LISTADO DE SECUENCIAS <110> NOVARTIS AG <120> CÉLULA CHO QUE EXPRESA HET IL-15 <130> PAT058680-WO-PCT <140> <141> <150> 62/970.485 <151> 2020-02-05 <160> 29 <170> PatentIn versión 3.5 <210> 1 <211> 162 <212> PRT <213> Homo sapiens <400> 1 Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 1 5 10 15 Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 20 25 30 Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 35 40 45 Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 50 55 60 Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 65 70 75 80 Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 85 90 95 Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 100 105 110 Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 115 120 125 Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 130 135 140 Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 145 150 155 160 Thr Ser <210> 2 <211> 489 <212> ADN <213> Homo sapiens <400> 2 atgagaattt cgaaaccaca tttgagaagt atttccatcc agtgctactt gtgtttactt 60 ctaaacagtc attttctaac tgaagctggc attcatgtct tcattttggg ctgtttcagt 120 gcagggcttc ctaaaacaga agccaactgg gtgaatgtaa taagtgattt gaaaaaaatt 180 gaagatctta ttcaatctat gcatattgat gctactttat atacggaaag tgatgttcac 240 cccagttgca aagtaacagc aatgaagtgc tttctcttgg agttacaagt tatttcactt 300 gagtccggag atgcaagtat tcatgataca gtagaaaatc tgatcatcct agcaaacaac 360 agtttgtctt ctaatgggaa tgtaacagaa tctggatgca aagaatgtga ggaactggag 420 gaaaaaaata ttaaagaatt tttgcagagt tttgtacata ttgtccaaat gttcatcaac 480 acttcttga 489 <210> 3 <211> 396 <212> ADN <213> Homo sapiens <400> 3 atgtggctcc agagcctgct actcctgggg acggtggcct gcagcatctc gaactgggtg 60 aacgtgatct cggacctgaa gaagatcgag gacctcatcc agtcgatgca catcgacgcg 120 acgctgtaca cggagtcgga cgtccacccg tcgtgcaagg tcacggcgat gaagtgcttc 180 ctcctggagc tccaagtcat ctcgctcgag tcgggggacg cgtcgatcca cgacacggtg 240 gagaacctga tcatcctggc gaacaactcg ctgtcgtcga acgggaacgt cacggagtcg 300 ggctgcaagg agtgcgagga gctggaggag aagaacatca aggagttcct gcagtcgttc 360 gtgcacatcg tccagatgtt catcaacacg tcgtga 396 <210> 4 <211> 1847 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido sintético" <400> 4 cctggccatt gcatacgttg tatccatatc ataatatgta catttatatt ggctcatgtc 60 caacattacc gccatgttga cattgattat tgactagtta ttaatagtaa tcaattacgg 120 ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg gtaaatggcc 180 cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg tatgttccca 240 tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta cggtaaactg 300 cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt gacgtcaatg 360 atggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac tttcctactt 420 ggcagtacat ctacgtatta gtcatcgcta ttaccatggt gatgcggttt tggcagtaca 480 tcaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac cccattgacg 540 tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt cgtaacaact 600 ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat ataagcagag 660 ctcgtttagt gaaccgtcag atcgcctgga gacgccatcc acgctgtttt gacctccata 720 gaagacaccg ggaccgatcc agcctccgcg ggcgcgcgtc gacaagaaat gcggatctcg 780 aagccgcacc tgcggtcgat atcgatccag tgctacctgt gcctgctcct gaactcgcac 840 ttcctcacgg aggccggtat acacgtcttc atcctgggct gcttctcggc ggggctgccg 900 aagacggagg cgaactgggt gaacgtgatc tcggacctga agaagatcga ggacctcatc 960 cagtcgatgc acatcgacgc gacgctgtac acggagtcgg acgtccaccc gtcgtgcaag 1020 gtcacggcga tgaagtgctt cctcctggag ctccaagtca tctcgctcga gtcgggggac 1080 gcgtcgatcc acgacacggt ggagaacctg atcatcctgg cgaacaactc gctgtcgtcg 1140 aacgggaacg tcacggagtc gggctgcaag gagtgcgagg agctggagga gaagaacatc 1200 aaggagttcc tgcagtcgtt cgtgcacatc gtccagatgt tcatcaacac gtcgtgaggg 1260 cccggcgcgc cgaattcgcg gatatcggtt aacggatcca gatctgctgt gccttctagt 1320 tgccagccat ctgttgtttg cccctccccc gtgccttcct tgaccctgga aggtgccact 1380 cccactgtcc tttcctaata aaatgaggaa attgcatcgc attgtctgag taggtgtcat 1440 tctattctgg ggggtggggt ggggcaggac agcaaggggg aggattggga agacaatagc 1500 aggcatgctg gggatgcggt gggctctatg ggtacccagg tgctgaagaa ttgacccggt 1560 tcctcctggg ccagaaagaa gcaggcacat ccccttctct gtgacacacc ctgtccacgc 1620 ccctggttct tagttccagc cccactcata ggacactcat agctcaggag ggctccgcct 1680 tcaatcccac ccgctaaagt acttggagcg gtctctccct ccctcatcag cccaccaaac 1740 caaacctagc ctccaagagt gggaagaaat taaagcaaga taggctatta agtgcagagg 1800 gagagaaaat gcctccaaca tgtgaggaag taatgagaga aatcata 1847 <210> 5 <211> 162 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético <400> 5 Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 1 5 10 15 Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 20 25 30 Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 35 40 45 Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 50 55 60 Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 