LISTADO DE SECUENCIAS <110> TAKEDA PHARMACEUTICAL COMPANY LIMITED <120> COMPOSICIONES Y MÉTODOS DE TERAPIA CELULAR PARA MODULAR LA SEÑALIZACIÓN DEL TGF-B <130> MIL-013WO1 <140> PCT/IB2022/000063 <141> 2022-02-15 <150> 63/306,836 <151> 2022-02-04 <150> 63/149,628 <151> 2021-02-15 <160> 65 <170> PatentIn versión 3.5 <210> 1 <211> 246 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 1 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Asn 20 25 30 Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Val Ile Pro Ile Val Asp Ile Ala Asn Tyr Ala Gln Arg Phe 50 55 60 Lys Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Thr Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Ser Thr Leu Gly Leu Val Leu Asp Ala Met Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr Val Leu Thr Gln Ser 130 135 140 Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 145 150 155 160 Arg Ala Ser Gln Ser Leu Gly Ser Ser Tyr Leu Ala Trp Tyr Gln Gln 165 170 175 Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg 180 185 190 Ala Pro Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 195 200 205 Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr 210 215 220 Tyr Cys Gln Gln Tyr Ala Asp Ser Pro Ile Thr Phe Gly Gln Gly Thr 225 230 235 240 Arg Leu Glu Ile Lys Arg 245 <210> 2 <211> 244 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 2 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Asn 20 25 30 Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Val Ile Pro Ile Val Asp Ile Ala Asn Tyr Ala Gln Arg Phe 50 55 60 Lys Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Thr Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Ser Thr Leu Gly Leu Val Leu Asp Ala Met Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Gly Gly Gly Gly Ser Glu Thr Val Leu Thr Gln Ser Pro Gly 130 135 140 Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 145 150 155 160 Ser Gln Ser Leu Gly Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Pro 180 185 190 Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 195 200 205 Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 210 215 220 Gln Gln Tyr Ala Asp Ser Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu 225 230 235 240 Glu Ile Lys Arg <210> 3 <211> 244 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 3 Glu Thr Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Leu Gly Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Pro Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ala Asp Ser Pro 85 90 95 Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Gly Gly Gly 100 105 110 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 115 120 125 Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val 130 135 140 Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Asn Val Ile Ser Trp 145 150 155 160 Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Val Ile 165 170 175 Pro Ile Val Asp Ile Ala Asn Tyr Ala Gln Arg Phe Lys Gly Arg Val 180 185 190 Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Thr Tyr Met Glu Leu Ser 195 200 205 Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Thr Leu 210 215 220 Gly Leu Val Leu Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 225 230 235 240 Thr Val Ser Ser <210> 4 <211> 243 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 4 Gln Leu Gln Val Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asn Ser 20 25 30 Tyr Phe Ser Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Ser Phe Tyr Tyr Gly Glu Lys Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Ala Thr Ile Ser Ile Asp Thr Ser Lys Ser Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Pro Arg Gly Pro Thr Met Ile Arg Gly Val Ile Asp Ser Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro 130 135 140 Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 145 150 155 160 Ala Ser Gln Ser Val Arg Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr 180 185 190 Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 210 215 220 Gln Gln Arg Ser Asn Trp Pro Pro Thr Phe Gly Gln Gly Thr Lys Val 225 230 235 240 Glu Ile Lys <210> 5 <211> 243 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 5 Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 100 105 110 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Leu Gln Val Gln Glu 115 120 125 Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys 130 135 140 Thr Val Ser Gly Gly Ser Ile Ser Asn Ser Tyr Phe Ser Trp Gly Trp 145 150 155 160 Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Ser Phe Tyr 165 170 175 Tyr Gly Glu Lys Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Ala Thr 180 185 190 Ile Ser Ile Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys Leu Ser Ser 195 200 205 Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Pro Arg Gly Pro Thr 210 215 220 Met Ile Arg Gly Val Ile Asp Ser Trp Gly Gln Gly Thr Leu Val Thr 225 230 235 240 Val Ser Ser <210> 6 <211> 122 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 6 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Thr Tyr 20 25 30 Gly Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Trp Ile Glu Lys Thr Gly Asn Lys Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ala Arg His Ile Lys Val Arg Ser Arg Asp Phe Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 7 <211> 123 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 7 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Thr Tyr 20 25 30 Gly Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Trp Ile Glu Lys Thr Gly Asn Lys Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ala Gly Arg His Ile Lys Val Arg Ser Arg Asp Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 8 <211> 122 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 8 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Thr Glu 20 25 30 Gln Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 35 40 45 Ser Arg Ile Asp Ser Pro Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Arg Arg Pro Thr Gly Val Ser Gly Thr Phe Tyr Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 9 <211> 249 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 9 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Thr Glu 20 25 30 Gln Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 35 40 45 Ser Arg Ile Asp Ser Pro Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Arg Arg Pro Thr Gly Val Ser Gly Thr Phe Tyr Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu 115 120 125 Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 130 135 140 Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Thr Glu Gln 145 150 155 160 Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val Ser 165 170 175 Arg Ile Asp Ser Pro Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys 180 185 190 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 195 200 205 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 210 215 220 Lys Arg Arg Pro Thr Gly Val Ser Gly Thr Phe Tyr Asp Tyr Trp Gly 225 230 235 240 Gln Gly Thr Leu Val Thr Val Ser Ser 245 <210> 10 <211> 254 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 10 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Thr Glu 20 25 30 Gln Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 35 40 45 Ser Arg Ile Asp Ser Pro Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Arg Arg Pro Thr Gly Val Ser Gly Thr Phe Tyr Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 115 120 125 Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val 130 135 140 Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 145 150 155 160 Phe Gly Thr Glu Gln Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly 165 170 175 Leu Glu Phe Val Ser Arg Ile Asp Ser Pro Gly Gly Arg Thr Tyr Tyr 180 185 190 Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 195 200 205 Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 210 215 220 Val Tyr Tyr Cys Ala Lys Arg Arg Pro Thr Gly Val Ser Gly Thr Phe 225 230 235 240 Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 245 250 <210> 11 <211> 255 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 11 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Thr Glu 20 25 30 Gln Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 35 40 45 Ser Arg Ile Asp Ser Pro Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Arg Arg Pro Thr Gly Val Ser Gly Thr Phe Tyr Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Ser Glu Pro Lys 115 120 125 Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Gly Gly Gly Ser Ser 130 135 140 Gly Gly Gly Ser Gly Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 145 150 155 160 Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 165 170 175 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 180 185 190 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 195 200 205 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 210 215 220 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 225 230 235 240 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 245 250 255 <210> 12 <211> 385 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 12 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Thr Glu 20 25 30 Gln Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 35 40 45 Ser Arg Ile Asp Ser Pro Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Arg Arg Pro Thr Gly Val Ser Gly Thr Phe Tyr Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Ser Glu Pro Lys 115 120 125 Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Gly Gly Gly Ser Ser 130 135 140 Gly Gly Gly Ser Gly Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 145 150 155 160 Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 165 170 175 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 180 185 190 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 195 200 205 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 210 215 220 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 225 230 235 240 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly 245 250 255 Gly Gly Gly Ser Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly 260 265 270 Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 275 280 285 Gly Phe Thr