LISTADO DE SECUENCIAS <110> Alexion Pharmaceuticals, Inc. <120> POLIPÉPTIDOS DE FOSFATASA ALCALINA Y MÉTODOS PARA SU USO <130> 50694-094WO2 <150> US 63/149,090 <151> 2021-02-12 <160> 6 <170> PatentIn versión 3.5 <210> 1 <211> 507 <212> PRT <213> Homo sapiens <400> 1 Leu Val Pro Glu Lys Glu Lys Asp Pro Lys Tyr Trp Arg Asp Gln Ala 1 5 10 15 Gln Glu Thr Leu Lys Tyr Ala Leu Glu Leu Gln Lys Leu Asn Thr Asn 20 25 30 Val Ala Lys Asn Val Ile Met Phe Leu Gly Asp Gly Met Gly Val Ser 35 40 45 Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Leu His His Asn Pro 50 55 60 Gly Glu Glu Thr Arg Leu Glu Met Asp Lys Phe Pro Phe Val Ala Leu 65 70 75 80 Ser Lys Thr Tyr Asn Thr Asn Ala Gln Val Pro Asp Ser Ala Gly Thr 85 90 95 Ala Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Glu Gly Thr Val Gly 100 105 110 Val Ser Ala Ala Thr Glu Arg Ser Arg Cys Asn Thr Thr Gln Gly Asn 115 120 125 Glu Val Thr Ser Ile Leu Arg Trp Ala Lys Asp Ala Gly Lys Ser Val 130 135 140 Gly Ile Val Thr Thr Thr Arg Val Asn His Ala Thr Pro Ser Ala Ala 145 150 155 160 Tyr Ala His Ser Ala Asp Arg Asp Trp Tyr Ser Asp Asn Glu Met Pro 165 170 175 Pro Glu Ala Leu Ser Gln Gly Cys Lys Asp Ile Ala Tyr Gln Leu Met 180 185 190 His Asn Ile Arg Asp Ile Asp Val Ile Met Gly Gly Gly Arg Lys Tyr 195 200 205 Met Tyr Pro Lys Asn Lys Thr Asp Val Glu Tyr Glu Ser Asp Glu Lys 210 215 220 Ala Arg Gly Thr Arg Leu Asp Gly Leu Asp Leu Val Asp Thr Trp Lys 225 230 235 240 Ser Phe Lys Pro Arg Tyr Lys His Ser His Phe Ile Trp Asn Arg Thr 245 250 255 Glu Leu Leu Thr Leu Asp Pro His Asn Val Asp Tyr Leu Leu Gly Leu 260 265 270 Phe Glu Pro Gly Asp Met Gln Tyr Glu Leu Asn Arg Asn Asn Val Thr 275 280 285 Asp Pro Ser Leu Ser Glu Met Val Val Val Ala Ile Gln Ile Leu Arg 290 295 300 Lys Asn Pro Lys Gly Phe Phe Leu Leu Val Glu Gly Gly Arg Ile Asp 305 310 315 320 His Gly His His Glu Gly Lys Ala Lys Gln Ala Leu His Glu Ala Val 325 330 335 Glu Met Asp Arg Ala Ile Gly Gln Ala Gly Ser Leu Thr Ser Ser Glu 340 345 350 Asp Thr Leu Thr Val Val Thr Ala Asp His Ser His Val Phe Thr Phe 355 360 365 Gly Gly Tyr Thr Pro Arg Gly Asn Ser Ile Phe Gly Leu Ala Pro Met 370 375 380 Leu Ser Asp Thr Asp Lys Lys Pro Phe Thr Ala Ile Leu Tyr Gly Asn 385 390 395 400 Gly Pro Gly Tyr Lys Val Val Gly Gly Glu Arg Glu Asn Val Ser Met 405 410 415 Val Asp Tyr Ala His Asn Asn Tyr Gln Ala Gln Ser Ala Val Pro Leu 420 425 430 Arg His Glu Thr His Gly Gly Glu Asp Val Ala Val Phe Ser Lys Gly 435 440 445 Pro Met Ala His Leu Leu His Gly Val His Glu Gln Asn Tyr Val Pro 450 455 460 His Val Met Ala Tyr Ala Ala Cys Ile Gly Ala Asn Leu Gly His Cys 465 470 475 480 Ala Pro Ala Ser Ser Ala Gly Ser Leu Ala Ala Gly Pro Leu Leu Leu 485 490 495 Ala Leu Ala Leu Tyr Pro Leu Ser Val Leu Phe 500 505 <210> 2 <211> 485 <212> PRT <213> Secuencia artificial <220> <223> Construcción sintética <400> 2 Leu Val Pro Glu Lys Glu Lys Asp Pro Lys Tyr Trp Arg Asp Gln Ala 1 5 10 15 Gln Glu Thr Leu Lys Tyr Ala Leu Glu Leu Gln Lys Leu Asn Thr Asn 20 25 30 Val Ala Lys Asn Val Ile Met Phe Leu Gly Asp Gly Met Gly Val Ser 35 40 45 Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Leu His His Asn Pro 50 55 60 Gly