LISTADO DE SECUENCIAS <110> Decibel Therapeutics, Inc. <120> PROMOTORES DE CÉLULA DE SOPORTE VESTIBULAR Y USOS DE ESTOS <130> 51471-010WO2 <150> US 63/184,015 <151> 2021-05-04 <160> 11 <170> PatentIn versión 3.5 <210> 1 <211> 1759 <212> ADN <213> Mus musculus <400> 1 atacacttat gtatatgtgc gatgtcagtg tgtgtgcata taaagtccca aacaagcctg 60 tatgatattg accaacaagg tcaaggcaaa gttttgatac tttcaggtca caacctctcc 120 gcatccctct ctactttgct ctatctgcct gaactcctga ggacatgttt ctactgcaaa 180 tggaaaatcc ttgtcagcca gtgaggaaca aagggactat acatagatga aaacttggct 240 ctctgctggt tcctttgttt gtatgaattt atacaatttg gtaaaactgc caccatgtct 300 tacatggaca gattgagtgt agattctttg aatttttgat gaagaggcgc tgcactggtg 360 atcggaattg cagtctttcc tctgtaggta acctggcttg tttccttaca gtttactttc 420 taggcctcgc ctttctcaca gagtgaagtc ctttgttaag gttcgaattt cccataaacc 480 tgctcaataa tttgtttgtg tttggcttct ttgaaatact acacaaagca atccttgtaa 540 aaggcaaaac tattccgaag gctgagaaag gagctccagg acatagattc aaagtcgctc 600 ttttcaggta gagacagctg ggtaatctta tcttaactgg ctacatttca aggttcccaa 660 ttcaggggct ttcccctctg ggagcagcat tctctccggg tgatgaagag ctttctagtg 720 aggagcaaaa ctttcagaaa accggagggc ccagagcagt ctggtctgtt cacaaaaatt 780 atagcaaaca aaataagccc ggcggattgg gtctctccta cctccagcac caggggagat 840 cagcacttgg ccccaggaca gagacctgag aagtgaggtt tggaagaagc caggaatcca 900 ggaaaggagg caagattgct aaggcaccgg cacagctctg agtcaaaagt tgtcagtctt 960 ctttggctct ggctgcggag ctcaattgct cacagccctg ccctttccta gggctggggc 1020 aaggaattgc tacattcagg attacctggg ggaaaaacca gaggcttgct ttggtccctt 1080 ccggtaattg aaaggactgg ccgtcagcga gggggaggag agagcttccc tccataaatg 1140 gtcccacccc tgggcaaggt ggctcacttt ggcaggtagc aaccggggag tgtgcacctg 1200 ccaccagtca agctcagcca gactgtgaga agaggagagg cgaggcacac caagggatcc 1260 agtgaaccaa cgacagattg aagtgcccga acttcttcaa gtgcagacag aaggaggtag 1320 ggttctggaa gtttctggtg gtgtagggga gtcaggaagg gaaaacaagg agggagagtg 1380 agtcttagtt ttttgctttc tgtagctgtt ccttattttg catatttctt tctcttcaac 1440 tcttttcaag tatgcctgat acgttgttct cacgaagttg acgtgaaaaa caactttcct 1500 gctggtagtt aggaaactta ggagcacctc aacctgtacc ttgagaacac ccagagaatg 1560 ctgctctttg tcgttctcta taccgtgttc atatgctgca gggaaatgca aagaatgtac 1620 tgtccttatc tgaccctggg agcattccat agtcaagcag cagctatcag gttgggaaag 1680 agctcctctc caaggtgtaa cagaaaagga aaatgttgat atttttcttg tttagaaagt 1740 gacagcttca tccgagaac 1759 <210> 2 <211> 6993 <212> ADN <213> Secuencia artificial <220> <223> Construcción sintética <400> 2 ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt 60 ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact 120 aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct 180 aggaagatcg gaattcgccc ttaagctagc ggcgcgccat acacttatgt atatgtgcga 240 tgtcagtgtg tgtgcatata aagtcccaaa caagcctgta tgatattgac caacaaggtc 300 aaggcaaagt tttgatactt tcaggtcaca acctctccgc atccctctct actttgctct 360 atctgcctga actcctgagg acatgtttct actgcaaatg gaaaatcctt gtcagccagt 420 gaggaacaaa gggactatac atagatgaaa acttggctct ctgctggttc ctttgtttgt 480 atgaatttat acaatttggt aaaactgcca ccatgtctta catggacaga ttgagtgtag 540 attctttgaa tttttgatga agaggcgctg cactggtgat cggaattgca gtctttcctc 600 tgtaggtaac ctggcttgtt tccttacagt ttactttcta ggcctcgcct ttctcacaga 660 gtgaagtcct ttgttaaggt tcgaatttcc cataaacctg ctcaataatt tgtttgtgtt 720 tggcttcttt gaaatactac acaaagcaat ccttgtaaaa ggcaaaacta ttccgaaggc 780 tgagaaagga gctccaggac atagattcaa agtcgctctt ttcaggtaga gacagctggg 840 taatcttatc ttaactggct acatttcaag gttcccaatt caggggcttt cccctctggg 900 agcagcattc tctccgggtg atgaagagct ttctagtgag gagcaaaact ttcagaaaac 960 cggagggccc agagcagtct ggtctgttca caaaaattat agcaaacaaa ataagcccgg 1020 cggattgggt ctctcctacc tccagcacca ggggagatca gcacttggcc ccaggacaga 1080 gacctgagaa gtgaggtttg gaagaagcca ggaatccagg aaaggaggca agattgctaa 1140 ggcaccggca cagctctgag tcaaaagttg tcagtcttct ttggctctgg ctgcggagct 1200 caattgctca cagccctgcc ctttcctagg gctggggcaa ggaattgcta cattcaggat 1260 tacctggggg aaaaaccaga ggcttgcttt ggtcccttcc ggtaattgaa aggactggcc 1320 gtcagcgagg gggaggagag agcttccctc cataaatggt cccacccctg ggcaaggtgg 1380 ctcactttgg caggtagcaa ccggggagtg tgcacctgcc accagtcaag ctcagccaga 1440 ctgtgagaag aggagaggcg aggcacacca agggatccag tgaaccaacg acagattgaa 1500 gtgcccgaac ttcttcaagt gcagacagaa ggaggtaggg ttctggaagt ttctggtggt 1560 gtaggggagt caggaaggga aaacaaggag ggagagtgag tcttagtttt ttgctttctg 1620 tagctgttcc ttattttgca tatttctttc tcttcaactc ttttcaagta tgcctgatac 1680 gttgttctca cgaagttgac gtgaaaaaca