Listado de Secuencias <110> ALECAR LLC <120> MOLÉCULA DE FUSIÓN DE ECD DE SIGLEC-9 Y MÉADOS DE USO DE ESTAS <130> 01209-0008-00PCT <140> PCT/US20/58687 <141> 2020-11-03 <150> US 62/930,227 <151> 2019-11-04 <150> US 63/014,940 <151> 2020-04-24 <150> US 63/092,753 <151> 2020-10-16 <160> 239 <170> PatentIn version 3.5 <210> 1 <211> 463 <212> PRT <213> Homo sapiens <400> 1 Met Leu Leu Leu Leu Leu Pro Leu Leu Trp Gly Arg Glu Arg Ala Glu 1 5 10 15 Gly Gln Thr Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Leu Gln Ser Lys Ala Thr Ser Gly Val Thr Gln Gly Val Val Gly Gly 340 345 350 Ala Gly Ala Thr Ala Leu Val Phe Leu Ser Phe Cys Val Ile Phe Val 355 360 365 Val Val Arg Ser Cys Arg Lys Lys Ser Ala Arg Pro Ala Ala Gly Val 370 375 380 Gly Asp Thr Gly Ile Glu Asp Ala Asn Ala Val Arg Gly Ser Ala Ser 385 390 395 400 Gln Gly Pro Leu Thr Glu Pro Trp Ala Glu Asp Ser Pro Pro Asp Gln 405 410 415 Pro Pro Pro Ala Ser Ala Arg Ser Ser Val Gly Glu Gly Glu Leu Gln 420 425 430 Tyr Ala Ser Leu Ser Phe Gln Met Val Lys Pro Trp Asp Ser Arg Gly 435 440 445 Gln Glu Ala Thr Asp Thr Glu Tyr Ser Glu Ile Lys Ile His Arg 450 455 460 <210> 2 <211> 444 <212> PRT <213> Homo sapiens <400> 2 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Trp Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Leu Gln Ser 305 310 315 320 Lys Ala Thr Ser Gly Val Thr Gln Gly Val Val Gly Gly Ala Gly Ala 325 330 335 Thr Ala Leu Val Phe Leu Ser Phe Cys Val Ile Phe Val Val Val Arg 340 345 350 Ser Cys Arg Lys Lys Ser Ala Arg Pro Ala Ala Gly Val Gly Asp Thr 355 360 365 Gly Ile Glu Asp Ala Asn Ala Val Arg Gly Ser Ala Ser Gln Gly Pro 370 375 380 Leu Thr Glu Pro Trp Ala Glu Asp Ser Pro Pro Asp Gln Pro Pro Pro 385 390 395 400 Ala Ser Ala Arg Ser Ser Val Gly Glu Gly Glu Leu Gln Tyr Ala Ser 405 410 415 Leu Ser Phe Gln Met Val Lys Pro Trp Asp Ser Arg Gly Gln Glu Ala 420 425 430 Thr Asp Thr Glu Tyr Ser Glu Ile Lys Ile His Arg 435 440 <210> 3 <211> 5 <212> PRT <213> Secuencia Artificial <220> <223> enlazador <400> 3 Ala Leu Thr His Arg 1 5 <210> 4 <211> 6 <212> PRT <213> Secuencia Artificial <220> <223> enlazador <400> 4 Leu Asn Val Ser Tyr Pro 1 5 <210> 5 <211> 6 <212> PRT <213> Secuencia Artificial <220> <223> Motivo ITIM <400> 5 Leu Gln Tyr Ala Ser Leu 1 5 <210> 6 <211> 6 <212> PRT <213> Secuencia Artificial <220> <223> Motivo de tipo SLAM <400> 6 Thr Glu Tyr Ser Glu Ile 1 5 <210> 7 <211> 121 <212> PRT <213> Homo sapiens <400> 7 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Trp Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr 115 120 <210> 8 <211> 8 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-7 loop <400> 8 Val Asp Ser Gln Thr Asp Ser Asp 1 5 <210> 9 <211> 8 <212> PRT <213> Secuencia Artificial <220> <223> Bucle de Siglec-9 <400> 9 Ser His Gly Trp Ile Tyr Pro Gly 1 5 <210> 10 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9-Fc original (WIYP); S9.1-hIgG1 (sin la secuencia señal) <400> 10 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Trp Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 11 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9-Fc DIEG; S9.2-hIgG1 <400> 11 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Asp Ile 20 25 30 Glu Gly Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 12 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9-Fc SIET; S9.3-hIgG1 <400> 12 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Ser Ile 20 25 30 Glu Thr Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 13 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9-Fc SIEP; S9.4-hIgG1 <400> 13 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Ser Ile 20 25 30 Glu Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 14 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9-Fc DIEP; S9.5-hIgG1 <400> 14 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Asp Ile 20 25 30 Glu Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 15 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9-Fc YQES; S9.6-hIgG1 <400> 15 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Tyr Gln 20 25 30 Glu Ser Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 16 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9-Fc THET; S9.7-hIgG1 <400> 16 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Thr His 20 25 30 Glu Thr Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 17 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9-Fc L23T H26S H80Y L82E; S9.8-hIgG1 <400> 17 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Thr 1 5 10 15 Cys Val Ser Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Trp Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe Tyr Leu Glu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 18 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9-Fc L23T H26T H80Y L82D; S9.9-hIgG1 <400> 18 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Thr 1 5 10 15 Cys Val Thr Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Trp Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe Tyr Leu Asp Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 19 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9-Fc S35D W38T; S9.10-hIgG1 <400> 19 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Asp His Gly Thr Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 20 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9-Fc S35D W38E; S9.11-hIgG1 <400> 20 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Asp His Gly Glu Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 21 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9-Fc W38S I39H Y40H; S9.12-hIgG1 <400> 21 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Ser His 20 25 30 His Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 22 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9-Fc S35D W38Q I39H Y40E; S9.13-hIgG1 <400> 22 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Asp His Gly Gln His 20 25 30 Glu Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 23 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9-Fc S35T W38Q I39H Y40E; S9.14-hIgG1 <400> 23 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Thr His Gly Ser His 20 25 30 Glu Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 24 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9-Fc S35D W38E I39T; S9.15-hIgG1 <400> 24 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Asp His Gly Glu Thr 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 25 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9-Fc S35N W38E I39T; S9.16-hIgG1 <400> 25 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Asn His Gly Thr Glu 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 26 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9-Fc S35H W38T I39T Y40T; S9.17-hIgG1 <400> 26 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro His His Gly Thr Thr 20 25 30 Thr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 27 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9-Fc S35H W38S I39T Y40T; S9.18-hIgG1 <400> 27 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro His His Gly Ser Thr 20 25 30 Thr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 28 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9-Fc W38G I39T Y40E; S9.19-hIgG1 <400> 28 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Gly Thr 20 25 30 Glu Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 29 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9-Fc S8D K9Y L10T W116E; S9.20-hIgG1 <400> 29 Asp Tyr Thr Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Trp Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Glu Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 30 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9-Fc S8D K9Y L10Q W116N; S9.21-hIgG1 <400> 30 Asp Tyr Gln Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Trp Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Asn Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 31 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9-Fc S8E K9Y L10T W116E; S9.22-hIgG1 <400> 31 Glu Tyr Thr Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Trp Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Glu Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 32 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9-Fc WIYP a QTDS; S9.23-hIgG1 <400> 32 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Gln Thr 20 25 30 Asp Ser Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 33 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9-Fc GWIYP a SQTDS; S9.24-hIgG1 <400> 33 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Ser Gln Thr 20 25 30 Asp Ser Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 34 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9-Fc SHGWIYPG a VDSQTDSD; S9.25-hIgG1 <400> 34 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Val Asp Ser Gln Thr 20 25 30 Asp Ser Asp Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 35 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9-Fc SHGWIYPG a VHGQIDSD; S9.26-hIgG1 <400> 35 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Val His Gly Gln Ile 20 25 30 Asp Ser Asp Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 36 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9-Fc SHGWIYPG a VHSQIDSD; S9.27-hIgG1 <400> 36 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Val His Ser Gln Ile 20 25 30 Asp Ser Asp Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 37 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9-Fc SHGWIYPG a VDSQIDSD; S9.28-hIgG1 <400> 37 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Val Asp Ser Gln Ile 20 25 30 Asp Ser Asp Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 38 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9-Fc SHGWIYPG a SDSQIDSD; S9.29-hIgG1 <400> 38 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser Asp Ser Gln Ile 20 25 30 Asp Ser Asp Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 39 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9-Fc SHGWIYPG a VDGQIDSD; S9.30-hIgG1 <400> 39 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Val Asp Gly Gln Ile 20 25 30 Asp Ser Asp Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 40 <211> 586 <212> PRT <213> Secuencia Artificial <220> <223> S9.A-hIgG1 <220> <221> Aminoácidos <222> (1)..(19) <223> Secuencia señal <220> <221> Aminoácidos <222> (20)..