cys 20 25 30 Thr Cys Leu Lys Gly Tyr Ala Gly Asn His Cys Glu Thr Lys Gly Ser 35 40 45 Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 50 55 60 Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 65 70 75 80 Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 85 90 95 Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 100 105 110 Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 115 120 125 Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 130 135 140 Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 145 150 155 160 Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 165 170 175 Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 180 185 190 Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 195 200 205 Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 210 215 220 Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 225 230 235 240 Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 245 250 255 Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 260 265 270 Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 275 280 285 Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 290 295 300 Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 305 310 315 320 Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 325 330 335 Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 340 345 350 Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 355 360 365 Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 370 375 380 Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 385 390 395 400 Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 405 410 415 Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 420 425 430 Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 435 440 445 Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 450 455 460 Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 465 470 475 480 Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 485 490 495 Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 500 505 510 Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 515 520 525 Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 530 535 540 Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 545 550 555 560 Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 565 570 575 Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 580 585 590 Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 595 600 605 Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 610 615 620 Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Ser Gly Gly Ser Gly 625 630 635 640 Gly Ser Gly Gly Ser Cys Val Glu Pro Leu Gly Met Glu Asn Gly Asn 645 650 655 Ile Ala Asn Ser Gln Ile Ala Ala Ser Ser Val Arg Val Thr Phe Leu 660 665 670 Gly Leu Gln His Trp Val Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly 675 680 685 Met Val Asn Ala Trp Thr Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile 690 695 700 Gln Val Asn Leu Leu Arg Arg Met Trp Val Thr Gly Val Val Thr Gln 705 710 715 720 Gly Ala Ser Arg Leu Ala Ser His Glu Tyr Leu Lys Ala Phe Lys Val 725 730 735 Ala Tyr Ser Leu Asn Gly His Glu Phe Asp Phe Ile His Asp Val Asn 740 745 750 Lys Lys His Lys Glu Phe Val Gly Asn Trp Asn Lys Asn Ala Val His 755 760 765 Val Asn Leu Phe Glu Thr Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr 770 775 780 Pro Thr Ser Cys His Thr Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly 785 790 795 800 Cys Glu Leu Asn Gly Cys Ala Asn Pro Leu Gly Leu Lys Asn Asn Ser 805 810 815 Ile Pro Asp Lys Gln Ile Thr Ala Ser Ser Ser Tyr Lys Thr Trp Gly 820 825 830 Leu His Leu Phe Ser Trp Asn Pro Ser Tyr Ala Arg Leu Asp Lys Gln 835 840 845 Gly Asn Phe Asn Ala Trp Val Ala Gly Ser Tyr Gly Asn Asp Gln Trp 850 855 860 Leu Gln Val Asp Leu Gly Ser Ser Lys Glu Val Thr Gly Ile Ile Thr 865 870 875 880 Gln Gly Ala Arg Asn Phe Gly Ser Val Gln Phe Val Ala Ser Tyr Lys 885 890 895 Val Ala Tyr Ser Asn Asp Ser Ala Asn Trp Thr Glu Tyr Gln Asp Pro 900 905 910 Arg Thr Gly Ser Ser Lys Ile Phe Pro Gly Asn Trp Asp Asn His Ser 915 920 925 His Lys Lys Asn Leu Phe Glu Thr Pro Ile Leu Ala Arg Tyr Val Arg 930 935 940 Ile Leu Pro Val Ala Trp His Asn Arg Ile Ala Leu Arg Leu Glu Leu 945 950 955 960 Leu Gly Cys Gly Ser His His His His His His 965 970 <210> 39 <211> 2913 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 39 ctggacatct gcagcaagaa tccttgccac aacggcggcc tgtgcgaaga gatttctcaa 60 gaagtgcggg gcgaggtttt ccccagctac acctgtacat gtctgaaggg ctacgccggc 120 aaccactgcg agacaaaagg atccgatgct cacaagagcg aggtggccca cagattcaag 180 gatctgggcg aagagaactt caaggccctg gtgctgatcg ccttcgctca gtatctccag 240 cagagccctt tcgaggacca cgtgaagctg gtcaacgaag tgaccgagtt cgccaagacc 300 tgtgtggccg atgagagcgc cgagaactgt gataagagcc tgcacaccct gttcggcgac 360 aagctgtgta cagtggccac actgagagaa acctacggcg agatggccga ctgctgtgcc 420 aagcaagagc ccgagagaaa cgagtgcttc ctgcagcaca aggacgacaa ccccaacctg 480 cctagactcg tgcgacccga agtggatgtg atgtgcaccg cctttcacga caacgaggaa 540 accttcctga agaagtacct gtacgagatc gccagacggc acccctactt ttatgcccct 600 gagctgctgt tcttcgccaa gcggtataag gccgccttca ccgaatgttg ccaggccgct 660 gataaggctg cctgtctgct gcctaagctg gacgagctga gagatgaggg caaagccagc 720 tctgccaagc agagactgaa gtgcgccagc ctgcagaagt tcggcgagag agcttttaag 780 gcctgggccg ttgccagact gagccagaga tttcctaagg ccgagtttgc cgaggtgtcc 840 aagctcgtga ccgatctgac aaaggtgcac accgagtgct gtcacggcga tctgctggaa 900 tgtgccgacg atagagccga cctggccaag tacatctgcg agaaccagga cagcatcagc 960 agcaagctga aagagtgctg cgagaagccc ctgctggaaa agtctcactg tatcgccgag 1020 gtggaaaacg acgagatgcc tgccgatctg cctagcctgg ctgccgattt cgtggaaagc 1080 aaggacgtgt gcaagaacta cgccgaggcc aaggatgtgt ttctgggcat gtttctgtat 1140 gagtacgccc gcagacaccc cgactattct gtggttctgc tgctgcggct ggccaaaacc 1200 tacgagacaa ccctggaaaa atgctgcgcc gctgccgatc ctcacgagtg ttatgccaag 1260 gtgttcgacg agttcaagcc tctggtggaa gaaccccaga acctgatcaa gcagaactgc 1320 gagctgttcg agcagctggg cgagtacaag ttccagaatg ccctgctcgt gcggtacacc 1380 aagaaagtgc ctcaggtgtc cacacctaca ctggttgagg tgtcccggaa tctgggcaaa 1440 gtgggcagca agtgttgcaa gcaccctgag gccaagagaa tgccttgcgc cgaggattac 1500 ctgagcgtgg tgctgaatca gctgtgcgtg ctgcacgaga aaacccctgt gtccgacaga 1560 gtgaccaagt gctgtaccga gagcctcgtg aacagaaggc cttgctttag cgccctggaa 1620 gtggacgaga catacgtgcc caaagagttc aacgccgaga cattcacctt ccacgccgac 1680 atctgtaccc tgagcgagaa agagcggcag atcaagaagc agacagccct ggtcgagctg 1740 gttaagcaca agcccaaggc caccaaagaa cagctgaagg ccgtgatgga cgacttcgcc 1800 gcctttgtcg agaagtgctg caaggccgac gacaaagaga catgcttcgc cgaagagggc 1860 aagaaactgg tggctgcctc tcaggctgct ctcggacttg gaggaagcgg aggatctggc 1920 ggttccggag gctcttgtgt ggaacccctc ggcatggaaa acggcaatat cgccaatagc 1980 cagattgccg ccagcagcgt cagagtgaca tttctgggac tgcagcactg ggtgcccgag 2040 ctggctagac tgaatagagc cggcatggtc aacgcctgga cacccagcag caacgacgat 2100 aacccttgga ttcaagtgaa cctgctgcgg cgtatgtggg tcacaggtgt tgttacacag 2160 ggcgcctcta gactggccag ccacgagtat ctgaaggcct ttaaggtggc ctacagcctg 2220 aacggccacg agttcgactt catccacgac gtgaacaaga agcacaaaga gtttgtcggc 2280 aactggaaca agaacgccgt gcacgtgaac ctgttcgaga cacctgtgga agcccagtac 2340 gtgcggctgt accctacaag ctgtcacacc gcctgcactc tgagattcga actgctggga 2400 tgcgagctga acggctgtgc taatcctctg ggcctgaaga acaacagcat ccccgataag 2460 cagatcaccg ccagctccag ctataagaca tggggcctgc acctgttcag ctggaaccct 2520 tcttacgcca gactggacaa gcagggcaac ttcaatgctt gggtggccgg cagctacggc 2580 aatgatcagt ggctgcaagt ggacctgggc agcagcaaag aagtgacagg catcatcacc 2640 cagggcgcca gaaatttcgg cagcgtgcag tttgtggcca gctacaaagt ggcctactcc 2700 aacgacagcg ccaactggac cgagtatcag gaccctagaa ccggcagctc caagatcttc 2760 cccggcaatt gggacaacca cagccacaag aagaatctgt tcgaaacccc tatcctggcc 2820 agatatgtgc gcattctgcc cgtggcctgg cacaacagaa ttgccctgag actggaactg 2880 ctcggctgtg gctctcacca ccaccatcac cat 2913 <210> 40 <211> 592 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 40 Leu Asp Ile Cys Ser Lys Asn Pro Cys His Asn Gly Gly Leu Cys Glu 1 5 10 15 Glu Ile Ser Gln Glu Val Arg Gly Asp Val Phe Pro Ser Tyr Thr Cys 20 25 30 Thr Cys Leu Lys Gly Tyr Ala Gly Asn His Cys Glu Thr Lys Gly Ser 35 40 45 Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe 50 55 60 Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr 65 70 75 80 Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser 85 90 95 Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala 100 105 110 Lys Arg Met Pro Cys Ala Glu Asp Cys Leu Ser Val Phe Leu Asn Gln 115 120 125 Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys 130 135 140 Cys Cys Thr Glu Ser Leu Val Asn Gly Arg Pro Cys Phe Ser Ala Leu 145 150 155 160 Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe 165 170 175 Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile 180 185 190 Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala 195 200 205 Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val 210 215 220 Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu 225 230 235 240 Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly 245 250 255 Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Cys Val Glu Pro Leu Gly 260 265 270 Met Glu Asn Gly Asn Ile Ala Asn Ser Gln Ile Ala Ala Ser Ser Val 275 280 285 Arg Val Thr Phe Leu Gly Leu Gln His Trp Val Pro Glu Leu Ala Arg 290 295 300 Leu Asn Arg Ala Gly Met Val Asn Ala Trp Thr Pro Ser Ser Asn Asp 305 310 315 320 Asp Asn Pro Trp Ile Gln Val Asn Leu Leu Arg Arg Met Trp Val Thr 325 330 335 Gly Val Val Thr Gln Gly Ala Ser Arg Leu Ala Ser His Glu Tyr Leu 340 345 350 Lys Ala Phe Lys Val Ala Tyr Ser Leu Asn Gly His Glu Phe Asp Phe 355 360 365 Ile His Asp Val Asn Lys Lys His Lys Glu Phe Val Gly Asn Trp Asn 370 375 380 Lys Asn Ala Val His Val Asn Leu Phe Glu Thr Pro Val Glu Ala Gln 385 390 395 400 Tyr Val Arg Leu Tyr Pro Thr Ser Cys His Thr Ala Cys Thr Leu Arg 405 410 415 Phe Glu Leu Leu Gly Cys Glu Leu Asn Gly Cys Ala Asn Pro Leu Gly 420 425 430 Leu Lys Asn Asn Ser Ile Pro Asp Lys Gln Ile Thr Ala Ser Ser Ser 435 440 445 Tyr Lys Thr Trp Gly Leu His Leu Phe Ser Trp Asn Pro Ser Tyr Ala 450 455 460 Arg Leu Asp Lys Gln Gly Asn Phe Asn Ala Trp Val Ala Gly Ser Tyr 465 470 475 480 Gly Asn Asp Gln Trp Leu Gln Val Asp Leu Gly Ser Ser Lys Glu Val 485 490 495 Thr Gly Ile Ile Thr Gln Gly Ala Arg Asn Phe Gly Ser Val Gln Phe 500 505 510 Val Ala Ser Tyr Lys Val Ala Tyr Ser Asn Asp Ser Ala Asn Trp Thr 515 520 525 Glu Tyr Gln Asp Pro Arg Thr Gly Ser Ser Lys Ile Phe Pro Gly Asn 530 535 540 Trp Asp Asn His Ser His Lys Lys Asn Leu Phe Glu Thr Pro Ile Leu 545 550 555 560 Ala Arg Tyr Val Arg Ile Leu Pro Val Ala Trp His Asn Arg Ile Ala 565 570 575 Leu Arg Leu Glu Leu Leu Gly Cys Gly Ser His His His His His His 580 585 590 <210> 41 <211> 1776 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 41 ctggacatct gcagcaagaa tccttgccac aacggcggcc tgtgcgaaga gatttctcaa 60 gaagtgcggg gcgacgtttt ccccagctac acctgtacat gtctgaaggg ctacgccggc 120 aaccactgcg agacaaaagg atccctggtg gaagaacccc agaacctgat caagcagaac 180 tgcgagctgt tcgagcagct gggcgagtac aagttccaga atgccctgct cgtgcggtac 240 accaagaaag tgcctcaggt gtccacacct acactggtcg aggtgtccag aaacctgggc 300 aaagtgggca gcaagtgctg caagcaccct gaggccaaaa gaatgccttg cgccgaggat 360 tgcctgagcg tgttcctgaa tcagctgtgc gtgctgcacg agaaaacccc tgtgtccgac 420 agagtgacca agtgctgtac cgagagcctg gtcaacggca gaccttgctt tagcgccctg 480 gaagtggatg agacatacgt gcccaaagag ttcaacgccg agacattcac cttccacgcc 540 gacatctgta ccctgagcga gaaagagcgg cagatcaaga agcagacagc cctggtcgag 600 ctggtcaagc acaagcctaa ggccaccaaa gaacagctga aggccgtgat ggacgacttc 660 gccgccttcg tggaaaagtg ttgcaaggcc gacgacaaag agacatgctt cgccgaagag 720 ggcaagaaac tggtggctgc ctctcaggct gctctcggac ttggaggaag cggaggatct 780 ggcggttccg gaggctcttg tgtggaaccc ctcggcatgg aaaacggcaa tatcgccaat 840 agccagatcg ccgccagcag cgtcagagtg acatttctgg gactgcagca ctgggtgcca 900 gagctggcta gactgaatag agccggcatg gtcaacgcct ggacacccag cagcaacgac 960 gacaacccct ggattcaagt gaacctgctg cggcgtatgt gggtcacagg tgttgttaca 1020 cagggcgcct ctagactggc cagccacgag tatctgaagg cctttaaggt ggcctacagc 1080 ctgaacggcc acgagttcga cttcatccac gacgtgaaca agaagcacaa agagtttgtc 1140 ggcaactgga acaagaacgc cgtgcacgtg aacctgttcg agacacctgt ggaagcccag 1200 tacgtgcggc tgtaccctac aagctgtcac accgcctgca cactgagatt cgaactgctg 1260 ggatgcgagc tgaacggctg tgctaatcct ctgggcctga agaacaacag catccccgat 1320 aagcagatca ccgcctccag cagctataag acatggggcc tgcacctgtt cagctggaac 1380 cctagctacg ccagactgga caagcagggc aactttaatg cctgggtggc cggcagctac 1440 ggcaatgatc aatggctgca agtggacctg ggcagcagca aagaagtgac cggcatcatt 1500 acccagggcg caagaaattt cggcagcgtg cagttcgtgg ccagctacaa agtggcctac 1560 tccaacgaca gcgccaactg gaccgagtat caggacccta gaaccggcag ctccaagatc 1620 ttccccggca attgggacaa ccacagccac aagaagaatc tgttcgaaac ccctatcctg 1680 gccagatatg tgcgcattct gcccgtggcc tggcacaaca gaattgccct gagactggaa 1740 ctgctcggct gtggctctca ccaccaccat caccat 1776 <210> 42 <211> 963 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 42 Leu Asp Ile Cys Ser Lys Asn Pro Cys His Asn Gly Gly Leu Cys Glu 1 5 10 15 Glu Ile Ser Gln Glu Val Arg Gly Asp Val Phe Pro Ser Tyr Thr Cys 20 25 30 Thr Cys Leu Lys Gly Tyr Ala Gly Asn His Cys Glu Thr Lys Gly Ser 35 40 45 Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 50 55 60 Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 65 70 75 80 Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 85 90 95 Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 100 105 110 Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 115 120 125 Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 130 135 140 Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 145 150 155 160 Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 165 170 175 Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 180 185 190 Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 195 200 205 Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 210 215 220 Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 225 230 235 240 Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 245 250 255 Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 260 265 270 Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 275 280 285 Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 290 295 300 Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 305 310 315 320 Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 325 330 335 Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 340 345 350 Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 355 360 365 Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 370 375 380 Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 385 390 395 400 Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 405 410 415 Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 420 425 430 Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 435 440 445 Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 450 455 460 Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 465 470 475 480 Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 485 490 495 Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 500 505 510 Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 515 520 525 Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 530 535 540 Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 545 550 555 560 Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 565 570 575 Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 580 585 590 Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 595 600 605 Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 610 615 620 Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Ser Gly Gly Ser Gly 625 630 635 640 Gly Ser Gly Gly Ser Cys Val Glu Pro Leu Gly Met Glu Asn Gly Asn 645 650 655 Ile Ala Asn Ser Gln Ile Ala Ala Ser Ser Val Arg Val Thr Phe Leu 660 665 670 Gly Leu Gln His Trp Val Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly 675 680 685 Met Val Asn Ala Trp Thr Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile 690 695 700 Gln Val Asn Leu Leu Arg Arg Met Trp Val Thr Gly Val Val Thr Gln 705 710 715 720 Gly Ala Ser Arg Leu Ala Ser His Glu Tyr Leu Lys Ala Phe Lys Val 725 730 735 Ala Tyr Ser Leu Asn Gly His Glu Phe Asp Phe Ile His Asp Val Asn 740 745 750 Lys Lys His Lys Glu Phe Val Gly Asn Trp Asn Lys Asn Ala Val His 755 760 765 Val Asn Leu Phe Glu Thr Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr 770 775 780 Pro Thr Ser Cys His Thr Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly 785 790 795 800 Cys Glu Leu Asn Gly Cys Ala Asn Pro Leu Gly Leu Lys Asn Asn Ser 805 810 815 Ile Pro Asp Lys Gln Ile Thr Ala Ser Ser Ser Tyr Lys Thr Trp Gly 820 825 830 Leu His Leu Phe Ser Trp Asn Pro Ser Tyr Ala Arg Leu Asp Lys Gln 835 840 845 Gly Asn Phe Asn Ala Trp Val Ala Gly Ser Tyr Gly Asn Asp Gln Trp 850 855 860 Leu Gln Val Asp Leu Gly Ser Ser Lys Glu Val Thr Gly Ile Ile Thr 865 870 875 880 Gln Gly Ala Arg Asn Phe Gly Ser Val Gln Phe Val Ala Ser Tyr Lys 885 890 895 Val Ala Tyr Ser Asn Asp Ser Ala Asn Trp Thr Glu Tyr Gln Asp Pro 900 905 910 Arg Thr Gly Ser Ser Lys Ile Phe Pro Gly Asn Trp Asp Asn His Ser 915 920 925 His Lys Lys Asn Leu Phe Glu Thr Pro Ile Leu Ala Arg Tyr Val Arg 930 935 940 Ile Leu Pro Val Ala Trp His Asn Arg Ile Ala Leu Arg Leu Glu Leu 945 950 955 960 Leu Gly Cys <210> 43 <211> 2889 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 43 ctggacatct gcagcaagaa tccttgccac aacggcggcc tgtgcgaaga gatttctcaa 60 gaagtgcggg gcgacgtttt ccccagctac acctgtacat gtctgaaggg ctacgccggc 120 aaccactgcg agacaaaagg atccgatgct cacaagagcg aggtggccca cagattcaag 180 gatctgggcg aagagaactt caaggccctg gtgctgatcg ccttcgctca gtatctccag 240 cagagccctt tcgaggacca cgtgaagctg gtcaacgaag tgaccgagtt cgccaagacc 300 tgtgtggccg atgagagcgc cgagaactgt gataagagcc tgcacaccct gttcggcgac 360 aagctgtgta cagtggccac actgagagaa acctacggcg agatggccga ctgctgtgcc 420 aagcaagagc ccgagagaaa cgagtgcttc ctgcagcaca aggacgacaa ccccaacctg 480 cctagactcg tgcgacccga agtggatgtg atgtgcaccg cctttcacga caacgaggaa 540 accttcctga agaagtacct gtacgagatc gccagacggc acccctactt ttatgcccct 600 gagctgctgt tcttcgccaa gcggtataag gccgccttca ccgaatgttg ccaggccgct 660 gataaggctg cctgtctgct gcctaagctg gacgagctga gagatgaggg caaagccagc 720 tctgccaagc agagactgaa gtgcgccagc ctgcagaagt tcggcgagag agcttttaag 780 gcctgggccg ttgccagact gagccagaga tttcctaagg ccgagtttgc cgaggtgtcc 840 aagctcgtga ccgatctgac aaaggtgcac accgagtgct gtcacggcga tctgctggaa 900 tgtgccgacg atagagccga cctggccaag tacatctgcg agaaccagga cagcatcagc 960 agcaagctga aagagtgctg cgagaagccc ctgctggaaa agtctcactg tatcgccgag 1020 gtggaaaacg acgagatgcc tgccgatctg cctagcctgg ctgccgattt cgtggaaagc 1080 aaggacgtgt gcaagaacta cgccgaggcc aaggatgtgt ttctgggcat gtttctgtat 1140 gagtacgccc gcagacaccc cgactattct gtggttctgc tgctgcggct ggccaaaacc 1200 tacgagacaa ccctggaaaa atgctgcgcc gctgccgatc ctcacgagtg ttatgccaag 1260 gtgttcgacg agttcaagcc tctggtggaa gaaccccaga acctgatcaa gcagaactgc 1320 gagctgttcg agcagctggg cgagtacaag ttccagaatg ccctgctcgt gcggtacacc 1380 aagaaagtgc ctcaggtgtc cacacctaca ctggttgagg tgtcccggaa tctgggcaaa 1440 gtgggcagca agtgttgcaa gcaccctgag gccaagagaa tgccttgcgc cgaggattac 1500 ctgagcgtgg tgctgaatca gctgtgcgtg ctgcacgaga aaacccctgt gtccgacaga 1560 gtgaccaagt gctgtaccga gagcctcgtg aacagaaggc cttgctttag cgccctggaa 1620 gtggacgaga catacgtgcc caaagagttc aacgccgaga cattcacctt ccacgccgac 1680 atctgtaccc tgagcgagaa agagcggcag atcaagaagc agacagccct ggtcgagctg 1740 gttaagcaca agcccaaggc caccaaagaa cagctgaagg ccgtgatgga cgacttcgcc 1800 gcctttgtcg agaagtgctg caaggccgac gacaaagaga catgcttcgc cgaagagggc 1860 aagaaactgg tggctgcctc tcaggctgct ctcggacttg gaggaagcgg aggatctggc 1920 ggttccggag gctcttgtgt ggaacccctc ggcatggaaa acggcaatat cgccaatagc 1980 cagattgccg ccagcagcgt cagagtgaca tttctgggac tgcagcactg ggtgcccgag 2040 ctggctagac tgaatagagc cggcatggtc aacgcctgga cacccagcag caacgacgat 2100 aacccttgga ttcaagtgaa cctgctgcgg cgtatgtggg tcacaggtgt tgttacacag 2160 ggcgcctcta gactggccag ccacgagtat ctgaaggcct ttaaggtggc ctacagcctg 2220 aacggccacg agttcgactt catccacgac gtgaacaaga agcacaaaga gtttgtcggc 2280 aactggaaca agaacgccgt gcacgtgaac ctgttcgaga cacctgtgga agcccagtac 2340 gtgcggctgt accctacaag ctgtcacacc gcctgcactc tgagattcga actgctggga 2400 tgcgagctga acggctgtgc taatcctctg ggcctgaaga acaacagcat ccccgataag 2460 cagatcaccg ccagctccag ctataagaca tggggcctgc acctgttcag ctggaaccct 2520 tcttacgcca gactggacaa gcagggcaac ttcaatgctt gggtggccgg cagctacggc 2580 aatgatcagt ggctgcaagt ggacctgggc agcagcaaag aagtgacagg catcatcacc 2640 cagggcgcca gaaatttcgg cagcgtgcag tttgtggcca gctacaaagt ggcctactcc 2700 aacgacagcg ccaactggac cgagtatcag gaccctagaa ccggcagctc caagatcttc 2760 cccggcaatt gggacaacca cagccacaag aagaatctgt tcgaaacccc tatcctggcc 2820 agatatgtgc gcattctgcc cgtggcctgg cacaacagaa ttgccctgag actggaactg 2880 ctcggctgt 2889 <210> 44 <211> 971 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 44 Leu Asp Ile Cys Ser Lys Asn Pro Cys His Asn Gly Gly Leu Cys Glu 1 5 10 15 Glu Ile Ser Gln Glu Val Arg Gly Asp Val Phe Pro Ser Tyr Thr Cys 20 25 30 Thr Cys Leu Lys Gly Tyr Ala Gly Asn His Cys Glu Thr Lys Gly Ser 35 40 45 Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 50 55 60 Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 65 70 75 80 Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 85 90 95 Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 100 105 110 Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 115 120 125 Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 130 135 140 Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 145 150 155 160 Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 165 170 175 Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 180 185 190 Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 195 200 205 Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 210 215 220 Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 225 230 235 240 Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 245 250 255 Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 260 265 270 Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 275 280 285 Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 290 295 300 Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 305 310 315 320 Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 325 330 335 Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 340 345 350 Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 355 360 365 Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 370 375 380 Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 385 390 395 400 Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 405 410 415 Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 420 425 430 Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 435 440 445 Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 450 455 460 Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 465 470 475 480 Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 485 490 495 Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 500 505 510 Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 515 520 525 Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 530 535 540 Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 545 550 555 560 Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 565 570 575 Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 580 585 590 Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 595 600 605 Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 610 615 620 Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Ser Gly Gly Ser Gly 625 630 635 640 Gly Ser Gly Gly Ser Cys Val Glu Pro Leu Gly Met Glu Asn Gly Asn 645 650 655 Ile Ala Asn Ser Gln Ile Ala Ala Ser Ser Val Arg Val Thr Phe Leu 660 665 670 Gly Leu Gln His Trp Val Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly 675 680 685 Met Val Asn Ala Trp Thr Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile 690 695 700 Gln Val Asn Leu Leu Arg Arg Met Trp Val Thr Gly Val Val Thr Gln 705 710 715 720 Gly Ala Ser Arg Leu Ala Ser His Glu Tyr Leu Lys Ala Phe Lys Val 725 730 735 Ala Tyr Ser Leu Asn Gly His Glu Phe Asp Phe Ile His Asp Val Asn 740 745 750 Lys Lys His Lys Glu Phe Val Gly Asn Trp Asn Lys Asn Ala Val His 755 760 765 Val Asn Leu Phe Glu Thr Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr 770 775 780 Pro Thr Ser Cys His Thr Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly 785 790 795 800 Cys Glu Leu Asn Gly Cys Ala Asn Pro Leu Gly Leu Lys Asn Asn Ser 805 810 815 Ile Pro Asp Lys Gln Ile Thr Ala Ser Ser Ser Tyr Lys Thr Trp Gly 820 825 830 Leu His Leu Phe Ser Trp Asn Pro Ser Tyr Ala Arg Leu Asp Lys Gln 835 840 845 Gly Asn Phe Asn Ala Trp Val Ala Gly Ser Tyr Gly Asn Asp Gln Trp 850 855 860 Leu Gln Val Asp Leu Gly Ser Ser Lys Glu Val Thr Gly Ile Ile Thr 865 870 875 880 Gln Gly Ala Arg Asn Phe Gly Ser Val Gln Phe Val Ala Ser Tyr Lys 885 890 895 Val Ala Tyr Ser Asn Asp Ser Ala Asn Trp Thr Glu Tyr Gln Asp Pro 900 905 910 Arg Thr Gly Ser Ser Lys Ile Phe Pro Gly Asn Trp Asp Asn His Ser 915 920 925 His Lys Lys Asn Leu Phe Glu Thr Pro Ile Leu Ala Arg Tyr Val Arg 930 935 940 Ile Leu Pro Val Ala Trp His Asn Arg Ile Ala Leu Arg Leu Glu Leu 945 950 955 960 Leu Gly Cys Gly Ser His His His His His His 965 970 <210> 45 <211> 2913 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 45 ctggacatct gcagcaagaa tccttgccac aacggcggcc tgtgcgaaga gatttctcaa 60 gaagtgcggg gcgacgtttt ccccagctac acctgtacat gtctgaaggg ctacgccggc 120 aaccactgcg agacaaaagg atccgatgct cacaagagcg aggtggccca cagattcaag 180 gatctgggcg aagagaactt caaggccctg gtgctgatcg ccttcgctca gtatctccag 240 cagagccctt tcgaggacca cgtgaagctg gtcaacgaag tgaccgagtt cgccaagacc 300 tgtgtggccg atgagagcgc cgagaactgt gataagagcc tgcacaccct gttcggcgac 360 aagctgtgta cagtggccac actgagagaa acctacggcg agatggccga ctgctgtgcc 420 aagcaagagc ccgagagaaa cgagtgcttc ctgcagcaca aggacgacaa ccccaacctg 480 cctagactcg tgcgacccga agtggatgtg atgtgcaccg cctttcacga caacgaggaa 540 accttcctga agaagtacct gtacgagatc gccagacggc acccctactt ttatgcccct 600 gagctgctgt tcttcgccaa gcggtataag gccgccttca ccgaatgttg ccaggccgct 660 gataaggctg cctgtctgct gcctaagctg gacgagctga gagatgaggg caaagccagc 720 tctgccaagc agagactgaa gtgcgccagc ctgcagaagt tcggcgagag agcttttaag 780 gcctgggccg ttgccagact gagccagaga tttcctaagg ccgagtttgc cgaggtgtcc 840 aagctcgtga ccgatctgac aaaggtgcac accgagtgct gtcacggcga tctgctggaa 900 tgtgccgacg atagagccga cctggccaag tacatctgcg agaaccagga cagcatcagc 960 agcaagctga aagagtgctg cgagaagccc ctgctggaaa agtctcactg tatcgccgag 1020 gtggaaaacg acgagatgcc tgccgatctg cctagcctgg ctgccgattt cgtggaaagc 1080 aaggacgtgt gcaagaacta cgccgaggcc aaggatgtgt ttctgggcat gtttctgtat 1140 gagtacgccc gcagacaccc cgactattct gtggttctgc tgctgcggct ggccaaaacc 1200 tacgagacaa ccctggaaaa atgctgcgcc gctgccgatc ctcacgagtg ttatgccaag 1260 gtgttcgacg agttcaagcc tctggtggaa gaaccccaga acctgatcaa gcagaactgc 1320 gagctgttcg agcagctggg cgagtacaag ttccagaatg ccctgctcgt gcggtacacc 1380 aagaaagtgc ctcaggtgtc cacacctaca ctggttgagg tgtcccggaa tctgggcaaa 1440 gtgggcagca agtgttgcaa gcaccctgag gccaagagaa tgccttgcgc cgaggattac 1500 ctgagcgtgg tgctgaatca gctgtgcgtg ctgcacgaga aaacccctgt gtccgacaga 1560 gtgaccaagt gctgtaccga gagcctcgtg aacagaaggc cttgctttag cgccctggaa 1620 gtggacgaga catacgtgcc caaagagttc aacgccgaga cattcacctt ccacgccgac 1680 atctgtaccc tgagcgagaa agagcggcag atcaagaagc agacagccct ggtcgagctg 1740 gttaagcaca agcccaaggc caccaaagaa cagctgaagg ccgtgatgga cgacttcgcc 1800 gcctttgtcg agaagtgctg caaggccgac gacaaagaga catgcttcgc cgaagagggc 1860 aagaaactgg tggctgcctc tcaggctgct ctcggacttg gaggaagcgg aggatctggc 1920 ggttccggag gctcttgtgt ggaacccctc ggcatggaaa acggcaatat cgccaatagc 1980 cagattgccg ccagcagcgt cagagtgaca tttctgggac tgcagcactg ggtgcccgag 2040 ctggctagac tgaatagagc cggcatggtc aacgcctgga cacccagcag caacgacgat 2100 aacccttgga ttcaagtgaa cctgctgcgg cgtatgtggg tcacaggtgt tgttacacag 2160 ggcgcctcta gactggccag ccacgagtat ctgaaggcct ttaaggtggc ctacagcctg 2220 aacggccacg agttcgactt catccacgac gtgaacaaga agcacaaaga gtttgtcggc 2280 aactggaaca agaacgccgt gcacgtgaac ctgttcgaga cacctgtgga agcccagtac 2340 gtgcggctgt accctacaag ctgtcacacc gcctgcactc tgagattcga actgctggga 2400 tgcgagctga acggctgtgc taatcctctg ggcctgaaga acaacagcat ccccgataag 2460 cagatcaccg ccagctccag ctataagaca tggggcctgc acctgttcag ctggaaccct 2520 tcttacgcca gactggacaa gcagggcaac ttcaatgctt gggtggccgg cagctacggc 2580 aatgatcagt ggctgcaagt ggacctgggc agcagcaaag aagtgacagg catcatcacc 2640 cagggcgcca gaaatttcgg cagcgtgcag tttgtggcca gctacaaagt ggcctactcc 2700 aacgacagcg ccaactggac cgagtatcag gaccctagaa ccggcagctc caagatcttc 2760 cccggcaatt gggacaacca cagccacaag aagaatctgt tcgaaacccc tatcctggcc 2820 agatatgtgc gcattctgcc cgtggcctgg cacaacagaa ttgccctgag actggaactg 2880 ctcggctgtg gctctcacca ccaccatcac cat 2913 <210> 46 <211> 947 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 46 Leu Asp Ile Cys Ser Lys Asn Pro Cys His Asn Gly Gly Leu Cys Glu 1 5 10 15 Glu Ile Ser Gln Glu Val Arg Gly Asp Val Phe Pro Ser Tyr Thr Cys 20 25 30 Thr Cys Leu Lys Gly Tyr Ala Gly Asn His Cys Glu Thr Lys Asp Ala 35 40 45 His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn 50 55 60 Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Ser 65 70 75 80 Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala 85 90 95 Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu 100 105 110 His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu 115 120 125 Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg 130 135 140 Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg 145 150 155 160 Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn 165 170 175 Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His 180 185 190 Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys 195 200 205 Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu 210 215 220 Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala 225 230 235 240 Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala 245 250 255 Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala 260 265 270 Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His 275 280 285 Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala 290 295 300 Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys 305 310 315 320 Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile 325 330 335 Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala 340 345 350 Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala 355 360 365 Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His 370 375 380 Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu 385 390 395 400 Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr 405 410 415 Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn 420 425 430 Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys 435 440 445 Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val 450 455 460 Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly 465 470 475 480 Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu 485 490 495 Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys 500 505 510 Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val 515 520 525 Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val 530 535 540 Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys 545 550 555 560 Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val 565 570 575 Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala 580 585 590 Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp 595 600 605 Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala 610 615 620 Ser Gln Ala Ala Leu Cys Val Glu Pro Leu Gly Met Glu Asn Gly Asn 625 630 635 640 Ile Ala Asn Ser Gln Ile Ala Ala Ser Ser Val Arg Val Thr Phe Leu 645 650 655 Gly Leu Gln His Trp Val Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly 660 665 670 Met Val Asn Ala Trp Thr Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile 675 680 685 Gln Val Asn Leu Leu Arg Arg Met Trp Val Thr Gly Val Val Thr Gln 690 695 700 Gly Ala Ser Arg Leu Ala Ser His Glu Tyr Leu Lys Ala Phe Lys Val 705 710 715 720 Ala Tyr Ser Leu Asn Gly His Glu Phe Asp Phe Ile His Asp Val Asn 725 730 735 Lys Lys His Lys Glu Phe Val Gly Asn Trp Asn Lys Asn Ala Val His 740 745 750 Val Asn Leu Phe Glu Thr Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr 755 760 765 Pro Thr Ser Cys His Thr Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly 770 775 780 Cys Glu Leu Asn Gly Cys Ala Asn Pro Leu Gly Leu Lys Asn Asn Ser 785 790 795 800 Ile Pro Asp Lys Gln Ile Thr Ala Ser Ser Ser Tyr Lys Thr Trp Gly 805 810 815 Leu His Leu Phe Ser Trp Asn Pro Ser Tyr Ala Arg Leu Asp Lys Gln 820 825 830 Gly Asn Phe Asn Ala Trp Val Ala Gly Ser Tyr Gly Asn Asp Gln Trp 835 840 845 Leu Gln Val Asp Leu Gly Ser Ser Lys Glu Val Thr Gly Ile Ile Thr 850 855 860 Gln Gly Ala Arg Asn Phe Gly Ser Val Gln Phe Val Ala Ser Tyr Lys 865 870 875 880 Val Ala Tyr Ser Asn Asp Ser Ala Asn Trp Thr Glu Tyr Gln Asp Pro 885 890 895 Arg Thr Gly Ser Ser Lys Ile Phe Pro Gly Asn Trp Asp Asn His Ser 900 905 910 His Lys Lys Asn Leu Phe Glu Thr Pro Ile Leu Ala Arg Tyr Val Arg 915 920 925 Ile Leu Pro Val Ala Trp His Asn Arg Ile Ala Leu Arg Leu Glu Leu 930 935 940 Leu Gly Cys 945 <210> 47 <211> 2841 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 47 ctggacatct gtagcaagaa cccttgccac aacggcggcc tgtgcgaaga gatttctcaa 60 gaagtgcggg gcgacgtttt ccccagctac acctgtacat gtctgaaggg ctacgccggc 120 aaccactgcg agacaaagga tgcccacaag agcgaggtgg cccacagatt caaggatctg 180 ggcgaagaga acttcaaggc cctggtgctg atcgccttcg ctcagtatct ccagcagagc 240 cctttcgagg accacgtgaa gctggtcaac gaagtgaccg agttcgccaa gacctgtgtg 300 gccgatgaga gcgccgagaa ctgtgataag agcctgcaca ccctgttcgg cgacaagctg 360 tgtacagtgg ccacactgag agaaacctac ggcgagatgg ccgactgctg tgccaagcaa 420 gagcccgaga gaaacgagtg cttcctccag cacaaggacg acaaccccaa cctgcctaga 480 ctcgtgcgac ccgaagtgga tgtgatgtgc accgcctttc acgacaacga ggaaaccttc 540 ctgaagaagt acctgtacga gatcgccaga cggcacccct acttttatgc ccctgagctg 600 ctgttcttcg ccaagcggta taaggccgcc ttcaccgaat gttgccaggc cgctgataag 660 gctgcctgtc tgctgcctaa gctggacgag ctgagagatg agggcaaagc cagctctgcc 720 aagcagagac tgaaatgcgc cagcctccag aagttcggcg agagagcttt taaggcctgg 780 gccgttgcca gactgagcca gagatttcct aaggccgagt ttgccgaggt gtccaagctc 840 gtgaccgatc tgacaaaggt gcacaccgag tgctgtcacg gcgatctgct ggaatgtgcc 900 gacgatagag ccgacctggc caagtacatc tgcgagaacc aggacagcat cagcagcaag 960 ctgaaagagt gctgcgagaa gcccctgctg gaaaagtctc actgtatcgc cgaggtggaa 1020 aacgacgaga tgcctgccga tctgcctagc ctggctgccg atttcgtgga aagcaaggac 1080 gtgtgcaaga actacgccga ggccaaggat gtgtttctgg gcatgtttct gtatgagtac 1140 gcccgcagac accccgacta ttctgtggtt ctgctgctgc ggctggccaa aacctacgag 1200 acaaccctgg aaaaatgctg cgccgctgcc gatcctcacg agtgttatgc caaggtgttc 1260 gacgagttca agcctctggt ggaagaaccc cagaacctga tcaagcagaa ctgcgagctg 1320 ttcgagcagc tgggcgagta caagttccag aatgccctgc tcgtgcggta caccaagaaa 1380 gtgcctcagg tgtccacacc tacactggtt gaggtgtccc ggaatctggg caaagtgggc 1440 agcaagtgtt gcaagcaccc tgaggccaag agaatgcctt gcgccgagga ttacctgagc 1500 gtggtgctga atcagctgtg cgtgctgcac gagaaaaccc ctgtgtccga cagagtgacc 1560 aagtgctgta ccgagagcct cgtgaacaga aggccttgct ttagcgccct ggaagtggac 1620 gagacatacg tgcccaaaga gttcaacgcc gagacattca ccttccacgc cgacatctgc 1680 accctgtccg agaaagagcg gcagatcaag aagcagacag ccctggtcga gctggttaag 1740 cacaagccca aggccaccaa agaacagctg aaggccgtga tggacgactt cgccgccttt 1800 gtcgagaagt gctgcaaggc cgacgacaaa gagacatgct tcgccgaaga gggcaagaaa 1860 ctggtggctg cttctcaggc cgctctgtgt gtggaacccc tcggcatgga aaacggcaat 1920 atcgccaata gccagattgc cgccagcagc gtcagagtga catttctggg actgcaacac 1980 tgggtgcccg agctggctag actgaataga gccggcatgg tcaacgcctg gacacccagc 2040 agcaacgacg ataatccctg gattcaagtg aacctgctgc ggcgtatgtg ggtcacaggt 2100 gttgttacac agggcgcaag cagactggcc agccacgagt atctgaaggc ctttaaggtg 2160 gcctacagcc tgaacggcca cgagttcgac ttcatccacg acgtgaacaa gaagcacaaa 2220 gagtttgtcg gcaactggaa caagaacgcc gtgcacgtga acctgttcga gacacctgtg 2280 gaagcccagt acgtgcggct gtaccctaca agctgtcaca ccgcctgcac tctgagattc 2340 gaactgctgg gatgcgagct gaacggctgt gctaatcctc tgggcctgaa gaacaacagc 2400 atccccgata agcagatcac cgccagctcc agctataaga catggggcct gcacctgttc 2460 agctggaacc cttcttacgc cagactggac aagcagggca acttcaatgc ttgggtggcc 2520 ggcagctacg gcaatgatca gtggctgcaa gtggacctgg gcagcagcaa agaagtgaca 2580 ggcatcatca cccaaggggc cagaaatttc ggcagcgtgc agttcgtggc cagctacaaa 2640 gtggcctact ccaacgacag cgccaactgg accgagtatc aggaccctag aaccggcagc 2700 tccaagatct tccccggcaa ttgggacaac cacagccaca agaagaatct gttcgaaacc 2760 cctatcctgg ccagatatgt gcgcattctg cccgtggcct ggcacaacag aattgccctg 2820 agactggaac tgctcggctg c 2841 <210> 48 <211> 941 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 48 Leu Asp Ile Cys Ser Lys Asn Pro Cys His Asn Gly Gly Leu Cys Glu 1 5 10 15 Glu Ile Ser Gln Glu Val Arg Gly Asp Val Phe Pro Ser Tyr Thr Cys 20 25 30 Thr Cys Leu Lys Gly Tyr Ala Gly Asn His Cys Glu Thr Lys Asp Ala 35 40 45 His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn 50 55 60 Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Ser 65 70 75 80 Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala 85 90 95 Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu 100 105 110 His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu 115 120 125 Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg 130 135 140 Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg 145 150 155 160 Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn 165 170 175 Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His 180 185 190 Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys 195 200 205 Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu 210 215 220 Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala 225 230 235 240 Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala 245 250 255 Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala 260 265 270 Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His 275 280 285 Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala 290 295 300 Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys 305 310 315 320 Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile 325 330 335 Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala 340 345 350 Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala 355 360 365 Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His 370 375 380 Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu 385 390 395 400 Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr 405 410 415 Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn 420 425 430 Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys 435 440 445 Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val 450 455 460 Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly 465 470 475 480 Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu 485 490 495 Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys 500 505 510 Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val 515 520 525 Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val 530 535 540 Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys 545 550 555 560 Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val 565 570 575 Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala 580 585 590 Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp 595 600 605 Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Cys 610 615 620 Val Glu Pro Leu Gly Met Glu Asn Gly Asn Ile Ala Asn Ser Gln Ile 625 630 635 640 Ala Ala Ser Ser Val Arg Val Thr Phe Leu Gly Leu Gln His Trp Val 645 650 655 Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly Met Val Asn Ala Trp Thr 660 665 670 Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile Gln Val Asn Leu Leu Arg 675 680 685 Arg Met Trp Val Thr Gly Val Val Thr Gln Gly Ala Ser Arg Leu Ala 690 695 700 Ser His Glu Tyr Leu Lys Ala Phe Lys Val Ala Tyr Ser Leu Asn Gly 705 710 715 720 His Glu Phe Asp Phe Ile His Asp Val Asn Lys Lys His Lys Glu Phe 725 730 735 Val Gly Asn Trp Asn Lys Asn Ala Val His Val Asn Leu Phe Glu Thr 740 745 750 Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr Pro Thr Ser Cys His Thr 755 760 765 Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly Cys Glu Leu Asn Gly Cys 770 775 780 Ala Asn Pro Leu Gly Leu Lys Asn Asn Ser Ile Pro Asp Lys Gln Ile 785 790 795 800 Thr Ala Ser Ser Ser Tyr Lys Thr Trp Gly Leu His Leu Phe Ser Trp 805 810 815 Asn Pro Ser Tyr Ala Arg Leu Asp Lys Gln Gly Asn Phe Asn Ala Trp 820 825 830 Val Ala Gly Ser Tyr Gly Asn Asp Gln Trp Leu Gln Val Asp Leu Gly 835 840 845 Ser Ser Lys Glu Val Thr Gly Ile Ile Thr Gln Gly Ala Arg Asn Phe 850 855 860 Gly Ser Val Gln Phe Val Ala Ser Tyr Lys Val Ala Tyr Ser Asn Asp 865 870 875 880 Ser Ala Asn Trp Thr Glu Tyr Gln Asp Pro Arg Thr Gly Ser Ser Lys 885 890 895 Ile Phe Pro Gly Asn Trp Asp Asn His Ser His Lys Lys Asn Leu Phe 900 905 910 Glu Thr Pro Ile Leu Ala Arg Tyr Val Arg Ile Leu Pro Val Ala Trp 915 920 925 His Asn Arg Ile Ala Leu Arg Leu Glu Leu Leu Gly Cys 930 935 940 <210> 49 <211> 2823 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 49 ctggacatct gtagcaagaa cccttgccac aacggcggcc tgtgcgaaga gatttctcaa 60 gaagtgcggg gcgacgtttt ccccagctac acctgtacat gtctgaaggg ctacgccggc 120 aaccactgcg agacaaagga tgcccacaag agcgaggtgg cccacagatt caaggatctg 180 ggcgaagaga acttcaaggc cctggtgctg atcgccttcg ctcagtatct ccagcagagc 240 cctttcgagg accacgtgaa gctggtcaac gaagtgaccg agttcgccaa gacctgtgtg 300 gccgatgaga gcgccgagaa ctgtgataag agcctgcaca ccctgttcgg cgacaagctg 360 tgtacagtgg ccacactgag agaaacctac ggcgagatgg ccgactgctg tgccaagcaa 420 gagcccgaga gaaacgagtg cttcctccag cacaaggacg acaaccccaa cctgcctaga 480 ctcgtgcgac ccgaagtgga tgtgatgtgc accgcctttc acgacaacga ggaaaccttc 540 ctgaagaagt acctgtacga gatcgccaga cggcacccct acttttatgc ccctgagctg 600 ctgttcttcg ccaagcggta taaggccgcc ttcaccgaat gttgccaggc cgctgataag 660 gctgcctgtc tgctgcctaa gctggacgag ctgagagatg agggcaaagc cagctctgcc 720 aagcagagac tgaaatgcgc cagcctccag aagttcggcg agagagcttt taaggcctgg 780 gccgttgcca gactgagcca gagatttcct aaggccgagt ttgccgaggt gtccaagctc 840 gtgaccgatc tgacaaaggt gcacaccgag tgctgtcacg gcgatctgct ggaatgtgcc 900 gacgatagag ccgacctggc caagtacatc tgcgagaacc aggacagcat cagcagcaag 960 ctgaaagagt gctgcgagaa gcccctgctg gaaaagtctc actgtatcgc cgaggtggaa 1020 aacgacgaga tgcctgccga tctgcctagc ctggctgccg atttcgtgga aagcaaggac 1080 gtgtgcaaga actacgccga ggccaaggat gtgtttctgg gcatgtttct gtatgagtac 1140 gcccgcagac accccgacta ttctgtggtt ctgctgctgc ggctggccaa aacctacgag 1200 acaaccctgg aaaaatgctg cgccgctgcc gatcctcacg agtgttatgc caaggtgttc 1260 gacgagttca agcctctggt ggaagaaccc cagaacctga tcaagcagaa ctgcgagctg 1320 ttcgagcagc tgggcgagta caagttccag aatgccctgc tcgtgcggta caccaagaaa 1380 gtgcctcagg tgtccacacc tacactggtt gaggtgtccc ggaatctggg caaagtgggc 1440 agcaagtgtt gcaagcaccc tgaggccaag agaatgcctt gcgccgagga ttacctgagc 1500 gtggtgctga atcagctgtg cgtgctgcac gagaaaaccc ctgtgtccga cagagtgacc 1560 aagtgctgta ccgagagcct cgtgaacaga aggccttgct ttagcgccct ggaagtggac 1620 gagacatacg tgcccaaaga gttcaacgcc gagacattca ccttccacgc cgacatctgc 1680 accctgtccg agaaagagcg gcagatcaag aagcagacag ccctggtcga gctggttaag 1740 cacaagccca aggccaccaa agaacagctg aaggccgtga tggacgactt cgccgccttt 1800 gtcgagaagt gctgcaaggc cgacgacaaa gagacatgct tcgccgaaga gggcaagaaa 1860 ctggtggcct gtgtggaacc cctcggcatg gaaaacggca atatcgccaa tagccagatt 1920 gccgccagca gcgtcagagt gacatttctg ggactgcaac actgggtgcc cgagctggct 1980 agactgaata gagccggcat ggtcaacgcc tggacaccca gcagcaacga cgataatccc 2040 tggattcaag tgaacctgct gcggcgtatg tgggtcacag gtgttgttac acagggcgca 2100 agcagactgg ccagccacga gtatctgaag gcctttaagg tggcctacag cctgaacggc 2160 cacgagttcg acttcatcca cgacgtgaac aagaagcaca aagagtttgt cggcaactgg 2220 aacaagaacg ccgtgcacgt gaacctgttc gagacacctg tggaagccca gtacgtgcgg 2280 ctgtacccta caagctgtca caccgcctgc actctgagat tcgaactgct gggatgcgag 2340 ctgaacggct gtgctaatcc tctgggcctg aagaacaaca gcatccccga taagcagatc 2400 accgccagct ccagctataa gacatggggc ctgcacctgt tcagctggaa cccttcttac 2460 gccagactgg acaagcaggg caacttcaat gcttgggtgg ccggcagcta cggcaatgat 2520 cagtggctgc aagtggacct gggcagcagc aaagaagtga caggcatcat cacccaaggg 2580 gccagaaatt tcggcagcgt gcagttcgtg gccagctaca aagtggccta ctccaacgac 2640 agcgccaact ggaccgagta tcaggaccct agaaccggca gctccaagat cttccccggc 2700 aattgggaca accacagcca caagaagaat ctgttcgaaa cccctatcct ggccagatat 2760 gtgcgcattc tgcccgtggc ctggcacaac agaattgccc tgagactgga actgctcggc 2820 tgc 2823 <210> 50 <211> 963 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 50 Leu Asp Ile Cys Ser Lys Asn Pro Cys His Asn Gly Gly Leu Cys Glu 1 5 10 15 Glu Ile Ser Gln Glu Val Arg Gly Asp Val Phe Pro Ser Tyr Thr Cys 20 25 30 Thr Cys Leu Lys Gly Tyr Ala Gly Asn His Cys Glu Thr Lys Gly Ser 35 40 45 Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 50 55 60 Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 65 70 75 80 Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 85 90 95 Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 100 105 110 Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 115 120 125 Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 130 135 140 Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 145 150 155 160 Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 165 170 175 Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 180 185 190 Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 195 200 205 Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 210 215 220 Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 225 230 235 240 Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 245 250 255 Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 260 265 270 Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 275 280 285 Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 290 295 300 Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 305 310 315 320 Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 325 330 335 Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 340 345 350 Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 355 360 365 Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 370 375 380 Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 385 390 395 400 Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 405 410 415 Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 420 425 430 Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 435 440 445 Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 450 455 460 Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 465 470 475 480 Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 485 490 495 Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 500 505 510 Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 515 520 525 Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 530 535 540 Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 545 550 555 560 Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 565 570 575 Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 580 585 590 Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 595 600 605 Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 610 615 620 Ala Ala Ser Gln Ala Ala Leu Gly Val Gly Gly Ser Gly Gly Ser Gly 625 630 635 640 Gly Ser Gly Gly Ser Cys Val Glu Pro Leu Gly Met Glu Asn Gly Asn 645 650 655 Ile Ala Asn Ser Gln Ile Ala Ala Ser Ser Val Arg Val Thr Phe Leu 660 665 670 Gly Leu Gln His Trp Val Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly 675 680 685 Met Val Asn Ala Trp Thr Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile 690 695 700 Gln Val Asn Leu Leu Arg Arg Met Trp Val Thr Gly Val Val Thr Gln 705 710 715 720 Gly Ala Ser Arg Leu Ala Ser His Glu Tyr Leu Lys Ala Phe Lys Val 725 730 735 Ala Tyr Ser Leu Asn Gly His Glu Phe Asp Phe Ile His Asp Val Asn 740 745 750 Lys Lys His Lys Glu Phe Val Gly Asn Trp Asn Lys Asn Ala Val His 755 760 765 Val Asn Leu Phe Glu Thr Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr 770 775 780 Pro Thr Ser Cys His Thr Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly 785 790 795 800 Cys Glu Leu Asn Gly Cys Ala Asn Pro Leu Gly Leu Lys Asn Asn Ser 805 810 815 Ile Pro Asp Lys Gln Ile Thr Ala Ser Ser Ser Tyr Lys Thr Trp Gly 820 825 830 Leu His Leu Phe Ser Trp Asn Pro Ser Tyr Ala Arg Leu Asp Lys Gln 835 840 845 Gly Asn Phe Asn Ala Trp Val Ala Gly Ser Tyr Gly Asn Asp Gln Trp 850 855 860 Leu Gln Val Asp Leu Gly Ser Ser Lys Glu Val Thr Gly Ile Ile Thr 865 870 875 880 Gln Gly Ala Arg Asn Phe Gly Ser Val Gln Phe Val Ala Ser Tyr Lys 885 890 895 Val Ala Tyr Ser Asn Asp Ser Ala Asn Trp Thr Glu Tyr Gln Asp Pro 900 905 910 Arg Thr Gly Ser Ser Lys Ile Phe Pro Gly Asn Trp Asp Asn His Ser 915 920 925 His Lys Lys Asn Leu Phe Glu Thr Pro Ile Leu Ala Arg Tyr Val Arg 930 935 940 Ile Leu Pro Val Ala Trp His Asn Arg Ile Ala Leu Arg Leu Glu Leu 945 950 955 960 Leu Gly Cys <210> 51 <211> 2889 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 51 ctggacatct gcagcaagaa tccttgccac aacggcggcc tgtgcgaaga gatttctcaa 60 gaagtgcggg gcgacgtttt ccccagctac acctgtacat gtctgaaggg ctacgccggc 120 aaccactgcg agacaaaagg atccgatgct cacaagagcg aggtggccca cagattcaag 180 gatctgggcg aagagaactt caaggccctg gtgctgatcg ccttcgctca gtatctccag 240 cagagccctt tcgaggacca cgtgaagctg gtcaacgaag tgaccgagtt cgccaagacc 300 tgtgtggccg atgagagcgc cgagaactgt gataagagcc tgcacaccct gttcggcgac 360 aagctgtgta cagtggccac actgagagaa acctacggcg agatggccga ctgctgtgcc 420 aagcaagagc ccgagagaaa cgagtgcttc ctgcagcaca aggacgacaa ccccaacctg 480 cctagactcg tgcgacccga agtggatgtg atgtgcaccg cctttcacga caacgaggaa 540 accttcctga agaagtacct gtacgagatc gccagacggc acccctactt ttatgcccct 600 gagctgctgt tcttcgccaa gcggtataag gccgccttca ccgaatgttg ccaggccgct 660 gataaggctg cctgtctgct gcctaagctg gacgagctga gagatgaggg caaagccagc 720 tctgccaagc agagactgaa gtgcgccagc ctgcagaagt tcggcgagag agcttttaag 780 gcctgggccg ttgccagact gagccagaga tttcctaagg ccgagtttgc cgaggtgtcc 840 aagctcgtga ccgatctgac aaaggtgcac accgagtgct gtcacggcga tctgctggaa 900 tgtgccgacg atagagccga cctggccaag tacatctgcg agaaccagga cagcatcagc 960 agcaagctga aagagtgctg cgagaagccc ctgctggaaa agtctcactg tatcgccgag 1020 gtggaaaacg acgagatgcc tgccgatctg cctagcctgg ctgccgattt cgtggaaagc 1080 aaggacgtgt gcaagaacta cgccgaggcc aaggatgtgt ttctgggcat gtttctgtat 1140 gagtacgccc gcagacaccc cgactattct gtggttctgc tgctgcggct ggccaaaacc 1200 tacgagacaa ccctggaaaa atgctgcgcc gctgccgatc ctcacgagtg ttatgccaag 1260 gtgttcgacg agttcaagcc tctggtggaa gaaccccaga acctgatcaa gcagaactgc 1320 gagctgttcg agcagctggg cgagtacaag ttccagaatg ccctgctcgt gcggtacacc 1380 aagaaagtgc ctcaggtgtc cacacctaca ctggttgagg tgtcccggaa tctgggcaaa 1440 gtgggcagca agtgttgcaa gcaccctgag gccaagagaa tgccttgcgc cgaggattac 1500 ctgagcgtgg tgctgaatca gctgtgcgtg ctgcacgaga aaacccctgt gtccgacaga 1560 gtgaccaagt gctgtaccga gagcctcgtg aacagaaggc cttgctttag cgccctggaa 1620 gtggacgaga catacgtgcc caaagagttc aacgccgaga cattcacctt ccacgccgac 1680 atctgtaccc tgagcgagaa agagcggcag atcaagaagc agacagccct ggtcgagctg 1740 gttaagcaca agcccaaggc caccaaagaa cagctgaagg ccgtgatgga cgacttcgcc 1800 gcctttgtcg agaagtgctg caaggccgac gacaaagaga catgcttcgc cgaagagggc 1860 aagaaactgg tggctgcctc tcaggctgct ctcggagtgg gaggaagcgg aggatctggc 1920 ggttccggag gctcttgtgt ggaacccctc ggcatggaaa acggcaatat cgccaatagc 1980 cagattgccg ccagcagcgt cagagtgaca tttctgggac tgcagcactg ggtgcccgag 2040 ctggctagac tgaatagagc cggcatggtc aacgcctgga cacccagcag caacgacgat 2100 aacccttgga ttcaagtgaa cctgctgcgg cgtatgtggg tcacaggtgt tgttacacag 2160 ggcgcctcta gactggccag ccacgagtat ctgaaggcct ttaaggtggc ctacagcctg 2220 aacggccacg agttcgactt catccacgac gtgaacaaga agcacaaaga gtttgtcggc 2280 aactggaaca agaacgccgt gcacgtgaac ctgttcgaga cacctgtgga agcccagtac 2340 gtgcggctgt accctacaag ctgtcacacc gcctgcactc tgagattcga actgctggga 2400 tgcgagctga acggctgtgc taatcctctg ggcctgaaga acaacagcat ccccgataag 2460 cagatcaccg ccagctccag ctataagaca tggggcctgc acctgttcag ctggaaccct 2520 tcttacgcca gactggacaa gcagggcaac ttcaatgctt gggtggccgg cagctacggc 2580 aatgatcagt ggctgcaagt ggacctgggc agcagcaaag aagtgacagg catcatcacc 2640 cagggcgcca gaaatttcgg cagcgtgcag tttgtggcca gctacaaagt ggcctactcc 2700 aacgacagcg ccaactggac cgagtatcag gaccctagaa ccggcagctc caagatcttc 2760 cccggcaatt gggacaacca cagccacaag aagaatctgt tcgaaacccc tatcctggcc 2820 agatatgtgc gcattctgcc cgtggcctgg cacaacagaa ttgccctgag actggaactg 2880 ctcggctgt 2889 <210> 52 <211> 961 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 52 Leu Asp Ile Cys Ser Lys Asn Pro Cys His Asn Gly Gly Leu Cys Glu 1 5 10 15 Glu Ile Ser Gln Glu Val Arg Gly Asp Val Phe Pro Ser Tyr Thr Cys 20 25 30 Thr Cys Leu Lys Gly Tyr Ala Gly Asn His Cys Glu Thr Lys Gly Ser 35 40 45 Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 50 55 60 Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 65 70 75 80 Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 85 90 95 Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 100 105 110 Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 115 120 125 Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 130 135 140 Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 145 150 155 160 Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 165 170 175 Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 180 185 190 Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 195 200 205 Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 210 215 220 Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 225 230 235 240 Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 245 250 255 Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 260 265 270 Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 275 280 285 Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 290 295 300 Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 305 310 315 320 Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 325 330 335 Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 340 345 350 Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 355 360 365 Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 370 375 380 Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 385 390 395 400 Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 405 410 415 Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 420 425 430 Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 435 440 445 Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 450 455 460 Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 465 470 475 480 Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 485 490 495 Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 500 505 510 Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 515 520 525 Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 530 535 540 Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 545 550 555 560 Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 565 570 575 Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 580 585 590 Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 595 600 605 Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 610 615 620 Ala Ala Ser Gln Ala Ala Leu Gly Gly Ser Gly Gly Ser Gly Gly Ser 625 630 635 640 Gly Gly Ser Cys Val Glu Pro Leu Gly Met Glu Asn Gly Asn Ile Ala 645 650 655 Asn Ser Gln Ile Ala Ala Ser Ser Val Arg Val Thr Phe Leu Gly Leu 660 665 670 Gln His Trp Val Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly Met Val 675 680 685 Asn Ala Trp Thr Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile Gln Val 690 695 700 Asn Leu Leu Arg Arg Met Trp Val Thr Gly Val Val Thr Gln Gly Ala 705 710 715 720 Ser Arg Leu Ala Ser His Glu Tyr Leu Lys Ala Phe Lys Val Ala Tyr 725 730 735 Ser Leu Asn Gly His Glu Phe Asp Phe Ile His Asp Val Asn Lys Lys 740 745 750 His Lys Glu Phe Val Gly Asn Trp Asn Lys Asn Ala Val His Val Asn 755 760 765 Leu Phe Glu Thr Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr Pro Thr 770 775 780 Ser Cys His Thr Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly Cys Glu 785 790 795 800 Leu Asn Gly Cys Ala Asn Pro Leu Gly Leu Lys Asn Asn Ser Ile Pro 805 810 815 Asp Lys Gln Ile Thr Ala Ser Ser Ser Tyr Lys Thr Trp Gly Leu His 820 825 830 Leu Phe Ser Trp Asn Pro Ser Tyr Ala Arg Leu Asp Lys Gln Gly Asn 835 840 845 Phe Asn Ala Trp Val Ala Gly Ser Tyr Gly Asn Asp Gln Trp Leu Gln 850 855 860 Val Asp Leu Gly Ser Ser Lys Glu Val Thr Gly Ile Ile Thr Gln Gly 865 870 875 880 Ala Arg Asn Phe Gly Ser Val Gln Phe Val Ala Ser Tyr Lys Val Ala 885 890 895 Tyr Ser Asn Asp Ser Ala Asn Trp Thr Glu Tyr Gln Asp Pro Arg Thr 900 905 910 Gly Ser Ser Lys Ile Phe Pro Gly Asn Trp Asp Asn His Ser His Lys 915 920 925 Lys Asn Leu Phe Glu Thr Pro Ile Leu Ala Arg Tyr Val Arg Ile Leu 930 935 940 Pro Val Ala Trp His Asn Arg Ile Ala Leu Arg Leu Glu Leu Leu Gly 945 950 955 960 Cys <210> 53 <211> 2883 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 53 ctggacatct gcagcaagaa tccttgccac aacggcggcc tgtgcgaaga gatttctcaa 60 gaagtgcggg gcgacgtttt ccccagctac acctgtacat gtctgaaggg ctacgccggc 120 aaccactgcg agacaaaagg atccgatgct cacaagagcg aggtggccca cagattcaag 180 gatctgggcg aagagaactt caaggccctg gtgctgatcg ccttcgctca gtatctccag 240 cagagccctt tcgaggacca cgtgaagctg gtcaacgaag tgaccgagtt cgccaagacc 300 tgtgtggccg atgagagcgc cgagaactgt gataagagcc tgcacaccct gttcggcgac 360 aagctgtgta cagtggccac actgagagaa acctacggcg agatggccga ctgctgtgcc 420 aagcaagagc ccgagagaaa cgagtgcttc ctgcagcaca aggacgacaa ccccaacctg 480 cctagactcg tgcgacccga agtggatgtg atgtgcaccg cctttcacga caacgaggaa 540 accttcctga agaagtacct gtacgagatc gccagacggc acccctactt ttatgcccct 600 gagctgctgt tcttcgccaa gcggtataag gccgccttca ccgaatgttg ccaggccgct 660 gataaggctg cctgtctgct gcctaagctg gacgagctga gagatgaggg caaagccagc 720 tctgccaagc agagactgaa gtgcgccagc ctgcagaagt tcggcgagag agcttttaag 780 gcctgggccg ttgccagact gagccagaga tttcctaagg ccgagtttgc cgaggtgtcc 840 aagctcgtga ccgatctgac aaaggtgcac accgagtgct gtcacggcga tctgctggaa 900 tgtgccgacg atagagccga cctggccaag tacatctgcg agaaccagga cagcatcagc 960 agcaagctga aagagtgctg cgagaagccc ctgctggaaa agtctcactg tatcgccgag 1020 gtggaaaacg acgagatgcc tgccgatctg cctagcctgg ctgccgattt cgtggaaagc 1080 aaggacgtgt gcaagaacta cgccgaggcc aaggatgtgt ttctgggcat gtttctgtat 1140 gagtacgccc gcagacaccc cgactattct gtggttctgc tgctgcggct ggccaaaacc 1200 tacgagacaa ccctggaaaa atgctgcgcc gctgccgatc ctcacgagtg ttatgccaag 1260 gtgttcgacg agttcaagcc tctggtggaa gaaccccaga acctgatcaa gcagaactgc 1320 gagctgttcg agcagctggg cgagtacaag ttccagaatg ccctgctcgt gcggtacacc 1380 aagaaagtgc ctcaggtgtc cacacctaca ctggttgagg tgtcccggaa tctgggcaaa 1440 gtgggcagca agtgttgcaa gcaccctgag gccaagagaa tgccttgcgc cgaggattac 1500 ctgagcgtgg tgctgaatca gctgtgcgtg ctgcacgaga aaacccctgt gtccgacaga 1560 gtgaccaagt gctgtaccga gagcctcgtg aacagaaggc cttgctttag cgccctggaa 1620 gtggacgaga catacgtgcc caaagagttc aacgccgaga cattcacctt ccacgccgac 1680 atctgtaccc tgagcgagaa agagcggcag atcaagaagc agacagccct ggtcgagctg 1740 gttaagcaca agcccaaggc caccaaagaa cagctgaagg ccgtgatgga cgacttcgcc 1800 gcctttgtcg agaagtgctg caaggccgac gacaaagaga catgcttcgc cgaagagggc 1860 aagaaactgg tggctgcctc tcaggctgct ctcggaggaa gcggaggatc tggcggttcc 1920 ggaggctctt gtgtggaacc cctcggcatg gaaaacggca atatcgccaa tagccagatt 1980 gccgccagca gcgtcagagt gacatttctg ggactgcagc actgggtgcc cgagctggct 2040 agactgaata gagccggcat ggtcaacgcc tggacaccca gcagcaacga cgataaccct 2100 tggattcaag tgaacctgct gcggcgtatg tgggtcacag gtgttgttac acagggcgcc 2160 tctagactgg ccagccacga gtatctgaag gcctttaagg tggcctacag cctgaacggc 2220 cacgagttcg acttcatcca cgacgtgaac aagaagcaca aagagtttgt cggcaactgg 2280 aacaagaacg ccgtgcacgt gaacctgttc gagacacctg tggaagccca gtacgtgcgg 2340 ctgtacccta caagctgtca caccgcctgc actctgagat tcgaactgct gggatgcgag 2400 ctgaacggct gtgctaatcc tctgggcctg aagaacaaca gcatccccga taagcagatc 2460 accgccagct ccagctataa gacatggggc ctgcacctgt tcagctggaa cccttcttac 2520 gccagactgg acaagcaggg caacttcaat gcttgggtgg ccggcagcta cggcaatgat 2580 cagtggctgc aagtggacct gggcagcagc aaagaagtga caggcatcat cacccagggc 2640 gccagaaatt tcggcagcgt gcagtttgtg gccagctaca aagtggccta ctccaacgac 2700 agcgccaact ggaccgagta tcaggaccct agaaccggca gctccaagat cttccccggc 2760 aattgggaca accacagcca caagaagaat ctgttcgaaa cccctatcct ggccagatat 2820 gtgcgcattc tgcccgtggc ctggcacaac agaattgccc tgagactgga actgctcggc 2880 tgt 2883 <210> 54 <211> 954 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 54 Leu Asp Ile Cys Ser Lys Asn Pro Cys His Asn Gly Gly Leu Cys Glu 1 5 10 15 Glu Ile Ser Gln Glu Val Arg Gly Asp Val Phe Pro Ser Tyr Thr Cys 20 25 30 Thr Cys Leu Lys Gly Tyr Ala Gly Asn His Cys Glu Thr Lys Gly Ser 35 40 45 Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 50 55 60 Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 65 70 75 80 Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 85 90 95 Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 100 105 110 Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 115 120 125 Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 130 135 140 Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 145 150 155 160 Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 165 170 175 Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 180 185 190 Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 195 200 205 Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 210 215 220 Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 225 230 235 240 Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 245 250 255 Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 260 265 270 Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 275 280 285 Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 290 295 300 Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 305 310 315 320 Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 325 330 335 Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 340 345 350 Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 355 360 365 Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 370 375 380 Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 385 390 395 400 Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 405 410 415 Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 420 425 430 Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 435 440 445 Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 450 455 460 Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 465 470 475 480 Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 485 490 495 Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 500 505 510 Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 515 520 525 Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 530 535 540 Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 545 550 555 560 Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 565 570 575 Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 580 585 590 Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 595 600 605 Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 610 615 620 Ala Ala Ser Gln Ala Ala Leu Gly Gly Gly Gly Ser Cys Val Glu Pro 625 630 635 640 Leu Gly Met Glu Asn Gly Asn Ile Ala Asn Ser Gln Ile Ala Ala Ser 645 650 655 Ser Val Arg Val Thr Phe Leu Gly Leu Gln His Trp Val Pro Glu Leu 660 665 670 Ala Arg Leu Asn Arg Ala Gly Met Val Asn Ala Trp Thr Pro Ser Ser 675 680 685 Asn Asp Asp Asn Pro Trp Ile Gln Val Asn Leu Leu Arg Arg Met Trp 690 695 700 Val Thr Gly Val Val Thr Gln Gly Ala Ser Arg Leu Ala Ser His Glu 705 710 715 720 Tyr Leu Lys Ala Phe Lys Val Ala Tyr Ser Leu Asn Gly His Glu Phe 725 730 735 Asp Phe Ile His Asp Val Asn Lys Lys His Lys Glu Phe Val Gly Asn 740 745 750 Trp Asn Lys Asn Ala Val His Val Asn Leu Phe Glu Thr Pro Val Glu 755 760 765 Ala Gln Tyr Val Arg Leu Tyr Pro Thr Ser Cys His Thr Ala Cys Thr 770 775 780 Leu Arg Phe Glu Leu Leu Gly Cys Glu Leu Asn Gly Cys Ala Asn Pro 785 790 795 800 Leu Gly Leu Lys Asn Asn Ser Ile Pro Asp Lys Gln Ile Thr Ala Ser 805 810 815 Ser Ser Tyr Lys Thr Trp Gly Leu His Leu Phe Ser Trp Asn Pro Ser 820 825 830 Tyr Ala Arg Leu Asp Lys Gln Gly Asn Phe Asn Ala Trp Val Ala Gly 835 840 845 Ser Tyr Gly Asn Asp Gln Trp Leu Gln Val Asp Leu Gly Ser Ser Lys 850 855 860 Glu Val Thr Gly Ile Ile Thr Gln Gly Ala Arg Asn Phe Gly Ser Val 865 870 875 880 Gln Phe Val Ala Ser Tyr Lys Val Ala Tyr Ser Asn Asp Ser Ala Asn 885 890 895 Trp Thr Glu Tyr Gln Asp Pro Arg Thr Gly Ser Ser Lys Ile Phe Pro 900 905 910 Gly Asn Trp Asp Asn His Ser His Lys Lys Asn Leu Phe Glu Thr Pro 915 920 925 Ile Leu Ala Arg Tyr Val Arg Ile Leu Pro Val Ala Trp His Asn Arg 930 935 940 Ile Ala Leu Arg Leu Glu Leu Leu Gly Cys 945 950 <210> 55 <211> 2862 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 55 ctggacatct gcagcaagaa tccttgccac aacggcggcc tgtgcgaaga gatttctcaa 60 gaagtgcggg gcgacgtttt ccccagctac acctgtacat gtctgaaggg ctacgccggc 120 aaccactgcg agacaaaagg atccgatgct cacaagagcg aggtggccca cagattcaag 180 gatctgggcg aagagaactt caaggccctg gtgctgatcg ccttcgctca gtatctccag 240 cagagccctt tcgaggacca cgtgaagctg gtcaacgaag tgaccgagtt cgccaagacc 300 tgtgtggccg atgagagcgc cgagaactgt gataagagcc tgcacaccct gttcggcgac 360 aagctgtgta cagtggccac actgagagaa acctacggcg agatggccga ctgctgtgcc 420 aagcaagagc ccgagagaaa cgagtgcttc ctgcagcaca aggacgacaa ccccaacctg 480 cctagactcg tgcgacccga agtggatgtg atgtgcaccg cctttcacga caacgaggaa 540 accttcctga agaagtacct gtacgagatc gccagacggc acccctactt ttatgcccct 600 gagctgctgt tcttcgccaa gcggtataag gccgccttca ccgaatgttg ccaggccgct 660 gataaggctg cctgtctgct gcctaagctg gacgagctga gagatgaggg caaagccagc 720 tctgccaagc agagactgaa gtgcgccagc ctgcagaagt tcggcgagag agcttttaag 780 gcctgggccg ttgccagact gagccagaga tttcctaagg ccgagtttgc cgaggtgtcc 840 aagctcgtga ccgatctgac aaaggtgcac accgagtgct gtcacggcga tctgctggaa 900 tgtgccgacg atagagccga cctggccaag tacatctgcg agaaccagga cagcatcagc 960 agcaagctga aagagtgctg cgagaagccc ctgctggaaa agtctcactg tatcgccgag 1020 gtggaaaacg acgagatgcc tgccgatctg cctagcctgg ctgccgattt cgtggaaagc 1080 aaggacgtgt gcaagaacta cgccgaggcc aaggatgtgt ttctgggcat gtttctgtat 1140 gagtacgccc gcagacaccc cgactattct gtggttctgc tgctgcggct ggccaaaacc 1200 tacgagacaa ccctggaaaa atgctgcgcc gctgccgatc ctcacgagtg ttatgccaag 1260 gtgttcgacg agttcaagcc tctggtggaa gaaccccaga acctgatcaa gcagaactgc 1320 gagctgttcg agcagctggg cgagtacaag ttccagaatg ccctgctcgt gcggtacacc 1380 aagaaagtgc ctcaggtgtc cacacctaca ctggttgagg tgtcccggaa tctgggcaaa 1440 gtgggcagca agtgttgcaa gcaccctgag gccaagagaa tgccttgcgc cgaggattac 1500 ctgagcgtgg tgctgaatca gctgtgcgtg ctgcacgaga aaacccctgt gtccgacaga 1560 gtgaccaagt gctgtaccga gagcctcgtg aacagaaggc cttgctttag cgccctggaa 1620 gtggacgaga catacgtgcc caaagagttc aacgccgaga cattcacctt ccacgccgac 1680 atctgtaccc tgagcgagaa agagcggcag atcaagaagc agacagccct ggtcgagctg 1740 gttaagcaca agcccaaggc caccaaagaa cagctgaagg ccgtgatgga cgacttcgcc 1800 gcctttgtcg agaagtgctg caaggccgac gacaaagaga catgcttcgc cgaagagggc 1860 aagaaactgg tggctgcctc tcaagctgct ctcggaggcg gaggatcttg tgtggaaccc 1920 ctcggcatgg aaaacggcaa tatcgccaat agccagattg ccgccagcag cgtcagagtg 1980 acatttctgg gactgcagca ctgggtgccc gagctggcta gactgaatag agccggcatg 2040 gtcaacgcct ggacacccag cagcaacgac gataaccctt ggattcaagt gaacctgctg 2100 cggcgtatgt gggtcacagg tgttgttaca cagggcgcct ctagactggc cagccacgag 2160 tatctgaagg cctttaaggt ggcctacagc ctgaacggcc acgagttcga cttcatccac 2220 gacgtgaaca agaagcacaa agagtttgtc ggcaactgga acaagaacgc cgtgcacgtg 2280 aacctgttcg agacacctgt ggaagcccag tacgtgcggc tgtaccctac aagctgtcac 2340 accgcctgca ctctgagatt cgaactgctg ggatgcgagc tgaacggctg tgctaatcct 2400 ctgggcctga agaacaacag catccccgat aagcagatca ccgccagctc cagctataag 2460 acatggggcc tgcacctgtt cagctggaac ccttcttacg ccagactgga caagcagggc 2520 aacttcaatg cttgggtggc cggcagctac ggcaatgatc agtggctgca agtggacctg 2580 ggcagcagca aagaagtgac aggcatcatc acccagggcg ccagaaattt cggcagcgtg 2640 cagtttgtgg ccagctacaa agtggcctac tccaacgaca gcgccaactg gaccgagtat 2700 caggacccta gaaccggcag ctccaagatc ttccccggca attgggacaa ccacagccac 2760 aagaagaatc tgttcgaaac ccctatcctg gccagatatg tgcgcattct gcccgtggcc 2820 tggcacaaca gaattgccct gagactggaa ctgctcggct gc 2862 <210> 56 <211> 959 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 56 Leu Asp Ile Cys Ser Lys Asn Pro Cys His Asn Gly Gly Leu Cys Glu 1 5 10 15 Glu Ile Ser Gln Glu Val Arg Gly Asp Val Phe Pro Ser Tyr Thr Cys 20 25 30 Thr Cys Leu Lys Gly Tyr Ala Gly Asn His Cys Glu Thr Lys Gly Ser 35 40 45 Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 50 55 60 Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 65 70 75 80 Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 85 90 95 Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 100 105 110 Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 115 120 125 Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 130 135 140 Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 145 150 155 160 Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 165 170 175 Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 180 185 190 Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 195 200 205 Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 210 215 220 Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 225 230 235 240 Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 245 250 255 Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 260 265 270 Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 275 280 285 Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 290 295 300 Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 305 310 315 320 Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 325 330 335 Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 340 345 350 Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 355 360 365 Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 370 375 380 Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 385 390 395 400 Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 405 410 415 Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 420 425 430 Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 435 440 445 Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 450 455 460 Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 465 470 475 480 Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 485 490 495 Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 500 505 510 Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 515 520 525 Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 530 535 540 Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 545 550 555 560 Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 565 570 575 Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 580 585 590 Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 595 600 605 Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 610 615 620 Ala Ala Ser Gln Ala Ala Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly 625 630 635 640 Ser Cys Val Glu Pro Leu Gly Met Glu Asn Gly Asn Ile Ala Asn Ser 645 650 655 Gln Ile Ala Ala Ser Ser Val Arg Val Thr Phe Leu Gly Leu Gln His 660 665 670 Trp Val Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly Met Val Asn Ala 675 680 685 Trp Thr Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile Gln Val Asn Leu 690 695 700 Leu Arg Arg Met Trp Val Thr Gly Val Val Thr Gln Gly Ala Ser Arg 705 710 715 720 Leu Ala Ser His Glu Tyr Leu Lys Ala Phe Lys Val Ala Tyr Ser Leu 725 730 735 Asn Gly His Glu Phe Asp Phe Ile His Asp Val Asn Lys Lys His Lys 740 745 750 Glu Phe Val Gly Asn Trp Asn Lys Asn Ala Val His Val Asn Leu Phe 755 760 765 Glu Thr Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr Pro Thr Ser Cys 770 775 780 His Thr Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly Cys Glu Leu Asn 785 790 795 800 Gly Cys Ala Asn Pro Leu Gly Leu Lys Asn Asn Ser Ile Pro Asp Lys 805 810 815 Gln Ile Thr Ala Ser Ser Ser Tyr Lys Thr Trp Gly Leu His Leu Phe 820 825 830 Ser Trp Asn Pro Ser Tyr Ala Arg Leu Asp Lys Gln Gly Asn Phe Asn 835 840 845 Ala Trp Val Ala Gly Ser Tyr Gly Asn Asp Gln Trp Leu Gln Val Asp 850 855 860 Leu Gly Ser Ser Lys Glu Val Thr Gly Ile Ile Thr Gln Gly Ala Arg 865 870 875 880 Asn Phe Gly Ser Val Gln Phe Val Ala Ser Tyr Lys Val Ala Tyr Ser 885 890 895 Asn Asp Ser Ala Asn Trp Thr Glu Tyr Gln Asp Pro Arg Thr Gly Ser 900 905 910 Ser Lys Ile Phe Pro Gly Asn Trp Asp Asn His Ser His Lys Lys Asn 915 920 925 Leu Phe Glu Thr Pro Ile Leu Ala Arg Tyr Val Arg Ile Leu Pro Val 930 935 940 Ala Trp His Asn Arg Ile Ala Leu Arg Leu Glu Leu Leu Gly Cys 945 950 955 <210> 57 <211> 2877 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 57 ctggacatct gcagcaagaa tccttgccac aacggcggcc tgtgcgaaga gatttctcaa 60 gaagtgcggg gcgacgtttt ccccagctac acctgtacat gtctgaaggg ctacgccggc 120 aaccactgcg agacaaaagg atccgatgct cacaagagcg aggtggccca cagattcaag 180 gatctgggcg aagagaactt caaggccctg gtgctgatcg ccttcgctca gtatctccag 240 cagagccctt tcgaggacca cgtgaagctg gtcaacgaag tgaccgagtt cgccaagacc 300 tgtgtggccg atgagagcgc cgagaactgt gataagagcc tgcacaccct gttcggcgac 360 aagctgtgta cagtggccac actgagagaa acctacggcg agatggccga ctgctgtgcc 420 aagcaagagc ccgagagaaa cgagtgcttc ctgcagcaca aggacgacaa ccccaacctg 480 cctagactcg tgcgacccga agtggatgtg atgtgcaccg cctttcacga caacgaggaa 540 accttcctga agaagtacct gtacgagatc gccagacggc acccctactt ttatgcccct 600 gagctgctgt tcttcgccaa gcggtataag gccgccttca ccgaatgttg ccaggccgct 660 gataaggctg cctgtctgct gcctaagctg gacgagctga gagatgaggg caaagccagc 720 tctgccaagc agagactgaa gtgcgccagc ctgcagaagt tcggcgagag agcttttaag 780 gcctgggccg ttgccagact gagccagaga tttcctaagg ccgagtttgc cgaggtgtcc 840 aagctcgtga ccgatctgac aaaggtgcac accgagtgct gtcacggcga tctgctggaa 900 tgtgccgacg atagagccga cctggccaag tacatctgcg agaaccagga cagcatcagc 960 agcaagctga aagagtgctg cgagaagccc ctgctggaaa agtctcactg tatcgccgag 1020 gtggaaaacg acgagatgcc tgccgatctg cctagcctgg ctgccgattt cgtggaaagc 1080 aaggacgtgt gcaagaacta cgccgaggcc aaggatgtgt ttctgggcat gtttctgtat 1140 gagtacgccc gcagacaccc cgactattct gtggttctgc tgctgcggct ggccaaaacc 1200 tacgagacaa ccctggaaaa atgctgcgcc gctgccgatc ctcacgagtg ttatgccaag 1260 gtgttcgacg agttcaagcc tctggtggaa gaaccccaga acctgatcaa gcagaactgc 1320 gagctgttcg agcagctggg cgagtacaag ttccagaatg ccctgctcgt gcggtacacc 1380 aagaaagtgc ctcaggtgtc cacacctaca ctggttgagg tgtcccggaa tctgggcaaa 1440 gtgggcagca agtgttgcaa gcaccctgag gccaagagaa tgccttgcgc cgaggattac 1500 ctgagcgtgg tgctgaatca gctgtgcgtg ctgcacgaga aaacccctgt gtccgacaga 1560 gtgaccaagt gctgtaccga gagcctcgtg aacagaaggc cttgctttag cgccctggaa 1620 gtggacgaga catacgtgcc caaagagttc aacgccgaga cattcacctt ccacgccgac 1680 atctgtaccc tgagcgagaa agagcggcag atcaagaagc agacagccct ggtcgagctg 1740 gttaagcaca agcccaaggc caccaaagaa cagctgaagg ccgtgatgga cgacttcgcc 1800 gcctttgtcg agaagtgctg caaggccgac gacaaagaga catgcttcgc cgaagagggc 1860 aagaaactgg tggctgcctc tcaagctgct ctcggaggcg gaggctccgg aggcggagga 1920 tcttgtgtgg aacccctcgg catggaaaac ggcaatatcg ccaatagcca gattgccgcc 1980 agcagcgtca gagtgacatt tctgggactg cagcactggg tgcccgagct ggctagactg 2040 aatagagccg gcatggtcaa cgcctggaca cccagcagca acgacgataa cccttggatt 2100 caagtgaacc tgctgcggcg tatgtgggtc acaggtgttg ttacacaggg cgcctctaga 2160 ctggccagcc acgagtatct gaaggccttt aaggtggcct acagcctgaa cggccacgag 2220 ttcgacttca tccacgacgt gaacaagaag cacaaagagt ttgtcggcaa ctggaacaag 2280 aacgccgtgc acgtgaacct gttcgagaca cctgtggaag cccagtacgt gcggctgtac 2340 cctacaagct gtcacaccgc ctgcactctg agattcgaac tgctgggatg cgagctgaac 2400 ggctgtgcta atcctctggg cctgaagaac aacagcatcc ccgataagca gatcaccgcc 2460 agctccagct ataagacatg gggcctgcac ctgttcagct ggaacccttc ttacgccaga 2520 ctggacaagc agggcaactt caatgcttgg gtggccggca gctacggcaa tgatcagtgg 2580 ctgcaagtgg acctgggcag cagcaaagaa gtgacaggca tcatcaccca gggcgccaga 2640 aatttcggca gcgtgcagtt tgtggccagc tacaaagtgg cctactccaa cgacagcgcc 2700 aactggaccg agtatcagga ccctagaacc ggcagctcca agatcttccc cggcaattgg 2760 gacaaccaca gccacaagaa gaatctgttc gaaaccccta tcctggccag atatgtgcgc 2820 attctgcccg tggcctggca caacagaatt gccctgagac tggaactgct cggctgc 2877 <210> 58 <211> 949 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 58 Leu Asp Ile Cys Ser Lys Asn Pro Cys His Asn Gly Gly Leu Cys Glu 1 5 10 15 Glu Ile Ser Gln Glu Val Arg Gly Asp Val Phe Pro Ser Tyr Thr Cys 20 25 30 Thr Cys Leu Lys Gly Tyr Ala Gly Asn His Cys Glu Thr Lys Asp Ala 35 40 45 His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn 50 55 60 Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Ser 65 70 75 80 Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala 85 90 95 Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu 100 105 110 His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu 115 120 125 Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg 130 135 140 Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg 145 150 155 160 Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn 165 170 175 Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His 180 185 190 Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys 195 200 205 Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu 210 215 220 Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala 225 230 235 240 Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala 245 250 255 Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala 260 265 270 Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His 275 280 285 Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala 290 295 300 Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys 305 310 315 320 Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile 325 330 335 Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala 340 345 350 Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala 355 360 365 Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His 370 375 380 Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu 385 390 395 400 Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr 405 410 415 Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn 420 425 430 Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys 435 440 445 Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val 450 455 460 Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly 465 470 475 480 Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu 485 490 495 Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys 500 505 510 Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val 515 520 525 Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val 530 535 540 Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys 545 550 555 560 Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val 565 570 575 Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala 580 585 590 Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp 595 600 605 Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala 610 615 620 Ser Gln Ala Ala Leu Gly Leu Cys Val Glu Pro Leu Gly Met Glu Asn 625 630 635 640 Gly Asn Ile Ala Asn Ser Gln Ile Ala Ala Ser Ser Val Arg Val Thr 645 650 655 Phe Leu Gly Leu Gln His Trp Val Pro Glu Leu Ala Arg Leu Asn Arg 660 665 670 Ala Gly Met Val Asn Ala Trp Thr Pro Ser Ser Asn Asp Asp Asn Pro 675 680 685 Trp Ile Gln Val Asn Leu Leu Arg Arg Met Trp Val Thr Gly Val Val 690 695 700 Thr Gln Gly Ala Ser Arg Leu Ala Ser His Glu Tyr Leu Lys Ala Phe 705 710 715 720 Lys Val Ala Tyr Ser Leu Asn Gly His Glu Phe Asp Phe Ile His Asp 725 730 735 Val Asn Lys Lys His Lys Glu Phe Val Gly Asn Trp Asn Lys Asn Ala 740 745 750 Val His Val Asn Leu Phe Glu Thr Pro Val Glu Ala Gln Tyr Val Arg 755 760 765 Leu Tyr Pro Thr Ser Cys His Thr Ala Cys Thr Leu Arg Phe Glu Leu 770 775 780 Leu Gly Cys Glu Leu Asn Gly Cys Ala Asn Pro Leu Gly Leu Lys Asn 785 790 795 800 Asn Ser Ile Pro Asp Lys Gln Ile Thr Ala Ser Ser Ser Tyr Lys Thr 805 810 815 Trp Gly Leu His Leu Phe Ser Trp Asn Pro Ser Tyr Ala Arg Leu Asp 820 825 830 Lys Gln Gly Asn Phe Asn Ala Trp Val Ala Gly Ser Tyr Gly Asn Asp 835 840 845 Gln Trp Leu Gln Val Asp Leu Gly Ser Ser Lys Glu Val Thr Gly Ile 850 855 860 Ile Thr Gln Gly Ala Arg Asn Phe Gly Ser Val Gln Phe Val Ala Ser 865 870 875 880 Tyr Lys Val Ala Tyr Ser Asn Asp Ser Ala Asn Trp Thr Glu Tyr Gln 885 890 895 Asp Pro Arg Thr Gly Ser Ser Lys Ile Phe Pro Gly Asn Trp Asp Asn 900 905 910 His Ser His Lys Lys Asn Leu Phe Glu Thr Pro Ile Leu Ala Arg Tyr 915 920 925 Val Arg Ile Leu Pro Val Ala Trp His Asn Arg Ile Ala Leu Arg Leu 930 935 940 Glu Leu Leu Gly Cys 945 <210> 59 <211> 2847 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 59 ctggacatct gcagcaagaa tccttgccac aacggcggcc tgtgcgaaga gatttctcaa 60 gaagtgcggg gcgacgtttt ccccagctac acctgtacat gtctgaaggg ctacgccggc 120 aaccactgcg agacaaagga tgcccacaag agcgaggtgg cccacagatt caaggatctg 180 ggcgaagaga acttcaaggc cctggtgctg atcgccttcg ctcagtatct ccagcagagc 240 cctttcgagg accacgtgaa gctggtcaac gaagtgaccg agttcgccaa gacctgtgtg 300 gccgatgaga gcgccgagaa ctgtgataag agcctgcaca ccctgttcgg cgacaagctg 360 tgtacagtgg ccacactgag agaaacctac ggcgagatgg ccgactgctg tgccaagcaa 420 gagcccgaga gaaacgagtg cttcctgcag cacaaggacg acaaccccaa cctgcctaga 480 ctcgtgcgac ccgaagtgga tgtgatgtgc accgcctttc acgacaacga ggaaaccttc 540 ctgaagaagt acctgtacga gatcgccaga cggcacccct acttttatgc ccctgagctg 600 ctgttcttcg ccaagcggta taaggccgcc ttcaccgaat gttgccaggc cgctgataag 660 gctgcctgtc tgctgcctaa gctggacgag ctgagagatg agggcaaagc cagctctgcc 720 aagcagagac tgaagtgcgc cagcctgcag aagttcggcg agagagcttt taaggcctgg 780 gccgttgcca gactgagcca gagatttcct aaggccgagt ttgccgaggt gtccaagctc 840 gtgaccgatc tgacaaaggt gcacaccgag tgctgtcacg gcgatctgct ggaatgtgcc 900 gacgatagag ccgacctggc caagtacatc tgcgagaacc aggacagcat cagcagcaag 960 ctgaaagagt gctgcgagaa gcccctgctg gaaaagtctc actgtatcgc cgaggtggaa 1020 aacgacgaga tgcctgccga tctgcctagc ctggctgccg atttcgtgga aagcaaggac 1080 gtgtgcaaga actacgccga ggccaaggat gtgtttctgg gcatgtttct gtatgagtac 1140 gcccgcagac accccgacta ttctgtggtt ctgctgctgc ggctggccaa aacctacgag 1200 acaaccctgg aaaaatgctg cgccgctgcc gatcctcacg agtgttatgc caaggtgttc 1260 gacgagttca agcctctggt ggaagaaccc cagaacctga tcaagcagaa ctgcgagctg 1320 ttcgagcagc tgggcgagta caagttccag aatgccctgc tcgtgcggta caccaagaaa 1380 gtgcctcagg tgtccacacc tacactggtt gaggtgtccc ggaatctggg caaagtgggc 1440 agcaagtgtt gcaagcaccc tgaggccaag agaatgcctt gcgccgagga ttacctgagc 1500 gtggtgctga atcagctgtg cgtgctgcac gagaaaaccc ctgtgtccga cagagtgacc 1560 aagtgctgta ccgagagcct cgtgaacaga aggccttgct ttagcgccct ggaagtggac 1620 gagacatacg tgcccaaaga gttcaacgcc gagacattca ccttccacgc cgacatctgt 1680 accctgagcg agaaagagcg gcagatcaag aagcagacag ccctggtcga gctggttaag 1740 cacaagccca aggccaccaa agaacagctg aaggccgtga tggacgactt cgccgccttt 1800 gtcgagaagt gctgcaaggc cgacgacaaa gagacatgct tcgccgaaga gggcaagaaa 1860 ctggtggctg cttctcaggc tgccctggga ctgtgtgtgg aacccctcgg catggaaaac 1920 ggcaatatcg ccaatagcca gattgccgcc agcagcgtca gagtgacatt tctgggactg 1980 cagcactggg tgcccgagct ggctagactg aatagagccg gcatggtcaa cgcctggaca 2040 cccagcagca acgacgataa tccctggatc caagtgaacc tgctgcggcg tatgtgggtc 2100 acaggtgttg ttacacaggg cgcctctaga ctggccagcc acgagtatct gaaggccttt 2160 aaggtggcct acagcctgaa cggccacgag ttcgacttca tccacgacgt gaacaagaag 2220 cacaaagagt ttgtcggcaa ctggaacaag aacgccgtgc acgtgaacct gttcgagaca 2280 cctgtggaag cccagtacgt gcggctgtac cctacaagct gtcacaccgc ctgcactctg 2340 agattcgaac tgctgggatg cgagctgaac ggctgtgcta atcctctggg cctgaagaac 2400 aacagcatcc ccgataagca gatcaccgcc agctccagct ataagacatg gggcctgcac 2460 ctgttcagct ggaacccttc ttacgccaga ctggacaagc agggcaactt caatgcttgg 2520 gtggccggca gctacggcaa tgatcagtgg ctgcaagtgg acctgggcag cagcaaagaa 2580 gtgacaggca tcatcaccca gggcgccaga aatttcggca gcgtgcagtt tgtggccagc 2640 tacaaagtgg cctactccaa cgacagcgcc aactggaccg agtaccagga tcctagaacc 2700 ggcagctcca agatcttccc cggcaattgg gacaaccaca gccacaagaa gaatctgttc 2760 gaaaccccta tcctggccag atatgtgcgg attctgcccg tggcctggca caacagaatt 2820 gccctgagac tggaactgct cggctgt 2847 <210> 60 <400> 60 000 <210> 61 <400> 61 000 <210> 62 <211> 12 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Péptido Sintético" <400> 62 Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 1 5 10 <210> 63 <211> 8 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Péptido Sintético" <400> 63 Gly Ser Gly Ser Gly Ser Gly Ser 1 5 <210> 64 <211> 5 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Péptido Sintético" <400> 64 Gly Gly Gly Gly Ser 1 5 <210> 65 <211> 10 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Péptido Sintético" <400> 65 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 1 5 10 <210> 66 <211> 8 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Péptido Sintético" <400> 66 Gly Ser His His His His His His 1 5 <210> 67 <211> 6 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Etiqueta Sintética 6xHis" <400> 67 His His His His His His 1 5 <210> 68 <211> 463 <212> PRT <213> Mus musculus <400> 68 Met Gln Val Ser Arg Val Leu Ala Ala Leu Cys Gly Met Leu Leu Cys 1 5 10 15 Ala Ser Gly Leu Phe Ala Ala Ser Gly Asp Phe Cys Asp Ser Ser Leu 20 25 30 Cys Leu Asn Gly Gly Thr Cys Leu Thr Gly Gln Asp Asn Asp Ile Tyr 35 40 45 Cys Leu Cys Pro Glu Gly Phe Thr Gly Leu Val Cys Asn Glu Thr Glu 50 55 60 Arg Gly Pro Cys Ser Pro Asn Pro Cys Tyr Asn Asp Ala Lys Cys Leu 65 70 75 80 Val Thr Leu Asp Thr Gln Arg Gly Asp Ile Phe Thr Glu Tyr Ile Cys 85 90 95 Gln Cys Pro Val Gly Tyr Ser Gly Ile His Cys Glu Thr Glu Thr Asn 100 105 110 Tyr Tyr Asn Leu Asp Gly Glu Tyr Met Phe Thr Thr Ala Val Pro Asn 115 120 125 Thr Ala Val Pro Thr Pro Ala Pro Thr Pro Asp Leu Ser Asn Asn Leu 130 135 140 Ala Ser Arg Cys Ser Thr Gln Leu Gly Met Glu Gly Gly Ala Ile Ala 145 150 155 160 Asp Ser Gln Ile Ser Ala Ser Ser Val Tyr Met Gly Phe Met Gly Leu 165 170 175 Gln Arg Trp Gly Pro Glu Leu Ala Arg Leu Tyr Arg Thr Gly Ile Val 180 185 190 Asn Ala Trp Thr Ala Ser Asn Tyr Asp Ser Lys Pro Trp Ile Gln Val 195 200 205 Asn Leu Leu Arg Lys Met Arg Val Ser Gly Val Met Thr Gln Gly Ala 210 215 220 Ser Arg Ala Gly Arg Ala Glu Tyr Leu Lys Thr Phe Lys Val Ala Tyr 225 230 235 240 Ser Leu Asp Gly Arg Lys Phe Glu Phe Ile Gln Asp Glu Ser Gly Gly 245 250 255 Asp Lys Glu Phe Leu Gly Asn Leu Asp Asn Asn Ser Leu Lys Val Asn 260 265 270 Met Phe Asn Pro Thr Leu Glu Ala Gln Tyr Ile Lys Leu Tyr Pro Val 275 280 285 Ser Cys His Arg Gly Cys Thr Leu Arg Phe Glu Leu Leu Gly Cys Glu 290 295 300 Leu His Gly Cys Ser Glu Pro Leu Gly Leu Lys Asn Asn Thr Ile Pro 305 310 315 320 Asp Ser Gln Met Ser Ala Ser Ser Ser Tyr Lys Thr Trp Asn Leu Arg 325 330 335 Ala Phe Gly Trp Tyr Pro His Leu Gly Arg Leu Asp Asn Gln Gly Lys 340 345 350 Ile Asn Ala Trp Thr Ala Gln Ser Asn Ser Ala Lys Glu Trp Leu Gln 355 360 365 Val Asp Leu Gly Thr Gln Arg Gln Val Thr Gly Ile Ile Thr Gln Gly 370 375 380 Ala Arg Asp Phe Gly His Ile Gln Tyr Val Ala Ser Tyr Lys Val Ala 385 390 395 400 His Ser Asp Asp Gly Val Gln Trp Thr Val Tyr Glu Glu Gln Gly Ser 405 410 415 Ser Lys Val Phe Gln Gly Asn Leu Asp Asn Asn Ser His Lys Lys Asn 420 425 430 Ile Phe Glu Lys Pro Phe Met Ala Arg Tyr Val Arg Val Leu Pro Val 435 440 445 Ser Trp His Asn Arg Ile Thr Leu Arg Leu Glu Leu Leu Gly Cys 450 455 460 <210> 69 <211> 1030 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 69 Asp Ile Cys Asp Pro Asn Pro Cys Glu Asn Gly Gly Ile Cys Leu Pro 1 5 10 15 Gly Leu Ala Asp Gly Ser Phe Ser Cys Glu Cys Pro Asp Gly Phe Thr 20 25 30 Asp Pro Asn Cys Ser Ser Val Val Glu Val Ala Ser Asp Glu Glu Glu 35 40 45 Pro Thr Ser Ala Gly Pro Cys Thr Pro Asn Pro Cys His Asn Gly Gly 50 55 60 Thr Cys Glu Ile Ser Glu Ala Tyr Arg Gly Asp Thr Phe Ile Gly Tyr 65 70 75 80 Val Cys Lys Cys Pro Arg Gly Phe Asn Gly Ile His Cys Gln His Asn 85 90 95 Ile Asn Glu Cys Glu Val Glu Pro Cys Lys Asn Gly Gly Ile Cys Thr 100 105 110 Asp Leu Val Ala Asn Tyr Ser Cys Glu Cys Pro Gly Glu Phe Met Gly 115 120 125 Arg Asn Cys Gln Tyr Lys Asp Ala His Lys Ser Glu Val Ala His Arg 130 135 140 Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala 145 150 155 160 Phe Ala Gln Tyr Leu Gln Gln Ser Pro Phe Glu Asp His Val Lys Leu 165 170 175 Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser 180 185 190 Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu 195 200 205 Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys 210 215 220 Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys 225 230 235 240 Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val 245 250 255 Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr 260 265 270 Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu 275 280 285 Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln 290 295 300 Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg 305 310 315 320 Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser 325 330 335 Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg 340 345 350 Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu 355 360 365 Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu 370 375 380 Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu 385 390 395 400 Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro 405 410 415 Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met 420 425 430 Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp 435 440 445 Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe 450 455 460 Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu 465 470 475 480 Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala 485 490 495 Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys 500 505 510 Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu 515 520 525 Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg 530 535 540 Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val 545 550 555 560 Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu 565 570 575 Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn 580 585 590 Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr 595 600 605 Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala 610 615 620 Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr 625 630 635 640 Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln 645 650 655 Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys 660 665 670 Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe 675 680 685 Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu 690 695 700 Glu Gly Lys Lys Leu Val Ala Cys Ser Gly Pro Leu Gly Ile Glu Gly 705 710 715 720 Gly Ile Ile Ser Asn Gln Gln Ile Thr Ala Ser Ser Thr His Arg Ala 725 730 735 Leu Phe Gly Leu Gln Lys Trp Tyr Pro Tyr Tyr Ala Arg Leu Asn Lys 740 745 750 Lys Gly Leu Ile Asn Ala Trp Thr Ala Ala Glu Asn Asp Arg Trp Pro 755 760 765 Trp Ile Gln Ile Asn Leu Gln Arg Lys Met Arg Val Thr Gly Val Ile 770 775 780 Thr Gln Gly Ala Lys Arg Ile Gly Ser Pro Glu Tyr Ile Lys Ser Tyr 785 790 795 800 Lys Ile Ala Tyr Ser Asn Asp Gly Lys Thr Trp Ala Met Tyr Lys Val 805 810 815 Lys Gly Thr Asn Glu Asp Met Val Phe Arg Gly Asn Ile Asp Asn Asn 820 825 830 Thr Pro Tyr Ala Asn Ser Phe Thr Pro Pro Ile Lys Ala Gln Tyr Val 835 840 845 Arg Leu Tyr Pro Gln Val Cys Arg Arg His Cys Thr Leu Arg Met Glu 850 855 860 Leu Leu Gly Cys Glu Leu Ser Gly Cys Ser Glu Pro Leu Gly Met Lys 865 870 875 880 Ser Gly His Ile Gln Asp Tyr Gln Ile Thr Ala Ser Ser Ile Phe Arg 885 890 895 Thr Leu Asn Met Asp Met Phe Thr Trp Glu Pro Arg Lys Ala Arg Leu 900 905 910 Asp Lys Gln Gly Lys Val Asn Ala Trp Thr Ser Gly His Asn Asp Gln 915 920 925 Ser Gln Trp Leu Gln Val Asp Leu Leu Val Pro Thr Lys Val Thr Gly 930 935 940 Ile Ile Thr Gln Gly Ala Lys Asp Phe Gly His Val Gln Phe Val Gly 945 950 955 960 Ser Tyr Lys Leu Ala Tyr Ser Asn Asp Gly Glu His Trp Thr Val Tyr 965 970 975 Gln Asp Glu Lys Gln Arg Lys Asp Lys Val Phe Gln Gly Asn Phe Asp 980 985 990 Asn Asp Thr His Arg Lys Asn Val Ile Asp Pro Pro Ile Tyr Ala Arg 995 1000 1005 His Ile Arg Ile Leu Pro Trp Ser Trp Tyr Gly Arg Ile Thr Leu 1010 1015 1020 Arg Ser Glu Leu Leu Gly Cys 1025 1030 <210> 70 <211> 1036 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 70 Asp Ile Cys Asp Pro Asn Pro Cys Glu Asn Gly Gly Ile Cys Leu Pro 1 5 10 15 Gly Leu Ala Asp Gly Ser Phe Ser Cys Glu Cys Pro Asp Gly Phe Thr 20 25 30 Asp Pro Asn Cys Ser Ser Val Val Glu Val Ala Ser Asp Glu Glu Glu 35 40 45 Pro Thr Ser Ala Gly Pro Cys Thr Pro Asn Pro Cys His Asn Gly Gly 50 55 60 Thr Cys Glu Ile Ser Glu Ala Tyr Arg Gly Asp Thr Phe Ile Gly Tyr 65 70 75 80 Val Cys Lys Cys Pro Arg Gly Phe Asn Gly Ile His Cys Gln His Asn 85 90 95 Ile Asn Glu Cys Glu Val Glu Pro Cys Lys Asn Gly Gly Ile Cys Thr 100 105 110 Asp Leu Val Ala Asn Tyr Ser Cys Glu Cys Pro Gly Glu Phe Met Gly 115 120 125 Arg Asn Cys Gln Tyr Lys Asp Ala His Lys Ser Glu Val Ala His Arg 130 135 140 Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala 145 150 155 160 Phe Ala Gln Tyr Leu Gln Gln Ser Pro Phe Glu Asp His Val Lys Leu 165 170 175 Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser 180 185 190 Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu 195 200 205 Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys 210 215 220 Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys 225 230 235 240 Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val 245 250 255 Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr 260 265 270 Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu 275 280 285 Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln 290 295 300 Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg 305 310 315 320 Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser 325 330 335 Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg 340 345 350 Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu 355 360 365 Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu 370 375 380 Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu 385 390 395 400 Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro 405 410 415 Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met 420 425 430 Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp 435 440 445 Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe 450 455 460 Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu 465 470 475 480 Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala 485 490 495 Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys 500 505 510 Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu 515 520 525 Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg 530 535 540 Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val 545 550 555 560 Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu 565 570 575 Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn 580 585 590 Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr 595 600 605 Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala 610 615 620 Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr 625 630 635 640 Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln 645 650 655 Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys 660 665 670 Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe 675 680 685 Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu 690 695 700 Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Cys Ser Gly 705 710 715 720 Pro Leu Gly Ile Glu Gly Gly Ile Ile Ser Asn Gln Gln Ile Thr Ala 725 730 735 Ser Ser Thr His Arg Ala Leu Phe Gly Leu Gln Lys Trp Tyr Pro Tyr 740 745 750 Tyr Ala Arg Leu Asn Lys Lys Gly Leu Ile Asn Ala Trp Thr Ala Ala 755 760 765 Glu Asn Asp Arg Trp Pro Trp Ile Gln Ile Asn Leu Gln Arg Lys Met 770 775 780 Arg Val Thr Gly Val Ile Thr Gln Gly Ala Lys Arg Ile Gly Ser Pro 785 790 795 800 Glu Tyr Ile Lys Ser Tyr Lys Ile Ala Tyr Ser Asn Asp Gly Lys Thr 805 810 815 Trp Ala Met Tyr Lys Val Lys Gly Thr Asn Glu Asp Met Val Phe Arg 820 825 830 Gly Asn Ile Asp Asn Asn Thr Pro Tyr Ala Asn Ser Phe Thr Pro Pro 835 840 845 Ile Lys Ala Gln Tyr Val Arg Leu Tyr Pro Gln Val Cys Arg Arg His 850 855 860 Cys Thr Leu Arg Met Glu Leu Leu Gly Cys Glu Leu Ser Gly Cys Ser 865 870 875 880 Glu Pro Leu Gly Met Lys Ser Gly His Ile Gln Asp Tyr Gln Ile Thr 885 890 895 Ala Ser Ser Ile Phe Arg Thr Leu Asn Met Asp Met Phe Thr Trp Glu 900 905 910 Pro Arg Lys Ala Arg Leu Asp Lys Gln Gly Lys Val Asn Ala Trp Thr 915 920 925 Ser Gly His Asn Asp Gln Ser Gln Trp Leu Gln Val Asp Leu Leu Val 930 935 940 Pro Thr Lys Val Thr Gly Ile Ile Thr Gln Gly Ala Lys Asp Phe Gly 945 950 955 960 His Val Gln Phe Val Gly Ser Tyr Lys Leu Ala Tyr Ser Asn Asp Gly 965 970 975 Glu His Trp Thr Val Tyr Gln Asp Glu Lys Gln Arg Lys Asp Lys Val 980 985 990 Phe Gln Gly Asn Phe Asp Asn Asp Thr His Arg Lys Asn Val Ile Asp 995 1000 1005 Pro Pro Ile Tyr Ala Arg His Ile Arg Ile Leu Pro Trp Ser Trp 1010 1015 1020 Tyr Gly Arg Ile Thr Leu Arg Ser Glu Leu Leu Gly Cys 1025 1030 1035 <210> 71 <211> 872 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 71 Asp Ile Cys Asp Pro Asn Pro Cys Glu Asn Gly Gly Ile Cys Leu Pro 1 5 10 15 Gly Leu Ala Asp Gly Ser Phe Ser Cys Glu Cys Pro Asp Gly Phe Thr 20 25 30 Asp Pro Asn Cys Ser Ser Val Val Glu Val Ala Ser Asp Glu Glu Glu 35 40 45 Pro Thr Ser Ala Gly Pro Cys Thr Pro Asn Pro Cys His Asn Gly Gly 50 55 60 Thr Cys Glu Ile Ser Glu Ala Tyr Arg Gly Asp Thr Phe Ile Gly Tyr 65 70 75 80 Val Cys Lys Cys Pro Arg Gly Phe Asn Gly Ile His Cys Gln His Asn 85 90 95 Ile Asn Glu Cys Glu Val Glu Pro Cys Lys Asn Gly Gly Ile Cys Thr 100 105 110 Asp Leu Val Ala Asn Tyr Ser Cys Glu Cys Pro Gly Glu Phe Met Gly 115 120 125 Arg Asn Cys Gln Tyr Lys Asp Ala His Lys Ser Glu Val Ala His Arg 130 135 140 Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala 145 150 155 160 Phe Ala Gln Tyr Leu Gln Gln Ser Pro Phe Glu Asp His Val Lys Leu 165 170 175 Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser 180 185 190 Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu 195 200 205 Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys 210 215 220 Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys 225 230 235 240 Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val 245 250 255 Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr 260 265 270 Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu 275 280 285 Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln 290 295 300 Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg 305 310 315 320 Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser 325 330 335 Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg 340 345 350 Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu 355 360 365 Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu 370 375 380 Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu 385 390 395 400 Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro 405 410 415 Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met 420 425 430 Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp 435 440 445 Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe 450 455 460 Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu 465 470 475 480 Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala 485 490 495 Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys 500 505 510 Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu 515 520 525 Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg 530 535 540 Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val 545 550 555 560 Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu 565 570 575 Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn 580 585 590 Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr 595 600 605 Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala 610 615 620 Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr 625 630 635 640 Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln 645 650 655 Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys 660 665 670 Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe 675 680 685 Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu 690 695 700 Glu Gly Lys Lys Leu Val Ala Cys Ser Gly Pro Leu Gly Ile Glu Gly 705 710 715 720 Gly Ile Ile Ser Asn Gln Gln Ile Thr Ala Ser Ser Thr His Arg Ala 725 730 735 Leu Phe Gly Leu Gln Lys Trp Tyr Pro Tyr Tyr Ala Arg Leu Asn Lys 740 745 750 Lys Gly Leu Ile Asn Ala Trp Thr Ala Ala Glu Asn Asp Arg Trp Pro 755 760 765 Trp Ile Gln Ile Asn Leu Gln Arg Lys Met Arg Val Thr Gly Val Ile 770 775 780 Thr Gln Gly Ala Lys Arg Ile Gly Ser Pro Glu Tyr Ile Lys Ser Tyr 785 790 795 800 Lys Ile Ala Tyr Ser Asn Asp Gly Lys Thr Trp Ala Met Tyr Lys Val 805 810 815 Lys Gly Thr Asn Glu Asp Met Val Phe Arg Gly Asn Ile Asp Asn Asn 820 825 830 Thr Pro Tyr Ala Asn Ser Phe Thr Pro Pro Ile Lys Ala Gln Tyr Val 835 840 845 Arg Leu Tyr Pro Gln Val Cys Arg Arg His Cys Thr Leu Arg Met Glu 850 855 860 Leu Leu Gly Cys Glu Leu Ser Gly 865 870 <210> 72 <211> 878 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 72 Asp Ile Cys Asp Pro Asn Pro Cys Glu Asn Gly Gly Ile Cys Leu Pro 1 5 10 15 Gly Leu Ala Asp Gly Ser Phe Ser Cys Glu Cys Pro Asp Gly Phe Thr 20 25 30 Asp Pro Asn Cys Ser Ser Val Val Glu Val Ala Ser Asp Glu Glu Glu 35 40 45 Pro Thr Ser Ala Gly Pro Cys Thr Pro Asn Pro Cys His Asn Gly Gly 50 55 60 Thr Cys Glu Ile Ser Glu Ala Tyr Arg Gly Asp Thr Phe Ile Gly Tyr 65 70 75 80 Val Cys Lys Cys Pro Arg Gly Phe Asn Gly Ile His Cys Gln His Asn 85 90 95 Ile Asn Glu Cys Glu Val Glu Pro Cys Lys Asn Gly Gly Ile Cys Thr 100 105 110 Asp Leu Val Ala Asn Tyr Ser Cys Glu Cys Pro Gly Glu Phe Met Gly 115 120 125 Arg Asn Cys Gln Tyr Lys Asp Ala His Lys Ser Glu Val Ala His Arg 130 135 140 Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala 145 150 155 160 Phe Ala Gln Tyr Leu Gln Gln Ser Pro Phe Glu Asp His Val Lys Leu 165 170 175 Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser 180 185 190 Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu 195 200 205 Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys 210 215 220 Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys 225 230 235 240 Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val 245 250 255 Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr 260 265 270 Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu 275 280 285 Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln 290 295 300 Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg 305 310 315 320 Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser 325 330 335 Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg 340 345 350 Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu 355 360 365 Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu 370 375 380 Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu 385 390 395 400 Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro 405 410 415 Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met 420 425 430 Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp 435 440 445 Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe 450 455 460 Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu 465 470 475 480 Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala 485 490 495 Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys 500 505 510 Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu 515 520 525 Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg 530 535 540 Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val 545 550 555 560 Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu 565 570 575 Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn 580 585 590 Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr 595 600 605 Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala 610 615 620 Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr 625 630 635 640 Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln 645 650 655 Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys 660 665 670 Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe 675 680 685 Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu 690 695 700 Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Cys Ser Gly 705 710 715 720 Pro Leu Gly Ile Glu Gly Gly Ile Ile Ser Asn Gln Gln Ile Thr Ala 725 730 735 Ser Ser Thr His Arg Ala Leu Phe Gly Leu Gln Lys Trp Tyr Pro Tyr 740 745 750 Tyr Ala Arg Leu Asn Lys Lys Gly Leu Ile Asn Ala Trp Thr Ala Ala 755 760 765 Glu Asn Asp Arg Trp Pro Trp Ile Gln Ile Asn Leu Gln Arg Lys Met 770 775 780 Arg Val Thr Gly Val Ile Thr Gln Gly Ala Lys Arg Ile Gly Ser Pro 785 790 795 800 Glu Tyr Ile Lys Ser Tyr Lys Ile Ala Tyr Ser Asn Asp Gly Lys Thr 805 810 815 Trp Ala Met Tyr Lys Val Lys Gly Thr Asn Glu Asp Met Val Phe Arg 820 825 830 Gly Asn Ile Asp Asn Asn Thr Pro Tyr Ala Asn Ser Phe Thr Pro Pro 835 840 845 Ile Lys Ala Gln Tyr Val Arg Leu Tyr Pro Gln Val Cys Arg Arg His 850 855 860 Cys Thr Leu Arg Met Glu Leu Leu Gly Cys Glu Leu Ser Gly 865 870 875 <210> 73 <211> 783 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 73 Leu Asp Ile Cys Ser Lys Asn Pro Cys His Asn Gly Gly Leu Cys Glu 1 5 10 15 Glu Ile Ser Gln Glu Val Arg Gly Asp Val Phe Pro Ser Tyr Thr Cys 20 25 30 Thr Cys Leu Lys Gly Tyr Ala Gly Asn His Cys Glu Thr Lys Asp Ala 35 40 45 His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn 50 55 60 Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Ser 65 70 75 80 Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala 85 90 95 Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu 100 105 110 His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu 115 120 125 Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg 130 135 140 Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg 145 150 155 160 Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn 165 170 175 Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His 180 185 190 Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys 195 200 205 Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu 210 215 220 Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala 225 230 235 240 Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala 245 250 255 Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala 260 265 270 Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His 275 280 285 Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala 290 295 300 Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys 305 310 315 320 Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile 325 330 335 Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala 340 345 350 Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala 355 360 365 Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His 370 375 380 Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu 385 390 395 400 Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr 405 410 415 Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn 420 425 430 Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys 435 440 445 Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val 450 455 460 Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly 465 470 475 480 Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu 485 490 495 Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys 500 505 510 Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val 515 520 525 Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val 530 535 540 Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys 545 550 555 560 Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val 565 570 575 Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala 580 585 590 Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp 595 600 605 Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Cys 610 615 620 Val Glu Pro Leu Gly Met Glu Asn Gly Asn Ile Ala Asn Ser Gln Ile 625 630 635 640 Ala Ala Ser Ser Val Arg Val Thr Phe Leu Gly Leu Gln His Trp Val 645 650 655 Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly Met Val Asn Ala Trp Thr 660 665 670 Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile Gln Val Asn Leu Leu Arg 675 680 685 Arg Met Trp Val Thr Gly Val Val Thr Gln Gly Ala Ser Arg Leu Ala 690 695 700 Ser His Glu Tyr Leu Lys Ala Phe Lys Val Ala Tyr Ser Leu Asn Gly 705 710 715 720 His Glu Phe Asp Phe Ile His Asp Val Asn Lys Lys His Lys Glu Phe 725 730 735 Val Gly Asn Trp Asn Lys Asn Ala Val His Val Asn Leu Phe Glu Thr 740 745 750 Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr Pro Thr Ser Cys His Thr 755 760 765 Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly Cys Glu Leu Asn Gly 770 775 780 <210> 74 <211> 789 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 74 Leu Asp Ile Cys Ser Lys Asn Pro Cys His Asn Gly Gly Leu Cys Glu 1 5 10 15 Glu Ile Ser Gln Glu Val Arg Gly Asp Val Phe Pro Ser Tyr Thr Cys 20 25 30 Thr Cys Leu Lys Gly Tyr Ala Gly Asn His Cys Glu Thr Lys Asp Ala 35 40 45 His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn 50 55 60 Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Ser 65 70 75 80 Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala 85 90 95 Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu 100 105 110 His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu 115 120 125 Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg 130 135 140 Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg 145 150 155 160 Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn 165 170 175 Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His 180 185 190 Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys 195 200 205 Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu 210 215 220 Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala 225 230 235 240 Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala 245 250 255 Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala 260 265 270 Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His 275 280 285 Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala 290 295 300 Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys 305 310 315 320 Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile 325 330 335 Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala 340 345 350 Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala 355 360 365 Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His 370 375 380 Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu 385 390 395 400 Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr 405 410 415 Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn 420 425 430 Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys 435 440 445 Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val 450 455 460 Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly 465 470 475 480 Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu 485 490 495 Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys 500 505 510 Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val 515 520 525 Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val 530 535 540 Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys 545 550 555 560 Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val 565 570 575 Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala 580 585 590 Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp 595 600 605 Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala 610 615 620 Ser Gln Ala Ala Leu Cys Val Glu Pro Leu Gly Met Glu Asn Gly Asn 625 630 635 640 Ile Ala Asn Ser Gln Ile Ala Ala Ser Ser Val Arg Val Thr Phe Leu 645 650 655 Gly Leu Gln His Trp Val Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly 660 665 670 Met Val Asn Ala Trp Thr Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile 675 680 685 Gln Val Asn Leu Leu Arg Arg Met Trp Val Thr Gly Val Val Thr Gln 690 695 700 Gly Ala Ser Arg Leu Ala Ser His Glu Tyr Leu Lys Ala Phe Lys Val 705 710 715 720 Ala Tyr Ser Leu Asn Gly His Glu Phe Asp Phe Ile His Asp Val Asn 725 730 735 Lys Lys His Lys Glu Phe Val Gly Asn Trp Asn Lys Asn Ala Val His 740 745 750 Val Asn Leu Phe Glu Thr Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr 755 760 765 Pro Thr Ser Cys His Thr Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly 770 775 780 Cys Glu Leu Asn Gly 785 <210> 75 <211> 387 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 75 Met Pro Arg Pro Arg Leu Leu Ala Ala Leu Cys Gly Ala Leu Leu Cys 1 5 10 15 Ala Pro Ser Leu Leu Val Ala Leu Asp Ile Cys Ser Lys Asn Pro Cys 20 25 30 His Asn Gly Gly Leu Cys Glu Glu Ile Ser Gln Glu Val Arg Gly Asp 35 40 45 Val Phe Pro Ser Tyr Thr Cys Thr Cys Leu Lys Gly Tyr Ala Gly Asn 50 55 60 His Cys Glu Thr Lys Cys Val Glu Pro Leu Gly Met Glu Asn Gly Asn 65 70 75 80 Ile Ala Asn Ser Gln Ile Ala Ala Ser Ser Val Arg Val Thr Phe Leu 85 90 95 Gly Leu Gln His Trp Val Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly 100 105 110 Met Val Asn Ala Trp Thr Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile 115 120 125 Gln Val Asn Leu Leu Arg Arg Met Trp Val Thr Gly Val Val Thr Gln 130 135 140 Gly Ala Ser Arg Leu Ala Ser His Glu Tyr Leu Lys Ala Phe Lys Val 145 150 155 160 Ala Tyr Ser Leu Asn Gly His Glu Phe Asp Phe Ile His Asp Val Asn 165 170 175 Lys Lys His Lys Glu Phe Val Gly Asn Trp Asn Lys Asn Ala Val His 180 185 190 Val Asn Leu Phe Glu Thr Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr 195 200 205 Pro Thr Ser Cys His Thr Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly 210 215 220 Cys Glu Leu Asn Gly Cys Ala Asn Pro Leu Gly Leu Lys Asn Asn Ser 225 230 235 240 Ile Pro Asp Lys Gln Ile Thr Ala Ser Ser Ser Tyr Lys Thr Trp Gly 245 250 255 Leu His Leu Phe Ser Trp Asn Pro Ser Tyr Ala Arg Leu Asp Lys Gln 260 265 270 Gly Asn Phe Asn Ala Trp Val Ala Gly Ser Tyr Gly Asn Asp Gln Trp 275 280 285 Leu Gln Val Asp Leu Gly Ser Ser Lys Glu Val Thr Gly Ile Ile Thr 290 295 300 Gln Gly Ala Arg Asn Phe Gly Ser Val Gln Phe Val Ala Ser Tyr Lys 305 310 315 320 Val Ala Tyr Ser Asn Asp Ser Ala Asn Trp Thr Glu Tyr Gln Asp Pro 325 330 335 Arg Thr Gly Ser Ser Lys Ile Phe Pro Gly Asn Trp Asp Asn His Ser 340 345 350 His Lys Lys Asn Leu Phe Glu Thr Pro Ile Leu Ala Arg Tyr Val Arg 355 360 365 Ile Leu Pro Val Ala Trp His Asn Arg Ile Ala Leu Arg Leu Glu Leu 370 375 380 Leu Gly Cys 385 <210> 76 <211> 318 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 76 Cys Val Glu Pro Leu Gly Met Glu Asn Gly Asn Ile Ala Asn Ser Gln 1 5 10 15 Ile Ala Ala Ser Ser Val Arg Val Thr Phe Leu Gly Leu Gln His Trp 20 25 30 Val Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly Met Val Asn Ala Trp 35 40 45 Thr Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile Gln Val Asn Leu Leu 50 55 60 Arg Arg Met Trp Val Thr Gly Val Val Thr Gln Gly Ala Ser Arg Leu 65 70 75 80 Ala Ser His Glu Tyr Leu Lys Ala Phe Lys Val Ala Tyr Ser Leu Asn 85 90 95 Gly His Glu Phe Asp Phe Ile His Asp Val Asn Lys Lys His Lys Glu 100 105 110 Phe Val Gly Asn Trp Asn Lys Asn Ala Val His Val Asn Leu Phe Glu 115 120 125 Thr Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr Pro Thr Ser Cys His 130 135 140 Thr Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly Cys Glu Leu Asn Gly 145 150 155 160 Cys Ala Asn Pro Leu Gly Leu Lys Asn Asn Ser Ile Pro Asp Lys Gln 165 170 175 Ile Thr Ala Ser Ser Ser Tyr Lys Thr Trp Gly Leu His Leu Phe Ser 180 185 190 Trp Asn Pro Ser Tyr Ala Arg Leu Asp Lys Gln Gly Asn Phe Asn Ala 195 200 205 Trp Val Ala Gly Ser Tyr Gly Asn Asp Gln Trp Leu Gln Val Asp Leu 210 215 220 Gly Ser Ser Lys Glu Val Thr Gly Ile Ile Thr Gln Gly Ala Arg Asn 225 230 235 240 Phe Gly Ser Val Gln Phe Val Ala Ser Tyr Lys Val Ala Tyr Ser Asn 245 250 255 Asp Ser Ala Asn Trp Thr Glu Tyr Gln Asp Pro Arg Thr Gly Ser Ser 260 265 270 Lys Ile Phe Pro Gly Asn Trp Asp Asn His Ser His Lys Lys Asn Leu 275 280 285 Phe Glu Thr Pro Ile Leu Ala Arg Tyr Val Arg Ile Leu Pro Val Ala 290 295 300 Trp His Asn Arg Ile Ala Leu Arg Leu Glu Leu Leu Gly Cys 305 310 315 <210> 77 <211> 134 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 77 Asp Ile Cys Asp Pro Asn Pro Cys Glu Asn Gly Gly Ile Cys Leu Pro 1 5 10 15 Gly Leu Ala Asp Gly Ser Phe Ser Cys Glu Cys Pro Asp Gly Phe Thr 20 25 30 Asp Pro Asn Cys Ser Ser Val Val Glu Val Ala Ser Asp Glu Glu Glu 35 40 45 Pro Thr Ser Ala Gly Pro Cys Thr Pro Asn Pro Cys His Asn Gly Gly 50 55 60 Thr Cys Glu Ile Ser Glu Ala Tyr Arg Gly Asp Thr Phe Ile Gly Tyr 65 70 75 80 Val Cys Lys Cys Pro Arg Gly Phe Asn Gly Ile His Cys Gln His Asn 85 90 95 Ile Asn Glu Cys Glu Val Glu Pro Cys Lys Asn Gly Gly Ile Cys Thr 100 105 110 Asp Leu Val Ala Asn Tyr Ser Cys Glu Cys Pro Gly Glu Phe Met Gly 115 120 125 Arg Asn Cys Gln Tyr Lys 130 <210> 78 <211> 323 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 78 Cys Ser Gly Pro Leu Gly Ile Glu Gly Gly Ile Ile Ser Asn Gln Gln 1 5 10 15 Ile Thr Ala Ser Ser Thr His Arg Ala Leu Phe Gly Leu Gln Lys Trp 20 25 30 Tyr Pro Tyr Tyr Ala Arg Leu Asn Lys Lys Gly Leu Ile Asn Ala Trp 35 40 45 Thr Ala Ala Glu Asn Asp Arg Trp Pro Trp Ile Gln Ile Asn Leu Gln 50 55 60 Arg Lys Met Arg Val Thr Gly Val Ile Thr Gln Gly Ala Lys Arg Ile 65 70 75 80 Gly Ser Pro Glu Tyr Ile Lys Ser Tyr Lys Ile Ala Tyr Ser Asn Asp 85 90 95 Gly Lys Thr Trp Ala Met Tyr Lys Val Lys Gly Thr Asn Glu Asp Met 100 105 110 Val Phe Arg Gly Asn Ile Asp Asn Asn Thr Pro Tyr Ala Asn Ser Phe 115 120 125 Thr Pro Pro Ile Lys Ala Gln Tyr Val Arg Leu Tyr Pro Gln Val Cys 130 135 140 Arg Arg His Cys Thr Leu Arg Met Glu Leu Leu Gly Cys Glu Leu Ser 145 150 155 160 Gly Cys Ser Glu Pro Leu Gly Met Lys Ser Gly His Ile Gln Asp Tyr 165 170 175 Gln Ile Thr Ala Ser Ser Ile Phe Arg Thr Leu Asn Met Asp Met Phe 180 185 190 Thr Trp Glu Pro Arg Lys Ala Arg Leu Asp Lys Gln Gly Lys Val Asn 195 200 205 Ala Trp Thr Ser Gly His Asn Asp Gln Ser Gln Trp Leu Gln Val Asp 210 215 220 Leu Leu Val Pro Thr Lys Val Thr Gly Ile Ile Thr Gln Gly Ala Lys 225 230 235 240 Asp Phe Gly His Val Gln Phe Val Gly Ser Tyr Lys Leu Ala Tyr Ser 245 250 255 Asn Asp Gly Glu His Trp Thr Val Tyr Gln Asp Glu Lys Gln Arg Lys 260 265 270 Asp Lys Val Phe Gln Gly Asn Phe Asp Asn Asp Thr His Arg Lys Asn 275 280 285 Val Ile Asp Pro Pro Ile Tyr Ala Arg His Ile Arg Ile Leu Pro Trp 290 295 300 Ser Trp Tyr Gly Arg Ile Thr Leu Arg Ser Glu Leu Leu Gly Cys Thr 305 310 315 320 Glu Glu Glu <210> 79 <211> 319 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 79 Cys Ser Gly Pro Leu Gly Ile Glu Gly Gly Ile Ile Ser Asn Gln Gln 1 5 10 15 Ile Thr Ala Ser Ser Thr His