65 70 75 80 Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 85 90 95 Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 100 105 110 Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 115 120 125 Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 130 135 140 Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 145 150 155 160 Thr Ser <210> 6 <211> 267 <212> PRT <213> Homo sapiens <400> 6 Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 1 5 10 15 Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 20 25 30 Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 35 40 45 Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 50 55 60 Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 65 70 75 80 Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 85 90 95 Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 100 105 110 Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 115 120 125 Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 130 135 140 Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 145 150 155 160 Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 165 170 175 Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 180 185 190 Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile 195 200 205 Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 210 215 220 Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu 225 230 235 240 Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg 245 250 255 Asp Glu Asp Leu Glu Asn Cys Ser His His Leu 260 265 <210> 7 <211> 200 <212> PRT <213> Homo sapiens <400> 7 Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 1 5 10 15 Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 20 25 30 Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 35 40 45 Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 50 55 60 Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 65 70 75 80 Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 85 90 95 Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 100 105 110 Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 115 120 125 Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 130 135 140 Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 145 150 155 160 Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 165 170 175 Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 180 185 190 Pro Pro Gly Val Tyr Pro Gln Gly 195 200 <210> 8 <211> 804 <212> ADN <213> Homo sapiens <400> 8 atggccccgc ggcgggcgcg cggctgccgg accctcggtc tcccggcgct gctactgctg 60 ctgctgctcc ggccgccggc gacgcggggc atcacgtgcc ctccccccat gtccgtggaa 120 cacgcagaca tctgggtcaa gagctacagc ttgtactcca gggagcggta catttgtaac 180 tctggtttca agcgtaaagc cggcacgtcc agcctgacgg agtgcgtgtt gaacaaggcc 240 acgaatgtcg cccactggac aacccccagt ctcaaatgca ttagagaccc tgccctggtt 300 caccaaaggc cagcgccacc ctccacagta acgacggcag gggtgacccc acagccagag 360 agcctctccc cttctggaaa agagcccgca gcttcatctc ccagctcaaa caacacagcg 420 gccacaacag cagctattgt cccgggctcc cagctgatgc cttcaaaatc accttccaca 480 ggaaccacag agataagcag tcatgagtcc tcccacggca ccccctctca gacaacagcc 540 aagaactggg aactcacagc atccgcctcc caccagccgc caggtgtgta tccacagggc 600 cacagcgaca ccactgtggc tatctccacg tccactgtcc tgctgtgtgg gctgagcgct 660 gtgtctctcc tggcatgcta cctcaagtca aggcaaactc ccccgctggc cagcgttgaa 720 atggaagcca tggaggctct gccggtgact tgggggacca gcagcagaga tgaagacttg 780 gaaaactgct ctcaccacct atga 804 <210> 9 <211> 600 <212> ADN <213> Homo sapiens <400> 9 atggccccgc ggcgggcgcg cggctgccgg accctcggtc tcccggcgct gctactgctg 60 ctgctgctcc ggccgccggc gacgcggggc atcacgtgcc ctccccccat gtccgtggaa 120 cacgcagaca tctgggtcaa gagctacagc ttgtactcca gggagcggta catttgtaac 180 tctggtttca agcgtaaagc cggcacgtcc agcctgacgg agtgcgtgtt gaacaaggcc 240 acgaatgtcg cccactggac aacccccagt ctcaaatgca ttagagaccc tgccctggtt 300 caccaaaggc cagcgccacc ctccacagta acgacggcag gggtgacccc acagccagag 360 agcctctccc cttctggaaa agagcccgca gcttcatctc ccagctcaaa caacacagcg 420 gccacaacag cagctattgt cccgggctcc cagctgatgc cttcaaaatc accttccaca 480 ggaaccacag agataagcag tcatgagtcc tcccacggca ccccctctca gacaacagcc 540 aagaactggg aactcacagc atccgcctcc caccagccgc caggtgtgta tccacagggc 600 <210> 10 <211> 170 <212> PRT <213> Homo sapiens <400> 10 Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 1 5 10 15 Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 20 25 30 Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 35 40 45 Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 50 55 60 Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val 65 70 75 80 Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly 85 90 95 Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr 100 105 110 Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro 