LISTADO DE SECUENCIAS <110> Decibel Therapeutics, Inc. <120> COMPOSICIONES Y MÉTODOS PARA EL TRATAMIENTO DE LA PÉRDIDA AUDITIVA NEUROSENSORIAL MEDIANTE EL USO DE SISTEMAS DE VECTORES DUALES DE ESTEREOCILINA <130> 51471-011WO2 <150> US 63/184,737 <151> 2021-05-05 <160> 52 <170> PatentIn versión 3.5 <210> 1 <211> 1140 <212> ADN <213> Mus musculus <400> 1 agcaggtttg ttacagaaac cttagttaag gtttgttgag ggtttttttt ctctctctct 60 ctcttaattg gctgtcccaa tccatccttc tataaataga aaagagagac agggagtgtg 120 tgtggtttca ttactaaggt aaagacactt gagctacaca cacttgatcc ctgaacatga 180 aatctaagag gttgaacgat cacagtttca ggactatata aggtggtgaa agaccatctg 240 cttcgttttt ctgtttgttc ctacaactct ttccctccgc ttgattttaa ctctaaattg 300 gtgagtagct ggtgggctca ccagactccg agatcctctt ctctgcacgc actgtattag 360 acttggcacc cgggaggatt ttcacctctg ctgcatgggc taatcttcca caagggatct 420 gtggtattgc aatctcgggt tgatgcatga cggtgatgtt gtgtttatag catggctaag 480 gtttagctgc ctatgatgat tggttaggga aggataattt ttgctagaag attggacttt 540 agggaaaaaa aaccccactt ttatttgctt ttagaatttt aaaagactgg gccatgtagc 600 tcaggctggt ttggagttca ttatgtagtc aaggatgctc ttggactctt tagcatcctc 660 ctcctcctct ttttcctcct cctccttctt gttcttcttc ttgttcttcc tcttcccctt 720 ctcttccccc ttctctccct cttcctcctc ttcctcctcc ttcttgttct tcttcctctt 780 ccccttctcc tctccccctt gtcctcctct tccttctcct cctcctcctc ttcttctttc 840 tgagtaccaa gattgcaagt gtgcacacga tgaccagctt ggtctttctt tgtctttttt 900 ttttaacttc aattttggag tgaattcaag agcaaccatg tagtcaagag gtggctggag 960 tcttttctgt atctgggttt ggtttagtac tctgccccat cacttaacag gtccttatgg 1020 ccacatctta aaaaaattct agagatacac ggtgtcggtg agtggctgag aatgtgtggt 1080 cttcccattt ctctgtcacc gtggctcaca tcttgtttcc tctgttcggc caggtagaaa 1140 <210> 2 <211> 2500 <212> ADN <213> Homo sapiens <400> 2 ttttaccaca ataattaaaa agaacagtct agcacagtgc tggccatata aaggctcaat 60 aaatgtttgc tgaaagttaa aaaaaaaaaa aaaaaaaaaa aagccaggcg cagtggttca 120 ttcctgtaat cccagcactt taggaggatg aggtgggaga attacttgag cccaggagtt 180 cgagaccagc ctaggcaaca tggcaaaacc ctgtcaaaac cctgtctctc caaaaaatat 240 gcatatttaa aaaattagcc aggcatggtg gtgtgtgcct gtagtaccag ctactcggga 300 gactgaagtg ggaggatcgc ttgagcctgg gaggtcaagg ctgcaatgag ctgagatcgt 360 gccactgcac tccagccggg gcaacagagc aagaccctgt cacaacagaa acaaaatctt 420 gaggtgtcta gtcctggcct cagcctcaga atatttgttt ctgaacatgt tagttttggg 480 ggttggggat gctggtttga tttcctcctt tttgcctttt gagtgtgtgc aatttatggt 540 atagctggga aacgtcaaag tcaagagttt tgtaggaaag tcacgtcact tagccctgtc 600 tcctgtgccg ggtgagacct gtgtgtgcac ttggtgacaa tggctttgag tctgtcaact 660 ccagactgag gtcagcctta cacacccata gttcccaaag ctgaaaacag gcctgcctcc 720 aacggtacct gctaatatca ggggagcctt ttcagcttac agagcaccct gtatgtgttt 780 gtcttagttc aggccaccat ctccacctta ccaggcatct agaaccttct ccacactttg 840 ccaacagggt tcgtttgcag aattgaaatc ttagttaagg tttgttgaag tttgttgttg 900 tttttttttt ttttttacaa ttggctgttc ccacccacat tcccttgaga cataaataga 960 aaaaaaaaaa aaaagaggtt tcatgagtaa gacaagacat ttgagctgca tccacttgat 1020 ccttgaaaag gaaatctaag aggttgtaac tatcactttt tctagcctat ataaggtagg 1080 tcagtaaggt agcaaaaaca catctgttgt tttgctcctt caactctttt tcctgattct 1140 tcctgggggg aaaccgaaaa cggtgagtaa ctggtggaca catcagaccc cagactcttt 1200 tcttcactgc atgcattcat attaggctca ggtgcttaga ctcctgtttt ccggtggctc 1260 tgacacctgg aaggatttta atctctggga gatgggcttt tcatccatct gcttcccacc 1320 tttcaggaca ggtgcatgcc ttcttccaca gaatgtctgc aagcagccca aactgtatcc 1380 tttcccacgt ggaatttgca acattgcatc tctcgggctg ctgtaggaaa atgccagtgc 1440 atgtgtaaca tggtttacgg ctgcctatgc aaatgactga ttatgtcagt ataattttta 1500 taagaaaaca attgaatcct tctttgggtc attttttttt tccatttttg gcatgtattc 1560 aaaagaaggc tctgagacaa aaaaggctgg ggtgttttcc gtatctggtt ttaatttgga 1620 tattctgtcc cgtcacttaa tacaaaacca tgcttatcac attttaaaaa ttctagacag 1680 gcctggctcg gtggcttgca tctgtcatcc cagcactttg tgaggccaag gcaggcagat 1740 cacctgaggt caggagctca agaccagcct ggccaacatg gcaaaacccc gtctctacta 1800 aaaacacaaa aattagccag gcatggtagt gcgcacctgt aatcccagct actgggaagg 1860 cttaggcagg agaatcactt gagcccagga ggcggaggtt gcggtgagcc gagatcacgc 1920 tcttgcactc cagcctgggt gacagagtga gactccgtct taatttaaaa aaaaaaataa 1980 tctagacaca catacagttt cagtgggcct gggaagatgt gtttcccctg gatgtgcaca 2040 ttcctgtttg tggcttatcg cctctcattt attctgtgtg agtaggtaga aaatgagcat 2100 cacggacgtg ctcagtgctg acgacattgc agcagcgctc caggaatgcc gaggtagagg 2160 ggacgtgagg cgggggtggg atttcctcac agctttgcac ctccagcgag tcaacacaaa 2220 atcaaaatgt aggccaggcg gccagacgca gtggctcaca cctgtaatcc cagcactttg 2280 ggaggccgag gcgggtggat cacgaggtca ggagttcgag accagcctgg ccaagatggt 2340 gaaaccccat ctctactaaa aatacaaaaa aattaaccgg gcgtggtggt gggtgcctgt 2400 aatcccagct actcgggagg ctgaggcaga gaattgcttg aacccgggag gcagaagttg 2460 cagtgagctg agatcatgcc actgcactcc agcctgggca 2500 <210> 3 <211> 833 <212> ADN <213> Secuencia artificial <220> <223> Construcción sintética <400> 3 gttcccaaag ctgaaaacag gcctgcctcc aacggtacct gctaatatca ggggagcctt 60 ttcagcttac agagcaccct gtatgtgttt gtcttagttc aggcacctta ccaggcatct 120 agaaccttct ccacactttg ccaacagggt tcgtttgcag aattgaaatc ttagttaagg 180 tttgttgaag tttgttgttg tttttttttt ttttttacaa ttggctgttc ccacccacat 240 tcccttgaga cataaataga aaaaaaaaaa aaaagaggtt tcatgagtaa gacaagacat 300 ttgagctgca tccacttgat ccttgaaaag gaaatctaag aggttgtaac tatcactttt 360 tctagcctat ataaggtagg tcagtaaggt agcaaaaaca catctgttgt tttgctcctt 420 caactctttt tcctgattct tcctgggggg aaaccgaaaa cggtgagtaa ctggtggaca 480 catcagaccc cagactcttt tcttcactgc atgcattcat attaggctca ggtgcttaga 540 ctcctgtttt ccggtttacg gctgcctatg caaatgactg attatgtcag tataattttt 600 ataagaaaac aattgaatcc ttctttgggt catttttttt ttccattttt ggcatgtatg 660 tgcacattcc tgtttgtggc ttatcgcctc tcatttattc tgtgtgagta ggtagaaaat 720 gagcatcacg gacgtgctca gtgctgacga cattgcagca gcgctccagg aatgccgagg 780 tagaggggac gtgaggcggg ggtgggattt cctcacagct ttgcacctcc agc 833 <210> 4 <211> 1775 <212> PRT <213> Homo sapiens <400> 4 Met Ala Leu Ser Leu Trp Pro Leu Leu Leu Leu Leu Leu Leu Leu Leu 1 5 10 15 Leu Leu