LISTADO DE SECUENCIAS <110> Arbor Biotechnologies, Inc. <120> COMPOSICIONES QUE COMPRENDEN UNA VARIANTE DEL POLIPÉPTIDO CAS12I4 Y USOS DE LAS MISMAS <130> 51451-023WO3 <150> US 63/154,437 <151> 2021-02-26 <150> US 63/148,421 <151> 2021-02-11 <160> 228 <170> PatentIn versión 3.5 <210> 1 <211> 3222 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 1 atggcttcca tctctaggcc atacggcacc aagctgcgac cggacgcacg gaagaaggag 60 atgctcgata agttctttaa tacactgact aagggtcagc gcgtgttcgc agacctggcc 120 ctgtgcatct atggctccct gaccctggag atggccaagt ctctggagcc agaaagtgat 180 tcagaactgg tgtgcgctat tgggtggttt cggctggtgg acaagaccat ctggtccaag 240 gatggcatca agcaggagaa tctggtgaaa cagtacgaag cctattccgg aaaggaggct 300 tctgaagtgg tcaaaacata cctgaacagc cccagctccg acaagtacgt gtggatcgat 360 tgcaggcaga aattcctgag gtttcagcgc gagctcggca ctcgcaacct gtccgaggac 420 ttcgaatgta tgctctttga acagtacatt agactgacca agggcgagat cgaagggtat 480 gccgctattt caaatatgtt cggaaacggc gagaaggaag accggagcaa gaaaagaatg 540 tacgctacac ggatgaaaga ttggctggag gcaaacgaaa atatcacttg ggagcagtat 600 agagaggccc tgaagaacca gctgaatgct aaaaacctgg agcaggttgt ggccaattac 660 aaggggaacg ctggcggggc agaccccttc tttaagtata gcttctccaa agagggaatg 720 gtgagcaaga aagaacatgc acagcagctc gacaagttca aaaccgtcct gaagaacaaa 780 gcccgggacc tgaattttcc aaacaaggag aagctgaagc agtacctgga ggccgaaatc 840 ggcattccgg tcgacgctaa cgtgtactcc cagatgttct ctaacggggt gagtgaggtc 900 cagcctaaga ccacacggaa tatgtctttt agtaacgaga aactggatct gctcactgaa 960 ctgaaggacc tgaacaaggg cgatgggttc gagtacgcca gagaagtgct gaacgggttc 1020 tttgactccg agctccacac taccgaggat aagtttaata tcacctctag gtacctggga 1080 ggcgacaaat caaaccgcct gagcaaactc tataagatct ggaagaaaga gggtgtggac 1140 tgcgaggaag gcattcagca gttctgtgaa gccgtcaaag ataagatggg ccagatcccc 1200 attcgaaatg tgctgaagta cctgtggcag ttccgggaga cagtcagtgc cgaggatttt 1260 gaagcagccg ctaaggctaa ccatctggag gaaaagatca gccgggtgaa agcccaccca 1320 atcgtgatta gcaataggta ctgggctttt gggacttccg cactggtggg aaacattatg 1380 cccgcagaca agaggcatca gggagagtat gccggtcaga atttcaaaat gtggctggag 1440 gctgaactgc actacgatgg caagaaagca aagcaccatc tgccttttta taacgcccgc 1500 ttctttgagg aagtgtactg ctatcacccc tctgtcgccg agatcactcc tttcaaaacc 1560 aagcagtttg gctgtgaaat cgggaaggac attccagatt acgtgagcgt cgctctgaag 1620 gacaatccgt ataagaaagc aaccaaacga atcctgcgtg caatctacaa tcccgtcgcc 1680 aacacaactg gcgttgataa gaccacaaac tgcagcttca tgatcaaacg cgagaatgac 1740 gaatataagc tggtcatcaa ccgaaaaatt tccgtggatc ggcctaagag aatcgaagtg 1800 ggcaggacaa ttatggggta cgaccgcaat cagacagcta gcgatactta ttggattggc 1860 cggctggtgc cacctggaac ccggggcgca taccgcatcg gagagtggag cgtccagtat 1920 attaagtccg ggcctgtcct gtctagtact cagggagtta acaattccac taccgaccag 1980 ctggtgtaca acggcatgcc atcaagctcc gagcggttca aggcctggaa gaaagccaga 2040 atggctttta tccgaaaact cattcgtcag ctgaatgacg agggactgga atctaagggt 2100 caggattata tccccgagaa cccttctagt ttcgatgtgc ggggcgaaac cctgtacgtc 2160 tttaacagta attatctgaa ggccctggtg agcaaacaca gaaaggccaa gaaacctgtt 2220 gaggggatcc tggacgagat tgaagcctgg acatctaaag acaaggattc atgcagcctg 2280 atgcggctga gcagcctgag cgatgcttcc atgcagggaa tcgccagcct gaagagtctg 2340 attaacagct acttcaacaa gaatggctgt aaaaccatcg aggacaaaga aaagtttaat 2400 cccgtgctgt atgccaagct ggttgaggtg gaacagcgga gaacaaacaa gcggtctgag 2460 aaagtgggaa gaatcgcagg tagtctggag cagctggccc tgctgaacgg ggttgaggtg 2520 gtcatcggcg aagctgacct gggggaggtc gaaaaaggaa agagtaagaa acagaattca 2580 cggaacatgg attggtgcgc aaagcaggtg gcacagcggc tggagtacaa actggccttc 2640 catggaatcg gttactttgg agtgaacccc atgtatacca gccaccagga ccctttcgaa 2700 cataggcgcg tggctgatca catcgtcatg cgagcacgtt ttgaggaagt caacgtggag 2760 aacattgccg aatggcacgt gcgaaatttc tcaaactacc tgcgtgcaga cagcggcact 2820 gggctgtact ataagcaggc caccatggac ttcctgaaac attacggtct ggaggaacac 2880 gctgagggcc tggaaaataa gaaaatcaag ttctatgact ttagaaagat cctggaggat 2940 aaaaacctga caagcgtgat cattccaaag aggggcgggc gcatctacat ggccaccaac 3000 ccagtgacat ccgactctac cccgattaca tacgccggca agacttataa taggtgtaac 3060 gctgatgagg tggcagccgc taatatcgtt atttctgtgc tggctccccg cagtaagaaa 3120 aacgaggaac aggacgatat ccctctgatt accaagaaag ccgagagtaa gtcaccaccg 3180 aaagaccgga agagatcaaa aacaagccag ctgcctcaga aa 3222 <210> 2 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 2 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Glu 465 470 475 480 Ala Glu Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Gly Val Asp Lys Thr Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Val 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Asp Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Phe Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Glu Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 3 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 3 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Glu 465 470 475 480 Ala Glu Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Gly Val Asp Lys Thr Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Arg 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Asp Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Phe Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Arg Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 4 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 4 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Arg 465 470 475 480 Ala Glu Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Arg Val Asp Lys Thr Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Arg 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Asp Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Phe Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Arg Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 5 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 5 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Arg 465 470 475 480 Ala Glu Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Arg Val Asp Lys Thr Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Val 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Asp Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Phe Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Glu Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 6 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 6 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Arg 465 470 475 480 Ala Glu Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Gly Val Asp Lys Thr Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Arg 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Asp Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Phe Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Glu Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 7 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 7 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Arg 465 470 475 480 Ala Glu Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Gly Val Asp Lys Thr Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Val 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Asp Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Phe Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Arg Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 8 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 8 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Arg 465 470 475 480 Ala Gly Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Gly Val Asp Lys Thr Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Val 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Asp Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Phe Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Glu Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 9 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 9 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Glu 465 470 475 480 Ala Glu Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Arg Val Asp Lys Thr Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Arg 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Asp Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Phe Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Glu Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 10 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 10 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Glu 465 470 475 480 Ala Glu Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Arg Val Asp Lys Thr Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Val 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Asp Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Phe Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Arg Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 11 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 11 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Glu 465 470 475 480 Ala Gly Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Arg Val Asp Lys Thr Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Val 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Asp Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Phe Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Glu Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 12 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 12 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Glu 465 470 475 480 Ala Gly Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Gly Val Asp Lys Thr Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Arg 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Asp Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Phe Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Glu Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 13 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 13 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Glu 465 470 475 480 Ala Gly Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Gly Val Asp Lys Thr Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Val 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Asp Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Phe Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Arg Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 14 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 14 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Arg 465 470 475 480 Ala Glu Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Arg Val Asp Lys Thr Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Arg 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Asp Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Phe Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Glu Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 15 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 15 