LISTADO DE SECUENCIAS <110> GENENTECH, INC. <120> ANTICUERPOS ANTI-KLK7, ANTICUERPOS ANTI-KLK5, ANTICUERPOS MULTIESPECIFICOS ANTI-KLK5/KLK7, Y METODOS DE USO <130> 01146-0092-00PCT <150> US 62/901,990 <151> 2019-09-18 <160> 199 <170> PatentIn version 3.5 <210> 1 <211> 293 <212> PRT <213> Homo sapiens <400> 1 Met Ala Thr Ala Arg Pro Pro Trp Met Trp Val Leu Cys Ala Leu Ile 1 5 10 15 Thr Ala Leu Leu Leu Gly Val Thr Glu His Val Leu Ala Asn Asn Asp 20 25 30 Val Ser Cys Asp His Pro Ser Asn Thr Val Pro Ser Gly Ser Asn Gln 35 40 45 Asp Leu Gly Ala Gly Ala Gly Glu Asp Ala Arg Ser Asp Asp Ser Ser 50 55 60 Ser Arg Ile Ile Asn Gly Ser Asp Cys Asp Met His Thr Gln Pro Trp 65 70 75 80 Gln Ala Ala Leu Leu Leu Arg Pro Asn Gln Leu Tyr Cys Gly Ala Val 85 90 95 Leu Val His Pro Gln Trp Leu Leu Thr Ala Ala His Cys Arg Lys Lys 100 105 110 Val Phe Arg Val Arg Leu Gly His Tyr Ser Leu Ser Pro Val Tyr Glu 115 120 125 Ser Gly Gln Gln Met Phe Gln Gly Val Lys Ser Ile Pro His Pro Gly 130 135 140 Tyr Ser His Pro Gly His Ser Asn Asp Leu Met Leu Ile Lys Leu Asn 145 150 155 160 Arg Arg Ile Arg Pro Thr Lys Asp Val Arg Pro Ile Asn Val Ser Ser 165 170 175 His Cys Pro Ser Ala Gly Thr Lys Cys Leu Val Ser Gly Trp Gly Thr 180 185 190 Thr Lys Ser Pro Gln Val His Phe Pro Lys Val Leu Gln Cys Leu Asn 195 200 205 Ile Ser Val Leu Ser Gln Lys Arg Cys Glu Asp Ala Tyr Pro Arg Gln 210 215 220 Ile Asp Asp Thr Met Phe Cys Ala Gly Asp Lys Ala Gly Arg Asp Ser 225 230 235 240 Cys Gln Gly Asp Ser Gly Gly Pro Val Val Cys Asn Gly Ser Leu Gln 245 250 255 Gly Leu Val Ser Trp Gly Asp Tyr Pro Cys Ala Arg Pro Asn Arg Pro 260 265 270 Gly Val Tyr Thr Asn Leu Cys Lys Phe Thr Lys Trp Ile Gln Glu Thr 275 280 285 Ile Gln Ala Asn Ser 290 <210> 2 <211> 227 <212> PRT <213> Homo sapiens <400> 2 Ile Ile Asn Gly Ser Asp Cys Asp Met His Thr Gln Pro Trp Gln Ala 1 5 10 15 Ala Leu Leu Leu Arg Pro Asn Gln Leu Tyr Cys Gly Ala Val Leu Val 20 25 30 His Pro Gln Trp Leu Leu Thr Ala Ala His Cys Arg Lys Lys Val Phe 35 40 45 Arg Val Arg Leu Gly His Tyr Ser Leu Ser Pro Val Tyr Glu Ser Gly 50 55 60 Gln Gln Met Phe Gln Gly Val Lys Ser Ile Pro His Pro Gly Tyr Ser 65 70 75 80 His Pro Gly His Ser Asn Asp Leu Met Leu Ile Lys Leu Asn Arg Arg 85 90 95 Ile Arg Pro Thr Lys Asp Val Arg Pro Ile Asn Val Ser Ser His Cys 100 105 110 Pro Ser Ala Gly Thr Lys Cys Leu Val Ser Gly Trp Gly Thr Thr Lys 115 120 125 Ser Pro Gln Val His Phe Pro Lys Val Leu Gln Cys Leu Asn Ile Ser 130 135 140 Val Leu Ser Gln Lys Arg Cys Glu Asp Ala Tyr Pro Arg Gln Ile Asp 145 150 155 160 Asp Thr Met Phe Cys Ala Gly Asp Lys Ala Gly Arg Asp Ser Cys Gln 165 170 175 Gly Asp Ser Gly Gly Pro Val Val Cys Asn Gly Ser Leu Gln Gly Leu 180 185 190 Val Ser Trp Gly Asp Tyr Pro Cys Ala Arg Pro Asn Arg Pro Gly Val 195 200 205 Tyr Thr Asn Leu Cys Lys Phe Thr Lys Trp Ile Gln Glu Thr Ile Gln 210 215 220 Ala Asn Ser 225 <210> 3 <211> 253 <212> PRT <213> Homo sapiens <400> 3 Met Ala Arg Ser Leu Leu Leu Pro Leu Gln Ile Leu Leu Leu Ser Leu 1 5 10 15 Ala Leu Glu Thr Ala Gly Glu Glu Ala Gln Gly Asp Lys Ile Ile Asp 20 25 30 Gly Ala Pro Cys Ala Arg Gly Ser His Pro Trp Gln Val Ala Leu Leu 35 40 45 Ser Gly Asn Gln Leu His Cys Gly Gly Val Leu Val Asn Glu Arg Trp 50 55 60 Val Leu Thr Ala Ala His Cys Lys Met Asn Glu Tyr Thr Val His Leu 65 70 75 80 Gly Ser Asp Thr Leu Gly Asp Arg Arg Ala Gln Arg Ile Lys Ala Ser 85 90 95 Lys Ser Phe Arg His Pro Gly Tyr Ser Thr Gln Thr His Val Asn Asp 100 105 110 Leu Met Leu Val Lys Leu Asn Ser Gln Ala Arg Leu Ser Ser Met Val 115 120 125 Lys Lys Val Arg Leu Pro Ser Arg Cys Glu Pro Pro Gly Thr Thr Cys 130 135 140 Thr Val Ser Gly Trp Gly Thr Thr Thr Ser Pro Asp Val Thr Phe Pro 145 150 155 160 Ser Asp Leu Met Cys Val Asp Val Lys Leu Ile Ser Pro Gln Asp Cys 165 170 175 Thr Lys Val Tyr Lys Asp Leu Leu Glu Asn Ser Met Leu Cys Ala Gly 180 185 190 Ile Pro Asp Ser Lys Lys Asn Ala Cys Asn Gly Asp Ser Gly Gly Pro 195 200 205 Leu Val Cys Arg Gly Thr Leu Gln Gly Leu Val Ser Trp Gly Thr Phe 210 215 220 Pro Cys Gly Gln Pro Asn Asp Pro Gly Val Tyr Thr Gln Val Cys Lys 225 230 235 240 Phe Thr Lys Trp Ile Asn Asp Thr Met Lys Lys His Arg 245 250 <210> 4 <211> 224 <212> PRT <213> Homo sapiens <400> 4 Ile Ile Asp Gly Ala Pro Cys Ala Arg Gly Ser His Pro Trp Gln Val 1 5 10 15 Ala Leu Leu Ser Gly Asn Gln Leu His Cys Gly Gly Val Leu Val Asn 20 25 30 Glu Arg Trp Val Leu Thr Ala Ala His Cys Lys Met Asn Glu Tyr Thr 35 40 45 Val His Leu Gly Ser Asp Thr Leu Gly Asp Arg Arg Ala Gln Arg Ile 50 55 60 Lys Ala Ser Lys Ser Phe Arg His Pro Gly Tyr Ser Thr Gln Thr His 65 70 75 80 Val Asn Asp Leu Met Leu Val Lys Leu Asn Ser Gln Ala Arg Leu Ser 85 90 95 Ser Met Val Lys Lys Val Arg Leu Pro Ser Arg Cys Glu Pro Pro Gly 100 105 110 Thr Thr Cys Thr Val Ser Gly Trp Gly Thr Thr Thr Ser Pro Asp Val 115 120 125 Thr Phe Pro Ser Asp Leu Met Cys Val Asp Val Lys Leu Ile Ser Pro 130 135 140 Gln Asp Cys Thr Lys Val Tyr Lys Asp Leu Leu Glu Asn Ser Met Leu 145 150 155 160 Cys Ala Gly Ile Pro Asp Ser Lys Lys Asn Ala Cys Asn Gly Asp Ser 165 170 175 Gly Gly Pro Leu Val Cys Arg Gly Thr Leu Gln Gly Leu Val Ser Trp 180 185 190 Gly Thr Phe Pro Cys Gly Gln Pro Asn Asp Pro Gly Val Tyr Thr Gln 195 200 205 Val Cys Lys Phe Thr Lys Trp Ile Asn Asp Thr Met Lys Lys His Arg 210 215 220 <210> 5 <211> 253 <212> PRT <213> Macaca fascicularis <400> 5 Met Ala Gly Ser Leu Leu Leu Pro Leu Gln Ile Leu Leu Leu Ser Leu 1 5 10 15 Ala Leu Gly Thr Ala Gly Gln Glu Ala Gln Gly Asp Lys Ile Ile Asp 20 25 30 Gly Ala Pro Cys Thr Arg Gly Ser His Pro Trp Gln Val Ala Leu Leu 35 40 45 Ser Gly Asn Gln Leu His Cys Gly Gly Val Leu Val Asn Glu Arg Trp 50 55 60 Val Leu Thr Ala Ala His Cys Lys Met Asn Asp Tyr Thr Val His Leu 65 70 75 80 Gly Ser Asp Thr Leu Gly Asp Arg Lys Ala Gln Arg Ile Lys Ala Ser 85 90 95 Arg Ser Phe Arg His Pro Gly Tyr Ser Thr Gln Thr His Val Asn Asp 100 105 110 Leu Met Leu Val Lys Leu Asn Ser Pro Ala Arg Leu Ser Ser Thr Val 115 120 125 Lys Lys Val Arg Leu Pro Ser Arg Cys Glu Pro Pro Gly Thr Thr Cys 130 135 140 Thr Val Ser Gly Trp Gly Thr Thr Thr Ser Pro Asp Val Thr Phe Pro 145 150 155 160 Ser Asp Leu Met Cys Val Asp Val Lys Leu Ile Ser Ser Gln Asp Cys 165 170 175 Thr Lys Val Tyr Lys Asp Met Leu Gly Asn Ser Met Leu Cys Ala Gly 180 185 190 Ile Pro Asn Ser Lys Lys Asn Ala Cys Asn Gly Asp Ser Gly Gly Pro 195 200 205 Leu Val Cys Arg Gly Thr Leu Gln Gly Leu Val Ser Trp Gly Thr Phe 210 215 220 Pro Cys Gly Gln Pro Asn Asp Pro Gly Val Tyr Thr Gln Val Cys Lys 225 230 235 240 Phe Thr Lys Trp Ile Asn Asp Thr Ile Lys Lys His Arg 245 250 <210> 6 <211> 224 <212> PRT <213> Macaca fascicularis <400> 6 Ile Ile Asp Gly Ala Pro Cys Thr Arg Gly Ser His Pro Trp Gln Val 1 5 10 15 Ala Leu Leu Ser Gly Asn Gln Leu His Cys Gly Gly Val Leu Val Asn 20 25 30 Glu Arg Trp Val Leu Thr Ala Ala His Cys Lys Met Asn Asp Tyr Thr 35 40 45 Val His Leu Gly Ser Asp Thr Leu Gly Asp Arg Lys Ala Gln Arg Ile 50 55 60 Lys Ala Ser Arg Ser Phe Arg His Pro Gly Tyr Ser Thr Gln Thr His 65 70 75 80 Val Asn Asp Leu Met Leu Val Lys Leu Asn Ser Pro Ala Arg Leu Ser 85 90 95 Ser Thr Val Lys Lys Val Arg Leu Pro Ser Arg Cys Glu Pro Pro Gly 100 105 110 Thr Thr Cys Thr Val Ser Gly Trp Gly Thr Thr Thr Ser Pro Asp Val 115 120 125 Thr Phe Pro Ser Asp Leu Met Cys Val Asp Val Lys Leu Ile Ser Ser 130 135 140 Gln Asp Cys Thr Lys Val Tyr Lys Asp Met Leu Gly Asn Ser Met Leu 145 150 155 160 Cys Ala Gly Ile Pro Asn Ser Lys Lys Asn Ala Cys Asn Gly Asp Ser 165 170 175 Gly Gly Pro Leu Val Cys Arg Gly Thr Leu Gln Gly Leu Val Ser Trp 180 185 190 Gly Thr Phe Pro Cys Gly Gln Pro Asn Asp Pro Gly Val Tyr Thr Gln 195 200 205 Val Cys Lys Phe Thr Lys Trp Ile Asn Asp Thr Ile Lys Lys His Arg 210 215 220 <210> 7 <211> 6 <212> PRT <213> Secuencia artificial <220> <223> 14H11c CDRH1 <400> 7 Ser Ser Tyr Tyr Met Ser 1 5 <210> 8 <211> 18 <212> PRT <213> Secuencia artificial <220> <223> 14H11c CDRH2 <400> 8 Ser Ile Tyr Ala Gly Ser Ser Gly Ala Pro Tyr Tyr Ala Gly Trp Ala 1 5 10 15 Lys Gly <210> 9 <211> 17 <212> PRT <213> Secuencia artificial <220> <223> 14H11c CDRH2 <400> 9 Glu Gly Phe Ala Glu Thr Gly Gly Tyr Gly Tyr Ala Ala Tyr Phe Asn 1 5 10 15 Leu <210> 10 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> 14H11c CDRL1 <400> 10 Leu Ala Ser Glu Asp Ile Ala Ser Ser Val Ser 1 5 10 <210> 11 <211> 7 <212> PRT <213> Secuencia artificial <220> <223> 14H11c CDRL2 <400> 11 Gly Ala Ser Asn Leu Glu Ser 1 5 <210> 12 <211> 12 <212> PRT <213> Secuencia artificial <220> <223> 14H11c CDRL3 <400> 12 Leu Gly Gly Tyr Ser Tyr Ser Ser Thr Gly Thr Ala 1 5 10 <210> 13 <211> 126 <212> PRT <213> Secuencia artificial <220> <223> región variable de la cadena pesada (VH) rb.14H11c <400> 13 Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Ser Tyr 20 25 30 Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Ala Ser Ile Tyr Ala Gly Ser Ser Gly Ala Pro Tyr Tyr Ala Gly Trp 50 55 60 Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Ala Val Thr 65 70 75 80 Leu Gln Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 85 90 95 Ala Arg Glu Gly Phe Ala Glu Thr Gly Gly Tyr Gly Tyr Ala Ala Tyr 100 105 110 Phe Asn Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 14 <211> 110 <212> PRT <213> Secuencia artificial <220> <223> región variable de la cadena liviana (VL) rb.14H11c; rb.14H11 VL <400> 14 Ala Ile Glu Met Thr Gln Ser Pro Pro Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Glu Thr Val Arg Ile Arg Cys Leu Ala Ser Glu Asp Ile Ala Ser Ser 20 25 30 Val Ser Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Thr Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Asn Leu Glu Ser Gly Val Pro Pro Arg Phe Thr Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Gly Gly Val Gln Ala 65 70 75 80 Glu Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Ser Tyr Ser Ser 85 90 95 Thr Gly Thr Ala Phe Gly Ala Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 15 <211> 128 <212> PRT <213> Secuencia artificial <220> <223> hu.14H11c.V3-53*1.H1 VH <400> 15 Glu Gln Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Ser 20 25 30 Tyr Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Ala Ser Ile Tyr Ala Gly Ser Ser Gly Ala Pro Tyr Tyr Ala Gly 50 55 60 Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr 65 70 75 80 Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 85 90 95 Phe Cys Ala Arg Glu Gly Phe Ala Glu Thr Gly Gly Tyr Gly Tyr Ala 100 105 110 Ala Tyr Phe Asn Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 16 <211> 128 <212> PRT <213> Secuencia artificial <220> <223> hu.14H11c.V3-53*1.H2 VH <400> 16 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Ser 20 25 30 Tyr Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Ala Ser Ile Tyr Ala Gly Ser Ser Gly Ala Pro Tyr Tyr Ala Gly 50 55 60 Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr 65 70 75 80 Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 85 90 95 Phe Cys Ala Arg Glu Gly Phe Ala Glu Thr Gly Gly Tyr Gly Tyr Ala 100 105 110 Ala Tyr Phe Asn Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 17 <211> 128 <212> PRT <213> Secuencia artificial <220> <223> hu.14H11c.V3-53*1.H3 VH <400> 17 Glu Gln Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Ser 20 25 30 Tyr Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 35 40 45 Val Ala Ser Ile Tyr Ala Gly Ser Ser Gly Ala Pro Tyr Tyr Ala Gly 50 55 60 Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr 65 70 75 80 Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 85 90 95 Phe Cys Ala Arg Glu Gly Phe Ala Glu Thr Gly Gly Tyr Gly Tyr Ala 100 105 110 Ala Tyr Phe Asn Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 18 <211> 128 <212> PRT <213> Secuencia artificial <220> <223> hu.14H11c.V3-53*1.H4 VH <400> 18 Glu Gln Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Ser 20 25 30 Tyr Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Ser Ser Ile Tyr Ala Gly Ser Ser Gly Ala Pro Tyr Tyr Ala Gly 50 55 60 Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr 65 70 75 80 Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 85 90 95 Phe Cys Ala Arg Glu Gly Phe Ala Glu Thr Gly Gly Tyr Gly Tyr Ala 100 105 110 Ala Tyr Phe Asn Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 19 <211> 128 <212> PRT <213> Secuencia artificial <220> <223> hu.14H11c.V3-53*1.H5 VH <400> 19 Glu Gln Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Ser 20 25 30 Tyr Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Ala Ser Ile Tyr Ala Gly Ser Ser Gly Ala Pro Tyr Tyr Ala Gly 50 55 60 Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Lys Asn Thr 65 70 75 80 Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 85 90 95 Phe Cys Ala Arg Glu Gly Phe Ala Glu Thr Gly Gly Tyr Gly Tyr Ala 100 105 110 Ala Tyr Phe Asn Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 20 <211> 128 <212> PRT <213> Secuencia artificial <220> <223> hu.14H11c.V3-53*1.H6 VH <400> 20 Glu Gln Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Ser 20 25 30 Tyr Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Ala Ser Ile Tyr Ala Gly Ser Ser Gly Ala Pro Tyr Tyr Ala Gly 50 55 60 Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr 65 70 75 80 Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 85 90 95 Phe Cys Ala Arg Glu Gly Phe Ala Glu Thr Gly Gly Tyr Gly Tyr Ala 100 105 110 Ala Tyr Phe