(586) <223> Secuencia madura <400> 40 Met Leu Leu Leu Leu Leu Pro Leu Leu Trp Gly Arg Glu Arg Ala Glu 1 5 10 15 Gly Gln Thr Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Leu Gln Ser Lys Ala Thr Ser Gly Val Thr Gln Gly Asp Ile Glu Gly 340 345 350 Arg Met Asp Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 355 360 365 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 370 375 380 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 385 390 395 400 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 405 410 415 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 420 425 430 Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 435 440 445 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 450 455 460 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 465 470 475 480 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 485 490 495 Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 500 505 510 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 515 520 525 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 530 535 540 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 545 550 555 560 Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 565 570 575 Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 580 585 <210> 41 <211> 586 <212> PRT <213> Secuencia Artificial <220> <223> S9.A-hIgG1 NSLF <220> <221> Aminoácidos <222> (1)..(19) <223> Secuencia señal <220> <221> Aminoaácidos <222> (20)..(586) <223> Secuencia madura <400> 41 Met Leu Leu Leu Leu Leu Pro Leu Leu Trp Gly Arg Glu Arg Ala Glu 1 5 10 15 Gly Gln Thr Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Leu Gln Ser Lys Ala Thr Ser Gly Val Thr Gln Gly Asp Ile Glu Gly 340 345 350 Arg Met Asp Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 355 360 365 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 370 375 380 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 385 390 395 400 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 405 410 415 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 420 425 430 Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 435 440 445 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Ser 450 455 460 Lys Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 465 470 475 480 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 485 490 495 Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 500 505 510 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 515 520 525 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 530 535 540 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 545 550 555 560 Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 565 570 575 Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 580 585 <210> 42 <211> 586 <212> PRT <213> Secuencia Artificial <220> <223> S9.A-hIgG1 LALAPS <220> <221> Aminoácidos <222> (1)..(19) <223> Secuencia señal <220> <221> Aminoácidos <222> (20)..(586) <223> Secuencia madura <400> 42 Met Leu Leu Leu Leu Leu Pro Leu Leu Trp Gly Arg Glu Arg Ala Glu 1 5 10 15 Gly Gln Thr Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Leu Gln Ser Lys Ala Thr Ser Gly Val Thr Gln Gly Asp Ile Glu Gly 340 345 350 Arg Met Asp Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 355 360 365 Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 370 375 380 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 385 390 395 400 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 405 410 415 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 420 425 430 Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 435 440 445 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 450 455 460 Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 465 470 475 480 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 485 490 495 Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 500 505 510 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 515 520 525 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 530 535 540 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 545 550 555 560 Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 565 570 575 Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 580 585 <210> 43 <211> 576 <212> PRT <213> Secuencia Artificial <220> <223> S9.A-mIgG1 <220> <221> Aminoácidos <222> (1)..(19) <223> Secuencia señal <220> <221> Aminoácidos <222> (20)..(576) <223> Secuencia madura <400> 43 Met Leu Leu Leu Leu Leu Pro Leu Leu Trp Gly Arg Glu Arg Ala Glu 1 5 10 15 Gly Gln Thr Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Leu Gln Ser Lys Ala Thr Ser Gly Val Thr Gln Gly Asp Ile Glu Gly 340 345 350 Arg Met Asp Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser 355 360 365 Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu 370 375 380 Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro 385 390 395 400 Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala 405 410 415 Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val 420 425 430 Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe 435 440 445 Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr 450 455 460 Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile 465 470 475 480 Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys 485 490 495 Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp 500 505 510 Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asn 515 520 525 Thr Asn Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser 530 535 540 Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly 545 550 555 560 Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 565 570 575 <210> 44 <211> 587 <212> PRT <213> Secuencia Artificial <220> <223> S9.B-mIgG2a <220> <221> Aminoácidos <222> (1)..(19) <223> Secuencia señal <220> <221> Aminoácidos <222> (20)..(587) <223> Secuencia madura <400> 44 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Leu Gln Ser Lys Ala Thr Ser Gly Val Thr Gln Gly Gly Gly Gly Gly 340 345 350 Ser Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys 355 360 365 Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro 370 375 380 Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr 385 390 395 400 Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser 405 410 415 Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His 420 425 430 Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile 435 440 445 Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn 450 455 460 Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys 465 470 475 480 Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu 485 490 495 Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe 500 505 510 Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu 515 520 525 Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr 530 535 540 Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg 545 550 555 560 Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His 565 570 575 Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 580 585 <210> 45 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> S9.1-hIgG1 NSLF <400> 45 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Ser Lys Ala 435 440 445 Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 46 <211> 577 <212> PRT <213> Secuencia Artificial <220> <223> S9.1-hIgG4 S228P <400> 46 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Leu Gln Ser Lys Ala Thr Ser Gly Val Thr Gln Gly Glu Ser Lys Tyr 340 345 350 Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro 355 360 365 Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 370 375 380 Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 385 390 395 400 Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 405 410 415 Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 420 425 430 Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 435 440 445 Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 450 455 460 Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 465 470 475 480 Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 485 490 495 Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 500 505 510 Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 515 520 525 Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 530 535 540 Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 545 550 555 560 Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 565 570 575 Lys <210> 47 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> S9.1-hIgG1 K322A <400> 47 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 48 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> Secuencia señal (SS)-Siglec-9-Fc original (WIYP); SS-S9.1-hIgG1 <400> 48 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 49 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> SS-Siglec-9-Fc DIEG; SS-S9.2-hIgG1 <400> 49 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Asp Ile Glu Gly Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 50 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> SS-Siglec-9-Fc SIET; SS-S9.3-hIgG1 <400> 50 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Ser Ile Glu Thr Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 51 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> SS-Siglec-9-Fc SIEP; SS-S9.4-hIgG1 <400> 51 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Ser Ile Glu Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 52 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> SS-Siglec-9-Fc DIEP; SS-S9.5-hIgG1 <400> 52 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Asp Ile Glu Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 53 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> SS-Siglec-9-Fc YQES; SS-S9.6-hIgG1 <400> 53 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Tyr Gln Glu Ser Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 54 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> SS-Siglec-9-Fc THET; SS-S9.7-hIgG1 <400> 54 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Thr His Glu Thr Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 55 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> SS-Siglec-9-Fc L23T H26S H80Y L82E; SS-S9.8-hIgG1 <400> 55 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Thr Cys Val Ser Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe Tyr Leu Glu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 56 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> SS-Siglec-9-Fc L23T H26T H80Y L82D; SS-S9.9-hIgG1 <400> 56 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Thr Cys Val Thr Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe Tyr Leu Asp Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 57 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> SS-Siglec-9-Fc S35D W38T; SS-S9.10-hIgG1 <400> 57 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Asp His 35 40 45 Gly Thr Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 58 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> SS-Siglec-9-Fc S35D W38E; SS-S9.11-hIgG1 <400> 58 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Asp His 35 40 45 Gly Glu Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 59 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> SS-Siglec-9-Fc W38S I39H Y40H; SS-S9.12-hIgG1 <400> 59 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Ser His His Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 60 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> SS-Siglec-9-Fc S35D W38Q I39H Y40E; SS-S9.13-hIgG1 <400> 60 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Asp His 35 40 45 Gly Gln His Glu Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 61 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> SS-Siglec-9-Fc S35T W38Q I39H Y40E; SS-S9.14-hIgG1 <400> 61 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Thr His 35 40 45 Gly Ser His Glu Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 62 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> SS-Siglec-9-Fc S35D W38E I39T; SS-S9.15-hIgG1 <400> 62 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Asp His 35 40 45 Gly Glu Thr Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 63 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> SS-Siglec-9-Fc S35N W38E I39T; SS-S9.16-hIgG1 <400> 63 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Asn His 35 40 45 Gly Thr Glu Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 64 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> SS-Siglec-9-Fc S35H W38T I39T Y40T; SS-S9.17-hIgG1 <400> 64 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro His His 35 40 45 Gly Thr Thr Thr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 65 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> SS-Siglec-9-Fc S35H W38S I39T Y40T; SS-S9.18-hIgG1 <400> 65 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro His His 35 40 45 Gly Ser Thr Thr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 66 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> SS-Siglec-9-Fc W38G I39T Y40E; SS-S9.19-hIgG1 <400> 66 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Gly Thr Glu Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 67 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> SS-Siglec-9-Fc S8D K9Y L10T W116E; SS-S9.20-hIgG1 <400> 67 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Tyr Thr Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Glu 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 68 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> SS-Siglec-9-Fc S8D K9Y L10Q W116N; SS-S9.21-hIgG1 <400> 68 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Tyr Gln Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Asn 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 69 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> SS-Siglec-9-Fc S8E K9Y L10T W116E; SS-S9.22-hIgG1 <400> 69 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Glu Tyr Thr Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Glu 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 70 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> SS-Siglec-9-Fc WIYP a QTDS; SS-S9.23-hIgG1 <400> 70 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Gln Thr Asp Ser Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 71 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> SS-Siglec-9-Fc GWIYP a SQTDS; SS-S9.24-hIgG1 <400> 71 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Ser Gln Thr Asp Ser Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 72 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> SS-Siglec-9-Fc SHGWIYPG a VDSQTDSD; SS-S9.25-hIgG1 <400> 72 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Val Asp 35 40 45 Ser Gln Thr Asp Ser Asp Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 73 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> SS-Siglec-9-Fc SHGWIYPG a VHGQIDSD; SS-S9.26-hIgG1 <400> 73 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Val His 35 40 45 Gly Gln Ile Asp Ser Asp Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 74 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> SS-Siglec-9-Fc SHGWIYPG a VHSQIDSD; SS-S9.27-hIgG1 <400> 74 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Val His 35 40 45 Ser Gln Ile Asp Ser Asp Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 75 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> SS-Siglec-9-Fc SHGWIYPG a VDSQIDSD; SS-S9.28-hIgG1 <400> 75 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Val Asp 35 40 45 Ser Gln Ile Asp Ser Asp Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 76 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> SS-Siglec-9-Fc SHGWIYPG a SDSQIDSD; SS-S9.29-hIgG1 <400> 76 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser Asp 35 40 45 Ser Gln Ile Asp Ser Asp Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 77 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> SS-Siglec-9-Fc SHGWIYPG a VDGQIDSD; SS-S9.30-hIgG1 <400> 77 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Val Asp 35 40 45 Gly Gln Ile Asp Ser Asp Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 78 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9 original (WIYP); S9.1 (sin Secuencia señal ) <400> 78 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Trp Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 79 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9 DIEG; S9.2 <400> 79 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Asp Ile 20 25 30 Glu Gly Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 80 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9 SIET; S9.3 <400> 80 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Ser Ile 20 25 30 Glu Thr Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 81 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9 SIEP; S9.4 <400> 81 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Ser Ile 20 25 30 Glu Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 82 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9 DIEP; S9.5 <400> 82 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Asp Ile 20 25 30 Glu Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 83 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9 YQES; S9.6 <400> 83 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Tyr Gln 20 25 30 Glu Ser Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 84 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9 THET; S9.7 <400> 84 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Thr His 20 25 30 Glu Thr Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 85 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9 L23T H26S H80Y L82E; S9.8 <400> 85 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Thr 1 5 10 15 Cys Val Ser Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Trp Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe Tyr Leu Glu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 86 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9 L23T H26T H80Y L82D; S9.9 <400> 86 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Thr 1 5 10 15 Cys Val Thr Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Trp Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe Tyr Leu Asp Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 87 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9 S35D W38T; S9.10 <400> 87 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Asp His Gly Thr Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 88 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9 S35D W38E; S9.11 <400> 88 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Asp His Gly Glu Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 89 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9 W38S I39H Y40H; S9.12 <400> 89 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Ser His 20 25 30 His Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 90 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9 S35D W38Q I39H Y40E; S9.13 <400> 90 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Asp His Gly Gln His 20 25 30 Glu Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 91 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9 S35T W38Q I39H Y40E; S9.14 <400> 91 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Thr His Gly Ser His 20 25 30 Glu Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 92 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9 S35D W38E I39T; S9.15 <400> 92 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Asp His Gly Glu Thr 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 93 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9 S35N W38E I39T; S9.16 <400> 93 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Asn His Gly Thr Glu 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 94 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9 S35H W38T I39T Y40T; S9.17 <400> 94 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro His His Gly Thr Thr 20 25 30 Thr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 95 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9 S35H W38S I39T Y40T; S9.18 <400> 95 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro His His Gly Ser Thr 20 25 30 Thr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 96 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9 W38G I39T Y40E; S9.19 <400> 96 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Gly Thr 20 25 30 Glu Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 97 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9 S8D K9Y L10T W116E; S9.20 <400> 97 Asp Tyr Thr Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Trp Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Glu Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 98 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9 S8D K9Y L10Q W116N; S9.21 <400> 98 Asp Tyr Gln Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Trp Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Asn Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 99 