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Arg 465 470 475 480 Ala Glu Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Arg Val Asp Lys Thr Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Val 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Asp Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Phe Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Arg Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 16 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 16 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Arg 465 470 475 480 Ala Gly Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Arg Val Asp Lys Thr Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Val 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Asp Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Phe Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Glu Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 17 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 17 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Arg 465 470 475 480 Ala Glu Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Gly Val Asp Lys Thr Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Arg 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Asp Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Phe Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Arg Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 18 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 18 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Arg 465 470 475 480 Ala Gly Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Gly Val Asp Lys Thr Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Arg 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Asp Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Phe Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Glu Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 19 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 19 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Arg 465 470 475 480 Ala Gly Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Gly Val Asp Lys Thr Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Val 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Asp Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Phe Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Arg Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 20 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 20 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Glu 465 470 475 480 Ala Glu Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Arg Val Asp Lys Thr Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Arg 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Asp Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Phe Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Arg Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 21 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 21 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Glu 465 470 475 480 Ala Gly Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Arg Val Asp Lys Thr Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Arg 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Asp Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Phe Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Glu Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 22 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 22 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Glu 465 470 475 480 Ala Gly Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Arg Val Asp Lys Thr Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Val 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Asp Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Phe Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Arg Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 23 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 23 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Glu 465 470 475 480 Ala Gly Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Gly Val Asp Lys Thr Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Arg 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Asp Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Phe Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Arg Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 24 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 24 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Arg 465 470 475 480 Ala Gly Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Arg Val Asp Lys Thr Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Arg 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Asp Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Phe Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Glu Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 25 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 25 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Arg 465 470 475 480 Ala Gly Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Arg Val Asp Lys Thr Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Val 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Asp Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Phe Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Arg Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 26 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 26 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Arg 465 470 475 480 Ala Gly Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Gly Val Asp Lys Thr Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Arg 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Asp Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Phe Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Arg Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 27 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 27 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Glu 465 470 475 480 Ala Gly Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Arg Val Asp Lys Thr Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Arg 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Asp Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Phe Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Arg Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 28 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 28 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Arg 465 470 475 480 Ala Gly Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Arg Val Asp Lys Thr Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Arg 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Asp Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Phe Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Arg Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 29 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 29 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Arg 465 470 475 480 Ala Glu Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Arg Val Asp Lys Arg Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Arg 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Asp Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Phe Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Arg Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 30 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 30 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Arg 465 470 475 480 Ala Glu Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Arg Val Asp Lys Thr Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Arg Arg 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Asp Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Phe Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Arg Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 31 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 31 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Arg 465 470 475 480 Ala Glu Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Arg Val Asp Lys Thr Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Arg 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Gly Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Phe Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Arg Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 32 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 32 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Arg 465 470 475 480 Ala Glu Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Arg Val Asp Lys Thr Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Arg 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Asp Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Arg Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Arg Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 33 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 33 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Arg 465 470 475 480 Ala Glu Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Arg Val Asp Lys Arg Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Arg Arg 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Asp Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Phe Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Arg Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 34 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 34 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Arg 465 470 475 480 Ala Glu Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Arg Val Asp Lys Arg Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Arg 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Gly Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Phe Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Arg Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 35 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 35 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Arg 465 470 475 480 Ala Glu Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Arg Val Asp Lys Arg Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Arg 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Asp Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Arg Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Arg Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 36 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 36 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Arg 465 470 475 480 Ala Glu Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Arg Val Asp Lys Thr Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Arg Arg 