Phe Gly Thr Glu Gln Met Trp Trp Val Arg Gln Ala Pro 290 295 300 Gly Lys Gly Leu Glu Phe Val Ser Arg Ile Asp Ser Pro Gly Gly Arg 305 310 315 320 Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 325 330 335 Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 340 345 350 Asp Thr Ala Val Tyr Tyr Cys Ala Lys Arg Arg Pro Thr Gly Val Ser 355 360 365 Gly Thr Phe Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 370 375 380 Ser 385 <210> 13 <211> 238 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 13 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Thr Glu 20 25 30 Gln Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 35 40 45 Ser Arg Ile Asp Ser Pro Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Arg Arg Pro Thr Gly Val Ser Gly Thr Phe Tyr Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Ser Gly 115 120 125 Gly Gly Ser Gly Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 130 135 140 Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 145 150 155 160 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 165 170 175 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 180 185 190 Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 195 200 205 Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 210 215 220 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 225 230 235 <210> 14 <211> 368 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 14 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Thr Glu 20 25 30 Gln Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 35 40 45 Ser Arg Ile Asp Ser Pro Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Arg Arg Pro Thr Gly Val Ser Gly Thr Phe Tyr Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Ser Gly 115 120 125 Gly Gly Ser Gly Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 130 135 140 Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 145 150 155 160 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 165 170 175 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 180 185 190 Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 195 200 205 Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 210 215 220 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly 225 230 235 240 Gly Gly Ser Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 245 250 255 Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 260 265 270 Phe Thr Phe Gly Thr Glu Gln Met Trp Trp Val Arg Gln Ala Pro Gly 275 280 285 Lys Gly Leu Glu Phe Val Ser Arg Ile Asp Ser Pro Gly Gly Arg Thr 290 295 300 Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 305 310 315 320 Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 325 330 335 Thr Ala Val Tyr Tyr Cys Ala Lys Arg Arg Pro Thr Gly Val Ser Gly 340 345 350 Thr Phe Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 355 360 365 <210> 15 <211> 376 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 15 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Thr Glu 20 25 30 Gln Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 35 40 45 Ser Arg Ile Asp Ser Pro Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Arg Arg Pro Thr Gly Val Ser Gly Thr Phe Tyr Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu 115 120 125 Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 130 135 140 Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Thr Glu Gln 145 150 155 160 Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val Ser 165 170 175 Arg Ile Asp Ser Pro Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys 180 185 190 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 195 200 205 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 210 215 220 Lys Arg Arg Pro Thr Gly Val Ser Gly Thr Phe Tyr Asp Tyr Trp Gly 225 230 235 240 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Val 245 250 255 Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 260 265 270 Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Thr Glu Gln Met 275 280 285 Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val Ser Arg 290 295 300 Ile Asp Ser Pro Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly 305 310 315 320 Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 325 330 335 Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 340 345 350 Arg Arg Pro Thr Gly Val Ser Gly Thr Phe Tyr Asp Tyr Trp Gly Gln 355 360 365 Gly Thr Leu Val Thr Val Ser Ser 370 375 <210> 16 <211> 762 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 16 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Thr Glu 20 25 30 Gln Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 35 40 45 Ser Arg Ile Asp Ser Pro Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Arg Arg Pro Thr Gly Val Ser Gly Thr Phe Tyr Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu 115 120 125 Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 130 135 140 Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Thr Glu Gln 145 150 155 160 Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val Ser 165 170 175 Arg Ile Asp Ser Pro Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys 180 185 190 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 195 200 205 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 210 215 220 Lys Arg Arg Pro Thr Gly Val Ser Gly Thr Phe Tyr Asp Tyr Trp Gly 225 230 235 240 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Val 245 250 255 Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 260 265 270 Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Thr Glu Gln Met 275 280 285 Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val Ser Arg 290 295 300 Ile Asp Ser Pro Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly 305 310 315 320 Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 325 330 335 Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 340 345 350 Arg Arg Pro Thr Gly Val Ser Gly Thr Phe Tyr Asp Tyr Trp Gly Gln 355 360 365 Gly Thr Leu Val Thr Val Ser Ser Glu Val Gln Leu Leu Glu Ser Gly 370 375 380 Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 385 390 395 400 Ser Gly Phe Thr Phe Gly Thr Glu Gln Met Trp Trp Val Arg Gln Ala 405 410 415 Pro Gly Lys Gly Leu Glu Phe Val Ser Arg Ile Asp Ser Pro Gly Gly 420 425 430 Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 435 440 445 Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 450 455 460 Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Arg Arg Pro Thr Gly Val 465 470 475 480 Ser Gly Thr Phe Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 485 490 495 Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 500 505 510 Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 515 520 525 Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Thr Glu Gln Met Trp Trp 530 535 540 Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val Ser Arg Ile Asp 545 550 555 560 Ser Pro Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 565 570 575 Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn 580 585 590 Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Arg Arg 595 600 605 Pro Thr Gly Val Ser Gly Thr Phe Tyr Asp Tyr Trp Gly Gln Gly Thr 610 615 620 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 625 630 635 640 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 645 650 655 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Thr Glu 660 665 670 Gln Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 675 680 685 Ser Arg Ile Asp Ser Pro Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val 690 695 700 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 705 710 715 720 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 725 730 735 Ala Lys Arg Arg Pro Thr Gly Val Ser Gly Thr Phe Tyr Asp Tyr Trp 740 745 750 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 755 760 <210> 17 <211> 495 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 17 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Asn 20 25 30 Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Val Ile Pro Ile Val Asp Ile Ala Asn Tyr Ala Gln Arg Phe 50 55 60 Lys Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Thr Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Ser Thr Leu Gly Leu Val Leu Asp Ala Met Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr Val Leu Thr Gln Ser 130 135 140 Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 145 150 155 160 Arg Ala Ser Gln Ser Leu Gly Ser Ser Tyr Leu Ala Trp Tyr Gln Gln 165 170 175 Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg 180 185 190 Ala Pro Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 195 200 205 Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr 210 215 220 Tyr Cys Gln Gln Tyr Ala Asp Ser Pro Ile Thr Phe Gly Gln Gly Thr 225 230 235 240 Arg Leu Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln 245 250 255 Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys 260 265 270 Lys Ala Ser Gly Tyr Thr Phe Ser Ser Asn Val Ile Ser Trp Val Arg 275 280 285 Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Val Ile Pro Ile 290 295 300 Val Asp Ile Ala Asn Tyr Ala Gln Arg Phe Lys Gly Arg Val Thr Ile 305 310 315 320 Thr Ala Asp Glu Ser Thr Ser Thr Thr Tyr Met Glu Leu Ser Ser Leu 325 330 335 Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Thr Leu Gly Leu 340 345 350 Val Leu Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 355 360 365 Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 370 375 380 Ser Ala Leu Glu Thr Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu 385 390 395 400 Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Leu 405 410 415 Gly Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 420 425 430 Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Pro Gly Ile Pro Asp 435 440 445 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 450 455 460 Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ala 465 470 475 480 Asp Ser Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 485 490 495 <210> 18 <211> 500 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 18 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Asn 20 25 30 Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Val