Asn Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 21 <211> 128 <212> PRT <213> Secuencia artificial <220> <223> hu.14H11c.V3-53*1.H7 VH <400> 21 Glu Gln Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Ser 20 25 30 Tyr Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Ala Ser Ile Tyr Ala Gly Ser Ser Gly Ala Pro Tyr Tyr Ala Gly 50 55 60 Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 85 90 95 Phe Cys Ala Arg Glu Gly Phe Ala Glu Thr Gly Gly Tyr Gly Tyr Ala 100 105 110 Ala Tyr Phe Asn Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 22 <211> 128 <212> PRT <213> Secuencia artificial <220> <223> hu.14H11c.V3-53*1.H8 VH <400> 22 Glu Gln Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Ser 20 25 30 Tyr Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Ala Ser Ile Tyr Ala Gly Ser Ser Gly Ala Pro Tyr Tyr Ala Gly 50 55 60 Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr 65 70 75 80 Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Ala Arg Glu Gly Phe Ala Glu Thr Gly Gly Tyr Gly Tyr Ala 100 105 110 Ala Tyr Phe Asn Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 23 <211> 128 <212> PRT <213> Secuencia artificial <220> <223> hu.14H11c.V3-53*1.H9 VH <400> 23 Glu Gln Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Ser 20 25 30 Tyr Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Ala Ser Ile Tyr Ala Gly Ser Ser Gly Ala Pro Tyr Tyr Ala Gly 50 55 60 Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr 65 70 75 80 Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 85 90 95 Phe Cys Ala Arg Glu Gly Phe Ala Glu Thr Gly Gly Tyr Gly Tyr Ala 100 105 110 Ala Tyr Phe Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 24 <211> 128 <212> PRT <213> Secuencia artificial <220> <223> hu.14H11c.V3-53*1.H10 VH <400> 24 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Ser 20 25 30 Tyr Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 35 40 45 Val Ser Ser Ile Tyr Ala Gly Ser Ser Gly Ala Pro Tyr Tyr Ala Gly 50 55 60 Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Ala Arg Glu Gly Phe Ala Glu Thr Gly Gly Tyr Gly Tyr Ala 100 105 110 Ala Tyr Phe Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 25 <211> 128 <212> PRT <213> Secuencia artificial <220> <223> hu.14H11c.V3-53*4.H1 VH <400> 25 Glu Gln Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Ser 20 25 30 Tyr Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Ala Ser Ile Tyr Ala Gly Ser Ser Gly Ala Pro Tyr Tyr Ala Gly 50 55 60 Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys His Ser Ser Lys Asn Thr 65 70 75 80 Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 85 90 95 Phe Cys Ala Arg Glu Gly Phe Ala Glu Thr Gly Gly Tyr Gly Tyr Ala 100 105 110 Ala Tyr Phe Asn Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 26 <211> 128 <212> PRT <213> Secuencia artificial <220> <223> hu.14H11c.V3-23.H1 VH <400> 26 Glu Gln Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Ser 20 25 30 Tyr Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Ala Ser Ile Tyr Ala Gly Ser Ser Gly Ala Pro Tyr Tyr Ala Gly 50 55 60 Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr 65 70 75 80 Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 85 90 95 Phe Cys Ala Arg Glu Gly Phe Ala Glu Thr Gly Gly Tyr Gly Tyr Ala 100 105 110 Ala Tyr Phe Asn Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 27 <211> 128 <212> PRT <213> Secuencia artificial <220> <223> hu.14H11c.V3-33*2.H1 VH <400> 27 Glu Gln Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Ser 20 25 30 Tyr Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Ala Ser Ile Tyr Ala Gly Ser Ser Gly Ala Pro Tyr Tyr Ala Gly 50 55 60 Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Thr Asn Thr 65 70 75 80 Val Phe Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 85 90 95 Phe Cys Ala Arg Glu Gly Phe Ala Glu Thr Gly Gly Tyr Gly Tyr Ala 100 105 110 Ala Tyr Phe Asn Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 28 <211> 128 <212> PRT <213> Secuencia artificial <220> <223> hu.14H11c.V3-21.H1 VH <400> 28 Glu Gln Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Ser 20 25 30 Tyr Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Ala Ser Ile Tyr Ala Gly Ser Ser Gly Ala Pro Tyr Tyr Ala Gly 50 55 60 Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Thr Ala Ser Thr Ser 65 70 75 80 Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 85 90 95 Phe Cys Ala Arg Glu Gly Phe Ala Glu Thr Gly Gly Tyr Gly Tyr Ala 100 105 110 Ala Tyr Phe Asn Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 29 <211> 128 <212> PRT <213> Secuencia artificial <220> <223> hu.14H11c-H11 VH <400> 29 Glu Gln Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Ser 20 25 30 Tyr Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 35 40 45 Val Ser Ser Ile Tyr Ala Gly Ser Ser Gly Ala Pro Tyr Tyr Ala Gly 50 55 60 Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Ala Arg Glu Gly Phe Ala Glu Thr Gly Gly Tyr Gly Tyr Ala 100 105 110 Ala Tyr Phe Asn Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 30 <211> 128 <212> PRT <213> Secuencia artificial <220> <223> hu.14H11c-H11.Q39E VH <400> 30 Glu Gln Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Ser 20 25 30 Tyr Tyr Met Ser Trp Val Arg Glu Ala Pro Gly Lys Gly Leu Glu Trp 35 40 45 Val Ser Ser Ile Tyr Ala Gly Ser Ser Gly Ala Pro Tyr Tyr Ala Gly 50 55 60 Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Ala Arg Glu Gly Phe Ala Glu Thr Gly Gly Tyr Gly Tyr Ala 100 105 110 Ala Tyr Phe Asn Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 31 <211> 110 <212> PRT <213> Secuencia artificial <220> <223> hu.14H11c.K1-39.L1 VL <400> 31 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Leu Ala Ser Glu Asp Ile Ala Ser Ser 20 25 30 Val Ser Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Ser Tyr Ser Ser 85 90 95 Thr Gly Thr Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 32 <211> 110 <212> PRT <213> Secuencia artificial <220> <223> hu.14H11c.K1-39.L2 VL <400> 32 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Leu Ala Ser Glu Asp Ile Ala Ser Ser 20 25 30 Val Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Ser Tyr Ser Ser 85 90 95 Thr Gly Thr Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 33 <211> 110 <212> PRT <213> Secuencia artificial <220> <223> hu.14H11c.K1-39.L3 VL <400> 33 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Leu Ala Ser Glu Asp Ile Ala Ser Ser 20 25 30 Val Ser Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Ser Tyr Ser Ser 85 90 95 Thr Gly Thr Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 34 <211> 110 <212> PRT <213> Secuencia artificial <220> <223> hu.14H11c.K1-39.L4 VL <400> 34 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Leu Ala Ser Glu Asp Ile Ala Ser Ser 20 25 30 Val Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Ser Tyr Ser Ser 85 90 95 Thr Gly Thr Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 35 <211> 110 <212> PRT <213> Secuencia artificial <220> <223> hu.14H11c.K1-5.L1 VL <400> 35 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Leu Ala Ser Glu Asp Ile Ala Ser Ser 20 25 30 Val Ser Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Ser Tyr Ser Ser 85 90 95 Thr Gly Thr Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 36 <211> 110 <212> PRT <213> Secuencia artificial <220> <223> hu.14H11c.K1-8.L1 VL <400> 36 Ala Ile Arg Met Thr Gln Ser Pro Ser Ser Phe Ser Ala Ser Thr Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Leu Ala Ser Glu Asp Ile Ala Ser Ser 20 25 30 Val Ser Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Ser Tyr Ser Ser 85 90 95 Thr Gly Thr Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 37 <211> 110 <212> PRT <213> Secuencia artificial <220> <223> hu.14H11c.K1-6.L1 VL <400> 37 Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Leu Ala Ser Glu Asp Ile Ala Ser Ser 20 25 30 Val Ser Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Ser Tyr Ser Ser 85 90 95 Thr Gly Thr Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 38 <211> 110 <212> PRT <213> Secuencia artificial <220> <223> hu.14H11c-L2.Q38K VL <400> 38 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Leu Ala Ser Glu Asp Ile Ala Ser Ser 20 25 30 Val Ser Trp Tyr Gln Lys Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Ser Tyr Ser Ser 85 90 95 Thr Gly Thr Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 39 <211> 5 <212> PRT <213> Secuencia artificial <220> <223> CDRH1 <400> 39 Ser Tyr Gly Val Thr 1 5 <210> 40 <211> 17 <212> PRT <213> Secuencia artificial <220> <223> CDRH2 <400> 40 Tyr Ile Thr Ser Asn Tyr Gly Val Ser Tyr Tyr Ala Ser Trp Ala Lys 1 5 10 15 Ser <210> 41 <211> 17 <212> PRT <213> Secuencia artificial <220> <223> CDRH2 <400> 41 Tyr Ile Thr Ser Val Tyr Gly Val Ser Tyr Tyr Ala Ser Trp Ala Lys 1 5 10 15 Ser <210> 42 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> CDRH3 <400> 42 Glu Asn Pro Asp Tyr Gly Tyr Ala Tyr Asp Ala 1 5 10 <210> 43 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> CDRL1 <400> 43 Gln Ala Ser Glu Ser Ile Ser Asn Glu Leu Ser 1 5 10 <210> 44 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> CDRL1 <400> 44 Gln Ala Ser Glu Ser Ile Ser Asn Glu Leu Lys 1 5 10 <210> 45 <211> 7 <212> PRT <213> Secuencia artificial <220> <223> CDRL2 <400> 45 Tyr Ala Ser Thr Leu Ala Ser 1 5 <210> 46 <211> 12 <212> PRT <213> Secuencia artificial <220> <223> CDRL3 <400> 46 Ala Gln Gly Phe Gly Ser Ser Gly Val Glu Asn Val 1 5 10 <210> 47 <211> 12 <212> PRT <213> Secuencia artificial <220> <223> CDRL3 <400> 47 Ala Gln Gly Tyr Gly Ser Ser Gly Val Glu Asn Val 1 5 10 <210> 48 <211> 12 <212> PRT <213> Secuencia artificial <220> <223> CDRL3 <400> 48 Ala Gln Gly Phe Gly Ser Phe Gly Val Glu Asn Val 1 5 10 <210> 49 <211> 12 <212> PRT <213> Secuencia artificial <220> <223> CDRL3 <400> 49 Ala Gln Gly Tyr Gly Ser Phe Gly Val Glu Asn Val 1 5 10 <210> 50 <211> 120 <212> PRT <213> Secuencia artificial <220> <223> hu.10C5-H28L5 VH <400> 50 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 20 25 30 Gly Val Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Thr Ser Asn Tyr Gly Val Ser Tyr Tyr Ala Ser Trp Ala 50 55 60 Lys Ser Arg Ser Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Val Tyr 65 70 75 80 Leu Gln Met Gly Ser Leu Arg Ala Glu Asp Met Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Asn Pro Asp Tyr Gly Tyr Ala Tyr Asp Ala Trp Gly Gln 100 105 110 Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 51 <211> 110 <212> PRT <213> Secuencia artificial <220> <223> hu.10C5-H28L5 VL <400> 51 Ala Ile Arg Met Thr Gln Ser Pro Ser Ser Phe Ser Ala Ser Thr Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Ser Asn Glu 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Tyr Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Gly Phe Gly Ser Ser Gly 85 90 95 Val Glu Asn Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 52 <211> 120 <212> PRT <213> Secuencia artificial <220> <223> hu.10C5-H28.N53V VH <400> 52 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 20 25 30 Gly Val Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Thr Ser Val Tyr Gly Val Ser Tyr Tyr Ala Ser Trp Ala 50 55 60 Lys Ser Arg Ser Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Val Tyr 65 70 75 80 Leu Gln Met Gly Ser Leu Arg Ala Glu Asp Met Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Asn Pro Asp Tyr Gly Tyr Ala Tyr Asp Ala Trp Gly Gln 100 105 110 Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 53 <211> 120 <212> PRT <213> Secuencia artificial <220> <223> hu.10C5-H28.Q39K.N53V VH <400> 53 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 20 25 30 Gly Val Thr Trp Val Arg Lys Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Thr Ser Val Tyr Gly Val Ser Tyr Tyr Ala Ser Trp Ala 50 55 60 Lys Ser Arg Ser Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Val Tyr 65 70 75 80 Leu Gln Met Gly Ser Leu Arg Ala Glu Asp Met Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Asn Pro Asp Tyr Gly Tyr Ala Tyr Asp Ala Trp Gly Gln 100 105 110 Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 54 <211> 110 <212> PRT <213> Secuencia artificial <220> <223> hu.10C5-L5.S34K VL <400> 54 Ala Ile Arg Met Thr Gln Ser Pro Ser Ser Phe Ser Ala Ser Thr Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Ser Asn Glu 20 25 30 Leu Lys Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Tyr Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Gly Phe Gly Ser Ser Gly 85 90 95 Val Glu Asn Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 55 <211> 110 <212> PRT <213> Secuencia artificial <220> <223> hu.10C5-L5.F92Y VL <400> 55 Ala Ile Arg Met Thr Gln Ser Pro Ser Ser Phe Ser Ala Ser Thr Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Ser Asn Glu 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Tyr Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Gly Tyr Gly Ser Ser Gly 85 90 95 Val Glu Asn Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 56 <211> 110 <212> PRT <213> Secuencia artificial <220> <223> hu.10C5-L5.S95F VL <400> 56 Ala Ile Arg Met Thr Gln Ser Pro Ser Ser Phe Ser Ala Ser Thr Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Ser Asn Glu 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Tyr Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Gly