Arg Ala Leu Phe Gly Leu Gln Lys Trp 20 25 30 Tyr Pro Tyr Tyr Ala Arg Leu Asn Lys Lys Gly Leu Ile Asn Ala Trp 35 40 45 Thr Ala Ala Glu Asn Asp Arg Trp Pro Trp Ile Gln Ile Asn Leu Gln 50 55 60 Arg Lys Met Arg Val Thr Gly Val Ile Thr Gln Gly Ala Lys Arg Ile 65 70 75 80 Gly Ser Pro Glu Tyr Ile Lys Ser Tyr Lys Ile Ala Tyr Ser Asn Asp 85 90 95 Gly Lys Thr Trp Ala Met Tyr Lys Val Lys Gly Thr Asn Glu Asp Met 100 105 110 Val Phe Arg Gly Asn Ile Asp Asn Asn Thr Pro Tyr Ala Asn Ser Phe 115 120 125 Thr Pro Pro Ile Lys Ala Gln Tyr Val Arg Leu Tyr Pro Gln Val Cys 130 135 140 Arg Arg His Cys Thr Leu Arg Met Glu Leu Leu Gly Cys Glu Leu Ser 145 150 155 160 Gly Cys Ser Glu Pro Leu Gly Met Lys Ser Gly His Ile Gln Asp Tyr 165 170 175 Gln Ile Thr Ala Ser Ser Ile Phe Arg Thr Leu Asn Met Asp Met Phe 180 185 190 Thr Trp Glu Pro Arg Lys Ala Arg Leu Asp Lys Gln Gly Lys Val Asn 195 200 205 Ala Trp Thr Ser Gly His Asn Asp Gln Ser Gln Trp Leu Gln Val Asp 210 215 220 Leu Leu Val Pro Thr Lys Val Thr Gly Ile Ile Thr Gln Gly Ala Lys 225 230 235 240 Asp Phe Gly His Val Gln Phe Val Gly Ser Tyr Lys Leu Ala Tyr Ser 245 250 255 Asn Asp Gly Glu His Trp Thr Val Tyr Gln Asp Glu Lys Gln Arg Lys 260 265 270 Asp Lys Val Phe Gln Gly Asn Phe Asp Asn Asp Thr His Arg Lys Asn 275 280 285 Val Ile Asp Pro Pro Ile Tyr Ala Arg His Ile Arg Ile Leu Pro Trp 290 295 300 Ser Trp Tyr Gly Arg Ile Thr Leu Arg Ser Glu Leu Leu Gly Cys 305 310 315 <210> 80 <211> 1029 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 80 Asp Ile Cys Asp Pro Asn Pro Cys Glu Asn Gly Gly Ile Cys Leu Pro 1 5 10 15 Gly Leu Ala Asp Gly Ser Phe Ser Cys Glu Cys Pro Asp Gly Phe Thr 20 25 30 Asp Pro Asn Cys Ser Ser Val Val Glu Val Ala Ser Asp Glu Glu Glu 35 40 45 Pro Thr Ser Ala Gly Pro Cys Thr Pro Asn Pro Cys His Asn Gly Gly 50 55 60 Thr Cys Glu Ile Ser Glu Ala Tyr Arg Gly Asp Thr Phe Ile Gly Tyr 65 70 75 80 Val Cys Lys Cys Pro Arg Gly Phe Asn Gly Ile His Cys Gln His Asn 85 90 95 Ile Asn Glu Cys Glu Val Glu Pro Cys Lys Asn Gly Gly Ile Cys Thr 100 105 110 Asp Leu Val Ala Asn Tyr Ser Cys Glu Cys Pro Gly Glu Phe Met Gly 115 120 125 Arg Asn Cys Gln Tyr Lys Asp Ala His Lys Ser Glu Val Ala His Arg 130 135 140 Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala 145 150 155 160 Phe Ala Gln Tyr Leu Gln Gln Ser Pro Phe Glu Asp His Val Lys Leu 165 170 175 Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser 180 185 190 Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu 195 200 205 Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys 210 215 220 Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys 225 230 235 240 Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val 245 250 255 Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr 260 265 270 Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu 275 280 285 Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln 290 295 300 Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg 305 310 315 320 Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser 325 330 335 Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg 340 345 350 Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu 355 360 365 Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu 370 375 380 Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu 385 390 395 400 Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro 405 410 415 Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met 420 425 430 Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp 435 440 445 Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe 450 455 460 Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu 465 470 475 480 Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala 485 490 495 Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys 500 505 510 Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu 515 520 525 Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg 530 535 540 Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val 545 550 555 560 Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu 565 570 575 Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn 580 585 590 Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr 595 600 605 Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala 610 615 620 Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr 625 630 635 640 Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln 645 650 655 Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys 660 665 670 Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe 675 680 685 Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu 690 695 700 Glu Gly Lys Lys Leu Val Ala Cys Val Glu Pro Leu Gly Met Glu Asn 705 710 715 720 Gly Asn Ile Ala Asn Ser Gln Ile Ala Ala Ser Ser Val Arg Val Thr 725 730 735 Phe Leu Gly Leu Gln His Trp Val Pro Glu Leu Ala Arg Leu Asn Arg 740 745 750 Ala Gly Met Val Asn Ala Trp Thr Pro Ser Ser Asn Asp Asp Asn Pro 755 760 765 Trp Ile Gln Val Asn Leu Leu Arg Arg Met Trp Val Thr Gly Val Val 770 775 780 Thr Gln Gly Ala Ser Arg Leu Ala Ser His Glu Tyr Leu Lys Ala Phe 785 790 795 800 Lys Val Ala Tyr Ser Leu Asn Gly His Glu Phe Asp Phe Ile His Asp 805 810 815 Val Asn Lys Lys His Lys Glu Phe Val Gly Asn Trp Asn Lys Asn Ala 820 825 830 Val His Val Asn Leu Phe Glu Thr Pro Val Glu Ala Gln Tyr Val Arg 835 840 845 Leu Tyr Pro Thr Ser Cys His Thr Ala Cys Thr Leu Arg Phe Glu Leu 850 855 860 Leu Gly Cys Glu Leu Asn Gly Cys Ala Asn Pro Leu Gly Leu Lys Asn 865 870 875 880 Asn Ser Ile Pro Asp Lys Gln Ile Thr Ala Ser Ser Ser Tyr Lys Thr 885 890 895 Trp Gly Leu His Leu Phe Ser Trp Asn Pro Ser Tyr Ala Arg Leu Asp 900 905 910 Lys Gln Gly Asn Phe Asn Ala Trp Val Ala Gly Ser Tyr Gly Asn Asp 915 920 925 Gln Trp Leu Gln Val Asp Leu Gly Ser Ser Lys Glu Val Thr Gly Ile 930 935 940 Ile Thr Gln Gly Ala Arg Asn Phe Gly Ser Val Gln Phe Val Ala Ser 945 950 955 960 Tyr Lys Val Ala Tyr Ser Asn Asp Ser Ala Asn Trp Thr Glu Tyr Gln 965 970 975 Asp Pro Arg Thr Gly Ser Ser Lys Ile Phe Pro Gly Asn Trp Asp Asn 980 985 990 His Ser His Lys Lys Asn Leu Phe Glu Thr Pro Ile Leu Ala Arg Tyr 995 1000 1005 Val Arg Ile Leu Pro Val Ala Trp His Asn Arg Ile Ala Leu Arg 1010 1015 1020 Leu Glu Leu Leu Gly Cys 1025 <210> 81 <211> 3087 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 81 gacatctgcg accccaatcc ttgcgagaat ggcggcattt gtctgcctgg actggccgat 60 ggcagcttct cttgtgaatg ccccgatggc ttcacagacc ccaattgcag ctctgtggtg 120 gaagtggcca gcgacgagga agaacctaca agcgctggcc cctgcacacc caatccatgt 180 cataatggcg gaacctgcga gatcagcgag gcctacagag gcgatacctt catcggctac 240 gtgtgcaagt gccccagagg cttcaatggc atccactgcc agcacaacat caacgagtgc 300 gaggtggaac catgcaagaa cggcggcatc tgtaccgacc tggtggccaa ttactcttgc 360 gagtgccctg gcgagttcat gggcagaaac tgccagtaca aggacgccca caagagcgag 420 gtggcccaca gattcaagga cctgggcgaa gagaacttca aggccctggt gctgatcgcc 480 ttcgctcagt atctccagca gagccctttc gaggaccacg tgaagctggt caacgaagtg 540 accgagttcg ccaagacctg tgtggccgat gagagcgccg agaactgtga caagagcctg 600 cacacactgt tcggcgacaa gctgtgtacc gtggccacac tgagagaaac ctacggcgag 660 atggccgact gctgtgccaa gcaagagccc gagagaaacg agtgcttcct ccagcacaag 720 gatgacaacc ccaacctgcc tagactcgtg cggcctgaag tggatgtgat gtgcaccgcc 780 tttcacgaca acgaggaaac cttcctgaag aagtacctgt acgagatcgc cagacggcac 840 ccctactttt atgcccctga gctgctgttc ttcgccaagc ggtataaggc cgccttcacc 900 gaatgttgcc aggccgctga taaggctgcc tgtctgctgc ctaagctgga cgagctgaga 960 gatgagggca aagccagctc tgccaagcag agactgaaat gcgccagcct ccagaagttc 1020 ggcgagagag cttttaaggc ctgggccgtt gccagactga gccagagatt tcctaaggcc 1080 gagtttgccg aggtgtccaa gctcgtgacc gatctgacaa aggtgcacac cgagtgctgt 1140 cacggcgatc tgctggaatg tgccgacgat agagccgacc tggccaagta tatctgcgag 1200 aaccaggaca gcatcagcag caagctgaaa gagtgctgcg agaagcccct gctggaaaag 1260 tctcactgta tcgccgaagt ggaaaacgac gagatgcccg ccgatctgcc ttctctggct 1320 gccgatttcg tggaaagcaa ggatgtgtgc aagaactacg ccgaggccaa agatgtgttt 1380 ctgggcatgt ttctgtatga gtacgcccgc agacaccccg actattctgt ggttctgctg 1440 ctgcggctgg ccaagacata cgagacaacc ctggaaaaat gctgcgccgc tgccgatcct 1500 cacgagtgtt atgccaaggt gttcgacgag ttcaagccac tggtggaaga accccagaac 1560 ctgatcaagc agaactgcga gctgttcgag cagctgggcg agtacaagtt ccagaatgcc 1620 ctgctcgtgc ggtacaccaa gaaagtgcct caggtgtcca cacctacact ggttgaggtg 1680 tcccggaatc tgggcaaagt gggcagcaag tgttgcaagc accctgaggc caagagaatg 1740 ccttgcgccg aggattacct gagcgtggtg ctgaatcagc tgtgcgtgct gcacgagaaa 1800 acccctgtgt ccgacagagt gaccaagtgc tgtaccgaga gcctcgtgaa cagaaggcct 1860 tgctttagcg ccctggaagt ggacgagaca tacgtgccca aagagttcaa cgccgagaca 1920 ttcaccttcc acgccgatat ctgcaccctg tccgagaaag agcggcagat caagaagcag 1980 acagccctgg tcgagctggt taagcacaag cccaaggcca ccaaagaaca gctgaaggcc 2040 gtgatggacg acttcgccgc ctttgtcgag aagtgctgca aggccgacga caaagagaca 2100 tgcttcgccg aagagggcaa gaaactggtg gcctgtgtgg aacccctcgg catggaaaac 2160 ggcaatatcg ccaatagcca gattgccgcc agcagcgtca gagtgacatt tctgggactg 2220 caacactggg tgcccgagct ggctagactg aatagagccg gcatggtcaa cgcctggaca 2280 cccagcagca acgacgataa cccctggatt caagtgaacc tgctgcggcg tatgtgggtc 2340 acaggtgttg ttacacaggg cgcaagcaga ctggcctctc acgagtacct gaaggccttt 2400 aaggtggcct acagcctgaa cggccacgag ttcgacttca tccacgacgt gaacaagaag 2460 cacaaagagt ttgtcggcaa ctggaacaag aacgccgtgc acgtgaacct gttcgagaca 2520 cctgtggaag cccagtacgt gcggctgtac cctacaagct gtcacaccgc ctgcactctg 2580 agattcgaac tgctgggatg cgagctgaac ggctgtgcta atcctctggg cctgaagaac 2640 aacagcatcc ccgataagca gatcaccgcc agctccagct ataagacatg gggcctgcac 2700 ctgttcagct ggaacccttc ttacgccaga ctggacaagc agggcaactt caatgcttgg 2760 gtggccggca gctacggcaa tgatcagtgg ctgcaagtgg atctgggcag cagcaaagaa 2820 gtgacaggca tcatcaccca aggggccaga aatttcggca gcgtgcagtt cgtggccagc 2880 tacaaagtgg cctactccaa cgacagcgcc aactggaccg agtatcagga ccctagaacc 2940 ggcagctcca agatcttccc cggcaattgg gacaaccaca gccacaagaa gaatctcttc 3000 gagactccca tcctggccag atatgtgcgg attctgcctg tggcctggca caacagaatc 3060 gccctgagac tggaactgct cggctgt 3087 <210> 82 <211> 942 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 82 Leu Asp Ile Cys Ser Lys Asn Pro Cys His Asn Gly Gly Leu Cys Glu 1 5 10 15 Glu Ile Ser Gln Glu Val Arg Gly Asp Val Phe Pro Ser Tyr Thr Cys 20 25 30 Thr Cys Leu Lys Gly Tyr Ala Gly Asn His Cys Glu Thr Lys Asp Ala 35 40 45 His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn 50 55 60 Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Ser 65 70 75 80 Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala 85 90 95 Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu 100 105 110 His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu 115 120 125 Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg 130 135 140 Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg 145 150 155 160 Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn 165 170 175 Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His 180 185 190 Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys 195 200 205 Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu 210 215 220 Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala 225 230 235 240 Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala 245 250 255 Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala 260 265 270 Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His 275 280 285 Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala 290 295 300 Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys 305 310 315 320 Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile 325 330 335 Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala 340 345 350 Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala 355 360 365 Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His 370 375 380 Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu 385 390 395 400 Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr 405 410 415 Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn 420 425 430 Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys 435 440 445 Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val 450 455 460 Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly 465 470 475 480 Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu 485 490 495 Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys 500 505 510 Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val 515 520 525 Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val 530 535 540 Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys 545 550 555 560 Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val 565 570 575 Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala 580 585 590 Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp 595 600 605 Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Cys 610 615 620 Ser Gly Pro Leu Gly Ile Glu Gly Gly Ile Ile Ser Asn Gln Gln Ile 625 630 635 640 Thr Ala Ser Ser Thr His Arg Ala Leu Phe Gly Leu Gln Lys Trp Tyr 645 650 655 Pro Tyr Tyr Ala Arg Leu Asn Lys Lys Gly Leu Ile Asn Ala Trp Thr 660 665 670 Ala Ala Glu Asn Asp Arg Trp Pro Trp Ile Gln Ile Asn Leu Gln Arg 675 680 685 Lys Met Arg Val Thr Gly Val Ile Thr Gln Gly Ala Lys Arg Ile Gly 690 695 700 Ser Pro Glu Tyr Ile Lys Ser Tyr Lys Ile Ala Tyr Ser Asn Asp Gly 705 710 715 720 Lys Thr Trp Ala Met Tyr Lys Val Lys Gly Thr Asn Glu Asp Met Val 725 730 735 Phe Arg Gly Asn Ile Asp Asn Asn Thr Pro Tyr Ala Asn Ser Phe Thr 740 745 750 Pro Pro Ile Lys Ala Gln Tyr Val Arg Leu Tyr Pro Gln Val Cys Arg 755 760 765 Arg His Cys Thr Leu Arg Met Glu Leu Leu Gly Cys Glu Leu Ser Gly 770 775 780 Cys Ser Glu Pro Leu Gly Met Lys Ser Gly His Ile Gln Asp Tyr Gln 785 790 795 800 Ile Thr Ala Ser Ser Ile Phe Arg Thr Leu Asn Met Asp Met Phe Thr 805 810 815 Trp Glu Pro Arg Lys Ala Arg Leu Asp Lys Gln Gly Lys Val Asn Ala 820 825 830 Trp Thr Ser Gly His Asn Asp Gln Ser Gln Trp Leu Gln Val Asp Leu 835 840 845 Leu Val Pro Thr Lys Val Thr Gly Ile Ile Thr Gln Gly Ala Lys Asp 850 855 860 Phe Gly His Val Gln Phe Val Gly Ser Tyr Lys Leu Ala Tyr Ser Asn 865 870 875 880 Asp Gly Glu His Trp Thr Val Tyr Gln Asp Glu Lys Gln Arg Lys Asp 885 890 895 Lys Val Phe Gln Gly Asn Phe Asp Asn Asp Thr His Arg Lys Asn Val 900 905 910 Ile Asp Pro Pro Ile Tyr Ala Arg His Ile Arg Ile Leu Pro Trp Ser 915 920 925 Trp Tyr Gly Arg Ile Thr Leu Arg Ser Glu Leu Leu Gly Cys 930 935 940 <210> 83 <211> 2826 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 83 ctggacatct gtagcaagaa cccttgccac aacggcggcc tgtgcgaaga gatttctcaa 60 gaagtgcggg gcgacgtttt ccccagctac acctgtacat gtctgaaggg ctacgccggc 120 aaccactgcg agacaaagga tgcccacaag agcgaggtgg cccacagatt caaggatctg 180 ggcgaagaga acttcaaggc cctggtgctg atcgccttcg ctcagtatct ccagcagagc 240 cctttcgagg accacgtgaa gctggtcaac gaagtgaccg agttcgccaa gacctgtgtg 300 gccgatgaga gcgccgagaa ctgtgataag agcctgcaca ccctgttcgg cgacaagctg 360 tgtacagtgg ccacactgag agaaacctac ggcgagatgg ccgactgctg tgccaagcaa 420 gagcccgaga gaaacgagtg cttcctccag cacaaggacg acaaccccaa cctgcctaga 480 ctcgtgcgac ccgaagtgga tgtgatgtgc accgcctttc acgacaacga ggaaaccttc 540 ctgaagaagt acctgtacga gatcgccaga cggcacccct acttttatgc ccctgagctg 600 ctgttcttcg ccaagcggta taaggccgcc ttcaccgaat gttgccaggc cgctgataag 660 gctgcctgtc tgctgcctaa gctggacgag ctgagagatg agggcaaagc cagctctgcc 720 aagcagagac tgaaatgcgc cagcctccag aagttcggcg agagagcttt taaggcctgg 780 gccgttgcca gactgagcca gagatttcct aaggccgagt ttgccgaggt gtccaagctc 840 gtgaccgatc tgacaaaggt gcacaccgag tgctgtcacg gcgatctgct ggaatgtgcc 900 gacgatagag ccgacctggc caagtacatc tgcgagaacc aggacagcat cagcagcaag 960 ctgaaagagt gctgcgagaa gcccctgctg gaaaagtctc actgtatcgc cgaggtggaa 1020 aacgacgaga tgcctgccga tctgcctagc ctggctgccg atttcgtgga aagcaaggac 1080 gtgtgcaaga actacgccga ggccaaggat gtgtttctgg gcatgtttct gtatgagtac 1140 gcccgcagac accccgacta ttctgtggtt ctgctgctgc ggctggccaa aacctacgag 1200 acaaccctgg aaaaatgctg cgccgctgcc gatcctcacg agtgttatgc caaggtgttc 1260 gacgagttca agcctctggt ggaagaaccc cagaacctga tcaagcagaa ctgcgagctg 1320 ttcgagcagc tgggcgagta caagttccag aatgccctgc tcgtgcggta caccaagaaa 1380 gtgcctcagg tgtccacacc tacactggtt gaggtgtccc ggaatctggg caaagtgggc 1440 agcaagtgtt gcaagcaccc tgaggccaag agaatgcctt gcgccgagga ttacctgagc 1500 gtggtgctga atcagctgtg cgtgctgcac gagaaaaccc ctgtgtccga cagagtgacc 1560 aagtgctgta ccgagagcct cgtgaacaga aggccttgct ttagcgccct ggaagtggac 1620 gagacatacg tgcccaaaga gttcaacgcc gagacattca ccttccacgc cgacatctgc 1680 accctgtccg agaaagagcg gcagatcaag aagcagacag ccctggtcga gctggttaag 1740 cacaagccca aggccaccaa agaacagctg aaggccgtga tggacgactt cgccgccttt 1800 gtcgagaagt gctgcaaggc cgacgacaaa gagacatgct tcgccgaaga gggcaagaaa 1860 ctggtggcct gttctggccc tctgggcatc gaaggcggca tcatcagcaa tcagcagatc 1920 accgccagca gcacccacag agcactgttt ggcctgcaaa agtggtatcc ctactacgcc 1980 cggctgaaca agaagggcct gattaacgcc tggacagccg ccgagaatga cagatggccc 2040 tggattcaga tcaacctcca gcggaagatg agagtgaccg gcgttatcac acagggcgca 2100 aagagaatcg gctcccctga gtacatcaag agctacaaga tcgcctacag caacgacggc 2160 aagacctggg ccatgtacaa agtgaagggc accaacgagg acatggtgtt ccggggcaac 2220 atcgacaaca acacccctta cgccaacagc ttcacccctc ctatcaaggc ccagtacgtg 2280 cggctgtacc ctcaagtgtg cagaaggcac tgtaccctga gaatggaact gctgggctgc 2340 gaactgtctg gctgttctga gccactggga atgaagtccg gccacatcca ggactaccag 2400 attaccgcct ccagcatctt cagaaccctg aacatggata tgttcacctg ggagccccgg 2460 aaggccagac tggataagca gggaaaagtg aatgcctgga ccagcggcca caacgaccag 2520 tctcaatggc tgcaagtgga cctgctggtg cctaccaaag tgaccggaat catcacccaa 2580 ggcgctaagg atttcggcca cgtgcagttc gtgggctcct acaagctggc ctactccaat 2640 gatggcgagc actggaccgt gtaccaggac gagaagcagc ggaaggataa ggtgttccag 2700 ggaaacttcg ataacgatac ccaccggaag aacgtgatcg accctccaat ctacgccaga 2760 cacatcagaa tcctgccttg gtcttggtac ggcagaatca ccctgagatc cgagctgctg 2820 ggatgc 2826 <210> 84 <211> 968 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 84 Asp Ile Cys Asp Pro Asn Pro Cys Glu Asn Gly Gly Ile Cys Leu Pro 1 5 10 15 Gly Leu Ala Asp Gly Ser Phe Ser Cys Glu Cys Pro Asp Gly Phe Thr 20 25 30 Asp Pro Asn Cys Ser Ser Val Val Glu Val Ala Ser Asp Glu Glu Glu 35 40 45 Pro Thr Gly Ser Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys 50 55 60 Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala 65 70 75 80 Gln Tyr Leu Gln Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn 85 90 95 Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu 100 105 110 Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr 115 120 125 Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala 130 135 140 Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp 145 150 155 160 Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys 165 170 175 Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr 180 185 190 Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe 195 200 205 Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala 210 215 220 Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu 225 230 235 240 Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln 245 250 255 Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser 260 265 270 Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr 275 280 285 Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu 290 295 300 Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln 305 310 315 320 Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu 325 330 335 Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala 340 345 350 Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys 355 360 365 Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr 370 375 380 Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg 385 390 395 400 Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala 405 410 415 Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu 420 425 430 Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu 435 440 445 Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr 450 455 460 Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg 465 470 475 480 Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys 485 490 495 Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu 500 505 510 Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys 515 520 525 Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu 530 535 540 Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr 545 550 555 560 Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys 565 570 575 Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr 580 585 590 Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu 595 600 605 Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly 610 615 620 Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Ser 625 630 635 640 Gly Gly Ser Gly Gly Ser Gly Gly Ser Cys Ser Gly Pro Leu Gly Ile 645 650 655 Glu Gly Gly Ile Ile Ser Asn Gln Gln Ile Thr Ala Ser Ser Thr His 660 665 670 Arg Ala Leu Phe Gly Leu Gln Lys Trp Tyr Pro Tyr Tyr Ala Arg Leu 675 680 685 Asn Lys Lys Gly Leu Ile Asn Ala Trp Thr Ala Ala Glu Asn Asp Arg 690 695 700 Trp Pro Trp Ile Gln Ile Asn Leu Gln Arg Lys Met Arg Val Thr Gly 705 710 715 720 Val Ile Thr Gln Gly Ala Lys Arg Ile Gly Ser Pro Glu Tyr Ile Lys 725 730 735 Ser Tyr Lys Ile Ala Tyr Ser Asn Asp Gly Lys Thr Trp Ala Met Tyr 740 745 750 Lys Val Lys Gly Thr Asn Glu Asp Met Val Phe Arg Gly Asn Ile Asp 755 760 765 Asn Asn Thr Pro Tyr Ala Asn Ser Phe Thr Pro Pro Ile Lys Ala Gln 770 775 780 Tyr Val Arg Leu Tyr Pro Gln Val Cys Arg Arg His Cys Thr Leu Arg 785 790 795 800 Met Glu Leu Leu Gly Cys Glu Leu Ser Gly Cys Ser Glu Pro Leu Gly 805 810 815 Met Lys Ser Gly His Ile Gln Asp Tyr Gln Ile Thr Ala Ser Ser Ile 820 825 830 Phe Arg Thr Leu Asn Met Asp Met Phe Thr Trp Glu Pro Arg Lys Ala 835 840 845 Arg Leu Asp Lys Gln Gly Lys Val Asn Ala Trp Thr Ser Gly His Asn 850 855 860 Asp Gln Ser Gln Trp Leu Gln Val Asp Leu Leu Val Pro Thr Lys Val 865 870 875 880 Thr Gly Ile Ile Thr Gln Gly Ala Lys Asp Phe Gly His Val Gln Phe 885 890 895 Val Gly Ser Tyr Lys Leu Ala Tyr Ser Asn Asp Gly Glu His Trp Thr 900 905 910 Val Tyr Gln Asp Glu Lys Gln Arg Lys Asp Lys Val Phe Gln Gly Asn 915 920 925 Phe Asp Asn Asp Thr His Arg Lys Asn Val Ile Asp Pro Pro Ile Tyr 930 935 940 Ala Arg His Ile Arg Ile Leu Pro Trp Ser Trp Tyr Gly Arg Ile Thr 945 950 955 960 Leu Arg Ser Glu Leu Leu Gly Cys 965 <210> 85 <211> 963 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 85 Ser Ala Gly Pro Cys Thr Pro Asn Pro Cys His Asn Gly Gly Thr Cys 1 5 10 15 Glu Ile Ser Glu Ala Tyr Arg Gly Asp Thr Phe Ile Gly Tyr Val Cys 20 25 30 Lys Cys Pro Arg Gly Phe Asn Gly Ile His Cys Gln His Gly Ser Asp 35 40 45 Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu 50 55 60 Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln 65 70 75 80 Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe 85 90 95 Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser 100 105 110 Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg 115 120 125 Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu 130 135 140 Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro 145 150 155 160 Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp 165 170 175 Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg 180 185 190 His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr 195 200 205 Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys 210 215 220 Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser 225 230 235 240 Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg 245 250 255 Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys 260 265 270 Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val 275 280 285 His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg 290 295 300 Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser 305 310 315 320 Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys 325 330 335 Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu 340 345 350 Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu 355 360 365 Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg 370 375 380 His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr 385 390 395 400 Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys 405 410 415 Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln 420 425 430 Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr 435 440 445 Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln 450 455 460 Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val 465 470 475 480 Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala 485 490 495 Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu 500 505 510 Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu 515 520 525 Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr 530 535 540 Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile 545 550 555 560 Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu 565 570 575 Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys 580 585 590 Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala 595 600 605 Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala 610 615 620 Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Ser Gly Gly Ser Gly Gly 625 630 635 640 Ser Gly Gly Ser Cys Ser Gly Pro Leu Gly Ile Glu Gly Gly Ile Ile 645 650 655 Ser Asn Gln Gln Ile Thr Ala Ser Ser Thr His Arg Ala Leu Phe Gly 660 665 670 Leu Gln Lys Trp Tyr Pro Tyr Tyr Ala Arg Leu Asn Lys Lys Gly Leu 675 680 685 Ile Asn Ala Trp Thr Ala Ala Glu Asn Asp Arg Trp Pro Trp Ile Gln 690 695 700 Ile Asn Leu Gln Arg Lys Met Arg Val Thr Gly Val Ile Thr Gln Gly 705 710 715 720 Ala Lys Arg Ile Gly Ser Pro Glu Tyr Ile Lys Ser Tyr Lys Ile Ala 725 730 735 Tyr Ser Asn Asp Gly Lys Thr Trp Ala Met Tyr Lys Val Lys Gly Thr 740 745 750 Asn Glu Asp Met Val Phe Arg Gly Asn Ile Asp Asn Asn Thr Pro Tyr 755 760 765 Ala Asn Ser Phe Thr Pro Pro Ile Lys Ala Gln Tyr Val Arg Leu Tyr 770 775 780 Pro Gln Val Cys Arg Arg His Cys Thr Leu Arg Met Glu Leu Leu Gly 785 790 795 800 Cys Glu Leu Ser Gly Cys Ser Glu Pro Leu Gly Met Lys Ser Gly His 805 810 815 Ile Gln Asp Tyr Gln Ile Thr Ala Ser Ser Ile Phe Arg Thr Leu Asn 820 825 830 Met Asp Met Phe Thr Trp Glu Pro Arg Lys Ala Arg Leu Asp Lys Gln 835 840 845 Gly Lys Val Asn Ala Trp Thr Ser Gly His Asn Asp Gln Ser Gln Trp 850 855 860 Leu Gln Val Asp Leu Leu Val Pro Thr Lys Val Thr Gly Ile Ile Thr 865 870 875 880 Gln Gly Ala Lys Asp Phe Gly His Val Gln Phe Val Gly Ser Tyr Lys 885 890 895 Leu Ala Tyr Ser Asn Asp Gly Glu His Trp Thr Val Tyr Gln Asp Glu 900 905 910 Lys Gln Arg Lys Asp Lys Val Phe Gln Gly Asn Phe Asp Asn Asp Thr 915 920 925 His Arg Lys Asn Val Ile Asp Pro Pro Ile Tyr Ala Arg His Ile Arg 930 935 940 Ile Leu Pro Trp Ser Trp Tyr Gly Arg Ile Thr Leu Arg Ser Glu Leu 945 950 955 960 Leu Gly Cys <210> 86 <211> 957 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 86 Asn Ile Asn Glu Cys Glu Val Glu Pro Cys Lys Asn Gly Gly Ile Cys 1 5 10 15 Thr Asp Leu Val Ala Asn Tyr Ser Cys Glu Cys Pro Gly Glu Phe Met 20 25 30 Gly Arg Asn Cys Gln Tyr Lys Gly Ser Asp Ala His Lys Ser Glu Val 35 40 45 Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val 50 55 60 Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Ser Pro Phe Glu Asp His 65 70 75 80 Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala 85 90 95 Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly 100 105 110 Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met 115 120 125 Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu 130 135 140 Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu 145 150 155 160 Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu 165 170 175 Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala 180 185 190 Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu 195 200 205 Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp 210 215 220 Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys 225 230 235 240 Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala 245 250 255 Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val 260 265 270 Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His 275 280 285 Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr 290 295 300 Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys 305 310 315 320 Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn 325 330 335 Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu 340 345 350 Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu 355 360 365 Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val 370 375 380 Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys 385 390 395 400 Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp 405 410 415 Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn 420 425 430 Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu 435 440 445 Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu 450 455 460 Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys 465 470 475 480 His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val 485 490 495 Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp 500 505 510 Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys 515 520 525 Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn 530 535 540 Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys 545 550 555 560 Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His 565 570 575 Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe 580 585 590 Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys 595 600 605 Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu 610 615 620 Gly Leu Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Cys Ser 625 630 635 640 Gly Pro Leu Gly Ile Glu Gly Gly Ile Ile Ser Asn Gln Gln Ile Thr 645 650 655 Ala Ser Ser Thr His Arg Ala Leu Phe Gly Leu Gln Lys Trp Tyr Pro 660 665 670 Tyr Tyr Ala Arg Leu Asn Lys Lys Gly Leu Ile Asn Ala Trp Thr Ala 675 680 685 Ala Glu Asn Asp Arg Trp Pro Trp Ile Gln Ile Asn Leu Gln Arg Lys 690 695 700 Met Arg Val Thr Gly Val Ile Thr Gln Gly Ala Lys Arg Ile Gly Ser 705 710 715 720 Pro Glu Tyr Ile Lys Ser Tyr Lys Ile Ala Tyr Ser Asn Asp Gly Lys 725 730 735 Thr Trp Ala Met Tyr Lys Val Lys Gly Thr Asn Glu Asp Met Val Phe 740 745 750 Arg Gly Asn Ile Asp Asn Asn Thr Pro Tyr Ala Asn Ser Phe Thr Pro 755 760 765 Pro Ile Lys Ala Gln Tyr Val Arg Leu Tyr Pro Gln Val Cys Arg Arg 770 775 780 His Cys Thr Leu Arg Met Glu Leu Leu Gly Cys Glu Leu Ser Gly Cys 785 790 795 800 Ser Glu Pro Leu Gly Met Lys Ser Gly His Ile Gln Asp Tyr Gln Ile 805 810 815 Thr Ala Ser Ser Ile Phe Arg Thr Leu Asn Met Asp Met Phe Thr Trp 820 825 830 Glu Pro Arg Lys Ala Arg Leu Asp Lys Gln Gly Lys Val Asn Ala Trp 835 840 845 Thr Ser Gly His Asn Asp Gln Ser Gln Trp Leu Gln Val Asp Leu Leu 850 855 860 Val Pro Thr Lys Val Thr Gly Ile Ile Thr Gln Gly Ala Lys Asp Phe 865 870 875 880 Gly His Val Gln Phe Val Gly Ser Tyr Lys Leu Ala Tyr Ser Asn Asp 885 890 895 Gly Glu His Trp Thr Val Tyr Gln Asp Glu Lys Gln Arg Lys Asp Lys 900 905 910 Val Phe Gln Gly Asn Phe Asp Asn Asp Thr His Arg Lys Asn Val Ile 915 920 925 Asp Pro Pro Ile Tyr Ala Arg His Ile Arg Ile Leu Pro Trp Ser Trp 930 935 940 Tyr Gly Arg Ile Thr Leu Arg Ser Glu Leu Leu Gly Cys 945 950 955 <210> 87 <211> 1013 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 87 Asp Ile Cys Asp Pro Asn Pro Cys Glu Asn Gly Gly Ile Cys Leu Pro 1 5 10 15 Gly Leu Ala Asp Gly Ser Phe Ser Cys Glu Cys Pro Asp Gly Phe Thr 20 25 30 Asp Pro Asn Cys Ser Ser Val Val Glu Val Ala Ser Asp Glu Glu Glu 35 40 45 Pro Thr Ser Ala Gly Pro Cys Thr Pro Asn Pro Cys His Asn Gly Gly 50 55 60 Thr Cys Glu Ile Ser Glu Ala Tyr Arg Gly Asp Thr Phe Ile Gly Tyr 65 70 75 80 Val Cys Lys Cys Pro Arg Gly Phe Asn Gly Ile His Cys Gln His Gly 85 90 95 Ser Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly 100 105 110 Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu 115 120 125 Gln Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr 130 135 140 Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp 145 150 155 160 Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr 165 170 175 Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu 180 185 190 Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn 195 200 205 Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe 210 215 220 His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala 225 230 235 240 Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys 245 250 255 Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala 260 265 270 Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala 275 280 285 Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly 290 295 300 Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe 305 310 315 320 Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr 325 330 335 Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 340 345 350 Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile 355 360 365 Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser 370 375 380 His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro 385 390 395 400 Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr 405 410 415 Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala 420 425 430 Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys 435 440 445 Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His 450 455 460 Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu 465 470 475 480 Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly 485 490 495 Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val 500 505 510 Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly 515 520 525 Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro 530 535 540 Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu 545 550 555 560 His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu 565 570 575 Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu 580 585 590 Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala 595 600 605 Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr 610 615 620 Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln 625 630 635 640 Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys 645 650 655 Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu 660 665 670 Val Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Ser Gly Gly Ser 675 680 685 Gly Gly Ser Gly Gly Ser Cys Ser Gly Pro Leu Gly Ile Glu Gly Gly 690 695 700 Ile Ile Ser Asn Gln Gln Ile Thr Ala Ser Ser Thr His Arg Ala Leu 705 710 715 720 Phe Gly Leu Gln Lys Trp Tyr Pro Tyr Tyr Ala Arg Leu Asn Lys Lys 725 730 735 Gly Leu Ile Asn Ala Trp Thr Ala Ala Glu Asn Asp Arg Trp Pro Trp 740 745 750 Ile Gln Ile Asn Leu Gln Arg Lys Met Arg Val Thr Gly Val Ile Thr 755 760 765 Gln Gly Ala Lys Arg Ile Gly Ser Pro Glu Tyr Ile Lys Ser Tyr Lys 770 775 780 Ile Ala Tyr Ser Asn Asp Gly Lys Thr Trp Ala Met Tyr Lys Val Lys 785 790 795 800 Gly Thr Asn Glu Asp Met Val Phe Arg Gly Asn Ile Asp Asn Asn Thr 805 810 815 Pro Tyr Ala Asn Ser Phe Thr Pro Pro Ile Lys Ala Gln Tyr Val Arg 820 825 830 Leu Tyr Pro Gln Val Cys Arg Arg His Cys Thr Leu Arg Met Glu Leu 835 840 845 Leu Gly Cys Glu Leu Ser Gly Cys Ser Glu Pro Leu Gly Met Lys Ser 850 855 860 Gly His Ile Gln Asp Tyr Gln Ile Thr Ala Ser Ser Ile Phe Arg Thr 865 870 875 880 Leu Asn Met Asp Met Phe Thr Trp Glu Pro Arg Lys Ala Arg Leu Asp 885 890 895 Lys Gln Gly Lys Val Asn Ala Trp Thr Ser Gly His Asn Asp Gln Ser 900 905 910 Gln Trp Leu Gln Val Asp Leu Leu Val Pro Thr Lys Val Thr Gly Ile 915 920 925 Ile Thr Gln Gly Ala Lys Asp Phe Gly His Val Gln Phe Val Gly Ser 930 935 940 Tyr Lys Leu Ala Tyr Ser Asn Asp Gly Glu His Trp Thr Val Tyr Gln 945 950 955 960 Asp Glu Lys Gln Arg Lys Asp Lys Val Phe Gln Gly Asn Phe Asp Asn 965 970 975 Asp Thr His Arg Lys Asn Val Ile Asp Pro Pro Ile Tyr Ala Arg His 980 985 990 Ile Arg Ile Leu Pro Trp Ser Trp Tyr Gly Arg Ile Thr Leu Arg Ser 995 1000 1005 Glu Leu Leu Gly Cys 1010 <210> 88 <211> 1002 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 88 Ser Ala Gly Pro Cys Thr Pro Asn Pro Cys His Asn Gly Gly Thr Cys 1 5 10 15 Glu Ile Ser Glu Ala Tyr Arg Gly Asp Thr Phe Ile Gly Tyr Val Cys 20 25 30 Lys Cys Pro Arg Gly Phe Asn Gly Ile His Cys Gln His Asn Ile Asn 35 40 45 Glu Cys Glu Val Glu Pro Cys Lys Asn Gly Gly Ile Cys Thr Asp Leu 50 55 60 Val Ala Asn Tyr Ser Cys Glu Cys Pro Gly Glu Phe Met Gly Arg Asn 65 70 75 80 Cys Gln Tyr Lys Gly Ser Asp Ala His Lys Ser Glu Val Ala His Arg 85 90 95 Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala 100 105 110 Phe Ala Gln Tyr Leu Gln Gln Ser Pro Phe Glu Asp His Val Lys Leu 115 120 125 Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser 130 135 140 Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu 145 150 155 160 Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys 165 170 175 Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys 180 185 190 Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val 195 200 205 Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr 210 215 220 Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu 225 230 235 240 Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln 245 250 255 Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg 260 265 270 Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser 275 280 285 Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg 290 295 300 Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu 305 310 315 320 Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu 325 330 335 Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu 340 345 350 Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro 355 360 365 Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met 370 375 380 Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp 385 390 395 400 Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe 405 410 415 Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu 420 425 430 Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala 435 440 445 Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys 450 455 460 Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu 465 470 475 480 Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg 485 490 495 Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val 500 505 510 Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu 515 520 525 Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn 530 535 540 Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr 545 550 555 560 Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala 565 570 575 Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr 580 585 590 Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln 595 600 605 Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys 610 615 620 Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe 625 630 635 640 Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu 645 650 655 Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly 660 665 670 Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Cys Ser Gly Pro Leu 675 680 685 Gly Ile Glu Gly Gly Ile Ile Ser Asn Gln Gln Ile Thr Ala Ser Ser 690 695 700 Thr His Arg Ala Leu Phe Gly Leu Gln Lys Trp Tyr Pro Tyr Tyr Ala 705 710 715 720 Arg Leu Asn Lys Lys Gly Leu Ile Asn Ala Trp Thr Ala Ala Glu Asn 725 730 735 Asp Arg Trp Pro Trp Ile Gln Ile Asn Leu Gln Arg Lys Met Arg Val 740 745 750 Thr Gly Val Ile Thr Gln Gly Ala Lys Arg Ile Gly Ser Pro Glu Tyr 755 760 765 Ile Lys Ser Tyr Lys Ile Ala Tyr Ser Asn Asp Gly Lys Thr Trp Ala 770 775 780 Met Tyr Lys Val Lys Gly Thr Asn Glu Asp Met Val Phe Arg Gly Asn 