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Gly Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Phe Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Arg Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 37 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 37 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Arg 465 470 475 480 Ala Glu Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Arg Val Asp Lys Thr Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Arg Arg 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Asp Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Arg Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Arg Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 38 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 38 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Arg 465 470 475 480 Ala Glu Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Arg Val Asp Lys Thr Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Arg 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Gly Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Arg Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Arg Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 39 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 39 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Arg 465 470 475 480 Ala Glu Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Arg Val Asp Lys Arg Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Arg Arg 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Gly Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Phe Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Arg Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 40 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 40 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Arg 465 470 475 480 Ala Glu Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Arg Val Asp Lys Arg Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Arg Arg 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Asp Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Arg Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Arg Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 41 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 41 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Arg 465 470 475 480 Ala Glu Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Arg Val Asp Lys Arg Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Arg 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Gly Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Arg Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Arg Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 42 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 42 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Arg 465 470 475 480 Ala Glu Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Arg Val Asp Lys Thr Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Arg Arg 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Gly Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Arg Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Arg Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 43 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 43 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Arg 465 470 475 480 Ala Glu Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Arg Val Asp Lys Arg Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Arg Arg 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Gly Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Arg Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Arg Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 44 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 44 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Arg 465 470 475 480 Ala Glu Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Gly Val Asp Lys Arg Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Arg 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Asp Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Phe Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Glu Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 45 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 45 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Arg 465 470 475 480 Ala Glu Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Gly Val Asp Lys Arg Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Val 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Gly Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Phe Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Glu Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 46 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 46 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Arg 465 470 475 480 Ala Glu Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Gly Val Asp Lys Arg Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Val 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Asp Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Arg Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Glu Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 47 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 47 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Arg 465 470 475 480 Ala Glu Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Gly Val Asp Lys Thr Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Arg 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Gly Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Phe Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Glu Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 48 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 48 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Arg 465 470 475 480 Ala Glu Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Gly Val Asp Lys Thr Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Arg 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Asp Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Arg Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Glu Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 49 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 49 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Arg 465 470 475 480 Ala Glu Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Gly Val Asp Lys Thr Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Val 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Gly Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Arg Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Glu Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 50 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 50 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Glu 465 470 475 480 Ala Glu Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Gly Val Asp Lys Arg Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Arg 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Gly Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Phe Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Glu Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 51 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 51 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Glu 465 470 475 480 Ala Glu Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Gly Val Asp Lys Arg Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Arg 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Asp Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Arg Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Glu Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 52 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 52 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Glu 465 470 475 480 Ala Glu Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Gly Val Asp Lys Arg Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Val 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Gly Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Arg Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Glu Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 53 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 53 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Glu 465 470 475 480 Ala Glu Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Gly Val Asp Lys Thr Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Arg 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Gly Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Arg Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Glu Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 54 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 54 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Arg 465 470 475 480 Ala Glu Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Gly Val Asp Lys Arg Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Arg 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Gly Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Phe Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Glu Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 55 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 55 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Arg 465 470 475 480 Ala Glu Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Gly Val Asp Lys Arg Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Arg 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Asp Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Arg Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Glu Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 56 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 56 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Arg 465 470 475 480 Ala Glu Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Gly Val Asp Lys Arg Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Val 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Gly Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Arg Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Glu Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 57 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 57 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Arg 465 470 475 480 Ala Glu Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Gly Val Asp Lys Thr Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Arg 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Gly Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Arg Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Glu Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 58 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 58 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Glu 