Ser Phe Ala Val Thr Leu Ala Pro Thr Gly Pro His Ser Leu 20 25 30 Asp Pro Gly Leu Ser Phe Leu Lys Ser Leu Leu Ser Thr Leu Asp Gln 35 40 45 Ala Pro Gln Gly Ser Leu Ser Arg Ser Arg Phe Phe Thr Phe Leu Ala 50 55 60 Asn Ile Ser Ser Ser Phe Glu Pro Gly Arg Met Gly Glu Gly Pro Val 65 70 75 80 Gly Glu Pro Pro Pro Leu Gln Pro Pro Ala Leu Arg Leu His Asp Phe 85 90 95 Leu Val Thr Leu Arg Gly Ser Pro Asp Trp Glu Pro Met Leu Gly Leu 100 105 110 Leu Gly Asp Met Leu Ala Leu Leu Gly Gln Glu Gln Thr Pro Arg Asp 115 120 125 Phe Leu Val His Gln Ala Gly Val Leu Gly Gly Leu Val Glu Val Leu 130 135 140 Leu Gly Ala Leu Val Pro Gly Gly Pro Pro Thr Pro Thr Arg Pro Pro 145 150 155 160 Cys Thr Arg Asp Gly Pro Ser Asp Cys Val Leu Ala Ala Asp Trp Leu 165 170 175 Pro Ser Leu Leu Leu Leu Leu Glu Gly Thr Arg Trp Gln Ala Leu Val 180 185 190 Gln Val Gln Pro Ser Val Asp Pro Thr Asn Ala Thr Gly Leu Asp Gly 195 200 205 Arg Glu Ala Ala Pro His Phe Leu Gln Gly Leu Leu Gly Leu Leu Thr 210 215 220 Pro Thr Gly Glu Leu Gly Ser Lys Glu Ala Leu Trp Gly Gly Leu Leu 225 230 235 240 Arg Thr Val Gly Ala Pro Leu Tyr Ala Ala Phe Gln Glu Gly Leu Leu 245 250 255 Arg Val Thr His Ser Leu Gln Asp Glu Val Phe Ser Ile Leu Gly Gln 260 265 270 Pro Glu Pro Asp Thr Asn Gly Gln Cys Gln Gly Gly Asn Leu Gln Gln 275 280 285 Leu Leu Leu Trp Gly Val Arg His Asn Leu Ser Trp Asp Val Gln Ala 290 295 300 Leu Gly Phe Leu Ser Gly Ser Pro Pro Pro Pro Pro Ala Leu Leu His 305 310 315 320 Cys Leu Ser Thr Gly Val Pro Leu Pro Arg Ala Ser Gln Pro Ser Ala 325 330 335 His Ile Ser Pro Arg Gln Arg Arg Ala Ile Thr Val Glu Ala Leu Cys 340 345 350 Glu Asn His Leu Gly Pro Ala Pro Pro Tyr Ser Ile Ser Asn Phe Ser 355 360 365 Ile His Leu Leu Cys Gln His Thr Lys Pro Ala Thr Pro Gln Pro His 370 375 380 Pro Ser Thr Thr Ala Ile Cys Gln Thr Ala Val Trp Tyr Ala Val Ser 385 390 395 400 Trp Ala Pro Gly Ala Gln Gly Trp Leu Gln Ala Cys His Asp Gln Phe 405 410 415 Pro Asp Glu Phe Leu Asp Ala Ile Cys Ser Asn Leu Ser Phe Ser Ala 420 425 430 Leu Ser Gly Ser Asn Arg Arg Leu Val Lys Arg Leu Cys Ala Gly Leu 435 440 445 Leu Pro Pro Pro Thr Ser Cys Pro Glu Gly Leu Pro Pro Val Pro Leu 450 455 460 Thr Pro Asp Ile Phe Trp Gly Cys Phe Leu Glu Asn Glu Thr Leu Trp 465 470 475 480 Ala Glu Arg Leu Cys Gly Glu Ala Ser Leu Gln Ala Val Pro Pro Ser 485 490 495 Asn Gln Ala Trp Val Gln His Val Cys Gln Gly Pro Thr Pro Asp Val 500 505 510 Thr Ala Ser Pro Pro Cys His Ile Gly Pro Cys Gly Glu Arg Cys Pro 515 520 525 Asp Gly Gly Ser Phe Leu Val Met Val Cys Ala Asn Asp Thr Met Tyr 530 535 540 Glu Val Leu Val Pro Phe Trp Pro Trp Leu Ala Gly Gln Cys Arg Ile 545 550 555 560 Ser Arg Gly Gly Asn Asp Thr Cys Phe Leu Glu Gly Leu Leu Gly Pro 565 570 575 Leu Leu Pro Ser Leu Pro Pro Leu Gly Pro Ser Pro Leu Cys Leu Thr 580 585 590 Pro Gly Pro Phe Leu Leu Gly Met Leu Ser Gln Leu Pro Arg Cys Gln 595 600 605 Ser Ser Val Pro Ala Leu Ala His Pro Thr Arg Leu His Tyr Leu Leu 610 615 620 Arg Leu Leu Thr Phe Leu Leu Gly Pro Gly Ala Gly Gly Ala Glu Ala 625 630 635 640 Gln Gly Met Leu Gly Arg Ala Leu Leu Leu Ser Ser Leu Pro Asp Asn 645 650 655 Cys Ser Phe Trp Asp Ala Phe Arg Pro Glu Gly Arg Arg Ser Val Leu 660 665 670 Arg Thr Ile Gly Glu Tyr Leu Glu Gln Asp Glu Glu Gln Pro Thr Pro 675 680 685 Ser Gly Phe Glu Pro Thr Val Asn Pro Ser Ser Gly Ile Ser Lys Met 690 695 700 Glu Leu Leu Ala Cys Phe Ser Pro Val Leu Trp Asp Leu Leu Gln Arg 705 710 715 720 Glu Lys Ser Val Trp Ala Leu Gln Ile Leu Val Gln Ala Tyr Leu His 725 730 735 Met Pro Pro Glu Asn Leu Gln Gln Leu Val Leu Ser Ala Glu Arg Glu 740 745 750 Ala Ala Gln Gly Phe Leu Thr Leu Met Leu Gln Gly Lys Leu Gln Gly 755 760 765 Lys Leu Gln Val Pro Pro Ser Glu Glu Gln Ala Leu Gly Arg Leu Thr 770 775 780 Ala Leu Leu Leu Gln Arg Tyr Pro Arg Leu Thr Ser Gln Leu Phe Ile 785 790 795 800 Asp Leu Ser Pro Leu Ile Pro Phe Leu Ala Val Ser Asp Leu Met Arg 805 810 815 Phe Pro Pro Ser Leu Leu Ala Asn Asp Ser Val Leu Ala Ala Ile Arg 820 825 830 Asp Tyr Ser Pro Gly Met Arg Pro Glu Gln Lys Glu Ala Leu Ala Lys 835 840 845 Arg Leu Leu Ala Pro Glu Leu Phe Gly Glu Val Pro Ala Trp Pro Gln 850 855 860 Glu Leu Leu Trp Ala Val Leu Pro Leu Leu Pro His Leu Pro Leu Glu 865 870 875 880 Asn Phe Leu Gln Leu Ser Pro His Gln Ile Gln Ala Leu Glu Asp Ser 885 890 895 Trp Pro Ala Ala Gly Leu Gly Pro Gly His Ala Arg His Val Leu Arg 900 905 910 Ser Leu Val Asn Gln Ser Val Gln Asp Gly Glu Glu Gln Val Arg Arg 915 920 925 Leu Gly Pro Leu Ala Cys Phe Leu Ser Pro Glu Glu Leu Gln Ser Leu 930 935 940 Val Pro Leu Ser Asp Pro Thr Gly Pro Val Glu Arg Gly Leu Leu Glu 945 950 955 960 Cys Ala Ala Asn Gly Thr Leu Ser Pro Glu Gly Arg Val Ala Tyr Glu 965 970 975 Leu Leu Gly Val Leu Arg Ser Ser Gly Gly Ala Val Leu Ser Pro Arg 980 985 990 Glu Leu Arg Val Trp Ala Pro Leu Phe Ser Gln Leu Gly Leu Arg Phe 995 1000 1005 Leu Gln Glu Leu Ser Glu Pro Gln Leu Arg Ala Met Leu Pro Val 1010 1015 1020 Leu Gln Gly Thr Ser Val Thr Pro Ala Gln Ala Val Leu Leu Leu 1025 1030 1035 Gly Arg Leu Leu Pro Arg His Asp Leu Ser Leu Glu Glu Leu Cys 1040 1045 1050 Ser Leu His Leu Leu Leu Pro Gly Leu Ser Pro Gln Thr Leu Gln 1055 1060 1065 Ala Ile Pro Arg Arg Val Leu Val Gly Ala Cys Ser Cys Leu Ala 1070 1075 1080 Pro Glu Leu Ser Arg Leu Ser Ala Cys Gln Thr Ala Ala Leu Leu 1085 1090 1095 Gln Thr Phe Arg Val Lys Asp Gly Val Lys Asn Met Gly Thr Thr 1100 1105 1110 Gly Ala Gly Pro Ala Val Cys Ile Pro Gly Gln Pro Ile Pro Thr 1115 1120 1125 Thr Trp Pro Asp Cys Leu Leu Pro Leu Leu Pro Leu Lys Leu Leu 1130 1135 1140 Gln Leu Asp Ser Leu Ala Leu Leu Ala Asn Arg Arg Arg Tyr Trp 1145 1150 1155 Glu Leu Pro Trp Ser Glu Gln Gln Ala Gln Phe Leu Trp Lys Lys 1160 1165 1170 Met Gln Val Pro Thr Asn Leu Thr Leu Arg Asn Leu Gln Ala Leu 1175 1180 1185 Gly Thr Leu Ala Gly Gly Met Ser Cys Glu Phe Leu Gln Gln Ile 1190 1195 1200 Asn Ser Met Val Asp Phe Leu Glu Val Val His Met Ile Tyr Gln 1205 1210 1215 Leu Pro Thr Arg Val Arg Gly Ser Leu Arg Ala Cys Ile Trp Ala 1220 1225 1230 Glu Leu Gln Arg Arg Met Ala Met