785 790 795 800 Ile Asp Asn Asn Thr Pro Tyr Ala Asn Ser Phe Thr Pro Pro Ile Lys 805 810 815 Ala Gln Tyr Val Arg Leu Tyr Pro Gln Val Cys Arg Arg His Cys Thr 820 825 830 Leu Arg Met Glu Leu Leu Gly Cys Glu Leu Ser Gly Cys Ser Glu Pro 835 840 845 Leu Gly Met Lys Ser Gly His Ile Gln Asp Tyr Gln Ile Thr Ala Ser 850 855 860 Ser Ile Phe Arg Thr Leu Asn Met Asp Met Phe Thr Trp Glu Pro Arg 865 870 875 880 Lys Ala Arg Leu Asp Lys Gln Gly Lys Val Asn Ala Trp Thr Ser Gly 885 890 895 His Asn Asp Gln Ser Gln Trp Leu Gln Val Asp Leu Leu Val Pro Thr 900 905 910 Lys Val Thr Gly Ile Ile Thr Gln Gly Ala Lys Asp Phe Gly His Val 915 920 925 Gln Phe Val Gly Ser Tyr Lys Leu Ala Tyr Ser Asn Asp Gly Glu His 930 935 940 Trp Thr Val Tyr Gln Asp Glu Lys Gln Arg Lys Asp Lys Val Phe Gln 945 950 955 960 Gly Asn Phe Asp Asn Asp Thr His Arg Lys Asn Val Ile Asp Pro Pro 965 970 975 Ile Tyr Ala Arg His Ile Arg Ile Leu Pro Trp Ser Trp Tyr Gly Arg 980 985 990 Ile Thr Leu Arg Ser Glu Leu Leu Gly Cys 995 1000 <210> 89 <211> 1007 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 89 Asp Ile Cys Asp Pro Asn Pro Cys Glu Asn Gly Gly Ile Cys Leu Pro 1 5 10 15 Gly Leu Ala Asp Gly Ser Phe Ser Cys Glu Cys Pro Asp Gly Phe Thr 20 25 30 Asp Pro Asn Cys Ser Ser Val Val Glu Val Ala Ser Asp Glu Glu Glu 35 40 45 Pro Thr Asn Ile Asn Glu Cys Glu Val Glu Pro Cys Lys Asn Gly Gly 50 55 60 Ile Cys Thr Asp Leu Val Ala Asn Tyr Ser Cys Glu Cys Pro Gly Glu 65 70 75 80 Phe Met Gly Arg Asn Cys Gln Tyr Lys Gly Ser Asp Ala His Lys Ser 85 90 95 Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala 100 105 110 Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Ser Pro Phe Glu 115 120 125 Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys 130 135 140 Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu 145 150 155 160 Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly 165 170 175 Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys 180 185 190 Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg 195 200 205 Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr 210 215 220 Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe 225 230 235 240 Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe 245 250 255 Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys 260 265 270 Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg 275 280 285 Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala 290 295 300 Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala 305 310 315 320 Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys 325 330 335 Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala 340 345 350 Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu 355 360 365 Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val 370 375 380 Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe 385 390 395 400 Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val 405 410 415 Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr 420 425 430 Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu 435 440 445 Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val 450 455 460 Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys 465 470 475 480 Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn 485 490 495 Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro 500 505 510 Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys 515 520 525 Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu 530 535 540 Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val 545 550 555 560 Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg 565 570 575 Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu 580 585 590 Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser 595 600 605 Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val 610 615 620 Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp 625 630 635 640 Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu 645 650 655 Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala 660 665 670 Ala Leu Gly Leu Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 675 680 685 Cys Ser Gly Pro Leu Gly Ile Glu Gly Gly Ile Ile Ser Asn Gln Gln 690 695 700 Ile Thr Ala Ser Ser Thr His Arg Ala Leu Phe Gly Leu Gln Lys Trp 705 710 715 720 Tyr Pro Tyr Tyr Ala Arg Leu Asn Lys Lys Gly Leu Ile Asn Ala Trp 725 730 735 Thr Ala Ala Glu Asn Asp Arg Trp Pro Trp Ile Gln Ile Asn Leu Gln 740 745 750 Arg Lys Met Arg Val Thr Gly Val Ile Thr Gln Gly Ala Lys Arg Ile 755 760 765 Gly Ser Pro Glu Tyr Ile Lys Ser Tyr Lys Ile Ala Tyr Ser Asn Asp 770 775 780 Gly Lys Thr Trp Ala Met Tyr Lys Val Lys Gly Thr Asn Glu Asp Met 785 790 795 800 Val Phe Arg Gly Asn Ile Asp Asn Asn Thr Pro Tyr Ala Asn Ser Phe 805 810 815 Thr Pro Pro Ile Lys Ala Gln Tyr Val Arg Leu Tyr Pro Gln Val Cys 820 825 830 Arg Arg His Cys Thr Leu Arg Met Glu Leu Leu Gly Cys Glu Leu Ser 835 840 845 Gly Cys Ser Glu Pro Leu Gly Met Lys Ser Gly His Ile Gln Asp Tyr 850 855 860 Gln Ile Thr Ala Ser Ser Ile Phe Arg Thr Leu Asn Met Asp Met Phe 865 870 875 880 Thr Trp Glu Pro Arg Lys Ala Arg Leu Asp Lys Gln Gly Lys Val Asn 885 890 895 Ala Trp Thr Ser Gly His Asn Asp Gln Ser Gln Trp Leu Gln Val Asp 900 905 910 Leu Leu Val Pro Thr Lys Val Thr Gly Ile Ile Thr Gln Gly Ala Lys 915 920 925 Asp Phe Gly His Val Gln Phe Val Gly Ser Tyr Lys Leu Ala Tyr Ser 930 935 940 Asn Asp Gly Glu His Trp Thr Val Tyr Gln Asp Glu Lys Gln Arg Lys 945 950 955 960 Asp Lys Val Phe Gln Gly Asn Phe Asp Asn Asp Thr His Arg Lys Asn 965 970 975 Val Ile Asp Pro Pro Ile Tyr Ala Arg His Ile Arg Ile Leu Pro Trp 980 985 990 Ser Trp Tyr Gly Arg Ile Thr Leu Arg Ser Glu Leu Leu Gly Cys 995 1000 1005 <210> 90 <211> 2904 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 90 gacatctgcg accccaaccc ctgcgagaac ggcggcatct gcctgcccgg cctggccgac 60 ggcagcttca gctgcgagtg ccccgacggc ttcaccgacc ccaactgcag cagcgtggtg 120 gaggtggcca gcgacgagga ggagcccacc ggcagcgacg cccacaagag cgaggtggcc 180 caccggttca aggacctggg cgaggagaac ttcaaggccc tggtgctgat cgccttcgcc 240 cagtacctgc agcagagccc cttcgaggac cacgtgaagc tggtgaacga ggtgaccgag 300 ttcgccaaga cctgcgtggc cgacgagagc gccgagaact gcgacaagag cctgcacacc 360 ctgttcggcg acaagctgtg caccgtggcc accctgcggg agacctacgg cgagatggcc 420 gactgctgcg ccaagcagga gcccgagcgg aacgagtgct tcctgcagca caaggacgac 480 aaccccaacc tgccccggct ggtgcggccc gaggtggacg tgatgtgcac cgccttccac 540 gacaacgagg agaccttcct gaagaagtac ctgtacgaga tcgcccggcg gcacccctac 600 ttctacgccc ccgagctgct gttcttcgcc aagcggtaca aggccgcctt caccgagtgc 660 tgccaggccg ccgacaaggc cgcctgcctg ctgcccaagc tggacgagct gcgggacgag 720 ggcaaggcca gcagcgccaa gcagcggctg aagtgcgcca gcctgcagaa gttcggcgag 780 cgggccttca aggcctgggc cgtggcccgg ctgagccagc ggttccccaa ggccgagttc 840 gccgaggtga gcaagctggt gaccgacctg accaaggtgc acaccgagtg ctgccacggc 900 gacctgctgg agtgcgccga cgaccgggcc gacctggcca agtacatctg cgagaaccag 960 gacagcatca gcagcaagct gaaggagtgc tgcgagaagc ccctgctgga gaagagccac 1020 tgcatcgccg aggtggagaa cgacgagatg cccgccgacc tgcccagcct ggccgccgac 1080 ttcgtggaga gcaaggacgt gtgcaagaac tacgccgagg ccaaggacgt gttcctgggc 1140 atgttcctgt acgagtacgc ccggcggcac cccgactaca gcgtggtgct gctgctgcgg 1200 ctggccaaga cctacgagac caccctggag aagtgctgcg ccgccgccga cccccacgag 1260 tgctacgcca aggtgttcga cgagttcaag cccctggtgg aggagcccca gaacctgatc 1320 aagcagaact gcgagctgtt cgagcagctg ggcgagtaca agttccagaa cgccctgctg 1380 gtgcggtaca ccaagaaggt gccccaggtg agcaccccca ccctggtgga ggtgagccgg 1440 aacctgggca aggtgggcag caagtgctgc aagcaccccg aggccaagcg gatgccctgc 1500 gccgaggact acctgagcgt ggtgctgaac cagctgtgcg tgctgcacga gaagaccccc 1560 gtgagcgacc gggtgaccaa gtgctgcacc gagagcctgg tgaaccggcg gccctgcttc 1620 agcgccctgg aggtggacga gacctacgtg cccaaggagt tcaacgccga gaccttcacc 1680 ttccacgccg acatctgcac cctgagcgag aaggagcggc agatcaagaa gcagaccgcc 1740 ctggtggagc tggtgaagca caagcccaag gccaccaagg agcagctgaa ggccgtgatg 1800 gacgacttcg ccgccttcgt ggagaagtgc tgcaaggccg acgacaagga gacctgcttc 1860 gccgaggagg gcaagaagct ggtggccgcc agccaggccg ccctgggcct gggcggcagc 1920 ggcggcagcg gcggcagcgg cggcagctgc agcggccccc tgggcatcga gggcggcatc 1980 atcagcaacc agcagatcac cgccagcagc acccaccggg ccctgttcgg cctgcagaag 2040 tggtacccct actacgcccg gctgaacaag aagggcctga tcaacgcctg gaccgccgcc 2100 gagaacgacc ggtggccctg gatccagatc aacctgcagc ggaagatgcg ggtgaccggc 2160 gtgatcaccc agggcgccaa gcggatcggc agccccgagt acatcaagag ctacaagatc 2220 gcctacagca acgacggcaa gacctgggcc atgtacaagg tgaagggcac caacgaggac 2280 atggtgttcc ggggcaacat cgacaacaac accccctacg ccaacagctt cacccccccc 2340 atcaaggccc agtacgtgcg gctgtacccc caggtgtgcc ggcggcactg caccctgcgg 2400 atggagctgc tgggctgcga gctgagcggc tgcagcgagc ccctgggcat gaagagcggc 2460 cacatccagg actaccagat caccgccagc agcatcttcc ggaccctgaa catggacatg 2520 ttcacctggg agccccggaa ggcccggctg gacaagcagg gcaaggtgaa cgcctggacc 2580 agcggccaca acgaccagag ccagtggctg caggtggacc tgctggtgcc caccaaggtg 2640 accggcatca tcacccaggg cgccaaggac ttcggccacg tgcagttcgt gggcagctac 2700 aagctggcct acagcaacga cggcgagcac tggaccgtgt accaggacga gaagcagcgg 2760 aaggacaagg tgttccaggg caacttcgac aacgacaccc accggaagaa cgtgatcgac 2820 ccccccatct acgcccggca catccggatc ctgccctgga gctggtacgg ccggatcacc 2880 ctgcggagcg agctgctggg ctgc 2904 <210> 91 <211> 2889 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 91 agcgccggcc cctgcacccc caacccctgc cacaacggcg gcacctgcga gatcagcgag 60 gcctaccggg gcgacacctt catcggctac gtgtgcaagt gcccccgggg cttcaacggc 120 atccactgcc agcacggcag cgacgcccac aagagcgagg tggcccaccg gttcaaggac 180 ctgggcgagg agaacttcaa ggccctggtg ctgatcgcct tcgcccagta cctgcagcag 240 agccccttcg aggaccacgt gaagctggtg aacgaggtga ccgagttcgc caagacctgc 300 gtggccgacg agagcgccga gaactgcgac aagagcctgc acaccctgtt cggcgacaag 360 ctgtgcaccg tggccaccct gcgggagacc tacggcgaga tggccgactg ctgcgccaag 420 caggagcccg agcggaacga gtgcttcctg cagcacaagg acgacaaccc caacctgccc 480 cggctggtgc ggcccgaggt ggacgtgatg tgcaccgcct tccacgacaa cgaggagacc 540 ttcctgaaga agtacctgta cgagatcgcc cggcggcacc cctacttcta cgcccccgag 600 ctgctgttct tcgccaagcg gtacaaggcc gccttcaccg agtgctgcca ggccgccgac 660 aaggccgcct gcctgctgcc caagctggac gagctgcggg acgagggcaa ggccagcagc 720 gccaagcagc ggctgaagtg cgccagcctg cagaagttcg gcgagcgggc cttcaaggcc 780 tgggccgtgg cccggctgag ccagcggttc cccaaggccg agttcgccga ggtgagcaag 840 ctggtgaccg acctgaccaa ggtgcacacc gagtgctgcc acggcgacct gctggagtgc 900 gccgacgacc gggccgacct ggccaagtac atctgcgaga accaggacag catcagcagc 960 aagctgaagg agtgctgcga gaagcccctg ctggagaaga gccactgcat cgccgaggtg 1020 gagaacgacg agatgcccgc cgacctgccc agcctggccg ccgacttcgt ggagagcaag 1080 gacgtgtgca agaactacgc cgaggccaag gacgtgttcc tgggcatgtt cctgtacgag 1140 tacgcccggc ggcaccccga ctacagcgtg gtgctgctgc tgcggctggc caagacctac 1200 gagaccaccc tggagaagtg ctgcgccgcc gccgaccccc acgagtgcta cgccaaggtg 1260 ttcgacgagt tcaagcccct ggtggaggag ccccagaacc tgatcaagca gaactgcgag 1320 ctgttcgagc agctgggcga gtacaagttc cagaacgccc tgctggtgcg gtacaccaag 1380 aaggtgcccc aggtgagcac ccccaccctg gtggaggtga gccggaacct gggcaaggtg 1440 ggcagcaagt gctgcaagca ccccgaggcc aagcggatgc cctgcgccga ggactacctg 1500 agcgtggtgc tgaaccagct gtgcgtgctg cacgagaaga cccccgtgag cgaccgggtg 1560 accaagtgct gcaccgagag cctggtgaac cggcggccct gcttcagcgc cctggaggtg 1620 gacgagacct acgtgcccaa ggagttcaac gccgagacct tcaccttcca cgccgacatc 1680 tgcaccctga gcgagaagga gcggcagatc aagaagcaga ccgccctggt ggagctggtg 1740 aagcacaagc ccaaggccac caaggagcag ctgaaggccg tgatggacga cttcgccgcc 1800 ttcgtggaga agtgctgcaa ggccgacgac aaggagacct gcttcgccga ggagggcaag 1860 aagctggtgg ccgccagcca ggccgccctg ggcctgggcg gcagcggcgg cagcggcggc 1920 agcggcggca gctgcagcgg ccccctgggc atcgagggcg gcatcatcag caaccagcag 1980 atcaccgcca gcagcaccca ccgggccctg ttcggcctgc agaagtggta cccctactac 2040 gcccggctga acaagaaggg cctgatcaac gcctggaccg ccgccgagaa cgaccggtgg 2100 ccctggatcc agatcaacct gcagcggaag atgcgggtga ccggcgtgat cacccagggc 2160 gccaagcgga tcggcagccc cgagtacatc aagagctaca agatcgccta cagcaacgac 2220 ggcaagacct gggccatgta caaggtgaag ggcaccaacg aggacatggt gttccggggc 2280 aacatcgaca acaacacccc ctacgccaac agcttcaccc cccccatcaa ggcccagtac 2340 gtgcggctgt acccccaggt gtgccggcgg cactgcaccc tgcggatgga gctgctgggc 2400 tgcgagctga gcggctgcag cgagcccctg ggcatgaaga gcggccacat ccaggactac 2460 cagatcaccg ccagcagcat cttccggacc ctgaacatgg acatgttcac ctgggagccc 2520 cggaaggccc ggctggacaa gcagggcaag gtgaacgcct ggaccagcgg ccacaacgac 2580 cagagccagt ggctgcaggt ggacctgctg gtgcccacca aggtgaccgg catcatcacc 2640 cagggcgcca aggacttcgg ccacgtgcag ttcgtgggca gctacaagct ggcctacagc 2700 aacgacggcg agcactggac cgtgtaccag gacgagaagc agcggaagga caaggtgttc 2760 cagggcaact tcgacaacga cacccaccgg aagaacgtga tcgacccccc catctacgcc 2820 cggcacatcc ggatcctgcc ctggagctgg tacggccgga tcaccctgcg gagcgagctg 2880 ctgggctgc 2889 <210> 92 <211> 2871 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 92 aacatcaacg agtgcgaggt ggagccctgc aagaacggcg gcatctgcac cgacctggtg 60 gccaactaca gctgcgagtg ccccggcgag ttcatgggcc ggaactgcca gtacaagggc 120 agcgacgccc acaagagcga ggtggcccac cggttcaagg acctgggcga ggagaacttc 180 aaggccctgg tgctgatcgc cttcgcccag tacctgcagc agagcccctt cgaggaccac 240 gtgaagctgg tgaacgaggt gaccgagttc gccaagacct gcgtggccga cgagagcgcc 300 gagaactgcg acaagagcct gcacaccctg ttcggcgaca agctgtgcac cgtggccacc 360 ctgcgggaga cctacggcga gatggccgac tgctgcgcca agcaggagcc cgagcggaac 420 gagtgcttcc tgcagcacaa ggacgacaac cccaacctgc cccggctggt gcggcccgag 480 gtggacgtga tgtgcaccgc cttccacgac aacgaggaga ccttcctgaa gaagtacctg 540 tacgagatcg cccggcggca cccctacttc tacgcccccg agctgctgtt cttcgccaag 600 cggtacaagg ccgccttcac cgagtgctgc caggccgccg acaaggccgc ctgcctgctg 660 cccaagctgg acgagctgcg ggacgagggc aaggccagca gcgccaagca gcggctgaag 720 tgcgccagcc tgcagaagtt cggcgagcgg gccttcaagg cctgggccgt ggcccggctg 780 agccagcggt tccccaaggc cgagttcgcc gaggtgagca agctggtgac cgacctgacc 840 aaggtgcaca ccgagtgctg ccacggcgac ctgctggagt gcgccgacga ccgggccgac 900 ctggccaagt acatctgcga gaaccaggac agcatcagca gcaagctgaa ggagtgctgc 960 gagaagcccc tgctggagaa gagccactgc atcgccgagg tggagaacga cgagatgccc 1020 gccgacctgc ccagcctggc cgccgacttc gtggagagca aggacgtgtg caagaactac 1080 gccgaggcca aggacgtgtt cctgggcatg ttcctgtacg agtacgcccg gcggcacccc 1140 gactacagcg tggtgctgct gctgcggctg gccaagacct acgagaccac cctggagaag 1200 tgctgcgccg ccgccgaccc ccacgagtgc tacgccaagg tgttcgacga gttcaagccc 1260 ctggtggagg agccccagaa cctgatcaag cagaactgcg agctgttcga gcagctgggc 1320 gagtacaagt tccagaacgc cctgctggtg cggtacacca agaaggtgcc ccaggtgagc 1380 acccccaccc tggtggaggt gagccggaac ctgggcaagg tgggcagcaa gtgctgcaag 1440 caccccgagg ccaagcggat gccctgcgcc gaggactacc tgagcgtggt gctgaaccag 1500 ctgtgcgtgc tgcacgagaa gacccccgtg agcgaccggg tgaccaagtg ctgcaccgag 1560 agcctggtga accggcggcc ctgcttcagc gccctggagg tggacgagac ctacgtgccc 1620 aaggagttca acgccgagac cttcaccttc cacgccgaca tctgcaccct gagcgagaag 1680 gagcggcaga tcaagaagca gaccgccctg gtggagctgg tgaagcacaa gcccaaggcc 1740 accaaggagc agctgaaggc cgtgatggac gacttcgccg ccttcgtgga gaagtgctgc 1800 aaggccgacg acaaggagac ctgcttcgcc gaggagggca agaagctggt ggccgccagc 1860 caggccgccc tgggcctggg cggcagcggc ggcagcggcg gcagcggcgg cagctgcagc 1920 ggccccctgg gcatcgaggg cggcatcatc agcaaccagc agatcaccgc cagcagcacc 1980 caccgggccc tgttcggcct gcagaagtgg tacccctact acgcccggct gaacaagaag 2040 ggcctgatca acgcctggac cgccgccgag aacgaccggt ggccctggat ccagatcaac 2100 ctgcagcgga agatgcgggt gaccggcgtg atcacccagg gcgccaagcg gatcggcagc 2160 cccgagtaca tcaagagcta caagatcgcc tacagcaacg acggcaagac ctgggccatg 2220 tacaaggtga agggcaccaa cgaggacatg gtgttccggg gcaacatcga caacaacacc 2280 ccctacgcca acagcttcac cccccccatc aaggcccagt acgtgcggct gtacccccag 2340 gtgtgccggc ggcactgcac cctgcggatg gagctgctgg gctgcgagct gagcggctgc 2400 agcgagcccc tgggcatgaa gagcggccac atccaggact accagatcac cgccagcagc 2460 atcttccgga ccctgaacat ggacatgttc acctgggagc cccggaaggc ccggctggac 2520 aagcagggca aggtgaacgc ctggaccagc ggccacaacg accagagcca gtggctgcag 2580 gtggacctgc tggtgcccac caaggtgacc ggcatcatca cccagggcgc caaggacttc 2640 ggccacgtgc agttcgtggg cagctacaag ctggcctaca gcaacgacgg cgagcactgg 2700 accgtgtacc aggacgagaa gcagcggaag gacaaggtgt tccagggcaa cttcgacaac 2760 gacacccacc ggaagaacgt gatcgacccc cccatctacg cccggcacat ccggatcctg 2820 ccctggagct ggtacggccg gatcaccctg cggagcgagc tgctgggctg c 2871 <210> 93 <211> 3039 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 93 gacatctgcg accccaaccc ctgcgagaac ggcggcatct gcctgcccgg cctggccgac 60 ggcagcttca gctgcgagtg ccccgacggc ttcaccgacc ccaactgcag cagcgtggtg 120 gaggtggcca gcgacgagga ggagcccacc agcgccggcc cctgcacccc caacccctgc 180 cacaacggcg gcacctgcga gatcagcgag gcctaccggg gcgacacctt catcggctac 240 gtgtgcaagt gcccccgggg cttcaacggc atccactgcc agcacggcag cgacgcccac 300 aagagcgagg tggcccaccg gttcaaggac ctgggcgagg agaacttcaa ggccctggtg 360 ctgatcgcct tcgcccagta cctgcagcag agccccttcg aggaccacgt gaagctggtg 420 aacgaggtga ccgagttcgc caagacctgc gtggccgacg agagcgccga gaactgcgac 480 aagagcctgc acaccctgtt cggcgacaag ctgtgcaccg tggccaccct gcgggagacc 540 tacggcgaga tggccgactg ctgcgccaag caggagcccg agcggaacga gtgcttcctg 600 cagcacaagg acgacaaccc caacctgccc cggctggtgc ggcccgaggt ggacgtgatg 660 tgcaccgcct tccacgacaa cgaggagacc ttcctgaaga agtacctgta cgagatcgcc 720 cggcggcacc cctacttcta cgcccccgag ctgctgttct tcgccaagcg gtacaaggcc 780 gccttcaccg agtgctgcca ggccgccgac aaggccgcct gcctgctgcc caagctggac 840 gagctgcggg acgagggcaa ggccagcagc gccaagcagc ggctgaagtg cgccagcctg 900 cagaagttcg gcgagcgggc cttcaaggcc tgggccgtgg cccggctgag ccagcggttc 960 cccaaggccg agttcgccga ggtgagcaag ctggtgaccg acctgaccaa ggtgcacacc 1020 gagtgctgcc acggcgacct gctggagtgc gccgacgacc gggccgacct ggccaagtac 1080 atctgcgaga accaggacag catcagcagc aagctgaagg agtgctgcga gaagcccctg 1140 ctggagaaga gccactgcat cgccgaggtg gagaacgacg agatgcccgc cgacctgccc 1200 agcctggccg ccgacttcgt ggagagcaag gacgtgtgca agaactacgc cgaggccaag 1260 gacgtgttcc tgggcatgtt cctgtacgag tacgcccggc ggcaccccga ctacagcgtg 1320 gtgctgctgc tgcggctggc caagacctac gagaccaccc tggagaagtg ctgcgccgcc 1380 gccgaccccc acgagtgcta cgccaaggtg ttcgacgagt tcaagcccct ggtggaggag 1440 ccccagaacc tgatcaagca gaactgcgag ctgttcgagc agctgggcga gtacaagttc 1500 cagaacgccc tgctggtgcg gtacaccaag aaggtgcccc aggtgagcac ccccaccctg 1560 gtggaggtga gccggaacct gggcaaggtg ggcagcaagt gctgcaagca ccccgaggcc 1620 aagcggatgc cctgcgccga ggactacctg agcgtggtgc tgaaccagct gtgcgtgctg 1680 cacgagaaga cccccgtgag cgaccgggtg accaagtgct gcaccgagag cctggtgaac 1740 cggcggccct gcttcagcgc cctggaggtg gacgagacct acgtgcccaa ggagttcaac 1800 gccgagacct tcaccttcca cgccgacatc tgcaccctga gcgagaagga gcggcagatc 1860 aagaagcaga ccgccctggt ggagctggtg aagcacaagc ccaaggccac caaggagcag 1920 ctgaaggccg tgatggacga cttcgccgcc ttcgtggaga agtgctgcaa ggccgacgac 1980 aaggagacct gcttcgccga ggagggcaag aagctggtgg ccgccagcca ggccgccctg 2040 ggcctgggcg gcagcggcgg cagcggcggc agcggcggca gctgcagcgg ccccctgggc 2100 atcgagggcg gcatcatcag caaccagcag atcaccgcca gcagcaccca ccgggccctg 2160 ttcggcctgc agaagtggta cccctactac gcccggctga acaagaaggg cctgatcaac 2220 gcctggaccg ccgccgagaa cgaccggtgg ccctggatcc agatcaacct gcagcggaag 2280 atgcgggtga ccggcgtgat cacccagggc gccaagcgga tcggcagccc cgagtacatc 2340 aagagctaca agatcgccta cagcaacgac ggcaagacct gggccatgta caaggtgaag 2400 ggcaccaacg aggacatggt gttccggggc aacatcgaca acaacacccc ctacgccaac 2460 agcttcaccc cccccatcaa ggcccagtac gtgcggctgt acccccaggt gtgccggcgg 2520 cactgcaccc tgcggatgga gctgctgggc tgcgagctga gcggctgcag cgagcccctg 2580 ggcatgaaga gcggccacat ccaggactac cagatcaccg ccagcagcat cttccggacc 2640 ctgaacatgg acatgttcac ctgggagccc cggaaggccc ggctggacaa gcagggcaag 2700 gtgaacgcct ggaccagcgg ccacaacgac cagagccagt ggctgcaggt ggacctgctg 2760 gtgcccacca aggtgaccgg catcatcacc cagggcgcca aggacttcgg ccacgtgcag 2820 ttcgtgggca gctacaagct ggcctacagc aacgacggcg agcactggac cgtgtaccag 2880 gacgagaagc agcggaagga caaggtgttc cagggcaact tcgacaacga cacccaccgg 2940 aagaacgtga tcgacccccc catctacgcc cggcacatcc ggatcctgcc ctggagctgg 3000 tacggccgga tcaccctgcg gagcgagctg ctgggctgc 3039 <210> 94 <211> 3006 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 94 agcgccggcc cctgcacccc caacccctgc cacaacggcg gcacctgcga gatcagcgag 60 gcctaccggg gcgacacctt catcggctac gtgtgcaagt gcccccgggg cttcaacggc 120 atccactgcc agcacaacat caacgagtgc gaggtggagc cctgcaagaa cggcggcatc 180 tgcaccgacc tggtggccaa ctacagctgc gagtgccccg gcgagttcat gggccggaac 240 tgccagtaca agggcagcga cgcccacaag agcgaggtgg cccaccggtt caaggacctg 300 ggcgaggaga acttcaaggc cctggtgctg atcgccttcg cccagtacct gcagcagagc 360 cccttcgagg accacgtgaa gctggtgaac gaggtgaccg agttcgccaa gacctgcgtg 420 gccgacgaga gcgccgagaa ctgcgacaag agcctgcaca ccctgttcgg cgacaagctg 480 tgcaccgtgg ccaccctgcg ggagacctac ggcgagatgg ccgactgctg cgccaagcag 540 gagcccgagc ggaacgagtg cttcctgcag cacaaggacg acaaccccaa cctgccccgg 600 ctggtgcggc ccgaggtgga cgtgatgtgc accgccttcc acgacaacga ggagaccttc 660 ctgaagaagt acctgtacga gatcgcccgg cggcacccct acttctacgc ccccgagctg 720 ctgttcttcg ccaagcggta caaggccgcc ttcaccgagt gctgccaggc cgccgacaag 780 gccgcctgcc tgctgcccaa gctggacgag ctgcgggacg agggcaaggc cagcagcgcc 840 aagcagcggc tgaagtgcgc cagcctgcag aagttcggcg agcgggcctt caaggcctgg 900 gccgtggccc ggctgagcca gcggttcccc aaggccgagt tcgccgaggt gagcaagctg 960 gtgaccgacc tgaccaaggt gcacaccgag tgctgccacg gcgacctgct ggagtgcgcc 1020 gacgaccggg ccgacctggc caagtacatc tgcgagaacc aggacagcat cagcagcaag 1080 ctgaaggagt gctgcgagaa gcccctgctg gagaagagcc actgcatcgc cgaggtggag 1140 aacgacgaga tgcccgccga cctgcccagc ctggccgccg acttcgtgga gagcaaggac 1200 gtgtgcaaga actacgccga ggccaaggac gtgttcctgg gcatgttcct gtacgagtac 1260 gcccggcggc accccgacta cagcgtggtg ctgctgctgc ggctggccaa gacctacgag 1320 accaccctgg agaagtgctg cgccgccgcc gacccccacg agtgctacgc caaggtgttc 1380 gacgagttca agcccctggt ggaggagccc cagaacctga tcaagcagaa ctgcgagctg 1440 ttcgagcagc tgggcgagta caagttccag aacgccctgc tggtgcggta caccaagaag 1500 gtgccccagg tgagcacccc caccctggtg gaggtgagcc ggaacctggg caaggtgggc 1560 agcaagtgct gcaagcaccc cgaggccaag cggatgccct gcgccgagga ctacctgagc 1620 gtggtgctga accagctgtg cgtgctgcac gagaagaccc ccgtgagcga ccgggtgacc 1680 aagtgctgca ccgagagcct ggtgaaccgg cggccctgct tcagcgccct ggaggtggac 1740 gagacctacg tgcccaagga gttcaacgcc gagaccttca ccttccacgc cgacatctgc 1800 accctgagcg agaaggagcg gcagatcaag aagcagaccg ccctggtgga gctggtgaag 1860 cacaagccca aggccaccaa ggagcagctg aaggccgtga tggacgactt cgccgccttc 1920 gtggagaagt gctgcaaggc cgacgacaag gagacctgct tcgccgagga gggcaagaag 1980 ctggtggccg ccagccaggc cgccctgggc ctgggcggca gcggcggcag cggcggcagc 2040 ggcggcagct gcagcggccc cctgggcatc gagggcggca tcatcagcaa ccagcagatc 2100 accgccagca gcacccaccg ggccctgttc ggcctgcaga agtggtaccc ctactacgcc 2160 cggctgaaca agaagggcct gatcaacgcc tggaccgccg ccgagaacga ccggtggccc 2220 tggatccaga tcaacctgca gcggaagatg cgggtgaccg gcgtgatcac ccagggcgcc 2280 aagcggatcg gcagccccga gtacatcaag agctacaaga tcgcctacag caacgacggc 2340 aagacctggg ccatgtacaa ggtgaagggc accaacgagg acatggtgtt ccggggcaac 2400 atcgacaaca acacccccta cgccaacagc ttcacccccc ccatcaaggc ccagtacgtg 2460 cggctgtacc cccaggtgtg ccggcggcac tgcaccctgc ggatggagct gctgggctgc 2520 gagctgagcg gctgcagcga gcccctgggc atgaagagcg gccacatcca ggactaccag 2580 atcaccgcca gcagcatctt ccggaccctg aacatggaca tgttcacctg ggagccccgg 2640 aaggcccggc tggacaagca gggcaaggtg aacgcctgga ccagcggcca caacgaccag 2700 agccagtggc tgcaggtgga cctgctggtg cccaccaagg tgaccggcat catcacccag 2760 ggcgccaagg acttcggcca cgtgcagttc gtgggcagct acaagctggc ctacagcaac 2820 gacggcgagc actggaccgt gtaccaggac gagaagcagc ggaaggacaa ggtgttccag 2880 ggcaacttcg acaacgacac ccaccggaag aacgtgatcg acccccccat ctacgcccgg 2940 cacatccgga tcctgccctg gagctggtac ggccggatca ccctgcggag cgagctgctg 3000 ggctgc 3006 <210> 95 <211> 3021 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 95 gacatctgcg accccaaccc ctgcgagaac ggcggcatct gcctgcccgg cctggccgac 60 ggcagcttca gctgcgagtg ccccgacggc ttcaccgacc ccaactgcag cagcgtggtg 120 gaggtggcca gcgacgagga ggagcccacc aacatcaacg agtgcgaggt ggagccctgc 180 aagaacggcg gcatctgcac cgacctggtg gccaactaca gctgcgagtg ccccggcgag 240 ttcatgggcc ggaactgcca gtacaagggc agcgacgccc acaagagcga ggtggcccac 300 cggttcaagg acctgggcga ggagaacttc aaggccctgg tgctgatcgc cttcgcccag 360 tacctgcagc agagcccctt cgaggaccac gtgaagctgg tgaacgaggt gaccgagttc 420 gccaagacct gcgtggccga cgagagcgcc gagaactgcg acaagagcct gcacaccctg 480 ttcggcgaca agctgtgcac cgtggccacc ctgcgggaga cctacggcga gatggccgac 540 tgctgcgcca agcaggagcc cgagcggaac gagtgcttcc tgcagcacaa ggacgacaac 600 cccaacctgc cccggctggt gcggcccgag gtggacgtga tgtgcaccgc cttccacgac 660 aacgaggaga ccttcctgaa gaagtacctg tacgagatcg cccggcggca cccctacttc 720 tacgcccccg agctgctgtt cttcgccaag cggtacaagg ccgccttcac cgagtgctgc 780 caggccgccg acaaggccgc ctgcctgctg cccaagctgg acgagctgcg ggacgagggc 840 aaggccagca gcgccaagca gcggctgaag tgcgccagcc tgcagaagtt cggcgagcgg 900 gccttcaagg cctgggccgt ggcccggctg agccagcggt tccccaaggc cgagttcgcc 960 gaggtgagca agctggtgac cgacctgacc aaggtgcaca ccgagtgctg ccacggcgac 1020 ctgctggagt gcgccgacga ccgggccgac ctggccaagt acatctgcga gaaccaggac 1080 agcatcagca gcaagctgaa ggagtgctgc gagaagcccc tgctggagaa gagccactgc 1140 atcgccgagg tggagaacga cgagatgccc gccgacctgc ccagcctggc cgccgacttc 1200 gtggagagca aggacgtgtg caagaactac gccgaggcca aggacgtgtt cctgggcatg 1260 ttcctgtacg agtacgcccg gcggcacccc gactacagcg tggtgctgct gctgcggctg 1320 gccaagacct acgagaccac cctggagaag tgctgcgccg ccgccgaccc ccacgagtgc 1380 tacgccaagg tgttcgacga gttcaagccc ctggtggagg agccccagaa cctgatcaag 1440 cagaactgcg agctgttcga gcagctgggc gagtacaagt tccagaacgc cctgctggtg 1500 cggtacacca agaaggtgcc ccaggtgagc acccccaccc tggtggaggt gagccggaac 1560 ctgggcaagg tgggcagcaa gtgctgcaag caccccgagg ccaagcggat gccctgcgcc 1620 gaggactacc tgagcgtggt gctgaaccag ctgtgcgtgc tgcacgagaa gacccccgtg 1680 agcgaccggg tgaccaagtg ctgcaccgag agcctggtga accggcggcc ctgcttcagc 1740 gccctggagg tggacgagac ctacgtgccc aaggagttca acgccgagac cttcaccttc 1800 cacgccgaca tctgcaccct gagcgagaag gagcggcaga tcaagaagca gaccgccctg 1860 gtggagctgg tgaagcacaa gcccaaggcc accaaggagc agctgaaggc cgtgatggac 1920 gacttcgccg ccttcgtgga gaagtgctgc aaggccgacg acaaggagac ctgcttcgcc 1980 gaggagggca agaagctggt ggccgccagc caggccgccc tgggcctggg cggcagcggc 2040 ggcagcggcg gcagcggcgg cagctgcagc ggccccctgg gcatcgaggg cggcatcatc 2100 agcaaccagc agatcaccgc cagcagcacc caccgggccc tgttcggcct gcagaagtgg 2160 tacccctact acgcccggct gaacaagaag ggcctgatca acgcctggac cgccgccgag 2220 aacgaccggt ggccctggat ccagatcaac ctgcagcgga agatgcgggt gaccggcgtg 2280 atcacccagg gcgccaagcg gatcggcagc cccgagtaca tcaagagcta caagatcgcc 2340 tacagcaacg acggcaagac ctgggccatg tacaaggtga agggcaccaa cgaggacatg 2400 gtgttccggg gcaacatcga caacaacacc ccctacgcca acagcttcac cccccccatc 2460 aaggcccagt acgtgcggct gtacccccag gtgtgccggc ggcactgcac cctgcggatg 2520 gagctgctgg gctgcgagct gagcggctgc agcgagcccc tgggcatgaa gagcggccac 2580 atccaggact accagatcac cgccagcagc atcttccgga ccctgaacat ggacatgttc 2640 acctgggagc cccggaaggc ccggctggac aagcagggca aggtgaacgc ctggaccagc 2700 ggccacaacg accagagcca gtggctgcag gtggacctgc tggtgcccac caaggtgacc 2760 ggcatcatca cccagggcgc caaggacttc ggccacgtgc agttcgtggg cagctacaag 2820 ctggcctaca gcaacgacgg cgagcactgg accgtgtacc aggacgagaa gcagcggaag 2880 gacaaggtgt tccagggcaa cttcgacaac gacacccacc ggaagaacgt gatcgacccc 2940 cccatctacg cccggcacat ccggatcctg ccctggagct ggtacggccg gatcaccctg 3000 cggagcgagc tgctgggctg c 3021 <210> 96 <211> 50 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 96 Asp Ile Cys Asp Pro Asn Pro Cys Glu Asn Gly Gly Ile Cys Leu Pro 1 5 10 15 Gly Leu Ala Asp Gly Ser Phe Ser Cys Glu Cys Pro Asp Gly Phe Thr 20 25 30 Asp Pro Asn Cys Ser Ser Val Val Glu Val Ala Ser Asp Glu Glu Glu 35 40 45 Pro Thr 50 <210> 97 <211> 45 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 97 Ser Ala Gly Pro Cys Thr Pro Asn Pro Cys His Asn Gly Gly Thr Cys 1 5 10 15 Glu Ile Ser Glu Ala Tyr Arg Gly Asp Thr Phe Ile Gly Tyr Val Cys 20 25 30 Lys Cys Pro Arg Gly Phe Asn Gly Ile His Cys Gln His 35 40 45 <210> 98 <211> 39 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 98 Asn Ile Asn Glu Cys Glu Val Glu Pro Cys Lys Asn Gly Gly Ile Cys 1 5 10 15 Thr Asp Leu Val Ala Asn Tyr Ser Cys Glu Cys Pro Gly Glu Phe Met 20 25 30 Gly Arg Asn Cys Gln Tyr Lys 35 <210> 99 <211> 95 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 99 Asp Ile Cys Asp Pro Asn Pro Cys Glu Asn Gly Gly Ile Cys Leu Pro 1 5 10 15 Gly Leu Ala Asp Gly Ser Phe Ser Cys Glu Cys Pro Asp Gly Phe Thr 20 25 30 Asp Pro Asn Cys Ser Ser Val Val Glu Val Ala Ser Asp Glu Glu Glu 35 40 45 Pro Thr Ser Ala Gly Pro Cys Thr Pro Asn Pro Cys His Asn Gly Gly 50 55 60 Thr Cys Glu Ile Ser Glu Ala Tyr Arg Gly Asp Thr Phe Ile Gly Tyr 65 70 75 80 Val Cys Lys Cys Pro Arg Gly Phe Asn Gly Ile His Cys Gln His 85 90 95 <210> 100 <211> 84 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 100 Ser Ala Gly Pro Cys Thr Pro Asn Pro Cys His Asn Gly Gly Thr Cys 1 5 10 15 Glu Ile Ser Glu Ala Tyr Arg Gly Asp Thr Phe Ile Gly Tyr Val Cys 20 25 30 Lys Cys Pro Arg Gly Phe Asn Gly Ile His Cys Gln His Asn Ile Asn 35 40 45 Glu Cys Glu Val Glu Pro Cys Lys Asn Gly Gly Ile Cys Thr Asp Leu 50 55 60 Val Ala Asn Tyr Ser Cys Glu Cys Pro Gly Glu Phe Met Gly Arg Asn 65 70 75 80 Cys Gln Tyr Lys <210> 101 <211> 89 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 101 Asp Ile Cys Asp Pro Asn Pro Cys Glu Asn Gly Gly Ile Cys Leu Pro 1 5 10 15 Gly Leu Ala Asp Gly Ser Phe Ser Cys Glu Cys Pro Asp Gly Phe Thr 20 25 30 Asp Pro Asn Cys Ser Ser Val Val Glu Val Ala Ser Asp Glu Glu Glu 35 40 45 Pro Thr Asn Ile Asn Glu Cys Glu Val Glu Pro Cys Lys Asn Gly Gly 50 55 60 Ile Cys Thr Asp Leu Val Ala Asn Tyr Ser Cys Glu Cys Pro Gly Glu 65 70 75 80 Phe Met Gly Arg Asn Cys Gln Tyr Lys 85 <210> 102 <211> 945 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 102 Asp Ile Cys Asp Pro Asn Pro Cys Glu Asn Gly Gly Ile Cys Leu Pro 1 5 10 15 Gly Leu Ala Asp Gly Ser Phe Ser Cys Glu Cys Pro Asp Gly Phe Thr 20 25 30 Asp Pro Asn Cys Ser Ser Val Val Glu Val Ala Ser Asp Glu Glu Glu 35 40 45 Pro Thr Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu 50 55 60 Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr 65 70 75 80 Leu Gln Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val 85 90 95 Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys 100 105 110 Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala 115 120 125 Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln 130 135 140 Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro 145 150 155 160 Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala 165 170 175 Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile 180 185 190 Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala 195 200 205 Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys 210 215 220 Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys 225 230 235 240 Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe 245 250 255 Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg 260 265 270 Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu 275 280 285 Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala 290 295 300 Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser 305 310 315 320 Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys 325 330 335 Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu 340 345 350 Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn 355 360 365 Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr 370 375 380 Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala 385 390 395 400 Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro 405 410 415 His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu 420 425 430 Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu 435 440 445 Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys 450 455 460 Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu 465 470 475 480 Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met 485 490 495 Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val 500 505 510 Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr 515 520 525 Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp 530 535 540 Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His 545 550 555 560 Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln 565 570 575 Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu 580 585 590 Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys 595 600 605 Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys 610 615 620 Leu Val Ala Cys Val Glu Pro Leu Gly Met Glu Asn Gly Asn Ile Ala 625 630 635 640 Asn Ser Gln Ile Ala Ala Ser Ser Val Arg Val Thr Phe Leu Gly Leu 645 650 655 Gln His Trp Val Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly Met Val 660 665 670 Asn Ala Trp Thr Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile Gln Val 675 680 685 Asn Leu Leu Arg Arg Met Trp Val Thr Gly Val Val Thr Gln Gly Ala 690 695 700 Ser Arg Leu Ala Ser His Glu Tyr Leu Lys Ala Phe Lys Val Ala Tyr 705 710 715 720 Ser Leu Asn Gly His Glu Phe Asp Phe Ile His Asp Val Asn Lys Lys 725 730 735 His Lys Glu Phe Val Gly Asn Trp Asn Lys Asn Ala Val His Val Asn 740 745 750 Leu Phe Glu Thr Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr Pro Thr 755 760 765 Ser Cys His Thr Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly Cys Glu 770 775 780 Leu Asn Gly Cys Ala Asn Pro Leu Gly Leu Lys Asn Asn Ser Ile Pro 785 790 795 800 Asp Lys Gln Ile Thr Ala Ser Ser Ser Tyr Lys Thr Trp Gly Leu His 805 810 815 Leu Phe Ser Trp Asn Pro Ser Tyr Ala Arg Leu Asp Lys Gln Gly Asn 820 825 830 Phe Asn Ala Trp Val Ala Gly Ser Tyr Gly Asn Asp Gln Trp Leu Gln 835 840 845 Val Asp Leu Gly Ser Ser Lys Glu Val Thr Gly Ile Ile Thr Gln Gly 850 855 860 Ala Arg Asn Phe Gly Ser Val Gln Phe Val Ala Ser Tyr Lys Val Ala 865 870 875 880 Tyr Ser Asn Asp Ser Ala Asn Trp Thr Glu Tyr Gln Asp Pro Arg Thr 885 890 895 Gly Ser Ser Lys Ile Phe Pro Gly Asn Trp Asp Asn His Ser His Lys 900 905 910 Lys Asn Leu Phe Glu Thr Pro Ile Leu Ala Arg Tyr Val Arg Ile Leu 915 920 925 Pro Val Ala Trp His Asn Arg Ile Ala Leu Arg Leu Glu Leu Leu Gly 930 935 940 Cys 945 <210> 103 <211> 940 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 103 Ser Ala Gly Pro Cys Thr Pro Asn Pro Cys His Asn Gly Gly Thr Cys 1 5 10 15 Glu Ile Ser Glu Ala Tyr Arg Gly Asp Thr Phe Ile Gly Tyr Val Cys 20 25 30 Lys Cys Pro Arg Gly Phe Asn Gly Ile His Cys Gln His Asp Ala His 35 40 45 Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe 50 55 60 Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Ser Pro 65 70 75 80 Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys 85 90 95 Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His 100 105 110 Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr 115 120 125 Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn 130 135 140 Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu 145 150 155 160 Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu 165 170 175 Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro 180 185 190 Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala 195 200 205 Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu 210 215 220 Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys 225 230 235 240 Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe 245 250 255 Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu 260 265 270 Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr 275 280 285 Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp 290 295 300 Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu 305 310 315 320 Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala 325 330 335 Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala 340 345 350 Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys 355 360 365 Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro 370 375 380 Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr 385 390 395 400 Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala 405 410 415 Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu 420 425 430 Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe 435 440 445 Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser 450 455 460 Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser 465 470 475 480 Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp 485 490 495 Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr 500 505 510 Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn 515 520 525 Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro 530 535 540 Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr 545 550 555 560 Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu 565 570 575 Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val 580 585 590 Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp 595 600 605 Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Cys Val 610 615 620 Glu Pro Leu Gly Met Glu Asn Gly Asn Ile Ala Asn Ser Gln Ile Ala 625 630 635 640 Ala Ser Ser Val Arg Val Thr Phe Leu Gly Leu Gln His Trp Val Pro 645 650 655 Glu Leu Ala Arg Leu Asn Arg Ala Gly Met Val Asn Ala Trp Thr Pro 660 665 670 Ser Ser Asn Asp Asp Asn Pro Trp Ile Gln Val Asn Leu Leu Arg Arg 675 680 685 Met Trp Val Thr Gly Val Val Thr Gln Gly Ala Ser Arg Leu Ala Ser 690 695 700 His Glu Tyr Leu Lys Ala Phe Lys Val Ala Tyr Ser Leu Asn Gly His 705 710 715 720 Glu Phe Asp Phe Ile His Asp Val Asn Lys Lys His Lys Glu Phe Val 725 730 735 Gly Asn Trp Asn Lys Asn Ala Val His Val Asn Leu Phe Glu Thr Pro 740 745 750 Val Glu Ala Gln Tyr Val Arg Leu Tyr Pro Thr Ser Cys His Thr Ala 755 760 765 Cys Thr Leu Arg Phe Glu Leu Leu Gly Cys Glu Leu Asn Gly Cys Ala 770 775 780 Asn Pro Leu Gly Leu Lys Asn Asn Ser Ile Pro Asp Lys Gln Ile Thr 785 790 795 800 Ala Ser Ser Ser Tyr Lys Thr Trp Gly Leu His Leu Phe Ser Trp Asn 805 810 815 Pro Ser Tyr Ala Arg Leu Asp Lys Gln Gly Asn Phe Asn Ala Trp Val 820 825 830 Ala Gly Ser Tyr Gly Asn Asp Gln Trp Leu Gln Val Asp Leu Gly Ser 835 840 845 Ser Lys Glu Val Thr Gly Ile Ile Thr Gln Gly Ala Arg Asn Phe Gly 850 855 860 Ser Val Gln Phe Val Ala Ser Tyr Lys Val Ala Tyr Ser Asn Asp Ser 865 870 875 880 Ala Asn Trp Thr Glu Tyr Gln Asp Pro Arg Thr Gly Ser Ser Lys Ile 885 890 895 Phe Pro Gly Asn Trp Asp Asn His Ser His Lys Lys Asn Leu Phe Glu 900 905 910 Thr Pro Ile Leu Ala Arg Tyr Val Arg Ile Leu Pro Val Ala Trp His 915 920 925 Asn Arg Ile Ala Leu Arg Leu Glu Leu Leu Gly Cys 930 935 940 <210> 104 <211> 934 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 104 Asn Ile Asn Glu Cys Glu Val Glu Pro Cys Lys Asn Gly Gly Ile Cys 1 5 10 15 Thr Asp Leu Val Ala Asn Tyr Ser Cys Glu Cys Pro Gly Glu Phe Met 20 25 30 Gly Arg Asn Cys Gln Tyr Lys Asp Ala His Lys Ser Glu Val Ala His 35 40 45 Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile 50 55 60 Ala Phe Ala Gln Tyr Leu Gln Gln Ser Pro Phe Glu Asp His Val Lys 65 70 75 80 Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu 85 90 95 Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys 100 105 110 Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp 115 120 125 Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His 130 135 140 Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp 145 150 155 160 Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys 165 170 175 Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu 180 185 190 Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys 195 200 205 Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu 210 215 220 Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala 225 230 235 240 Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala 245 250 255 Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys 260 265 270 Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp 275 280 285 Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys 290 295 300 Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys 305 310 315 320 Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu 325 330 335 Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys 340 345 350 Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met 355 360 365 Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu 370 375 380 Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys 385 390 395 400 Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe 405 410 415 Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu 420 425 430 Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val 435 440 445 Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu 450 455 460 Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro 465 470 475 480 Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu 485 490 495 Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val 500 505 510 Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser 515 520 525 Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu 530 535 540 Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg 545 550 555 560 Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro 565 570 575 Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala 580 585 590 Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala 595 600 605 Glu Glu Gly Lys Lys Leu Val Ala Cys Val Glu Pro Leu Gly Met Glu 610 615 620 Asn Gly Asn Ile Ala Asn Ser Gln Ile Ala Ala Ser Ser Val Arg Val 625 630 635 640 Thr Phe Leu Gly Leu Gln His Trp Val Pro Glu Leu Ala Arg Leu Asn 645 650 655 Arg Ala Gly Met Val Asn Ala Trp Thr Pro Ser Ser Asn Asp Asp Asn 660 665 670 Pro Trp Ile Gln Val Asn Leu Leu Arg Arg Met Trp Val Thr Gly Val 675 680 685 Val Thr Gln Gly Ala Ser Arg Leu Ala Ser His Glu Tyr Leu Lys Ala 690 695 700 Phe Lys Val Ala Tyr Ser Leu Asn Gly His Glu Phe Asp Phe Ile His 705 710 715 720 Asp Val Asn Lys Lys His Lys Glu Phe Val Gly Asn Trp Asn Lys Asn 725 730 735 Ala Val His Val Asn Leu Phe Glu Thr Pro Val Glu Ala Gln Tyr Val 740 745 750 Arg Leu Tyr Pro Thr Ser Cys His Thr Ala Cys Thr Leu Arg Phe Glu 755 760 765 Leu Leu Gly Cys Glu Leu Asn Gly Cys Ala Asn Pro Leu Gly Leu Lys 770 775 780 Asn Asn Ser Ile Pro Asp Lys Gln Ile Thr Ala Ser Ser Ser Tyr Lys 785 790 795 800 Thr Trp Gly Leu His Leu Phe Ser Trp Asn Pro Ser Tyr Ala Arg Leu 805 810 815 Asp Lys Gln Gly Asn Phe Asn Ala Trp Val Ala Gly Ser Tyr Gly Asn 820 825 830 Asp Gln Trp Leu Gln Val Asp Leu Gly Ser Ser Lys Glu Val Thr Gly 835 840 845 Ile Ile Thr Gln Gly Ala Arg Asn Phe Gly Ser Val Gln Phe Val Ala 850 855 860 Ser Tyr Lys Val Ala Tyr Ser Asn Asp Ser Ala Asn Trp Thr Glu Tyr 865 870 875 880 Gln Asp Pro Arg Thr Gly Ser Ser Lys Ile Phe Pro Gly Asn Trp Asp 885 890 895 Asn His Ser His Lys Lys Asn Leu Phe Glu Thr Pro Ile Leu Ala Arg 900 905 910 Tyr Val Arg Ile Leu Pro Val Ala Trp His Asn Arg Ile Ala Leu Arg 915 920 925 Leu Glu Leu Leu Gly Cys 930 <210> 105 <211> 990 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 105 Asp Ile Cys Asp Pro Asn Pro Cys Glu Asn Gly Gly Ile Cys Leu Pro 1 5 10 15 Gly Leu Ala Asp Gly Ser Phe Ser Cys Glu Cys Pro Asp Gly Phe Thr 20 25 30 Asp Pro Asn Cys Ser Ser Val Val Glu Val Ala Ser Asp Glu Glu Glu 35 40 45 Pro Thr Ser Ala Gly Pro Cys Thr Pro Asn Pro Cys His Asn Gly Gly 50 55 60 Thr Cys Glu Ile Ser Glu Ala Tyr Arg Gly Asp Thr Phe Ile Gly Tyr 65 70 75 80 Val Cys Lys Cys Pro Arg Gly Phe Asn Gly Ile His Cys Gln His Asp 85 90 95 Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu 100 105 110 Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln 115 120 125 Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe 130 135 140 Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser 145 150 155 160 Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg 165 170 175 Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu 180 185 190 Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro 195 200 205 Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp 210 215 220 Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg 225 230 235 240 His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr 245 250 255 Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys 260 265 270 Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser 275 280 285 Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg 290 295 300 Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys 305 310 315 320 Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val 325 330 335 His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg 340 345 350 Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser 355 360 365 Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys 370 375 380 Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu 385 390 395 400 Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu 405 410 415 Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg 420 425 430 His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr 435 440 445 Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys 450 455 460 Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln 465 470 475 480 Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr 485 490 495 Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln 500 505 510 Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val 515 520 525 Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala 530 535 540 Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu 545 550 555 560 Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu 565 570 575 Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr 580 585 590 Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile 595 600 605 Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu 610 615 620 Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys 625 630 635 640 Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala 645 650 655 Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala 660 665 670 Cys Val Glu Pro Leu Gly Met Glu Asn Gly Asn Ile Ala Asn Ser Gln 675 680 685 Ile Ala Ala Ser Ser Val Arg Val Thr Phe Leu Gly Leu Gln His Trp 690 695 700 Val Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly Met Val Asn Ala Trp 705 710 715 720 Thr Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile Gln Val Asn Leu Leu 725 730 735 Arg Arg Met Trp Val Thr Gly Val Val Thr Gln Gly Ala Ser Arg Leu 740 745 750 Ala Ser His Glu Tyr Leu Lys Ala Phe Lys Val Ala Tyr Ser Leu Asn 755 760 765 Gly His Glu Phe Asp Phe Ile His Asp Val Asn Lys Lys His Lys Glu 770 775 780 Phe Val Gly Asn Trp Asn Lys Asn Ala Val His Val Asn Leu Phe Glu 785 790 795 800 Thr Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr Pro Thr Ser Cys His 805 810 815 Thr Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly Cys Glu Leu Asn Gly 820 825 830 Cys Ala Asn Pro Leu Gly Leu Lys Asn Asn Ser Ile Pro Asp Lys Gln 835 840 845 Ile Thr Ala Ser Ser Ser Tyr Lys Thr Trp Gly Leu His Leu Phe Ser 850 855 860 Trp Asn Pro Ser Tyr Ala Arg Leu Asp Lys Gln Gly Asn Phe Asn Ala 865 870 875 880 Trp Val Ala Gly Ser Tyr Gly Asn Asp Gln Trp Leu Gln Val Asp Leu 885 890 895 Gly Ser Ser Lys Glu Val Thr Gly Ile Ile Thr Gln Gly Ala Arg Asn 900 905 910 Phe Gly Ser Val Gln Phe Val Ala Ser Tyr Lys Val Ala Tyr Ser Asn 915 920 925 Asp Ser Ala Asn Trp Thr Glu Tyr Gln Asp Pro Arg Thr Gly Ser Ser 930 935 940 Lys Ile Phe Pro Gly Asn Trp Asp Asn His Ser His Lys Lys Asn Leu 945 950 955 960 Phe Glu Thr Pro Ile Leu Ala Arg Tyr Val Arg Ile Leu Pro Val Ala 965 970 975 Trp His Asn Arg Ile Ala Leu Arg Leu Glu Leu Leu Gly Cys 980 985 990 <210> 106 <211> 979 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 106 Ser Ala Gly Pro Cys Thr Pro Asn Pro Cys His Asn Gly Gly Thr Cys 1 5 10 15 Glu Ile Ser Glu Ala Tyr Arg Gly Asp Thr Phe Ile Gly Tyr Val Cys 20 25 30 Lys Cys Pro Arg Gly Phe Asn Gly Ile His Cys Gln His Asn Ile Asn 35 40 45 Glu Cys Glu Val Glu Pro Cys Lys Asn Gly Gly Ile Cys Thr Asp Leu 50 55 60 Val Ala Asn Tyr Ser Cys Glu Cys Pro Gly Glu Phe Met Gly Arg Asn 65 70 75 80 Cys Gln Tyr Lys Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys 85 90 95 Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala 100 105 110 Gln Tyr Leu Gln Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn 115 120 125 Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu 130 135 140 Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr 145 150 155 160 Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala 165 170 175 Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp 180 185 190 Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys 195 200 205 Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr 210 215 220 Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe 225 230 235 240 Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala 245 250 255 Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu 260 265 270 Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln 275 280 285 Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser 290 295 300 Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr 305 310 315 320 Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu 325 330 335 Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln 340 345 350 Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu 355 360 365 Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala 370 375 380 Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys 385 390 395 400 Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr 405 410 415 Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg 420 425 430 Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala 435 440 445 Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu 450 455 460 Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu 465 470 475 480 Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr 485 490 495 Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg 500 505 510 Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys 515 520 525 Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu 530 535 540 Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys 545 550 555 560 Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu 565 570 575 Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr 580 585 590 Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys 595 600 605 Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr 610 615 620 Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu 625 630 635 640 Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly 645 650 655 Lys Lys Leu Val Ala Cys Val Glu Pro Leu Gly Met Glu Asn Gly Asn 660 665 670 Ile Ala Asn Ser Gln Ile Ala Ala Ser Ser Val Arg Val Thr Phe Leu 675 680 685 Gly Leu Gln His Trp Val Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly 690 695 700 Met Val Asn Ala Trp Thr Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile 705 710 715 720 Gln Val Asn Leu Leu Arg Arg Met Trp Val Thr Gly Val Val Thr Gln 725 730 735 Gly Ala Ser Arg Leu Ala Ser His Glu Tyr Leu Lys Ala Phe Lys Val 740 745 750 Ala Tyr Ser Leu Asn Gly His Glu Phe Asp Phe Ile His Asp Val Asn 755 760 765 Lys Lys His Lys Glu Phe Val Gly Asn Trp Asn Lys Asn Ala Val His 770 775 780 Val Asn Leu Phe Glu Thr Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr 785 790 795 800 Pro Thr Ser Cys His Thr Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly 805 810 815 Cys Glu Leu Asn Gly Cys Ala Asn Pro Leu Gly Leu Lys Asn Asn Ser 820 825 830 Ile Pro Asp Lys Gln Ile Thr Ala Ser Ser Ser Tyr Lys Thr Trp Gly 835 840 845 Leu His Leu Phe Ser Trp Asn Pro Ser Tyr Ala Arg Leu Asp Lys Gln 850 855 860 Gly Asn Phe Asn Ala Trp Val Ala Gly Ser Tyr Gly Asn Asp Gln Trp 865 870 875 880 Leu Gln Val Asp Leu Gly Ser Ser Lys Glu Val Thr Gly Ile Ile Thr 885 890 895 Gln Gly Ala Arg Asn Phe Gly Ser Val Gln Phe Val Ala Ser Tyr Lys 900 905 910 Val Ala Tyr Ser Asn Asp Ser Ala Asn Trp Thr Glu Tyr Gln Asp Pro 915 920 925 Arg Thr Gly Ser Ser Lys Ile Phe Pro Gly Asn Trp Asp Asn His Ser 930 935 940 His Lys Lys Asn Leu Phe Glu Thr Pro Ile Leu Ala Arg Tyr Val Arg 945 950 955 960 Ile Leu Pro Val Ala Trp His Asn Arg Ile Ala Leu Arg Leu Glu Leu 965 970 975 Leu Gly Cys <210> 107 <211> 984 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 107 Asp Ile Cys Asp Pro Asn Pro Cys Glu Asn Gly Gly Ile Cys Leu Pro 1 5 10 15 Gly Leu Ala Asp Gly Ser Phe Ser Cys Glu Cys Pro Asp Gly Phe Thr 20 25 30 Asp Pro Asn Cys Ser Ser Val Val Glu Val Ala Ser Asp Glu Glu Glu 35 40 45 Pro Thr Asn Ile Asn Glu Cys Glu Val Glu Pro Cys Lys Asn Gly Gly 50 55 60 Ile Cys Thr Asp Leu Val Ala Asn Tyr Ser Cys Glu Cys Pro Gly Glu 65 70 75 80 Phe Met Gly Arg Asn Cys Gln Tyr Lys Asp Ala His Lys Ser Glu Val 85 90 95 Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val 100 105 110 Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Ser Pro Phe Glu Asp His 115 120 125 Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala 130 135 140 Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly 145 150 155 160 Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met 165 170 175 Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu 180 185 190 Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu 195 200 205 Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu 210 215 220 Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala 225 230 235 240 Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu 245 250 255 Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp 260 265 270 Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys 275 280 285 Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala 290 295 300 Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val 305 310 315 320 Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His 325 330 335 Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr 340 345 350 Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys 355 360 365 Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn 370 375 380 Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu 385 390 395 400 Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu 405 410 415 Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val 420 425 430 Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys 435 440 445 Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp 450 455 460 Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn 465 470 475 480 Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu 485 490 495 Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu 500 505 510 Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys 515 520 525 His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val 530 535 540 Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp 545 550 555 560 Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys 565 570 575 Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn 580 585 590 Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys 595 600 605 Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His 610 615 620 Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe 625 630 635 640 Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys 645 650 655 Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Cys Val Glu Pro Leu Gly 660 665 670 Met Glu Asn Gly Asn Ile Ala Asn Ser Gln Ile Ala Ala Ser Ser Val 675 680 685 Arg Val Thr Phe Leu Gly Leu Gln His Trp Val Pro Glu Leu Ala Arg 690 695 700 Leu Asn Arg Ala Gly Met Val Asn Ala Trp Thr Pro Ser Ser Asn Asp 705 710 715 720 Asp Asn Pro Trp Ile Gln Val Asn Leu Leu Arg Arg Met Trp Val Thr 725 730 735 Gly Val Val Thr Gln Gly Ala Ser Arg Leu Ala Ser His Glu Tyr Leu 740 745 750 Lys Ala Phe Lys Val Ala Tyr Ser Leu Asn Gly His Glu Phe Asp Phe 755 760 765 Ile His Asp Val Asn Lys Lys His Lys Glu Phe Val Gly Asn Trp Asn 770 775 780 Lys Asn Ala Val His Val Asn Leu Phe Glu Thr Pro Val Glu Ala Gln 785 790 795 800 Tyr Val Arg Leu Tyr Pro Thr Ser Cys His Thr Ala Cys Thr Leu Arg 805 810 815 Phe Glu Leu Leu Gly Cys Glu Leu Asn Gly Cys Ala Asn Pro Leu Gly 820 825 830 Leu Lys Asn Asn Ser Ile Pro Asp Lys Gln Ile Thr Ala Ser Ser Ser 835 840 845 Tyr Lys Thr Trp Gly Leu His Leu Phe Ser Trp Asn Pro Ser Tyr Ala 850 855 860 Arg Leu Asp Lys Gln Gly Asn Phe Asn Ala Trp Val Ala Gly Ser Tyr 865 870 875 880 Gly Asn Asp Gln Trp Leu Gln Val Asp Leu Gly Ser Ser Lys Glu Val 885 890 895 Thr Gly Ile Ile Thr Gln Gly Ala Arg Asn Phe Gly Ser Val Gln Phe 900 905 910 Val Ala Ser Tyr Lys Val Ala Tyr Ser Asn Asp Ser Ala Asn Trp Thr 915 920 925 Glu Tyr Gln Asp Pro Arg Thr Gly Ser Ser Lys Ile Phe Pro Gly Asn 930 935 940 Trp Asp Asn His Ser His Lys Lys Asn Leu Phe Glu Thr Pro Ile Leu 945 950 955 960 Ala Arg Tyr Val Arg Ile Leu Pro Val Ala Trp His Asn Arg Ile Ala 965 970 975 Leu Arg Leu Glu Leu Leu Gly Cys 980 <210> 108 <211> 2835 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 108 gacatctgcg accccaaccc ctgcgagaac ggcggcatct gcctgcccgg cctggccgac 60 ggcagcttca gctgcgagtg ccccgacggc ttcaccgacc ccaactgcag cagcgtggtg 120 gaggtggcca gcgacgagga ggagcccacc gacgcccaca agagcgaggt ggcccaccgg 180 ttcaaggacc tgggcgagga gaacttcaag gccctggtgc tgatcgcctt cgcccagtac 240 ctgcagcaga gccccttcga ggaccacgtg aagctggtga acgaggtgac cgagttcgcc 300 aagacctgcg tggccgacga gagcgccgag aactgcgaca agagcctgca caccctgttc 360 ggcgacaagc tgtgcaccgt ggccaccctg cgggagacct acggcgagat ggccgactgc 420 tgcgccaagc aggagcccga gcggaacgag tgcttcctgc agcacaagga cgacaacccc 480 aacctgcccc ggctggtgcg gcccgaggtg gacgtgatgt gcaccgcctt ccacgacaac 540 gaggagacct tcctgaagaa gtacctgtac gagatcgccc ggcggcaccc ctacttctac 600 gcccccgagc tgctgttctt cgccaagcgg tacaaggccg ccttcaccga gtgctgccag 660 gccgccgaca aggccgcctg cctgctgccc aagctggacg agctgcggga cgagggcaag 720 gccagcagcg ccaagcagcg gctgaagtgc gccagcctgc agaagttcgg cgagcgggcc 780 ttcaaggcct gggccgtggc ccggctgagc cagcggttcc ccaaggccga gttcgccgag 840 gtgagcaagc tggtgaccga cctgaccaag gtgcacaccg agtgctgcca cggcgacctg 900 ctggagtgcg ccgacgaccg ggccgacctg gccaagtaca tctgcgagaa ccaggacagc 960 atcagcagca agctgaagga gtgctgcgag aagcccctgc tggagaagag ccactgcatc 1020 gccgaggtgg agaacgacga gatgcccgcc gacctgccca gcctggccgc cgacttcgtg 1080 gagagcaagg acgtgtgcaa gaactacgcc gaggccaagg acgtgttcct gggcatgttc 1140 ctgtacgagt acgcccggcg gcaccccgac tacagcgtgg tgctgctgct gcggctggcc 1200 aagacctacg agaccaccct ggagaagtgc tgcgccgccg ccgaccccca cgagtgctac 1260 gccaaggtgt tcgacgagtt caagcccctg gtggaggagc cccagaacct gatcaagcag 1320 aactgcgagc tgttcgagca gctgggcgag tacaagttcc agaacgccct gctggtgcgg 1380 tacaccaaga aggtgcccca ggtgagcacc cccaccctgg tggaggtgag ccggaacctg 1440 ggcaaggtgg gcagcaagtg ctgcaagcac cccgaggcca agcggatgcc ctgcgccgag 1500 gactacctga gcgtggtgct gaaccagctg tgcgtgctgc acgagaagac ccccgtgagc 1560 gaccgggtga ccaagtgctg caccgagagc ctggtgaacc ggcggccctg cttcagcgcc 1620 ctggaggtgg acgagaccta cgtgcccaag gagttcaacg ccgagacctt caccttccac 1680 gccgacatct gcaccctgag cgagaaggag cggcagatca agaagcagac cgccctggtg 1740 gagctggtga agcacaagcc caaggccacc aaggagcagc tgaaggccgt gatggacgac 1800 ttcgccgcct tcgtggagaa gtgctgcaag gccgacgaca aggagacctg cttcgccgag 1860 gagggcaaga agctggtggc ctgcgtggag cccctgggca tggagaacgg caacatcgcc 1920 aacagccaga tcgccgccag cagcgtgcgg gtgaccttcc tgggcctgca gcactgggtg 1980 cccgagctgg cccggctgaa ccgggccggc atggtgaacg cctggacccc cagcagcaac 2040 gacgacaacc cctggatcca ggtgaacctg ctgcggcgga tgtgggtgac cggcgtggtg 2100 acccagggcg ccagccggct ggccagccac gagtacctga aggccttcaa ggtggcctac 2160 agcctgaacg gccacgagtt cgacttcatc cacgacgtga acaagaagca caaggagttc 2220 gtgggcaact ggaacaagaa cgccgtgcac gtgaacctgt tcgagacccc cgtggaggcc 2280 cagtacgtgc ggctgtaccc caccagctgc cacaccgcct gcaccctgcg gttcgagctg 2340 ctgggctgcg agctgaacgg ctgcgccaac cccctgggcc tgaagaacaa cagcatcccc 2400 gacaagcaga tcaccgccag cagcagctac aagacctggg gcctgcacct gttcagctgg 2460 aaccccagct acgcccggct ggacaagcag ggcaacttca acgcctgggt ggccggcagc 2520 tacggcaacg accagtggct gcaggtggac ctgggcagca gcaaggaggt gaccggcatc 2580 atcacccagg gcgcccggaa cttcggcagc gtgcagttcg tggccagcta caaggtggcc 2640 tacagcaacg acagcgccaa ctggaccgag taccaggacc cccggaccgg cagcagcaag 2700 atcttccccg gcaactggga caaccacagc cacaagaaga acctgttcga gacccccatc 2760 ctggcccggt acgtgcggat cctgcccgtg gcctggcaca accggatcgc cctgcggctg 2820 gagctgctgg gctgc 2835 <210> 109 <211> 2820 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 109 agcgccggcc cctgcacccc caacccctgc cacaacggcg gcacctgcga gatcagcgag 60 gcctaccggg gcgacacctt catcggctac gtgtgcaagt gcccccgggg cttcaacggc 120 atccactgcc agcacgacgc ccacaagagc gaggtggccc accggttcaa ggacctgggc 180 gaggagaact tcaaggccct ggtgctgatc gccttcgccc agtacctgca gcagagcccc 240 ttcgaggacc acgtgaagct ggtgaacgag gtgaccgagt tcgccaagac ctgcgtggcc 300 gacgagagcg ccgagaactg cgacaagagc ctgcacaccc tgttcggcga caagctgtgc 360 accgtggcca ccctgcggga gacctacggc gagatggccg actgctgcgc caagcaggag 420 cccgagcgga acgagtgctt cctgcagcac aaggacgaca accccaacct gccccggctg 480 gtgcggcccg aggtggacgt gatgtgcacc gccttccacg acaacgagga gaccttcctg 540 aagaagtacc tgtacgagat cgcccggcgg cacccctact tctacgcccc cgagctgctg 600 ttcttcgcca agcggtacaa ggccgccttc accgagtgct gccaggccgc cgacaaggcc 660 gcctgcctgc tgcccaagct ggacgagctg cgggacgagg gcaaggccag cagcgccaag 720 cagcggctga agtgcgccag cctgcagaag ttcggcgagc gggccttcaa ggcctgggcc 780 gtggcccggc tgagccagcg gttccccaag gccgagttcg ccgaggtgag caagctggtg 840 accgacctga ccaaggtgca caccgagtgc tgccacggcg acctgctgga gtgcgccgac 900 gaccgggccg acctggccaa gtacatctgc gagaaccagg acagcatcag cagcaagctg 960 aaggagtgct gcgagaagcc cctgctggag aagagccact gcatcgccga ggtggagaac 1020 gacgagatgc ccgccgacct gcccagcctg gccgccgact tcgtggagag caaggacgtg 1080 tgcaagaact acgccgaggc caaggacgtg ttcctgggca tgttcctgta cgagtacgcc 1140 cggcggcacc ccgactacag cgtggtgctg ctgctgcggc tggccaagac ctacgagacc 1200 accctggaga agtgctgcgc cgccgccgac ccccacgagt gctacgccaa ggtgttcgac 1260 gagttcaagc ccctggtgga ggagccccag aacctgatca agcagaactg cgagctgttc 1320 gagcagctgg gcgagtacaa gttccagaac gccctgctgg tgcggtacac caagaaggtg 1380 ccccaggtga gcacccccac cctggtggag gtgagccgga acctgggcaa ggtgggcagc 1440 aagtgctgca agcaccccga ggccaagcgg atgccctgcg ccgaggacta cctgagcgtg 1500 gtgctgaacc agctgtgcgt gctgcacgag aagacccccg tgagcgaccg ggtgaccaag 1560 tgctgcaccg agagcctggt gaaccggcgg ccctgcttca gcgccctgga ggtggacgag 1620 acctacgtgc ccaaggagtt caacgccgag accttcacct tccacgccga catctgcacc 1680 ctgagcgaga aggagcggca gatcaagaag cagaccgccc tggtggagct ggtgaagcac 1740 aagcccaagg ccaccaagga gcagctgaag gccgtgatgg acgacttcgc cgccttcgtg 1800 gagaagtgct gcaaggccga cgacaaggag acctgcttcg ccgaggaggg caagaagctg 1860 gtggcctgcg tggagcccct gggcatggag aacggcaaca tcgccaacag ccagatcgcc 1920 gccagcagcg tgcgggtgac cttcctgggc ctgcagcact gggtgcccga gctggcccgg 1980 ctgaaccggg ccggcatggt gaacgcctgg acccccagca gcaacgacga caacccctgg 2040 atccaggtga acctgctgcg gcggatgtgg gtgaccggcg tggtgaccca gggcgccagc 2100 cggctggcca gccacgagta cctgaaggcc ttcaaggtgg cctacagcct gaacggccac 2160 gagttcgact tcatccacga cgtgaacaag aagcacaagg agttcgtggg caactggaac 2220 aagaacgccg tgcacgtgaa cctgttcgag acccccgtgg aggcccagta cgtgcggctg 2280 taccccacca gctgccacac cgcctgcacc ctgcggttcg agctgctggg ctgcgagctg 2340 aacggctgcg ccaaccccct gggcctgaag aacaacagca tccccgacaa gcagatcacc 2400 gccagcagca gctacaagac ctggggcctg cacctgttca gctggaaccc cagctacgcc 2460 cggctggaca agcagggcaa cttcaacgcc tgggtggccg gcagctacgg caacgaccag 2520 tggctgcagg tggacctggg cagcagcaag gaggtgaccg gcatcatcac ccagggcgcc 2580 cggaacttcg gcagcgtgca gttcgtggcc agctacaagg tggcctacag caacgacagc 2640 gccaactgga ccgagtacca ggacccccgg accggcagca gcaagatctt ccccggcaac 2700 tgggacaacc acagccacaa gaagaacctg ttcgagaccc ccatcctggc ccggtacgtg 2760 cggatcctgc ccgtggcctg gcacaaccgg atcgccctgc ggctggagct gctgggctgc 2820 <210> 110 <211> 2802 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 110 aacatcaacg agtgcgaggt ggagccctgc aagaacggcg gcatctgcac cgacctggtg 60 gccaactaca gctgcgagtg ccccggcgag ttcatgggcc ggaactgcca gtacaaggac 120 gcccacaaga gcgaggtggc ccaccggttc aaggacctgg gcgaggagaa cttcaaggcc 180 ctggtgctga tcgccttcgc ccagtacctg cagcagagcc ccttcgagga ccacgtgaag 240 ctggtgaacg aggtgaccga gttcgccaag acctgcgtgg ccgacgagag cgccgagaac 300 tgcgacaaga gcctgcacac cctgttcggc gacaagctgt gcaccgtggc caccctgcgg 360 gagacctacg gcgagatggc cgactgctgc gccaagcagg agcccgagcg gaacgagtgc 420 ttcctgcagc acaaggacga caaccccaac ctgccccggc tggtgcggcc cgaggtggac 480 gtgatgtgca ccgccttcca cgacaacgag gagaccttcc tgaagaagta cctgtacgag 540 atcgcccggc ggcaccccta cttctacgcc cccgagctgc tgttcttcgc caagcggtac 600 aaggccgcct tcaccgagtg ctgccaggcc gccgacaagg ccgcctgcct gctgcccaag 660 ctggacgagc tgcgggacga gggcaaggcc agcagcgcca agcagcggct gaagtgcgcc 720 agcctgcaga agttcggcga gcgggccttc aaggcctggg ccgtggcccg gctgagccag 780 cggttcccca aggccgagtt cgccgaggtg agcaagctgg tgaccgacct gaccaaggtg 840 cacaccgagt gctgccacgg cgacctgctg gagtgcgccg acgaccgggc cgacctggcc 900 aagtacatct gcgagaacca ggacagcatc agcagcaagc tgaaggagtg ctgcgagaag 960 cccctgctgg agaagagcca ctgcatcgcc gaggtggaga acgacgagat gcccgccgac 1020 ctgcccagcc tggccgccga cttcgtggag agcaaggacg tgtgcaagaa ctacgccgag 1080 gccaaggacg tgttcctggg catgttcctg tacgagtacg cccggcggca ccccgactac 1140 agcgtggtgc tgctgctgcg gctggccaag acctacgaga ccaccctgga gaagtgctgc 1200 gccgccgccg acccccacga gtgctacgcc aaggtgttcg acgagttcaa gcccctggtg 1260 gaggagcccc agaacctgat caagcagaac tgcgagctgt tcgagcagct gggcgagtac 1320 aagttccaga acgccctgct ggtgcggtac accaagaagg tgccccaggt gagcaccccc 1380 accctggtgg aggtgagccg gaacctgggc aaggtgggca gcaagtgctg caagcacccc 1440 gaggccaagc ggatgccctg cgccgaggac tacctgagcg tggtgctgaa ccagctgtgc 1500 gtgctgcacg agaagacccc cgtgagcgac cgggtgacca agtgctgcac cgagagcctg 1560 gtgaaccggc ggccctgctt cagcgccctg gaggtggacg agacctacgt gcccaaggag 1620 ttcaacgccg agaccttcac cttccacgcc gacatctgca ccctgagcga gaaggagcgg 1680 cagatcaaga agcagaccgc cctggtggag ctggtgaagc acaagcccaa ggccaccaag 1740 gagcagctga aggccgtgat ggacgacttc gccgccttcg tggagaagtg ctgcaaggcc 1800 gacgacaagg agacctgctt cgccgaggag ggcaagaagc tggtggcctg cgtggagccc 1860 ctgggcatgg agaacggcaa catcgccaac agccagatcg ccgccagcag cgtgcgggtg 1920 accttcctgg gcctgcagca ctgggtgccc gagctggccc ggctgaaccg ggccggcatg 1980 gtgaacgcct ggacccccag cagcaacgac gacaacccct ggatccaggt gaacctgctg 2040 cggcggatgt gggtgaccgg cgtggtgacc cagggcgcca gccggctggc cagccacgag 2100 tacctgaagg ccttcaaggt ggcctacagc ctgaacggcc acgagttcga cttcatccac 2160 gacgtgaaca agaagcacaa ggagttcgtg ggcaactgga acaagaacgc cgtgcacgtg 2220 aacctgttcg agacccccgt ggaggcccag tacgtgcggc tgtaccccac cagctgccac 2280 accgcctgca ccctgcggtt cgagctgctg ggctgcgagc tgaacggctg cgccaacccc 2340 ctgggcctga agaacaacag catccccgac aagcagatca ccgccagcag cagctacaag 2400 acctggggcc tgcacctgtt cagctggaac cccagctacg cccggctgga caagcagggc 2460 aacttcaacg cctgggtggc cggcagctac ggcaacgacc agtggctgca ggtggacctg 2520 ggcagcagca aggaggtgac cggcatcatc acccagggcg cccggaactt cggcagcgtg 2580 cagttcgtgg ccagctacaa ggtggcctac agcaacgaca gcgccaactg gaccgagtac 2640 caggaccccc ggaccggcag cagcaagatc ttccccggca actgggacaa ccacagccac 2700 aagaagaacc tgttcgagac ccccatcctg gcccggtacg tgcggatcct gcccgtggcc 2760 tggcacaacc ggatcgccct gcggctggag ctgctgggct gc 2802 <210> 111 <211> 2970 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 111 gacatctgcg accccaaccc ctgcgagaac ggcggcatct gcctgcccgg cctggccgac 60 ggcagcttca gctgcgagtg ccccgacggc ttcaccgacc ccaactgcag cagcgtggtg 120 gaggtggcca gcgacgagga ggagcccacc agcgccggcc cctgcacccc caacccctgc 180 cacaacggcg gcacctgcga gatcagcgag gcctaccggg gcgacacctt catcggctac 240 gtgtgcaagt gcccccgggg cttcaacggc atccactgcc agcacgacgc ccacaagagc 300 gaggtggccc accggttcaa ggacctgggc gaggagaact tcaaggccct ggtgctgatc 360 gccttcgccc agtacctgca gcagagcccc ttcgaggacc acgtgaagct ggtgaacgag 420 gtgaccgagt tcgccaagac ctgcgtggcc gacgagagcg ccgagaactg cgacaagagc 480 ctgcacaccc tgttcggcga caagctgtgc accgtggcca ccctgcggga gacctacggc 540 gagatggccg actgctgcgc caagcaggag cccgagcgga acgagtgctt cctgcagcac 600 aaggacgaca accccaacct gccccggctg gtgcggcccg aggtggacgt gatgtgcacc 660 gccttccacg acaacgagga gaccttcctg aagaagtacc tgtacgagat cgcccggcgg 720 cacccctact tctacgcccc cgagctgctg ttcttcgcca agcggtacaa ggccgccttc 780 accgagtgct gccaggccgc cgacaaggcc gcctgcctgc tgcccaagct ggacgagctg 840 cgggacgagg gcaaggccag cagcgccaag cagcggctga agtgcgccag cctgcagaag 900 ttcggcgagc gggccttcaa ggcctgggcc gtggcccggc tgagccagcg gttccccaag 960 gccgagttcg ccgaggtgag caagctggtg accgacctga ccaaggtgca caccgagtgc 1020 tgccacggcg acctgctgga gtgcgccgac gaccgggccg acctggccaa gtacatctgc 1080 gagaaccagg acagcatcag cagcaagctg aaggagtgct gcgagaagcc cctgctggag 1140 aagagccact gcatcgccga ggtggagaac gacgagatgc ccgccgacct gcccagcctg 1200 gccgccgact tcgtggagag caaggacgtg tgcaagaact acgccgaggc caaggacgtg 1260 ttcctgggca tgttcctgta cgagtacgcc cggcggcacc ccgactacag cgtggtgctg 1320 ctgctgcggc tggccaagac ctacgagacc accctggaga agtgctgcgc cgccgccgac 1380 ccccacgagt gctacgccaa ggtgttcgac gagttcaagc ccctggtgga ggagccccag 1440 aacctgatca agcagaactg cgagctgttc gagcagctgg gcgagtacaa gttccagaac 1500 gccctgctgg tgcggtacac caagaaggtg ccccaggtga gcacccccac cctggtggag 1560 gtgagccgga acctgggcaa ggtgggcagc aagtgctgca agcaccccga ggccaagcgg 1620 atgccctgcg ccgaggacta cctgagcgtg gtgctgaacc agctgtgcgt gctgcacgag 1680 aagacccccg tgagcgaccg ggtgaccaag tgctgcaccg agagcctggt gaaccggcgg 1740 ccctgcttca gcgccctgga ggtggacgag acctacgtgc ccaaggagtt caacgccgag 1800 accttcacct tccacgccga catctgcacc ctgagcgaga aggagcggca gatcaagaag 1860 cagaccgccc tggtggagct ggtgaagcac aagcccaagg ccaccaagga gcagctgaag 1920 gccgtgatgg acgacttcgc cgccttcgtg gagaagtgct gcaaggccga cgacaaggag 1980 acctgcttcg ccgaggaggg caagaagctg gtggcctgcg tggagcccct gggcatggag 2040 aacggcaaca tcgccaacag ccagatcgcc gccagcagcg tgcgggtgac cttcctgggc 2100 ctgcagcact gggtgcccga gctggcccgg ctgaaccggg ccggcatggt gaacgcctgg 2160 acccccagca gcaacgacga caacccctgg atccaggtga acctgctgcg gcggatgtgg 2220 gtgaccggcg tggtgaccca gggcgccagc cggctggcca gccacgagta cctgaaggcc 2280 ttcaaggtgg cctacagcct gaacggccac gagttcgact tcatccacga cgtgaacaag 2340 aagcacaagg agttcgtggg caactggaac aagaacgccg tgcacgtgaa cctgttcgag 2400 acccccgtgg aggcccagta cgtgcggctg taccccacca gctgccacac cgcctgcacc 2460 ctgcggttcg agctgctggg ctgcgagctg aacggctgcg ccaaccccct gggcctgaag 2520 aacaacagca tccccgacaa gcagatcacc gccagcagca gctacaagac ctggggcctg 2580 cacctgttca gctggaaccc cagctacgcc cggctggaca agcagggcaa cttcaacgcc 2640 tgggtggccg gcagctacgg caacgaccag tggctgcagg tggacctggg cagcagcaag 2700 gaggtgaccg gcatcatcac ccagggcgcc cggaacttcg gcagcgtgca gttcgtggcc 2760 agctacaagg tggcctacag caacgacagc gccaactgga ccgagtacca ggacccccgg 2820 accggcagca gcaagatctt ccccggcaac tgggacaacc acagccacaa gaagaacctg 2880 ttcgagaccc ccatcctggc ccggtacgtg cggatcctgc ccgtggcctg gcacaaccgg 2940 atcgccctgc ggctggagct gctgggctgc 2970 <210> 112 <211> 2937 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 112 agcgccggcc cctgcacccc caacccctgc cacaacggcg gcacctgcga gatcagcgag 60 gcctaccggg gcgacacctt catcggctac gtgtgcaagt gcccccgggg cttcaacggc 120 atccactgcc agcacaacat caacgagtgc gaggtggagc cctgcaagaa cggcggcatc 180 tgcaccgacc tggtggccaa ctacagctgc gagtgccccg gcgagttcat gggccggaac 240 tgccagtaca aggacgccca caagagcgag gtggcccacc ggttcaagga cctgggcgag 300 gagaacttca aggccctggt gctgatcgcc ttcgcccagt acctgcagca gagccccttc 360 gaggaccacg tgaagctggt gaacgaggtg accgagttcg ccaagacctg cgtggccgac 420 gagagcgccg agaactgcga caagagcctg cacaccctgt tcggcgacaa gctgtgcacc 480 gtggccaccc tgcgggagac ctacggcgag atggccgact gctgcgccaa gcaggagccc 540 gagcggaacg agtgcttcct gcagcacaag gacgacaacc ccaacctgcc ccggctggtg 600 cggcccgagg tggacgtgat gtgcaccgcc ttccacgaca acgaggagac cttcctgaag 660 aagtacctgt acgagatcgc ccggcggcac ccctacttct acgcccccga gctgctgttc 720 ttcgccaagc ggtacaaggc cgccttcacc gagtgctgcc aggccgccga caaggccgcc 780 tgcctgctgc ccaagctgga cgagctgcgg gacgagggca aggccagcag cgccaagcag 840 cggctgaagt gcgccagcct gcagaagttc ggcgagcggg ccttcaaggc ctgggccgtg 900 gcccggctga gccagcggtt ccccaaggcc gagttcgccg aggtgagcaa gctggtgacc 960 gacctgacca aggtgcacac cgagtgctgc cacggcgacc tgctggagtg cgccgacgac 1020 cgggccgacc tggccaagta catctgcgag aaccaggaca gcatcagcag caagctgaag 1080 gagtgctgcg agaagcccct gctggagaag agccactgca tcgccgaggt ggagaacgac 1140 gagatgcccg ccgacctgcc cagcctggcc gccgacttcg tggagagcaa ggacgtgtgc 1200 aagaactacg ccgaggccaa ggacgtgttc ctgggcatgt tcctgtacga gtacgcccgg 1260 cggcaccccg actacagcgt ggtgctgctg ctgcggctgg ccaagaccta cgagaccacc 1320 ctggagaagt gctgcgccgc cgccgacccc cacgagtgct acgccaaggt gttcgacgag 1380 ttcaagcccc tggtggagga gccccagaac ctgatcaagc agaactgcga gctgttcgag 1440 cagctgggcg agtacaagtt ccagaacgcc ctgctggtgc ggtacaccaa gaaggtgccc 1500 caggtgagca cccccaccct ggtggaggtg agccggaacc tgggcaaggt gggcagcaag 1560 tgctgcaagc accccgaggc caagcggatg ccctgcgccg aggactacct gagcgtggtg 1620 ctgaaccagc tgtgcgtgct gcacgagaag acccccgtga gcgaccgggt gaccaagtgc 1680 tgcaccgaga gcctggtgaa ccggcggccc tgcttcagcg ccctggaggt ggacgagacc 1740 tacgtgccca aggagttcaa cgccgagacc ttcaccttcc acgccgacat ctgcaccctg 1800 agcgagaagg agcggcagat caagaagcag accgccctgg tggagctggt gaagcacaag 1860 cccaaggcca ccaaggagca gctgaaggcc gtgatggacg acttcgccgc cttcgtggag 1920 aagtgctgca aggccgacga caaggagacc tgcttcgccg aggagggcaa gaagctggtg 1980 gcctgcgtgg agcccctggg catggagaac ggcaacatcg ccaacagcca gatcgccgcc 2040 agcagcgtgc gggtgacctt cctgggcctg cagcactggg tgcccgagct ggcccggctg 2100 aaccgggccg gcatggtgaa cgcctggacc cccagcagca acgacgacaa cccctggatc 2160 caggtgaacc tgctgcggcg gatgtgggtg accggcgtgg tgacccaggg cgccagccgg 2220 ctggccagcc acgagtacct gaaggccttc aaggtggcct acagcctgaa cggccacgag 2280 ttcgacttca tccacgacgt gaacaagaag cacaaggagt tcgtgggcaa ctggaacaag 2340 aacgccgtgc acgtgaacct gttcgagacc cccgtggagg cccagtacgt gcggctgtac 2400 cccaccagct gccacaccgc ctgcaccctg cggttcgagc tgctgggctg cgagctgaac 2460 ggctgcgcca accccctggg cctgaagaac aacagcatcc ccgacaagca gatcaccgcc 2520 agcagcagct acaagacctg gggcctgcac ctgttcagct ggaaccccag ctacgcccgg 2580 ctggacaagc agggcaactt caacgcctgg gtggccggca gctacggcaa cgaccagtgg 2640 ctgcaggtgg acctgggcag cagcaaggag gtgaccggca tcatcaccca gggcgcccgg 2700 aacttcggca gcgtgcagtt cgtggccagc tacaaggtgg cctacagcaa cgacagcgcc 2760 aactggaccg agtaccagga cccccggacc ggcagcagca agatcttccc cggcaactgg 2820 gacaaccaca gccacaagaa gaacctgttc gagaccccca tcctggcccg gtacgtgcgg 2880 atcctgcccg tggcctggca caaccggatc gccctgcggc tggagctgct gggctgc 2937 <210> 113 <211> 2952 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 113 gacatctgcg accccaaccc ctgcgagaac ggcggcatct gcctgcccgg cctggccgac 60 ggcagcttca gctgcgagtg ccccgacggc ttcaccgacc ccaactgcag cagcgtggtg 120 gaggtggcca gcgacgagga ggagcccacc aacatcaacg agtgcgaggt ggagccctgc 180 aagaacggcg gcatctgcac cgacctggtg gccaactaca gctgcgagtg ccccggcgag 240 ttcatgggcc ggaactgcca gtacaaggac gcccacaaga gcgaggtggc ccaccggttc 300 aaggacctgg gcgaggagaa cttcaaggcc ctggtgctga tcgccttcgc ccagtacctg 360 cagcagagcc ccttcgagga ccacgtgaag ctggtgaacg aggtgaccga gttcgccaag 420 acctgcgtgg ccgacgagag cgccgagaac tgcgacaaga gcctgcacac cctgttcggc 480 gacaagctgt gcaccgtggc caccctgcgg gagacctacg gcgagatggc cgactgctgc 540 gccaagcagg agcccgagcg gaacgagtgc ttcctgcagc acaaggacga caaccccaac 600 ctgccccggc tggtgcggcc cgaggtggac gtgatgtgca ccgccttcca cgacaacgag 660 gagaccttcc tgaagaagta cctgtacgag atcgcccggc ggcaccccta cttctacgcc 720 cccgagctgc tgttcttcgc caagcggtac aaggccgcct tcaccgagtg ctgccaggcc 780 gccgacaagg ccgcctgcct gctgcccaag ctggacgagc tgcgggacga gggcaaggcc 840 agcagcgcca agcagcggct gaagtgcgcc agcctgcaga agttcggcga gcgggccttc 900 aaggcctggg ccgtggcccg gctgagccag cggttcccca aggccgagtt cgccgaggtg 960 agcaagctgg tgaccgacct gaccaaggtg cacaccgagt gctgccacgg cgacctgctg 1020 gagtgcgccg acgaccgggc cgacctggcc aagtacatct gcgagaacca ggacagcatc 1080 agcagcaagc tgaaggagtg ctgcgagaag cccctgctgg agaagagcca ctgcatcgcc 1140 gaggtggaga acgacgagat gcccgccgac ctgcccagcc tggccgccga cttcgtggag 1200 agcaaggacg tgtgcaagaa ctacgccgag gccaaggacg tgttcctggg catgttcctg 1260 tacgagtacg cccggcggca ccccgactac agcgtggtgc tgctgctgcg gctggccaag 1320 acctacgaga ccaccctgga gaagtgctgc gccgccgccg acccccacga gtgctacgcc 1380 aaggtgttcg acgagttcaa gcccctggtg gaggagcccc agaacctgat caagcagaac 1440 tgcgagctgt tcgagcagct gggcgagtac aagttccaga acgccctgct ggtgcggtac 1500 accaagaagg tgccccaggt gagcaccccc accctggtgg aggtgagccg gaacctgggc 1560 aaggtgggca gcaagtgctg caagcacccc gaggccaagc ggatgccctg cgccgaggac 1620 tacctgagcg tggtgctgaa ccagctgtgc gtgctgcacg agaagacccc cgtgagcgac 1680 cgggtgacca agtgctgcac cgagagcctg gtgaaccggc ggccctgctt cagcgccctg 1740 gaggtggacg agacctacgt gcccaaggag ttcaacgccg agaccttcac cttccacgcc 1800 gacatctgca ccctgagcga gaaggagcgg cagatcaaga agcagaccgc cctggtggag 1860 ctggtgaagc acaagcccaa ggccaccaag gagcagctga aggccgtgat ggacgacttc 1920 gccgccttcg tggagaagtg ctgcaaggcc gacgacaagg agacctgctt cgccgaggag 1980 ggcaagaagc tggtggcctg cgtggagccc ctgggcatgg agaacggcaa catcgccaac 2040 agccagatcg ccgccagcag cgtgcgggtg accttcctgg gcctgcagca ctgggtgccc 2100 gagctggccc ggctgaaccg ggccggcatg gtgaacgcct ggacccccag cagcaacgac 2160 gacaacccct ggatccaggt gaacctgctg cggcggatgt gggtgaccgg cgtggtgacc 2220 cagggcgcca gccggctggc cagccacgag tacctgaagg ccttcaaggt ggcctacagc 2280 ctgaacggcc acgagttcga cttcatccac gacgtgaaca agaagcacaa ggagttcgtg 2340 ggcaactgga acaagaacgc cgtgcacgtg aacctgttcg agacccccgt ggaggcccag 2400 tacgtgcggc tgtaccccac cagctgccac accgcctgca ccctgcggtt cgagctgctg 2460 ggctgcgagc tgaacggctg cgccaacccc ctgggcctga agaacaacag catccccgac 2520 aagcagatca ccgccagcag cagctacaag acctggggcc tgcacctgtt cagctggaac 2580 cccagctacg cccggctgga caagcagggc aacttcaacg cctgggtggc cggcagctac 2640 ggcaacgacc agtggctgca ggtggacctg ggcagcagca aggaggtgac cggcatcatc 2700 acccagggcg cccggaactt cggcagcgtg cagttcgtgg ccagctacaa ggtggcctac 2760 agcaacgaca gcgccaactg gaccgagtac caggaccccc ggaccggcag cagcaagatc 2820 ttccccggca actgggacaa ccacagccac aagaagaacc tgttcgagac ccccatcctg 2880 gcccggtacg tgcggatcct gcccgtggcc tggcacaacc ggatcgccct gcggctggag 2940 ctgctgggct gc 2952 <210> 114 <211> 5 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Péptido Sintético" <400> 114 Gly Gly Gly Gly Ser 1 5 <210> 115 <211> 212 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 115 Leu Asp Ile Cys Ser Lys Asn Pro Cys His Asn Gly Gly Leu Cys Glu 1 5 10 15 Glu Ile Ser Gln Glu Val Arg Gly Asp Val Phe Pro Ser Tyr Thr Cys 20 25 30 Thr Cys Leu Lys Gly Tyr Ala Gly Asn His Cys Glu Thr Lys Cys Val 35 40 45 Glu Pro Leu Gly Met Glu Asn Gly Asn Ile Ala Asn Ser Gln Ile Ala 50 55 60 Ala Ser Ser Val Arg Val Thr Phe Leu Gly Leu Gln His Trp Val Pro 65 70 75 80 Glu Leu Ala Arg Leu Asn Arg Ala Gly Met Val Asn Ala Trp Thr Pro 85 90 95 Ser Ser Asn Asp Asp Asn Pro Trp Ile Gln Val Asn Leu Leu Arg Arg 100 105 110 Met Trp Val Thr Gly Val Val Thr Gln Gly Ala Ser Arg Leu Ala Ser 115 120 125 His Glu Tyr Leu Lys Ala Phe Lys Val Ala Tyr Ser Leu Asn Gly His 130 135 140 Glu Phe Asp Phe Ile His Asp Val Asn Lys Lys His Lys Glu Phe Val 145 150 155 160 Gly Asn Trp Asn Lys Asn Ala Val His Val Asn Leu Phe Glu Thr Pro 165 170 175 Val Glu Ala Gln Tyr Val Arg Leu Tyr Pro Thr Ser Cys His Thr Ala 180 185 190 Cys Thr Leu Arg Phe Glu Leu Leu Gly Cys Glu Leu Asn Gly His His 195 200 205 His His His His 210 <210> 116 <211> 636 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 116 ctggacatct gtagcaagaa