465 470 475 480 Ala Glu Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Gly Val Asp Lys Arg Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Arg 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Gly Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Arg Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Glu Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 59 <211> 1074 <212> PRT <213> Secuencia artificial <220> <223> Constructo sintético <400> 59 Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 1 5 10 15 Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 20 25 30 Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 35 40 45 Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 50 55 60 Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 65 70 75 80 Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 85 90 95 Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 100 105 110 Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 115 120 125 Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 130 135 140 Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 145 150 155 160 Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 165 170 175 Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 180 185 190 Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 195 200 205 Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 210 215 220 Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 225 230 235 240 Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 245 250 255 Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 260 265 270 Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 275 280 285 Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 290 295 300 Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 305 310 315 320 Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 325 330 335 Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 340 345 350 Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 355 360 365 Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 370 375 380 Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 385 390 395 400 Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 405 410 415 Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 420 425 430 Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 435 440 445 Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 450 455 460 Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Arg 465 470 475 480 Ala Glu Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 485 490 495 Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 500 505 510 Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 515 520 525 Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 530 535 540 Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 545 550 555 560 Asn Thr Thr Gly Val Asp Lys Arg Thr Asn Cys Ser Phe Met Ile Lys 565 570 575 Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Arg 580 585 590 Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 595 600 605 Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 610 615 620 Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 625 630 635 640 Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 645 650 655 Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 660 665 670 Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 675 680 685 Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 690 695 700 Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 705 710 715 720 Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 725 730 735 Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 740 745 750 Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 755 760 765 Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 770 775 780 Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 785 790 795 800 Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 805 810 815 Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 820 825 830 Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Gly Leu Gly 835 840 845 Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 850 855 860 Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 865 870 875 880 His Gly Ile Gly Tyr Arg Gly Val Asn Pro Met Tyr Thr Ser His Gln 885 890 895 Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 900 905 910 Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 915 920 925 Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 930 935 940 Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 945 950 955 960 Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 965 970 975 Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 980 985 990 Gly Arg Ile Tyr Met Ala Thr Asn Pro Val Thr Ser Asp Ser Thr Pro 995 1000 1005 Ile Thr Tyr Ala Gly Lys Thr Tyr Asn Arg Cys Asn Ala Asp Glu 1010 1015 1020 Val Ala Ala Ala Asn Ile Val Ile Ser Val Leu Ala Pro Arg Ser 1025 1030 1035 Lys Lys Asn Glu Glu Gln Asp Asp Ile Pro Leu Ile Thr Lys Lys 1040 1045 1050 Ala Glu Ser Lys Ser Pro Pro Lys Asp Arg Lys Arg Ser Lys Thr 1055 1060 1065 Ser Gln Leu Pro Gln Lys 1070 <210> 60 <211> 36 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 60 ucucaacgau agucagacau guguccucag ugacac 36 <210> 61 <211> 22 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 61 agacaugugu ccucagugac ac 22 <210> 62 <211> 40 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 62 agacaugugu ccucagugac acguagccuc ucccgcucug 40 <210> 63 <211> 40 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 63 agacaugugu ccucagugac acgggaagug guuggucagc 40 <210> 64 <211> 40 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 64 agacaugugu ccucagugac acggggaggc cuggagucau 40 <210> 65 <211> 592 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 65 cgcaaagtgt tgggattaca ggcgtgagcc cggccattct gagactgtgt tgcaggcatt 60 gtacatcttc gcctgatgca cagcaggtat ctcctgccac aaggaaaacc tcctgcagaa 120 ccacagtagg gatgcaacac gctaccccct gtgttgacct tgatgctaca ctctcaccca 180 ccgcaccaac cttgatgcta cactctcacc caccgcacca accttgatgc tacactctca 240 cccaccgcac caaccttgat gctacactct cacccaccgc accaaccttg atgctacact 300 ctcacccacc gcaccaacct tgatgctaca ctctcaccca ctgcaccaac cttgatgcta 360 cactgttgcc tgcgtttctc cttgacattc tttgtagcct ctcccgctct ggttcagggc 420 ccagctaggg atccagatct gggtgattta ggctccctct gtctggatca gtcctccttt 480 tcccttggac cccagggagg ccgggaatgg cctccagggg gtctgtgaac tttctgacgt 540 tgtattttcc tgcagaaatt gctcataact tgcatcagct tctcagaggg gg 592 <210> 66 <211> 614 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 66 cctgagccca tcactgttgc aaaggtgaca ggaaggcctg gtgatgtgcg caccctggag 60 ccaggctatg ggcccggtca cattgaaacc atatggggca aagtgtgggt gaggaaagtc 120 aagatgaggt cacaggggaa gggagaatgg attttcgtag gcccaagcag cagctgtgct 180 gcagggacac gcagcagcac catgtcctgt gcagaaggga ccctccctgg ccactttgca 240 caggggcatg gaactggcag gaagaagaca tgatgtgttt ttgaaacatt tgaagccagc 300 tcacttggaa ttccagcatc caagtcagct ggaagagggg gagttaccct tggaggcagg 360 cggaatcgac cattggatag ctccaagtgc tgacaagggc ggacacggga gctgatttct 420 gcctggtggg aaaggtgatg attccagcta ctttgggaag tggttggtca gcatggatta 480 tagccgaagg ccccagcttt gccttgttct agcagttcca ctcctgggca gcccgagaga 540 ggccttccca accatgggca gatgttcatc atagtattgt ttgcagtagt aagaggtcgg 600 agcccacacc aaag 614 <210> 67 <211> 490 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 67 aggacaaagt acaaacggca gaagctggag gaggaagggc ctgagtccga gcagaagaag 60 aagggctccc atcacatcaa ccggtggcgc attgccacga agcaggccaa tggggaggac 120 atcgatgtca cctccaatga ctagggtggg caaccacaaa cccacgaggg cagagtgctg 180 cttgctgctg gccaggcccc tgcgtgggcc caagctggac tctggccact ccctggccag 240 gctttgggga ggcctggagt catggcccca cagggcttga agcccggggc cgccattgac 300 agagggacaa gcaatgggct ggctgaggcc tgggaccact tggccttctc ctcggagagc 360 ctgcctgcct gggcgggccc gcccgccacc gcagcctccc agctgctctc cgtgtctcca 420 atctcccttt tgttttgatg catttctgtt ttaatttatt ttccaggcac cactgtagtt 480 tagtgatccc 490 <210> 68 <211> 25 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 68 cgcaaagtgt tgggattaca ggcgt 25 <210> 69 <211> 25 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 69 ccccctctga gaagctgatg caagt 25 <210> 70 <211> 25 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 70 ccccctctga gaagctgatg caagt 25 <210> 71 <211> 25 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 71 ctttggtgtg ggctccgacc tctta 25 <210> 72 <211> 28 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 72 aggacaaagt acaaacggca gaagctgg 28 <210> 73 <211> 28 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 73 gggatcacta aactacagtg gtgcctgg 28 <210> 74 <211> 46 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 74 agacaugugu ccucagugac acuguccccc caaguuuugg accccu 46 <210> 75 <211> 24 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 75 tgtcccccca agttttggac ccct 24 <210> 76 <211> 46 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 76 agacaugugu ccucagugac acgugagaau ggugcguccu aggugu 46 <210> 77 <211> 24 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 77 gtgagaatgg tgcgtcctag gtgt 24 <210> 78 <211> 46 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 78 agacaugugu ccucagugac acaacuggcc cuggcuuugg cagccu 46 <210> 79 <211> 24 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 79 aactggccct ggctttggca gcct 24 <210> 80 <211> 46 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 80 agacaugugu ccucagugac acguagccuc ucccgcucug guucag 46 <210> 81 <211> 24 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 81 gtagcctctc ccgctctggt tcag 24 <210> 82 <211> 46 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 82 agacaugugu ccucagugac acgggaagug guuggucagc auggau 46 <210> 83 <211> 24 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 83 gggaagtggt tggtcagcat ggat 24 <210> 84 <211> 46 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 84 agacaugugu ccucagugac acgggaagug guuggucagc auggau 46 <210> 85 <211> 24 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 85 gggcgcaggg ccacctggac cctg 24 <210> 86 <211> 46 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 86 agacaugugu ccucagugac acggauggcg acuucaggca caggau 46 <210> 87 <211> 24 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 87 ggatggcgac ttcaggcaca ggat 24 <210> 88 <211> 46 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 88 agacaugugu ccucagugac acggggaggc cuggagucau ggcccc 46 <210> 89 <211> 24 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 89 ggggaggcct ggagtcatgg cccc 24 <210> 90 <211> 46 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 90 agacaugugu ccucagugac acgagccagu guugcuaguc aagggc 46 <210> 91 <211> 24 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 91 gagccagtgt tgctagtcaa gggc 24 <210> 