actttcctgc tggtagttag gaaacttagg 1740 agcacctcaa cctgtacctt gagaacaccc agagaatgct gctctttgtc gttctctata 1800 ccgtgttcat atgctgcagg gaaatgcaaa gaatgtactg tccttatctg accctgggag 1860 cattccatag tcaagcagca gctatcaggt tgggaaagag ctcctctcca aggtgtaaca 1920 gaaaaggaaa atgttgatat ttttcttgtt tagaaagtga cagcttcatc cgagaacgcg 1980 gccgcgccac catgccagag ccagcgaagt ctgctcccgc cccgaaaaag ggctccaaga 2040 aggcggtgac taaggcgcag aagaaaggcg gcaagaagcg caagcgcagc cgcaaggaga 2100 gctattccat ctatgtgtac aaggttctga agcaggtcca ccctgacacc ggcatttcgt 2160 ccaaggccat gggcatcatg aattcgtttg tgaacgacat tttcgagcgc atcgcaggtg 2220 aggcttcccg cctggcgcat tacaacaagc gctcgaccat cacctccagg gagatccaga 2280 cggccgtgcg cctgctgctg cctggggagt tggccaagca cgccgtgtcc gagggtacta 2340 aggccatcac caagtacacc agcgctaagg atccaccggt cgccaccatg gtgagcaagg 2400 gcgaggagct gttcaccggg gtggtgccca tcctggtcga gctggacggc gacgtaaacg 2460 gccacaagtt cagcgtgtcc ggcgagggcg agggcgatgc cacctacggc aagctgaccc 2520 tgaagttcat ctgcaccacc ggcaagctgc ccgtgccctg gcccaccctc gtgaccaccc 2580 tgacctacgg cgtgcagtgc ttcagccgct accccgacca catgaagcag cacgacttct 2640 tcaagtccgc catgcccgaa ggctacgtcc aggagcgcac catcttcttc aaggacgacg 2700 gcaactacaa gacccgcgcc gaggtgaagt tcgagggcga caccctggtg aaccgcatcg 2760 agctgaaggg catcgacttc aaggaggacg gcaacatcct ggggcacaag ctggagtaca 2820 actacaacag ccacaacgtc tatatcatgg ccgacaagca gaagaacggc atcaaggtga 2880 acttcaagat ccgccacaac atcgaggacg gcagcgtgca gctcgccgac cactaccagc 2940 agaacacccc catcggcgac ggccccgtgc tgctgcccga caaccactac ctgagcaccc 3000 agtccgccct gagcaaagac cccaacgaga agcgcgatca catggtcctg ctggagttcg 3060 tgaccgccgc cgggatcact ctcggcatgg acgagctgta caagtaataa gcttggatcc 3120 aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct 3180 ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt 3240 atggctttca ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg 3300 tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc aacccccact 3360 ggttggggca ttgccaccac ctgtcagctc ctttccggga ctttcgcttt ccccctccct 3420 attgccacgg cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg 3480 ttgggcactg acaattccgt ggtgttgtcg gggaaatcat cgtcctttcc ttggctgctc 3540 gcctgtgttg ccacctggat tctgcgcggg acgtccttct gctacgtccc ttcggccctc 3600 aatccagcgg accttccttc ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt 3660 cgaacaattg catcggacac atcttggcgt tttacaacgt cgtgactggg aaaaccctgg 3720 cgttacccaa cttaagatct gcctcgactg tgccttctag ttgccagcca tctgttgttt 3780 gcccctcccc cgtgccttcc ttgaccctgg aaggtgccac tcccactgtc ctttcctaat 3840 aaaatgagga aattgcatcg cattgtctga gtaggtgtca ttctattctg gggggtgggg 3900 tggggcagga cagcaagggg gaggattggg aagacaatag caggcatgct ggggactcga 3960 gttaagggcg aattcccgat aaggatcttc ctagagcatg gctacgtaga taagtagcat 4020 ggcgggttaa tcattaacta caaggaaccc ctagtgatgg agttggccac tccctctctg 4080 cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc 4140 cgggcggcct cagtgagcga gcgagcgcgc agccttaatt aacctaattc actggccgtc 4200 gttttacaac gtcgtgactg ggaaaaccct ggcgttaccc aacttaatcg ccttgcagca 4260 catccccctt tcgccagctg gcgtaatagc gaagaggccc gcaccgatcg cccttcccaa 4320 cagttgcgca gcctgaatgg cgaatgggac gcgccctgta gcggcgcatt aagcgcggcg 4380 ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca gcgccctagc gcccgctcct 4440 ttcgctttct tcccttcctt tctcgccacg ttcgccggct ttccccgtca agctctaaat 4500 cgggggctcc ctttagggtt ccgatttagt gctttacggc acctcgaccc caaaaaactt 4560 gattagggtg atggttcacg tagtgggcca tcgccctgat agacggtttt tcgccctttg 4620 acgttggagt ccacgttctt taatagtgga ctcttgttcc aaactggaac aacactcaac 4680 cctatctcgg tctattcttt tgatttataa gggattttgc cgatttcggc ctattggtta 4740 aaaaatgagc tgatttaaca aaaatttaac gcgaatttta acaaaatatt aacgcttaca 4800 atttaggtgg cacttttcgg ggaaatgtgc gcggaacccc tatttgttta tttttctaaa 4860 tacattcaaa tatgtatccg ctcatgagac aataaccctg ataaatgctt caataatatt 4920 gaaaaaggaa gagtatgagt attcaacatt tccgtgtcgc ccttattccc ttttttgcgg 4980 cattttgcct tcctgttttt gctcacccag aaacgctggt gaaagtaaaa gatgctgaag 5040 atcagttggg tgcacgagtg ggttacatcg aactggatct caacagcggt aagatccttg 5100 agagttttcg ccccgaagaa cgttttccaa tgatgagcac ttttaaagtt ctgctatgtg 5160 gcgcggtatt atcccgtatt gacgccgggc aagagcaact cggtcgccgc atacactatt 5220 ctcagaatga cttggttgag tactcaccag tcacagaaaa gcatcttacg gatggcatga 5280 cagtaagaga attatgcagt gctgccataa ccatgagtga taacactgcg gccaacttac 5340 ttctgacaac gatcggagga ccgaaggagc taaccgcttt tttgcacaac atgggggatc 5400 atgtaactcg ccttgatcgt tgggaaccgg agctgaatga agccatacca