Ile Pro Ile Val Asp Ile Ala Asn Tyr Ala Gln Arg Phe 50 55 60 Lys Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Thr Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Ser Thr Leu Gly Leu Val Leu Asp Ala Met Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr Val Leu Thr Gln Ser 130 135 140 Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 145 150 155 160 Arg Ala Ser Gln Ser Leu Gly Ser Ser Tyr Leu Ala Trp Tyr Gln Gln 165 170 175 Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg 180 185 190 Ala Pro Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 195 200 205 Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr 210 215 220 Tyr Cys Gln Gln Tyr Ala Asp Ser Pro Ile Thr Phe Gly Gln Gly Thr 225 230 235 240 Arg Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 245 250 255 Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser 260 265 270 Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Asn Val 275 280 285 Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 290 295 300 Gly Val Ile Pro Ile Val Asp Ile Ala Asn Tyr Ala Gln Arg Phe Lys 305 310 315 320 Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Thr Tyr Met 325 330 335 Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 340 345 350 Ser Thr Leu Gly Leu Val Leu Asp Ala Met Asp Tyr Trp Gly Gln Gly 355 360 365 Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 370 375 380 Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr Val Leu Thr Gln Ser Pro 385 390 395 400 Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 405 410 415 Ala Ser Gln Ser Leu Gly Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys 420 425 430 Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala 435 440 445 Pro Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 450 455 460 Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr 465 470 475 480 Cys Gln Gln Tyr Ala Asp Ser Pro Ile Thr Phe Gly Gln Gly Thr Arg 485 490 495 Leu Glu Ile Lys 500 <210> 19 <211> 378 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 19 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Asn 20 25 30 Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Val Ile Pro Ile Val Asp Ile Ala Asn Tyr Ala Gln Arg Phe 50 55 60 Lys Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Thr Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Ser Thr Leu Gly Leu Val Leu Asp Ala Met Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr Val Leu Thr Gln Ser 130 135 140 Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 145 150 155 160 Arg Ala Ser Gln Ser Leu Gly Ser Ser Tyr Leu Ala Trp Tyr Gln Gln 165 170 175 Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg 180 185 190 Ala Pro Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 195 200 205 Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr 210 215 220 Tyr Cys Gln Gln Tyr Ala Asp Ser Pro Ile Thr Phe Gly Gln Gly Thr 225 230 235 240 Arg Leu Glu Ile Lys Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr 245 250 255 His Thr Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly 260 265 270 Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 275 280 285 Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 290 295 300 Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 305 310 315 320 Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 325 330 335 Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 340 345 350 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 355 360 365 Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 370 375 <210> 20 <211> 631 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 20 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Asn 20 25 30 Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Val Ile Pro Ile Val Asp Ile Ala Asn Tyr Ala Gln Arg Phe 50 55 60 Lys Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Thr Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Ser Thr Leu Gly Leu Val Leu Asp Ala Met Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr Val Leu Thr Gln Ser 130 135 140 Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 145 150 155 160 Arg Ala Ser Gln Ser Leu Gly Ser Ser Tyr Leu Ala Trp Tyr Gln Gln 165 170 175 Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg 180 185 190 Ala Pro Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 195 200 205 Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr 210 215 220 Tyr Cys Gln Gln Tyr Ala Asp Ser Pro Ile Thr Phe Gly Gln Gly Thr 225 230 235 240 Arg Leu Glu Ile Lys Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr 245 250 255 His Thr Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly 260 265 270 Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 275 280 285 Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 290 295 300 Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 305 310 315 320 Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 325 330 335 Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 340 345 350 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 355 360 365 Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly 370 375 380 Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 385 390 395 400 Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser 405 410 415 Ser Asn Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 420 425 430 Trp Met Gly Gly Val Ile Pro Ile Val Asp Ile Ala Asn Tyr Ala Gln 435 440 445 Arg Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr 450 455 460 Thr Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr 465 470 475 480 Tyr Cys Ala Ser Thr Leu Gly Leu Val Leu Asp Ala Met Asp Tyr Trp 485 490 495 Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 500 505 510 Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr Val Leu Thr 515 520 525 Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 530 535 540 Ser Cys Arg Ala Ser Gln Ser Leu Gly Ser Ser Tyr Leu Ala Trp Tyr 545 550 555 560 Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser 565 570 575 Ser Arg Ala Pro Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 580 585 590 Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala 595 600 605 Val Tyr Tyr Cys Gln Gln Tyr Ala Asp Ser Pro Ile Thr Phe Gly Gln 610 615 620 Gly Thr Arg Leu Glu Ile Lys 625 630 <210> 21 <211> 361 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 21 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Asn 20 25 30 Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Val Ile Pro Ile Val Asp Ile Ala Asn Tyr Ala Gln Arg Phe 50 55 60 Lys Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Thr Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Ser Thr Leu Gly Leu Val Leu Asp Ala Met Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr Val Leu Thr Gln Ser 130 135 140 Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 145 150 155 160 Arg Ala Ser Gln Ser Leu Gly Ser Ser Tyr Leu Ala Trp Tyr Gln Gln 165 170 175 Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg 180 185 190 Ala Pro Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 195 200 205 Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr 210 215 220 Tyr Cys Gln Gln Tyr Ala Asp Ser Pro Ile Thr Phe Gly Gln Gly Thr 225 230 235 240 Arg Leu Glu Ile Lys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly 245 250 255 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 260 265 270 Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 275 280 285 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 290 295 300 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 305 310 315 320 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 325 330 335 Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 340 345 350 Gln Lys Ser Leu Ser Leu Ser Pro Gly 355 360 <210> 22 <211> 614 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 22 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Asn 20 25 30 Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Val Ile Pro Ile Val Asp Ile Ala Asn Tyr Ala Gln Arg Phe 50 55 60 Lys Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Thr Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Ser Thr Leu Gly Leu Val Leu Asp Ala Met Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr Val Leu Thr Gln Ser 130 135 140 Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 145 150 155 160 Arg Ala Ser Gln Ser Leu Gly Ser Ser Tyr Leu Ala Trp Tyr Gln Gln 165 170 175 Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg 180 185 190 Ala Pro Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 195 200 205 Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr 210 215 220 Tyr Cys Gln Gln Tyr Ala Asp Ser Pro Ile Thr Phe Gly Gln Gly Thr 225 230 235 240 Arg Leu Glu Ile Lys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly 245 250 255 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 260 265 270 Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 275 280 285 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 290 295 300 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 305 310 315 320 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 325 330 335 Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 340 345 350 Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly 355 360 365 Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 370 375 380 Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser 385 390 395 400 Asn Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 405 410 415 Met Gly Gly Val Ile Pro Ile Val Asp Ile Ala Asn Tyr Ala Gln Arg 420 425 430 Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Thr 435 440 445 Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr 450 455 460 Cys Ala Ser Thr Leu Gly Leu Val Leu Asp Ala Met Asp Tyr Trp Gly 465 470 475 480 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 485 490 495 Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr Val Leu Thr Gln 500 505 510 Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 515 520 525 Cys Arg Ala Ser Gln Ser Leu Gly Ser Ser Tyr Leu Ala Trp Tyr Gln 530 535 540 Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser 545 550 555 560 Arg Ala