cccttgccac aacggcggcc tgtgcgaaga gatttctcaa 60 gaagtgcggg gcgacgtttt ccccagctac acctgtacat gtctgaaggg ctacgccggc 120 aaccactgcg agacaaaatg tgtggaaccc ctcggcatgg aaaacggcaa tatcgccaat 180 agccagatcg ccgccagcag cgtcagagtg acatttctgg gactgcaaca ctgggtgcca 240 gagctggcca gactgaatag agccggcatg gttaacgcct ggacacccag cagcaacgac 300 gacaacccct ggattcaagt gaacctgctg cggcgtatgt gggtcacagg tgttgttaca 360 cagggcgcaa gcagactggc cagccacgag tatctgaagg cctttaaggt ggcctacagc 420 ctgaacggcc acgagttcga cttcatccac gacgtgaaca agaagcacaa agagttcgtc 480 ggcaactgga acaagaacgc cgtgcacgtg aacctgttcg agacacctgt ggaagcccag 540 tacgtgcggc tgtaccctac aagctgtcac accgcctgca cactgagatt cgagctgctg 600 ggctgtgaac tgaatggcca ccaccaccat caccac 636 <210> 117 <211> 805 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 117 Leu Asp Ile Cys Ser Lys Asn Pro Cys His Asn Gly Gly Leu Cys Glu 1 5 10 15 Glu Ile Ser Gln Glu Val Arg Gly Asp Val Phe Pro Ser Tyr Thr Cys 20 25 30 Thr Cys Leu Lys Gly Tyr Ala Gly Asn His Cys Glu Thr Lys Gly Ser 35 40 45 Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 50 55 60 Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 65 70 75 80 Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 85 90 95 Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 100 105 110 Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 115 120 125 Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 130 135 140 Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 145 150 155 160 Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 165 170 175 Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 180 185 190 Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 195 200 205 Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 210 215 220 Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 225 230 235 240 Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 245 250 255 Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 260 265 270 Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 275 280 285 Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 290 295 300 Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 305 310 315 320 Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 325 330 335 Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 340 345 350 Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 355 360 365 Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 370 375 380 Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 385 390 395 400 Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 405 410 415 Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 420 425 430 Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 435 440 445 Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 450 455 460 Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 465 470 475 480 Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 485 490 495 Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 500 505 510 Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 515 520 525 Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 530 535 540 Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 545 550 555 560 Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 565 570 575 Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 580 585 590 Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 595 600 605 Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 610 615 620 Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Ser Gly Gly Ser Gly 625 630 635 640 Gly Ser Gly Gly Ser Cys Val Glu Pro Leu Gly Met Glu Asn Gly Asn 645 650 655 Ile Ala Asn Ser Gln Ile Ala Ala Ser Ser Val Arg Val Thr Phe Leu 660 665 670 Gly Leu Gln His Trp Val Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly 675 680 685 Met Val Asn Ala Trp Thr Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile 690 695 700 Gln Val Asn Leu Leu Arg Arg Met Trp Val Thr Gly Val Val Thr Gln 705 710 715 720 Gly Ala Ser Arg Leu Ala Ser His Glu Tyr Leu Lys Ala Phe Lys Val 725 730 735 Ala Tyr Ser Leu Asn Gly His Glu Phe Asp Phe Ile His Asp Val Asn 740 745 750 Lys Lys His Lys Glu Phe Val Gly Asn Trp Asn Lys Asn Ala Val His 755 760 765 Val Asn Leu Phe Glu Thr Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr 770 775 780 Pro Thr Ser Cys His Thr Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly 785 790 795 800 Cys Glu Leu Asn Gly 805 <210> 118 <211> 2415 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 118 ctggacatct gtagcaagaa cccttgccac aacggcggcc tgtgcgaaga gatttctcaa 60 gaagtgcggg gcgacgtttt ccccagctac acctgtacat gtctgaaggg ctacgccggc 120 aaccactgcg agacaaaagg atctgatgcc cacaagagcg aggtggccca cagattcaag 180 gatctgggcg aagagaactt caaggccctg gtgctgatcg ccttcgctca gtatctccag 240 cagagccctt tcgaggacca cgtgaagctg gtcaacgaag tgaccgagtt cgccaagacc 300 tgtgtggccg atgagagcgc cgagaactgt gataagagcc tgcacaccct gttcggcgac 360 aagctgtgta cagtggccac actgagagaa acctacggcg agatggccga ctgctgtgcc 420 aagcaagagc ccgagagaaa cgagtgcttc ctccagcaca aggacgacaa ccccaacctg 480 cctagactcg tgcgacccga agtggatgtg atgtgcaccg cctttcacga caacgaggaa 540 accttcctga agaagtacct gtacgagatc gccagacggc acccctactt ttatgcccct 600 gagctgctgt tcttcgccaa gcggtataag gccgccttca ccgaatgttg ccaggccgct 660 gataaggctg cctgtctgct gcctaagctg gacgagctga gagatgaggg caaagccagc 720 tctgccaagc agagactgaa atgcgccagc ctccagaagt tcggcgagag agcttttaag 780 gcctgggccg ttgccagact gagccagaga tttcctaagg ccgagtttgc cgaggtgtcc 840 aagctcgtga ccgatctgac aaaggtgcac accgagtgct gtcacggcga tctgctggaa 900 tgtgccgacg atagagccga cctggccaag tacatctgcg agaaccagga cagcatcagc 960 agcaagctga aagagtgctg cgagaagccc ctgctggaaa agtctcactg tatcgccgag 1020 gtggaaaacg acgagatgcc tgccgatctg cctagcctgg ctgccgattt cgtggaaagc 1080 aaggacgtgt gcaagaacta cgccgaggcc aaggatgtgt ttctgggcat gtttctgtat 1140 gagtacgccc gcagacaccc cgactattct gtggttctgc tgctgcggct ggccaaaacc 1200 tacgagacaa ccctggaaaa atgctgcgcc gctgccgatc ctcacgagtg ttatgccaag 1260 gtgttcgacg agttcaagcc tctggtggaa gaaccccaga acctgatcaa gcagaactgc 1320 gagctgttcg agcagctggg cgagtacaag ttccagaatg ccctgctcgt gcggtacacc 1380 aagaaagtgc ctcaggtgtc cacacctaca ctggttgagg tgtcccggaa tctgggcaaa 1440 gtgggcagca agtgttgcaa gcaccctgag gccaagagaa tgccttgcgc cgaggattac 1500 ctgagcgtgg tgctgaatca gctgtgcgtg ctgcacgaga aaacccctgt gtccgacaga 1560 gtgaccaagt gctgtaccga gagcctcgtg aacagaaggc cttgctttag cgccctggaa 1620 gtggacgaga catacgtgcc caaagagttc aacgccgaga cattcacctt ccacgccgac 1680 atctgcaccc tgtccgagaa agagcggcag atcaagaagc agacagccct ggtcgagctg 1740 gttaagcaca agcccaaggc caccaaagaa cagctgaagg ccgtgatgga cgacttcgcc 1800 gcctttgtcg agaagtgctg caaggccgac gacaaagaga catgcttcgc cgaagagggc 1860 aagaaactgg tggctgcctc tcaggctgct ctcggacttg gtggaagcgg aggaagtggt 1920 ggatctggcg gatcttgtgt ggaacccctc ggcatggaaa acggcaatat cgccaatagc 1980 cagattgccg ccagcagcgt cagagtgaca tttctgggac tgcaacactg ggtgcccgag 2040 ctggctagac tgaatagagc cggcatggtc aacgcctgga cacccagcag caacgacgat 2100 aatccctgga ttcaagtgaa cctgctgcgg cgtatgtggg tcacaggtgt tgttacacag 2160 ggcgcaagca gactggccag ccacgagtat ctgaaggcct ttaaggtggc ctacagcctg 2220 aacggccacg agttcgactt catccacgac gtgaacaaga agcacaaaga gtttgtcggc 2280 aactggaaca agaacgccgt gcacgtgaac ctgttcgaga cacctgtgga agcccagtac 2340 gtgcggctgt accctacaag ctgtcacacc gcctgcactc tgagattcga actgctggga 2400 tgcgagctga acggc 2415 <210> 119 <211> 789 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 119 Leu Asp Ile Cys Ser Lys Asn Pro Cys His Asn Gly Gly Leu Cys Glu 1 5 10 15 Glu Ile Ser Gln Glu Val Arg Gly Asp Val Phe Pro Ser Tyr Thr Cys 20 25 30 Thr Cys Leu Lys Gly Tyr Ala Gly Asn His Cys Glu Thr Lys Asp Ala 35 40 45 His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn 50 55 60 Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Ser 65 70 75 80 Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala 85 90 95 Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu 100 105 110 His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu 115 120 125 Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg 130 135 140 Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg 145 150 155 160 Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn 165 170 175 Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His 180 185 190 Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys 195 200 205 Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu 210 215 220 Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala 225 230 235 240 Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala 245 250 255 Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala 260 265 270 Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His 275 280 285 Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala 290 295 300 Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys 305 310 315 320 Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile 325 330 335 Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala 340 345 350 Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala 355 360 365 Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His 370 375 380 Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu 385 390 395 400 Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr 405 410 415 Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn 420 425 430 Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys 435 440 445 Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val 450 455 460 Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly 465 470 475 480 Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu 485 490 495 Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys 500 505 510 Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val 515 520 525 Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val 530 535 540 Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys 545 550 555 560 Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val 565 570 575 Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala 580 585 590 Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp 595 600 605 Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala 610 615 620 Ser Gln Ala Ala Leu Cys Val Glu Pro Leu Gly Met Glu Asn Gly Asn 625 630 635 640 Ile Ala Asn Ser Gln Ile Ala Ala Ser Ser Val Arg Val Thr Phe Leu 645 650 655 Gly Leu Gln His Trp Val Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly 660 665 670 Met Val Asn Ala Trp Thr Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile 675 680 685 Gln Val Asn Leu Leu Arg Arg Met Trp Val Thr Gly Val Val Thr Gln 690 695 700 Gly Ala Ser Arg Leu Ala Ser His Glu Tyr Leu Lys Ala Phe Lys Val 705 710 715 720 Ala Tyr Ser Leu Asn Gly His Glu Phe Asp Phe Ile His Asp Val Asn 725 730 735 Lys Lys His Lys Glu Phe Val Gly Asn Trp Asn Lys Asn Ala Val His 740 745 750 Val Asn Leu Phe Glu Thr Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr 755 760 765 Pro Thr Ser Cys His Thr Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly 770 775 780 Cys Glu Leu Asn Gly 785 <210> 120 <211> 2367 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 120 ctggacatct gtagcaagaa cccttgccac aacggcggcc tgtgcgaaga gatttctcaa 60 gaagtgcggg gcgacgtttt ccccagctac acctgtacat gtctgaaggg ctacgccggc 120 aaccactgcg agacaaagga tgcccacaag agcgaggtgg cccacagatt caaggatctg 180 ggcgaagaga acttcaaggc cctggtgctg atcgccttcg ctcagtatct ccagcagagc 240 cctttcgagg accacgtgaa gctggtcaac gaagtgaccg agttcgccaa gacctgtgtg 300 gccgatgaga gcgccgagaa ctgtgataag agcctgcaca ccctgttcgg cgacaagctg 360 tgtacagtgg ccacactgag agaaacctac ggcgagatgg ccgactgctg tgccaagcaa 420 gagcccgaga gaaacgagtg cttcctccag cacaaggacg acaaccccaa cctgcctaga 480 ctcgtgcgac ccgaagtgga tgtgatgtgc accgcctttc acgacaacga ggaaaccttc 540 ctgaagaagt acctgtacga gatcgccaga cggcacccct acttttatgc ccctgagctg 600 ctgttcttcg ccaagcggta taaggccgcc ttcaccgaat gttgccaggc cgctgataag 660 gctgcctgtc tgctgcctaa gctggacgag ctgagagatg agggcaaagc cagctctgcc 720 aagcagagac tgaaatgcgc cagcctccag aagttcggcg agagagcttt taaggcctgg 780 gccgttgcca gactgagcca gagatttcct aaggccgagt ttgccgaggt gtccaagctc 840 gtgaccgatc tgacaaaggt gcacaccgag tgctgtcacg gcgatctgct ggaatgtgcc 900 gacgatagag ccgacctggc caagtacatc tgcgagaacc aggacagcat cagcagcaag 960 ctgaaagagt gctgcgagaa gcccctgctg gaaaagtctc actgtatcgc cgaggtggaa 1020 aacgacgaga tgcctgccga tctgcctagc ctggctgccg atttcgtgga aagcaaggac 1080 gtgtgcaaga actacgccga ggccaaggat gtgtttctgg gcatgtttct gtatgagtac 1140 gcccgcagac accccgacta ttctgtggtt ctgctgctgc ggctggccaa aacctacgag 1200 acaaccctgg aaaaatgctg cgccgctgcc gatcctcacg agtgttatgc caaggtgttc 1260 gacgagttca agcctctggt ggaagaaccc cagaacctga tcaagcagaa ctgcgagctg 1320 ttcgagcagc tgggcgagta caagttccag aatgccctgc tcgtgcggta caccaagaaa 1380 gtgcctcagg tgtccacacc tacactggtt gaggtgtccc ggaatctggg caaagtgggc 1440 agcaagtgtt gcaagcaccc tgaggccaag agaatgcctt gcgccgagga ttacctgagc 1500 gtggtgctga atcagctgtg cgtgctgcac gagaaaaccc ctgtgtccga cagagtgacc 1560 aagtgctgta ccgagagcct cgtgaacaga aggccttgct ttagcgccct ggaagtggac 1620 gagacatacg tgcccaaaga gttcaacgcc gagacattca ccttccacgc cgacatctgc 1680 accctgtccg agaaagagcg gcagatcaag aagcagacag ccctggtcga gctggttaag 1740 cacaagccca aggccaccaa agaacagctg aaggccgtga tggacgactt cgccgccttt 1800 gtcgagaagt gctgcaaggc cgacgacaaa gagacatgct tcgccgaaga gggcaagaaa 1860 ctggtggctg cttctcaggc cgctctgtgt gtggaacccc tcggcatgga aaacggcaat 1920 atcgccaata gccagattgc cgccagcagc gtcagagtga catttctggg actgcaacac 1980 tgggtgcccg agctggctag actgaataga gccggcatgg tcaacgcctg gacacccagc 2040 agcaacgacg ataatccctg gattcaagtg aacctgctgc ggcgtatgtg ggtcacaggt 2100 gttgttacac agggcgcaag cagactggcc agccacgagt atctgaaggc ctttaaggtg 2160 gcctacagcc tgaacggcca cgagttcgac ttcatccacg acgtgaacaa gaagcacaaa 2220 gagtttgtcg gcaactggaa caagaacgcc gtgcacgtga acctgttcga gacacctgtg 2280 gaagcccagt acgtgcggct gtaccctaca agctgtcaca ccgcctgcac tctgagattc 2340 gaactgctgg gatgcgagct gaacggc 2367 <210> 121 <211> 783 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 121 Leu Asp Ile Cys Ser Lys Asn Pro Cys His Asn Gly Gly Leu Cys Glu 1 5 10 15 Glu Ile Ser Gln Glu Val Arg Gly Asp Val Phe Pro Ser Tyr Thr Cys 20 25 30 Thr Cys Leu Lys Gly Tyr Ala Gly Asn His Cys Glu Thr Lys Asp Ala 35 40 45 His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn 50 55 60 Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Ser 65 70 75 80 Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala 85 90 95 Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu 100 105 110 His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu 115 120 125 Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg 130 135 140 Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg 145 150 155 160 Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn 165 170 175 Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His 180 185 190 Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys 195 200 205 Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu 210 215 220 Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala 225 230 235 240 Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala 245 250 255 Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala 260 265 270 Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His 275 280 285 Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala 290 295 300 Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys 305 310 315 320 Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile 325 330 335 Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala 340 345 350 Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala 355 360 365 Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His 370 375 380 Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu 385 390 395 400 Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr 405 410 415 Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn 420 425 430 Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys 435 440 445 Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val 450 455 460 Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly 465 470 475 480 Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu 485 490 495 Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys 500 505 510 Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val 515 520 525 Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val 530 535 540 Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys 545 550 555 560 Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val 565 570 575 Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala 580 585 590 Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp 595 600 605 Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Cys 610 615 620 Val Glu Pro Leu Gly Met Glu Asn Gly Asn Ile Ala Asn Ser Gln Ile 625 630 635 640 Ala Ala Ser Ser Val Arg Val Thr Phe Leu Gly Leu Gln His Trp Val 645 650 655 Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly Met Val Asn Ala Trp Thr 660 665 670 Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile Gln Val Asn Leu Leu Arg 675 680 685 Arg Met Trp Val Thr Gly Val Val Thr Gln Gly Ala Ser Arg Leu Ala 690 695 700 Ser His Glu Tyr Leu Lys Ala Phe Lys Val Ala Tyr Ser Leu Asn Gly 705 710 715 720 His Glu Phe Asp Phe Ile His Asp Val Asn Lys Lys His Lys Glu Phe 725 730 735 Val Gly Asn Trp Asn Lys Asn Ala Val His Val Asn Leu Phe Glu Thr 740 745 750 Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr Pro Thr Ser Cys His Thr 755 760 765 Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly Cys Glu Leu Asn Gly 770 775 780 <210> 122 <211> 2349 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 122 ctggacatct gtagcaagaa cccttgccac aacggcggcc tgtgcgaaga gatttctcaa 60 gaagtgcggg gcgacgtttt ccccagctac acctgtacat gtctgaaggg ctacgccggc 120 aaccactgcg agacaaagga tgcccacaag agcgaggtgg cccacagatt caaggatctg 180 ggcgaagaga acttcaaggc cctggtgctg atcgccttcg ctcagtatct ccagcagagc 240 cctttcgagg accacgtgaa gctggtcaac gaagtgaccg agttcgccaa gacctgtgtg 300 gccgatgaga gcgccgagaa ctgtgataag agcctgcaca ccctgttcgg cgacaagctg 360 tgtacagtgg ccacactgag agaaacctac ggcgagatgg ccgactgctg tgccaagcaa 420 gagcccgaga gaaacgagtg cttcctccag cacaaggacg acaaccccaa cctgcctaga 480 ctcgtgcgac ccgaagtgga tgtgatgtgc accgcctttc acgacaacga ggaaaccttc 540 ctgaagaagt acctgtacga gatcgccaga cggcacccct acttttatgc ccctgagctg 600 ctgttcttcg ccaagcggta taaggccgcc ttcaccgaat gttgccaggc cgctgataag 660 gctgcctgtc tgctgcctaa gctggacgag ctgagagatg agggcaaagc cagctctgcc 720 aagcagagac tgaaatgcgc cagcctccag aagttcggcg agagagcttt taaggcctgg 780 gccgttgcca gactgagcca gagatttcct aaggccgagt ttgccgaggt gtccaagctc 840 gtgaccgatc tgacaaaggt gcacaccgag tgctgtcacg gcgatctgct ggaatgtgcc 900 gacgatagag ccgacctggc caagtacatc tgcgagaacc aggacagcat cagcagcaag 960 ctgaaagagt gctgcgagaa gcccctgctg gaaaagtctc actgtatcgc cgaggtggaa 1020 aacgacgaga tgcctgccga tctgcctagc ctggctgccg atttcgtgga aagcaaggac 1080 gtgtgcaaga actacgccga ggccaaggat gtgtttctgg gcatgtttct gtatgagtac 1140 gcccgcagac accccgacta ttctgtggtt ctgctgctgc ggctggccaa aacctacgag 1200 acaaccctgg aaaaatgctg cgccgctgcc gatcctcacg agtgttatgc caaggtgttc 1260 gacgagttca agcctctggt ggaagaaccc cagaacctga tcaagcagaa ctgcgagctg 1320 ttcgagcagc tgggcgagta caagttccag aatgccctgc tcgtgcggta caccaagaaa 1380 gtgcctcagg tgtccacacc tacactggtt gaggtgtccc ggaatctggg caaagtgggc 1440 agcaagtgtt gcaagcaccc tgaggccaag agaatgcctt gcgccgagga ttacctgagc 1500 gtggtgctga atcagctgtg cgtgctgcac gagaaaaccc ctgtgtccga cagagtgacc 1560 aagtgctgta ccgagagcct cgtgaacaga aggccttgct ttagcgccct ggaagtggac 1620 gagacatacg tgcccaaaga gttcaacgcc gagacattca ccttccacgc cgacatctgc 1680 accctgtccg agaaagagcg gcagatcaag aagcagacag ccctggtcga gctggttaag 1740 cacaagccca aggccaccaa agaacagctg aaggccgtga tggacgactt cgccgccttt 1800 gtcgagaagt gctgcaaggc cgacgacaaa gagacatgct tcgccgaaga gggcaagaaa 1860 ctggtggcct gtgtggaacc cctcggcatg gaaaacggca atatcgccaa tagccagatt 1920 gccgccagca gcgtcagagt gacatttctg ggactgcaac actgggtgcc cgagctggct 1980 agactgaata gagccggcat ggtcaacgcc tggacaccca gcagcaacga cgataatccc 2040 tggattcaag tgaacctgct gcggcgtatg tgggtcacag gtgttgttac acagggcgca 2100 agcagactgg ccagccacga gtatctgaag gcctttaagg tggcctacag cctgaacggc 2160 cacgagttcg acttcatcca cgacgtgaac aagaagcaca aagagtttgt cggcaactgg 2220 aacaagaacg ccgtgcacgt gaacctgttc gagacacctg tggaagccca gtacgtgcgg 2280 ctgtacccta caagctgtca caccgcctgc actctgagat tcgaactgct gggatgcgag 2340 ctgaacggc 2349 <210> 123 <211> 227 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 123 Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 1 5 10 15 Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 20 25 30 Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Val Ser His 35 40 45 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 50 55 60 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 65 70 75 80 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 85 90 95 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile 100 105 110 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 115 120 125 Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 130 135 140 Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 145 150 155 160 Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 165 170 175 Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 180 185 190 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 195 200 205 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 210 215 220 Pro Gly Lys 225 <210> 124 <211> 681 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 124 gataagaccc acacctgtcc tccatgtcct gctccagaac tgctcggcgg accctccgtt 60 ttcctgtttc cacctaagcc taaggacacc ctgatgatca gcagaacccc tgaagtgacc 120 tgtgtggtgg tggccgtgtc tcacgaagat cccgaagtga agttcaattg gtacgtggac 180 ggcgtggaag tgcacaacgc caagaccaag cctagagagg aacagtacaa cagcacctac 240 agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag 300 tgcaaggtgt ccaacaaggc cctggccgct cctatcgaga aaaccatctc taaggccaag 360 ggccagcctc gggaacctca agtctgtaca ctgcctccta gccgggacga gctgaccaaa 420 aatcaggtgt ccctgagctg cgccgtgaag ggcttttacc cttccgatat cgccgtggaa 480 tgggagagca atggccagcc tgagaacaac tacaagacca cacctcctgt gctggacagc 540 gacggctcat tctttctggt gtccaagctg acagtggaca agagcagatg gcagcagggc 600 aacgtgttca gctgttctgt gatgcacgag gccctgcaca accactacac ccagaagtct 660 ctgtctctga gccccggcaa a 681 <210> 125 <211> 605 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 125 Leu Asp Ile Cys Ser Lys Asn Pro Cys His Asn Gly Gly Leu Cys Glu 1 5 10 15 Glu Ile Ser Gln Glu Val Arg Gly Asp Val Phe Pro Ser Tyr Thr Cys 20 25 30 Thr Cys Leu Lys Gly Tyr Ala Gly Asn His Cys Glu Thr Lys Gly Ser 35 40 45 Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 50 55 60 Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 65 70 75 80 Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Val Ser His 85 90 95 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 100 105 110 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 115 120 125 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 130 135 140 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile 145 150 155 160 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 165 170 175 Tyr Thr Leu Pro Pro Cys Arg Glu Glu Met Thr Lys Asn Gln Val Ser 180 185 190 Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 195 200 205 Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 210 215 220 Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 225 230 235 240 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 245 250 255 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 260 265 270 Pro Gly Lys Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Cys 275 280 285 Val Glu Pro Leu Gly Met Glu Asn Gly Asn Ile Ala Asn Ser Gln Ile 290 295 300 Ala Ala Ser Ser Val Arg Val Thr Phe Leu Gly Leu Gln His Trp Val 305 310 315 320 Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly Met Val Asn Ala Trp Thr 325 330 335 Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile Gln Val Asn Leu Leu Arg 340 345 350 Arg Met Trp Val Thr Gly Val Val Thr Gln Gly Ala Ser Arg Leu Ala 355 360 365 Ser His Glu Tyr Leu Lys Ala Phe Lys Val Ala Tyr Ser Leu Asn Gly 370 375 380 His Glu Phe Asp Phe Ile His Asp Val Asn Lys Lys His Lys Glu Phe 385 390 395 400 Val Gly Asn Trp Asn Lys Asn Ala Val His Val Asn Leu Phe Glu Thr 405 410 415 Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr Pro Thr Ser Cys His Thr 420 425 430 Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly Cys Glu Leu Asn Gly Cys 435 440 445 Ala Asn Pro Leu Gly Leu Lys Asn Asn Ser Ile Pro Asp Lys Gln Ile 450 455 460 Thr Ala Ser Ser Ser Tyr Lys Thr Trp Gly Leu His Leu Phe Ser Trp 465 470 475 480 Asn Pro Ser Tyr Ala Arg Leu Asp Lys Gln Gly Asn Phe Asn Ala Trp 485 490 495 Val Ala Gly Ser Tyr Gly Asn Asp Gln Trp Leu Gln Val Asp Leu Gly 500 505 510 Ser Ser Lys Glu Val Thr Gly Ile Ile Thr Gln Gly Ala Arg Asn Phe 515 520 525 Gly Ser Val Gln Phe Val Ala Ser Tyr Lys Val Ala Tyr Ser Asn Asp 530 535 540 Ser Ala Asn Trp Thr Glu Tyr Gln Asp Pro Arg Thr Gly Ser Ser Lys 545 550 555 560 Ile Phe Pro Gly Asn Trp Asp Asn His Ser His Lys Lys Asn Leu Phe 565 570 575 Glu Thr Pro Ile Leu Ala Arg Tyr Val Arg Ile Leu Pro Val Ala Trp 580 585 590 His Asn Arg Ile Ala Leu Arg Leu Glu Leu Leu Gly Cys 595 600 605 <210> 126 <211> 1815 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 126 ctggacatct gtagcaagaa cccttgccac aacggcggcc tgtgcgaaga gatttctcaa 60 gaagtgcggg gcgacgtttt ccccagctac acctgtacat gtctgaaggg ctacgccggc 120 aaccactgcg agacaaaggg cagcgataag acccacacct gtcctccatg tcctgctcca 180 gaactgctcg gcggaccctc cgttttcctg tttccaccta agcctaagga caccctgatg 240 atcagcagaa cccctgaagt gacctgtgtg gtggtggccg tgtctcacga agatcccgaa 300 gtgaagttca attggtacgt ggacggcgtg gaagtgcaca acgccaagac caagcctaga 360 gaggaacagt acaacagcac ctacagagtg gtgtccgtgc tgaccgtgct gcaccaggat 420 tggctgaacg gcaaagagta caagtgcaag gtgtccaaca aggccctggc cgctcctatc 480 gagaaaacca tctctaaggc caagggccag cctcgggaac ctcaggttta caccctgcct 540 ccatgccggg aagagatgac caagaatcag gtgtccctgt ggtgcctggt caagggcttc 600 tacccttccg atatcgccgt ggaatgggag agcaatggcc agcctgagaa caactacaag 660 accacacctc ctgtgctgga cagcgacggc tcattcttcc tgtacagcaa gctgacagtg 720 gacaagagca gatggcagca gggcaacgtg ttcagctgtt ctgtgatgca cgaggccctg 780 cacaaccact acacccagaa gtctctgtct ctgagccctg gcaaaggcgg aagcggtgga 840 agcggaggat ctggcggatc ttgtgtggaa cccctcggca tggaaaacgg caatatcgcc 900 aatagccaga tcgccgccag cagcgtcaga gtgacatttc tgggactgca acactgggtg 960 ccagagctgg ccagactgaa tagagccggc atggttaacg cctggacacc cagcagcaac 1020 gacgacaacc cctggattca agtgaacctg ctgcggcgta tgtgggtcac aggtgttgtt 1080 acacagggcg caagcagact ggccagccac gagtatctga aggcctttaa ggtggcctac 1140 agcctgaacg gccacgagtt cgacttcatc cacgacgtga acaagaagca caaagagttc 1200 gtcggcaact ggaacaagaa cgccgtgcac gtgaacctgt tcgagacacc tgtggaagcc 1260 cagtacgtgc ggctgtaccc tacaagctgt cacaccgcct gcacactgag attcgagctg 1320 ctgggctgcg agctgaatgg ctgtgctaat cctctgggcc tgaagaacaa tagcatcccc 1380 gacaagcaga tcaccgcctc cagcagctat aagacatggg gcctgcacct gtttagctgg 1440 aaccctagct acgccagact ggacaagcag ggaaacttca atgcctgggt ggccggcagc 1500 tacggcaatg atcaatggct gcaagtggac ctgggcagca gcaaagaagt gaccggcatc 1560 attacccagg gcgctagaaa tttcggcagc gtgcagttcg tggccagcta caaagtggcc 1620 tactccaacg acagcgccaa ctggaccgag tatcaggacc ctagaaccgg cagctccaag 1680 atcttccccg gcaattggga caaccacagc cacaagaaga atctgttcga aacccctatc 1740 ctggccagat atgtgcgcat tctgcccgtg gcctggcaca acagaattgc cctgagactg 1800 gaactgctgg gatgc 1815 <210> 127 <211> 227 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 127 Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 1 5 10 15 Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 20 25 30 Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Val Ser His 35 40 45 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 50 55 60 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 65 70 75 80 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 85 90 95 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile 100 105 110 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 115 120 125 Tyr Thr Leu Pro Pro Cys Arg Glu Glu Met Thr Lys Asn Gln Val Ser 130 135 140 Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 145 150 155 160 Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 165 170 175 Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 180 185 190 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 195 200 205 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 210 215 220 Pro Gly Lys 225 <210> 128 <211> 681 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 128 gataagaccc acacctgtcc tccatgtcct gctccagaac tgctcggcgg accctccgtt 60 ttcctgtttc cacctaagcc taaggacacc ctgatgatca gcagaacccc tgaagtgacc 120 tgtgtggtgg tggccgtgtc tcacgaagat cccgaagtga agttcaattg gtacgtggac 180 ggcgtggaag tgcacaacgc caagaccaag cctagagagg aacagtacaa cagcacctac 240 agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag 300 tgcaaggtgt ccaacaaggc cctggccgct cctatcgaga aaaccatctc taaggccaag 360 ggccagcctc gggaacctca ggtttacacc ctgcctccat gccgggaaga gatgaccaag 420 aatcaggtgt ccctgtggtg cctggtcaag ggcttctacc cttccgatat cgccgtggaa 480 tgggagagca atggccagcc tgagaacaac tacaagacca cacctcctgt gctggacagc 540 gacggctcat tcttcctgta cagcaagctg acagtggaca agagcagatg gcagcagggc 600 aacgtgttca gctgttctgt gatgcacgag gccctgcaca accactacac ccagaagtct 660 ctgtctctga gccccggcaa a 681 <210> 129 <211> 605 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 129 Leu Asp Ile Cys Ser Lys Asn Pro Cys His Asn Gly Gly Leu Cys Glu 1 5 10 15 Glu Ile Ser Gln Glu Val Arg Gly Asp Val Phe Pro Ser Tyr Thr Cys 20 25 30 Thr Cys Leu Lys Gly Tyr Ala Gly Asn His Cys Glu Thr Lys Gly Ser 35 40 45 Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 50 55 60 Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 65 70 75 80 Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Val Ser His 85 90 95 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 100 105 110 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 115 120 125 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 130 135 140 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile 145 150 155 160 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 165 170 175 Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 180 185 190 Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 195 200 205 Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 210 215 220 Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 225 230 235 240 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 245 250 255 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 260 265 270 Pro Gly Lys Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Cys 275 280 285 Val Glu Pro Leu Gly Met Glu Asn Gly Asn Ile Ala Asn Ser Gln Ile 290 295 300 Ala Ala Ser Ser Val Arg Val Thr Phe Leu Gly Leu Gln His Trp Val 305 310 315 320 Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly Met Val Asn Ala Trp Thr 325 330 335 Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile Gln Val Asn Leu Leu Arg 340 345 350 Arg Met Trp Val Thr Gly Val Val Thr Gln Gly Ala Ser Arg Leu Ala 355 360 365 Ser His Glu Tyr Leu Lys Ala Phe Lys Val Ala Tyr Ser Leu Asn Gly 370 375 380 His Glu Phe Asp Phe Ile His Asp Val Asn Lys Lys His Lys Glu Phe 385 390 395 400 Val Gly Asn Trp Asn Lys Asn Ala Val His Val Asn Leu Phe Glu Thr 405 410 415 Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr Pro Thr Ser Cys His Thr 420 425 430 Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly Cys Glu Leu Asn Gly Cys 435 440 445 Ala Asn Pro Leu Gly Leu Lys Asn Asn Ser Ile Pro Asp Lys Gln Ile 450 455 460 Thr Ala Ser Ser Ser Tyr Lys Thr Trp Gly Leu His Leu Phe Ser Trp 465 470 475 480 Asn Pro Ser Tyr Ala Arg Leu Asp Lys Gln Gly Asn Phe Asn Ala Trp 485 490 495 Val Ala Gly Ser Tyr Gly Asn Asp Gln Trp Leu Gln Val Asp Leu Gly 500 505 510 Ser Ser Lys Glu Val Thr Gly Ile Ile Thr Gln Gly Ala Arg Asn Phe 515 520 525 Gly Ser Val Gln Phe Val Ala Ser Tyr Lys Val Ala Tyr Ser Asn Asp 530 535 540 Ser Ala Asn Trp Thr Glu Tyr Gln Asp Pro Arg Thr Gly Ser Ser Lys 545 550 555 560 Ile Phe Pro Gly Asn Trp Asp Asn His Ser His Lys Lys Asn Leu Phe 565 570 575 Glu Thr Pro Ile Leu Ala Arg Tyr Val Arg Ile Leu Pro Val Ala Trp 580 585 590 His Asn Arg Ile Ala Leu Arg Leu Glu Leu Leu Gly Cys 595 600 605 <210> 130 <211> 1815 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 130 ctggacatct gtagcaagaa cccttgccac aacggcggcc tgtgcgaaga gatttctcaa 60 gaagtgcggg gcgacgtttt ccccagctac acctgtacat gtctgaaggg ctacgccggc 120 aaccactgcg agacaaaggg cagcgataag acccacacct gtcctccatg tcctgctcca 180 gaactgctcg gcggaccctc cgttttcctg tttccaccta agcctaagga caccctgatg 240 atcagcagaa cccctgaagt gacctgtgtg gtggtggccg tgtctcacga agatcccgaa 300 gtgaagttca attggtacgt ggacggcgtg gaagtgcaca acgccaagac caagcctaga 360 gaggaacagt acaacagcac ctacagagtg gtgtccgtgc tgaccgtgct gcaccaggat 420 tggctgaacg gcaaagagta caagtgcaag gtgtccaaca aggccctggc cgctcctatc 480 gagaaaacca tctctaaggc caagggccag cctcgggaac ctcaagtctg tacactgcct 540 cctagccggg acgagctgac caaaaatcag gtgtccctga gctgcgccgt gaagggcttt 600 tacccttccg atatcgccgt ggaatgggag agcaatggcc agcctgagaa caactacaag 660 accacacctc ctgtgctgga cagcgacggc tcattctttc tggtgtccaa gctgacagtg 720 gacaagagca gatggcagca gggcaacgtg ttcagctgtt ctgtgatgca cgaggccctg 780 cacaaccact acacccagaa gtctctgtct ctgagccctg gcaaaggcgg aagcggtgga 840 agcggaggat ctggcggatc ttgtgtggaa cccctcggca tggaaaacgg caatatcgcc 900 aatagccaga tcgccgccag cagcgtcaga gtgacatttc tgggactgca acactgggtg 960 ccagagctgg ccagactgaa tagagccggc atggttaacg cctggacacc cagcagcaac 1020 gacgacaacc cctggattca agtgaacctg ctgcggcgta tgtgggtcac aggtgttgtt 1080 acacagggcg caagcagact ggccagccac gagtatctga aggcctttaa ggtggcctac 1140 agcctgaacg gccacgagtt cgacttcatc cacgacgtga acaagaagca caaagagttc 1200 gtcggcaact ggaacaagaa cgccgtgcac gtgaacctgt tcgagacacc tgtggaagcc 1260 cagtacgtgc ggctgtaccc tacaagctgt cacaccgcct gcacactgag attcgagctg 1320 ctgggctgcg agctgaatgg ctgtgctaat cctctgggcc tgaagaacaa tagcatcccc 1380 gacaagcaga tcaccgcctc cagcagctat aagacatggg gcctgcacct gtttagctgg 1440 aaccctagct acgccagact ggacaagcag ggaaacttca atgcctgggt ggccggcagc 1500 tacggcaatg atcaatggct gcaagtggac ctgggcagca gcaaagaagt gaccggcatc 1560 attacccagg gcgctagaaa tttcggcagc gtgcagttcg tggccagcta caaagtggcc 1620 tactccaacg acagcgccaa ctggaccgag tatcaggacc ctagaaccgg cagctccaag 1680 atcttccccg gcaattggga caaccacagc cacaagaaga atctgttcga aacccctatc 1740 ctggccagat atgtgcgcat tctgcccgtg gcctggcaca acagaattgc cctgagactg 1800 gaactgctgg gatgc 1815 <210> 131 <211> 783 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 131 Leu Asp Ile Cys Ser Lys Asn Pro Cys His Asn Gly Gly Leu Cys Glu 1 5 10 15 Glu Ile Ser Gln Glu Val Arg Gly Glu Val Phe Pro Ser Tyr Thr Cys 20 25 30 Thr Cys Leu Lys Gly Tyr Ala Gly Asn His Cys Glu Thr Lys Asp Ala 35 40 45 His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn 50 55 60 Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Ser 65 70 75 80 Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala 85 90 95 Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu 100 105 110 His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu 115 120 125 Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg 130 135 140 Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg 145 150 155 160 Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn 165 170 175 Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His 180 185 190 Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys 195 200 205 Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu 210 215 220 Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala 225 230 235 240 Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala 245 250 255 Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala 260 265 270 Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His 275 280 285 Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala 290 295 300 Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys 305 310 315 320 Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile 325 330 335 Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala 340 345 350 Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala 355 360 365 Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His 370 375 380 Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu 385 390 395 400 Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr 405 410 415 Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn 420 425 430 Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys 435 440 445 Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val 450 455 460 Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly 465 470 475 480 Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu 485 490 495 Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys 500 505 510 Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val 515 520 525 Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val 530 535 540 Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys 545 550 555 560 Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val 565 570 575 Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala 580 585 590 Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp 595 600 605 Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Cys 610 615 620 Val Glu Pro Leu Gly Met Glu Asn Gly Asn Ile Ala Asn Ser Gln Ile 625 630 635 640 Ala Ala Ser Ser Val Arg Val Thr Phe Leu Gly Leu Gln His Trp Val 645 650 655 Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly Met Val Asn Ala Trp Thr 660 665 670 Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile Gln Val Asn Leu Leu Arg 675 680 685 Arg Met Trp Val Thr Gly Val Val Thr Gln Gly Ala Ser Arg Leu Ala 690 695 700 Ser His Glu Tyr Leu Lys Ala Phe Lys Val Ala Tyr Ser Leu Asn Gly 705 710 715 720 His Glu Phe Asp Phe Ile His Asp Val Asn Lys Lys His Lys Glu Phe 725 730 735 Val Gly Asn Trp Asn Lys Asn Ala Val His Val Asn Leu Phe Glu Thr 740 745 750 Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr Pro Thr Ser Cys His Thr 755 760 765 Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly Cys Glu Leu Asn Gly 770 775 780 <210> 132 <211> 2349 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 132 ctggacatct gtagcaagaa cccttgccac aacggcggcc tgtgcgaaga gatcagtcaa 60 gaagtgcggg gcgaagtctt tcccagctac acctgtacct gtctgaaggg ctatgccggc 120 aaccactgcg agacaaagga tgcccacaag agcgaggtgg cccacagatt caaggatctg 180 ggcgaagaga acttcaaggc cctggtgctg atcgccttcg ctcagtatct ccagcagagc 240 cctttcgagg accacgtgaa gctggtcaac gaagtgaccg agttcgccaa gacctgtgtg 300 gccgatgaga gcgccgagaa ctgtgataag agcctgcaca ccctgttcgg cgacaagctg 360 tgtacagtgg ccacactgag agaaacctac ggcgagatgg ccgactgctg tgccaagcaa 420 gagcccgaga gaaacgagtg cttcctccag cacaaggacg acaaccccaa cctgcctaga 480 ctcgtgcgac ccgaagtgga tgtgatgtgc accgcctttc acgacaacga ggaaaccttc 540 ctgaagaagt acctgtacga gatcgccaga cggcacccct acttttatgc ccctgagctg 600 ctgttcttcg ccaagcggta taaggccgcc ttcaccgaat gttgccaggc cgctgataag 660 gctgcctgtc tgctgcctaa gctggacgag ctgagagatg agggcaaagc cagctctgcc 720 aagcagagac tgaaatgcgc cagcctccag aagttcggcg agagagcttt taaggcctgg 780 gccgttgcca gactgagcca gagatttcct aaggccgagt ttgccgaggt gtccaagctc 840 gtgaccgatc tgacaaaggt gcacaccgag tgctgtcacg gcgatctgct ggaatgtgcc 900 gacgatagag ccgacctggc