Glu Glu Thr Arg Leu Glu Met Asp Lys Phe Pro Phe Val Ala Leu 65 70 75 80 Ser Lys Thr Tyr Asn Thr Asn Ala Gln Val Pro Asp Ser Ala Gly Thr 85 90 95 Ala Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Met Gly Thr Val Gly 100 105 110 Val Ser Ala Ala Thr Glu Arg Ser Arg Cys Asn Thr Thr Gln Gly Asn 115 120 125 Glu Val Thr Ser Ile Leu Arg Trp Ala Lys Asp Ala Gly Lys Ser Val 130 135 140 Gly Ile Val Thr Thr Thr Arg Val Asn His Ala Thr Pro Ser Ala Ala 145 150 155 160 Tyr Ala His Ser Ala Asp Arg Asp Trp Tyr Ser Asp Asn Glu Met Pro 165 170 175 Pro Glu Ala Leu Ser Gln Gly Cys Lys Asp Ile Ala Tyr Gln Leu Met 180 185 190 His Asn Ile Arg Asp Ile Asp Val Ile Met Gly Gly Gly Arg Lys Tyr 195 200 205 Met Tyr Pro Lys Gln Lys Thr Asp Val Glu Tyr Glu Ser Asp Glu Lys 210 215 220 Ala Arg Gly Thr Arg Leu Asp Gly Leu Asp Leu Val Asp Thr Trp Lys 225 230 235 240 Ser Phe Lys Pro Arg Tyr Lys His Ser His Phe Ile Trp Asn Arg Thr 245 250 255 Glu Leu Leu Thr Leu Asp Pro His Asn Val Asp Tyr Leu Leu Gly Leu 260 265 270 Phe Glu Pro Gly Asp Met Gln Tyr Glu Leu Asn Arg Asn Gln Val Thr 275 280 285 Asp Pro Ser Leu Ser Glu Met Val Val Val Ala Ile Gln Ile Leu Arg 290 295 300 Lys Asn Pro Lys Gly Phe Phe Leu Leu Val Glu Gly Gly Arg Ile Asp 305 310 315 320 His Gly His His Glu Gly Lys Ala Lys Gln Ala Leu His Glu Ala Val 325 330 335 Glu Met Asp Arg Ala Ile Gly Gln Ala Gly Ser Leu Thr Ser Ser Glu 340 345 350 Asp Thr Leu Thr Val Val Thr Ala Asp His Ser His Val Phe Thr Phe 355 360 365 Gly Gly Tyr Thr Pro Arg Gly Asn Ser Ile Phe Gly Leu Ala Pro Met 370 375 380 Leu Ser Asp Thr Asp Lys Lys Pro Phe Thr Ala Ile Leu Tyr Gly Asn 385 390 395 400 Gly Pro Gly Tyr Lys Val Val Gly Gly Glu Arg Glu Asn Val Ser Met 405 410 415 Val Asp Tyr Ala His Asn Asn Tyr Gln Ala Gln Ser Ala Val Pro Leu 420 425 430 Arg His Glu Thr His Gly Gly Glu Asp Val Ala Val Phe Ser Lys Gly 435 440 445 Pro Met Ala His Leu Leu His Gly Val His Glu Gln Asn Tyr Val Pro 450 455 460 His Val Met Ala Tyr Ala Ala Cys Ile Gly Ala Asn Leu Gly His Cys 465 470 475 480 Ala Pro Ala Ser Ser 485 <210> 3 <211> 491 <212> PRT <213> Secuencia artificial <220> <223> Construcción sintética <400> 3 Leu Val Pro Glu Lys Glu Lys Asp Pro Lys Tyr Trp Arg Asp Gln Ala 1 5 10 15 Gln Glu Thr Leu Lys Tyr Ala Leu Glu Leu Gln Lys Leu Asn Thr Asn 20 25 30 Val Ala Lys Asn Val Ile Met Phe Leu Gly Asp Gly Met Gly Val Ser 35 40 45 Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Leu His His Asn Pro 50 55 60 Gly Glu Glu Thr Arg Leu Glu Met Asp Lys Phe Pro Phe Val Ala Leu 65 70 75 80 Ser Lys Thr Tyr Asn Thr Asn Ala Gln Val Pro Asp Ser Ala Gly Thr 85 90 95 Ala Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Met Gly Thr Val Gly 100 105 110 Val Ser Ala Ala Thr Glu Arg Ser Arg Cys Asn Thr Thr Gln Gly Asn 115 120 125 Glu Val Thr Ser Ile Leu Arg Trp Ala Lys Asp Ala Gly Lys Ser Val 130 135 140 Gly Ile Val Thr Thr Thr Arg Val Asn His Ala Thr Pro Ser Ala Ala 145 150 155 160 Tyr Ala His Ser Ala Asp Arg Asp Trp Tyr Ser Asp Asn Glu Met Pro 165 170 175 Pro Glu Ala Leu Ser Gln Gly Cys Lys Asp Ile Ala Tyr Gln Leu Met 180 185 190 His Asn Ile Arg Asp Ile Asp Val Ile Met Gly Gly Gly Arg