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9 S8E K9Y L10T W116E; S9.22 <400> 99 Glu Tyr Thr Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Trp Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Glu Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 100 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9 WIYP a QTDS; S9.23 <400> 100 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Gln Thr 20 25 30 Asp Ser Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 101 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9 GWIYP a SQTDS; S9.24 <400> 101 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Ser Gln Thr 20 25 30 Asp Ser Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 102 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9 SHGWIYPG a VDSQTDSD; S9.25 <400> 102 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Val Asp Ser Gln Thr 20 25 30 Asp Ser Asp Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 103 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9 SHGWIYPG a VHGQIDSD; S9.26 <400> 103 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Val His Gly Gln Ile 20 25 30 Asp Ser Asp Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 104 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9 SHGWIYPG a VHSQIDSD; S9.27 <400> 104 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Val His Ser Gln Ile 20 25 30 Asp Ser Asp Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 105 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9 SHGWIYPG a VDSQIDSD; S9.28 <400> 105 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Val Asp Ser Gln Ile 20 25 30 Asp Ser Asp Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 106 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9 SHGWIYPG a SDSQIDSD; S9.29 <400> 106 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser Asp Ser Gln Ile 20 25 30 Asp Ser Asp Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 107 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> Siglec-9 SHGWIYPG a VDGQIDSD; S9.30 <400> 107 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Val Asp Gly Gln Ile 20 25 30 Asp Ser Asp Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 108 <211> 121 <212> PRT <213> Secuencia Artificial <220> <223> Dominio IgV de Siglec-9 original (WIYP); S9.1-IgV (sin secuencia señal) <400> 108 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Trp Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr 115 120 <210> 109 <211> 121 <212> PRT <213> Secuencia Artificial <220> <223> Dominio IgV de Siglec-9 DIEG; S9.2-IgV <400> 109 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Asp Ile 20 25 30 Glu Gly Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr 115 120 <210> 110 <211> 121 <212> PRT <213> Secuencia Artificial <220> <223> Dominio IgV de Siglec-9 SIET; S9.3-IgV <400> 110 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Ser Ile 20 25 30 Glu Thr Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr 115 120 <210> 111 <211> 121 <212> PRT <213> Secuencia Artificial <220> <223> Dominio IgV de Siglec-9 SIEP; S9.4-IgV <400> 111 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Ser Ile 20 25 30 Glu Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr 115 120 <210> 112 <211> 121 <212> PRT <213> Secuencia Artificial <220> <223> Dominio IgV de Siglec-9 DIEP; S9.5-IgV <400> 112 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Asp Ile 20 25 30 Glu Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr 115 120 <210> 113 <211> 121 <212> PRT <213> Secuencia Artificial <220> <223> Dominio IgV de Siglec-9 YQES; S9.6-IgV <400> 113 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Tyr Gln 20 25 30 Glu Ser Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr 115 120 <210> 114 <211> 121 <212> PRT <213> Secuencia Artificial <220> <223> Dominio IgV de Siglec-9 THET; S9.7-IgV <400> 114 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Thr His 20 25 30 Glu Thr Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr 115 120 <210> 115 <211> 121 <212> PRT <213> Secuencia Artificial <220> <223> Dominio IgV de Siglec-9 L23T H26S H80Y L82E; S9.8-IgV <400> 115 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Thr 1 5 10 15 Cys Val Ser Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Trp Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe Tyr Leu Glu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr 115 120 <210> 116 <211> 121 <212> PRT <213> Secuencia Artificial <220> <223> Dominio IgV de Siglec-9 L23T H26T H80Y L82D; S9.9-IgV <400> 116 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Thr 1 5 10 15 Cys Val Thr Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Trp Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe Tyr Leu Asp Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr 115 120 <210> 117 <211> 121 <212> PRT <213> Secuencia Artificial <220> <223> Dominio IgV de Siglec-9 S35D W38T; S9.10-IgV <400> 117 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Asp His Gly Thr Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr 115 120 <210> 118 <211> 121 <212> PRT <213> Secuencia Artificial <220> <223> Dominio IgV de Siglec-9 S35D W38E; S9.11-IgV <400> 118 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Asp His Gly Glu Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr 115 120 <210> 119 <211> 121 <212> PRT <213> Secuencia Artificial <220> <223> Dominio IgV de Siglec-9 W38S I39H Y40H; S9.12-IgV <400> 119 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Ser His 20 25 30 His Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr 115 120 <210> 120 <211> 121 <212> PRT <213> Secuencia Artificial <220> <223> Dominio IgV de Siglec-9 S35D W38Q I39H Y40E; S9.13-IgV <400> 120 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Asp His Gly Gln His 20 25 30 Glu Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr 115 120 <210> 121 <211> 121 <212> PRT <213> Secuencia Artificial <220> <223> Dominio IgV de Siglec-9 S35T W38Q I39H Y40E; S9.14-IgV <400> 121 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Thr His Gly Ser His 20 25 30 Glu Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr 115 120 <210> 122 <211> 121 <212> PRT <213> Secuencia Artificial <220> <223> Dominio IgV de Siglec-9 S35D W38E I39T; S9.15-IgV <400> 122 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Asp His Gly Glu Thr 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr 115 120 <210> 123 <211> 121 <212> PRT <213> Secuencia Artificial <220> <223> Dominio IgV de Siglec-9 S35N W38E I39T; S9.16-IgV <400> 123 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Asn His Gly Thr Glu 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr 115 120 <210> 124 <211> 121 <212> PRT <213> Secuencia Artificial <220> <223> Dominio IgV de Siglec-9 S35H W38T I39T Y40T; S9.17-IgV <400> 124 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro His His Gly Thr Thr 20 25 30 Thr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr 115 120 <210> 125 <211> 121 <212> PRT <213> Secuencia Artificial <220> <223> Dominio IgV de Siglec-9 S35H W38S I39T Y40T; S9.18-IgV <400> 125 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro His His Gly Ser Thr 20 25 30 Thr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr 115 120 <210> 126 <211> 121 <212> PRT <213> Secuencia Artificial <220> <223> Dominio IgV de Siglec-9 W38G I39T Y40E; S9.19-IgV <400> 126 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Gly Thr 20 25 30 Glu Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr 115 120 <210> 127 <211> 121 <212> PRT <213> Secuencia Artificial <220> <223> Dominio IgV de Siglec-9 S8D K9Y L10T W116E; S9.20-IgV <400> 127 Asp Tyr Thr Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Trp Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Glu Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr 115 120 <210> 128 <211> 121 <212> PRT <213> Secuencia Artificial <220> <223> Dominio IgV de Siglec-9 S8D K9Y L10Q W116N; S9.21-IgV <400> 128 Asp Tyr Gln Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Trp Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Asn Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr 115 120 <210> 129 <211> 121 <212> PRT <213> Secuencia Artificial <220> <223> Dominio IgV de Siglec-9 S8E K9Y L10T W116E; S9.22-IgV <400> 129 Glu Tyr Thr Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Trp Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Glu Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr 115 120 <210> 130 <211> 121 <212> PRT <213> Secuencia Artificial <220> <223> Dominio IgV de Siglec-9 WIYP a QTDS; S9.23-IgV <400> 130 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Gln Thr 20 25 30 Asp Ser Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr 115 120 <210> 131 <211> 121 <212> PRT <213> Secuencia Artificial <220> <223> Dominio IgV de Siglec-9 GWIYP a SQTDS; S9.24-IgV <400> 131 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Ser Gln Thr 20 25 30 Asp Ser Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr 115 120 <210> 132 <211> 121 <212> PRT <213> Secuencia Artificial <220> <223> Dominio IgV de Siglec-9 SHGWIYPG a VDSQTDSD; S9.25-IgV <400> 132 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Val Asp Ser Gln Thr 20 25 30 Asp Ser Asp Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr 115 120 <210> 133 <211> 121 <212> PRT <213> Secuencia Artificial <220> <223> Dominio IgV de Siglec-9 SHGWIYPG a VHGQIDSD; S9.26-IgV <400> 133 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Val His Gly Gln Ile 20 25 30 Asp Ser Asp Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr 115 120 <210> 134 <211> 121 <212> PRT <213> Secuencia Artificial <220> <223> Dominio IgV de Siglec-9 SHGWIYPG a VHSQIDSD; S9.27-IgV <400> 134 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Val His Ser Gln Ile 20 25 30 Asp Ser Asp Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr 115 120 <210> 135 <211> 121 <212> PRT <213> Secuencia Artificial <220> <223> Dominio IgV de Siglec-9 SHGWIYPG a VDSQIDSD; S9.28-IgV <400> 135 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Val Asp Ser Gln Ile 20 25 30 Asp Ser Asp Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr 115 120 <210> 136 <211> 121 <212> PRT <213> Secuencia Artificial <220> <223> Dominio IgV de Siglec-9 SHGWIYPG a SDSQIDSD; S9.29-IgV <400> 136 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser Asp Ser Gln Ile 20 25 30 Asp Ser Asp Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr 115 120 <210> 137 <211> 121 <212> PRT <213> Secuencia Artificial <220> <223> Dominio IgV de Siglec-9 SHGWIYPG a VDGQIDSD; S9.30-IgV <400> 137 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Val Asp Gly Gln Ile 20 25 30 Asp Ser Asp Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr 115 120 <210> 138 <211> 348 <212> PRT <213> Secuencia Artificial <220> <223> SSopt-S9.A ECD (con la Secuencia señal optimizada) <400> 138 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Leu Gln Ser Lys Ala Thr Ser Gly Val Thr Gln Gly 340 345 <210> 139 <211> 586 <212> PRT <213> Secuencia Artificial <220> <223> SSopt-S9.A ECD-hIgG1 <220> <221> Aminoácidos <222> (1)..