Pro Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 565 570 575 Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val 580 585 590 Tyr Tyr Cys Gln Gln Tyr Ala Asp Ser Pro Ile Thr Phe Gly Gln Gly 595 600 605 Thr Arg Leu Glu Ile Lys 610 <210> 23 <211> 491 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 23 Gln Leu Gln Val Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asn Ser 20 25 30 Tyr Phe Ser Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Ser Phe Tyr Tyr Gly Glu Lys Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Ala Thr Ile Ser Ile Asp Thr Ser Lys Ser Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Pro Arg Gly Pro Thr Met Ile Arg Gly Val Ile Asp Ser Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro 130 135 140 Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 145 150 155 160 Ala Ser Gln Ser Val Arg Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr 180 185 190 Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 210 215 220 Gln Gln Arg Ser Asn Trp Pro Pro Thr Phe Gly Gln Gly Thr Lys Val 225 230 235 240 Glu Ile Lys Gly Gly Gly Gly Ser Gln Leu Gln Val Gln Glu Ser Gly 245 250 255 Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val 260 265 270 Ser Gly Gly Ser Ile Ser Asn Ser Tyr Phe Ser Trp Gly Trp Ile Arg 275 280 285 Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Ser Phe Tyr Tyr Gly 290 295 300 Glu Lys Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Ala Thr Ile Ser 305 310 315 320 Ile Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys Leu Ser Ser Val Thr 325 330 335 Ala Ala Asp Thr Ala Val Tyr Tyr Cys Pro Arg Gly Pro Thr Met Ile 340 345 350 Arg Gly Val Ile Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser 355 360 365 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 385 390 395 400 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Tyr 405 410 415 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 420 425 430 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 435 440 445 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 450 455 460 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 465 470 475 480 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 485 490 <210> 24 <211> 496 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 24 Gln Leu Gln Val Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asn Ser 20 25 30 Tyr Phe Ser Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Ser Phe Tyr Tyr Gly Glu Lys Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Ala Thr Ile Ser Ile Asp Thr Ser Lys Ser Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Pro Arg Gly Pro Thr Met Ile Arg Gly Val Ile Asp Ser Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro 130 135 140 Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 145 150 155 160 Ala Ser Gln Ser Val Arg Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr 180 185 190 Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 210 215 220 Gln Gln Arg Ser Asn Trp Pro Pro Thr Phe Gly Gln Gly Thr Lys Val 225 230 235 240 Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Leu Gln 245 250 255 Val Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser 260 265 270 Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asn Ser Tyr Phe Ser 275 280 285 Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 290 295 300 Ser Phe Tyr Tyr Gly Glu Lys Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 305 310 315 320 Arg Ala Thr Ile Ser Ile Asp Thr Ser Lys Ser Gln Phe Ser Leu Lys 325 330 335 Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Pro Arg 340 345 350 Gly Pro Thr Met Ile Arg Gly Val Ile Asp Ser Trp Gly Gln Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 385 390 395 400 Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln 405 410 415 Ser Val Arg Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 420 425 430 Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro 435 440 445 Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 450 455 460 Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg 465 470 475 480 Ser Asn Trp Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 485 490 495 <210> 25 <211> 376 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 25 Gln Leu Gln Val Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asn Ser 20 25 30 Tyr Phe Ser Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Ser Phe Tyr Tyr Gly Glu Lys Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Ala Thr Ile Ser Ile Asp Thr Ser Lys Ser Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Pro Arg Gly Pro Thr Met Ile Arg Gly Val Ile Asp Ser Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro 130 135 140 Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 145 150 155 160 Ala Ser Gln Ser Val Arg Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr 180 185 190 Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 210 215 220 Gln Gln Arg Ser Asn Trp Pro Pro Thr Phe Gly Gln Gly Thr Lys Val 225 230 235 240 Glu Ile Lys Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr 245 250 255 Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly Gln 260 265 270 Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 275 280 285 Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 290 295 300 Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 305 310 315 320 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 325 330 335 Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 340 345 350 Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 355 360 365 Lys Ser Leu Ser Leu Ser Pro Gly 370 375 <210> 26 <211> 627 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 26 Gln Leu Gln Val Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asn Ser 20 25 30 Tyr Phe Ser Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Ser Phe Tyr Tyr Gly Glu Lys Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Ala Thr Ile Ser Ile Asp Thr Ser Lys Ser Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Pro Arg Gly Pro Thr Met Ile Arg Gly Val Ile Asp Ser Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro 130 135 140 Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 145 150 155 160 Ala Ser Gln Ser Val Arg Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr 180 185 190 Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 210 215 220 Gln Gln Arg Ser Asn Trp Pro Pro Thr Phe Gly Gln Gly Thr Lys Val 225 230 235 240 Glu Ile Lys Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr 245 250 255 Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly Gln 260 265 270 Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 275 280 285 Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 290 295 300 Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 305 310 315 320 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 325 330 335 Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 340 345 350 Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 355 360 365 Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Ser 370 375 380 Gln Leu Gln Val Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 385 390 395 400 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asn Ser 405 410 415 Tyr Phe Ser Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 420 425 430 Trp Ile Gly Ser Phe Tyr Tyr Gly Glu Lys Thr Tyr Tyr Asn Pro Ser 435 440 445 Leu Lys Ser Arg Ala Thr Ile Ser Ile Asp Thr Ser Lys Ser Gln Phe 450 455 460 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 465 470 475 480 Cys Pro Arg Gly Pro Thr Met Ile Arg Gly Val Ile Asp Ser Trp Gly 485 490 495 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 500 505 510 Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro 515 520 525 Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 530 535 540 Ala Ser Gln Ser Val Arg Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 545 550 555 560 Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr 565 570 575 Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 580 585 590 Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 595 600 605 Gln Gln Arg Ser Asn Trp Pro Pro Thr Phe Gly Gln Gly Thr Lys Val 610 615 620 Glu Ile Lys 625 <210> 27 <211> 359 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 27 Gln Leu Gln Val Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asn Ser 20 25 30 Tyr Phe Ser Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Ser Phe Tyr Tyr Gly Glu Lys Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Ala Thr Ile Ser Ile Asp Thr Ser Lys Ser Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Pro Arg Gly Pro Thr Met Ile Arg Gly Val Ile Asp Ser Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro 130 135 140 Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 145 150 155 160 Ala Ser Gln Ser Val Arg Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr 180 185 190 Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 210 215 220 Gln Gln Arg Ser Asn Trp Pro Pro Thr Phe Gly Gln Gly Thr Lys Val 225 230 235 240 Glu Ile Lys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly Gln Pro 245 250 255 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 260 265 270 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 275 280 285 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 290 295 300 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 305 310 315 320 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 325 330 335 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 340 345 350 Ser Leu Ser Leu Ser Pro Gly 355 <210> 28 <211> 610 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 28 Gln Leu Gln Val Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asn Ser 20 25 30 Tyr Phe Ser Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Ser Phe Tyr Tyr Gly Glu Lys Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Ala Thr Ile Ser Ile Asp Thr Ser Lys Ser Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Pro Arg Gly Pro Thr Met Ile Arg Gly Val Ile Asp Ser Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro 130 135 140 Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 145 150 155 160 Ala Ser Gln Ser Val