92 <211> 46 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 92 agacaugugu ccucagugac acagcaaggg acuauucagg gaugaa 46 <210> 93 <211> 24 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 93 agcaagggac tattcaggga tgaa 24 <210> 94 <211> 46 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 94 agacaugugu ccucagugac acaaaauuga gcaaucuacc cugguc 46 <210> 95 <211> 24 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 95 aaaattgagc aatctaccct ggtc 24 <210> 96 <211> 46 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 96 agacaugugu ccucagugac acugggggug accgccggag cgcggc 46 <210> 97 <211> 24 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 97 tgggggtgac cgccggagcg cggc 24 <210> 98 <211> 46 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 98 agacaugugu ccucagugac acaauccucc accagucaug gugaca 46 <210> 99 <211> 24 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 99 aatcctccac cagtcatggt gaca 24 <210> 100 <211> 46 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 100 agacaugugu ccucagugac acguugacau uguccacacc uggaau 46 <210> 101 <211> 24 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 101 gttgacattg tccacacctg gaat 24 <210> 102 <211> 46 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 102 agacaugugu ccucagugac acuuaaacuc uccauggacc aggcuc 46 <210> 103 <211> 24 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 103 ttaaactctc catggaccag gctc 24 <210> 104 <211> 46 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 104 agacaugugu ccucagugac acgcccauac uggggaccaa ggaagu 46 <210> 105 <211> 24 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 105 gcccatactg gggaccaagg aagt 24 <210> 106 <211> 46 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 106 agacaugugu ccucagugac acgccguaac ccuucguggg uagaga 46 <210> 107 <211> 24 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 107 gccgtaaccc ttcgtgggta gaga 24 <210> 108 <211> 36 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 108 uuuuaacaac acucaggcau guguccacag ugacac 36 <210> 109 <211> 36 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 109 uugaacggau acucagacau guguuuccag ugacac 36 <210> 110 <211> 36 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 110 ugcccucaau agucagaugu guguccacag ugacac 36 <210> 111 <211> 36 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 111 ucucaaugau acuuagauac guguccucag ugacac 36 <210> 112 <211> 36 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 112 ucucaaugau acucagacau guguccccag ugacac 36 <210> 113 <211> 36 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 113 ucucaaugau acuaagacau guguccucag ugacac 36 <210> 114 <211> 36 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 114 ucucaacuau acucagacau guguccucag ugacac 36 <210> 115 <211> 36 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 115 ucucaacgau acucagacau guguccucag ugacac 36 <210> 116 <211> 36 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 116 ucucaacgau acuaagauau guguccucag cgacac 36 <210> 117 <211> 36 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 117 ucucaacgau acuaagauau guguccccag ugacac 36 <210> 118 <211> 36 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 118 ucucaacgau acuaagauau guguccacag ugacac 36 <210> 119 <211> 36 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 119 ucucaacaau acucagacau guguccccag ugacac 36 <210> 120 <211> 36 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 120 ucucaacaau acuaaggcau guguccccag ugaccc 36 <210> 121 <211> 36 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 121 ucucaaagau acucagacac guguccccag ugacac 36 <210> 122 <211> 36 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 122 ucucaaaaau acucagacau guguccucag ugacac 36 <210> 123 <211> 36 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 123 gcgaaacaac agucagacau guguccccag ugacac 36 <210> 124 <211> 36 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 124 ccucaacgau auuaagacau guguccgcag ugacac 36 <210> 125 <211> 22 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <220> <221> Característica misc <222> (3)..(3) <223> n es a o g <220> <221> Característica misc <222> (4)..(4) <223> n es c o u <220> <221> Característica misc <222> (5)..(5) <223> n es a o g <220> <221> Característica misc <222> (6)..(6) <223> n es u o c <220> <221> Característica misc <222> (11)..(11) <223> n es c o u <220> <221> Característica misc <222> (12)..(12) <223> n es c o u <220> <221> Característica misc <222> (13)..(13) <223> n es u, a, c o g <220> <221> Característica misc <222> (17)..(17) <223> n es u o c <220> <221> Característica misc <222> (21)..(21) <223> n es a o c <400> 125 agnnnngugu nnncagngac nc 22 <210> 126 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 126 ctcattcttc ccttaggggt 20 <210> 127 <211> 42 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 127 agacaugugu ccucagugac accucauucu ucccuuaggg gu 42 <210> 128 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 128 ccccccaagt ccctcacctc 20 <210> 129 <211> 42 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 129 agacaugugu ccucagugac acccccccaa gucccucacc uc 42 <210> 130 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 130 accaggtcgt ggccgcctct 20 <210> 131 <211> 42 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 131 agacaugugu ccucagugac acaccagguc guggccgccu cu 42 <210> 132 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 132 taggcctgca tcatcaccgt 20 <210> 133 <211> 42 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 133 agacaugugu ccucagugac acuaggccug caucaucacc gu 42 <210> 134 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 134 actggccctg gctttggcag 20 <210> 135 <211> 42 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 135 agacaugugu ccucagugac acacuggccc uggcuuuggc ag 42 <210> 136 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 136 tagcctctcc cgctctggtt 20 <210> 137 <211> 42 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 137 agacaugugu ccucagugac acuagccucu cccgcucugg uu 42 <210> 138 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 138 tagccgaagg ccccagcttt 20 <210> 139 <211> 42 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 139 agacaugugu ccucagugac acuagccgaa ggccccagcu uu 42 <210> 140 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 140 gcgggtatgg gaagggcttt 20 <210> 141 <211> 42 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 141 agacaugugu ccucagugac acgcggguau gggaagggcu uu 42 <210> 142 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 142 acacgggcca ccgtttctca 20 <210> 143 <211> 42 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 143 agacaugugu ccucagugac acacacgggc caccguuucu ca 42 <210> 144 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 144 accccccaag tccctcacct 20 <210> 145 <211> 42 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 145 agacaugugu ccucagugac acacccccca agucccucac cu 42 <210> 146 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 146 ggtgttcacc aggtcgtggc 20 <210> 147 <211> 42 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 147 agacaugugu ccucagugac acgguguuca ccaggucgug gc 42 <210> 148 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 148 ggcctgcatc atcaccgttt 20 <210> 149 <211> 42 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 149 agacaugugu ccucagugac acggccugca ucaucaccgu uu 42 <210> 150 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 150 gccctggctt tggcagcctg 20 <210> 151 <211> 42 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 151 agacaugugu ccucagugac acgcccuggc uuuggcagcc ug 42 <210> 152 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 152 gcctctcccg ctctggttca 20 <210> 153 <211> 42 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 153 agacaugugu ccucagugac acgccucucc cgcucugguu ca 42 <210> 154 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 154 attatagccg aaggccccag 20 <210> 155 <211> 42 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 155 agacaugugu ccucagugac acauuauagc cgaaggcccc ag 42 <210> 156 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 156 gtgcagaggg tgggccgggg 20 <210> 157 <211> 42 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 157 agacaugugu ccucagugac acgugcagag ggugggccgg gg 42 <210> 158 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 158 tgctgagaac cacccagggt 20 <210> 159 <211> 42 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 159 agacaugugu ccucagugac acugcugaga accacccagg gu 42 <210> 160 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 160 ggtgccctag gaagctgcct 20 <210> 161 <211> 42 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 161 agacaugugu ccucagugac acggugcccu aggaagcugc cu 42 <210> 162 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 162 atgcccaaag gtcagatgat 20 <210> 163 <211> 42 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 163 agacaugugu ccucagugac acaugcccaa aggucagaug au 42 <210> 164 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 164 ggggaggcct ggagtcatgg 20 <210> 165 <211> 42 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 165 agacaugugu ccucagugac acggggaggc cuggagucau gg 42 <210> 166 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 166 gcaccactgt agtttagtga 20 <210> 167 <211> 42 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 167 agacaugugu ccucagugac acgcaccacu guaguuuagu ga 42 <210> 168 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 168 tttgagccag tgttgctagt 20 <210> 169 <211> 42 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 169 agacaugugu ccucagugac acuuugagcc aguguugcua gu 42 <210> 170 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 170 ctttagcaag ggactattca 20 <210> 171 <211> 42 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 171 agacaugugu ccucagugac accuuuagca agggacuauu ca 42 <210> 172 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 172 agcaatctac cctggtcctc 20 <210> 173 <211> 42 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 173 agacaugugu ccucagugac acagcaaucu acccuggucc uc 42 <210> 174 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 174 agaaccaccc agggtccagg 20 <210> 175 <211> 42 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 175 agacaugugu ccucagugac acagaaccac ccagggucca gg 42 <210> 176 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 176 gggtgcccta ggaagctgcc 20 <210> 177 <211> 42 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 177 agacaugugu ccucagugac acgggugccc uaggaagcug cc 42 <210> 178 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 178 agatgatagc ataggtacac 20 <210> 179 <211> 42 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 179 agacaugugu ccucagugac acagaugaua gcauagguac ac 42 <210> 180 