(19) <223> Secuencia señal optimizada <220> <221> Aminoácidos <222> (349)..(355) <223> Secuencia enlazadora entre ECD y el dominio Fc de hIgG1 <400> 139 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Leu Gln Ser Lys Ala Thr Ser Gly Val Thr Gln Gly Asp Ile Glu Gly 340 345 350 Arg Met Asp Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 355 360 365 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 370 375 380 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 385 390 395 400 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 405 410 415 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 420 425 430 Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 435 440 445 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 450 455 460 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 465 470 475 480 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 485 490 495 Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 500 505 510 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 515 520 525 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 530 535 540 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 545 550 555 560 Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 565 570 575 Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 580 585 <210> 140 <211> 19 <212> PRT <213> Secuencia Artificial <220> <223> Secuencia señal natural <400> 140 Met Leu Leu Leu Leu Leu Pro Leu Leu Trp Gly Arg Glu Arg Ala Glu 1 5 10 15 Gly Gln Thr <210> 141 <211> 19 <212> PRT <213> Secuencia Artificial <220> <223> Secuencia señal optimizada <400> 141 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser <210> 142 <211> 232 <212> PRT <213> Secuencia Artificial <220> <223> IgG1 de tipo salvaje <400> 142 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 1 5 10 15 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 20 25 30 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 35 40 45 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 50 55 60 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 65 70 75 80 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 85 90 95 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 100 105 110 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 115 120 125 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 130 135 140 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 145 150 155 160 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 165 170 175 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 180 185 190 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 195 200 205 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 210 215 220 Ser Leu Ser Leu Ser Pro Gly Lys 225 230 <210> 143 <211> 232 <212> PRT <213> Secuencia Artificial <220> <223> IgG1 NSLF <400> 143 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 1 5 10 15 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 20 25 30 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 35 40 45 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 50 55 60 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 65 70 75 80 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 85 90 95 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Ser Lys Ala 100 105 110 Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 115 120 125 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 130 135 140 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 145 150 155 160 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 165 170 175 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 180 185 190 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 195 200 205 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 210 215 220 Ser Leu Ser Leu Ser Pro Gly Lys 225 230 <210> 144 <211> 232 <212> PRT <213> Secuencia Artificial <220> <223> IgG1 K322A <400> 144 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 1 5 10 15 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 20 25 30 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 35 40 45 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 50 55 60 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 65 70 75 80 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 85 90 95 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala 100 105 110 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 115 120 125 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 130 135 140 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 145 150 155 160 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 165 170 175 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 180 185 190 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 195 200 205 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 210 215 220 Ser Leu Ser Leu Ser Pro Gly Lys 225 230 <210> 145 <211> 229 <212> PRT <213> Secuencia Artificial <220> <223> IgG4 <400> 145 Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 1 5 10 15 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 20 25 30 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 35 40 45 Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 50 55 60 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 65 70 75 80 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 85 90 95 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 100 105 110 Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 115 120 125 Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 130 135 140 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 145 150 155 160 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 165 170 175 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 180 185 190 Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 195 200 205 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 210 215 220 Leu Ser Leu Gly Lys 225 <210> 146 <211> 229 <212> PRT <213> Secuencia Artificial <220> <223> IgG4 S228P <400> 146 Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 1 5 10 15 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 20 25 30 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 35 40 45 Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 50 55 60 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 65 70 75 80 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 85 90 95 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 100 105 110 Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 115 120 125 Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 130 135 140 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 145 150 155 160 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 165 170 175 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 180 185 190 Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 195 200 205 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 210 215 220 Leu Ser Leu Gly Lys 225 <210> 147 <211> 12 <212> PRT <213> Secuencia Artificial <220> <223> Región proximal de la membrana del ECD de Siglec-9 <400> 147 Leu Gln Ser Lys Ala Thr Ser Gly Val Thr Gln Gly 1 5 10 <210> 148 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> S9.32 - W38T - hIgGI <400> 148 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Thr Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 149 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> S9.33 - W38E - hIgG1 <400> 149 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Glu Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 150 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> S9.34 - W38S - hIgG1 <400> 150 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Ser Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 151 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> S9.35 - W38A - hIgG1 <400> 151 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Ala Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 152 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> S9.36 - W38R - hIgG1 <400> 152 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Arg Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 153 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> S9.37 - W38Q - hIgG1 <400> 153 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Gln Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 154 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> S9.38 - W38K - hIgG1 <400> 154 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Lys Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 155 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> S9.39 - W38S_Y40T - hIgG1 <400> 155 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Ser Ile 20 25 30 Thr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 156 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> S9.41 - L_ER_R - hIgG1 <400> 156 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Glu Arg 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Arg Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 157 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> S9.42 - D_SI_R - hIgG1 <400> 157 Ser Lys Asp Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Ser Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Arg Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 158 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> S9.43 - L_KI_R - hIgG1 <400> 158 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Lys Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Arg Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 159 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> S9.44 - T_EI_E - hIgG1 <400> 159 Ser Lys Thr Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Glu Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Glu Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 160 