aacgacgagc 5460 gtgacaccac gatgcctgta gcaatggcaa caacgttgcg caaactatta actggcgaac 5520 tacttactct agcttcccgg caacaattaa tagactggat ggaggcggat aaagttgcag 5580 gaccacttct gcgctcggcc cttccggctg gctggtttat tgctgataaa tctggagccg 5640 gtgagcgtgg gtctcgcggt atcattgcag cactggggcc agatggtaag ccctcccgta 5700 tcgtagttat ctacacgacg gggagtcagg caactatgga tgaacgaaat agacagatcg 5760 ctgagatagg tgcctcactg attaagcatt ggtaactgtc agaccaagtt tactcatata 5820 tactttagat tgatttaaaa cttcattttt aatttaaaag gatctaggtg aagatccttt 5880 ttgataatct catgaccaaa atcccttaac gtgagttttc gttccactga gcgtcagacc 5940 ccgtagaaaa gatcaaagga tcttcttgag atcctttttt tctgcgcgta atctgctgct 6000 tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt gccggatcaa gagctaccaa 6060 ctctttttcc gaaggtaact ggcttcagca gagcgcagat accaaatact gttcttctag 6120 tgtagccgta gttaggccac cacttcaaga actctgtagc accgcctaca tacctcgctc 6180 tgctaatcct gttaccagtg gctgctgcca gtggcgataa gtcgtgtctt accgggttgg 6240 actcaagacg atagttaccg gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca 6300 cacagcccag cttggagcga acgacctaca ccgaactgag atacctacag cgtgagctat 6360 gagaaagcgc cacgcttccc gaagggagaa aggcggacag gtatccggta agcggcaggg 6420 tcggaacagg agagcgcacg agggagcttc cagggggaaa cgcctggtat ctttatagtc 6480 ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt gtgatgctcg tcaggggggc 6540 ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg gttcctggcc ttttgctggc 6600 cttttgctca catgttcttt cctgcgttat cccctgattc tgtggataac cgtattaccg 6660 cctttgagtg agctgatacc gctcgccgca gccgaacgac cgagcgcagc gagtcagtga 6720 gcgaggaagc ggaagagcgc ccaatacgca aaccgcctct ccccgcgcgt tggccgattc 6780 attaatgcag ctggcacgac aggtttcccg actggaaagc gggcagtgag cgcaacgcaa 6840 ttaatgtgag ttagctcact cattaggcac cccaggcttt acactttatg cttccggctc 6900 gtatgttgtg tggaattgtg agcggataac aatttcacac aggaaacagc tatgaccatg 6960 attacgccag atttaattaa ggccttaatt agg 6993 <210> 3 <211> 834 <212> ADN <213> Homo sapiens <400> 3 aagctgggat gtttcctcat agtttacttt ctaggcctca tctttcttac agagtgtgct 60 cctttgttaa ggttagaatt tcccataaac ctgctcaata atttgtttgt gtttggcttc 120 tttgaaatac tacacaaagc aatccctgta aaaggcaaag ctgtcctgaa ggctgagaaa 180 ggagcctgag acataggctc caagttgctc ttttcaggca gagccagctg ggtaatctta 240 tctcagatgg ctgcttttca aggtgcccaa ttcaggggct tttcctctgg gagcagcatt 300 tgccccaggg aatcaagtgc tttctagtca ggggcaaaac tttgggaaat ctgaggaccc 360 agggtggtat ggtctgttca ggagaatttt ggggaacaga atggccccct tctccctcca 420 gcacttgtac agatcagcac ttggccccag aacagagacc agactgagag gcgaggttag 480 gaggaaacag gggacccagg aaaggcggct agattgcaaa cgtacctaca cagctctgag 540 tcaaaggctg tcagtcatct cggctcagac tgctctgctc tccagcagcc cagccctttc 600 ccagggctgg ggcaggagat tgctacatgt aggcttatct ggggaaaaac cagagcctca 660 ctttagtccc ttccggtaat tgacactact ggacacccag gagggggagg agagagcttc 720 tcttcataaa tgttcccacc cctgggcaag gtggctcact ctggcaggta ggaacagggg 780 agagtgcacc tgctaccagt caagctcagc cagactgcaa gaggaggcga ggcg 834 <210> 4 <211> 354 <212> PRT <213> Homo sapiens <400> 4 Met Ser Arg Leu Leu His Ala Glu Glu Trp Ala Glu Val Lys Glu Leu 1 5 10 15 Gly Asp His His Arg Gln Pro Gln Pro His His Leu Pro Gln Pro Pro 20 25 30 Pro Pro Pro Gln Pro Pro Ala Thr Leu Gln Ala Arg Glu His Pro Val 35 40 45 Tyr Pro Pro Glu Leu Ser Leu Leu Asp Ser Thr Asp Pro Arg Ala Trp 50 55 60 Leu Ala Pro Thr Leu Gln Gly Ile Cys Thr Ala Arg Ala Ala Gln Tyr 65 70 75 80 Leu Leu His Ser Pro Glu Leu Gly Ala Ser Glu Ala Ala Ala Pro Arg 85 90 95 Asp Glu Val Asp Gly Arg Gly Glu Leu Val Arg Arg Ser Ser Gly Gly 100 105 110 Ala Ser Ser Ser Lys Ser Pro Gly Pro Val Lys Val Arg Glu Gln Leu 115 120 125 Cys Lys Leu Lys Gly Gly Val Val Val Asp Glu Leu Gly Cys Ser Arg 130 135 140 Gln Arg Ala Pro Ser Ser Lys Gln Val Asn Gly Val Gln Lys Gln Arg 145 150 155 160 Arg Leu Ala Ala Asn Ala Arg Glu Arg Arg Arg Met His Gly Leu Asn 165 170 175 His Ala Phe Asp Gln Leu Arg Asn Val Ile Pro Ser Phe Asn Asn Asp 180 185 190 Lys Lys Leu Ser Lys Tyr Glu Thr Leu Gln Met Ala Gln Ile Tyr Ile 195 200 205 Asn Ala Leu Ser Glu Leu Leu Gln Thr Pro Ser Gly Gly Glu Gln Pro 210 215 220 Pro Pro Pro Pro Ala Ser Cys Lys Ser Asp His His His Leu Arg Thr 225 230 235 240 Ala Ala Ser Tyr Glu Gly Gly Ala Gly Asn Ala Thr Ala Ala Gly Ala 245 250 255 Gln Gln Ala Ser Gly Gly Ser Gln Arg Pro Thr Pro Pro Gly Ser Cys 260 265 270 Arg Thr Arg Phe Ser Ala Pro Ala Ser Ala Gly Gly Tyr Ser Val Gln 275 280 285 Leu Asp Ala Leu His Phe Ser Thr Phe Glu Asp Ser Ala Leu Thr Ala 290 295 300 Met Met