Pro Glu Pro Glu Trp Thr Thr 1235 1240 1245 Val Gly Pro Glu Leu Asn Gly Leu Asp Ser Lys Leu Leu Leu Asp 1250 1255 1260 Leu Pro Ile Gln Leu Met Asp Arg Leu Ser Asn Glu Ser Ile Met 1265 1270 1275 Leu Val Val Glu Leu Val Gln Arg Ala Pro Glu Gln Leu Leu Ala 1280 1285 1290 Leu Thr Pro Leu His Gln Ala Ala Leu Ala Glu Arg Ala Leu Gln 1295 1300 1305 Asn Leu Ala Pro Lys Glu Thr Pro Val Ser Gly Glu Val Leu Glu 1310 1315 1320 Thr Leu Gly Pro Leu Val Gly Phe Leu Gly Thr Glu Ser Thr Arg 1325 1330 1335 Gln Ile Pro Leu Gln Ile Leu Leu Ser His Leu Ser Gln Leu Gln 1340 1345 1350 Gly Phe Cys Leu Gly Glu Thr Phe Ala Thr Glu Leu Gly Trp Leu 1355 1360 1365 Leu Leu Gln Glu Ser Val Leu Gly Lys Pro Glu Leu Trp Ser Gln 1370 1375 1380 Asp Glu Val Glu Gln Ala Gly Arg Leu Val Phe Thr Leu Ser Thr 1385 1390 1395 Glu Ala Ile Ser Leu Ile Pro Arg Glu Ala Leu Gly Pro Glu Thr 1400 1405 1410 Leu Glu Arg Leu Leu Glu Lys Gln Gln Ser Trp Glu Gln Ser Arg 1415 1420 1425 Val Gly Gln Leu Cys Arg Glu Pro Gln Leu Ala Ala Lys Lys Ala 1430 1435 1440 Ala Leu Val Ala Gly Val Val Arg Pro Ala Ala Glu Asp Leu Pro 1445 1450 1455 Glu Pro Val Pro Asn Cys Ala Asp Val Arg Gly Thr Phe Pro Ala 1460 1465 1470 Ala Trp Ser Ala Thr Gln Ile Ala Glu Met Glu Leu Ser Asp Phe 1475 1480 1485 Glu Asp Cys Leu Thr Leu Phe Ala Gly Asp Pro Gly Leu Gly Pro 1490 1495 1500 Glu Glu Leu Arg Ala Ala Met Gly Lys Ala Lys Gln Leu Trp Gly 1505 1510 1515 Pro Pro Arg Gly Phe Arg Pro Glu Gln Ile Leu Gln Leu Gly Arg 1520 1525 1530 Leu Leu Ile Gly Leu Gly Asp Arg Glu Leu Gln Glu Leu Ile Leu 1535 1540 1545 Val Asp Trp Gly Val Leu Ser Thr Leu Gly Gln Ile Asp Gly Trp 1550 1555 1560 Ser Thr Thr Gln Leu Arg Ile Val Val Ser Ser Phe Leu Arg Gln 1565 1570 1575 Ser Gly Arg His Val Ser His Leu Asp Phe Val His Leu Thr Ala 1580 1585 1590 Leu Gly Tyr Thr Leu Cys Gly Leu Arg Pro Glu Glu Leu Gln His 1595 1600 1605 Ile Ser Ser Trp Glu Phe Ser Gln Ala Ala Leu Phe Leu Gly Thr 1610 1615 1620 Leu His Leu Gln Cys Ser Glu Glu Gln Leu Glu Val Leu Ala His 1625 1630 1635 Leu Leu Val Leu Pro Gly Gly Phe Gly Pro Ile Ser Asn Trp Gly 1640 1645 1650 Pro Glu Ile Phe Thr Glu Ile Gly Thr Ile Ala Ala Gly Ile Pro 1655 1660 1665 Asp Leu Ala Leu Ser Ala Leu Leu Arg Gly Gln Ile Gln Gly Val 1670 1675 1680 Thr Pro Leu Ala Ile Ser Val Ile Pro Pro Pro Lys Phe Ala Val 1685 1690 1695 Val Phe Ser Pro Ile Gln Leu Ser Ser Leu Thr Ser Ala Gln Ala 1700 1705 1710 Val Ala Val Thr Pro Glu Gln Met Ala Phe Leu Ser Pro Glu Gln 1715 1720 1725 Arg Arg Ala Val Ala Trp Ala Gln His Glu Gly Lys Glu Ser Pro 1730 1735 1740 Glu Gln Gln Gly Arg Ser Thr Ala Trp Gly Leu Gln Asp Trp Ser 1745 1750 1755 Arg Pro Ser Trp Ser Leu Val Leu Thr Ile Ser Phe Leu Gly His 1760 1765 1770 Leu Leu 1775 <210> 5 <211> 1809 <212> PRT <213> Mus musculus <400> 5 Met Ala Leu Ser Leu Gln Pro Gln Leu Leu Leu Leu Leu Ser Leu Leu 1 5 10 15 Pro Gln Glu Val Thr Ser Ala Pro Thr Gly Pro Gln Ser Leu Asp Ala 20 25 30 Gly Leu Ser Leu Leu Lys Ser Phe Val Ala Thr Leu Asp Gln Ala Pro 35 40 45 Gln Arg Ser Leu Ser Gln Ser Arg Phe Ser Ala Phe Leu Ala Asn Ile 50 55 60 Ser Ser Ser Phe Gln Leu Gly Arg Met Gly Glu Gly Pro Val Gly Glu 65 70 75 80 Pro Pro Pro Leu Gln Pro Pro Ala Leu Arg Leu His Asp Phe Leu Val 85 90 95 Thr Leu Arg Gly Ser Pro Asp Trp Glu Pro Met Leu Gly Leu Leu Gly 100 105 110 Asp Val Leu Ala Leu Leu Gly Gln Glu Gln Thr Pro Arg Asp Phe Leu 115 120 125 Val His Gln Ala Gly Val Leu Gly Gly Leu Val Glu Ala Leu Leu Gly 130 135 140 Ala Leu Val Pro Gly Gly Pro Pro Ala Pro Thr Arg Pro Pro Cys Thr 145 150 155 160 Arg Asp Gly Pro Ser Asp Cys Val Leu Ala Ala Asp Trp Leu Pro Ser 165 170 175 Leu Met Leu Leu Leu Glu Gly Thr Arg Trp Gln Ala Leu Val Gln Leu 180 185 190 Gln Pro Ser Val Asp Pro Thr Asn Ala Thr Gly Leu Asp Gly Arg Glu 195 200 205 Pro Ala Pro His Phe Leu Gln Gly Leu Leu Gly Leu Leu Thr Pro Ala 210 215 220 Gly Glu Leu Gly Ser Glu Glu Ala Leu Trp Gly Gly Leu Leu Arg Thr 225 230 235 240 Val Gly Ala Pro Leu Tyr Ala Ala Phe Gln Glu Gly Leu Leu Arg Val 245 250 255 Thr His Ser Leu Gln Asp Glu Val Phe Ser Ile Met Gly Gln Pro Glu 260 265 270 Pro Asp Ala Ser Gly Gln Cys Gln Gly Gly Asn Leu Gln Gln Leu Leu 275 280 285 Leu Trp Gly Met Arg Asn Asn Leu Ser Trp Asp Ala Arg Ala Leu Gly 290 295 300 Phe Leu Ser Gly Ser Pro Pro Pro Pro Pro Ala Leu Leu His Cys Leu 305 310 315 320 Ser Arg Gly Val Pro Leu Pro Arg Ala Ser Gln Pro Ala Ala His Ile 325 330 335 Ser Pro Arg Gln Arg Arg Ala Ile Ser Val Glu Ala Leu Cys Glu Asn 340 345 350 His Ser Gly Pro Glu Pro Pro Tyr Ser Ile Ser Asn Phe Ser Ile Tyr 355 360 365 Leu Leu Cys Gln His Ile Lys Pro Ala Thr Pro Arg Pro Pro Pro Thr 370 375 380 Thr Pro Arg Pro Pro Pro Thr Thr Pro Gln Pro Pro Pro Thr Thr Thr 385 390 395 400 Gln Pro Ile Pro Asp Thr Thr Gln Pro Pro Pro Val Thr Pro Arg Pro 405 410 415 Pro Pro Thr Thr Pro Gln Pro Pro Pro Ser Thr Ala Val Ile Cys Gln 420 425 430 Thr Ala Val Trp Tyr Ala Val Ser Trp Ala Pro Gly Ala Arg Gly Trp 435 440 445 Leu Gln Ala Cys His Asp Gln Phe Pro Asp Gln Phe Leu Asp Met Ile 450 455 460 Cys Gly Asn Leu Ser Phe Ser Ala Leu Ser Gly Pro Ser Arg Pro Leu 465 470 475 480 Val Lys Gln Leu Cys Ala Gly Leu Leu Pro Pro Pro Thr Ser Cys Pro 485 490 495 Pro Gly Leu Ile Pro Val Pro Leu Thr Pro Glu Ile Phe Trp Gly Cys 500 505 510 Phe Leu Glu Asn Glu Thr Leu Trp Ala Glu Arg Leu Cys Val Glu Asp 515 520 525 Ser Leu Gln Ala Val Pro Pro Arg Asn Gln Ala Trp Val Gln His Val 530 535 540 Cys Arg Gly Pro Thr Leu Asp Ala Thr Asp Phe Pro Pro Cys Arg Val 545 550 555 560 Gly Pro Cys Gly Glu Arg Cys Pro Asp Gly Gly Ser Phe Leu Leu Met 565 570 575 Val Cys Ala Asn Asp Thr Leu Tyr Glu Ala Leu Val Pro Phe Trp Ala 580 585 590 Trp Leu Ala Gly Gln Cys Arg Ile Ser Arg Gly Gly Asn Asp Thr Cys 595 600 605 Phe Leu Glu Gly Met Leu Gly Pro Leu Leu Pro Ser Leu Pro Pro Leu 610 615 620 Gly Pro Ser Pro Leu Cys Leu Ala Pro Gly Pro Phe Leu Leu Gly Met 625 630 635 640 Leu Ser Gln Leu Pro Arg Cys Gln Ser Ser Val Pro Ala Leu Ala His 645 650 655 Pro Thr Arg Leu His Tyr Leu