Arg Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr 180 185 190 Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 210 215 220 Gln Gln Arg Ser Asn Trp Pro Pro Thr Phe Gly Gln Gly Thr Lys Val 225 230 235 240 Glu Ile Lys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly Gln Pro 245 250 255 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 260 265 270 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 275 280 285 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 290 295 300 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 305 310 315 320 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 325 330 335 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 340 345 350 Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Ser Gln 355 360 365 Leu Gln Val Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 370 375 380 Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asn Ser Tyr 385 390 395 400 Phe Ser Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 405 410 415 Ile Gly Ser Phe Tyr Tyr Gly Glu Lys Thr Tyr Tyr Asn Pro Ser Leu 420 425 430 Lys Ser Arg Ala Thr Ile Ser Ile Asp Thr Ser Lys Ser Gln Phe Ser 435 440 445 Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 450 455 460 Pro Arg Gly Pro Thr Met Ile Arg Gly Val Ile Asp Ser Trp Gly Gln 465 470 475 480 Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 485 490 495 Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala 500 505 510 Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 515 520 525 Ser Gln Ser Val Arg Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 530 535 540 Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly 545 550 555 560 Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 565 570 575 Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln 580 585 590 Gln Arg Ser Asn Trp Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu 595 600 605 Ile Lys 610 <210> 29 <211> 120 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 29 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Gln Glu 20 25 30 Ser Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ser Gly Thr Arg Ile Lys Gln Gly Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 30 <211> 124 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 30 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Thr Glu Tyr 20 25 30 Arg Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Glu Pro Ile Gly His Arg Thr Tyr Tyr Ala Asn Ser Val 50 55 60 Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gln Ala Pro Gly Glu Lys Trp Ala Arg Arg Trp Asp Leu Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 31 <211> 122 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 31 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Thr Asp 20 25 30 Gln Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 35 40 45 Ser Arg Ile Asp Ser Pro Gly Gly Arg Thr Tyr Tyr Ala Asn Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Arg Gln Pro Ala Gly Val Ser Gly Lys Tyr Val Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 32 <211> 162 <212> PRT <213> Mus sp. <400> 32 Ile Pro Pro His Val Pro Lys Ser Asp Val Glu Met Glu Ala Gln Lys 1 5 10 15 Asp Ala Ser Ile His Leu Ser Cys Asn Arg Thr Ile His Pro Leu Lys 20 25 30 His Phe Asn Ser Asp Val Met Ala Ser Asp Asn Gly Gly Ala Val Lys 35 40 45 Leu Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Leu Ser Thr Cys Asp 50 55 60 Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ala Ile Cys Glu 65 70 75 80 Lys Pro His Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Lys Asn 85 90 95 Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Thr Tyr His Gly 100 105 110 Phe Thr Leu Glu Asp Ala Ala Ser Pro Lys Cys Val Met Lys Glu Lys 115 120 125 Lys Arg Ala Gly Glu Thr Phe Phe Met Cys Ala Cys Asn Met Glu Glu 130 135 140 Cys Asn Asp Tyr Ile Ile Phe Ser Glu Glu Tyr Thr Thr Ser Ser Pro 145 150 155 160 Asp Leu <210> 33 <211> 234 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 33 Leu Gln Cys Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr Cys Val 1 5 10 15 Thr Asp Gly Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp Lys Val 20 25 30 Ile His Asn Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro Arg Asp 35 40 45 Arg Pro Phe Val Cys Ala Pro Ser Ser Lys Thr Gly Ser Val Thr Thr 50 55 60 Thr Tyr Cys Cys Asn Gln Asp His Cys Asn Lys Ile Glu Leu Pro Thr 65 70 75 80 Thr Val Lys Ser Ser Pro Gly Leu Gly Pro Val Glu Gly Gly Gly Gly 85 90 95 Ser Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile 100 105 110 Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe 115 120 125 Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser 130 135 140 Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val 145 150 155 160 Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys 165 170 175 His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala 180 185 190 Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe 195 200 205 Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe 210 215 220 Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp 225 230 <210> 34 <211> 186 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 34 Gln Cys Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr Cys Val Thr 1 5 10 15 Asp Gly Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp Lys Val Ile 20 25 30 His Asn Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro Arg Asp Arg 35 40 45 Pro Phe Val Cys Ala Pro Ser Ser Lys Thr Gly Ser Val Thr Thr Thr 50 55 60 Tyr Cys Cys Asn Gln Asp His Cys Asn Gly Gly Gly Gly Ser Ala Val 65 70 75 80 Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys 85 90 95 Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys 100 105 110 Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu 115 120 125 Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His 130 135 140 Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu 145 150 155 160 Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp 165 170 175 Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 180 185 <210> 35 <211> 238 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 35 Leu Gln Cys Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr Cys Glu 1 5 10 15 Thr Asp Gly Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp Lys Val 20 25 30 Ile His Asn Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro Arg Asp 35 40 45 Arg Pro Phe Val Cys Ala Pro Ser Ser Lys Thr Gly Ala Val Thr Thr 50 55 60 Thr Tyr Cys Cys Asn Gln Asp His Cys Asn Lys Ile Glu Leu Pro Thr 65 70 75 80 Thr Gly Pro Phe Ser Glu Lys Gln Ser Ala Gly Leu Gly Pro Val Glu 85 90 95 Leu Gly Gly Gly Gly Ser Ile Pro Pro His Val Pro Lys Ser Val Asn 100 105 110 Ser Asp Val Met Ala Ser Asp Asn Gly Gly Ala Val Lys Leu Pro Gln 115 120 125 Leu Cys Lys Phe Cys Asp Val Arg Leu Ser Thr Cys Asp Asn Gln Lys 130 135 140 Ser Cys Met Ser Asn Cys Ser Ile Thr Ala Ile Cys Glu Lys Pro His 145 150 155 160 Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Lys Asn Ile Thr Leu 165 170 175 Glu Thr Val Cys His Asp Pro Lys Leu Thr Tyr His Gly Phe Thr Leu 180 185 190 Glu Asp Ala Ala Ser Pro Lys Cys Val Met Lys Glu Lys Lys Arg Ala 195 200 205 Gly Glu Thr Phe Phe Met Cys Ala Cys Asn Met Glu Glu Cys Asn Asp 210 215 220 Tyr Ile Ile Phe Ser Glu Glu Tyr Thr Thr Ser Ser Pro Asp 225 230 235 <210> 36 <211> 160 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 36 Gln Cys Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr Cys Glu Thr 1 5 10 15 Asp Gly Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp Lys Val Ile 20 25 30 His Asn Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro Arg Asp Arg 35 40 45 Pro Phe Val Cys Ala Pro Ser Ser Lys Thr Gly Ala Val Thr Thr Thr 50 55 60 Tyr Cys Cys Asn Gln Asp His Cys Asn Gly Gly Gly Gly Ser Ala Val 65 70 75 80 Lys Leu Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Leu Ser Thr Cys 85 90 95 Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ala Ile Cys 100 105 110 Glu Lys Pro His Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Lys 115 120 125 Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Thr Tyr His 130 135 140 Gly Phe Thr Leu Glu Asp Ala Ala Ser Pro Lys Cys Val Met Lys Glu 145 150 155 160 <210> 37 <211> 182 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 37 Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 1 5 10 15 Gly Ser Thr Gly Ile Pro Pro His Val Pro Lys Ser Asp Val Glu Met 20 25 30 Glu Ala Gln Lys Asp Ala Ser Ile His Leu Ser Cys Asn Arg Thr Ile 35 40 45 His Pro Leu Lys His Phe Asn Ser Asp Val Met Ala Ser Asp Asn Gly 50 55 60 Gly Ala Val Lys Leu Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Leu 65 70 75 80 Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr 85 90 95 Ala Ile Cys Glu Lys Pro His Glu Val Cys Val Ala Val Trp Arg Lys 100 105 110 Asn Asp Lys Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu 115 120 125 Thr Tyr His Gly Phe Thr Leu Glu Asp Ala Ala Ser Pro Lys Cys Val 130 135 140 Met Lys Glu Lys Lys Arg Ala Gly Glu Thr Phe Phe Met Cys Ala Cys 145 150 155 160 Asn Met Glu Glu Cys Asn Asp Tyr Ile Ile Phe Ser Glu Glu Tyr Thr 165 170 175 Thr Ser Ser Pro Asp Leu 180 <210> 38 <211> 397 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 38 Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 1 5 10 15 Gly Ser Thr Gly Ile Pro Pro His Val Pro Lys Ser Asp Val Glu Met 20 25 30 Glu Ala Gln Lys Asp Ala Ser Ile His Leu Ser Cys Asn Arg Thr Ile 35 40 45 His Pro Leu Lys His Phe Asn Ser Asp Val Met Ala Ser Asp Asn Gly 50 55 60 Gly Ala Val Lys Leu Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Leu 65 70 75 80 Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr 85 90 95 Ala Ile Cys Glu Lys Pro His Glu Val Cys Val Ala Val Trp Arg Lys 100 105 110 Asn Asp Lys Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu 115 120 125 Thr Tyr His Gly Phe Thr Leu Glu Asp Ala Ala Ser Pro Lys Cys Val 130 135 140 Met Lys Glu Lys Lys Arg Ala Gly Glu Thr Phe Phe Met Cys Ala Cys 145 150 155 160 Asn Met Glu Glu Cys Asn Asp Tyr Ile Ile Phe Ser Glu Glu Tyr Thr 165 170 175 Thr Ser Ser Pro Asp Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 180 185 190 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 