Ala Gln Lys Asn Leu Ser Pro Ser Leu Pro Gly Ser Ile Leu 305 310 315 320 Gln Pro Val Gln Glu Glu Asn Ser Lys Thr Ser Pro Arg Ser His Arg 325 330 335 Ser Asp Gly Glu Phe Ser Pro His Ser His Tyr Ser Asp Ser Asp Glu 340 345 350 Ala Ser <210> 5 <211> 1062 <212> ADN <213> Homo sapiens <400> 5 atgtcccgcc tgctgcatgc agaagagtgg gctgaagtga aggagttggg agaccaccat 60 cgccagcccc agccgcatca tctcccgcaa ccgccgccgc cgccgcagcc acctgcaact 120 ttgcaggcga gagagcatcc cgtctacccg cctgagctgt ccctcctgga cagcaccgac 180 ccacgcgcct ggctggctcc cactttgcag ggcatctgca cggcacgcgc cgcccagtat 240 ttgctacatt ccccggagct gggtgcctca gaggccgctg cgccccggga cgaggtggac 300 ggccgggggg agctggtaag gaggagcagc ggcggtgcca gcagcagcaa gagccccggg 360 ccggtgaaag tgcgggaaca gctgtgcaag ctgaaaggcg gggtggtggt agacgagctg 420 ggctgcagcc gccaacgggc cccttccagc aaacaggtga atggggtgca gaagcagaga 480 cggctagcag ccaacgccag ggagcggcgc aggatgcatg ggctgaacca cgccttcgac 540 cagctgcgca atgttatccc gtcgttcaac aacgacaaga agctgtccaa atatgagacc 600 ctgcagatgg cccaaatcta catcaacgcc ttgtccgagc tgctacaaac gcccagcgga 660 ggggaacagc caccgccgcc tccagcctcc tgcaaaagcg accaccacca ccttcgcacc 720 gcggcctcct atgaaggggg cgcgggcaac gcgaccgcag ctggggctca gcaggcttcc 780 ggagggagcc agcggccgac cccgcccggg agttgccgga ctcgcttctc agccccagct 840 tctgcgggag ggtactcggt gcagctggac gctctgcact tctcgacttt cgaggacagc 900 gccctgacag cgatgatggc gcaaaagaat ttgtctcctt ctctccccgg gagcatcttg 960 cagccagtgc aggaggaaaa cagcaaaact tcgcctcggt cccacagaag cgacggggaa 1020 ttttcccccc attcccatta cagtgactcg gatgaggcaa gt 1062 <210> 6 <211> 351 <212> PRT <213> Mus musculus <400> 6 Met Ser Arg Leu Leu His Ala Glu Glu Trp Ala Glu Val Lys Glu Leu 1 5 10 15 Gly Asp His His Arg His Pro Gln Pro His His Val Pro Pro Leu Thr 20 25 30 Pro Gln Pro Pro Ala Thr Leu Gln Ala Arg Asp Leu Pro Val Tyr Pro 35 40 45 Ala Glu Leu Ser Leu Leu Asp Ser Thr Asp Pro Arg Ala Trp Leu Thr 50 55 60 Pro Thr Leu Gln Gly Leu Cys Thr Ala Arg Ala Ala Gln Tyr Leu Leu 65 70 75 80 His Ser Pro Glu Leu Gly Ala Ser Glu Ala Ala Ala Pro Arg Asp Glu 85 90 95 Ala Asp Ser Gln Gly Glu Leu Val Arg Arg Ser Gly Cys Gly Gly Leu 100 105 110 Ser Lys Ser Pro Gly Pro Val Lys Val Arg Glu Gln Leu Cys Lys Leu 115 120 125 Lys Gly Gly Val Val Val Asp Glu Leu Gly Cys Ser Arg Gln Arg Ala 130 135 140 Pro Ser Ser Lys Gln Val Asn Gly Val Gln Lys Gln Arg Arg Leu Ala 145 150 155 160 Ala Asn Ala Arg Glu Arg Arg Arg Met His Gly Leu Asn His Ala Phe 165 170 175 Asp Gln Leu Arg Asn Val Ile Pro Ser Phe Asn Asn Asp Lys Lys Leu 180 185 190 Ser Lys Tyr Glu Thr Leu Gln Met Ala Gln Ile Tyr Ile Asn Ala Leu 195 200 205 Ser Glu Leu Leu Gln Thr Pro Asn Val Gly Glu Gln Pro Pro Pro Pro 210 215 220 Thr Ala Ser Cys Lys Asn Asp His His His Leu Arg Thr Ala Ser Ser 225 230 235 240 Tyr Glu Gly Gly Ala Gly Ala Ser Ala Val Ala Gly Ala Gln Pro Ala 245 250 255 Pro Gly Gly Gly Pro Arg Pro Thr Pro Pro Gly Pro Cys Arg Thr Arg 260 265 270 Phe Ser Gly Pro Ala Ser Ser Gly Gly Tyr Ser Val Gln Leu Asp Ala 275 280 285 Leu His Phe Pro Ala Phe Glu Asp Arg Ala Leu Thr Ala Met Met Ala 290 295 300 Gln Lys Asp Leu Ser Pro Ser Leu Pro Gly Gly Ile Leu Gln Pro Val 305 310 315 320 Gln Glu Asp Asn Ser Lys Thr Ser Pro Arg Ser His Arg Ser Asp Gly 325 330 335 Glu Phe Ser Pro His Ser His Tyr Ser Asp Ser Asp Glu Ala Ser 340 345 350 <210> 7 <211> 1053 <212> ADN <213> Mus musculus <400> 7 atgtcccgcc tgctgcatgc agaagagtgg gctgaggtaa aagagttggg ggaccaccat 60 cgccatcccc agccgcacca cgtcccgccg ctgacgccac agccacctgc taccctgcag 120 gcgagagacc ttcccgtcta cccggcagaa ctgtccctcc tggatagcac cgacccacgc 180 gcctggctga ctcccacttt gcagggcctc tgcacggcac gcgccgccca gtatctgctg 240 cattctcccg agctgggtgc ctccgaggcc gcggcgcccc gggacgaggc tgacagccag 300 ggtgagctgg taaggagaag cggctgtggc ggcctcagca agagccccgg gcccgtcaaa 360 gtacgggaac agctgtgcaa gctgaagggt ggggttgtag tggacgagct tggctgcagc 420 cgccagcgag ccccttccag caaacaggtg aatggggtac agaagcaaag gaggctggca 480 gcaaacgcaa gggaacggcg caggatgcac gggctgaacc acgccttcga ccagctgcgc 540 aacgttatcc cgtccttcaa caacgacaag aagctgtcca aatatgagac cctacagatg 600 gcccagatct acatcaacgc tctgtcggag ttgctgcaga ctcccaatgt cggagagcaa 660 ccgccgccgc ccacagcttc ctgcaaaaat gaccaccatc accttcgcac cgcctcctcc 720 tatgaaggag gtgcgggcgc ctctgcggta gctggggctc agccagcccc gggagggggc 780 ccgagaccta ccccgcccgg gccttgccgg actcgcttct caggcccagc ttcctctggg 840 ggttactcgg tgcagctgga cgctttgcac ttcccagcct tcgaggacag ggccctaaca 900 gcgatgatgg cacagaagga cctgtcgcct tcgctgcccg ggggcatcct