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> S9.45 - S_QI_R - hIgG1 <400> 160 Ser Lys Ser Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Gln Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Arg Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 161 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> S9.47 - R_SS_I_T - hIgG1 <400> 161 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Trp Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Arg Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Ser Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Thr Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 162 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> S9.48 - R_DS_I_T - hIgG1 <400> 162 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Trp Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Arg Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Asp Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Thr Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 163 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> S9.49 - G_VT_Q_T - hIgG1 <400> 163 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Trp Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Thr Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Gln Pro Thr Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 164 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> S9.50 - N_TT_I_Q - hIgG1 <400> 164 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Trp Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Asn Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Thr Thr Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 165 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> S9.51 - G_VK_I_E - hIgG1 <400> 165 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Trp Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Lys Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Glu Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 166 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> S9.52 - R_SS_Q_T - hIgG1 <400> 166 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Trp Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Arg Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Ser Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Gln Pro Thr Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 167 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> S9.53 - G_SK_Q_E - hIgG1 <400> 167 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Trp Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Ser Lys Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Gln Pro Glu Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 168 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> S9.36 - W38R - hIgG1 NSLF <400> 168 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Arg Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Ser Lys Ala Phe Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 169 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> S9.37 - W38Q - hIgG1 NSLF <400> 169 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Gln Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Ser Lys Ala Phe Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 170 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> S9.38 - W38K - hIgG1 NSLF <400> 170 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Lys Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Ser Lys Ala Phe Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 171 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> S9.32 (SS) - W38T - hIgG1 <400> 171 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Thr Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 172 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> S9.33 (SS) - W38E - hIgG1 <400> 172 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Glu Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 173 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> S9.34 (SS) - W38S - hIgG1 <400> 173 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Ser Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 174 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> S9.35 (SS) - W38A - hIgG1 <400> 174 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Ala Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 175 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> S9.36 (SS) - W38R - hIgG1 <400> 175 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Arg Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 176 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> S9.37 (SS) - W38Q - hIgG1 <400> 176 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Gln Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 177 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> S9.38 (SS) - W38K - hIgG1 <400> 177 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Lys Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 178 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> S9.39 (SS) - W38S_Y40T - hIgG1 <400> 178 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Ser Ile Thr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 179 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> S9.41 (SS) - L_ER_R - hIgG1 <400> 179 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Glu Arg Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Arg 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 180 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> S9.42 (SS) - D_SI_R - hIgG1 <400> 180 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Asp Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Ser Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Arg 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 181 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> S9.43 (SS) - L_KI_R - hIgG1 <400> 181 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Lys Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Arg 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 182 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> S9.44 (SS) - T_EI_E - hIgG1 <400> 182 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Thr Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Glu Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Glu 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 183 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> S9.45 (SS) - S_QI_R - hIgG1 <400> 183 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Ser Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Gln Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Arg 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 184 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> S9.47 (SS) - R_SS_I_T - hIgG1 <400> 184 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Arg Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Ser Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Thr Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 185 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> S9.48 (SS) - R_DS_I_T - hIgG1 <400> 185 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Arg Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Asp Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Thr Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 186 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> S9.49 (SS) - G_VT_Q_T - hIgG1 <400> 186 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Thr Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Gln Pro Thr Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 187 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> S9.50 (SS) - N_TT_I_Q - hIgG1 <400> 187 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Asn Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Thr Thr Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 188 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> S9.51 (SS) - G_VK_I_E - hIgG1 <400> 188 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Lys Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Glu Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 189 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> S9.52 (SS) - R_SS_Q_T - hIgG1 <400> 189 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Arg Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Ser Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Gln Pro Thr Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 190 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> S9.53 (SS) - G_SK_Q_E - hIgG1 <400> 190 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Ser Lys Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Gln Pro Glu Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 191 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> S9.36 (SS) - W38R - hIgG1 NSLF <400> 191 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Arg Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Ser Lys Ala 435 440 445 Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 192 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> S9.37 (SS) - W38Q - hIgG1 NSLF <400> 192 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Gln Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Ser Lys Ala 435 440 445 Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 193 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> S9.38 (SS) - W38K - hIgG1 NSLF <400> 193 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Lys Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Ser Lys Ala 435 440 445 Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 194 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> S9.32 (EC) - W38T <400> 194 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Thr Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 195 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> S9.33 (EC) - W38E <400> 195 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Glu Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 196 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> S9.34 (EC) - W38S <400> 196 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Ser Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 197 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> S9.35 (EC) - W38A <400> 197 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Ala Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 198 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> S9.36 (EC) - W38R <400> 198 