Leu Arg Leu Leu Thr Phe Leu Leu Gly 660 665 670 Pro Gly Thr Gly Gly Ala Glu Thr Gln Gly Met Leu Gly Gln Ala Leu 675 680 685 Leu Leu Ser Ser Leu Pro Asp Asn Cys Ser Phe Trp Asp Ala Phe Arg 690 695 700 Pro Glu Gly Arg Arg Ser Val Leu Arg Thr Val Gly Glu Tyr Leu Gln 705 710 715 720 Arg Glu Glu Pro Thr Pro Pro Gly Leu Asp Ser Ser Leu Ser Leu Gly 725 730 735 Ser Gly Met Ser Lys Met Glu Leu Leu Ser Cys Phe Ser Pro Val Leu 740 745 750 Trp Asp Leu Leu Gln Arg Glu Lys Ser Val Trp Ala Leu Arg Thr Leu 755 760 765 Val Lys Ala Tyr Leu Arg Met Pro Pro Glu Asp Leu Gln Gln Leu Val 770 775 780 Leu Ser Ala Glu Met Glu Ala Ala Gln Gly Phe Leu Thr Leu Met Leu 785 790 795 800 Arg Ser Trp Ala Lys Leu Lys Val Gln Pro Ser Glu Glu Gln Ala Met 805 810 815 Gly Arg Leu Thr Ala Leu Leu Leu Gln Arg Tyr Pro Arg Leu Thr Ser 820 825 830 Gln Leu Phe Ile Asp Met Ser Pro Leu Ile Pro Phe Leu Ala Val Pro 835 840 845 Asp Leu Met Arg Phe Pro Pro Ser Leu Leu Ala Asn Asp Ser Val Leu 850 855 860 Ala Ala Ile Arg Asp His Ser Ser Gly Met Lys Pro Glu Gln Lys Glu 865 870 875 880 Ala Leu Ala Lys Arg Leu Leu Ala Pro Glu Leu Phe Gly Glu Val Pro 885 890 895 Asp Trp Pro Gln Glu Leu Leu Trp Ala Ala Leu Pro Leu Leu Pro His 900 905 910 Leu Pro Leu Glu Ser Phe Leu Gln Leu Ser Pro His Gln Ile Gln Ala 915 920 925 Leu Glu Asp Ser Trp Pro Val Ala Asp Leu Gly Pro Gly His Ala Arg 930 935 940 His Val Leu Arg Ser Leu Val Asn Gln Ser Met Glu Asp Gly Glu Glu 945 950 955 960 Gln Val Leu Arg Leu Gly Ser Leu Ala Cys Phe Leu Ser Pro Glu Glu 965 970 975 Leu Gln Ser Leu Val Pro Leu Ser Asp Pro Met Gly Pro Val Glu Gln 980 985 990 Gly Leu Leu Glu Cys Ala Ala Asn Gly Thr Leu Ser Pro Glu Gly Arg 995 1000 1005 Val Ala Tyr Glu Leu Leu Gly Val Leu Arg Ser Ser Gly Gly Thr 1010 1015 1020 Val Leu Ser Pro Arg Glu Leu Arg Val Trp Ala Pro Leu Phe Pro 1025 1030 1035 Gln Leu Gly Leu Arg Phe Leu Gln Glu Leu Ser Glu Thr Gln Leu 1040 1045 1050 Arg Ala Met Leu Pro Ala Leu Gln Gly Ala Ser Val Thr Pro Ala 1055 1060 1065 Gln Ala Val Leu Leu Phe Gly Arg Leu Leu Pro Lys His Asp Leu 1070 1075 1080 Ser Leu Glu Glu Leu Cys Ser Leu His Pro Leu Leu Pro Gly Leu 1085 1090 1095 Ser Pro Gln Thr Leu Gln Ala Ile Pro Lys Arg Val Leu Val Gly 1100 1105 1110 Ala Cys Ser Cys Leu Gly Pro Glu Leu Ser Arg Leu Ser Ala Cys 1115 1120 1125 Gln Ile Ala Ala Leu Leu Gln Thr Phe Arg Val Lys Asp Gly Val 1130 1135 1140 Lys Asn Met Gly Ala Ala Gly Ala Gly Ser Ala Val Cys Ile Pro 1145 1150 1155 Gly Gln Pro Thr Thr Trp Pro Asp Cys Leu Leu Pro Leu Leu Pro 1160 1165 1170 Leu Lys Leu Leu Gln Leu Asp Ala Ala Ala Leu Leu Ala Asn Arg 1175 1180 1185 Arg Leu Tyr Arg Gln Leu Pro Trp Ser Glu Gln Gln Ala Gln Phe 1190 1195 1200 Leu Trp Lys Lys Met Gln Val Pro Thr Asn Leu Ser Leu Arg Asn 1205 1210 1215 Leu Gln Ala Leu Gly Asn Leu Ala Gly Gly Met Thr Cys Glu Phe 1220 1225 1230 Leu Gln Gln Ile Ser Ser Met Val Asp Phe Leu Asp Val Val His 1235 1240 1245 Met Leu Tyr Gln Leu Pro Thr Gly Val Arg Glu Ser Leu Arg Ala 1250 1255 1260 Cys Ile Trp Thr Glu Leu Gln Arg Arg Met Thr Met Pro Glu Pro 1265 1270 1275 Glu Leu Thr Thr Leu Gly Pro Glu Leu Ser Glu Leu Asp Thr Lys 1280 1285 1290 Leu Leu Leu Asp Leu Pro Ile Gln Leu Met Asp Arg Leu Ser Asn 1295 1300 1305 Asp Ser Ile Met Leu Val Val Glu Met Val Gln Gly Ala Pro Glu 1310 1315 1320 Gln Leu Leu Ala Leu Thr Pro Leu His Gln Thr Ala Leu Ala Glu 1325 1330 1335 Arg Ala Leu Lys Asn Leu Ala Pro Lys Glu Thr Pro Ile Ser Lys 1340 1345 1350 Glu Val Leu Glu Thr Leu Gly Pro Leu Val Gly Phe Leu Gly Ile 1355 1360 1365 Glu Ser Thr Arg Arg Ile Pro Leu Pro Ile Leu Leu Ser His Leu 1370 1375 1380 Ser Gln Leu Gln Gly Phe Cys Leu Gly Glu Thr Phe Ala Thr Glu 1385 1390 1395 Leu Gly Trp Leu Leu Leu Gln Glu Pro Val Leu Gly Lys Pro Glu 1400 1405 1410 Leu Trp Ser Gln Asp Glu Ile Glu Gln Ala Gly Arg Leu Val Phe 1415 1420 1425 Thr Leu Ser Ala Glu Ala Ile Ser Ser Ile Pro Arg Glu Ala Leu 1430 1435 1440 Gly Pro Glu Thr Leu Glu Arg Leu Leu Gly Lys His Gln Ser Trp 1445 1450 1455 Glu Gln Ser Arg Val Gly His Leu Cys Gly Glu Ser Gln Leu Ala 1460 1465 1470 His Lys Lys Ala Ala Leu Val Ala Gly Ile Val His Pro Ala Ala 1475 1480 1485 Glu Gly Leu Gln Glu Pro Val Pro Asn Cys Ala Asp Ile Arg Gly 1490 1495 1500 Thr Phe Pro Ala Ala Trp Ser Ala Thr Gln Ile Ser Glu Met Glu 1505 1510 1515 Leu Ser Asp Phe Glu Asp Cys Leu Ser Leu Phe Ala Gly Asp Pro 1520 1525 1530 Gly Leu Gly Pro Glu Glu Leu Arg Ala Ala Met Gly Lys Ala Lys 1535 1540 1545 Gln Leu Trp Gly Pro Pro Arg Gly Phe Arg Pro Glu Gln Ile Leu 1550 1555 1560 Gln Leu Gly Arg Leu Leu Ile Gly Leu Gly Glu Arg Glu Leu Gln 1565 1570 1575 Glu Leu Thr Leu Val Asp Trp Gly Val Leu Ser Ser Leu Gly Gln 1580 1585 1590 Ile Asp Gly Trp Ser Ser Met Gln Leu Arg Ala Val Val Ser Ser 1595 1600 1605 Phe Leu Arg Gln Ser Gly Arg His Val Ser His Leu Asp Phe Ile 1610 1615 1620 Tyr Leu Thr Ala Leu Gly Tyr Thr Val Cys Gly Leu Arg Pro Glu 1625 1630 1635 Glu Leu Gln His Ile Ser Ser Trp Glu Phe Ser Gln Ala Ala Leu 1640 1645 1650 Phe Leu Gly Ser Leu His Leu Pro Cys Ser Glu Glu Gln Leu Glu 1655 1660 1665 Val Leu Ala Tyr Leu Leu Val Leu Pro Gly Gly Phe Gly Pro Val 1670 1675 1680 Ser Asn Trp Gly Pro Glu Ile Phe Thr Glu Ile Gly Thr Ile Ala 1685 1690 1695 Ala Gly Ile Pro Asp Leu Ala Leu Ser Ala Leu Leu Arg Gly Gln 1700 1705 1710 Ile Gln Gly Leu Thr Pro Leu Ala Ile Ser Val Ile Pro Ala Pro 1715 1720 1725 Lys Phe Ala Val Val Phe Asn Pro Ile Gln Leu Ser Ser Leu Thr 1730 1735 1740 Arg Gly Gln Ala Val Ala Val Thr Pro Glu Gln Leu Ala Tyr Leu 1745 1750 1755 Ser Pro Glu Gln Arg Arg Ala Val Ala Trp Ala Gln His Glu Gly 1760 1765 1770 Lys Glu Ile Pro Glu Gln Leu Gly Arg Asn Ser Ala Trp Gly Leu 1775 1780 1785 Tyr Asp Trp Phe Gln Ala Ser Trp Ala Leu Ala Leu Pro Val Ser 1790 1795 1800 Ile Phe Gly His Leu Leu 1805 <210> 6 <211> 5328 <212> ADN <213> Homo sapiens <400> 6 atggctctca gcctctggcc cctgctgctg ctgctgctgc tgctgctgct gctgtccttt 60 gcagtgactc tggcccctac tgggcctcat tccctggacc ctggtctctc cttcctgaag 120 tcattgctct ccactctgga ccaggctccc