gcagcctgta 960 caggaggaca acagcaaaac atctcccaga tcccacagaa gtgacggaga gttttccccc 1020 cactctcatt acagtgactc tgatgaggcc agt 1053 <210> 8 <211> 548 <212> ADN <213> Secuencia artificial <220> <223> Construcción sintética <400> 8 gatccaatca acctctggat tacaaaattt gtgaaagatt gactggtatt cttaactatg 60 ttgctccttt tacgctatgt ggatacgctg ctttaatgcc tttgtatcat gctattgctt 120 cccgtatggc tttcattttc tcctccttgt ataaatcctg gttgctgtct ctttatgagg 180 agttgtggcc cgttgtcagg caacgtggcg tggtgtgcac tgtgtttgct gacgcaaccc 240 ccactggttg gggcattgcc accacctgtc agctcctttc cgggactttc gctttccccc 300 tccctattgc cacggcggaa ctcatcgccg cctgccttgc ccgctgctgg acaggggctc 360 ggctgttggg cactgacaat tccgtggtgt tgtcggggaa atcatcgtcc tttccttggc 420 tgctcgcctg tgttgccacc tggattctgc gcgggacgtc cttctgctac gtcccttcgg 480 ccctcaatcc agcggacctt ccttcccgcg gcctgctgcc ggctctgcgg cctcttccgc 540 gtcttcga 548 <210> 9 <211> 425 <212> ADN <213> Secuencia artificial <220> <223> Construcción sintética <400> 9 aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct 60 ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt 120 atggctttca ttttctcctc cttgtataaa tcctggttag ttcttgccac ggcggaactc 180 atcgccgcct gccttgcccg ctgctggaca ggggctcggc tgttgggcac tgacaattcc 240 gtggtgttta tttgtgaaat ttgtgatgct attgctttat ttgtaaccat ctagctttat 300 ttgtgaaatt tgtgatgcta ttgctttatt tgtaaccatt ataagctgca ataaacaagt 360 taacaacaac aattgcattc attttatgtt tcaggttcag ggggagatgt gggaggtttt 420 ttaaa 425 <210> 10 <211> 6818 <212> ADN <213> Secuencia artificial <220> <223> Construcción sintética <400> 10 ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt 60 ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact 120 aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct 180 aggaagatcg gaattcgccc ttaagctagc ggcgcgccat acacttatgt atatgtgcga 240 tgtcagtgtg tgtgcatata aagtcccaaa caagcctgta tgatattgac caacaaggtc 300 aaggcaaagt tttgatactt tcaggtcaca acctctccgc atccctctct actttgctct 360 atctgcctga actcctgagg acatgtttct actgcaaatg gaaaatcctt gtcagccagt 420 gaggaacaaa gggactatac atagatgaaa acttggctct ctgctggttc ctttgtttgt 480 atgaatttat acaatttggt aaaactgcca ccatgtctta catggacaga ttgagtgtag 540 attctttgaa tttttgatga agaggcgctg cactggtgat cggaattgca gtctttcctc 600 tgtaggtaac ctggcttgtt tccttacagt ttactttcta ggcctcgcct ttctcacaga 660 gtgaagtcct ttgttaaggt tcgaatttcc cataaacctg ctcaataatt tgtttgtgtt 720 tggcttcttt gaaatactac acaaagcaat ccttgtaaaa ggcaaaacta ttccgaaggc 780 tgagaaagga gctccaggac atagattcaa agtcgctctt ttcaggtaga gacagctggg 840 taatcttatc ttaactggct acatttcaag gttcccaatt caggggcttt cccctctggg 900 agcagcattc tctccgggtg atgaagagct ttctagtgag gagcaaaact ttcagaaaac 960 cggagggccc agagcagtct ggtctgttca caaaaattat agcaaacaaa ataagcccgg 1020 cggattgggt ctctcctacc tccagcacca ggggagatca gcacttggcc ccaggacaga 1080 gacctgagaa gtgaggtttg gaagaagcca ggaatccagg aaaggaggca agattgctaa 1140 ggcaccggca cagctctgag tcaaaagttg tcagtcttct ttggctctgg ctgcggagct 1200 caattgctca cagccctgcc ctttcctagg gctggggcaa ggaattgcta cattcaggat 1260 tacctggggg aaaaaccaga ggcttgcttt ggtcccttcc ggtaattgaa aggactggcc 1320 gtcagcgagg gggaggagag agcttccctc cataaatggt cccacccctg ggcaaggtgg 1380 ctcactttgg caggtagcaa ccggggagtg tgcacctgcc accagtcaag ctcagccaga 1440 ctgtgagaag aggagaggcg aggcacacca agggatccag tgaaccaacg acagattgaa 1500 gtgcccgaac ttcttcaagt gcagacagaa ggaggtaggg ttctggaagt ttctggtggt 1560 gtaggggagt caggaaggga aaacaaggag ggagagtgag tcttagtttt ttgctttctg 1620 tagctgttcc ttattttgca tatttctttc tcttcaactc ttttcaagta tgcctgatac 1680 gttgttctca cgaagttgac gtgaaaaaca actttcctgc tggtagttag gaaacttagg 1740 agcacctcaa cctgtacctt gagaacaccc agagaatgct gctctttgtc gttctctata 1800 ccgtgttcat atgctgcagg gaaatgcaaa gaatgtactg tccttatctg accctgggag 1860 cattccatag tcaagcagca gctatcaggt tgggaaagag ctcctctcca aggtgtaaca 1920 gaaaaggaaa atgttgatat ttttcttgtt tagaaagtga cagcttcatc cgagaacgcg 1980 gccgcgccac catgtcccgc ctgctgcatg cagaagagtg ggctgaagtg aaggagttgg 2040 gagaccacca tcgccagccc cagccgcatc atctcccgca accgccgccg ccgccgcagc 2100 cacctgcaac tttgcaggcg agagagcatc ccgtctaccc gcctgagctg tccctcctgg 2160 acagcaccga cccacgcgcc tggctggctc ccactttgca gggcatctgc acggcacgcg 2220 ccgcccagta tttgctacat tccccggagc tgggtgcctc agaggccgct gcgccccggg 2280 acgaggtgga cggccggggg gagctggtaa ggaggagcag cggcggtgcc agcagcagca 2340 agagccccgg gccggtgaaa gtgcgggaac agctgtgcaa gctgaaaggc ggggtggtgg 2400 tagacgagct gggctgcagc cgccaacggg ccccttccag caaacaggtg aatggggtgc 2460 