Lys Tyr 195 200 205 Met Tyr Pro Lys Gln Lys Thr Asp Val Glu Tyr Glu Ser Asp Glu Lys 210 215 220 Ala Arg Gly Thr Arg Leu Asp Gly Leu Asp Leu Val Asp Thr Trp Lys 225 230 235 240 Ser Phe Lys Pro Arg Tyr Lys His Ser His Phe Ile Trp Asn Arg Thr 245 250 255 Glu Leu Leu Thr Leu Asp Pro His Asn Val Asp Tyr Leu Leu Gly Leu 260 265 270 Phe Glu Pro Gly Asp Met Gln Tyr Glu Leu Asn Arg Asn Gln Val Thr 275 280 285 Asp Pro Ser Leu Ser Glu Met Val Val Val Ala Ile Gln Ile Leu Arg 290 295 300 Lys Asn Pro Lys Gly Phe Phe Leu Leu Val Glu Gly Gly Arg Ile Asp 305 310 315 320 His Gly His His Glu Gly Lys Ala Lys Gln Ala Leu His Glu Ala Val 325 330 335 Glu Met Asp Arg Ala Ile Gly Gln Ala Gly Ser Leu Thr Ser Ser Glu 340 345 350 Asp Thr Leu Thr Val Val Thr Ala Asp His Ser His Val Phe Thr Phe 355 360 365 Gly Gly Tyr Thr Pro Arg Gly Asn Ser Ile Phe Gly Leu Ala Pro Met 370 375 380 Leu Ser Asp Thr Asp Lys Lys Pro Phe Thr Ala Ile Leu Tyr Gly Asn 385 390 395 400 Gly Pro Gly Tyr Lys Val Val Gly Gly Glu Arg Glu Asn Val Ser Met 405 410 415 Val Asp Tyr Ala His Asn Asn Tyr Gln Ala Gln Ser Ala Val Pro Leu 420 425 430 Arg His Glu Thr His Gly Gly Glu Asp Val Ala Val Phe Ser Lys Gly 435 440 445 Pro Met Ala His Leu Leu His Gly Val His Glu Gln Asn Tyr Val Pro 450 455 460 His Val Met Ala Tyr Ala Ala Cys Ile Gly Ala Asn Leu Gly His Cys 465 470 475 480 Ala Pro Ala Ser Ser Ala Gly Ser Leu Ala Ala 485 490 <210> 4 <211> 223 <212> PRT <213> Secuencia artificial <220> <223> Construcción sintética <400> 4 Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 1 5 10 15 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 20 25 30 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 35 40 45 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 50 55 60 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 65 70 75 80 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 85 90 95 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 100 105 110 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 115 120 125 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 130 135 140 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 145 150 155 160 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 165 170 175 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 180 185 190 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 195 200 205 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 210 215 220 <210> 5 <211> 724 <212> PRT <213> Secuencia artificial <220> <223> Construcción sintética <400> 5 Leu Val Pro Glu Lys Glu Lys Asp Pro Lys Tyr Trp Arg Asp Gln Ala 1 5 10 15 Gln Glu Thr Leu Lys Tyr Ala Leu Glu Leu Gln Lys Leu Asn Thr Asn 20 25 30 Val Ala Lys Asn Val Ile Met Phe Leu Gly Asp Gly Met Gly Val Ser 35 40 45 Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Leu His His Asn Pro 50 55 60 Gly Glu Glu Thr Arg Leu Glu Met Asp Lys Phe Pro Phe Val Ala Leu 65 70 75 80 Ser Lys Thr Tyr Asn Thr Asn Ala Gln Val Pro Asp Ser Ala Gly Thr 85 90 95 Ala Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Met Gly Thr Val Gly 100 105 110 Val Ser Ala Ala Thr Glu Arg Ser Arg Cys Asn Thr Thr Gln Gly Asn 115 120 125 