Phe Gly Ser Phe Gly 85 90 95 Val Glu Asn Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 57 <211> 110 <212> PRT <213> Secuencia artificial <220> <223> hu.10C5-L5.S34K.F92Y VL <400> 57 Ala Ile Arg Met Thr Gln Ser Pro Ser Ser Phe Ser Ala Ser Thr Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Ser Asn Glu 20 25 30 Leu Lys Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Tyr Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Gly Tyr Gly Ser Ser Gly 85 90 95 Val Glu Asn Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 58 <211> 110 <212> PRT <213> Secuencia artificial <220> <223> hu.10C5-L5.S34K.S95F VL <400> 58 Ala Ile Arg Met Thr Gln Ser Pro Ser Ser Phe Ser Ala Ser Thr Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Ser Asn Glu 20 25 30 Leu Lys Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Tyr Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Gly Phe Gly Ser Phe Gly 85 90 95 Val Glu Asn Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 59 <211> 110 <212> PRT <213> Secuencia artificial <220> <223> hu.10C5-L5.F92Y.S95F VL <400> 59 Ala Ile Arg Met Thr Gln Ser Pro Ser Ser Phe Ser Ala Ser Thr Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Ser Asn Glu 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Tyr Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Gly Tyr Gly Ser Phe Gly 85 90 95 Val Glu Asn Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 60 <211> 110 <212> PRT <213> Secuencia artificial <220> <223> hu.10C5-L5.S34K.F92Y.S95F VL <400> 60 Ala Ile Arg Met Thr Gln Ser Pro Ser Ser Phe Ser Ala Ser Thr Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Ser Asn Glu 20 25 30 Leu Lys Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Tyr Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Gly Tyr Gly Ser Phe Gly 85 90 95 Val Glu Asn Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 61 <211> 110 <212> PRT <213> Secuencia artificial <220> <223> hu.10C5-L5.Q38E.S34K VL <400> 61 Ala Ile Arg Met Thr Gln Ser Pro Ser Ser Phe Ser Ala Ser Thr Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Ser Asn Glu 20 25 30 Leu Lys Trp Tyr Gln Glu Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Tyr Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Gly Phe Gly Ser Ser Gly 85 90 95 Val Glu Asn Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 62 <211> 110 <212> PRT <213> Secuencia artificial <220> <223> hu.10C5-L5.Q38E.F92Y VL <400> 62 Ala Ile Arg Met Thr Gln Ser Pro Ser Ser Phe Ser Ala Ser Thr Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Ser Asn Glu 20 25 30 Leu Ser Trp Tyr Gln Glu Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Tyr Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Gly Tyr Gly Ser Ser Gly 85 90 95 Val Glu Asn Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 63 <211> 110 <212> PRT <213> Secuencia artificial <220> <223> hu.10C5-L5.Q38E.S95F VL <400> 63 Ala Ile Arg Met Thr Gln Ser Pro Ser Ser Phe Ser Ala Ser Thr Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Ser Asn Glu 20 25 30 Leu Ser Trp Tyr Gln Glu Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Tyr Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Gly Phe Gly Ser Phe Gly 85 90 95 Val Glu Asn Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 64 <211> 110 <212> PRT <213> Secuencia artificial <220> <223> hu.10C5-L5.Q38E.S34K.F92Y VL <400> 64 Ala Ile Arg Met Thr Gln Ser Pro Ser Ser Phe Ser Ala Ser Thr Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Ser Asn Glu 20 25 30 Leu Lys Trp Tyr Gln Glu Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Tyr Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Gly Tyr Gly Ser Ser Gly 85 90 95 Val Glu Asn Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 65 <211> 110 <212> PRT <213> Secuencia artificial <220> <223> hu.10C5-L5.Q38E.S34K.S95F VL <400> 65 Ala Ile Arg Met Thr Gln Ser Pro Ser Ser Phe Ser Ala Ser Thr Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Ser Asn Glu 20 25 30 Leu Lys Trp Tyr Gln Glu Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Tyr Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Gly Phe Gly Ser Phe Gly 85 90 95 Val Glu Asn Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 66 <211> 110 <212> PRT <213> Secuencia artificial <220> <223> hu.10C5-L5.Q38E.F92Y.S95F VL <400> 66 Ala Ile Arg Met Thr Gln Ser Pro Ser Ser Phe Ser Ala Ser Thr Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Ser Asn Glu 20 25 30 Leu Ser Trp Tyr Gln Glu Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Tyr Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Gly Tyr Gly Ser Phe Gly 85 90 95 Val Glu Asn Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 67 <211> 110 <212> PRT <213> Secuencia artificial <220> <223> hu.10C5-L5.Q38E.S34K.F92Y.S95F VL <400> 67 Ala Ile Arg Met Thr Gln Ser Pro Ser Ser Phe Ser Ala Ser Thr Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Ser Asn Glu 20 25 30 Leu Lys Trp Tyr Gln Glu Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Tyr Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Gly Tyr Gly Ser Phe Gly 85 90 95 Val Glu Asn Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 68 <211> 5 <212> PRT <213> Secuencia artificial <220> <223> CDRH1 <400> 68 Ser Tyr Gly Val Ser 1 5 <210> 69 <211> 16 <212> PRT <213> Secuencia artificial <220> <223> CDRH2 <400> 69 Phe Ile Gly Ser Gly Gly Phe Ala Tyr Tyr Ala Ser Trp Ala Lys Ser 1 5 10 15 <210> 70 <211> 16 <212> PRT <213> Secuencia artificial <220> <223> CDRH2 <400> 70 Phe Ile Gly Ser Ala Gly Phe Ala Tyr Tyr Ala Ser Trp Ala Lys Ser 1 5 10 15 <210> 71 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> CDRH3 <400> 71 Asp Asp Val Gly Gly Gly Lys Ser Leu Asp Ile 1 5 10 <210> 72 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> CDRH3 <400> 72 Asp Asp Val Gln Gly Gly Lys Ser Leu Asp Ile 1 5 10 <210> 73 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> CDRL1 <400> 73 Gln Ala Ser Gln Ser Ile Ser Ser Tyr Leu Ser 1 5 10 <210> 74 <211> 7 <212> PRT <213> Secuencia artificial <220> <223> CDRL2 <400> 74 Ser Ala Ser Thr Leu Ala Ser 1 5 <210> 75 <211> 12 <212> PRT <213> Secuencia artificial <220> <223> CDRL3 <400> 75 His Gln Asp Tyr Thr Ser Ser Asn Val Asp Asn Thr 1 5 10 <210> 76 <211> 12 <212> PRT <213> Secuencia artificial <220> <223> CDRL3 <400> 76 Val Gln Asp Tyr Thr Ser Ser Asn Val Asp Asn Thr 1 5 10 <210> 77 <211> 12 <212> PRT <213> Secuencia artificial <220> <223> CDRL3 <400> 77 His Gln Asp Tyr Thr Ser Tyr Asn Val Asp Asn Thr 1 5 10 <210> 78 <211> 12 <212> PRT <213> Secuencia artificial <220> <223> CDRL3 <400> 78 Val Gln Asp Tyr Thr Ser Tyr Asn Val Asp Asn Thr 1 5 10 <210> 79 <211> 119 <212> PRT <213> Secuencia artificial <220> <223> hu.9H5-H14L4 VH <400> 79 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 20 25 30 Gly Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 35 40 45 Gly Phe Ile Gly Ser Gly Gly Phe Ala Tyr Tyr Ala Ser Trp Ala Lys 50 55 60 Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Asp Val Gly Gly Gly Lys Ser Leu Asp Ile Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 80 <211> 110 <212> PRT <213> Secuencia artificial <220> <223> hu.9H5-H14L4 VL <400> 80 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Asp Tyr Thr Ser Ser Asn 85 90 95 Val Asp Asn Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 81 <211> 119 <212> PRT <213> Secuencia artificial <220> <223> hu.9H5-H14.G54A VH <400> 81 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 20 25 30 Gly Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 35 40 45 Gly Phe Ile Gly Ser Ala Gly Phe Ala Tyr Tyr Ala Ser Trp Ala Lys 50 55 60 Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Asp Val Gly Gly Gly Lys Ser Leu Asp Ile Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 82 <211> 119 <212> PRT <213> Secuencia artificial <220> <223> hu.9H5-H14.G98Q VH <400> 82 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 20 25 30 Gly Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 35 40 45 Gly Phe Ile Gly Ser Gly Gly Phe Ala Tyr Tyr Ala Ser Trp Ala Lys 50 55 60 Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Asp Val Gln Gly Gly Lys Ser Leu Asp Ile Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 83 <211> 119 <212> PRT <213> Secuencia artificial <220> <223> hu.9H5-H14.G54A.G98Q VH <400> 83 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 20 25 30 Gly Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 35 40 45 Gly Phe Ile Gly Ser Ala Gly Phe Ala Tyr Tyr Ala Ser Trp Ala Lys 50 55 60 Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Asp Val Gln Gly Gly Lys Ser Leu Asp Ile Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 84 <211> 119 <212> PRT <213> Secuencia artificial <220> <223> hu.9H5-H14.Q39K VH <400> 84 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 20 25 30 Gly Val Ser Trp Val Arg Lys Ala Pro Gly Lys Gly Leu Glu Tyr Val 35 40 45 Gly Phe Ile Gly Ser Gly Gly Phe Ala Tyr Tyr Ala Ser Trp Ala Lys 50 55 60 Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Asp Val Gly Gly Gly Lys Ser Leu Asp Ile Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 85 <211> 119 <212> PRT <213> Secuencia artificial <220> <223> hu.9H5-H14.Q39K.G54A VH <400> 85 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 20 25 30 Gly Val Ser Trp Val Arg Lys Ala Pro Gly Lys Gly Leu Glu Tyr Val 35 40 45 Gly Phe Ile Gly Ser Ala Gly Phe Ala Tyr Tyr Ala Ser Trp Ala Lys 50 55 60 Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Asp Val Gly Gly Gly Lys Ser Leu Asp Ile Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 86 <211> 119 <212> PRT <213> Secuencia artificial <220> <223> hu.9H5-H14.Q39K.G98Q VH <400> 86 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 20 25 30 Gly Val Ser Trp Val Arg Lys Ala Pro Gly Lys Gly Leu Glu Tyr Val 35 40 45 Gly Phe Ile Gly Ser Gly Gly Phe Ala Tyr Tyr Ala Ser Trp Ala Lys 50 55 60 Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Asp Val Gln Gly Gly Lys Ser Leu Asp Ile Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 87 <211> 119 <212> PRT <213> Secuencia artificial <220> <223> hu.9H5-H14.Q39K.G54A.G98Q VH <400> 87 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 20 25 30 Gly Val Ser Trp Val Arg Lys Ala Pro Gly Lys Gly Leu Glu Tyr Val 35 40 45 Gly Phe Ile Gly Ser Ala Gly Phe Ala Tyr Tyr Ala Ser Trp Ala Lys 50 55 60 Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Asp Val Gln Gly Gly Lys Ser Leu Asp Ile Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 88 <211> 110 <212> PRT <213> Secuencia artificial <220> <223> hu.9H5-L4.H89V VL <400> 88 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Val Gln Asp Tyr Thr Ser Ser Asn 85 90 95 Val Asp Asn Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 89 <211> 110 <212> PRT <213> Secuencia artificial <220> <223> hu.9H5-L4.S95Y VL <400> 89 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Asp Tyr Thr Ser Tyr Asn 85 90 95 Val Asp Asn Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 90 <211> 110 <212> PRT <213> Secuencia artificial <220> <223> hu.9H5-L4.H89V.S95Y VL <400> 90 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Val Gln Asp Tyr Thr Ser Tyr Asn 85 90 95 Val Asp Asn Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 91 <211> 110 <212> PRT <213> Secuencia artificial <220> <223> hu.9H5-L4.Q38E VL <400> 91 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Ser Trp Tyr Gln Glu Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Asp Tyr Thr Ser Ser Asn 85 90 95 Val Asp Asn Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 92 <211> 110 <212> PRT <213> Secuencia artificial <220> <223> hu.9H5-L4.Q38E.H89V VL <400> 92 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Ser Trp Tyr Gln Glu Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Val Gln Asp Tyr Thr Ser Ser Asn 85 90 95 Val Asp Asn Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 93 <211> 110 <212> PRT <213> Secuencia artificial <220> <223> hu.9H5-L4.Q38E.S95Y VL <400> 93 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Ser Trp Tyr Gln Glu Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Asp Tyr Thr Ser Tyr Asn 85 90 95 Val Asp Asn Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 94 <211> 110 <212> PRT <213> Secuencia artificial <220> <223> hu.9H5-L4.Q38E.H89V.S95Y VL <400> 94 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Ser Trp Tyr Gln Glu Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Val Gln Asp Tyr Thr Ser Tyr Asn 85 90 95 Val Asp Asn Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 95 <211> 330 <212> PRT <213> Secuencia artificial <220> <223> región constante de la cadena pesada de IgG1 humana (hIgG1) <400> 95 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 1 5 10 15 Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 65 70 75 80 Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 100 105 110 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 115 120 125 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 130 135 140 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 145 150 155 160 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 165 170 175 Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 180 185 190 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 