agaagcagag acggctagca gccaacgcca gggagcggcg caggatgcat gggctgaacc 2520 acgccttcga ccagctgcgc aatgttatcc cgtcgttcaa caacgacaag aagctgtcca 2580 aatatgagac cctgcagatg gcccaaatct acatcaacgc cttgtccgag ctgctacaaa 2640 cgcccagcgg aggggaacag ccaccgccgc ctccagcctc ctgcaaaagc gaccaccacc 2700 accttcgcac cgcggcctcc tatgaagggg gcgcgggcaa cgcgaccgca gctggggctc 2760 agcaggcttc cggagggagc cagcggccga ccccgcccgg gagttgccgg actcgcttct 2820 cagccccagc ttctgcggga gggtactcgg tgcagctgga cgctctgcac ttctcgactt 2880 tcgaggacag cgccctgaca gcgatgatgg cgcaaaagaa tttgtctcct tctctccccg 2940 ggagcatctt gcagccagtg caggaggaaa acagcaaaac ttcgcctcgg tcccacagaa 3000 gcgacgggga attttccccc cattcccatt acagtgactc ggatgaggca agttagaagc 3060 ttggatccaa tcaacctctg gattacaaaa tttgtgaaag attgactggt attcttaact 3120 atgttgctcc ttttacgcta tgtggatacg ctgctttaat gcctttgtat catgctattg 3180 cttcccgtat ggctttcatt ttctcctcct tgtataaatc ctggttgctg tctctttatg 3240 aggagttgtg gcccgttgtc aggcaacgtg gcgtggtgtg cactgtgttt gctgacgcaa 3300 cccccactgg ttggggcatt gccaccacct gtcagctcct ttccgggact ttcgctttcc 3360 ccctccctat tgccacggcg gaactcatcg ccgcctgcct tgcccgctgc tggacagggg 3420 ctcggctgtt gggcactgac aattccgtgg tgttgtcggg gaaatcatcg tcctttcctt 3480 ggctgctcgc ctgtgttgcc acctggattc tgcgcgggac gtccttctgc tacgtccctt 3540 cggccctcaa tccagcggac cttccttccc gcggcctgct gccggctctg cggcctcttc 3600 cgcgtcttcg agatctgcct cgactgtgcc ttctagttgc cagccatctg ttgtttgccc 3660 ctcccccgtg ccttccttga ccctggaagg tgccactccc actgtccttt cctaataaaa 3720 tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct attctggggg gtggggtggg 3780 gcaggacagc aagggggagg attgggaaga caatagcagg catgctgggg actcgagtta 3840 agggcgaatt cccgataagg atcttcctag agcatggcta cgtagataag tagcatggcg 3900 ggttaatcat taactacaag gaacccctag tgatggagtt ggccactccc tctctgcgcg 3960 ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg 4020 cggcctcagt gagcgagcga gcgcgcagcc ttaattaacc taattcactg gccgtcgttt 4080 tacaacgtcg tgactgggaa aaccctggcg ttacccaact taatcgcctt gcagcacatc 4140 cccctttcgc cagctggcgt aatagcgaag aggcccgcac cgatcgccct tcccaacagt 4200 tgcgcagcct gaatggcgaa tgggacgcgc cctgtagcgg cgcattaagc gcggcgggtg 4260 tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg 4320 ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg 4380 ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt 4440 agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt 4500 tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta 4560 tctcggtcta ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa 4620 atgagctgat ttaacaaaaa tttaacgcga attttaacaa aatattaacg cttacaattt 4680 aggtggcact tttcggggaa atgtgcgcgg aacccctatt tgtttatttt tctaaataca 4740 ttcaaatatg tatccgctca tgagacaata accctgataa atgcttcaat aatattgaaa 4800 aaggaagagt atgagccata ttcaacggga aacgtcgagg ccgcgattaa attccaacat 4860 ggatgctgat ttatatgggt ataaatgggc tcgcgataat gtcgggcaat caggtgcgac 4920 aatctatcgc ttgtatggga agcccgatgc gccagagttg tttctgaaac atggcaaagg 4980 tagcgttgcc aatgatgtta cagatgagat ggtcagacta aactggctga cggaatttat 5040 gcctcttccg accatcaagc attttatccg tactcctgat gatgcatggt tactcaccac 5100 tgcgatcccc ggaaaaacag cattccaggt attagaagaa tatcctgatt caggtgaaaa 5160 tattgttgat gcgctggcag tgttcctgcg ccggttgcat tcgattcctg tttgtaattg 5220 tccttttaac agcgatcgcg tatttcgtct tgctcaggcg caatcacgaa tgaataacgg 5280 tttggttgat gcgagtgatt ttgatgacga gcgtaatggc tggcctgttg aacaagtctg 5340 gaaagaaatg cataaacttt tgccattctc accggattca gtcgtcactc atggtgattt 5400 ctcacttgat aaccttattt ttgacgaggg gaaattaata ggttgtattg atgttggacg 5460 agtcggaatc gcagaccgat accaggatct tgccatccta tggaactgcc tcggtgagtt 5520 ttctccttca ttacagaaac ggctttttca aaaatatggt attgataatc ctgatatgaa 5580 taaattgcag tttcatttga tgctcgatga gtttttctaa ctgtcagacc aagtttactc 5640 atatatactt tagattgatt taaaacttca tttttaattt aaaaggatct aggtgaagat 5700 cctttttgat aatctcatga ccaaaatccc ttaacgtgag ttttcgttcc actgagcgtc 5760 agaccccgta gaaaagatca aaggatcttc ttgagatcct ttttttctgc gcgtaatctg 5820 ctgcttgcaa acaaaaaaac caccgctacc agcggtggtt tgtttgccgg atcaagagct 5880 accaactctt tttccgaagg taactggctt cagcagagcg cagataccaa atactgttct 5940 tctagtgtag ccgtagttag gccaccactt caagaactct gtagcaccgc ctacatacct 6000 cgctctgcta atcctgttac cagtggctgc tgccagtggc gataagtcgt gtcttaccgg 6060 gttggactca agacgatagt taccggataa ggcgcagcgg tcgggctgaa cggggggttc 6120 gtgcacacag cccagcttgg agcgaacgac ctacaccgaa ctgagatacc tacagcgtga 6180 gctatgagaa agcgccacgc ttcccgaagg gagaaaggcg gacaggtatc cggtaagcgg 