Glu Val Thr Ser Ile Leu Arg Trp Ala Lys Asp Ala Gly Lys Ser Val 130 135 140 Gly Ile Val Thr Thr Thr Arg Val Asn His Ala Thr Pro Ser Ala Ala 145 150 155 160 Tyr Ala His Ser Ala Asp Arg Asp Trp Tyr Ser Asp Asn Glu Met Pro 165 170 175 Pro Glu Ala Leu Ser Gln Gly Cys Lys Asp Ile Ala Tyr Gln Leu Met 180 185 190 His Asn Ile Arg Asp Ile Asp Val Ile Met Gly Gly Gly Arg Lys Tyr 195 200 205 Met Tyr Pro Lys Gln Lys Thr Asp Val Glu Tyr Glu Ser Asp Glu Lys 210 215 220 Ala Arg Gly Thr Arg Leu Asp Gly Leu Asp Leu Val Asp Thr Trp Lys 225 230 235 240 Ser Phe Lys Pro Arg Tyr Lys His Ser His Phe Ile Trp Asn Arg Thr 245 250 255 Glu Leu Leu Thr Leu Asp Pro His Asn Val Asp Tyr Leu Leu Gly Leu 260 265 270 Phe Glu Pro Gly Asp Met Gln Tyr Glu Leu Asn Arg Asn Gln Val Thr 275 280 285 Asp Pro Ser Leu Ser Glu Met Val Val Val Ala Ile Gln Ile Leu Arg 290 295 300 Lys Asn Pro Lys Gly Phe Phe Leu Leu Val Glu Gly Gly Arg Ile Asp 305 310 315 320 His Gly His His Glu Gly Lys Ala Lys Gln Ala Leu His Glu Ala Val 325 330 335 Glu Met Asp Arg Ala Ile Gly Gln Ala Gly Ser Leu Thr Ser Ser Glu 340 345 350 Asp Thr Leu Thr Val Val Thr Ala Asp His Ser His Val Phe Thr Phe 355 360 365 Gly Gly Tyr Thr Pro Arg Gly Asn Ser Ile Phe Gly Leu Ala Pro Met 370 375 380 Leu Ser Asp Thr Asp Lys Lys Pro Phe Thr Ala Ile Leu Tyr Gly Asn 385 390 395 400 Gly Pro Gly Tyr Lys Val Val Gly Gly Glu Arg Glu Asn Val Ser Met 405 410 415 Val Asp Tyr Ala His Asn Asn Tyr Gln Ala Gln Ser Ala Val Pro Leu 420 425 430 Arg His Glu Thr His Gly Gly Glu Asp Val Ala Val Phe Ser Lys Gly 435 440 445 Pro Met Ala His Leu Leu His Gly Val His Glu Gln Asn Tyr Val Pro 450 455 460 His Val Met Ala Tyr Ala Ala Cys Ile Gly Ala Asn Leu Gly His Cys 465 470 475 480 Ala Pro Ala Ser Ser Ala Gly Ser Leu Ala Ala Val Glu Cys Pro Pro 485 490 495 Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 500 505 510 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 515 520 525 Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 530 535 540 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 545 550 555 560 Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 565 570 575 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 580 585 590 Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 595 600 605 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 610 615 620 Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 625 630 635 640 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 645 650 655 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 660 665 670 Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 675 680 685 Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 690 695 700 Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Asp Asp Asp Asp Asp Asp 705 710 715 720 Asp Asp Asp Asp <210> 6 <211> 726 <212> PRT <213> Secuencia artificial <220> <223> Construcción sintética <400> 6 Leu Val Pro Glu Lys Glu Lys Asp Pro Lys Tyr Trp Arg Asp Gln Ala 1 5 10 15 Gln Glu Thr Leu Lys Tyr Ala Leu Glu Leu Gln Lys Leu Asn Thr Asn 20 25 30 Val Ala Lys Asn Val Ile Met Phe Leu Gly Asp Gly Met Gly Val Ser 35 40 45 Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Leu