cagggctccc tgagccgctc acggttcttt 180 acattcctgg ccaacatttc ttcttccttt gagcctggga gaatggggga aggaccagta 240 ggagagcccc cacctctcca gccgcctgct ctgcggctcc atgattttct agtgacactg 300 agaggtagcc ccgactggga gccaatgcta gggctgctag gggatatgct ggcactgctg 360 ggacaggagc agactccccg agatttcctg gtgcaccagg caggggtgct gggtggactt 420 gtggaggtgc tgctgggagc cttagttcct gggggccccc ctaccccaac tcggccccca 480 tgcacccgtg atgggccgtc tgactgtgtc ctggctgctg actggttgcc ttctctgctg 540 ctgttgttag agggcacacg ctggcaagct ctggtgcagg tgcagcccag tgtggacccc 600 accaatgcca caggcctcga tgggagggag gcagctcctc actttttgca gggtctgttg 660 ggtttgctta ccccaacagg ggagctaggc tccaaggagg ctctttgggg cggtctgcta 720 cgcacagtgg gggcccccct ctatgctgcc tttcaggagg ggctgctccg tgtcactcac 780 tccctgcagg atgaggtctt ctccattttg gggcagccag agcctgatac caatgggcag 840 tgccagggag gtaaccttca acagctgctc ttatggggcg tccggcacaa cctttcctgg 900 gatgtccagg cgctgggctt tctgtctgga tcaccacccc caccccctgc cctccttcac 960 tgcctgagca cgggcgtgcc tctgcccaga gcttctcagc cgtcagccca catcagccca 1020 cgccaacggc gagccatcac tgtggaggcc ctctgtgaga accacttagg cccagcacca 1080 ccctacagca tttccaactt ctccatccac ttgctctgcc agcacaccaa gcctgccact 1140 ccacagcccc atcccagcac cactgccatc tgccagacag ctgtgtggta tgcagtgtcc 1200 tgggcaccag gtgcccaagg ctggctacag gcctgccacg accagtttcc tgatgagttt 1260 ttggatgcga tctgcagtaa cctctccttt tcagccctgt ctggctccaa ccgccgcctg 1320 gtgaagcggc tctgtgctgg cctgctccca ccccctacca gctgccctga aggcctgccc 1380 cctgttcccc tcaccccaga catcttttgg ggctgcttct tggagaatga gactctgtgg 1440 gctgagcgac tgtgtgggga ggcaagtcta caggctgtgc cccccagcaa ccaggcttgg 1500 gtccagcatg tgtgccaggg ccccacccca gatgtcactg cctccccacc atgccacatt 1560 ggaccctgtg gggaacgctg cccggatggg ggcagcttcc tggtgatggt ctgtgccaat 1620 gacaccatgt atgaggtcct ggtgcccttc tggccttggc tagcaggcca atgcaggata 1680 agtcgtgggg gcaatgacac ttgcttccta gaagggctgc tgggccccct tctgccctct 1740 ctgccaccac tgggaccatc cccactctgt ctgacccctg gccccttcct ccttggcatg 1800 ctatcccagt tgccacgctg tcagtcctct gtcccagctc ttgctcaccc cacacgccta 1860 cactatctcc tccgcctgct gaccttcctc ttgggtccag gggctggggg cgctgaggcc 1920 caggggatgc tgggtcgggc cctactgctc tccagtctcc cagacaactg ctccttctgg 1980 gatgcctttc gcccagaggg ccggcgcagt gtgctacgga cgattgggga atacctggaa 2040 caagatgagg agcagccaac cccatcaggc tttgaaccca ctgtcaaccc cagctctggt 2100 ataagcaaga tggagctgct ggcctgcttt agtcctgtgc tgtgggatct gctccagagg 2160 gaaaagagtg tttgggccct gcagattcta gtgcaggcgt acctgcatat gcccccagaa 2220 aacctccagc agctggtgct ttcagcagag agggaggctg cacagggctt cctgacactc 2280 atgctgcagg ggaagctgca ggggaagctg caggtaccac catccgagga gcaggccctg 2340 ggtcgcctga cagccctgct gctccagcgg tacccacgcc tcacctccca gctcttcatt 2400 gacctgtcac cactcatccc tttcttggct gtctctgacc tgatgcgctt cccaccatcc 2460 ctgttagcca acgacagtgt cctggctgcc atccgggatt acagcccagg aatgaggcct 2520 gaacagaagg aggctctggc aaagcgactg ctggcccctg aactgtttgg ggaagtgcct 2580 gcctggcccc aggagctgct gtgggcagtg ctgcccctgc tcccccacct ccctctggag 2640 aactttttgc agctcagccc tcaccagatc caggccctgg aggatagctg gccagcagca 2700 ggtctggggc cagggcatgc ccgccatgtg ctgcgcagcc tggtaaacca gagtgtccag 2760 gatggtgagg agcaggtacg caggcttggg cccctcgcct gtttcctgag ccctgaggag 2820 ctgcagagcc tagtgcccct gagtgatcca acggggccag tagaacgggg gctgctggaa 2880 tgtgcagcca atgggaccct cagcccagaa ggacgggtgg catatgaact tctgggtgtg 2940 ttgcgctcat ctggaggagc ggtgctgagc ccccgggagc tgcgggtctg ggcccctctc 3000 ttctctcagc tgggcctccg cttccttcag gagctgtcag agccccagct tagagccatg 3060 cttcctgtcc tgcagggaac tagtgttaca cctgctcagg ctgtcctgct gcttggacgg 3120 ctccttccta ggcacgatct atccctggag gaactctgct ccttgcacct tctgctacca 3180 ggcctcagcc cccagacact ccaggccatc cctaggcgag tcctggtcgg ggcttgttcc 3240 tgcctggccc ctgaactgtc acgcctctca gcctgccaga ccgcagcact gctgcagacc 3300 tttcgggtta aagatggtgt taaaaatatg ggtacaacag gtgctggtcc agctgtgtgt 3360 atccctggtc agcctattcc caccacctgg ccagactgcc tgcttcccct gctcccatta 3420 aagctgctac aactggattc cttggctctt ctggcaaatc gaagacgcta ctgggagctg 3480 ccctggtctg agcagcaggc acagtttctc tggaagaaga tgcaagtacc caccaacctt 3540 accctcagga atctgcaggc tctgggcacc ctggcaggag gcatgtcctg tgagtttctg 3600 cagcagatca actccatggt agacttcctt gaagtggtgc acatgatcta tcagctgccc 3660 actagagttc gagggagcct gagggcctgt atctgggcag agctacagcg gaggatggca 3720 atgccagaac cagaatggac aactgtaggg ccagaactga acgggctgga tagcaagcta 3780 ctcctggact taccgatcca gttgatggac agactatcca atgaatccat tatgttggtg 3840 gtggagctgg tgcaaagagc tccagagcag ctgctggcac tgacccccct ccaccaggca 3900 gccctggcag agagggcact acaaaacctg gctccaaagg agactccagt ctcaggggaa 3960 gtgctggaga ccttaggccc tttggttgga ttcctgggga cagagagcac acgacagatc 4020 cccctacaga tcctgctgtc ccatctcagt cagctgcaag gcttctgcct aggagagaca 4080 tttgccacag agctgggatg gctgctattg caggagtctg ttcttgggaa accagagttg 4140 tggagccagg atgaagtaga gcaagctgga cgcctagtat tcactctgtc tactgaggca 4200 atttccttga tccccaggga ggccttgggt ccagagaccc tggagcggct tctagaaaag 4260 cagcagagct gggagcagag cagagttgga cagctgtgta gggagccaca gcttgctgcc 4320 aagaaagcag ccctggtagc aggggtggtg cgaccagctg ctgaggatct tccagaacct 4380 gtgccaaatt gtgcagatgt acgagggaca ttcccagcag cctggtctgc aacccagatt 4440 gcagagatgg agctctcaga ctttgaggac tgcctgacat tatttgcagg agacccagga 4500 cttgggcctg aggaactgcg ggcagccatg ggcaaagcaa aacagttgtg gggtcccccc 4560 cggggatttc gtcctgagca gatcctgcag cttggtaggc tcttaatagg tctaggagat 4620 cgggaactac aggagctgat cctagtggac tggggagtgc tgagcaccct ggggcagata 4680 gatggctgga gcaccactca gctccgcatt gtggtctcca gtttcctacg gcagagtggt 4740 cggcatgtga gccacctgga cttcgttcat ctgacagcgc tgggttatac tctctgtgga 4800 ctgcggccag aggagctcca gcacatcagc agttgggagt tcagccaagc agctctcttc 4860 ctcggcaccc tgcatctcca gtgctctgag gaacaactgg aggttctggc ccacctactt 4920 gtactgcctg gtgggtttgg cccaatcagt aactgggggc ctgagatctt cactgaaatt 4980 ggcaccatag cagctgggat cccagacctg gctctttcag cactgctgcg gggacagatc 5040 cagggcgtta ctcctcttgc catttctgtc atccctcctc ctaaatttgc tgtggtgttt 5100 agtcccatcc aactatctag tctcaccagt gctcaggctg tggctgtcac