caagtacatc tgcgagaacc aggacagcat cagcagcaag 960 ctgaaagagt gctgcgagaa gcccctgctg gaaaagtctc actgtatcgc cgaggtggaa 1020 aacgacgaga tgcctgccga tctgcctagc ctggctgccg atttcgtgga aagcaaggac 1080 gtgtgcaaga actacgccga ggccaaggat gtgtttctgg gcatgtttct gtatgagtac 1140 gcccgcagac accccgacta ttctgtggtt ctgctgctgc ggctggccaa aacctacgag 1200 acaaccctgg aaaaatgctg cgccgctgcc gatcctcacg agtgttatgc caaggtgttc 1260 gacgagttca agcctctggt ggaagaaccc cagaacctga tcaagcagaa ctgcgagctg 1320 ttcgagcagc tgggcgagta caagttccag aatgccctgc tcgtgcggta caccaagaaa 1380 gtgcctcagg tgtccacacc tacactggtt gaggtgtccc ggaatctggg caaagtgggc 1440 agcaagtgtt gcaagcaccc tgaggccaag agaatgcctt gcgccgagga ttatctgagc 1500 gtggtgctga atcagctgtg cgtgctgcac gagaaaaccc ctgtgtccga cagagtgacc 1560 aagtgctgta ccgagagcct cgtgaacaga aggccttgct ttagcgccct ggaagtggac 1620 gagacatacg tgcccaaaga gttcaacgcc gagacattca ccttccacgc cgacatctgc 1680 accctgtccg agaaagagcg gcagatcaag aagcagacag ccctggtcga gctggttaag 1740 cacaagccca aggccaccaa agaacagctg aaggccgtga tggacgactt cgccgccttt 1800 gtcgagaagt gctgcaaggc cgacgacaaa gagacatgct tcgccgaaga gggcaagaaa 1860 ctggtggcct gtgtggaacc cctcggcatg gaaaacggca atatcgccaa tagccagatt 1920 gccgccagca gcgtcagagt gacatttctg ggactgcaac actgggtgcc cgagctggct 1980 agactgaata gagccggcat ggtcaacgcc tggacaccca gcagcaacga cgataatccc 2040 tggattcaag tgaacctgct gcggcgtatg tgggtcacag gtgttgttac acagggcgca 2100 agcagactgg ccagccacga gtatctgaag gcctttaagg tggcctacag cctgaacggc 2160 cacgagttcg acttcatcca cgacgtgaac aagaagcaca aagagtttgt cggcaactgg 2220 aacaagaacg ccgtgcacgt gaacctgttc gagacacctg tggaagccca gtacgtgcgg 2280 ctgtacccta caagctgtca caccgcctgc actctgagat tcgaactgct gggatgcgag 2340 ctgaacggc 2349 <210> 133 <211> 872 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 133 Asp Ile Cys Asp Pro Asn Pro Cys Glu Asn Gly Gly Ile Cys Leu Pro 1 5 10 15 Gly Leu Ala Asp Gly Ser Phe Ser Cys Glu Cys Pro Asp Gly Phe Thr 20 25 30 Asp Pro Asn Cys Ser Ser Val Val Glu Val Ala Ser Asp Glu Glu Glu 35 40 45 Pro Thr Ser Ala Gly Pro Cys Thr Pro Asn Pro Cys His Asn Gly Gly 50 55 60 Thr Cys Glu Ile Ser Glu Ala Tyr Arg Gly Asp Thr Phe Ile Gly Tyr 65 70 75 80 Val Cys Lys Cys Pro Arg Gly Phe Asn Gly Ile His Cys Gln His Asn 85 90 95 Ile Asn Glu Cys Glu Val Glu Pro Cys Lys Asn Gly Gly Ile Cys Thr 100 105 110 Asp Leu Val Ala Asn Tyr Ser Cys Glu Cys Pro Gly Glu Phe Met Gly 115 120 125 Arg Asn Cys Gln Tyr Lys Asp Ala His Lys Ser Glu Val Ala His Arg 130 135 140 Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala 145 150 155 160 Phe Ala Gln Tyr Leu Gln Gln Ser Pro Phe Glu Asp His Val Lys Leu 165 170 175 Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser 180 185 190 Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu 195 200 205 Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys 210 215 220 Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys 225 230 235 240 Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val 245 250 255 Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr 260 265 270 Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu 275 280 285 Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln 290 295 300 Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg 305 310 315 320 Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser 325 330 335 Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg 340 345 350 Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu 355 360 365 Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu 370 375 380 Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu 385 390 395 400 Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro 405 410 415 Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met 420 425 430 Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp 435 440 445 Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe 450 455 460 Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu 465 470 475 480 Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala 485 490 495 Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys 500 505 510 Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu 515 520 525 Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg 530 535 540 Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val 545 550 555 560 Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu 565 570 575 Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn 580 585 590 Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr 595 600 605 Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala 610 615 620 Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr 625 630 635 640 Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln 645 650 655 Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys 660 665 670 Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe 675 680 685 Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu 690 695 700 Glu Gly Lys Lys Leu Val Ala Cys Ser Gly Pro Leu Gly Ile Glu Gly 705 710 715 720 Gly Ile Ile Ser Asn Gln Gln Ile Thr Ala Ser Ser Thr His Arg Ala 725 730 735 Leu Phe Gly Leu Gln Lys Trp Tyr Pro Tyr Tyr Ala Arg Leu Asn Lys 740 745 750 Lys Gly Leu Ile Asn Ala Trp Thr Ala Ala Glu Asn Asp Arg Trp Pro 755 760 765 Trp Ile Gln Ile Asn Leu Gln Arg Lys Met Arg Val Thr Gly Val Ile 770 775 780 Thr Gln Gly Ala Lys Arg Ile Gly Ser Pro Glu Tyr Ile Lys Ser Tyr 785 790 795 800 Lys Ile Ala Tyr Ser Asn Asp Gly Lys Thr Trp Ala Met Tyr Lys Val 805 810 815 Lys Gly Thr Asn Glu Asp Met Val Phe Arg Gly Asn Ile Asp Asn Asn 820 825 830 Thr Pro Tyr Ala Asn Ser Phe Thr Pro Pro Ile Lys Ala Gln Tyr Val 835 840 845 Arg Leu Tyr Pro Gln Val Cys Arg Arg His Cys Thr Leu Arg Met Glu 850 855 860 Leu Leu Gly Cys Glu Leu Ser Gly 865 870 <210> 134 <211> 2616 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 134 gacatctgcg accccaatcc ttgcgagaat ggcggcattt gtctgcctgg actggccgat 60 ggcagcttct cttgtgaatg ccccgatggc ttcacagacc ccaattgcag ctctgtggtg 120 gaagtggcca gcgacgagga agaacctaca agcgctggcc cctgcacacc caatccatgt 180 cataatggcg gaacctgcga gatcagcgag gcctacagag gcgatacctt catcggctac 240 gtgtgcaagt gccccagagg cttcaatggc atccactgcc agcacaacat caacgagtgc 300 gaggtggaac catgcaagaa cggcggcatc tgtaccgacc tggtggccaa ttactcttgc 360 gagtgccctg gcgagttcat gggcagaaac tgccagtaca aggacgccca caagagcgag 420 gtggcccaca gattcaagga cctgggcgaa gagaacttca aggccctggt gctgatcgcc 480 ttcgctcagt atctccagca gagccctttc gaggaccacg tgaagctggt caacgaagtg 540 accgagttcg ccaagacctg tgtggccgat gagagcgccg agaactgtga caagagcctg 600 cacacactgt tcggcgacaa gctgtgtacc gtggccacac tgagagaaac ctacggcgag 660 atggccgact gctgtgccaa gcaagagccc gagagaaacg agtgcttcct ccagcacaag 720 gatgacaacc ccaacctgcc tagactcgtg cggcctgaag tggatgtgat gtgcaccgcc 780 tttcacgaca acgaggaaac cttcctgaag aagtacctgt acgagatcgc cagacggcac 840 ccctactttt atgcccctga gctgctgttc ttcgccaagc ggtataaggc cgccttcacc 900 gaatgttgcc aggccgctga taaggctgcc tgtctgctgc ctaagctgga cgagctgaga 960 gatgagggca aagccagctc tgccaagcag agactgaaat gcgccagcct ccagaagttc 1020 ggcgagagag cttttaaggc ctgggccgtt gccagactga gccagagatt tcctaaggcc 1080 gagtttgccg aggtgtccaa gctcgtgacc gatctgacaa aggtgcacac cgagtgctgt 1140 cacggcgatc tgctggaatg tgccgacgat agagccgacc tggccaagta tatctgcgag 1200 aaccaggaca gcatcagcag caagctgaaa gagtgctgcg agaagcccct gctggaaaag 1260 tctcactgta tcgccgaagt ggaaaacgac gagatgcccg ccgatctgcc ttctctggct 1320 gccgatttcg tggaaagcaa ggatgtgtgc aagaactacg ccgaggccaa agatgtgttt 1380 ctgggcatgt ttctgtatga gtacgcccgc agacaccccg actattctgt ggttctgctg 1440 ctgcggctgg ccaagacata cgagacaacc ctggaaaaat gctgcgccgc tgccgatcct 1500 cacgagtgtt atgccaaggt gttcgacgag ttcaagccac tggtggaaga accccagaac 1560 ctgatcaagc agaactgcga gctgttcgag cagctgggcg agtacaagtt ccagaatgcc 1620 ctgctcgtgc ggtacaccaa gaaagtgcct caggtgtcca cacctacact ggttgaggtg 1680 tcccggaatc tgggcaaagt gggcagcaag tgttgcaagc accctgaggc caagagaatg 1740 ccttgcgccg aggattacct gagcgtggtg ctgaatcagc tgtgcgtgct gcacgagaaa 1800 acccctgtgt ccgacagagt gaccaagtgc tgtaccgaga gcctcgtgaa cagaaggcct 1860 tgctttagcg ccctggaagt ggacgagaca tacgtgccca aagagttcaa cgccgagaca 1920 ttcaccttcc acgccgatat ctgcaccctg tccgagaaag agcggcagat caagaagcag 1980 acagccctgg tcgagctggt taagcacaag cccaaggcca ccaaagaaca gctgaaggcc 2040 gtgatggacg acttcgccgc ctttgtcgag aagtgctgca aggccgacga caaagagaca 2100 tgcttcgccg aagagggcaa gaaactggtg gcctgttctg gccctctggg catcgaaggc 2160 ggcatcatca gcaatcagca gatcaccgcc agcagcaccc acagagcact gtttggcctg 2220 caaaagtggt atccctacta cgcccggctg aacaagaagg gcctgattaa cgcctggaca 2280 gccgccgaga atgacagatg gccctggatt cagatcaacc tccagcggaa gatgagagtg 2340 accggcgtta tcacacaggg cgcaaagaga atcggctccc ctgagtacat caagagctac 2400 aagatcgcct acagcaacga cggcaagacc tgggccatgt acaaagtgaa gggcaccaac 2460 gaggacatgg tgttccgggg caacatcgac aacaacaccc cttacgccaa cagcttcacc 2520 cctcctatca aggcccagta cgtgcggctg taccctcaag tgtgcagaag gcactgtacc 2580 ctgagaatgg aactgctggg ctgcgaactg tctggc 2616 <210> 135 <211> 869 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 135 Asp Ile Cys Asp Pro Asn Pro Cys Glu Asn Gly Gly Ile Cys Leu Pro 1 5 10 15 Gly Leu Ala Asp Gly Ser Phe Ser Cys Glu Cys Pro Asp Gly Phe Thr 20 25 30 Asp Pro Asn Cys Ser Ser Val Val Glu Val Ala Ser Asp Glu Glu Glu 35 40 45 Pro Thr Ser Ala Gly Pro Cys Thr Pro Asn Pro Cys His Asn Gly Gly 50 55 60 Thr Cys Glu Ile Ser Glu Ala Tyr Arg Gly Asp Thr Phe Ile Gly Tyr 65 70 75 80 Val Cys Lys Cys Pro Arg Gly Phe Asn Gly Ile His Cys Gln His Asn 85 90 95 Ile Asn Glu Cys Glu Val Glu Pro Cys Lys Asn Gly Gly Ile Cys Thr 100 105 110 Asp Leu Val Ala Asn Tyr Ser Cys Glu Cys Pro Gly Glu Phe Met Gly 115 120 125 Arg Asn Cys Gln Tyr Lys Asp Ala His Lys Ser Glu Val Ala His Arg 130 135 140 Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala 145 150 155 160 Phe Ala Gln Tyr Leu Gln Gln Ser Pro Phe Glu Asp His Val Lys Leu 165 170 175 Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser 180 185 190 Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu 195 200 205 Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys 210 215 220 Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys 225 230 235 240 Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val 245 250 255 Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr 260 265 270 Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu 275 280 285 Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln 290 295 300 Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg 305 310 315 320 Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser 325 330 335 Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg 340 345 350 Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu 355 360 365 Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu 370 375 380 Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu 385 390 395 400 Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro 405 410 415 Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met 420 425 430 Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp 435 440 445 Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe 450 455 460 Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu 465 470 475 480 Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala 485 490 495 Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys 500 505 510 Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu 515 520 525 Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg 530 535 540 Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val 545 550 555 560 Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu 565 570 575 Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn 580 585 590 Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr 595 600 605 Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala 610 615 620 Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr 625 630 635 640 Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln 645 650 655 Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys 660 665 670 Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe 675 680 685 Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu 690 695 700 Glu Gly Lys Lys Leu Val Ala Cys Ser Glu Pro Leu Gly Met Lys Ser 705 710 715 720 Gly His Ile Gln Asp Tyr Gln Ile Thr Ala Ser Ser Ile Phe Arg Thr 725 730 735 Leu Asn Met Asp Met Phe Thr Trp Glu Pro Arg Lys Ala Arg Leu Asp 740 745 750 Lys Gln Gly Lys Val Asn Ala Trp Thr Ser Gly His Asn Asp Gln Ser 755 760 765 Gln Trp Leu Gln Val Asp Leu Leu Val Pro Thr Lys Val Thr Gly Ile 770 775 780 Ile Thr Gln Gly Ala Lys Asp Phe Gly His Val Gln Phe Val Gly Ser 785 790 795 800 Tyr Lys Leu Ala Tyr Ser Asn Asp Gly Glu His Trp Thr Val Tyr Gln 805 810 815 Asp Glu Lys Gln Arg Lys Asp Lys Val Phe Gln Gly Asn Phe Asp Asn 820 825 830 Asp Thr His Arg Lys Asn Val Ile Asp Pro Pro Ile Tyr Ala Arg His 835 840 845 Ile Arg Ile Leu Pro Trp Ser Trp Tyr Gly Arg Ile Thr Leu Arg Ser 850 855 860 Glu Leu Leu Gly Cys 865 <210> 136 <211> 2607 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 136 gacatctgcg accccaatcc ttgcgagaat ggcggcattt gtctgcctgg actggccgat 60 ggcagcttct cttgtgaatg ccccgatggc ttcacagacc ccaattgcag ctctgtggtg 120 gaagtggcca gcgacgagga agaacctaca agcgctggcc cctgcacacc caatccatgt 180 cataatggcg gaacctgcga gatcagcgag gcctacagag gcgatacctt catcggctac 240 gtgtgcaagt gccccagagg cttcaatggc atccactgcc agcacaacat caacgagtgc 300 gaggtggaac catgcaagaa cggcggcatc tgtaccgacc tggtggccaa ttactcttgc 360 gagtgccctg gcgagttcat gggcagaaac tgccagtaca aggacgccca caagagcgag 420 gtggcccaca gattcaagga cctgggcgaa gagaacttca aggccctggt gctgatcgcc 480 ttcgctcagt atctccagca gagccctttc gaggaccacg tgaagctggt caacgaagtg 540 accgagttcg ccaagacctg tgtggccgat gagagcgccg agaactgtga caagagcctg 600 cacacactgt tcggcgacaa gctgtgtacc gtggccacac tgagagaaac ctacggcgag 660 atggccgact gctgtgccaa gcaagagccc gagagaaacg agtgcttcct ccagcacaag 720 gatgacaacc ccaacctgcc tagactcgtg cggcctgaag tggatgtgat gtgcaccgcc 780 tttcacgaca acgaggaaac cttcctgaag aagtacctgt acgagatcgc cagacggcac 840 ccctactttt atgcccctga gctgctgttc ttcgccaagc ggtataaggc cgccttcacc 900 gaatgttgcc aggccgctga taaggctgcc tgtctgctgc ctaagctgga cgagctgaga 960 gatgagggca aagccagctc tgccaagcag agactgaaat gcgccagcct ccagaagttc 1020 ggcgagagag cttttaaggc ctgggccgtt gccagactga gccagagatt tcctaaggcc 1080 gagtttgccg aggtgtccaa gctcgtgacc gatctgacaa aggtgcacac cgagtgctgt 1140 cacggcgatc tgctggaatg tgccgacgat agagccgacc tggccaagta tatctgcgag 1200 aaccaggaca gcatcagcag caagctgaaa gagtgctgcg agaagcccct gctggaaaag 1260 tctcactgta tcgccgaagt ggaaaacgac gagatgcccg ccgatctgcc ttctctggct 1320 gccgatttcg tggaaagcaa ggatgtgtgc aagaactacg ccgaggccaa agatgtgttt 1380 ctgggcatgt ttctgtatga gtacgcccgc agacaccccg actattctgt ggttctgctg 1440 ctgcggctgg ccaagacata cgagacaacc ctggaaaaat gctgcgccgc tgccgatcct 1500 cacgagtgtt atgccaaggt gttcgacgag ttcaagccac tggtggaaga accccagaac 1560 ctgatcaagc agaactgcga gctgttcgag cagctgggcg agtacaagtt ccagaatgcc 1620 ctgctcgtgc ggtacaccaa gaaagtgcct caggtgtcca cacctacact ggttgaggtg 1680 tcccggaatc tgggcaaagt gggcagcaag tgttgcaagc accctgaggc caagagaatg 1740 ccttgcgccg aggattacct gagcgtggtg ctgaatcagc tgtgcgtgct gcacgagaaa 1800 acccctgtgt ccgacagagt gaccaagtgc tgtaccgaga gcctcgtgaa cagaaggcct 1860 tgctttagcg ccctggaagt ggacgagaca tacgtgccca aagagttcaa cgccgagaca 1920 ttcaccttcc acgccgatat ctgcaccctg tccgagaaag agcggcagat caagaagcag 1980 acagccctgg tcgagctggt taagcacaag cccaaggcca ccaaagaaca gctgaaggcc 2040 gtgatggacg acttcgccgc ctttgtcgag aagtgctgca aggccgacga caaagagaca 2100 tgcttcgccg aagagggcaa gaaactggtg gcctgttctg agccactggg catgaagtct 2160 ggccacatcc aggattacca gatcaccgcc agcagcatct tcagaaccct gaacatggat 2220 atgttcacct gggagccccg gaaggccaga ctggataagc agggaaaagt gaacgcctgg 2280 accagcggcc acaatgacca gtctcagtgg ctgcaagtgg acctgctggt gcctaccaaa 2340 gtgaccggca tcatcacaca gggcgcaaag gatttcggcc acgtgcagtt tgtgggcagc 2400 tacaagctgg cctacagcaa cgatggcgag cactggacag tgtaccagga cgagaagcag 2460 cggaaggata aggtgttcca gggcaacttc gacaacgaca cccaccggaa gaacgtgatc 2520 gaccctccta tctacgcccg gcacatcaga atcctgcctt ggtcttggta cggccggatc 2580 accctgagaa gcgagctgct tggatgt 2607 <210> 137 <211> 781 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 137 Leu Asp Ile Cys Ser Lys Asn Pro Cys His Asn Gly Gly Leu Cys Glu 1 5 10 15 Glu Ile Ser Gln Glu Val Arg Gly Asp Val Phe Pro Ser Tyr Thr Cys 20 25 30 Thr Cys Leu Lys Gly Tyr Ala Gly Asn His Cys Glu Thr Lys Asp Ala 35 40 45 His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn 50 55 60 Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Ser 65 70 75 80 Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala 85 90 95 Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu 100 105 110 His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu 115 120 125 Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg 130 135 140 Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg 145 150 155 160 Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn 165 170 175 Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His 180 185 190 Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys 195 200 205 Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu 210 215 220 Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala 225 230 235 240 Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala 245 250 255 Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala 260 265 270 Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His 275 280 285 Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala 290 295 300 Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys 305 310 315 320 Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile 325 330 335 Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala 340 345 350 Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala 355 360 365 Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His 370 375 380 Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu 385 390 395 400 Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr 405 410 415 Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn 420 425 430 Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys 435 440 445 Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val 450 455 460 Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly 465 470 475 480 Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu 485 490 495 Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys 500 505 510 Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val 515 520 525 Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val 530 535 540 Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys 545 550 555 560 Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val 565 570 575 Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala 580 585 590 Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp 595 600 605 Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Cys 610 615 620 Ala Asn Pro Leu Gly Leu Lys Asn Asn Ser Ile Pro Asp Lys Gln Ile 625 630 635 640 Thr Ala Ser Ser Ser Tyr Lys Thr Trp Gly Leu His Leu Phe Ser Trp 645 650 655 Asn Pro Ser Tyr Ala Arg Leu Asp Lys Gln Gly Asn Phe Asn Ala Trp 660 665 670 Val Ala Gly Ser Tyr Gly Asn Asp Gln Trp Leu Gln Val Asp Leu Gly 675 680 685 Ser Ser Lys Glu Val Thr Gly Ile Ile Thr Gln Gly Ala Arg Asn Phe 690 695 700 Gly Ser Val Gln Phe Val Ala Ser Tyr Lys Val Ala Tyr Ser Asn Asp 705 710 715 720 Ser Ala Asn Trp Thr Glu Tyr Gln Asp Pro Arg Thr Gly Ser Ser Lys 725 730 735 Ile Phe Pro Gly Asn Trp Asp Asn His Ser His Lys Lys Asn Leu Phe 740 745 750 Glu Thr Pro Ile Leu Ala Arg Tyr Val Arg Ile Leu Pro Val Ala Trp 755 760 765 His Asn Arg Ile Ala Leu Arg Leu Glu Leu Leu Gly Cys 770 775 780 <210> 138 <211> 2343 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 138 ctggacatct gtagcaagaa cccttgccac aacggcggcc tgtgcgaaga gatttctcaa 60 gaagtgcggg gcgacgtttt ccccagctac acctgtacat gtctgaaggg ctacgccggc 120 aaccactgcg agacaaagga tgcccacaag agcgaggtgg cccacagatt caaggatctg 180 ggcgaagaga acttcaaggc cctggtgctg atcgccttcg ctcagtatct ccagcagagc 240 cctttcgagg accacgtgaa gctggtcaac gaagtgaccg agttcgccaa gacctgtgtg 300 gccgatgaga gcgccgagaa ctgtgataag agcctgcaca ccctgttcgg cgacaagctg 360 tgtacagtgg ccacactgag agaaacctac ggcgagatgg ccgactgctg tgccaagcaa 420 gagcccgaga gaaacgagtg cttcctccag cacaaggacg acaaccccaa cctgcctaga 480 ctcgtgcgac ccgaagtgga tgtgatgtgc accgcctttc acgacaacga ggaaaccttc 540 ctgaagaagt acctgtacga gatcgccaga cggcacccct acttttatgc ccctgagctg 600 ctgttcttcg ccaagcggta taaggccgcc ttcaccgaat gttgccaggc cgctgataag 660 gctgcctgtc tgctgcctaa gctggacgag ctgagagatg agggcaaagc cagctctgcc 720 aagcagagac tgaaatgcgc cagcctccag aagttcggcg agagagcttt taaggcctgg 780 gccgttgcca gactgagcca gagatttcct aaggccgagt ttgccgaggt gtccaagctc 840 gtgaccgatc tgacaaaggt gcacaccgag tgctgtcacg gcgatctgct ggaatgtgcc 900 gacgatagag ccgacctggc caagtacatc tgcgagaacc aggacagcat cagcagcaag 960 ctgaaagagt gctgcgagaa gcccctgctg gaaaagtctc actgtatcgc cgaggtggaa 1020 aacgacgaga tgcctgccga tctgcctagc ctggctgccg atttcgtgga aagcaaggac 1080 gtgtgcaaga actacgccga ggccaaggat gtgtttctgg gcatgtttct gtatgagtac 1140 gcccgcagac accccgacta ttctgtggtt ctgctgctgc ggctggccaa aacctacgag 1200 acaaccctgg aaaaatgctg cgccgctgcc gatcctcacg agtgttatgc caaggtgttc 1260 gacgagttca agcctctggt ggaagaaccc cagaacctga tcaagcagaa ctgcgagctg 1320 ttcgagcagc tgggcgagta caagttccag aatgccctgc tcgtgcggta caccaagaaa 1380 gtgcctcagg tgtccacacc tacactggtt gaggtgtccc ggaatctggg caaagtgggc 1440 agcaagtgtt gcaagcaccc tgaggccaag agaatgcctt gcgccgagga ttacctgagc 1500 gtggtgctga atcagctgtg cgtgctgcac gagaaaaccc ctgtgtccga cagagtgacc 1560 aagtgctgta ccgagagcct cgtgaacaga aggccttgct ttagcgccct ggaagtggac 1620 gagacatacg tgcccaaaga gttcaacgcc gagacattca ccttccacgc cgacatctgc 1680 accctgtccg agaaagagcg gcagatcaag aagcagacag ccctggtcga gctggttaag 1740 cacaagccca aggccaccaa agaacagctg aaggccgtga tggacgactt cgccgccttt 1800 gtcgagaagt gctgcaaggc cgacgacaaa gagacatgct tcgccgaaga gggcaagaaa 1860 ctggtggcct gtgctaaccc tctgggcctg aagaacaaca gcatccccga taagcagatc 1920 accgccagca gcagctataa gacatggggc ctgcacctgt tcagctggaa cccttcttac 1980 gccagactgg acaagcaggg caacttcaat gcttgggtgg ccggcagcta cggcaatgat 2040 cagtggctgc aagtggacct gggcagcagc aaagaagtga caggcatcat cacccagggc 2100 gcaagaaatt tcggcagcgt gcagttcgtg gccagctaca aggtggccta cagcaacgat 2160 agcgccaact ggaccgagta tcaggaccct agaaccggca gctccaagat cttccccggc 2220 aactgggaca accacagcca caagaagaat ctgttcgaga cacccatcct ggccagatac 2280 gtgcggattc tgcctgtggc ctggcacaac agaatcgccc tgagactgga actgctgggc 2340 tgt 2343 <210> 139 <211> 623 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 139 Leu Asp Ile Cys Ser Lys Asn Pro Cys His Asn Gly Gly Leu Cys Glu 1 5 10 15 Glu Ile Ser Gln Glu Val Arg Gly Asp Val Phe Pro Ser Tyr Thr Cys 20 25 30 Thr Cys Leu Lys Gly Tyr Ala Gly Asn His Cys Glu Thr Lys Asp Ala 35 40 45 His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn 50 55 60 Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Ser 65 70 75 80 Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala 85 90 95 Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu 100 105 110 His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu 115 120 125 Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg 130 135 140 Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg 145 150 155 160 Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn 165 170 175 Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His 180 185 190 Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys 195 200 205 Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu 210 215 220 Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala 225 230 235 240 Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala 245 250 255 Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala 260 265 270 Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His 275 280 285 Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala 290 295 300 Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys 305 310 315 320 Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile 325 330 335 Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala 340 345 350 Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala 355 360 365 Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His 370 375 380 Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu 385 390 395 400 Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr 405 410 415 Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn 420 425 430 Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys 435 440 445 Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val 450 455 460 Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly 465 470 475 480 Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu 485 490 495 Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys 500 505 510 Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val 515 520 525 Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val 530 535 540 Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys 545 550 555 560 Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val 565 570 575 Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala 580 585 590 Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp 595 600 605 Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala 610 615 620 <210> 140 <211> 1869 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 140 ctggacatct gtagcaagaa cccttgccac aacggcggcc tgtgcgaaga gatttctcaa 60 gaagtgcggg gcgacgtttt ccccagctac acctgtacat gtctgaaggg ctacgccggc 120 aaccactgcg agacaaagga tgcccacaag agcgaggtgg cccacagatt caaggatctg 180 ggcgaagaga acttcaaggc cctggtgctg atcgccttcg ctcagtatct ccagcagagc 240 cctttcgagg accacgtgaa gctggtcaac gaagtgaccg agttcgccaa gacctgtgtg 300 gccgatgaga gcgccgagaa ctgtgataag agcctgcaca ccctgttcgg cgacaagctg 360 tgtacagtgg ccacactgag agaaacctac ggcgagatgg ccgactgctg tgccaagcaa 420 gagcccgaga gaaacgagtg cttcctccag cacaaggacg acaaccccaa cctgcctaga 480 ctcgtgcgac ccgaagtgga tgtgatgtgc accgcctttc acgacaacga ggaaaccttc 540 ctgaagaagt acctgtacga gatcgccaga cggcacccct acttttatgc ccctgagctg 600 ctgttcttcg ccaagcggta taaggccgcc ttcaccgaat gttgccaggc cgctgataag 660 gctgcctgtc tgctgcctaa gctggacgag ctgagagatg agggcaaagc cagctctgcc 720 aagcagagac tgaaatgcgc cagcctccag aagttcggcg agagagcttt taaggcctgg 780 gccgttgcca gactgagcca gagatttcct aaggccgagt ttgccgaggt gtccaagctc 840 gtgaccgatc tgacaaaggt gcacaccgag tgctgtcacg gcgatctgct ggaatgtgcc 900 gacgatagag ccgacctggc caagtacatc tgcgagaacc aggacagcat cagcagcaag 960 ctgaaagagt gctgcgagaa gcccctgctg gaaaagtctc actgtatcgc cgaggtggaa 1020 aacgacgaga tgcctgccga tctgcctagc ctggctgccg atttcgtgga aagcaaggac 1080 gtgtgcaaga actacgccga ggccaaggat gtgtttctgg gcatgtttct gtatgagtac 1140 gcccgcagac accccgacta ttctgtggtt ctgctgctgc ggctggccaa aacctacgag 1200 acaaccctgg aaaaatgctg cgccgctgcc gatcctcacg agtgttatgc caaggtgttc 1260 gacgagttca agcctctggt ggaagaaccc cagaacctga tcaagcagaa ctgcgagctg 1320 ttcgagcagc tgggcgagta caagttccag aatgccctgc tcgtgcggta caccaagaaa 1380 gtgcctcagg tgtccacacc tacactggtt gaggtgtccc ggaatctggg caaagtgggc 1440 agcaagtgtt gcaagcaccc tgaggccaag agaatgcctt gcgccgagga ttacctgagc 1500 gtggtgctga atcagctgtg cgtgctgcac gagaaaaccc ctgtgtccga cagagtgacc 1560 aagtgctgta ccgagagcct cgtgaacaga aggccttgct ttagcgccct ggaagtggac 1620 gagacatacg tgcccaaaga gttcaacgcc gagacattca ccttccacgc cgacatctgc 1680 accctgtccg agaaagagcg gcagatcaag aagcagacag ccctggtcga gctggttaag 1740 cacaagccca aggccaccaa agaacagctg aaggccgtga tggacgactt cgccgccttt 1800 gtcgagaagt gctgcaaggc cgacgacaaa gagacatgct tcgccgaaga gggcaagaaa 1860 ctggtggct 1869 <210> 141 <211> 160 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 141 Cys Val Glu Pro Leu Gly Leu Glu Asn Gly Asn Ile Ala Asn Ser Gln 1 5 10 15 Ile Ala Ala Ser Ser Val Arg Val Thr Phe Leu Gly Leu Gln His Trp 20 25 30 Val Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly Met Val Asn Ala Trp 35 40 45 Thr Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile Gln Val Asn Leu Leu 50 55 60 Arg Arg Met Trp Val Thr Gly Val Val Thr Gln Gly Ala Ser Arg Leu 65 70 75 80 Ala Ser His Glu Tyr Leu Lys Ala Phe Lys Val Ala Tyr Ser Leu Asn 85 90 95 Gly His Glu Phe Asp Phe Ile His Asp Val Asn Lys Lys His Lys Glu 100 105 110 Phe Val Gly Asn Trp Asn Lys Asn Ala Val His Val Asn Leu Phe Glu 115 120 125 Thr Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr Pro Thr Ser Cys His 130 135 140 Thr Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly Cys Glu Leu Asn Gly 145 150 155 160 <210> 142 <211> 160 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 142 Cys Val Glu Pro Leu Gly Met Glu Asn Gly Asn Ile Ala Asn Ser Gln 1 5 10 15 Ile Ala Ala Ser Ser Val Arg Val Thr Phe Leu Gly Leu Gln His Trp 20 25 30 Val Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly Met Val Asn Ala Trp 35 40 45 Thr Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile Gln Val Asn Leu Leu 50 55 60 Arg Arg Met Trp Val Thr Gly Val Val Thr Gln Gly Ala Ser Arg Leu 65 70 75 80 Ala Ser His Glu Tyr Leu Lys Ala Phe Lys Val Ala Tyr Ser Leu Asn 85 90 95 Gly His Glu Phe Asp Phe Ile His Asp Val Asn Lys Lys His Lys Glu 100 105 110 Phe Val Gly Asn Trp Asn Lys Asn Ala Val His Val Asn Leu Phe Glu 115 120 125 Thr Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr Pro Thr Ser Cys His 130 135 140 Thr Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly Cys Glu Leu Asn Gly 145 150 155 160 <210> 143 <211> 158 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 143 Cys Ala Asn Pro Leu Gly Leu Lys Asn Asn Ser Ile Pro Asp Lys Gln 1 5 10 15 Ile Thr Ala Ser Ser Ser Tyr Lys Thr Trp Gly Leu His Leu Phe Ser 20 25 30 Trp Asn Pro Ser Tyr Ala Arg Leu Asp Lys Gln Gly Asn Phe Asn Ala 35 40 45 Trp Val Ala Gly Ser Tyr Gly Asn Asp Gln Trp Leu Gln Val Asp Leu 50 55 60 Gly Ser Ser Lys Glu Val Thr Gly Ile Ile Thr Gln Gly Ala Arg Asn 65 70 75 80 Phe Gly Ser Val Gln Phe Val Ala Ser Tyr Lys Val Ala Tyr Ser Asn 85 90 95 Asp Ser Ala Asn Trp Thr Glu Tyr Gln Asp Pro Arg Thr Gly Ser Ser 100 105 110 Lys Ile Phe Pro Gly Asn Trp Asp Asn His Ser His Lys Lys Asn Leu 115 120 125 Phe Glu Thr Pro Ile Leu Ala Arg Tyr Val Arg Ile Leu Pro Val Ala 130 135 140 Trp His Asn Arg Ile Ala Leu Arg Leu Glu Leu Leu Gly Cys 145 150 155 <210> 144 <211> 161 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 144 Cys Ser Gly Pro Leu Gly Ile Glu Gly Gly Ile Ile Ser Asn Gln Gln 1 5 10 15 Ile Thr Ala Ser Ser Thr His Arg Ala Leu Phe Gly Leu Gln Lys Trp 20 25 30 Tyr Pro Tyr Tyr Ala Arg Leu Asn Lys Lys Gly Leu Ile Asn Ala Trp 35 40 45 Thr Ala Ala Glu Asn Asp Arg Trp Pro Trp Ile Gln Ile Asn Leu Gln 50 55 60 Arg Lys Met Arg Val Thr Gly Val Ile Thr Gln Gly Ala Lys Arg Ile 65 70 75 80 Gly Ser Pro Glu Tyr Ile Lys Ser Tyr Lys Ile Ala Tyr Ser Asn Asp 85 90 95 Gly Lys Thr Trp Ala Met Tyr Lys Val Lys Gly Thr Asn Glu Asp Met 100 105 110 Val Phe Arg Gly Asn Ile Asp Asn Asn Thr Pro Tyr Ala Asn Ser Phe 115 120 125 Thr Pro Pro Ile Lys Ala Gln Tyr Val Arg Leu Tyr Pro Gln Val Cys 130 135 140 Arg Arg His Cys Thr Leu Arg Met Glu Leu Leu Gly Cys Glu Leu Ser 145 150 155 160 Gly <210> 145 <211> 162 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 145 Cys Ser Glu Pro Leu Gly Met Lys Ser Gly His Ile Gln Asp Tyr Gln 1 5 10 15 Ile Thr Ala Ser Ser Ile Phe Arg Thr Leu Asn Met Asp Met Phe Thr 20 25 30 Trp Glu Pro Arg Lys Ala Arg Leu Asp Lys Gln Gly Lys Val Asn Ala 35 40 45 Trp Thr Ser Gly His Asn Asp Gln Ser Gln Trp Leu Gln Val Asp Leu 50 55 60 Leu Val Pro Thr Lys Val Thr Gly Ile Ile Thr Gln Gly Ala Lys Asp 65 70 75 80 Phe Gly His Val Gln Phe Val Gly Ser Tyr Lys Leu Ala Tyr Ser Asn 85 90 95 Asp Gly Glu His Trp Thr Val Tyr Gln Asp Glu Lys Gln Arg Lys Asp 100 105 110 Lys Val Phe Gln Gly Asn Phe Asp Asn Asp Thr His Arg Lys Asn Val 115 120 125 Ile Asp Pro Pro Ile Tyr Ala Arg His Ile Arg Ile Leu Pro Trp Ser 130 135 140 Trp Tyr Gly Arg Ile Thr Leu Arg Ser Glu Leu Leu Gly Cys Thr Glu 145 150 155 160 Glu Glu <210> 146 <211> 158 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 146 Cys Ser Glu Pro Leu Gly Met Lys Ser Gly His Ile Gln Asp Tyr Gln 1 5 10 15 Ile Thr Ala Ser Ser Ile Phe Arg Thr Leu Asn Met Asp Met Phe Thr 20 25 30 Trp Glu Pro Arg Lys Ala Arg Leu Asp Lys Gln Gly Lys Val Asn Ala 35 40 45 Trp Thr Ser Gly His Asn Asp Gln Ser Gln Trp Leu Gln Val Asp Leu 50 55 60 Leu Val Pro Thr Lys Val Thr Gly Ile Ile Thr Gln Gly Ala Lys Asp 65 70 75 80 Phe Gly His Val Gln Phe Val Gly Ser Tyr Lys Leu Ala Tyr Ser Asn 85 90 95 Asp Gly Glu His Trp Thr Val Tyr Gln Asp Glu Lys Gln Arg Lys Asp 100 105 110 Lys Val Phe Gln Gly Asn Phe Asp Asn Asp Thr His Arg Lys Asn Val 115 120 125 Ile Asp Pro Pro Ile Tyr Ala Arg His Ile Arg Ile Leu Pro Trp Ser 130 135 140 Trp Tyr Gly Arg Ile Thr Leu Arg Ser Glu Leu Leu Gly Cys 145 150 155 <210> 147 <211> 805 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido Sintético" <400> 147 Leu Asp Ile Cys Ser Lys Asn Pro Cys His Asn Gly Gly Leu Cys Glu 1 5 10 15 Glu Ile Ser Gln Glu Val Arg Gly Asp Val Phe Pro Ser Tyr Thr Cys 20 25 30 Thr Cys Leu Lys Gly Tyr Ala Gly Asn His Cys Glu Thr Lys Gly Ser 35 40 45 Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 50 55 60 Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 65 70 75 80 Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 85 90 95 Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 100 105 110 Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 115 120 125 Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 130 135 140 Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 145 150 155 160 Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 165 170 175 Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 180 185 190 Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 195 200 205 Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 210 215 220 Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 225 230 235 240 Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 245 250 255 Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 260 265 270 Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 275 280 285 Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 290 295 300 Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 305 310 315 320 Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 325 330 335 Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 340 345 350 Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 355 360 365 Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 370 375 380 Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 385 390 395 400 Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 405 410 415 Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 420 425 430 Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 435 440 445 Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 450 455 460 Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 465 470 475 480 Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 485 490 495 Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 500 505 510 Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 515 520 525 Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 530 535 540 Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 545 550 555 560 Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 565 570 575 Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 580 585 590 Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 595 600 605 Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 610 615 620 Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Ser Gly Gly Ser Gly 625 630 635 640 Gly Ser Gly Gly Ser Cys Val Glu Pro Leu Gly Met Glu Asn Gly Asn 645 650 655 Ile Ala Asn Ser Gln Ile Ala Ala Ser Ser Val Arg Val Thr Phe Leu 660 665 670 Gly Leu Gln His Trp Val Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly 675 680 685 Met Val Asn Ala Trp Thr Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile 690 695 700 Gln Val Asn Leu Leu Arg Arg Met Trp Val Thr Gly Val Val Thr Gln 705 710 715 720 Gly Ala Ser Arg Leu Ala Ser His Glu Tyr Leu Lys Ala Phe Lys Val 725 730 735 Ala Tyr Ser Leu Asn Gly His Glu Phe Asp Phe Ile His Asp Val Asn 740 745 750 Lys Lys His Lys Glu Phe Val Gly Asn Trp Asn Lys Asn Ala Val His 755 760 765 Val Asn Leu Phe Glu Thr Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr 770 775 780 Pro Thr Ser Cys His Thr Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly 785 790 795 800 Cys Glu Leu Asn Gly 805 <210> 148 <211> 2415 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido Sintético" <400> 148 ctggacatct gtagcaagaa cccttgccac aacggcggcc tgtgcgaaga gatttctcaa 60 gaagtgcggg gcgacgtttt ccccagctac acctgtacat gtctgaaggg ctacgccggc 120 aaccactgcg agacaaaagg atctgatgcc cacaagagcg aggtggccca cagattcaag 180 gatctgggcg aagagaactt caaggccctg gtgctgatcg ccttcgctca gtatctccag 240 cagagccctt tcgaggacca cgtgaagctg gtcaacgaag tgaccgagtt cgccaagacc 300 tgtgtggccg atgagagcgc cgagaactgt gataagagcc tgcacaccct gttcggcgac 360 aagctgtgta cagtggccac actgagagaa acctacggcg agatggccga ctgctgtgcc 420 aagcaagagc ccgagagaaa cgagtgcttc ctccagcaca aggacgacaa ccccaacctg 480 cctagactcg tgcgacccga agtggatgtg atgtgcaccg cctttcacga caacgaggaa 540 accttcctga agaagtacct gtacgagatc gccagacggc acccctactt ttatgcccct 600 gagctgctgt tcttcgccaa gcggtataag gccgccttca ccgaatgttg ccaggccgct 660 gataaggctg cctgtctgct gcctaagctg gacgagctga gagatgaggg caaagccagc 720 tctgccaagc agagactgaa atgcgccagc ctccagaagt tcggcgagag agcttttaag 780 gcctgggccg ttgccagact gagccagaga tttcctaagg ccgagtttgc cgaggtgtcc 840 aagctcgtga ccgatctgac aaaggtgcac accgagtgct gtcacggcga tctgctggaa 900 tgtgccgacg atagagccga cctggccaag tacatctgcg agaaccagga cagcatcagc 960 agcaagctga aagagtgctg cgagaagccc ctgctggaaa agtctcactg tatcgccgag 1020 gtggaaaacg acgagatgcc tgccgatctg cctagcctgg ctgccgattt cgtggaaagc 1080 aaggacgtgt gcaagaacta cgccgaggcc aaggatgtgt ttctgggcat gtttctgtat 1140 gagtacgccc gcagacaccc cgactattct gtggttctgc tgctgcggct ggccaaaacc 1200 tacgagacaa ccctggaaaa atgctgcgcc gctgccgatc ctcacgagtg ttatgccaag 1260 gtgttcgacg agttcaagcc tctggtggaa gaaccccaga acctgatcaa gcagaactgc 1320 gagctgttcg agcagctggg cgagtacaag ttccagaatg ccctgctcgt gcggtacacc 1380 aagaaagtgc ctcaggtgtc cacacctaca ctggttgagg tgtcccggaa tctgggcaaa 1440 gtgggcagca agtgttgcaa gcaccctgag gccaagagaa tgccttgcgc cgaggattac 1500 ctgagcgtgg tgctgaatca gctgtgcgtg ctgcacgaga aaacccctgt gtccgacaga 1560 gtgaccaagt gctgtaccga gagcctcgtg aacagaaggc cttgctttag cgccctggaa 1620 gtggacgaga catacgtgcc caaagagttc aacgccgaga cattcacctt ccacgccgac 1680 atctgcaccc tgtccgagaa agagcggcag atcaagaagc agacagccct ggtcgagctg 1740 gttaagcaca agcccaaggc caccaaagaa cagctgaagg ccgtgatgga cgacttcgcc 1800 gcctttgtcg agaagtgctg caaggccgac gacaaagaga catgcttcgc cgaagagggc 1860 aagaaactgg tggctgcctc tcaggctgct ctcggacttg gtggaagcgg aggaagtggt 1920 ggatctggcg gatcttgtgt ggaacccctc ggcatggaaa acggcaatat cgccaatagc 1980 cagattgccg ccagcagcgt cagagtgaca tttctgggac tgcaacactg ggtgcccgag 2040 ctggctagac tgaatagagc cggcatggtc aacgcctgga cacccagcag caacgacgat 2100 aatccctgga ttcaagtgaa cctgctgcgg cgtatgtggg tcacaggtgt tgttacacag 2160 ggcgcaagca gactggccag ccacgagtat ctgaaggcct ttaaggtggc ctacagcctg 2220 aacggccacg agttcgactt catccacgac gtgaacaaga agcacaaaga gtttgtcggc 2280 aactggaaca agaacgccgt gcacgtgaac ctgttcgaga cacctgtgga agcccagtac 2340 gtgcggctgt accctacaag ctgtcacacc gcctgcactc tgagattcga actgctggga 2400 tgcgagctga acggc 2415