115 120 125 Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr 130 135 140 Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser 145 150 155 160 His Gln Pro Pro Gly Val Tyr Pro Gln Gly 165 170 <210> 11 <211> 2140 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido sintético" <400> 11 cctggccatt gcatacgttg tatccatatc ataatatgta catttatatt ggctcatgtc 60 caacattacc gccatgttga cattgattat tgactagtta ttaatagtaa tcaattacgg 120 ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg gtaaatggcc 180 cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg tatgttccca 240 tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta cggtaaactg 300 cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt gacgtcaatg 360 atggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac tttcctactt 420 ggcagtacat ctacgtatta gtcatcgcta ttaccatggt gatgcggttt tggcagtaca 480 tcaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac cccattgacg 540 tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt cgtaacaact 600 ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat ataagcagag 660 ctcgtttagt gaaccgtcag atcgcctgga gacgccatcc acgctgtttt gacctccata 720 gaagacaccg ggaccgatcc agcctccgcg ggcgcgcgtc gacgctagca agaaatggcc 780 ccgaggcggg cgcgaggctg ccggaccctc ggtctcccgg cgctgctact gctcctgctg 840 ctccggccgc cggcgacgcg gggcatcacg tgcccgcccc ccatgtccgt ggagcacgca 900 gacatctggg tcaagagcta cagcttgtac tcccgggagc ggtacatctg caactcgggt 960 ttcaagcgga aggccggcac gtccagcctg acggagtgcg tgttgaacaa ggccacgaat 1020 gtcgcccact ggacgacccc ctcgctcaag tgcatccgcg acccggccct ggttcaccag 1080 cggcccgcgc caccctccac cgtaacgacg gcgggggtga ccccgcagcc ggagagcctc 1140 tccccgtcgg gaaaggagcc cgccgcgtcg tcgcccagct cgaacaacac ggcggccaca 1200 actgcagcga tcgtcccggg ctcccagctg atgccgtcga agtcgccgtc cacgggaacc 1260 acggagatca gcagtcatga gtcctcccac ggcaccccct cgcaaacgac ggccaagaac 1320 tgggaactca cggcgtccgc ctcccaccag ccgccggggg tgtatccgca aggccacagc 1380 gacaccacgg tggcgatctc cacgtccacg gtcctgctgt gtgggctgag cgcggtgtcg 1440 ctcctggcgt gctacctcaa gtcgaggcag actcccccgc tggccagcgt tgagatggag 1500 gccatggagg ctctgccggt gacgtggggg accagcagca gggatgagga cttggagaac 1560 tgctcgcacc acctataatg agaattcgat ccagatctgc tgtgccttct agttgccagc 1620 catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc actcccactg 1680 tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt cattctattc 1740 tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat agcaggcatg 1800 ctggggatgc ggtgggctct atgggtaccc aggtgctgaa gaattgaccc ggttcctcct 1860 gggccagaaa gaagcaggca catccccttc tctgtgacac accctgtcca cgcccctggt 1920 tcttagttcc agccccactc ataggacact catagctcag gagggctccg ccttcaatcc 1980 cacccgctaa agtacttgga gcggtctctc cctccctcat cagcccacca aaccaaacct 2040 agcctccaag agtgggaaga aattaaagca agataggcta ttaagtgcag agggagagaa 2100 aatgcctcca acatgtgagg aagtaatgag agaaatcata 2140 <210> 12 <211> 267 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 12 Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 1 5 10 15 Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 20 25 30 Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 35 40 45 Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 50 55 60 Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 65 70 75 80 Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 85 90 95 Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 100 105 110 Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 115 120 125 Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 130 135 140 Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 145 150 155 160 Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 165 170 175 Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 180 185 190 Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile 195 200 205 Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 210 215 220 Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu 225 230 235 240 Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg 245 250 255 Asp Glu Asp Leu Glu Asn Cys Ser His His Leu 260 265 <210> 13 <211> 1971 <212> ADN <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polinucleótido sintético" <400> 13 cctggccatt gcatacgttg tatccatatc ataatatgta catttatatt ggctcatgtc 60 caacattacc gccatgttga cattgattat tgactagtta ttaatagtaa tcaattacgg 120 ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg gtaaatggcc 180 cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg tatgttccca 240 tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta cggtaaactg 300 cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt gacgtcaatg 360 atggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac tttcctactt 420 ggcagtacat ctacgtatta gtcatcgcta ttaccatggt gatgcggttt