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Arg Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 199 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> S9.37 (EC) - W38Q <400> 199 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Gln Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 200 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> S9.38 (EC) - W38K <400> 200 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Lys Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 201 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> S9.39 (EC) - W38S_Y40T <400> 201 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Ser Ile 20 25 30 Thr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 202 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> S9.41 (EC) - L_ER_R <400> 202 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Glu Arg 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Arg Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 203 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> S9.42 (EC) - D_SI_R <400> 203 Ser Lys Asp Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Ser Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Arg Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 204 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> S9.43 (EC) - L_KI_R <400> 204 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Lys Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Arg Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 205 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> S9.44 (EC) - T_EI_E <400> 205 Ser Lys Thr Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Glu Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Glu Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 206 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> S9.45 (EC) - S_QI_R <400> 206 Ser Lys Ser Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Gln Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Arg Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 207 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> S9.47 (EC) - R_SS_I_T <400> 207 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Trp Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Arg Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Ser Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Thr Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 208 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> S9.48 (EC) - R_DS_I_T <400> 208 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Trp Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Arg Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Asp Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Thr Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 209 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> S9.49 (EC) - G_VT_Q_T <400> 209 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Trp Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Thr Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Gln Pro Thr Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 210 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> S9.50 (EC) - N_TT_I_Q <400> 210 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Trp Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Asn Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Thr Thr Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 211 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> S9.51 (EC) - G_VK_I_E <400> 211 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Trp Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Lys Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Glu Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 212 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> S9.52 (EC) - R_SS_Q_T <400> 212 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Trp Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Arg Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Ser Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Gln Pro Thr Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 213 <211> 317 <212> PRT <213> Secuencia Artificial <220> <223> S9.53 (EC) - G_SK_Q_E <400> 213 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Trp Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Ser Lys Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Gln Pro Glu Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 305 310 315 <210> 214 <211> 121 <212> PRT <213> Secuencia Artificial <220> <223> S9.32 (IgV) - W38T <400> 214 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Thr Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr 115 120 <210> 215 <211> 121 <212> PRT <213> Secuencia Artificial <220> <223> S9.33 (IgV) - W38E <400> 215 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Glu Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr 115 120 <210> 216 <211> 121 <212> PRT <213> Secuencia Artificial <220> <223> S9.34 (IgV) - W38S <400> 216 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Ser Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr 115 120 <210> 217 <211> 121 <212> PRT <213> Secuencia Artificial <220> <223> S9.35 (IgV) - W38A <400> 217 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Ala Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr 115 120 <210> 218 <211> 121 <212> PRT <213> Secuencia Artificial <220> <223> S9.36 (IgV) - W38R <400> 218 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Arg Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr 115 120 <210> 219 <211> 121 <212> PRT <213> Secuencia Artificial <220> <223> S9.37 (IgV) - W38Q <400> 219 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Gln Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr 115 120 <210> 220 <211> 121 <212> PRT <213> Secuencia Artificial <220> <223> S9.38 (IgV) - W38K <400> 220 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Lys Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr 115 120 <210> 221 <211> 121 <212> PRT <213> Secuencia Artificial <220> <223> S9.39 (IgV) - W38S_Y40T <400> 221 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Ser Ile 20 25 30 Thr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr 115 120 <210> 222 <211> 121 <212> PRT <213> Secuencia Artificial <220> <223> S9.41 (IgV) - L_ER_R <400> 222 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Glu Arg 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Arg Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr 115 120 <210> 223 <211> 121 <212> PRT <213> Secuencia Artificial <220> <223> S9.42 (IgV) - D_SI_R <400> 223 Ser Lys Asp Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Ser Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Arg Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr 115 120 <210> 224 <211> 121 <212> PRT <213> Secuencia Artificial <220> <223> S9.43 (IgV) - L_KI_R <400> 224 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Lys Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Arg Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr 115 120 <210> 225 <211> 121 <212> PRT <213> Secuencia Artificial <220> <223> S9.44 (IgV) - T_EI_E <400> 225 Ser Lys Thr Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Glu Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Glu Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr 115 120 <210> 226 <211> 121 <212> PRT <213> Secuencia Artificial <220> <223> S9.45 (IgV) - S_QI_R <400> 226 Ser Lys Ser Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Gln Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Arg Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr 115 120 <210> 227 <211> 549 <212> PRT <213> Secuencia Artificial <220> <223> S9.1-hIgG1 NSLF (sin SS) <400> 227 Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln Glu Gly Leu 1 5 10 15 Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His Gly Trp Ile 20 25 30 Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu Gly Ala Asn 35 40 45 Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala Arg Ala Val 50 55 60 Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp Pro His Thr 65 70 75 80 Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser Asp Ala Gly 85 90 95 Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp Asn Tyr Lys 100 105 110 His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His Arg Pro Asn 115 120 125 Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln Asn Leu Thr 130 135 140 Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro Met Ile Ser 145 150 155 160 Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr Thr Arg Ser 165 170 175 Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly Thr Ser Leu 180 185 190 Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr Asn Lys Thr 195 200 205 Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr Met Thr Val 210 215 220 Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn Gly Ser Ser 225 230 235 240 Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys Ala Val Asp 245 250 255 Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser Trp Arg Gly 260 265 270 Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val Leu Glu Leu 275 280 285 Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys Arg Ala Gln 290 295 300 Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser Glu Pro Lys 305 310 315 320 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 325 330 335 Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 340 345 350 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 355 360 365 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 370 375 380 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 385 390 395 400 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 405 410 415 Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Ser Lys Ala Phe Pro Ala 420 425 430 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 435 440 445 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 450 455 460 Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 465 470 475 480 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 485 490 495 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 500 505 510 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 515 520 525 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 530 535 540 Leu Ser Pro Gly Lys 545 <210> 228 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> S9.1-hIgG1 NSLF YTE <400> 228 