195 200 205 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Pro 210 215 220 Pro His Val Pro Lys Ser Asp Val Glu Met Glu Ala Gln Lys Asp Ala 225 230 235 240 Ser Ile His Leu Ser Cys Asn Arg Thr Ile His Pro Leu Lys His Phe 245 250 255 Asn Ser Asp Val Met Ala Ser Asp Asn Gly Gly Ala Val Lys Leu Pro 260 265 270 Gln Leu Cys Lys Phe Cys Asp Val Arg Leu Ser Thr Cys Asp Asn Gln 275 280 285 Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ala Ile Cys Glu Lys Pro 290 295 300 His Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Lys Asn Ile Thr 305 310 315 320 Leu Glu Thr Val Cys His Asp Pro Lys Leu Thr Tyr His Gly Phe Thr 325 330 335 Leu Glu Asp Ala Ala Ser Pro Lys Cys Val Met Lys Glu Lys Lys Arg 340 345 350 Ala Gly Glu Thr Phe Phe Met Cys Ala Cys Asn Met Glu Glu Cys Asn 355 360 365 Asp Tyr Ile Ile Phe Ser Glu Glu Tyr Thr Thr Ser Ser Pro Asp Leu 370 375 380 Gly Gly Gly Gly Ser Asp Tyr Lys Asp Asp Asp Asp Lys 385 390 395 <210> 39 <211> 384 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 39 Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 1 5 10 15 Gly Ser Thr Gly Ile Pro Pro His Val Pro Lys Ser Asp Val Glu Met 20 25 30 Glu Ala Gln Lys Asp Ala Ser Ile His Leu Ser Cys Asn Arg Thr Ile 35 40 45 His Pro Leu Lys His Phe Asn Ser Asp Val Met Ala Ser Asp Asn Gly 50 55 60 Gly Ala Val Lys Leu Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Leu 65 70 75 80 Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr 85 90 95 Ala Ile Cys Glu Lys Pro His Glu Val Cys Val Ala Val Trp Arg Lys 100 105 110 Asn Asp Lys Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu 115 120 125 Thr Tyr His Gly Phe Thr Leu Glu Asp Ala Ala Ser Pro Lys Cys Val 130 135 140 Met Lys Glu Lys Lys Arg Ala Gly Glu Thr Phe Phe Met Cys Ala Cys 145 150 155 160 Asn Met Glu Glu Cys Asn Asp Tyr Ile Ile Phe Ser Glu Glu Tyr Thr 165 170 175 Thr Ser Ser Pro Asp Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 180 185 190 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 195 200 205 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Pro 210 215 220 Pro His Val Pro Lys Ser Asp Val Glu Met Glu Ala Gln Lys Asp Ala 225 230 235 240 Ser Ile His Leu Ser Cys Asn Arg Thr Ile His Pro Leu Lys His Phe 245 250 255 Asn Ser Asp Val Met Ala Ser Asp Asn Gly Gly Ala Val Lys Leu Pro 260 265 270 Gln Leu Cys Lys Phe Cys Asp Val Arg Leu Ser Thr Cys Asp Asn Gln 275 280 285 Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ala Ile Cys Glu Lys Pro 290 295 300 His Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Lys Asn Ile Thr 305 310 315 320 Leu Glu Thr Val Cys His Asp Pro Lys Leu Thr Tyr His Gly Phe Thr 325 330 335 Leu Glu Asp Ala Ala Ser Pro Lys Cys Val Met Lys Glu Lys Lys Arg 340 345 350 Ala Gly Glu Thr Phe Phe Met Cys Ala Cys Asn Met Glu Glu Cys Asn 355 360 365 Asp Tyr Ile Ile Phe Ser Glu Glu Tyr Thr Thr Ser Ser Pro Asp Leu 370 375 380 <210> 40 <211> 92 <212> PRT <213> Homo sapiens <400> 40 Leu Gln Cys Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr Cys Val 1 5 10 15 Thr Asp Gly Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp Lys Val 20 25 30 Ile His Asn Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro Arg Asp 35 40 45 Arg Pro Phe Val Cys Ala Pro Ser Ser Lys Thr Gly Ser Val Thr Thr 50 55 60 Thr Tyr Cys Cys Asn Gln Asp His Cys Asn Lys Ile Glu Leu Pro Thr 65 70 75 80 Thr Val Lys Ser Ser Pro Gly Leu Gly Pro Val Glu 85 90 <210> 41 <211> 39 <212> PRT <213> Desconocida <220> <221> fuente <223> /nota="Descripción de Desconocida: Secuencia del dominio bisagra CD28" <400> 41 Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 1 5 10 15 Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 20 25 30 Phe Pro Gly Pro Ser Lys Pro 35 <210> 42 <211> 27 <212> PRT <213> Desconocida <220> <221> fuente <223> /nota="Descripción de Desconocida: Secuencia del dominio transmembrana CD28" <400> 42 Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 1 5 10 15 Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 20 25 <210> 43 <211> 66 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 43 Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 1 5 10 15 Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 20 25 30 Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 35 40 45 Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 50 55 60 Trp Val 65 <210> 44 <211> 41 <212> PRT <213> Desconocida <220> <221> fuente <223> /nota="Descripción de Desconocida: Secuencia del dominio de señal CD28" <400> 44 Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 1 5 10 15 Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 20 25 30 Pro Arg Asp Phe Ala Ala Tyr Arg Ser 35 40 <210> 45 <211> 112 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 45 Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 1 5 10 15 Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 20 25 30 Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 35 40 45 Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Phe Asn Glu Leu Gln Lys 50 55 60 Asp Lys Met Ala Glu Ala Phe Ser Glu Ile Gly Met Lys Gly Glu Arg 65 70 75 80 Arg Arg Gly Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala 85 90 95 Thr Lys Asp Thr Phe Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 100 105 110 <210> 46 <211> 219 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 46 Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 1 5 10 15 Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 20 25 30 Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 35 40 45 Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 50 55 60 Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 65 70 75 80 Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 85 90 95 Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser 100 105 110 Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 115 120 125 Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 130 135 140 Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 145 150 155 160 Pro Gln Glu Gly Leu Phe Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 165 170 175 Ala Phe Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 180 185 190 His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Phe 195 200 205 Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 210 215 <210> 47 <211> 359 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 47 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 20 25 30 Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Ile 35 40 45 Ser His Tyr Tyr Trp Ser Trp Phe Arg Gln Pro Ala Gly Lys Gly Leu 50 55 60 Glu Trp Ile Gly Arg Ile Tyr Pro Ser Gly Ser Thr Ser Tyr Asn Pro 65 70 75 80 Ser Leu Lys Ser Arg Val Ala Met Ser Val Asp Thr Pro Lys Asn Gln 85 90 95 Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 100 105 110 Tyr Cys Ala Arg Asp Arg Ser Thr Gly Trp Ser Glu Trp Asn Ser Asp 115 120 125 Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Ile Glu Val Met 130 135 140 Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile 145 150 155 160 His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro 165 170 175 Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 180 185 190 Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 195 200 205 Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 210 215 220 Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 225 230 235 240 Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp 245 250 255 Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 260 265 270 Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 275 280 285 Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 290 295 300 Leu Phe Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Phe Ser Glu 305 310 315 320 Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 325 330 335 Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Phe Asp Ala Leu His 340 345 350 Met Gln Ala Leu Pro Pro Arg 355 <210> 48 <211> 353 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 48 Met Glu Leu Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Glu Gly 1 5 10 15 Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 20 25 30 Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 35 40 45 Ser Arg Tyr Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 50 55 60 Glu Trp Val Ala Lys Ile Arg His Asp Gly Gly Glu Lys Tyr Tyr Ala 65 70 75 80 Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 85 90 95 Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 100 105 110 Tyr Tyr Cys Thr Arg Asp Tyr Asn Lys Asp Tyr Trp Gly Gln Gly Thr 115 120 125 Leu Val Thr Val Ser Ser Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu 130 135 140 Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His 145 150 155 160 Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val 165 170 175 Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 180 185 190 Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 195 200 205 His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 210 215 220 Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 225 230 235 240 Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 245 250 255 Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 260 265 270 Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 275 280 285 Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Phe Asn Glu Leu Gln 290 295 300 Lys Asp Lys Met Ala Glu Ala Phe Ser Glu Ile Gly Met Lys Gly Glu 305 310 315 320 Arg Arg Arg Gly Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser Thr 325 330 335 Ala Thr Lys Asp Thr Phe Asp Ala Leu His Met Gln Ala Leu Pro Pro 340 345 350 Arg <210> 49 <211> 526 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 49 Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 1 5 10 15 Asp His Ala Asp Ala Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 20 25 30 Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr 35 40 45 Ala Phe Ser Ser Ser Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys 50 55 60 Gly Leu Glu Trp Ile Gly Arg Ile Tyr Pro Gly Asp Glu Asp Thr Asn 65 70 75 80 Tyr Ser Gly Lys Phe Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser 85 90 95 