tcctgagcaa 5160 atggcctttc tgagtcctga gcagcgacga gcagttgcat gggcccaaca tgagggaaag 5220 gagagcccag aacagcaagg tcgaagtaca gcctggggcc tccaggactg gtcacgacct 5280 tcctggtccc tggtattgac tatcagcttc cttggccacc tgctatga 5328 <210> 7 <211> 5430 <212> ADN <213> Mus musculus <400> 7 atggctctga gcctccagcc ccagctgctc cttctcctgt cgctcctgcc gcaggaagtg 60 acttcagccc ctactgggcc tcagtctttg gatgctggtc tctcccttct gaagtcattc 120 gtagccactc tggaccaagc tcctcagcgt tccctcagcc agtcacggtt ctctgcgttc 180 ctggccaaca tttcttcatc cttccagctt gggaggatgg gggagggacc ggtgggagag 240 cccccacctc tccagccccc tgcacttcga cttcatgatt tcctcgtgac actgagaggt 300 agcccagact gggagccaat gctagggctt ctgggagatg tgctggcact cctgggacag 360 gaacagactc cccgggactt tttggtgcac caggcaggtg tactgggtgg acttgtagag 420 gcattgttgg gagcgttagt tcctggaggc ccccctgccc ccactcgacc cccatgcacc 480 cgtgatggcc cttctgactg tgtcctggct gctgattggt tgccttctct gatgttgtta 540 ttagagggta cacgctggca ggccctggtg cagttgcagc ccagtgtgga cccaaccaat 600 gccacaggtc ttgatggtag agagccagct cctcactttt tacagggtct gctgggcttg 660 cttaccccag caggagagtt gggctctgag gaggctcttt ggggtggtct gctgcgcaca 720 gtgggggccc ccctctatgc tgccttccag gaggggctac tgcgagtcac tcattctctg 780 caagatgagg tcttttctat tatgggacag ccagagcctg atgccagtgg gcagtgccag 840 ggaggcaacc ttcaacagct gcttttatgg ggcatgcgga acaacctttc ttgggacgcc 900 cgagcactgg gttttctatc tggatcacca cctccacccc ctgctctcct gcactgcctg 960 agcagaggtg tgcctctgcc cagggcttcc cagcctgcgg ctcacatcag ccctcgacag 1020 cggcgagcca tctctgtgga ggccctctgc gagaaccact caggcccaga gccaccctac 1080 agcatctcca acttctccat ctacttgctc tgccagcaca tcaagcctgc caccccgcgg 1140 ccccctccta ccaccccacg gcctcctcct accaccccac agccccctcc taccactaca 1200 cagcccattc ctgacactac acagccccct cctgtcaccc caaggcctcc tcctaccacc 1260 ccacaacccc ctcctagcac agctgtcatc tgccagacag ctgtatggta cgcagtctcg 1320 tgggcaccag gtgcccgagg ttggctccaa gcctgccatg atcagtttcc tgatcaattt 1380 ctggatatga tctgcggcaa cctctcattt tcagccctgt ctggccccag tcgtcctttg 1440 gtaaagcagc tctgtgctgg cttgctccca ccccccacta gctgtccacc aggcctgatc 1500 cctgtgcccc tcaccccaga aatattctgg ggctgtttcc tggagaatga gacactgtgg 1560 gctgaacggt tgtgtgtgga ggacagtctg caggctgtgc ccccgaggaa ccaggcttgg 1620 gttcagcatg tgtgtcgggg ccccaccttg gacgccactg attttccacc gtgccgcgtt 1680 ggaccctgtg gggaacgctg cccagatggg ggcagcttcc tgctcatggt ctgtgccaat 1740 gacactctgt atgaagcctt ggttcccttc tgggcttggc tagcaggcca atgcagaatt 1800 agtcgtggag gaaatgatac ttgctttcta gaaggcatgc tgggcccctt gttgccctct 1860 ctgccccctc tgggaccatc cccactctgt ctggctcctg gtccttttct gcttggcatg 1920 ttatcccagt tgccacgctg tcagtcctcc gtgccagccc tcgcccaccc cacgcgccta 1980 cattacctcc tgcgcctact gaccttcctt ctgggtccag ggactggggg tgccgagacg 2040 caggggatgt taggtcaagc cctgctgctc tctagtctcc cagacaactg ttcattctgg 2100 gatgccttcc gcccagaggg ccggagaagt gtactgagga cagtcggaga gtacttgcag 2160 cgggaagagc caaccccacc aggcttagac tcctccctca gcctcggctc tggtatgagc 2220 aagatggagc ttctgtcctg cttcagtcct gtactgtggg atctactcca gagagagaag 2280 agcgtttggg ccctgaggac cctggtgaag gcctacctgc gcatgcctcc agaagacctt 2340 cagcagcttg tgctttcagc agagatggag gctgcacagg gcttcctgac gctcatgctt 2400 cgttcctggg ctaagctgaa ggttcaacca tccgaggagc aggccatggg ccgcctgaca 2460 gccttgctgc tccagcggta cccacgcctc acctcccaac tctttatcga catgtcaccg 2520 ctcatcccct tcctggctgt ccctgacctc atgcgcttcc caccgtccct tttggccaac 2580 gacagtgtcc tggctgccat cagggatcac agctcaggaa tgaagcctga acagaaggag 2640 gccctggcaa aacgactgct ggcccctgag ctgtttggag aagtgcctga ttggccccag 2700 gagctgctgt gggcagccct gcctctgctt ccccatctgc ctctggagag ctttctccag 2760 ctcagccctc accagatcca ggccctggag gatagctggc cagtagcaga tcttgggccg 2820 ggacacgccc gacatgtgct tcgtagccta gtaaaccaga gcatggagga tggggaggag 2880 caggtgctca ggcttgggtc cctcgcctgt ttcctgagtc ctgaggagct acagagtctg 2940 gtgcccttga gtgatccaat ggggcctgta gaacagggtc tgctggaatg tgcggccaat 3000 gggaccctca gcccagaagg acgggtggca tatgaacttc tgggagtgtt gcgttcatct 3060 ggaggaactg tcttaagccc ccgagagctg agggtctggg cacctctctt tccccagctg 3120 ggcctccgct tcctgcagga gctctcagag acccagctta gagccatgct tcctgcccta 3180 cagggagcca gtgtcacacc tgcccaggct gttctgttgt ttggaaggct ccttcctaag 3240 catgatctgt ccctggagga actctgctcc ctgcaccctc tcctgccagg tctcagcccc 3300 cagacactcc aggccatccc taagagagtt ctggttggtg cttgttcctg cctgggccct 3360 gaactgtcaa ggctttcagc ttgccagatt gcagctctgc tgcagacctt tcgggtaaaa 3420 gatggtgtta aaaatatggg tgcagcaggt gccggctcag ccgtgtgcat tcctgggcag 3480 cccaccactt ggccagactg cctgcttccc ctgctcccat taaagctgct acagctggac 3540 gctgcagctc ttctggcaaa ccgaagactc tatcggcagc tgccttggtc tgagcaacag 3600 gcacagtttc tctggaagaa aatgcaagtg cctaccaacc tgagcctgag gaatctgcag 3660 gctctgggca acttggcagg aggcatgacc tgcgagtttc tgcagcagat cagctcaatg 3720 gttgactttc ttgatgtggt acacatgctc taccagctgc ccactggtgt tcgagagagc 3780 ctgcgggcct gtatctggac agagctacag cggaggatga caatgccaga gccagagctg 3840 accaccctag ggccagaact gagtgaactt gacacaaagc tactcctgga cttgccgatc 3900 cagctgatgg acagattgtc caatgattcc attatgttgg tggtggagat ggtccaaggc 3960 gctccagagc agctgctggc actgacccca ctccaccaga cagccttggc agagcgagca 4020 cttaaaaacc tggctccaaa ggagacccca atctccaaag aagtgctgga gacactgggc 4080 cccttggttg gattcctggg aatagagagc acgcgacgga tccctttacc cattctactg 4140 tctcatctca gtcagctgca gggcttctgc ctaggagaga catttgccac agagctggga 4200 tggctgctgt tgcaggagcc tgttcttgga aaaccagaat tgtggagcca ggatgaaata 4260 gagcaagctg gacgcctagt attcactctg tctgctgagg ctatttcctc gatccccagg 4320 gaggctttgg gcccagagac actggagagg cttctgggaa agcatcaaag ctgggagcag 4380 agcagagtgg gccatctgtg tggggagtca cagcttgccc acaagaaagc agctctggta 4440 gctgggattg tgcatccagc tgctgagggt ctccaagagc ctgtaccaaa ctgtgcagac 4500 atacggggaa ccttcccagc ggcctggtct gcgacacaaa tctcagagat ggaactctca 4560 gactttgaag actgcctgtc actatttgct ggagatccag gacttggtcc tgaggaacta 4620 cgggcagcca tgggcaaggc caagcagttg tggggtcccc ctcgaggatt ccgtcctgag 4680 cagatcttgc agctgggccg tctcctgata ggtctaggag aacgggaact gcaggagctt 4740 accttggtgg actggggtgt gctgagcagc