195 200 205 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 210 215 220 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 225 230 235 240 Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 245 250 255 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 260 265 270 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 275 280 285 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 290 295 300 Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 305 310 315 320 Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 325 330 <210> 96 <211> 330 <212> PRT <213> Secuencia artificial <220> <223> hIgG1.N297G.Knob(T366W). S183K <400> 96 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 1 5 10 15 Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Lys Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 65 70 75 80 Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 100 105 110 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 115 120 125 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 130 135 140 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 145 150 155 160 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 165 170 175 Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 180 185 190 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 195 200 205 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 210 215 220 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 225 230 235 240 Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr 245 250 255 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 260 265 270 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 275 280 285 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 290 295 300 Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 305 310 315 320 Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 325 330 <210> 97 <211> 330 <212> PRT <213> Secuencia artificial <220> <223> hIgG1.N297G.Hole(T366S. L368A.Y407V). S183E <400> 97 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 1 5 10 15 Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Glu Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 65 70 75 80 Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 100 105 110 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 115 120 125 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 130 135 140 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 145 150 155 160 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 165 170 175 Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 180 185 190 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 195 200 205 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 210 215 220 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 225 230 235 240 Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr 245 250 255 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 260 265 270 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 275 280 285 Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 290 295 300 Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 305 310 315 320 Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 325 330 <210> 98 <211> 330 <212> PRT <213> Secuencia artificial <220> <223> hIgG1.N297G.Knob(T366W). S183K.M428L.N434S <400> 98 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 1 5 10 15 Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Lys Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 65 70 75 80 Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 100 105 110 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 115 120 125 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 130 135 140 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 145 150 155 160 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 165 170 175 Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 180 185 190 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 195 200 205 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 210 215 220 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 225 230 235 240 Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr 245 250 255 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 260 265 270 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 275 280 285 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 290 295 300 Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr 305 310 315 320 Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 325 330 <210> 99 <211> 330 <212> PRT <213> Secuencia artificial <220> <223> hIgG1.N297G.Hole(T366S. L368A.Y407V).S183E. M428L.N434S <400> 99 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 1 5 10 15 Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Glu Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 65 70 75 80 Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 100 105 110 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 115 120 125 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 130 135 140 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 145 150 155 160 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 165 170 175 Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 180 185 190 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 195 200 205 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 210 215 220 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 225 230 235 240 Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr 245 250 255 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 260 265 270 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 275 280 285 Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 290 295 300 Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr 305 310 315 320 Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 325 330 <210> 100 <211> 291 <212> PRT <213> Macaca fascicularis <400> 100 Met Ala Thr Ala Arg Thr Pro Trp Met Trp Val Leu Cys Ala Leu Ile 1 5 10 15 Thr Ala Leu Leu Leu Gly Val Thr Glu His Val Leu Ala Asn Asp Asp 20 25 30 Val Ser Cys Asp Asn Pro Ser Asn Thr Val Pro Ser Gly Ser Asn Arg 35 40 45 Asp Val Gly Ala Gly Asp Asp Ala Arg Ser Asp Asp Ser Ser Ser Arg 50 55 60 Ile Ile Asn Gly Ser Asp Cys Asp Glu His Thr Gln Pro Trp Gln Ala 65 70 75 80 Ala Leu Leu Leu Gly Pro Asn Gln Leu Tyr Cys Gly Gly Val Leu Val 85 90 95 His Pro Gln Trp Leu Leu Thr Ala Ala His Cys Arg Lys Lys Val Phe 100 105 110 Arg Val Arg Leu Gly His Tyr Ser Leu Ser Pro Val Tyr Glu Ser Gly 115 120 125 Gln Gln Met Phe Gln Gly Ile Lys Ser Ile Pro His Pro Gly Tyr Ser 130 135 140 His Pro Gly His Ser Asn Asp Leu Met Leu Ile Lys Leu Asn Arg Arg 145 150 155 160 Ile His Ser Thr Lys Asp Val Arg Pro Ile Asn Val Ser Ser His Cys 165 170 175 Pro Ser Ala Gly Thr Lys Cys Leu Val Ser Gly Trp Gly Thr Thr Arg 180 185 190 Ser Pro Gln Val His Phe Pro Lys Val Leu Gln Cys Leu Asn Ile Ser 195 200 205 Val Leu Ser Gln Lys Arg Cys Glu Asp Ala Tyr Pro Arg Gln Ile Asp 210 215 220 Asp Thr Met Phe Cys Ala Gly Asp Glu Ala Gly Arg Asp Ser Cys Gln 225 230 235 240 Gly Asp Ser Gly Gly Pro Val Val Cys Asn Gly Ser Leu Gln Gly Leu 245 250 255 Val Ser Trp Gly Asp Tyr Pro Cys Ala Lys Pro Asn Arg Pro Gly Val 260 265 270 Tyr Thr Asn Leu Cys Lys Phe Thr Lys Trp Ile Gln Glu Thr Ile Gln 275 280 285 Ala Asn Ser 290 <210> 101 <211> 227 <212> PRT <213> Macaca fascicularis <400> 101 Ile Ile Asn Gly Ser Asp Cys Asp Glu His Thr Gln Pro Trp Gln Ala 1 5 10 15 Ala Leu Leu Leu Gly Pro Asn Gln Leu Tyr Cys Gly Gly Val Leu Val 20 25 30 His Pro Gln Trp Leu Leu Thr Ala Ala His Cys Arg Lys Lys Val Phe 35 40 45 Arg Val Arg Leu Gly His Tyr Ser Leu Ser Pro Val Tyr Glu Ser Gly 50 55 60 Gln Gln Met Phe Gln Gly Ile Lys Ser Ile Pro His Pro Gly Tyr Ser 65 70 75 80 His Pro Gly His Ser Asn Asp Leu Met Leu Ile Lys Leu Asn Arg Arg 85 90 95 Ile His Ser Thr Lys Asp Val Arg Pro Ile Asn Val Ser Ser His Cys 100 105 110 Pro Ser Ala Gly Thr Lys Cys Leu Val Ser Gly Trp Gly Thr Thr Arg 115 120 125 Ser Pro Gln Val His Phe Pro Lys Val Leu Gln Cys Leu Asn Ile Ser 130 135 140 Val Leu Ser Gln Lys Arg Cys Glu Asp Ala Tyr Pro Arg Gln Ile Asp 145 150 155 160 Asp Thr Met Phe Cys Ala Gly Asp Glu Ala Gly Arg Asp Ser Cys Gln 165 170 175 Gly Asp Ser Gly Gly Pro Val Val Cys Asn Gly Ser Leu Gln Gly Leu 180 185 190 Val Ser Trp Gly Asp Tyr Pro Cys Ala Lys Pro Asn Arg Pro Gly Val 195 200 205 Tyr Thr Asn Leu Cys Lys Phe Thr Lys Trp Ile Gln Glu Thr Ile Gln 210 215 220 Ala Asn Ser 225 <210> 102 <211> 107 <212> PRT <213> Secuencia artificial <220> <223> región constante de la cadena liviana kappa humana (hKappa) <400> 102 Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 1 5 10 15 Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 20 25 30 Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 35 40 45 Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 50 55 60 Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 65 70 75 80 Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 85 90 95 Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 100 105 <210> 103 <211> 107 <212> PRT <213> Secuencia artificial <220> <223> hKappa.V133E <400> 103 Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 1 5 10 15 Gln Leu Lys Ser Gly Thr Ala Ser Val Glu Cys Leu Leu Asn Asn Phe 20 25 30 Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 35 40 45 Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 50 55 60 Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 65 70 75 80 Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 85 90 95 Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 100 105 <210> 104 <211> 107 <212> PRT <213> Secuencia artificial <220> <223> hKappa.V133K <400> 104 Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 1 5 10 15 Gln Leu Lys Ser Gly Thr Ala Ser Val Lys Cys Leu Leu Asn Asn Phe 20 25 30 Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 35 40 45 Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 50 55 60 Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 65 70 75 80 Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 85 90 95 Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 100 105 <210> 105 <211> 120 <212> PRT <213> Secuencia artificial <220> <223> hu.10C5-H28.G33P VH <400> 105 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 20 25 30 Pro Val Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Thr Ser Asn Tyr Gly Val Ser Tyr Tyr Ala Ser Trp Ala 50 55 60 Lys Ser Arg Ser Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Val Tyr 65 70 75 80 Leu Gln Met Gly Ser Leu Arg Ala Glu Asp Met Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Asn Pro Asp Tyr Gly Tyr Ala Tyr Asp Ala Trp Gly Gln 100 105 110 Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 106 <211> 120 <212> PRT <213> Secuencia artificial <220> <223> hu.10C5-H28.G33P.N53V VH <400> 106 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 20 25 30 Pro Val Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Thr Ser Val Tyr Gly Val Ser Tyr Tyr Ala Ser Trp Ala 50 55 60 Lys Ser Arg Ser Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Val Tyr 65 70 75 80 Leu Gln Met Gly Ser Leu Arg Ala Glu Asp Met Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Asn Pro Asp Tyr Gly Tyr Ala Tyr Asp Ala Trp Gly Gln 100 105 110 Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 107 <211> 5 <212> PRT <213> Secuencia artificial <220> <223> CDRH1 <400> 107 Ser Tyr Pro Val Thr 1 5 <210> 108 <211> 458 <212> PRT <213> Secuencia artificial <220> <223> cadena pesada (HC) hu14H11c en hu.10C5VY.hu14H11c.L2H11 WT <400> 108 Glu Gln Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Ser 20 25 30 Tyr Tyr Met Ser Trp Val Arg Glu Ala Pro Gly Lys Gly Leu Glu Trp 35 40 45 Val Ser Ser Ile Tyr Ala Gly Ser Ser Gly Ala Pro Tyr Tyr Ala Gly 50 55 60 Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Ala Arg Glu Gly Phe Ala Glu Thr Gly Gly Tyr Gly Tyr Ala 100 105 110 Ala Tyr Phe Asn Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 115 120 125 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 130 135 140 Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 145 150 155 160 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 165 170 175 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 180 185 190 Leu Lys Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 195 200 205 Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 210 215 220 Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 225 230 235 240 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 245 250 255 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 260 265 270 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 275 280 285 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 290 295 300 Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 305 310 315 320 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 325 330 335 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 340 345 350 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 355 360 365 Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr 370 375 380 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 385 390 395 400 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 