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 180 actccaggcc tccccaaagc 20 <210> 181 <211> 42 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 181 agacaugugu ccucagugac acacuccagg ccuccccaaa gc 42 <210> 182 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 182 actaaactac agtggtgcct 20 <210> 183 <211> 42 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 183 agacaugugu ccucagugac acacuaaacu acaguggugc cu 42 <210> 184 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 184 ctttgagcca gtgttgctag 20 <210> 185 <211> 42 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 185 agacaugugu ccucagugac accuuugagc caguguugcu ag 42 <210> 186 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 186 ccttgctaaa gaaacatgtg 20 <210> 187 <211> 42 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 187 agacaugugu ccucagugac acccuugcua aagaaacaug ug 42 <210> 188 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 188 gagcaatcta ccctggtcct 20 <210> 189 <211> 42 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 189 agacaugugu ccucagugac acgagcaauc uacccugguc cu 42 <210> 190 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 190 tgggggtgac cgccggagcg 20 <210> 191 <211> 42 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 191 agacaugugu ccucagugac acugggggug accgccggag cg 42 <210> 192 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 192 tgggctgctt ggggttgtca 20 <210> 193 <211> 42 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 193 agacaugugu ccucagugac acugggcugc uugggguugu ca 42 <210> 194 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 194 tccacacctg gaatcggctt 20 <210> 195 <211> 42 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 195 agacaugugu ccucagugac acuccacacc uggaaucggc uu 42 <210> 196 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 196 gtgtagagag gaaaatgtgg 20 <210> 197 <211> 42 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 197 agacaugugu ccucagugac acguguagag aggaaaaugu gg 42 <210> 198 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 198 ggggctttgt ttgggaagct 20 <210> 199 <211> 42 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 199 agacaugugu ccucagugac acggggcuuu guuugggaag cu 42 <210> 200 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 200 acacttcctt ggtccccagt 20 <210> 201 <211> 42 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 201 agacaugugu ccucagugac acacacuucc uuggucccca gu 42 <210> 202 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 202 gtgggtagag aaggattctg 20 <210> 203 <211> 42 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 203 agacaugugu ccucagugac acguggguag agaaggauuc ug 42 <210> 204 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 204 aaatcctccc ttgacccacc 20 <210> 205 <211> 42 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 205 agacaugugu ccucagugac acaaauccuc ccuugaccca cc 42 <210> 206 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 206 ccaaggggga gggctcacgc 20 <210> 207 <211> 42 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 207 agacaugugu ccucagugac acccaagggg gagggcucac gc 42 <210> 208 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 208 acaaccccaa gcagcccaca 20 <210> 209 <211> 42 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 209 agacaugugu ccucagugac acacaacccc aagcagccca ca 42 <210> 210 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 210 aaagccgatt ccaggtgtgg 20 <210> 211 <211> 42 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 211 agacaugugu ccucagugac acaaagccga uuccaggugu gg 42 <210> 212 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 212 tgtgtagaga ggaaaatgtg 20 <210> 213 <211> 42 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 213 agacaugugu ccucagugac acuguguaga gaggaaaaug ug 42 <210> 214 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 214 atccagcttc ccaaacaaag 20 <210> 215 <211> 42 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 215 agacaugugu ccucagugac acauccagcu ucccaaacaa ag 42 <210> 216 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 216 ctggggacca aggaagtgtc 20 <210> 217 <211> 42 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 217 agacaugugu ccucagugac accuggggac caaggaagug uc 42 <210> 218 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 218 ggtagagaag gattctgtgc 20 <210> 219 <211> 42 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 219 agacaugugu ccucagugac acgguagaga aggauucugu gc 42 <210> 220 <211> 20 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 220 ttcaaatcct cccttgaccc 20 <210> 221 <211> 42 <212> ARN <213> Secuencia artificial <220> <223> Constructo sintético <400> 221 agacaugugu ccucagugac acuucaaauc cucccuugac cc 42 <210> 222 <211> 3222 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 222 atggccagca tctcacgccc ctacgggacc aagctgcggc ctgatgcccg gaaaaaggaa 60 atgctggaca aatttttcaa cactctcacc aagggccaaa gggtatttgc cgatctggcg 120 ctgtgtatat acgggagcct gacactcgag atggccaaga gcctagagcc ggaatctgac 180 agcgagctcg tttgtgccat cgggtggttt agactcgtag acaaaaccat ttggagtaag 240 gatgggataa agcaggagaa tctcgtgaag caatatgagg cctattccgg aaaagaggcg 300 tcagaggtgg tgaagactta cctgaatagc ccctcatccg acaaatacgt atggattgat 360 tgccgacaaa agtttttacg gttccagcgg gaacttggaa cgaggaacct gagcgaagat 420 tttgaatgta tgctgtttga gcagtatatc cggcttacca aaggcgagat tgaaggatac 480 gccgccattt ctaatatgtt tggtaatggc gagaaggagg acagatcaaa gaagaggatg 540 tacgctactc gtatgaagga ctggttggag gcaaatgaaa atattacctg ggagcagtac 600 cgagaagcgc tcaaaaacca gttgaacgca aagaatctgg agcaagtggt ggccaactat 660 aagggcaatg ccggcggcgc cgatccattt ttcaagtata gtttctcgaa ggaaggtatg 720 gtgtccaaga aagagcacgc gcagcagctg gacaagttca aaacagtcct gaagaataaa 780 gcccgcgatt taaatttccc caacaaggag aagctcaagc agtacttaga agctgagatt 840 ggtatcccag ttgatgcaaa cgtatactca cagatgttct ctaacggggt gtcggaggtc 900 caaccaaaaa caacacgaaa catgtccttt agcaatgaga agctagatct gttgactgaa 960 ctgaaggact taaacaaggg cgatggattc gaatacgcca gagaagtgct taatggcttc 1020 ttcgatagtg aactccacac tacagaagat aaattcaaca ttactagtcg gtaccttggt 1080 ggggacaaat ccaacaggct cagcaagttg tataagattt ggaagaagga gggggttgat 1140 tgtgaagaag gaattcagca gttctgcgag gctgtgaagg ataaaatggg ccagatcccc 1200 atccggaatg tcctcaaata tttatggcag tttagggaga ccgtcagtgc cgaggacttc 1260 gaagctgcag caaaggcaaa ccacctagag gagaaaataa gccgagtgaa agctcacccg 1320 attgtgattt ccaacaggta ttgggctttc ggcacaagcg ctctggttgg caacatcatg 1380 ccagctgaca agcgtcacca gggggagtat gccggacaga acttcaaaat gtggctgcgc 1440 gcagagctgc attatgatgg caagaaagcc aaacatcacc tcccgttcta taatgccagg 1500 tttttcgaag aagtctattg ttaccatcca tctgtcgctg aaatcactcc ttttaaaacc 1560 aaacaattcg gctgcgagat cgggaaggat attccggatt atgtctctgt ggctctgaag 1620 gacaatccct acaagaaggc gactaaaagg attctacggg ccatctacaa ccccgttgct 1680 aacactacac gagtggataa aacaaccaat tgctccttca tgatcaaaag agagaacgac 1740 gagtataaac tggtcataaa taggaagatc tcgcgagacc gccctaagag gatagaagtc 1800 ggacgcacca tcatgggcta tgaccgaaac cagaccgcgt ctgacaccta ctggatcggt 1860 cggcttgtgc ctcctgggac cagaggagct tacagaattg gggagtggag tgtgcagtat 1920 atcaaatccg gaccagtgct gtcttccaca cagggtgtta ataactccac aaccgatcag 1980 ctcgtctaca acggtatgcc ttcaagtagc gagcgcttta aggcgtggaa gaaggccaga 2040 atggcattta tccgcaaact catcagacaa ctgaatgatg aggggttaga atcaaaaggg 2100 caggactata ttcctgaaaa tccaagttcc ttcgacgtga ggggggaaac gttgtatgtg 2160 ttcaactcca attaccttaa ggccctggta tcaaaacaca ggaaggctaa gaagcctgtg 2220 gaaggcatcc ttgacgagat cgaagcctgg acctccaaag acaaagattc ctgttcactg 2280 atgcggctct ctagcctgag tgatgcctcc atgcaaggta tagcctcact aaagagcctg 2340 attaactctt actttaataa aaatggttgc aagacaatag aggataaaga aaaatttaac 2400 ccagtcttgt atgcaaaact ggtggaggtc gaacagagac gtacaaacaa acggagcgag 2460 aaagtgggaa gaatcgctgg atctctagag cagctggcgc tgcttaacgg cgtcgaagtg 2520 gttattggag aggcagatct gggagaagtt gagaaaggga agtctaagaa acagaatagc 2580 cgtaacatgg actggtgcgc caagcaggtg gcacagagat tggagtacaa gctggctttt 2640 cacggcatcg gttactttgg cgttaatccc atgtacacga gtcaccagga ccccttcgag 2700 catcgccgtg tagccgacca tatcgtgatg cgtgcaagat ttgaggaagt taacgtagag 2760 aacatcgctg aatggcatgt gagaaacttt agcaattacc tccgcgccga cagcggcacc 2820 ggcctttact acaagcaggc cacgatggac tttttgaagc attatggact ggaggagcac 2880 gccgagggct tggaaaacaa aaaaattaag ttctatgact tcaggaagat tcttgaagac 2940 aaaaacctga cgtctgtgat catacctaaa cgcggagggc gcatttacat ggctacaaac 3000 cctgttactt ccgacagcac acccatcact tacgccggaa aaacctataa tcggtgcaat 3060 gcagacgagg tggcagctgc caatatagtg atctccgtcc tggcaccaag aagtaaaaag 3120 aatagggaac aagacgatat ccccctcata actaaaaagg cagagtcgaa gtctccccca 3180 aaggatcgca aacggtctaa gacctcacag ttgccccaaa ag 3222 <210> 223 <211> 3222 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 223 atggctagca tcagcagacc ctacggcacc aagctgagac ccgacgctag aaagaaggag 60 atgctggaca agtttttcaa taccctgacc aaggggcagc gtgtgttcgc cgacctggcc 120 ctgtgcatct acggcagcct gaccctggag atggccaaga gcctggagcc cgagagcgac 180 agcgaactgg tgtgtgccat cggctggttc agactggtgg ataaaaccat ctggagcaag 240 gacggcatca agcaagagaa cctggtgaag cagtacgagg cctacagcgg caaggaggct 300 agcgaggtgg tgaagaccta cctgaacagc cctagcagcg acaagtacgt gtggatcgac 360 tgcagacaga agttcctgag atttcagaga gagctgggca caagaaacct gagcgaggat 420 ttcgagtgca tgctgttcga gcagtacatc agactgacca agggagagat cgagggctac 480 gccgccatca gcaacatgtt cggcaacggc gagaaggagg accggagcaa gaagagaatg 540 tacgccacaa gaatgaagga ctggctggag gccaacgaga acatcacctg ggagcagtac 600 agagaggccc tgaagaatca gctgaacgcc aagaacctgg agcaagtggt ggccaactac 660 aagggcaacg ccggcggcgc cgaccccttc ttcaagtaca gcttcagcaa ggagggcatg 720 gtgagcaaga aggagcacgc tcagcagctc gataagttca aaaccgtgct gaagaacaag 780 gctagagacc tgaacttccc caacaaggag aagctgaagc agtacctgga ggccgagatc 840 ggcatccccg tggacgccaa cgtgtactct cagatgttca gcaacggcgt gagcgaggtg 900 cagcccaaga ccacaagaaa catgagcttc agcaacgaga agctggacct gctgaccgag 960 ctgaaggacc tgaacaaggg cgacggcttc gagtacgcta gagaggtgct gaacggcttc 1020 ttcgatagcg aactgcatac aaccgaggac aagttcaaca ttacaagcag atacctgggc 1080 ggcgacaaga gcaacagact gagcaagctg tacaagatct ggaagaagga gggcgtggac 1140 tgcgaggagg gcattcagca gttctgcgag gccgtgaagg acaagatggg gcagatcccc 1200 atcagaaacg tgctgaagta cctgtggcag ttcagagaga ccgtgagcgc cgaagacttc 1260 gaggcagccg ccaaagccaa ccacctggag gagaaaatta gcagagtgaa agcccacccc 1320 atcgtgatta gcaatagata ctgggccttc ggcacaagcg ccctggtggg caacatcatg 1380 cccgccgaca agagacacca aggcgagtac gccgggcaga acttcaagat gtggctgaga 1440 gccgagctgc actacgacgg caagaaggcc aagcaccacc tgcccttcta caacgctaga 1500 ttcttcgaag aggtgtactg ctaccaccct agcgtggccg agatcacccc cttcaagacc 1560 aagcagttcg gctgcgagat cggcaaggac atccccgact acgtgagcgt ggccctgaag 1620 gacaacccct acaagaaggc caccaagaga atcctgagag ccatctacaa ccccgtggcc 1680 aacaccacaa gagtcgataa gaccaccaac tgcagcttca