Ser Thr Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser 100 105 110 Ala Val Tyr Phe Cys Ala Arg Ser Leu Leu Tyr Gly Asp Tyr Leu Asp 115 120 125 Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly 130 135 140 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Thr 145 150 155 160 Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met 165 170 175 Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln 180 185 190 Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu 195 200 205 Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 210 215 220 Tyr Phe Leu Thr Ile Asn Asn Met Glu Ala Glu Asp Ala Ala Thr Tyr 225 230 235 240 Tyr Cys Gln Gln Trp Asn Ile Asn Pro Leu Thr Phe Gly Ala Gly Thr 245 250 255 Lys Leu Glu Leu Lys Arg Ser Asp Pro Thr Thr Thr Pro Ala Pro Arg 260 265 270 Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 275 280 285 Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 290 295 300 Leu Asp Phe Ala Cys Asp Ile Phe Trp Val Leu Trp Val Gly Gly Val 305 310 315 320 Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 325 330 335 Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 340 345 350 Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 355 360 365 Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Asp Gln Arg Leu Pro 370 375 380 Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile 385 390 395 400 Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile Arg Val 405 410 415 Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 420 425 430 Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 435 440 445 Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 450 455 460 Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 465 470 475 480 Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 485 490 495 Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 500 505 510 Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 515 520 525 <210> 50 <211> 357 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 50 Met Glu Leu Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Glu Gly 1 5 10 15 Val Gln Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 20 25 30 Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe 35 40 45 Ser Arg Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 50 55 60 Glu Trp Val Ala Lys Ile Arg His Asp Gly Gly Glu Lys Tyr Tyr Val 65 70 75 80 Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 85 90 95 Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 100 105 110 Tyr Tyr Cys Ala Thr Asp Tyr Thr Arg Asp Val Trp Gly Gln Gly Thr 115 120 125 Ala Val Thr Val Ser Ser Arg Ala Ala Ala Ile Glu Val Met Tyr Pro 130 135 140 Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val 145 150 155 160 Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys 165 170 175 Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 180 185 190 Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 195 200 205 Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 210 215 220 Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 225 230 235 240 Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 245 250 255 Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 260 265 270 Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 275 280 285 Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Phe 290 295 300 Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Phe Ser Glu Ile Gly 305 310 315 320 Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Phe Gln 325 330 335 Gly Leu Ser Thr Ala Thr Lys Asp Thr Phe Asp Ala Leu His Met Gln 340 345 350 Ala Leu Pro Pro Arg 355 <210> 51 <211> 357 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 51 Met Glu Leu Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Glu Gly 1 5 10 15 Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Gln 20 25 30 Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 35 40 45 Ser Arg Tyr Trp Met Thr Trp Val Arg Gln Ala Pro Gly Gly Arg Leu 50 55 60 Glu Trp Val Ala Lys Ile Lys Tyr Asp Gly Ser Glu Lys Tyr Tyr Ala 65 70 75 80 Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 85 90 95 Ser Leu Tyr Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val 100 105 110 Tyr Tyr Cys Thr Arg Asp Tyr Asn Lys Asp Tyr Trp Gly Gln Gly Thr 115 120 125 Leu Val Thr Val Ser Ser Arg Ala Ala Ala Ile Glu Val Met Tyr Pro 130 135 140 Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val 145 150 155 160 Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys 165 170 175 Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 180 185 190 Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 195 200 205 Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 210 215 220 Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 225 230 235 240 Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 245 250 255 Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 260 265 270 Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 275 280 285 Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Phe 290 295 300 Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Phe Ser Glu Ile Gly 305 310 315 320 Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Phe Gln 325 330 335 Gly Leu Ser Thr Ala Thr Lys Asp Thr Phe Asp Ala Leu His Met Gln 340 345 350 Ala Leu Pro Pro Arg 355 <210> 52 <211> 363 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 52 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 20 25 30 Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Ile 35 40 45 Ser His Tyr Tyr Trp Ser Trp Phe Arg Gln Pro Ala Gly Lys Gly Leu 50 55 60 Glu Trp Ile Gly Arg Ile Tyr Pro Ser Gly Ser Thr Ser Tyr Asn Pro 65 70 75 80 Ser Leu Lys Ser Arg Val Ala Met Ser Val Asp Thr Pro Lys Asn Gln 85 90 95 Phe Ser Leu Asn Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 100 105 110 Tyr Cys Ala Arg Asp Arg Ser Thr Gly Trp Ser Glu Trp Asn Ser Asp 115 120 125 Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Arg Ala Ala Ala 130 135 140 Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 145 150 155 160 Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 165 170 175 Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 180 185 190 Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 195 200 205 Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 210 215 220 Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 225 230 235 240 Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser 245 250 255 Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 260 265 270 Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 275 280 285 Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 290 295 300 Pro Gln Glu Gly Leu Phe Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 305 310 315 320 Ala Phe Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 325 330 335 His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Phe 340 345 350 Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 355 360 <210> 53 <211> 357 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 53 Met Glu Leu Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Glu Gly 1 5 10 15 Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 20 25 30 Pro Gly Gly Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Phe Thr Phe 35 40 45 Ser Arg Tyr Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 50 55 60 Glu Trp Val Ala Lys Ile Arg His Asp Gly Gly Glu Lys Tyr Tyr Pro 65 70 75 80 Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn 85 90 95 Ser Leu Tyr Leu Gln Met Asp Asn Leu Arg Ala Glu Asp Thr Ala Met 100 105 110 Tyr Tyr Cys Thr Arg Asp Tyr Asn Lys Asp Leu Trp Gly Gln Gly Thr 115 120 125 Leu Val Thr Val Ser Ser Arg Ala Ala Ala Ile Glu Val Met Tyr Pro 130 135 140 Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val 145 150 155 160 Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys 165 170 175 Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 180 185 190 Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 195 200 205 Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 210 215 220 Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 225 230 235 240 Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 245 250 255 Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 260 265 270 Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 275 280 285 Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Phe 290 295 300 Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Phe Ser Glu Ile Gly 305 310 315 320 Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Phe Gln 325 330 335 Gly Leu Ser Thr Ala Thr Lys Asp Thr Phe Asp Ala Leu His Met Gln 340 345 350 Ala Leu Pro Pro Arg 355 <210> 54 <211> 338 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 54 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Lys Ile Lys Tyr Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Val Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Val Tyr Tyr Cys 85 90 95 Ala Thr Asp Phe Thr Arg Asp Val Trp Gly Gln Gly Thr Thr Val Thr 100 105 110 Val Ser Ser Arg Ala Ala Ala Ile Glu Val Met Tyr Pro Pro Pro Tyr 115 120 125 Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys 130 135 140 His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp 145 150 155 160 Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 165 170 175 Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 180 185 190 Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 195 200 205 Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 210 215 220 Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 225 230 235 240 Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 245 250 255 Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 260 265 270 Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Phe Asn Glu Leu 275 280 285 Gln Lys Asp Lys Met Ala Glu Ala Phe Ser Glu Ile Gly Met Lys Gly 290 295 300 Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser 305 310 315 320 Thr Ala Thr Lys Asp Thr Phe Asp Ala Leu His Met Gln Ala Leu Pro 325 330 335 Pro Arg <210> 55 <211> 338 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 55 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 