6240 cagggtcgga acaggagagc gcacgaggga gcttccaggg ggaaacgcct ggtatcttta 6300 tagtcctgtc gggtttcgcc acctctgact tgagcgtcga tttttgtgat gctcgtcagg 6360 ggggcggagc ctatggaaaa acgccagcaa cgcggccttt ttacggttcc tggccttttg 6420 ctggcctttt gctcacatgt tctttcctgc gttatcccct gattctgtgg ataaccgtat 6480 taccgccttt gagtgagctg ataccgctcg ccgcagccga acgaccgagc gcagcgagtc 6540 agtgagcgag gaagcggaag agcgcccaat acgcaaaccg cctctccccg cgcgttggcc 6600 gattcattaa tgcagctggc acgacaggtt tcccgactgg aaagcgggca gtgagcgcaa 6660 cgcaattaat gtgagttagc tcactcatta ggcaccccag gctttacact ttatgcttcc 6720 ggctcgtatg ttgtgtggaa ttgtgagcgg ataacaattt cacacaggaa acagctatga 6780 ccatgattac gccagattta attaaggcct taattagg 6818 <210> 11 <211> 6809 <212> ADN <213> Secuencia artificial <220> <223> Construcción sintética <400> 11 ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt 60 ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact 120 aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct 180 aggaagatcg gaattcgccc ttaagctagc ggcgcgccat acacttatgt atatgtgcga 240 tgtcagtgtg tgtgcatata aagtcccaaa caagcctgta tgatattgac caacaaggtc 300 aaggcaaagt tttgatactt tcaggtcaca acctctccgc atccctctct actttgctct 360 atctgcctga actcctgagg acatgtttct actgcaaatg gaaaatcctt gtcagccagt 420 gaggaacaaa gggactatac atagatgaaa acttggctct ctgctggttc ctttgtttgt 480 atgaatttat acaatttggt aaaactgcca ccatgtctta catggacaga ttgagtgtag 540 attctttgaa tttttgatga agaggcgctg cactggtgat cggaattgca gtctttcctc 600 tgtaggtaac ctggcttgtt tccttacagt ttactttcta ggcctcgcct ttctcacaga 660 gtgaagtcct ttgttaaggt tcgaatttcc cataaacctg ctcaataatt tgtttgtgtt 720 tggcttcttt gaaatactac acaaagcaat ccttgtaaaa ggcaaaacta ttccgaaggc 780 tgagaaagga gctccaggac atagattcaa agtcgctctt ttcaggtaga gacagctggg 840 taatcttatc ttaactggct acatttcaag gttcccaatt caggggcttt cccctctggg 900 agcagcattc tctccgggtg atgaagagct ttctagtgag gagcaaaact ttcagaaaac 960 cggagggccc agagcagtct ggtctgttca caaaaattat agcaaacaaa ataagcccgg 1020 cggattgggt ctctcctacc tccagcacca ggggagatca gcacttggcc ccaggacaga 1080 gacctgagaa gtgaggtttg gaagaagcca ggaatccagg aaaggaggca agattgctaa 1140 ggcaccggca cagctctgag tcaaaagttg tcagtcttct ttggctctgg ctgcggagct 1200 caattgctca cagccctgcc ctttcctagg gctggggcaa ggaattgcta cattcaggat 1260 tacctggggg aaaaaccaga ggcttgcttt ggtcccttcc ggtaattgaa aggactggcc 1320 gtcagcgagg gggaggagag agcttccctc cataaatggt cccacccctg ggcaaggtgg 1380 ctcactttgg caggtagcaa ccggggagtg tgcacctgcc accagtcaag ctcagccaga 1440 ctgtgagaag aggagaggcg aggcacacca agggatccag tgaaccaacg acagattgaa 1500 gtgcccgaac ttcttcaagt gcagacagaa ggaggtaggg ttctggaagt ttctggtggt 1560 gtaggggagt caggaaggga aaacaaggag ggagagtgag tcttagtttt ttgctttctg 1620 tagctgttcc ttattttgca tatttctttc tcttcaactc ttttcaagta tgcctgatac 1680 gttgttctca cgaagttgac gtgaaaaaca actttcctgc tggtagttag gaaacttagg 1740 agcacctcaa cctgtacctt gagaacaccc agagaatgct gctctttgtc gttctctata 1800 ccgtgttcat atgctgcagg gaaatgcaaa gaatgtactg tccttatctg accctgggag 1860 cattccatag tcaagcagca gctatcaggt tgggaaagag ctcctctcca aggtgtaaca 1920 gaaaaggaaa atgttgatat ttttcttgtt tagaaagtga cagcttcatc cgagaacgcg 1980 gccgcgccac catgtcccgc ctgctgcatg cagaagagtg ggctgaggta aaagagttgg 2040 gggaccacca tcgccatccc cagccgcacc acgtcccgcc gctgacgcca cagccacctg 2100 ctaccctgca ggcgagagac cttcccgtct acccggcaga actgtccctc ctggatagca 2160 ccgacccacg cgcctggctg actcccactt tgcagggcct ctgcacggca cgcgccgccc 2220 agtatctgct gcattctccc gagctgggtg cctccgaggc cgcggcgccc cgggacgagg 2280 ctgacagcca gggtgagctg gtaaggagaa gcggctgtgg cggcctcagc aagagccccg 2340 ggcccgtcaa agtacgggaa cagctgtgca agctgaaggg tggggttgta gtggacgagc 2400 ttggctgcag ccgccagcga gccccttcca gcaaacaggt gaatggggta cagaagcaaa 2460 ggaggctggc agcaaacgca agggaacggc gcaggatgca cgggctgaac cacgccttcg 2520 accagctgcg caacgttatc ccgtccttca acaacgacaa gaagctgtcc aaatatgaga 2580 ccctacagat ggcccagatc tacatcaacg ctctgtcgga gttgctgcag actcccaatg 2640 tcggagagca accgccgccg cccacagctt cctgcaaaaa tgaccaccat caccttcgca 2700 ccgcctcctc ctatgaagga ggtgcgggcg cctctgcggt agctggggct cagccagccc 2760 cgggaggggg cccgagacct accccgcccg ggccttgccg gactcgcttc tcaggcccag 2820 cttcctctgg gggttactcg gtgcagctgg acgctttgca cttcccagcc ttcgaggaca 2880 gggccctaac agcgatgatg gcacagaagg acctgtcgcc ttcgctgccc gggggcatcc 2940 tgcagcctgt acaggaggac aacagcaaaa catctcccag atcccacaga agtgacggag 3000 agttttcccc ccactctcat tacagtgact ctgatgaggc cagttagaag cttggatcca 3060 atcaacctct ggattacaaa atttgtgaaa gattgactgg