405 410 415 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 420 425 430 Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 435 440 445 Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 450 455 <210> 109 <211> 217 <212> PRT <213> Secuencia artificial <220> <223> cadena liviana (LC) hu14H11c en hu.10C5VY.hu14H11c.L2H11 WT <400> 109 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Leu Ala Ser Glu Asp Ile Ala Ser Ser 20 25 30 Val Ser Trp Tyr Gln Lys Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Ser Tyr Ser Ser 85 90 95 Thr Gly Thr Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 100 105 110 Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 115 120 125 Lys Ser Gly Thr Ala Ser Val Glu Cys Leu Leu Asn Asn Phe Tyr Pro 130 135 140 Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 145 150 155 160 Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 165 170 175 Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 180 185 190 Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 195 200 205 Thr Lys Ser Phe Asn Arg Gly Glu Cys 210 215 <210> 110 <211> 450 <212> PRT <213> Secuencia artificial <220> <223> cadena pesada (HC) hu.10C5VY en hu.10C5VY.hu14H11c.L2H11 WT <400> 110 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 20 25 30 Gly Val Thr Trp Val Arg Lys Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Thr Ser Val Tyr Gly Val Ser Tyr Tyr Ala Ser Trp Ala 50 55 60 Lys Ser Arg Ser Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Val Tyr 65 70 75 80 Leu Gln Met Gly Ser Leu Arg Ala Glu Asp Met Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Asn Pro Asp Tyr Gly Tyr Ala Tyr Asp Ala Trp Gly Gln 100 105 110 Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 115 120 125 Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 130 135 140 Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 145 150 155 160 Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 165 170 175 Leu Gln Ser Ser Gly Leu Tyr Ser Leu Glu Ser Val Val Thr Val Pro 180 185 190 Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 195 200 205 Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 210 215 220 Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 225 230 235 240 Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 245 250 255 Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 260 265 270 Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 275 280 285 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 290 295 300 Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 305 310 315 320 Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 325 330 335 Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 340 345 350 Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 355 360 365 Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 370 375 380 Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 385 390 395 400 Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp 405 410 415 Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 420 425 430 Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 435 440 445 Gly Lys 450 <210> 111 <211> 217 <212> PRT <213> Secuencia artificial <220> <223> cadena liviana (LC) hu.10C5VY en hu.10C5VY.hu14H11c.L2H11 WT <400> 111 Ala Ile Arg Met Thr Gln Ser Pro Ser Ser Phe Ser Ala Ser Thr Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Ser Asn Glu 20 25 30 Leu Ser Trp Tyr Gln Glu Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Tyr Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Gly Tyr Gly Ser Ser Gly 85 90 95 Val Glu Asn Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 100 105 110 Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 115 120 125 Lys Ser Gly Thr Ala Ser Val Lys Cys Leu Leu Asn Asn Phe Tyr Pro 130 135 140 Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 145 150 155 160 Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 165 170 175 Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 180 185 190 Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 195 200 205 Thr Lys Ser Phe Asn Arg Gly Glu Cys 210 215 <210> 112 <211> 458 <212> PRT <213> Secuencia artificial <220> <223> cadena pesada (HC) hu14H11c en hu.10C5VY.hu14H11c.L2H11 LS <400> 112 Glu Gln Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Ser 20 25 30 Tyr Tyr Met Ser Trp Val Arg Glu Ala Pro Gly Lys Gly Leu Glu Trp 35 40 45 Val Ser Ser Ile Tyr Ala Gly Ser Ser Gly Ala Pro Tyr Tyr Ala Gly 50 55 60 Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Ala Arg Glu Gly Phe Ala Glu Thr Gly Gly Tyr Gly Tyr Ala 100 105 110 Ala Tyr Phe Asn Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 115 120 125 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 130 135 140 Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 145 150 155 160 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 165 170 175 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 180 185 190 Leu Lys Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 195 200 205 Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 210 215 220 Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 225 230 235 240 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 245 250 255 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 260 265 270 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 275 280 285 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 290 295 300 Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 305 310 315 320 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 325 330 335 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 340 345 350 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 355 360 365 Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr 370 375 380 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 385 390 395 400 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 405 410 415 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 420 425 430 Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr 435 440 445 Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 450 455 <210> 113 <211> 217 <212> PRT <213> Secuencia artificial <220> <223> cadena liviana (LC) hu14H11c en hu.10C5VY.hu14H11c.L2H11 LS <400> 113 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Leu Ala Ser Glu Asp Ile Ala Ser Ser 20 25 30 Val Ser Trp Tyr Gln Lys Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Ser Tyr Ser Ser 85 90 95 Thr Gly Thr Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 100 105 110 Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 115 120 125 Lys Ser Gly Thr Ala Ser Val Glu Cys Leu Leu Asn Asn Phe Tyr Pro 130 135 140 Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 145 150 155 160 Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 165 170 175 Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 180 185 190 Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 195 200 205 Thr Lys Ser Phe Asn Arg Gly Glu Cys 210 215 <210> 114 <211> 450 <212> PRT <213> Secuencia artificial <220> <223> cadena pesada (HC) hu.10C5VY en hu.10C5VY.hu14H11c.L2H11 LS <400> 114 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 20 25 30 Gly Val Thr Trp Val Arg Lys Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Thr Ser Val Tyr Gly Val Ser Tyr Tyr Ala Ser Trp Ala 50 55 60 Lys Ser Arg Ser Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Val Tyr 65 70 75 80 Leu Gln Met Gly Ser Leu Arg Ala Glu Asp Met Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Asn Pro Asp Tyr Gly Tyr Ala Tyr Asp Ala Trp Gly Gln 100 105 110 Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 115 120 125 Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 130 135 140 Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 145 150 155 160 Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 165 170 175 Leu Gln Ser Ser Gly Leu Tyr Ser Leu Glu Ser Val Val Thr Val Pro 180 185 190 Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 195 200 205 Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 210 215 220 Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 225 230 235 240 Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 245 250 255 Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 260 265 270 Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 275 280 285 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 290 295 300 Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 305 310 315 320 Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 325 330 335 Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 340 345 350 Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 355 360 365 Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 370 375 380 Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 385 390 395 400 Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp 405 410 415 Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Leu His 420 425 430 Glu Ala Leu His Ser His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 435 440 445 Gly Lys 450 <210> 115 <211> 217 <212> PRT <213> Secuencia artificial <220> <223> cadena liviana (LC) hu.10C5VY en hu.10C5VY.hu14H11c.L2H11 LS <400> 115 Ala Ile Arg Met Thr Gln Ser Pro Ser Ser Phe Ser Ala Ser Thr Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Ser Asn Glu 20 25 30 Leu Ser Trp Tyr Gln Glu Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Tyr Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Gly Tyr Gly Ser Ser Gly 85 90 95 Val Glu Asn Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 100 105 110 Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 115 120 125 Lys Ser Gly Thr Ala Ser Val Lys Cys Leu Leu Asn Asn Phe Tyr Pro 130 135 140 Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 145 150 155 160 Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 165 170 175 Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 180 185 190 Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 195 200 205 Thr Lys Ser Phe Asn Arg Gly Glu Cys 210 215 <210> 116 <211> 126 <212> PRT <213> Secuencia artificial <220> <223> región variable de la cadena pesada (VH) rb.14H11 <400> 116 Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Ser Tyr 20 25 30 Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Ala Ser Ile Tyr Ala Gly Ser Ser Gly Ala Pro Tyr Tyr Ala Gly Trp 50 55 60 Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Ala Val Thr 65 70 75 80 Leu Gln Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 85 90 95 Ala Arg Glu Gly Phe Ala Glu Thr Gly Gly Tyr Gly Tyr Ala Ala Tyr 100 105 110 Phe Asn Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 117 <211> 330 <212> PRT <213> Secuencia artificial <220> <223> hIgG1.N297G.Knob(T366W). S183E <400> 117 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 1 5 10 15 Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Glu Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 65 70 75 80 Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 100 105 110 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 115 120 125 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 130 135 140 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 145 150 155 160 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 165 170 175 Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 180 185 190 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 195 200 205 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 210 215 220 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 225 230 235 240 Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr 245 250 255 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 260 265 270 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 275 280 285 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 290 295 300 Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 305 310 315 320 Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 325 330 <210> 118 <211> 330 <212> PRT <213> Secuencia artificial <220> <223> hIgG1.N297G.Hole(T366S. L368A.Y407V). S183K <400> 118 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 1 5 10 15 Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Lys Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 65 70 75 80 Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 100 105 110 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 115 120 125 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 130 135 140 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 145 150 155 160 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 165 170 175 Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 180 185 190 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 195 200 205 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 210 215 220 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 225 230 235 240 Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr 245 250 255 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 260 265 270 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 275 280 285 Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 290 295 300 Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 305 310 315 320 Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 325 330 <210> 119 <211> 330 <212> PRT <213> Secuencia artificial <220> <223> hIgG1.N297G.Knob(T366W). S183E.M428L.N434S <400> 119 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 1 5 10 15 Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Glu Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 65 70 75 80 Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 100 105 110 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 115 120 125 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 130 135 140 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 145 150 155 160 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 165 170 175 Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 180 185 190 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 195 200 205 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 210 215 220 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 225 230 235 240 Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr 245 250 255 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 260 265 270 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 275 280 285 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 290 295 300 Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr 305 310 315 320 Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 325 330 <210> 120 <211> 330 <212> PRT <213> Secuencia artificial <220> <223> hIgG1.N297G.Hole(T366S. L368A.Y407V).S183K. M428L.N434S <400> 120 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 1 5 10 15 Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Lys Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 65 70 75 80 Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 100 105 110 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 115 120 125 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 130 135 140 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 145 150 155 160 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 165 170 175 Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 180 185 190 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 195 200 205 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 210 215 220 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 225 230 235 240 Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr 245 250 255 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 260 265 270 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 275 280 285 Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 290 295 300 Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr 305 310 315 320 Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 325 330 <210> 121 <211> 10 <212> PRT <213> Secuencia artificial <220> <223> sustrato de KLK7 <220> <221> MOD_RES <222> (7)..(7) <223> Nva <400> 121 Arg Pro Lys Pro Val Glu Xaa Trp Arg Lys 1 5 10 <210> 122 <211> 29 <212> PRT <213> Secuencia artificial <220> <223> rb.14H11c VH FR1 <400> 122 Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser 20 25 <210> 123 <211> 30 <212> PRT <213> Secuencia artificial <220> <223> FR1 <400> 123 Glu Gln Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser 20 25 30 <210> 124 <211> 30 <212> PRT <213> Secuencia artificial <220> <223> FR1 <400> 124 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser 20 25 30 <210> 125 <211> 30 <212> PRT <213> Secuencia artificial <220> <223> hu.14H11c.V3-53*4.H1 VH FR1 <400> 125 Glu Gln Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser 20 25 30 <210> 126 <211> 30 <212> PRT <213> Secuencia artificial <220> <223> hu.14H11c.V3-23.H1 VH FR1 <400> 126 Glu Gln Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser 20 25 30 <210> 127 <211> 30 <212> PRT <213> Secuencia artificial <220> <223> hu.14H11c.V3-33*2.H1 VH FR1 <400> 127 Glu Gln Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser 20 25 30 <210> 128 <211> 30 <212> PRT <213> Secuencia artificial <220> <223> hu.14H11c.V3-21.H1 VH FR1 <400> 128 Glu Gln Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser 20 25 30 <210> 129 <211> 14 <212> PRT <213> Secuencia artificial <220> <223> FR2 <400> 129 Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Ala 1 5 10 <210> 130 <211> 14 <212> PRT <213> Secuencia artificial <220> <223> hu.14H11c.V3-53*1.H3 VH FR2 <400> 130 Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 1 5 10 <210> 131 <211> 14 <212> PRT <213> Secuencia artificial <220> <223> hu.14H11c.V3-53*1.H4 VH FR2 <400> 131 Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Ser 1 5 10 <210> 132 <211> 14 <212> PRT <213> Secuencia artificial <220> <223> FR2 <400> 132 Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 1 5 10 <210> 133 <211> 14 <212> PRT <213> Secuencia artificial <220> <223> hu.14H11c-H11.Q39E VH FR2 <400> 133 Trp Val Arg Glu Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 1 5 10 <210> 134 <211> 31 <212> PRT <213> Secuencia artificial <220> <223> rb.14H11c VH FR3 <400> 134 Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Ala Val Thr Leu Gln Met 1 5 10 15 Ser Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg 20 25 30 <210> 135 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> FR3 <400> 135 Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr Val Tyr Leu Gln 1 5 10 15 Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg 20 25 30 <210> 136 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> hu.14H11c.V3-53*1.H5 VH FR3 <400> 136 Arg Phe Thr Ile Ser Arg Asp Ser Ser Lys Asn Thr Val Tyr Leu Gln 1 5 10 15 Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg 20 25 30 <210> 137 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> hu.14H11c.V3-53*1.H6 VH FR3 <400> 137 Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln 1 5 10 15 Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg 20 25 30 <210> 138 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> hu.14H11c.V3-53*1.H7 VH FR3 <400> 138 Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr Leu Tyr Leu Gln 1 5 10 15 Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg 20 25 30 <210> 139 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> hu.14H11c.V3-53*1.H8 VH FR3 <400> 139 Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr Val Tyr Leu Gln 1 5 10 15 Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 20 25 30 <210> 140 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> FR3 <400> 140 Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 1 5 10 15 Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 20 25 30 <210> 141 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> hu.14H11c.V3-53*4.H1 VH FR3 <400> 141 Arg Phe Thr Ile Ser Lys His Ser Ser Lys Asn Thr Val Tyr Leu Gln 1 5 10 15 Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg 20 25 30 <210> 142 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> hu.14H11c.V3-33*2.H1 VH FR3 <400> 142 Arg Phe Thr Ile Ser Lys Asp Ser Ser Thr Asn Thr Val Phe Leu Gln 1 5 10 15 Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg 20 25 30 <210> 143 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> hu.14H11c.V3-21.H1 VH FR3 <400> 143 Arg Phe Thr Ile Ser Lys Asp Thr Ala Ser Thr Ser Val Tyr Leu Gln 1 5 10 15 Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg 20 25 30 <210> 144 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> FR4 <400> 144 Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 1 5 10 <210> 145 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> FR4 <400> 145 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 1 5 10 <210> 146 <211> 23 <212> PRT <213> Secuencia artificial <220> <223> rb.14H11c VL FR1 <400> 146 Ala Ile Glu Met Thr Gln Ser Pro Pro Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Glu Thr Val Arg Ile Arg Cys 20 <210> 147 <211> 23 <212> PRT <213> Secuencia artificial <220> <223> FR1 <400> 147 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys 20 <210> 148 <211> 23 <212> PRT <213> Secuencia artificial <220> <223> hu.14H11c.K1-5.L1 VL FR1 <400> 148 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys 20 <210> 149 <211> 23 <212> PRT <213> Secuencia artificial <220> <223> hu.14H11c.K1-8.L1 VL FR1 <400> 149 Ala Ile Arg Met Thr Gln Ser Pro Ser Ser Phe Ser Ala Ser Thr Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys 20 <210> 150 <211> 23 <212> PRT <213> Secuencia artificial <220> <223> hu.14H11c.K1-6.L1 VL FR1 <400> 150 Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys 20 <210> 151 <211> 15 <212> PRT <213> Secuencia artificial <220> <223> rb.14H11c VL FR2 <400> 151 Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Thr Leu Leu Ile Tyr 1 5 10 15 <210> 152 <211> 15 <212> PRT <213> Secuencia artificial <220> <223> FR2 <400> 152 Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile Tyr 1 5 10 15 <210> 153 <211> 15 <212> PRT <213> Secuencia artificial <220> <223> FR2 <400> 153 Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 1 5 10 15 <210> 154 <211> 15 <212> PRT <213> Secuencia artificial <220> <223> hu.14H11c-L2.Q38K VL FR2 <400> 154 Trp Tyr Gln Lys Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 1 5 10 15 <210> 155 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> rb.14H11c VL FR3 <400> 155 Gly Val Pro Pro Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Tyr Thr 1 5 10 15 Leu Thr Ile Gly Gly Val Gln Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 20 25 30 <210> 156 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> FR3 <400> 156 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 1 5 10 15 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 20 25 30 <210> 157 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> FR3 <400> 157 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 1 5 10 15 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 20 25 30 <210> 158 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> hu.14H11c.K1-5.L1 VL FR3 <400> 158 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Tyr Thr 1 5 10 15 Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys 20 25 30 <210> 159 <211> 10 <212> PRT <213> Secuencia artificial <220> <223> rb.14H11c VL FR4 <400> 159 Phe Gly Ala Gly Thr Lys Val Glu Ile Lys 1 5 10 <210> 160 <211> 10 <212> PRT <213> Secuencia artificial <220> <223> FR4 <400> 160 Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 1 5 10 <210> 161 <211> 30 <212> PRT <213> Secuencia artificial <220> <223> FR1 <400> 161 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser 20 25 30 <210> 162 <211> 14 <212> PRT <213> Secuencia artificial <220> <223> FR2 <400> 162 Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 1 5 10 <210> 163 <211> 14 <212> PRT <213> Secuencia artificial <220> <223> hu.10C5-H28.Q39K.N54V VH FR2 <400> 163 Trp Val Arg Lys Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 1 5 10 <210> 164 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> FR3 <400> 164 Arg Ser Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Val Tyr Leu Gln 1 5 10 15 Met Gly Ser Leu Arg Ala Glu Asp Met Ala Val Tyr Tyr Cys Ala Arg 20 25 30 <210> 165 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> FR4 <400> 165 Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 1 5 10 <210> 166 <211> 23 <212> PRT <213> Secuencia artificial <220> <223> Secuencia LC-FR1 de ejemplo <400> 166 Ala Ile Arg Met Thr Gln Ser Pro Ser Ser Phe Ser Ala Ser Thr Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys 20 <210> 167 <211> 15 <212> PRT <213> Secuencia artificial <220> <223> FR2 <400> 167 Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 1 5 10 15 <210> 168 <211> 15 <212> PRT <213> Secuencia artificial <220> <223> FR2 <400> 168 Trp Tyr Gln Glu Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 1 5 10 15 <210> 169 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> FR3 <400> 169 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 1 5 10 15 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 20 25 30 <210> 170 <211> 10 <212> PRT <213> Secuencia artificial <220> <223> FR4 <400> 170 Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 1 5 10 <210> 171 <211> 30 <212> PRT <213> Secuencia artificial <220> <223> FR1 <400> 171 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser 20 25 30 <210> 172 <211> 14 <212> PRT <213> Secuencia artificial <220> <223> FR2 <400> 172 Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val Gly 1 5 10 <210> 173 <211> 14 <212> PRT <213> Secuencia artificial <220> <223> FR2 <400> 173 Trp Val Arg Lys Ala Pro Gly Lys Gly Leu Glu Tyr Val Gly 1 5 10 <210> 174 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> FR3 <400> 174 Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 1 5 10 15 Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 20 25 30 <210> 175 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> FR4 <400> 175 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 1 5 10 <210> 176 <211> 23 <212> PRT <213> Secuencia artificial <220> <223> FR1 <400> 176 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys 20 <210> 177 <211> 15 <212> PRT <213> Secuencia artificial <220> <223> FR2 <400> 177 Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 1 5 10 15 <210> 178 <211> 15 <212> PRT <213> Secuencia artificial <220> <223> FR2 <400> 178 Trp Tyr Gln Glu Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 1 5 10 15 <210> 179 <211> 32 <212> PRT <213> Secuencia artificial <220> <223> FR3 <400> 179 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 1 5 10 15 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 20 25 30 <210> 180 <211> 10 <212> PRT <213> Secuencia artificial <220> <223> FR4 <400> 180 Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 1 5 10 <210> 181 <211> 227 <212> PRT <213> Secuencia artificial <220> <223> hIgG1 simulada.N297G.Knob(T366W). S183K para constructos de un brazo <400> 181 Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 1 5 10 15 Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 20 25 30 Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 35 40 45 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 50 55 60 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr 65 70 75 80 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 85 90 95 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 100 105 110 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 115 120 125 Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 130 135 140 Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 145 150 155 160 Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 165 170 175 Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 180 185 190 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 195 200 205 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 210 215 220 Pro Gly Lys 225 <210> 182 <211> 227 <212> PRT <213> Secuencia artificial <220> <223> hIgG1 simulada. N297G.Hole(T366S. L368A.Y407V). S183E para constructos de un brazo <400> 182 Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 1 5 10 15 Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 20 25 30 Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 35 40 45 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 50 55 60 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr 65 70 75 80 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 85 90 95 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 100 105 110 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 115 120 125 Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 130 135 140 Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 145 150 155 160 Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 165 170 175 Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 180 185 190 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 195 200 205 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 210 215 220 Pro Gly Lys 225 <210> 183 <211> 328 <212> PRT <213> Secuencia artificial <220> <223> región constante de la cadena pesada de IgG1 humana (hIgG1) GK <400> 183 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 1 5 10 15 Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 65 70 75 80 Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 100 105 110 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 115 120 125 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 130 135 140 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 145 150 155 160 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 165 170 175 Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 180 185 190 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 195 200 205 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 210 215 220 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 225 230 235 240 Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 245 250 255 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 260 265 270 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 275 280 285 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 290 295 300 Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 305 310 315 320 Gln Lys Ser Leu Ser Leu Ser Pro 325 <210> 184 <211> 328 <212> PRT <213> Secuencia artificial <220> <223> hIgG1.N297G.Knob(T366W). S183K GK <400> 184 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 1 5 10 15 Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Lys Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 65 70 75 80 Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 100 105 110 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 115 120 125 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 130 135 140 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 145 150 155 160 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 165 170 175 Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 180 185 190 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 195 200 205 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 210 215 220 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 225 230 235 240 Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr 245 250 255 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 260 265 270 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 275 280 285 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 290 295 300 Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 305 310 315 320 Gln Lys Ser Leu Ser Leu Ser Pro 325 <210> 185 <211> 328 <212> PRT <213> Secuencia artificial <220> <223> hIgG1.N297G.Hole(T366S. L368A.Y407V). S183EGK <400> 185 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 1 5 10 15 Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Glu Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 65 70 75 80 Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 100 105 110 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 115 120 125 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 130 135 140 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 145 150 155 160 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 165 170 175 Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 180 185 190 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 195 200 205 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 210 215 220 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 225 230 235 240 Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr 245 250 255 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 260 265 270 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 275 280 285 Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 290 295 300 Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 305 310 315 320 Gln Lys Ser Leu Ser Leu Ser Pro 325 <210> 186 <211> 328 <212> PRT <213> Secuencia artificial <220> <223> hIgG1.N297G.Knob(T366W). S183K.M428L.N434S GK <400> 186 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 1 5 10 15 Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Lys Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 65 70 75 80 Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 100 105 110 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 115 120 125 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 130 135 140 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 145 150 155 160 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 165 170 175 Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 180 185 190 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 195 200 205 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 210 215 220 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 225 230 235 240 Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr 245 250 255 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 260 265 270 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 275 280 285 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 290 295 300 Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr 305 310 315 320 Gln Lys Ser Leu Ser Leu Ser Pro 325 <210> 187 <211> 328 <212> PRT <213> Secuencia artificial <220> <223> hIgG1.N297G.Hole(T366S. L368A.Y407V).S183E. M428L.N434S GK <400> 187 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 1 5 10 15 Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Glu Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 65 70 75 80 Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 100 105 110 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 115 120 125 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 130 135 140 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 145 150 155 160 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 165 170 175 Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 180 185 190 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 195 200 205 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 210 215 220 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 225 230 235 240 Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr 245 250 255 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 260 265 270 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 275 280 285 Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 290 295 300 Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr 305 310 315 320 Gln Lys Ser Leu Ser Leu Ser Pro 325 <210> 188 <211> 328 <212> PRT <213> Secuencia artificial <220> <223> hIgG1.N297G.Knob(T366W). S183E GK <400> 188 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 1 5 10 15 Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Glu Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 65 70 75 80 Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 100 105 110 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 115 120 125 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 130 135 140 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 145 150 155 160 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 165 170 175 Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 180 185 190 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 195 200 205 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 210 215 220 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 225 230 235 240 Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr 245 250 255 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 260 265 270 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 275 280 285 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 290 295 300 Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 305 310 315 320 Gln Lys Ser Leu Ser Leu Ser Pro 325 <210> 189 <211> 328 <212> PRT <213> Secuencia artificial <220> <223> hIgG1.N297G.Hole(T366S. L368A.Y407V). S183K GK <400> 189 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 1 5 10 15 Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Lys Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 65 70 75 80 Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 100 105 110 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 115 120 125 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 130 135 140 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 145 150 155 160 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 165 170 175 Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 180 185 190 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 195 200 205 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 210 215 220 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 225 230 235 240 Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr 245 250 255 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 260 265 270 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 275 280 285 Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 290 295 300 Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 305 310 315 320 Gln Lys Ser Leu Ser Leu Ser Pro 325 <210> 190 <211> 328 <212> PRT <213> Secuencia artificial <220> <223> hIgG1.N297G.Knob(T366W). S183E.M428L.N434S GK <400> 190 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 1 5 10 15 Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Glu Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 65 70 75 80 Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 100 105 110 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 115 120 125 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 130 135 140 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 145 150 155 160 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 165 170 175 Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 180 185 190 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 195 200 205 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 210 215 220 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 225 230 235 240 Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr 245 250 255 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 260 265 270 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 275 280 285 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 290 295 300 Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr 305 310 315 320 Gln Lys Ser Leu Ser Leu Ser Pro 325 <210> 191 <211> 328 <212> PRT <213> Secuencia artificial <220> <223> hIgG1.N297G.Hole(T366S. L368A.Y407V).S183K. M428L.N434S GK <400> 191 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 1 5 10 15 Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Lys Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 65 70 75 80 Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 100 105 110 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 115 120 125 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 130 135 140 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 145 150 155 160 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 165 170 175 Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 180 185 190 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 195 200 205 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 210 215 220 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 225 230 235 240 Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr 245 250 255 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 260 265 270 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 275 280 285 Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 290 295 300 Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr 305 310 315 320 Gln Lys Ser Leu Ser Leu Ser Pro 325 <210> 192 <211> 456 <212> PRT <213> Secuencia artificial <220> <223> cadena pesada (HC) hu14H11c en hu.10C5VY.hu14H11c.L2H11 WT GK <400> 192 Glu Gln Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Ser 20 25 30 Tyr Tyr Met Ser Trp Val Arg Glu Ala Pro Gly Lys Gly Leu Glu Trp 35 40 45 Val Ser Ser Ile Tyr Ala Gly Ser Ser Gly Ala Pro Tyr Tyr Ala Gly 50 55 60 Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Ala Arg Glu Gly Phe Ala Glu Thr Gly Gly Tyr Gly Tyr Ala 100 105 110 Ala Tyr Phe Asn Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 115 120 125 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 130 135 140 Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 145 150 155 160 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 165 170 175 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 180 185 190 Leu Lys Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 195 200 205 Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 210 215 220 Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 225 230 235 240 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 245 250 255 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 260 265 270 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 275 280 285 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 290 295 300 Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 305 310 315 320 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 325 330 335 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 340 345 350 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 355 360 365 Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr 370 375 380 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 385 390 395 400 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 405 410 415 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 420 425 430 Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 435 440 445 Gln Lys Ser Leu Ser Leu Ser Pro 450 455 <210> 193 <211> 448 <212> PRT <213> Secuencia artificial <220> <223> hu.10C5VY cadena pesada (HC) en hu.10C5VY.hu14H11c.L2H11 WT GK <400> 193 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 20 25 30 Gly Val Thr Trp Val Arg Lys Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Thr Ser Val Tyr Gly Val Ser Tyr Tyr Ala Ser Trp Ala 50 55 60 Lys Ser Arg Ser Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Val Tyr 65 70 75 80 Leu Gln Met Gly Ser Leu Arg Ala Glu Asp Met Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Asn Pro Asp Tyr Gly Tyr Ala Tyr Asp Ala Trp Gly Gln 100 105 110 Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 115 120 125 Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 130 135 140 Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 145 150 155 160 Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 165 170 175 Leu Gln Ser Ser Gly Leu Tyr Ser Leu Glu Ser Val Val Thr Val Pro 180 185 190 Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 195 200 205 Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 210 215 220 Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 225 230 235 240 Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 245 250 255 Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 260 265 270 Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 275 280 285 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 290 295 300 Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 305 310 315 320 Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 325 330 335 Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 340 345 350 Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 355 360 365 Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 370 375 380 Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 385 390 395 400 Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp 405 410 415 Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 420 425 430 Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 435 440 445 <210> 194 <211> 456 <212> PRT <213> Secuencia artificial <220> <223> cadena pesada (HC) hu14H11c en hu.10C5VY.hu14H11c.L2H11 LS GK <400> 194 Glu Gln Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Ser 20 25 30 Tyr Tyr Met Ser Trp Val Arg Glu Ala Pro Gly Lys Gly Leu Glu Trp 35 40 45 Val Ser Ser Ile Tyr Ala Gly Ser Ser Gly Ala Pro Tyr Tyr Ala Gly 50 55 60 Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Ala Arg Glu Gly Phe Ala Glu Thr Gly Gly Tyr Gly Tyr Ala 100 105 110 Ala Tyr Phe Asn Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 115 120 125 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 130 135 140 Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 145 150 155 160 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 165 170 175 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 180 185 190 Leu Lys Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 195 200 205 Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 210 215 220 Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 225 230 235 240 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 245 250 255 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 260 265 270 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 275 280 285 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 290 295 300 Glu Gln Tyr Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 305 310 315 320 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 325 330 335 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 340 345 350 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 355 360 365 Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr 370 375 380 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 385 390 395 400 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 405 410 415 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 420 425 430 Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr 435 440 445 Gln Lys Ser Leu Ser Leu Ser Pro 450 455 <210> 195 <211> 448 <212> PRT <213> Secuencia artificial <220> <223> cadena pesada (HC) hu.10C5VY en hu.10C5VY.hu14H11c.L2H11 LS GK <400> 195 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 20 25 30 Gly Val Thr Trp Val Arg Lys Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Thr Ser Val Tyr Gly Val Ser Tyr Tyr Ala Ser Trp Ala 50 55 60 Lys Ser Arg Ser Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Val Tyr 65 70 75 80 Leu Gln Met Gly Ser Leu Arg Ala Glu Asp Met Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Asn Pro Asp Tyr Gly Tyr Ala Tyr Asp Ala Trp Gly Gln 100 105 110 Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 115 120 125 Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 130 135 140 Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 145 150 155 160 Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 165 170 175 Leu Gln Ser Ser Gly Leu Tyr Ser Leu Glu Ser Val Val Thr Val Pro 180 185 190 Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 195 200 205 Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 210 215 220 Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 225 230 235 240 Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 245 250 255 Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 260 265 270 Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 275 280 285 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 290 295 300 Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 305 310 315 320 Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 325 330 335 Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 340 345 350 Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 355 360 365 Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 370 375 380 Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 385 390 395 400 Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp 405 410 415 Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Leu His 420 425 430 Glu Ala Leu His Ser His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 435 440 445 <210> 196 <211> 14 <212> PRT <213> Secuencia artificial <220> <223> SFTI 21705 (también denominado SFTI-KLK7) <400> 196 Gly Lys Cys Leu Phe Ser Asn Pro Pro Ile Cys Phe Pro Asn 1 5 10 <210> 197 <211> 314 <212> PRT <213> Secuencia artificial <220> <223> SPINK9.SRE.Fc <400> 197 Gly Ser Ile Glu Ser Ala Lys Gln Thr Lys Gln Met Val Asp Cys Ser 1 5 10 15 His Tyr Lys Lys Leu Pro Pro Gly Gln Gln Arg Phe Cys His Arg Glu 20 25 30 Tyr Asp Pro Ile Cys Gly Ser Asp Gly Lys Thr Tyr Lys Asn Asp Cys 35 40 45 Phe Phe Cys Ser Lys Val Lys Lys Thr Asp Gly Thr Leu Lys Phe Val 50 55 60 His Phe Gly Lys Cys Gly Asn Ser Arg Ala Gln Val Thr Asp Lys Lys 65 70 75 80 Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys 85 90 95 Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 100 105 110 Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys 115 120 125 Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp 130 135 140 Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg 145 150 155 160 Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln 165 170 175 His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn 180 185 190 Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly 195 200 205 Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu 210 215 220 Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met 225 230 235 240 Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu 245 250 255 Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe 260 265 270 Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn 275 280 285 Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr 290 295 300 Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 305 310 <210> 198 <211> 237 <212> PRT <213> Secuencia artificial <220> <223> Fab de cadena pesada rb.14H11c <400> 198 Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 1 5 10 15 Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Ser Tyr 20 25 30 Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Ala Ser Ile Tyr Ala Gly Ser Ser Gly Ala Pro Tyr Tyr Ala Gly Trp 50 55 60 Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Ala Val Thr 65 70 75 80 Leu Gln Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 85 90 95 Ala Arg Glu Gly Phe Ala Glu Thr Gly Gly Tyr Gly Tyr Ala Ala Tyr 100 105 110 Phe Asn Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Gly Gln 115 120 125 Pro Lys Ala Pro Ser Val Phe Pro Leu Ala Pro Cys Cys Gly Asp Thr 130 135 140 Pro Ser Ser Thr Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Leu Pro 145 150 155 160 Glu Pro Val Thr Val Thr Trp Asn Ser Gly Thr Leu Thr Asn Gly Val 165 170 175 Arg Thr Phe Pro Ser Val Arg Gln Ser Ser Gly Leu Tyr Ser Leu Ser 180 185 190 Ser Val Val Ser Val Thr Ser Ser Ser Gln Pro Val Thr Cys Asn Val 195 200 205 Ala His Pro Ala Thr Asn Thr Lys Val Asp Lys Thr Val Ala Pro Ser 210 215 220 Thr Cys Ser Lys Pro Thr His His His His His His Pro 225 230 235 <210> 199 <211> 215 <212> PRT <213> Secuencia artificial <220> <223> Fab de cadena liviana rb.14H11c <400> 199 Ala Ile Glu Met Thr Gln Ser Pro Pro Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Glu Thr Val Arg Ile Arg Cys Leu Ala Ser Glu Asp Ile Ala Asn Ser 20 25 30 Val Ser Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Thr Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Asn Leu Glu Ser Gly Val Pro Pro Arg Phe Thr Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Gly Gly Val Gln Ala 65 70 75 80 Glu Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Ser Tyr Ser Ser 85 90 95 Thr Gly Thr Ala Phe Gly Ala Gly Thr Lys Val Glu Ile Asn Arg Asp 100 105 110 Pro Val Ala Pro Ser Val Leu Leu Phe Pro Pro Ser Lys Glu Glu Leu 115 120 125 Thr Thr Gly Thr Ala Thr Ile Val Cys Val Ala Asn Lys Phe Tyr Pro 130 135 140 Ser Asp Ile Thr Val Thr Trp Lys Val Asp Gly Thr Thr Gln Gln Ser 145 150 155 160 Gly Ile Glu Asn Ser Lys Thr Pro Gln Ser Pro Glu Asp Asn Thr Tyr 165 170 175 Asn Leu Ser Ser Thr Leu Thr Leu Thr Ser Thr Gln Tyr Asn Ser His 180 185 190 Lys Glu Tyr Thr Cys Lys Val Thr Gln Gly Thr Thr Ser Val Val Gln 195 200 205 Ser Phe Asn Arg Gly Asp Cys 210 215