tgatcaagag agagaacgac 1740 gagtataagc tggtaatcaa cagaaaaatt tcccgagaca gacccaagag aatcgaggtc 1800 ggcagaacca taatgggcta cgacagaaat cagaccgcta gcgacaccta ctggatcggc 1860 agactggtgc cccccggcac aagaggcgcc tacagaatcg gcgagtggag cgtgcagtac 1920 atcaagagcg gccccgtgct gagcagcacc caaggcgtga acaacagcac caccgatcag 1980 ctggtgtaca acggcatgcc tagcagcagc gagagattca aggcctggaa gaaggctaga 2040 atggccttca tcagaaagct gatcagacag ctgaacgacg agggtctgga gagcaagggc 2100 caagactaca tccccgagaa ccctagcagc ttcgacgtga gaggcgagac cctgtacgtg 2160 ttcaactcca actatctgaa agctctggtg agcaagcaca gaaaggccaa gaagcccgtg 2220 gagggcatcc tggacgagat cgaggcctgg acaagcaagg acaaggacag ctgcagcctg 2280 atgagactga gcagcctgag cgacgctagc atgcaaggca tcgctagcct gaagagcctg 2340 atcaacagct acttcaacaa gaacggctgc aagaccatcg aggacaagga gaagttcaac 2400 cccgtgctgt acgccaagct ggtggaggtg gagcagagaa gaaccaacaa gagaagcgag 2460 aaggtaggaa gaatcgccgg cagcctggag cagctggccc tgctgaacgg cgtggaggtg 2520 gtgatcggcg aggccgacct gggcgaggtg gagaagggca agagcaagaa gcagaacagc 2580 agaaacatgg actggtgcgc caagcaagtg gctcagagac tggagtacaa gctggccttc 2640 cacggcatcg gctacttcgg cgtgaacccc atgtacacaa gccaccaaga ccccttcgag 2700 cacagaagag tggccgacca catcgtgatg agagctagat tcgaggaagt aaacgtggag 2760 aacatcgccg agtggcacgt gagaaacttc agcaactacc tgcgcgcgga cagcggcacc 2820 ggcctgtact acaagcaagc caccatggac ttcctgaagc actacggcct ggaggagcac 2880 gccgagggcc tggagaacaa gaagatcaag ttctacgact tcagaaagat cctggaggac 2940 aagaacctga caagcgtgat catccccaag agaggcggca gaatctacat ggccaccaac 3000 cccgtgacaa gcgacagcac ccccatcacc tacgccggca agacctacaa cagatgcaac 3060 gccgacgagg tggcagccgc gaatatagtg atcagcgtgc tagccccccg aagcaagaag 3120 aacagagagc aagacgacat ccccctgatc accaagaagg ccgagagcaa gagccccccc 3180 aaggacagaa agagaagcaa gacatctcag ctgcctcaga ag 3222 <210> 224 <211> 3222 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 224 atggccagca tcagccggcc ctacggcacc aagctgcggc ccgacgcccg gaagaaggag 60 atgctggaca agttcttcaa caccctgacc aagggccagc gggtgttcgc cgacctggcc 120 ctgtgcatct acggcagcct gaccctggag atggccaaga gcctggagcc cgagagcgac 180 agcgagctgg tgtgcgccat cggctggttc cggctggtgg acaagaccat ctggagcaag 240 gacggcatca agcaggagaa cctggtgaag cagtacgagg cctacagcgg caaggaggcc 300 agcgaggtgg tgaagaccta cctgaacagc cccagcagcg acaagtacgt gtggatcgac 360 tgccggcaga agttcctgcg gttccagcgg gagctgggca cccggaacct gagcgaggac 420 ttcgagtgca tgctgttcga gcagtacatc cggctgacca agggcgagat cgagggctac 480 gccgccatca gcaacatgtt cggcaacggc gagaaggagg accggagcaa gaagcggatg 540 tacgccaccc ggatgaagga ctggctggag gccaacgaga acatcacctg ggagcagtac 600 cgggaggccc tgaagaacca gctgaacgcc aagaacctgg agcaggtggt ggccaactac 660 aagggcaacg ccggcggcgc cgaccccttc ttcaagtaca gcttcagcaa ggagggcatg 720 gtgagcaaga aggagcacgc ccagcagctg gacaagttca agaccgtgct gaagaacaag 780 gcccgggacc tgaacttccc caacaaggag aagctgaagc agtacctgga ggccgagatc 840 ggcatccccg tggacgccaa cgtgtacagc cagatgttca gcaacggcgt gagcgaggtg 900 cagcccaaga ccacccggaa catgagcttc agcaacgaga agctggacct gctgaccgag 960 ctgaaggacc tgaacaaggg cgacggcttc gagtacgccc gggaggtgct gaacggcttc 1020 ttcgacagcg agctgcacac caccgaggac aagttcaaca tcaccagccg gtacctgggc 1080 ggcgacaaga gcaaccggct gagcaagctg tacaagatct ggaagaagga gggcgtggac 1140 tgcgaggagg gcatccagca gttctgcgag gccgtgaagg acaagatggg ccagatcccc 1200 atccggaacg tgctgaagta cctgtggcag ttccgggaga ccgtgagcgc cgaggacttc 1260 gaggccgccg ccaaggccaa ccacctggag gagaagatca gccgggtgaa ggcccacccc 1320 atcgtgatca gcaaccggta ctgggccttc ggcaccagcg ccctggtggg caacatcatg 1380 cccgccgaca agcggcacca gggcgagtac gccggccaga acttcaagat gtggctgcgg 1440 gccgagctgc actacgacgg caagaaggcc aagcaccacc tgcccttcta caacgcccgg 1500 ttcttcgagg aggtgtactg ctaccacccc agcgtggccg agatcacccc cttcaagacc 1560 aagcagttcg gctgcgagat cggcaaggac atccccgact acgtgagcgt ggccctgaag 1620 gacaacccct acaagaaggc caccaagcgg atcctgcggg ccatctacaa ccccgtggcc 1680 aacaccaccc gggtggacaa gaccaccaac tgcagcttca tgatcaagcg ggagaacgac 1740 gagtacaagc tggtgatcaa ccggaagatc agccgggacc ggcccaagcg gatcgaggtg 1800 ggccggacca tcatgggcta cgaccggaac cagaccgcca gcgacaccta ctggatcggc 1860 cggctggtgc cccccggcac ccggggcgcc taccggatcg gcgagtggag cgtgcagtac 1920 atcaagagcg gccccgtgct gagcagcacc cagggcgtga acaacagcac caccgaccag 1980 ctggtgtaca acggcatgcc cagcagcagc gagcggttca aggcctggaa gaaggcccgg 2040 atggccttca tccggaagct gatccggcag ctgaacgacg agggcctgga gagcaagggc 2100 caggactaca tccccgagaa ccccagcagc ttcgacgtgc ggggcgagac cctgtacgtg 2160 ttcaacagca actacctgaa ggccctggtg agcaagcacc ggaaggccaa gaagcccgtg 2220 gagggcatcc tggacgagat cgaggcctgg accagcaagg acaaggacag ctgcagcctg 2280 atgcggctga gcagcctgag cgacgccagc atgcagggca tcgccagcct gaagagcctg 2340 atcaacagct acttcaacaa gaacggctgc aagaccatcg aggacaagga gaagttcaac 2400 cccgtgctgt acgccaagct ggtggaggtg gagcagcggc ggaccaacaa gcggagcgag 2460 aaggtgggcc ggatcgccgg cagcctggag cagctggccc tgctgaacgg cgtggaggtg 2520 gtgatcggcg aggccgacct gggcgaggtg gagaagggca agagcaagaa gcagaacagc 2580 cggaacatgg actggtgcgc caagcaggtg gcccagcggc tggagtacaa gctggccttc 2640 cacggcatcg gctacttcgg cgtgaacccc atgtacacca gccaccagga ccccttcgag 2700 caccggcggg tggccgacca catcgtgatg cgggcccggt tcgaggaggt gaacgtggag 2760 aacatcgccg agtggcacgt gcggaacttc agcaactacc tgcgggccga cagcggcacc 2820 ggcctgtact acaagcaggc caccatggac ttcctgaagc actacggcct ggaggagcac 2880 gccgagggcc tggagaacaa gaagatcaag ttctacgact tccggaagat cctggaggac 2940 aagaacctga ccagcgtgat catccccaag cggggcggcc ggatctacat ggccaccaac 3000 cccgtgacca gcgacagcac ccccatcacc tacgccggca agacctacaa ccggtgcaac 3060 gccgacgagg tggccgccgc caacatcgtg atcagcgtgc tggccccccg gagcaagaag 3120 aaccgggagc aggacgacat ccccctgatc accaagaagg ccgagagcaa gagccccccc 3180 aaggaccgga agcggagcaa gaccagccag ctgccccaga ag 3222 <210> 225 <211> 3222 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 225 atggcctcaa taagtcggcc gtacggaaca aaactcagac cagatgccag gaaaaaggaa 60 atgctcgata aattcttcaa taccctgaca aaaggacagc gagtctttgc ggatcttgcg 120 ctctgtattt atggttcact gacactggag atggcgaagt cactcgagcc agaatcagat 180 agtgaacttg tatgtgccat cggctggttt agattggtgg acaagactat atggagcaag 240 gatggcatca agcaagaaaa cttggtcaag cagtacgagg cgtatagtgg taaagaggcg 300 tcagaggtcg tgaaaacgta tcttaacagt cctagttcag acaagtatgt ctggatagac 360 tgtcgccaaa agtttcttcg cttccagcgg gaactcggga cccgaaatct tagtgaggac 420 tttgagtgca tgttgttcga acaatatatc cggctgacta aaggtgagat cgagggatac 480 gccgcaatta gtaacatgtt cggaaacgga gaaaaagagg ataggtctaa gaagcggatg 540 tacgcgacac gaatgaagga ttggctggaa gcaaatgaga acatcacctg ggagcagtat 600 agggaggctt tgaaaaatca actgaatgct aaaaacttgg agcaagtcgt cgcaaattat 660 aagggaaacg caggtggcgc cgacccattc tttaagtata gcttcagtaa ggaaggaatg 720 gtttcaaaga aagagcacgc ccagcagctt gataagttca agaccgtact gaaaaataaa 780 gcgcgggacc tcaatttccc taataaggaa aaattgaagc aatacttgga ggctgagatt 840 ggtataccgg tagatgcaaa tgtctatagc caaatgttta gtaacggtgt gagtgaggta 900 caaccaaaga caacgcgaaa tatgagtttt tcaaatgaga agttggatct tttgacggaa 960 ttgaaggatc ttaacaaggg tgacggcttc gagtacgctc gggaagtctt gaacggtttt 1020 tttgattccg agttgcacac cactgaggac aagtttaaca tcaccagtcg atacctgggg 1080 ggcgataaat ctaacaggct cagtaaactc tacaagatat ggaagaaaga aggagtcgat 1140 tgcgaggaag gtatccaaca gttctgcgaa gctgtgaagg acaaaatggg acaaatcccc 1200 ataaggaatg tgcttaaata tctttggcag ttccgcgaaa cagtcagtgc agaagacttc 1260 gaagctgcag ccaaagccaa ccacctcgaa gagaaaatca gcagagtaaa agcgcatcct 1320 atcgtcataa gtaatcgcta ctgggcgttt ggtacttctg cgctcgttgg gaatatcatg 1380 ccggcagaca aaagacacca aggggagtac gctgggcaaa atttcaaaat gtggctcagg 1440 gcggagctcc attatgatgg aaagaaagca aagcatcatc tgccttttta taacgcgcgg 1500 ttctttgaag aagtctactg ttatcatcca agcgtagctg aaataacgcc ctttaaaact 1560 aaacagtttg ggtgcgaaat agggaaagat attcccgatt atgtgtccgt ggcgctgaaa 1620 gataatccat acaaaaaggc tacgaagcgg atcctgcgcg ccatttataa tcccgtcgcg 1680 aacaccaccc gcgtggataa gacaactaat tgttccttta tgataaagcg cgaaaacgat 1740 gagtataaac tggtcattaa ccgcaagatc tctcgagaca ggccaaaacg catagaggta 1800 ggccgaacca ttatgggtta tgacaggaat cagaccgcct ctgatacata ttggattggg 1860 aggctcgtgc ctcctggtac gaggggcgct taccgcattg gagaatggtc agtgcagtac 1920 atcaagtccg ggcccgtgct tagttctacc caaggggtta ataactcaac tacggaccaa 1980 ctggtgtata acggaatgcc aagtagttcc gaacggttta aagcatggaa gaaggctaga 2040 atggcgttta tacggaaact catacgacaa ttgaatgatg agggacttga gagcaagggt 2100 caagattaca tcccagagaa tccaagctct tttgacgtca ggggtgagac actgtatgtt 2160 ttcaatagca actatttgaa agcactcgtt tctaaacacc ggaaggccaa aaaacctgtg 2220 gaagggatac tcgacgagat tgaagcctgg acttctaaag ataaagatag ttgttccctt 2280 atgcggctct ctagcttgag cgatgcgtca atgcaaggga ttgcctcttt gaaaagtctc 2340 atcaacagct acttcaataa gaacggttgc aagacgatcg aggataagga gaagttcaat 2400 cctgttttgt atgccaaatt ggtagaagtg gagcagagaa gaactaacaa gagatctgag 2460 aaggtaggca ggattgccgg atcccttgaa cagctggcac tccttaatgg ggtcgaagtg 2520 gtcattggtg aagccgacct tggcgaagtc gaaaagggca agtccaagaa gcagaacagt 2580 cgcaacatgg attggtgcgc aaaacaggta gcacaaaggc tcgaatataa gctcgccttc 2640 cacggcattg ggtacttcgg cgttaaccca atgtacacca gtcaccaaga cccctttgag 2700 catagaagag tagcagatca tatagtgatg agggccagat tcgaagaagt gaacgtcgag 2760 aatatcgcag aatggcacgt aaggaatttc tccaattatc tgcgcgctga ttctggtaca 2820 ggcctctact acaagcaggc caccatggat tttctgaaac attacgggct cgaggagcac 2880 gccgaaggtc tggagaataa gaagattaag ttttatgact tccgaaagat tctggaggac 2940 aagaatctta cctccgtgat catcccaaag cgagggggac gcatctatat ggctaccaat 3000 cccgtgacta gcgacagcac tccaataacg tatgccggca aaacctacaa tcgctgtaac 3060 gctgacgagg tggctgccgc caatatagtc atatccgtgc ttgctccccg aagtaaaaag 3120 aatcgggagc aagacgatat tcctttgata acgaaaaaag ccgagagtaa atctccaccc 3180 aaagatcgga agagatcaaa gacctcacaa ctcccgcaaa ag 3222 <210> 226 <211> 3222 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 226 atggcatcta tcagcagacc atacggaacc aaactgagac cagatgctcg gaaaaaggag 60 atgctggaca agttcttcaa caccctgacc aagggacaga gggtgttcgc cgatctggcc 120 ctgtgcatct acggctctct gaccctggaa atggctaagt cgctcgaacc tgagagcgac 180 tccgagctgg tttgtgccat tggatggttc agactggtcg ataagaccat ctggagcaag 240 gacggcatca agcaggagaa cctggtgaaa cagtacgagg cctacagcgg caaggaggcg 300 tctgaagtcg tgaagaccta cctgaacagc ccttctagtg ataagtacgt gtggatcgac 360 tgtagacaga agttcctgag atttcagcgg gaactgggca ccagaaacct gagcgaggac 420 tttgaatgca tgctgttcga gcagtacatc agactgacca agggcgaaat cgagggatat 480 gccgccatta gcaacatgtt cggcaacggc gagaaagagg atagaagcaa gaagagaatg 540 tacgctacac ggatgaagga ctggctggag gccaacgaga acatcacctg ggagcagtat 600 agagaagccc tgaagaacca gctgaacgcc aagaacctcg agcaggtggt ggctaactac 660 aagggcaacg ccggcggcgc cgatcctttc ttcaagtact ccttcagcaa ggagggcatg 720 gtgtccaaga aggagcatgc ccagcaactg gacaaattca agacagtgct gaagaacaag 780 gcccgggatc tgaacttccc caacaaggag aagctcaaac agtacctgga agccgagatc 840 