tggcagtaca 480 tcaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac cccattgacg 540 tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt cgtaacaact 600 ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat ataagcagag 660 ctcgtttagt gaaccgtcag atcgcctgga gacgccatcc acgctgtttt gacctccata 720 gaagacaccg ggaccgatcc agcctccgcg ggcgcgcgtc gacgctagca agaaatggcc 780 ccgaggcggg cgcgaggctg ccggaccctc ggtctcccgg cgctgctact gctcctgctg 840 ctccggccgc cggcgacgcg gggcatcacg tgcccgcccc ccatgtccgt ggagcacgca 900 gacatctggg tcaagagcta cagcttgtac tcccgggagc ggtacatctg caactcgggt 960 ttcaagcgga aggccggcac gtccagcctg acggagtgcg tgttgaacaa ggccacgaat 1020 gtcgcccact ggacgacccc ctcgctcaag tgcatccgcg acccggccct ggttcaccag 1080 cggcccgcgc caccctccac cgtaacgacg gcgggggtga ccccgcagcc ggagagcctc 1140 tccccgtcgg gaaaggagcc cgccgcgtcg tcgcccagct cgaacaacac ggcggccaca 1200 actgcagcga tcgtcccggg ctcccagctg atgccgtcga agtcgccgtc cacgggaacc 1260 acggagatca gcagtcatga gtcctcccac ggcaccccct cgcaaacgac ggccaagaac 1320 tgggaactca cggcgtccgc ctcccaccag ccgccggggg tgtatccgca aggccacagc 1380 gacaccacgt aatgagaatt cgcggatatc ggttaacgga tccagatctg ctgtgccttc 1440 tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc tggaaggtgc 1500 cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc tgagtaggtg 1560 tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt gggaagacaa 1620 tagcaggcat gctggggatg cggtgggctc tatgggtacc caggtgctga agaattgacc 1680 cggttcctcc tgggccagaa agaagcaggc acatcccctt ctctgtgaca caccctgtcc 1740 acgcccctgg ttcttagttc cagccccact cataggacac tcatagctca ggagggctcc 1800 gccttcaatc ccacccgcta aagtacttgg agcggtctct ccctccctca tcagcccacc 1860 aaaccaaacc tagcctccaa gagtgggaag aaattaaagc aagataggct attaagtgca 1920 gagggagaga aaatgcctcc aacatgtgag gaagtaatga gagaaatcat a 1971 <210> 14 <211> 205 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 14 Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 1 5 10 15 Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 20 25 30 Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 35 40 45 Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 50 55 60 Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 65 70 75 80 Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 85 90 95 Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 100 105 110 Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 115 120 125 Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 130 135 140 Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 145 150 155 160 Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 165 170 175 Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 180 185 190 Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr 195 200 205 <210> 15 <211> 8 <212> PRT <213> Homo sapiens <400> 15 Pro Gln Gly His Ser Asp Thr Thr 1 5 <210> 16 <211> 7 <212> PRT <213> Homo sapiens <400> 16 Pro Gln Gly His Ser Asp Thr 1 5 <210> 17 <211> 6 <212> PRT <213> Homo sapiens <400> 17 Pro Gln Gly His Ser Asp 1 5 <210> 18 <211> 5 <212> PRT <213> Homo sapiens <400> 18 Pro Gln Gly His Ser 1 5 <210> 19 <211> 4 <212> PRT <213> Homo sapiens <400> 19 Pro Gln Gly His 1 <210> 20 <211> 3 <212> PRT <213> Homo sapiens <400> 20 Pro Gln Gly 1 <210> 21 <211> 175 <212> PRT <213> Homo sapiens <400> 21 Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 1 5 10 15 Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 20 25 30 Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 35 40 45 Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 50 55 60 Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val 65 70 75 80 Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly 85 90 95 Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr 100 105 110 Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro 115 120 125 Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr 130 135 140 Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser 145 150 155 160 His Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr 165 170 175 <210> 22 <211> 19 <212> PRT <213> Homo sapiens <400> 22 Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln Pro Pro Gly Val Tyr 1 5 10 15 Pro Gln Gly <210> 23 <211> 17 <212> PRT <213> Homo sapiens <400> 23 Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 1 5 10 15 Lys <210> 24 <211> 31 <212> PRT <213> Homo sapiens <400> 24 Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 1 5 10 15 Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser 20 25 30 <210> 25 <211> 4 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Péptido sintético" <220> <221> MOD_RES <222> (2)..(3) <223> Cualquier aminoácido <400> 25 Arg Xaa Xaa Arg 1 <210> 26 <211> 6 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Péptido sintético" <220> <221> MOD_RES <222> (1)..