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Ser Lys Ala 435 440 445 Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 229 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> S9.1-hIgG1 NSLF LS <400> 229 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Ser Lys Ala 435 440 445 Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 230 <211> 580 <212> PRT <213> Secuencia Artificial <220> <223> S9.1-hIgG1 NSLF LV5-112 <400> 230 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Ser Lys Ala 435 440 445 Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gly Cys Ala Leu Tyr Pro 500 505 510 Thr Asn Cys Gly Gly Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 515 520 525 Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 530 535 540 Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 545 550 555 560 Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 565 570 575 Ser Pro Gly Lys 580 <210> 231 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> S9.1-hIgG1 YTE <400> 231 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 232 <211> 568 <212> PRT <213> Secuencia Artificial <220> <223> S9.1-hIgG1 LS <400> 232 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 500 505 510 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 515 520 525 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 530 535 540 Ser Cys Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr Gln Lys 545 550 555 560 Ser Leu Ser Leu Ser Pro Gly Lys 565 <210> 233 <211> 580 <212> PRT <213> Secuencia Artificial <220> <223> S9.1-hIgG1 LV5-112 <400> 233 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 35 40 45 Gly Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 50 55 60 Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 65 70 75 80 Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 85 90 95 Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 100 105 110 Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 115 120 125 Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 130 135 140 Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 145 150 155 160 Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 165 170 175 Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 180 185 190 Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 195 200 205 Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 210 215 220 Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 225 230 235 240 Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 245 250 255 Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 260 265 270 Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 275 280 285 Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 290 295 300 Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 305 310 315 320 Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 325 330 335 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 340 345 350 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 355 360 365 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 370 375 380 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 385 390 395 400 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 405 410 415 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 420 425 430 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 435 440 445 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 450 455 460 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 465 470 475 480 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 485 490 495 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gly Cys Ala Leu Tyr Pro 500 505 510 Thr Asn Cys Gly Gly Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 515 520 525 Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 530 535 540 Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 545 550 555 560 Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 565 570 575 Ser Pro Gly Lys 580 <210> 234 <211> 232 <212> PRT <213> Secuencia Artificial <220> <223> hIgG1 NSLF YTE <400> 234 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 1 5 10 15 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 20 25 30 Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val 35 40 45 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 50 55 60 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 65 70 75 80 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 85 90 95 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Ser Lys Ala 100 105 110 Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 115 120 125 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 130 135 140 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 145 150 155 160 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 165 170 175 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 180 185 190 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 195 200 205 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 210 215 220 Ser Leu Ser Leu Ser Pro Gly Lys 225 230 <210> 235 <211> 232 <212> PRT <213> Secuencia Artificial <220> <223> hIgG1 NSLF LS <400> 235 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 1 5 10 15 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 20 25 30 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 35 40 45 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 50 55 60 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 65 70 75 80 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 85 90 95 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Ser Lys Ala 100 105 110 Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 115 120 125 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 130 135 140 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 145 150 155 160 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 165 170 175 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 180 185 190 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 195 200 205 Ser Cys Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr Gln Lys 210 215 220 Ser Leu Ser Leu Ser Pro Gly Lys 225 230 <210> 236 <211> 244 <212> PRT <213> Secuencia Artificial <220> <223> LV5-112 de NSLF de hIgG1 <400> 236 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 1 5 10 15 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 20 25 30 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 35 40 45 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 50 55 60 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 65 70 75 80 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 85 90 95 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Ser Lys Ala 100 105 110 Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 115 120 125 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 130 135 140 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 145 150 155 160 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gly Cys Ala Leu Tyr Pro 165 170 175 Thr Asn Cys Gly Gly Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 180 185 190 Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 195 200 205 Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 210 215 220 Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 225 230 235 240 Ser Pro Gly Lys <210> 237 <211> 232 <212> PRT <213> Secuencia Artificial <220> <223> hIgG1 YTE <400> 237 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 1 5 10 15 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 20 25 30 Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val 35 40 45 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 50 55 60 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 65 70 75 80 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 85 90 95 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 100 105 110 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 115 120 125 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 130 135 140 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 145 150 155 160 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 165 170 175 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 180 185 190 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 195 200 205 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 210 215 220 Ser Leu Ser Leu Ser Pro Gly Lys 225 230 <210> 238 <211> 232 <212> PRT <213> Secuencia Artificial <220> <223> hIgG1 LS <400> 238 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 1 5 10 15 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 20 25 30 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 35 40 45 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 50 55 60 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 65 70 75 80 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 85 90 95 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 100 105 110 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 115 120 125 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 130 135 140 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 145 150 155 160 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 165 170 175 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 180 185 190 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 195 200 205 Ser Cys Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr Gln Lys 210 215 220 Ser Leu Ser Leu Ser Pro Gly Lys 225 230 <210> 239 <211> 244 <212> PRT <213> Secuencia Artificial <220> <223> hIgG1 LV5-112 <400> 239 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 1 5 10 15 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 20 25 30 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 35 40 45 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 50 55 60 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 65 70 75 80 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 85 90 95 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 100 105 110 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 115 120 125 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 130 135 140 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 145 150 155 160 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gly Cys Ala Leu Tyr Pro 165 170 175 Thr Asn Cys Gly Gly Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 180 185 190 Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 195 200 205 Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 210 215 220 Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 225 230 235 240 Ser Pro Gly Lys