ggcatccccg tcgacgccaa tgtgtactct cagatgttct ccaacggcgt gtctgaagtg 900 caacctaaga caacaagaaa tatgagcttt agcaatgaga agctggacct gctgacagaa 960 ctgaaagatc tgaacaaagg cgatgggttc gaatacgccc gcgaagtgct gaacgggttc 1020 tttgattctg agctgcacac gacagaagat aagttcaata tcacctcgcg gtacctggga 1080 ggcgacaaga gcaatagact gagcaagctg tataagatct ggaagaagga gggcgtggac 1140 tgcgaggagg gcatccaaca gttctgcgag gctgtgaagg ataagatggg ccaaatccct 1200 atcaggaacg ttctcaagta cctgtggcag ttcagagaaa ccgtgagcgc cgaggatttc 1260 gaggccgccg ctaaggccaa ccacctggag gagaagatca gcagagtgaa ggcccaccct 1320 atcgtgatca gcaacagata ctgggccttc ggcacctctg ctctggtcgg aaatatcatg 1380 cccgccgata agcggcacca gggcgagtac gccggccaga acttcaagat gtggctgcgg 1440 gccgaacttc attacgacgg caaaaaggct aaacaccacc tgcctttcta caacgccaga 1500 ttcttcgagg aggtgtactg ctaccacccc agcgtggccg aaatcacacc tttcaagact 1560 aagcagtttg gatgtgaaat cggtaaggat atccccgact acgtcagcgt ggcactgaaa 1620 gacaaccctt acaaaaaagc taccaaacgg attctgagag ccatctacaa ccccgttgcc 1680 aataccacaa gagtggacaa aacaaccaac tgctctttca tgatcaaaag agagaatgac 1740 gaatacaagc tggtaataaa cagaaagatc agcagagacc ggcctaagcg catcgaggtg 1800 ggaagaacca ttatgggcta cgatagaaac cagaccgcca gcgataccta ctggatcggc 1860 agactggtgc cccctggcac aagaggcgcc tacagaatcg gcgaatggtc cgtgcagtac 1920 atcaagagcg gccctgtgct gagctctacc cagggagtga acaacagcac caccgatcag 1980 ctggtgtaca acggtatgcc tagcagcagc gagcggttca aggcatggaa gaaggcccgg 2040 atggccttca tccggaagct gatcagacag ctgaatgacg agggcctgga aagcaaggga 2100 caggactaca tcccagagaa ccctagcagc ttcgacgtgc ggggcgagac gctgtacgtg 2160 ttcaacagca actatctgaa agccctggtc agcaagcaca gaaaggccaa gaagcccgtg 2220 gaaggtatcc tggatgagat cgaggcctgg accagcaagg acaaggacag ctgcagcctg 2280 atgcggctgt cttctctgag cgacgcctcc atgcagggca tcgccagcct gaaaagccta 2340 atcaacagct actttaacaa gaacggctgc aagacaatcg aggacaagga aaagtttaac 2400 cctgtgctgt atgccaaact ggtggaggtg gaacagcggc ggaccaacaa gcggagcgaa 2460 aaagtgggca gaatcgccgg aagcctggag cagcttgccc tgctgaatgg cgtggaagtg 2520 gtgataggcg aggccgacct gggcgaagtg gagaagggca agagcaagaa gcagaactcc 2580 agaaacatgg actggtgcgc caaacaggtg gcccagagac tggaatataa gctggctttt 2640 cacggcatcg gctacttcgg cgttaatcct atgtacacca gccaccagga ccccttcgag 2700 caccggagag tggccgacca catagtgatg agagcccggt tcgaggaagt gaacgtggag 2760 aacatcgccg agtggcacgt gcggaatttt tctaattacc tgagagccga cagcggaaca 2820 ggcctgtact acaagcaggc cacaatggac ttcctgaagc actacggcct ggaagagcac 2880 gccgagggcc tggaaaacaa gaagatcaag ttctacgact tccggaaaat cctggaggat 2940 aagaacctca cctctgtcat catccctaag cgaggcggaa gaatctacat ggccacaaac 3000 ccagtgacca gcgactccac ccctatcacc tacgccggca agacatacaa caggtgtaac 3060 gccgacgaag tggccgctgc caacatcgtg atctctgtgc tggctcctag atcaaagaag 3120 aatagagaac aagacgacat tcccctgatc acaaagaaag cagagagcaa gtccccacct 3180 aaggacagaa agagaagcaa aacctcccag ttgcctcaaa aa 3222 <210> 227 <211> 3222 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 227 atggcctcaa tctctaggcc atatgggacc aaattgagac ctgatgctcg aaaaaaggag 60 atgctggata agtttttcaa cacacttacc aaaggccaga gagtattcgc tgacctggct 120 ctgtgtatct atggctctct gaccctggag atggccaaat ctctggagcc tgagagcgat 180 tccgaacttg tgtgcgctat tggttggttc aggctggttg acaaaacaat ctggtctaaa 240 gatggaatta agcaggaaaa cctggtgaag caatatgagg catattcagg aaaagaggct 300 tccgaggtgg ttaagactta ccttaactca ccatcaagtg ataagtacgt ctggatcgac 360 tgtaggcaga aatttctgcg ctttcagagg gaactcggca ctcgcaatct gtccgaagat 420 tttgagtgca tgctgtttga acagtatatc cgcctcacaa agggcgaaat tgagggttac 480 gctgcaatct ccaacatgtt cggtaatggc gagaaggaag ataggtccaa gaagcgcatg 540 tacgcaacac gaatgaaaga ctggctcgaa gccaacgaga atattacatg ggagcagtac 600 cgggaagctc tgaagaatca actcaatgcg aaaaacctgg aacaggtggt tgcgaattac 660 aaagggaatg ctggtggtgc tgaccccttc tttaaatact ccttctcaaa ggagggtatg 720 gtttcaaaga aagagcatgc tcagcagctc gacaagttca agacagtgtt gaagaataag 780 gccagggatt tgaacttccc aaacaaagaa aagctgaagc aatacctgga agctgagatt 840 ggcattcccg ttgatgctaa cgtgtacagc caaatgttct ccaatggcgt cagtgaggtc 900 caaccgaaaa caacaagaaa catgtccttc tctaacgaga agctcgattt gttgactgaa 960 ttgaaggatc tgaacaaagg agacggcttc gaatatgctc gggaagtgtt gaacggcttt 1020 ttcgacagcg agttgcacac tactgaagat aaattcaaca tcacctctag gtatctcggc 1080 ggggataaga gcaatagact ctctaagttg tacaagatat ggaaaaagga gggcgtggat 1140 tgtgaggagg gaatccagca gttctgtgag gccgtgaagg acaagatggg tcaaatccct 1200 atccggaacg tgctgaagta cctgtggcaa ttccgagaga cggtgtccgc tgaagatttt 1260 gaggccgctg ccaaagcaaa tcacctggag gagaagataa gtagggtgaa ggcacacccc 1320 atcgtgatta gtaacagata ttgggcattt ggaacctcag cgttggttgg aaacattatg 1380 cccgctgata aaagacatca aggagagtat gccgggcaga atttcaaaat gtggctccgc 1440 gcagaactcc actatgacgg gaaaaaggcc aagcatcact tgccatttta caacgcccgc 1500 ttcttcgagg aggtctattg ctaccacccc tccgtcgcag agatcacacc atttaaaacc 1560 aaacagtttg gttgcgagat cgggaaggac attccagatt acgtaagcgt cgcacttaaa 1620 gacaatcctt acaagaaggc gacaaaaagg atcctcagag ccatttataa ccccgtggcc 1680 aacaccacaa gggtggacaa gactaccaac tgttccttca tgattaagcg ggagaacgac 1740 gagtacaaat tggtgattaa ccgcaagatt agcagagaca gaccaaaaag gattgaagta 1800 ggacggacca tcatggggta tgatcggaat cagactgcca gcgatacata ctggatcgga 1860 agattggtgc cacctggtac caggggagca taccggatcg gagagtggtc tgtacagtac 1920 attaaatctg gccccgtgct ttcctctacc cagggcgtta acaactctac tacagaccag 1980 ctcgtttaca acggaatgcc aagttcttcc gaaagattta aggcctggaa aaaggcccgg 2040 atggccttca tccgaaagct gatccgccag ctgaatgacg aagggttgga atctaagggc 2100 caggactaca ttcctgagaa tcctagcagt tttgatgttc gcggagagac gctgtacgtg 2160 tttaattcta actatcttaa agccctcgtg agtaagcata ggaaggctaa aaaaccagtc 2220 gaaggtatat tggacgaaat cgaagcatgg accagcaagg acaaagactc ttgttctctg 2280 atgcgactgt ccagcttgag cgatgcttcc atgcagggca ttgcaagcct gaaaagtctt 2340 attaacagct acttcaacaa aaatgggtgc aaaactatcg aggacaaaga gaagttcaac 2400 cccgtgctct atgcaaagtt ggttgaagtg gagcagcgac ggacaaataa acggagtgag 2460 aaggtcggac ggattgctgg gagcctcgaa caattggccc tgttgaatgg ggtggaggtg 2520 gtgatcgggg aagcagacct tggagaagta gagaagggca aaagtaaaaa gcagaattcc 2580 cgaaatatgg attggtgtgc caaacaggtg gctcagaggc tggagtataa actcgccttt 2640 catggtatcg ggtatttcgg cgtgaatcct atgtacacca gtcatcagga cccgtttgaa 2700 cacaggaggg tcgctgacca tattgtgatg agagccaggt ttgaagaagt caatgtagag 2760 aacatcgccg aatggcacgt gcgaaatttc tcaaactatc tccgggccga ctccggaacg 2820 ggtctttatt acaaacaagc taccatggat ttcctgaagc attacggcct ggaagagcat 2880 gccgagggtc tggaaaacaa gaagataaaa ttctacgatt tccggaagat cctcgaggac 2940 aagaacctga cctccgtcat cattcccaaa cggggtggac gaatctacat ggccacaaat 3000 cccgttacgt ccgacagcac ccctattaca tacgccggca agacctataa ccggtgcaac 3060 gcagatgaag tcgccgctgc aaatatagtt atctccgttc tggccccgag gtccaagaaa 3120 aacagagaac aggacgacat ccccctgatt accaaaaaag ctgagtcaaa atctccgccc 3180 aaagacagga agcggagcaa gacctcccag ctgccccaga ag 3222 <210> 228 <211> 3222 <212> ADN <213> Secuencia artificial <220> <223> Constructo sintético <400> 228 atggcttcaa tttcccgccc ctatggcact aagctgcgcc ctgacgcccg gaaaaaggag 60 atgctggaca agttttttaa tacactgacc aagggacagc gcgtgttcgc cgacctggcc 120 ctgtgtatct acggctctct gacgctggag atggctaagt ccctggagcc cgagtctgac 180 tctgagctgg tgtgcgctat cgggtggttc agactggtgg ataagaccat ctggtctaaa 240 gatggcatta agcaggagaa cctggtgaag caatacgagg cctactcagg gaaggaggcc 300 agcgaagtgg tgaaaaccta cctcaatagc ccaagcagcg acaagtacgt gtggattgat 360 tgccgccaga agtttctccg cttccagcgg gagctgggga ctaggaatct gagcgaagat 420 tttgagtgca tgctgtttga acagtacatc cggctgacta aaggggagat cgagggctat 480 gccgccatca gcaacatgtt tggcaacggg gagaaagagg acagaagtaa aaaacggatg 540 tatgcaaccc gcatgaagga ctggctggaa gccaatgaga acatcacctg ggaacagtat 600 cgcgaagctc tgaagaacca gctgaatgcc aagaatctgg aacaggtggt ggccaattac 660 aaagggaacg ccggcggggc cgatcccttc ttcaaatact ctttcagtaa ggaaggcatg 720 gtgagtaaga aggagcacgc ccagcagctg gataagttta aaacggtgct caagaacaag 780 gccagggacc tgaactttcc caataaggag aagctgaagc agtacctgga ggccgagatc 840 ggcatccccg tggacgcgaa cgtgtactcc cagatgttca gcaatggagt gagcgaggtg 900 cagcccaaga ccacccggaa catgagcttt tctaacgaaa aactggacct gctgaccgag 960 ctgaaggacc tgaataaggg cgacggattt gagtacgcac gggaagtgct gaatggcttc 1020 tttgatagcg agctgcacac cacagaggat aagttcaata tcacctccag gtacctggga 1080 ggcgataaga gcaacagact ctctaagctg tataagattt ggaagaagga aggggtggac 1140 tgcgaggagg gcatccagca gttctgcgag gccgtgaagg acaagatggg ccagatccct 1200 atcagaaacg tgctgaagta tctgtggcag ttccgcgaga ccgtgagcgc cgaggacttt 1260 gaggccgccg ctaaggctaa ccacctggaa gaaaagatct cccgggtgaa agcccaccct 1320 attgtgatct ccaatagata ctgggccttc ggaacttctg ccctggtggg aaatatcatg 1380 cccgccgaca aaagacacca gggggagtat gctggccaga acttcaagat gtggcttagg 1440 gccgagctgc actatgatgg caagaaggcc aagcatcacc tgcctttcta caatgctaga 1500 ttctttgaag aggtgtactg ttaccaccct agcgtggccg agatcacccc ctttaagact 1560 aaacagtttg gctgtgagat tggcaaggac atccccgatt acgtgagcgt ggctctgaag 1620 gacaacccat ataagaaagc caccaaacgc atcctccggg ctatctataa ccccgtggcc 1680 aatactaccc gggtggacaa gacaaccaac tgtagcttca tgatcaaaag agagaacgac 1740 gagtataagc tggtgatcaa cagaaaaatc tcccgggacc gccccaaaag gattgaggtg 1800 ggacgcacca ttatgggata cgataggaac cagaccgcct cagacaccta ctggatcggc 1860 cggctggtgc ctcctggcac taggggggcc taccgcatcg gcgaatggtc cgtgcagtac 1920 attaaatccg gccccgtgct gagctccaca cagggagtga ataattccac caccgaccag 1980 ctggtgtaca acggcatgcc cagcagcagc gagcggttca aggcctggaa gaaggcccgg 2040 atggctttta tacggaagct gatccgccag ctgaacgatg agggcctgga atccaagggc 2100 caggactaca ttcccgaaaa cccttcatcc ttcgacgtga gaggcgaaac tctgtacgtg 2160 ttcaattcca actacctcaa ggccctggtg tctaagcaca ggaaggccaa gaagcccgtg 2220 gaaggcatcc tggacgagat tgaggcatgg accagcaagg acaaggatag ctgttctctc 2280 atgagactga gcagcctgtc cgatgcaagc atgcagggga tcgcctccct gaagagcctg 2340 attaactctt actttaacaa aaatggctgc aagaccatcg aggataaaga gaagtttaat 2400 cccgtgctgt acgcaaaact cgtggaggtg gagcagaggc gcaccaacaa gaggagcgag 2460 aaagtggggc ggatcgctgg aagtctggaa cagctggccc tgctgaacgg cgtggaggtc 2520 gtgattggcg aagcggacct gggcgaggtg gagaagggga agtctaagaa gcagaactct 2580 aggaatatgg actggtgcgc caagcaggtg gcccagagac tggaatacaa actggccttt 2640 catggcattg gatacttcgg cgtgaatcct atgtacacat cacaccagga tccattcgag 2700 cacaggagag tggccgacca catcgtgatg agagccagat tcgaggaggt gaacgtggag 2760 aacatcgcag agtggcacgt gaggaacttt tccaactatc tgcgggccga ctctgggact 2820 ggactgtatt acaagcaggc caccatggac ttcctgaagc actatggcct ggaggagcac 2880 gctgaagggc tggaaaacaa gaaaataaag ttttacgact tccggaagat tctggaggat 2940 aagaacctga cctctgttat catcccaaag cggggcggca gaatctacat ggccaccaac 3000 cccgtgacct ccgacagcac ccccattacc tacgccggaa agacatacaa cagatgcaat 3060 gctgacgagg tggccgccgc caacatagtg atttccgtgc tggccccaag gagtaagaag 3120 aaccgagagc aggacgacat tccactgatt accaagaagg ctgaatccaa atccccacca 3180 aaggacagga agaggagcaa gacctctcag ctgcctcaga ag 3222