20 25 30 Trp Met Thr Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val 35 40 45 Ala Lys Ile Arg Tyr Asp Gly Gly Glu Lys Tyr Tyr Val Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Thr Asp Phe Thr Arg Asp Val Trp Gly Gln Gly Thr Thr Val Thr 100 105 110 Val Ser Ser Arg Ala Ala Ala Ile Glu Val Met Tyr Pro Pro Pro Tyr 115 120 125 Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys 130 135 140 His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp 145 150 155 160 Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 165 170 175 Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 180 185 190 Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 195 200 205 Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 210 215 220 Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 225 230 235 240 Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 245 250 255 Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 260 265 270 Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Phe Asn Glu Leu 275 280 285 Gln Lys Asp Lys Met Ala Glu Ala Phe Ser Glu Ile Gly Met Lys Gly 290 295 300 Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser 305 310 315 320 Thr Ala Thr Lys Asp Thr Phe Asp Ala Leu His Met Gln Ala Leu Pro 325 330 335 Pro Arg <210> 56 <211> 338 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 56 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Phe Gly Arg Tyr 20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Arg Glu Trp Val 35 40 45 Ala Lys Ile Lys Tyr Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Thr Asp Phe Thr Arg Asp Val Trp Gly Gln Gly Thr Thr Val Thr 100 105 110 Val Ser Ser Arg Ala Ala Ala Ile Glu Val Met Tyr Pro Pro Pro Tyr 115 120 125 Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys 130 135 140 His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp 145 150 155 160 Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 165 170 175 Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 180 185 190 Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 195 200 205 Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 210 215 220 Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 225 230 235 240 Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 245 250 255 Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 260 265 270 Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Phe Asn Glu Leu 275 280 285 Gln Lys Asp Lys Met Ala Glu Ala Phe Ser Glu Ile Gly Met Lys Gly 290 295 300 Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser 305 310 315 320 Thr Ala Thr Lys Asp Thr Phe Asp Ala Leu His Met Gln Ala Leu Pro 325 330 335 Pro Arg <210> 57 <211> 338 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 57 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Arg Glu Trp Val 35 40 45 Ala Lys Ile Lys Tyr Asp Gly Ser Glu Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Thr Asp Phe Thr Arg Asp Val Trp Gly Gln Gly Thr Thr Val Thr 100 105 110 Val Ser Ser Arg Ala Ala Ala Ile Glu Val Met Tyr Pro Pro Pro Tyr 115 120 125 Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys 130 135 140 His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp 145 150 155 160 Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 165 170 175 Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 180 185 190 Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 195 200 205 Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 210 215 220 Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 225 230 235 240 Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 245 250 255 Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 260 265 270 Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Phe Asn Glu Leu 275 280 285 Gln Lys Asp Lys Met Ala Glu Ala Phe Ser Glu Ile Gly Met Lys Gly 290 295 300 Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser 305 310 315 320 Thr Ala Thr Lys Asp Thr Phe Asp Ala Leu His Met Gln Ala Leu Pro 325 330 335 Pro Arg <210> 58 <211> 22 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Péptido sintético" <400> 58 Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 1 5 10 15 Glu Glu Asn Pro Gly Pro 20 <210> 59 <211> 5 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Péptido sintético" <400> 59 Gly Gly Gly Gly Ser 1 5 <210> 60 <211> 10 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Péptido sintético" <400> 60 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 1 5 10 <210> 61 <211> 15 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Péptido sintético" <400> 61 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 1 5 10 15 <210> 62 <211> 481 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 62 Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 1 5 10 15 Gly Ser Thr Gly Glu Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Val 20 25 30 Arg Pro Gly Ser Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala 35 40 45 Phe Ser Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly 50 55 60 Leu Glu Trp Ile Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr 65 70 75 80 Asn Gly Lys Phe Lys Gly Gln Ala Thr Leu Thr Ala Asp Lys Ser Ser 85 90 95 Ser Thr Ala Tyr Met Gln Leu Ser Gly Leu Thr Ser Glu Asp Ser Ala 100 105 110 Val Tyr Phe Cys Ala Arg Lys Thr Ile Ser Ser Val Val Asp Phe Tyr 115 120 125 Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly 130 135 140 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu 145 150 155 160 Leu Thr Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val 165 170 175 Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala Trp 180 185 190 Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Pro Leu Ile Tyr Ser Ala 195 200 205 Thr Tyr Arg Asn Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser 210 215 220 Gly Thr Asp Phe Thr Leu Thr Ile Thr Asn Val Gln Ser Lys Asp Leu 225 230 235 240 Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Arg Tyr Pro Tyr Thr Ser Gly 245 250 255 Gly Gly Thr Lys Leu Glu Ile Lys Ile Glu Phe Met Tyr Pro Pro Pro 260 265 270 Tyr Leu Asp Asn Glu Arg Ser Asn Gly Thr Ile Ile His Ile Lys Glu 275 280 285 Lys His Leu Cys His Thr Gln Ser Ser Pro Lys Leu Phe Trp Ala Leu 290 295 300 Val Val Val Ala Gly Val Leu Phe Cys Tyr Gly Leu Leu Val Thr Val 305 310 315 320 Ala Leu Cys Val Ile Trp Thr Asn Ser Arg Arg Asn Arg Leu Leu Gln 325 330 335 Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Leu Thr Arg Lys 340 345 350 Pro Tyr Gln Pro Tyr Ala Pro Ala Arg Asp Phe Ala Ala Tyr Arg Pro 355 360 365 Arg Ala Lys Phe Ser Arg Ser Ala Glu Thr Ala Ala Asn Leu Gln Asp 370 375 380 Pro Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 385 390 395 400 Asp Val Leu Glu Lys Lys Arg Ala Arg Asp Pro Glu Met Gly Gly Lys 405 410 415 Gln Gln Arg Arg Arg Asn Pro Gln Glu Gly Val Tyr Asn Ala Leu Gln 420 425 430 Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Thr Lys Gly Glu 435 440 445 Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 450 455 460 Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Thr Leu Ala Pro 465 470 475 480 Arg <210> 63 <211> 485 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 63 Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 1 5 10 15 His Ala Glu Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro 20 25 30 Gly Ser Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser 35 40 45 Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu 50 55 60 Trp Ile Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly 65 70 75 80 Lys Phe Lys Gly Gln Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 85 90 95 Ala Tyr Met Gln Leu Ser Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr 100 105 110 Phe Cys Ala Arg Lys Thr Ile Ser Ser Val Val Asp Phe Tyr Phe Asp 115 120 125 Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 130 135 140 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr 145 150 155 160 Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Val 165 170 175 Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala Trp Tyr Gln 180 185 190 Gln Lys Pro Gly Gln Ser Pro Lys Pro Leu Ile Tyr Ser Ala Thr Tyr 195 200 205 Arg Asn Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr 210 215 220 Asp Phe Thr Leu Thr Ile Thr Asn Val Gln Ser Lys Asp Leu Ala Asp 225 230 235 240 Tyr Phe Cys Gln Gln Tyr Asn Arg Tyr Pro Tyr Thr Ser Gly Gly Gly 245 250 255 Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala Ile Glu Val Met Tyr Pro 260 265 270 Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val 275 280 285 Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys 290 295 300 Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 305 310 315 320 Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 325 330 335 Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 340 345 350 Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 355 360 365 Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 370 375 380 Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 385 390 395 400 Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 405 410 415 Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Phe 420 425 430 Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Phe Ser Glu Ile Gly 435 440 445 Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Phe Gln 450 455 460 Gly Leu Ser Thr Ala Thr Lys Asp Thr Phe Asp Ala Leu His Met Gln 465 470 475 480 Ala Leu Pro Pro Arg 485 <210> 64 <211> 50 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <220> <221> SITE <222> (1)..(50) <223> /nota="Esta secuencia puede abarcar 1-10 unidades de repetición 'Gly Gly Gly Gly Ser'" <400> 64 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 1 5 10 15 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 20 25 30 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 35 40 45 Gly Ser 50 <210> 65 <211> 40 <212> PRT <213> Secuencia Artificial <220> <221> fuente <223> /nota="Descripción de la Secuencia Artificial: Polipéptido sintético" <400> 65 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 1 5 10 15 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 20 25 30 Gly Gly Ser Gly Gly Gly Gly Ser 35 40