(2) <223> Cualquier aminoácido hidrofóbico <220> <221> MOD_RES <222> (5)..(6) <223> Cualquier aminoácido no ácido <400> 26 Xaa Xaa Pro Arg Xaa Xaa 1 5 <210> 27 <211> 436 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 27 Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 1 5 10 15 Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 20 25 30 Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 35 40 45 Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 50 55 60 Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 65 70 75 80 Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 85 90 95 Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 100 105 110 Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 115 120 125 Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 130 135 140 Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 145 150 155 160 Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 165 170 175 Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 180 185 190 Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Pro Lys Ser 195 200 205 Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 210 215 220 Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 225 230 235 240 Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 245 250 255 His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 260 265 270 Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 275 280 285 Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 290 295 300 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 305 310 315 320 Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 325 330 335 Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 340 345 350 Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 355 360 365 Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 370 375 380 Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 385 390 395 400 Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 405 410 415 Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 420 425 430 Ser Pro Gly Lys 435 <210> 28 <211> 431 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 28 Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 1 5 10 15 Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 20 25 30 Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 35 40 45 Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 50 55 60 Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 65 70 75 80 Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 85 90 95 Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 100 105 110 Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 115 120 125 Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 130 135 140 Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 145 150 155 160 Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 165 170 175 Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 180 185 190 Pro Pro Gly Val Tyr Pro Gln Gly Pro Lys Ser Cys Asp Lys Thr His 195 200 205 Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 210 215 220 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 225 230 235 240 Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 245 250 255 Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 260 265 270 Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 275 280 285 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 290 295 300 Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 305 310 315 320 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 325 330 335 Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 340 345 350 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 355 360 365 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 370 375 380 Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 385 390 395 400 Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 405 410 415 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 420 425 430 <210> 29 <211> 159 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 29 Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 1 5 10 15 Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 20 25 30 Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 35 40 45 Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 50 55 60 Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val 65 70 75 80 Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly 85 90 95 Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr 100 105 110 Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro 115 120 125 Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr 130 135 140 Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Ala Asp Ile Gly 145 150 155