His His Asn Pro 50 55 60 Gly Glu Glu Thr Arg Leu Glu Met Asp Lys Phe Pro Phe Val Ala Leu 65 70 75 80 Ser Lys Thr Tyr Asn Thr Asn Ala Gln Val Pro Asp Ser Ala Gly Thr 85 90 95 Ala Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Glu Gly Thr Val Gly 100 105 110 Val Ser Ala Ala Thr Glu Arg Ser Arg Cys Asn Thr Thr Gln Gly Asn 115 120 125 Glu Val Thr Ser Ile Leu Arg Trp Ala Lys Asp Ala Gly Lys Ser Val 130 135 140 Gly Ile Val Thr Thr Thr Arg Val Asn His Ala Thr Pro Ser Ala Ala 145 150 155 160 Tyr Ala His Ser Ala Asp Arg Asp Trp Tyr Ser Asp Asn Glu Met Pro 165 170 175 Pro Glu Ala Leu Ser Gln Gly Cys Lys Asp Ile Ala Tyr Gln Leu Met 180 185 190 His Asn Ile Arg Asp Ile Asp Val Ile Met Gly Gly Gly Arg Lys Tyr 195 200 205 Met Tyr Pro Lys Asn Lys Thr Asp Val Glu Tyr Glu Ser Asp Glu Lys 210 215 220 Ala Arg Gly Thr Arg Leu Asp Gly Leu Asp Leu Val Asp Thr Trp Lys 225 230 235 240 Ser Phe Lys Pro Arg Tyr Lys His Ser His Phe Ile Trp Asn Arg Thr 245 250 255 Glu Leu Leu Thr Leu Asp Pro His Asn Val Asp Tyr Leu Leu Gly Leu 260 265 270 Phe Glu Pro Gly Asp Met Gln Tyr Glu Leu Asn Arg Asn Asn Val Thr 275 280 285 Asp Pro Ser Leu Ser Glu Met Val Val Val Ala Ile Gln Ile Leu Arg 290 295 300 Lys Asn Pro Lys Gly Phe Phe Leu Leu Val Glu Gly Gly Arg Ile Asp 305 310 315 320 His Gly His His Glu Gly Lys Ala Lys Gln Ala Leu His Glu Ala Val 325 330 335 Glu Met Asp Arg Ala Ile Gly Gln Ala Gly Ser Leu Thr Ser Ser Glu 340 345 350 Asp Thr Leu Thr Val Val Thr Ala Asp His Ser His Val Phe Thr Phe 355 360 365 Gly Gly Tyr Thr Pro Arg Gly Asn Ser Ile Phe Gly Leu Ala Pro Met 370 375 380 Leu Ser Asp Thr Asp Lys Lys Pro Phe Thr Ala Ile Leu Tyr Gly Asn 385 390 395 400 Gly Pro Gly Tyr Lys Val Val Gly Gly Glu Arg Glu Asn Val Ser Met 405 410 415 Val Asp Tyr Ala His Asn Asn Tyr Gln Ala Gln Ser Ala Val Pro Leu 420 425 430 Arg His Glu Thr His Gly Gly Glu Asp Val Ala Val Phe Ser Lys Gly 435 440 445 Pro Met Ala His Leu Leu His Gly Val His Glu Gln Asn Tyr Val Pro 450 455 460 His Val Met Ala Tyr Ala Ala Cys Ile Gly Ala Asn Leu Gly His Cys 465 470 475 480 Ala Pro Ala Ser Ser Leu Lys Asp Lys Thr His Thr Cys Pro Pro Cys 485 490 495 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 500 505 510 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 515 520 525 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 530 535 540 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 545 550 555 560 Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 565 570 575 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 580 585 590 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 595 600 605 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 610 615 620 Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 625 630 635 640 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 645 650 655 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 660 665 670 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 675 680 685 Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 690 695 700 Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Asp Ile Asp Asp Asp Asp 705 710 715 720 Asp Asp Asp Asp Asp Asp 725