tattcttaac tatgttgctc 3120 cttttacgct atgtggatac gctgctttaa tgcctttgta tcatgctatt gcttcccgta 3180 tggctttcat tttctcctcc ttgtataaat cctggttgct gtctctttat gaggagttgt 3240 ggcccgttgt caggcaacgt ggcgtggtgt gcactgtgtt tgctgacgca acccccactg 3300 gttggggcat tgccaccacc tgtcagctcc tttccgggac tttcgctttc cccctcccta 3360 ttgccacggc ggaactcatc gccgcctgcc ttgcccgctg ctggacaggg gctcggctgt 3420 tgggcactga caattccgtg gtgttgtcgg ggaaatcatc gtcctttcct tggctgctcg 3480 cctgtgttgc cacctggatt ctgcgcggga cgtccttctg ctacgtccct tcggccctca 3540 atccagcgga ccttccttcc cgcggcctgc tgccggctct gcggcctctt ccgcgtcttc 3600 gagatctgcc tcgactgtgc cttctagttg ccagccatct gttgtttgcc cctcccccgt 3660 gccttccttg accctggaag gtgccactcc cactgtcctt tcctaataaa atgaggaaat 3720 tgcatcgcat tgtctgagta ggtgtcattc tattctgggg ggtggggtgg ggcaggacag 3780 caagggggag gattgggaag acaatagcag gcatgctggg gactcgagtt aagggcgaat 3840 tcccgataag gatcttccta gagcatggct acgtagataa gtagcatggc gggttaatca 3900 ttaactacaa ggaaccccta gtgatggagt tggccactcc ctctctgcgc gctcgctcgc 3960 tcactgaggc cgggcgacca aaggtcgccc gacgcccggg ctttgcccgg gcggcctcag 4020 tgagcgagcg agcgcgcagc cttaattaac ctaattcact ggccgtcgtt ttacaacgtc 4080 gtgactggga aaaccctggc gttacccaac ttaatcgcct tgcagcacat ccccctttcg 4140 ccagctggcg taatagcgaa gaggcccgca ccgatcgccc ttcccaacag ttgcgcagcc 4200 tgaatggcga atgggacgcg ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta 4260 cgcgcagcgt gaccgctaca cttgccagcg ccctagcgcc cgctcctttc gctttcttcc 4320 cttcctttct cgccacgttc gccggctttc cccgtcaagc tctaaatcgg gggctccctt 4380 tagggttccg atttagtgct ttacggcacc tcgaccccaa aaaacttgat tagggtgatg 4440 gttcacgtag tgggccatcg ccctgataga cggtttttcg ccctttgacg ttggagtcca 4500 cgttctttaa tagtggactc ttgttccaaa ctggaacaac actcaaccct atctcggtct 4560 attcttttga tttataaggg attttgccga tttcggccta ttggttaaaa aatgagctga 4620 tttaacaaaa atttaacgcg aattttaaca aaatattaac gcttacaatt taggtggcac 4680 ttttcgggga aatgtgcgcg gaacccctat ttgtttattt ttctaaatac attcaaatat 4740 gtatccgctc atgagacaat aaccctgata aatgcttcaa taatattgaa aaaggaagag 4800 tatgagccat attcaacggg aaacgtcgag gccgcgatta aattccaaca tggatgctga 4860 tttatatggg tataaatggg ctcgcgataa tgtcgggcaa tcaggtgcga caatctatcg 4920 cttgtatggg aagcccgatg cgccagagtt gtttctgaaa catggcaaag gtagcgttgc 4980 caatgatgtt acagatgaga tggtcagact aaactggctg acggaattta tgcctcttcc 5040 gaccatcaag cattttatcc gtactcctga tgatgcatgg ttactcacca ctgcgatccc 5100 cggaaaaaca gcattccagg tattagaaga atatcctgat tcaggtgaaa atattgttga 5160 tgcgctggca gtgttcctgc gccggttgca ttcgattcct gtttgtaatt gtccttttaa 5220 cagcgatcgc gtatttcgtc ttgctcaggc gcaatcacga atgaataacg gtttggttga 5280 tgcgagtgat tttgatgacg agcgtaatgg ctggcctgtt gaacaagtct ggaaagaaat 5340 gcataaactt ttgccattct caccggattc agtcgtcact catggtgatt tctcacttga 5400 taaccttatt tttgacgagg ggaaattaat aggttgtatt gatgttggac gagtcggaat 5460 cgcagaccga taccaggatc ttgccatcct atggaactgc ctcggtgagt tttctccttc 5520 attacagaaa cggctttttc aaaaatatgg tattgataat cctgatatga ataaattgca 5580 gtttcatttg atgctcgatg agtttttcta actgtcagac caagtttact catatatact 5640 ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga tcctttttga 5700 taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt cagaccccgt 5760 agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct gctgcttgca 5820 aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc taccaactct 5880 ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgttc ttctagtgta 5940 gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc tcgctctgct 6000 aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg ggttggactc 6060 aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt cgtgcacaca 6120 gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg agctatgaga 6180 aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg 6240 aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt atagtcctgt 6300 cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag gggggcggag 6360 cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt 6420 tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta ttaccgcctt 6480 tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt cagtgagcga 6540 ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc cgattcatta 6600 atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca acgcaattaa 6660 tgtgagttag ctcactcatt aggcacccca ggctttacac tttatgcttc cggctcgtat 6720 gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg accatgatta 6780 cgccagattt aattaaggcc ttaattagg 6809