ctggggcaaa tagatggctg gagttccatg 4800 cagctccgag ccgtggtctc cagtttccta aggcagagtg gtcggcatgt gagccacctg 4860 gacttcattt atctgacagc actgggttac acagtctgtg gattgcgacc agaggagtta 4920 cagcacatca gcagttggga gtttagccaa gcagctctct tcctgggtag cttgcatctc 4980 ccgtgctctg aggaacagct ggaagttctg gcctatctcc ttgtgttgcc tggtggcttt 5040 ggcccagtca gtaactgggg gcctgagatc ttcactgaaa ttggcacaat agcagctggc 5100 atcccagacc tggctctttc agcattactg cggggacaga tccaaggcct gactcctctt 5160 gccatttctg tcattcctgc tcccaagttt gcagtggtct tcaaccccat ccagttatct 5220 agtctcacca ggggtcaggc cgtagctgtt actcctgaac agctggccta tctgagtcct 5280 gagcagcggc gagcagttgc atgggcccaa cacgaaggga aggagatccc agagcagctg 5340 ggtcgaaact cagcctgggg tctctacgac tggttccaag cctcctgggc cctggcattg 5400 cccgtcagca tttttggcca cctattatga 5430 <210> 8 <211> 92 <212> PRT <213> Secuencia artificial <220> <223> Construcción sintética <400> 8 Cys Leu Ser Tyr Asp Thr Glu Ile Leu Thr Val Glu Tyr Gly Phe Leu 1 5 10 15 Pro Ile Gly Lys Ile Val Glu Glu Arg Ile Glu Cys Thr Val Tyr Thr 20 25 30 Val Asp Lys Asn Gly Phe Val Tyr Thr Gln Pro Ile Ala Gln Trp His 35 40 45 Asn Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser 50 55 60 Ile Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Thr Asp Gly Gln 65 70 75 80 Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Gly Leu 85 90 <210> 9 <211> 35 <212> PRT <213> Secuencia artificial <220> <223> Construcción sintética <400> 9 Val Lys Ile Ile Ser Arg Lys Ser Leu Gly Thr Gln Asn Val Tyr Asp 1 5 10 15 Ile Gly Val Glu Lys Asp His Asn Phe Leu Leu Lys Asn Gly Leu Val 20 25 30 Ala Ser Asn 35 <210> 10 <211> 101 <212> PRT <213> Secuencia artificial <220> <223> Construcción sintética <400> 10 Cys Leu Ser Tyr Asp Thr Glu Ile Leu Thr Val Glu Tyr Gly Phe Leu 1 5 10 15 Pro Ile Gly Lys Ile Val Glu Glu Arg Ile Glu Cys Thr Val Tyr Thr 20 25 30 Val Asp Lys Asn Gly Phe Val Tyr Thr Gln Pro Ile Ala Gln Trp His 35 40 45 Asn Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser 50 55 60 Ile Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Thr Asp Gly Gln 65 70 75 80 Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Gly Leu Asp Leu Lys Gln 85 90 95 Val Asp Gly Leu Pro 100 <210> 11 <211> 36 <212> PRT <213> Secuencia artificial <220> <223> Construcción sintética <400> 11 Met Val Lys Ile Ile Ser Arg Lys Ser Leu Gly Thr Gln Asn Val Tyr 1 5 10 15 Asp Ile Gly Val Glu Lys Asp His Asn Phe Leu Leu Lys Asn Gly Leu 20 25 30 Val Ala Ser Asn 35 <210> 12 <211> 35 <212> PRT <213> Secuencia artificial <220> <223> Construcción sintética <400> 12 Val Lys Ile Ile Ser Arg Lys Ser Leu Gly Thr Gln Asn Val Tyr Asp 1 5 10 15 Ile Gly Val Gly Glu Pro His Asn Phe Leu Leu Lys Asn Gly Leu Val 20 25 30 Ala Ser Asn 35 <210> 13 <211> 102 <212> PRT <213> Secuencia artificial <220> <223> Construcción sintética <400> 13 Cys Leu Ser Tyr Glu Thr Glu Ile Leu Thr Val Glu Tyr Gly Leu Leu 1 5 10 15 Pro Ile Gly Lys Ile Val Glu Lys Arg Ile Glu Cys Thr Val Tyr Ser 20 25 30 Val Asp Asn Asn Gly Asn Ile Tyr Thr Gln Pro Val Ala Gln Trp His 35 40 45 Asp Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser 50 55 60 Leu Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Val Asp Gly Gln 65 70 75 80 Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Glu Leu Asp Leu Met Arg 85 90 95 Val Asp Asn Leu Pro Asn 100 <210> 14 <211> 36 <212> PRT <213> Secuencia artificial <220> <223> Construcción sintética <400> 14 Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn Val Tyr 1 5 10 15 Asp Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu Lys Asn Gly Phe 20 25 30 Ile Ala Ser Asn 35 <210> 15 <211> 101 <212> PRT <213> Secuencia artificial <220> <223> Construcción sintética <400> 15 Cys Leu Ser Tyr Asp Thr Glu Ile Leu Thr Val Glu Tyr Gly Phe Leu 1 5 10 15 Pro Ile Gly Lys Ile Val Glu Glu Arg Ile Glu Cys Thr Val Tyr Thr 20 25 30 Val Asp Lys Asn Gly Phe Val Tyr Thr Gln Pro Ile Ala Gln Trp His 35 40 45 Asn Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser 50 55 60 Ile Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Thr Asp Gly Gln 65 70 75 80 Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Gly Leu Asp Leu Lys Gln 85 90 95 Val Asp Gly Leu Pro 100 <210> 16 <211> 53 <212> PRT <213> Secuencia artificial <220> <223> Construcción sintética <400> 16 Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 1 5 10 15 Arg Lys Val Lys Ile Ile Ser Arg Lys Ser Leu Gly Thr Gln Asn Val 20 25 30 Tyr Asp Ile Gly Val Glu Lys Asp His Asn Phe Leu Leu Lys Asn Gly 35 40 45 Leu Val Ala Ser Asn 50 <210> 17 <211> 12 <212> PRT <213> Secuencia artificial <220> <223> Construcción sintética <400> 17 Cys Phe Ser Gly Asp Thr Leu Val Ala Leu Thr Asp 1 5 10 <210> 18 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> Construcción sintética <400> 18 Cys Leu Ala Gly Asp Thr Leu Ile Thr Leu Ala 1 5 10 <210> 19 <211> 10 <212> PRT <213> Secuencia artificial <220> <223> Construcción sintética <400> 19 Cys Leu Gln Asn Gly Thr Arg Leu Leu Arg 1 5 10 <210> 20 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> Construcción sintética <400> 20 Cys Leu Thr Gly Asp Ser Gln Val Leu Thr Arg 1 5 10 <210> 21 <211> 11 <212> PRT <213> Secuencia artificial <220> <223> Construcción sintética <400> 21 Cys Leu Thr Tyr Glu Thr Glu Ile Met Thr Val 1 5 10 <210> 22 <211> 12 <212> PRT <213> Secuencia artificial <220> <223> Construcción sintética <400> 22 Cys Leu Ser Gly Asn Thr Lys Val Arg Phe Arg Tyr 1 5 10 <210> 23 <211> 6 <212> PRT <213> Secuencia artificial <220> <223> Construcción sintética <400> 23 Gly Val Phe Val His Asn 1 5 <210> 24 <211> 6 <212> PRT <213> Secuencia artificial <220> <223> Construcción sintética <400> 24 Gly Leu Leu Val His Asn 1 5 <210> 25 <211> 6 <212> PRT <213> Secuencia artificial <220> <223> Construcción sintética <400> 25 Gly Leu Ile Ala Ser Asn 1 5 <210> 26 <211> 6 <212> PRT <213> Secuencia artificial <220> <223> Construcción sintética <400> 26 Gly Leu Val Val His Asn 1 5 <210> 27 <211> 102 <212> PRT <213> Secuencia artificial <220> <223> Construcción sintética <400> 27 Cys Leu Ser Tyr Glu Thr Glu Ile Leu Thr Val Glu Tyr Gly Leu Leu 1 5 10 15 Pro Ile Gly Lys Ile Val Glu Lys Arg Ile Glu Cys Thr Val Tyr Ser 20 25 30 Val Asp Asn Asn Gly Asn Ile Tyr Thr Gln Pro Val Ala Gln Trp His 35 40 45 Asp Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser 50 55 60 Leu Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Val Asp Gly Gln 65 70 75 80 Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Glu Leu Asp Leu Met Arg 85 90 95 Val Asp Asn Leu Pro Asn 100 <210> 28 <211> 35 <212> PRT <213> Secuencia artificial <220> <223> Construcción sintética <400> 28 Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn Val Tyr Asp 1 5 10 15 Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu Lys Asn Gly Phe Ile 20 25 30 Ala Ser Asn 35 <210> 29 <211> 106 <212> PRT <213> Secuencia artificial <220> <223> Construcción sintética <400> 29 Cys Leu Ala Gly Asp Thr Leu Ile Thr Leu Ala Asp Gly Arg Arg Val 1 5 10 15 Pro Ile Arg Glu Leu Val Ser Gln Gln Asn Phe Ser Val Trp Ala Leu 20 25 30 Asn Pro Gln Thr Tyr Arg Leu Glu Arg Ala Arg Val Ser Arg Ala Phe 35 40 45 Cys Thr Gly Ile Lys Pro Val Tyr Arg Leu Thr Thr Arg Leu Gly Arg 50 55 60 Ser Ile Arg Ala Thr Ala Asn His Arg Phe Leu Thr Pro Gln Gly Trp 65 70 75 80 Lys Arg Val Asp Glu Leu Gln Pro Gly Asp Tyr Leu Ala Leu Pro Arg 85 90 95 Arg Ile Pro Thr Ala Ser Thr Pro Thr Leu 100 105 <210> 30 <211> 51 <212> PRT <213> Secuencia artificial <220> <223> Construcción sintética <400> 30 Ala Ala Ala Cys Pro Glu Leu Arg Gln Leu Ala Gln Ser Asp Val Tyr 1 5 10 15 Trp Asp Pro Ile Val Ser Ile Glu Pro Asp Gly Val Glu Glu Val Phe 20 25 30 Asp Leu Thr Val Pro Gly Pro His Asn Phe Val Ala Asn Asp Ile Ile 35 40 45 Ala His Asn 50 <210> 31 <211> 102 <212> PRT <213> Secuencia artificial <220> <223> Construcción sintética <400> 31 Cys Leu Ser Tyr Asp Thr Glu Ile Leu Thr Val Glu Tyr Gly Ile Leu 1 5 10 15 Pro Ile Gly Lys Ile Val Glu Lys Arg Ile Glu Cys Thr Val Tyr Ser 20 25 30 Val Asp Asn Asn Gly Asn Ile Tyr Thr Gln Pro Val Ala Gln Trp His 35 40 45 Asp Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser 50 55 60 Leu Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Val Asp Gly Gln 65 70 75 80 Met Met Pro Ile Asp Glu Ile Phe Glu Arg Glu Leu Asp Leu Met Arg 85 90 95 Val Asp Asn Leu Pro Asn 100 <210> 32 <211> 35 <212> PRT <213> Secuencia artificial <220> <223> Construcción sintética <400> 32 Val Lys Val Ile Gly Arg Arg Ser Leu Gly Val Gln Arg Ile Phe Asp 1 5 10 15 Ile Gly Leu Pro Gln Tyr His Asn Phe Leu Leu Ala Asn Gly Ala Ile 20 25 30 Ala Ala Asn 35 <210> 33 <211> 101 <212> PRT <213> Secuencia artificial <220> <223> Construcción sintética <400> 33 Cys Leu Ser Tyr Asp Thr Glu Ile Leu Thr Val Glu Tyr Gly Phe Leu 1 5 10 15 Pro Ile Gly Lys Ile Val Glu Glu Arg Ile Glu Cys Thr Val Tyr Thr 20 25 30 Val Asp Lys Asn Gly Phe Val Tyr Thr Gln Pro Ile Ala Gln Trp His 35 40 45 Asn Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser 50 55 60 Ile Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Thr Asp Gly Gln 65 70 75 80 Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Gly Leu Asp Leu Lys Gln 85 90 95 Val Asp Gly Leu Pro 100 <210> 34 <211> 35 <212> PRT <213> Secuencia artificial <220> <223> Construcción sintética <400> 34 Val Lys Ile Ile Ser Arg Lys Ser Leu Gly Thr Gln Asn Val Tyr Asp 1 5 10 15 Ile Gly Val Glu Lys Asp His Asn Phe Leu Leu Lys Asn Gly Leu Val 20 25 30 Ala Ser Asn 35 <210> 35 <211> 101 <212> PRT <213> Secuencia artificial <220> <223> Construcción sintética <400> 35 Cys Leu Ser Tyr Asp Thr Glu Ile Leu Thr Val Glu Tyr Gly Phe Leu 1 5 10 15 Pro Ile Gly Lys Ile Val Glu Glu Arg Ile Glu Cys Thr Val Tyr Thr 20 25 30 Val Asp Lys Asn Gly Phe Val Tyr Thr Gln Pro Ile Ala Gln Trp His 35 40 45 Asn Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser 50 55 60 Ile Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Thr Asp Gly Gln 65 70 75 80 Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Gly Leu Asp Leu Lys Gln 85 90 95 Val Asp Gly Leu Pro 100 <210> 36 <211> 52 <212> PRT <213> Secuencia artificial <220> <223> Construcción sintética <400> 36 Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys Arg 1 5 10 15 Lys Val Lys Ile Ile Ser Arg Lys Ser Leu Gly Thr Gln Asn Val Tyr 20 25 30 Asp Ile Gly Val Glu Lys Asp His Asn Phe Leu Leu Lys Asn Gly Leu 35 40 45 Val Ala Ser Asn 50 <210> 37 <211> 123 <212> PRT <213> Secuencia artificial <220> <223> Construcción sintética <400> 37 Cys Leu Ser Phe Gly Thr Glu Ile Leu Thr Val Glu Tyr Gly Pro Leu 1 5 10 15 Pro Ile Gly Lys Ile Val Ser Glu Glu Ile Asn Cys Ser Val Tyr Ser 20 25 30 Val Asp Pro Glu Gly Arg Val Tyr Thr Gln Ala Ile Ala Gln Trp His 35 40 45 Asp Arg Gly Glu Gln Glu Val Leu Glu Tyr Glu Leu Glu Asp Gly Ser 50 55 60 Val Ile Arg Ala Thr Ser Asp His Arg Phe Leu Thr Thr Asp Tyr Gln 65 70 75 80 Leu Leu Ala Ile Glu Glu Ile Phe Ala Arg Gln Leu Asp Leu Leu Thr 85 90 95 Leu Glu Asn Ile Lys Gln Thr Glu Glu Ala Leu Asp Asn His Arg Leu 100 105 110 Pro Phe Pro Leu Leu Asp Ala Gly Thr Ile Lys 115 120 <210> 38 <211> 36 <212> PRT <213> Secuencia artificial <220> <223> Construcción sintética <400> 38 Val Lys Val Ile Gly Arg Arg Ser Leu Gly Val Gln Arg Ile Phe Asp 1 5 10 15 Ile Gly Leu Pro Gln Asp His Asn Phe Leu Leu Ala Asn Gly Ala Ile 20 25 30 Ala Ala Asn Cys 35 <210> 39 <211> 97 <212> PRT <213> Secuencia artificial <220> <223> Construcción sintética <400> 39 Cys Leu Ser Tyr Asp Thr Glu Ile Leu Thr Val Glu Tyr Gly Phe Leu 1 5 10 15 Pro Ile Gly Lys Ile Val Glu Glu Arg Ile Glu Cys Thr Val Tyr Thr 20 25 30 Val Asp Lys Asn Gly Phe Val Tyr Thr Gln Pro Ile Ala Gln Trp His 35 40 45 Asn Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser 50 55 60 Ile Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Thr Asp Gly Gln 65 70 75 80 Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Gly Leu Asp Leu Gln Val 85 90 95 Asp <210> 40 <211> 38 <212> PRT <213> Secuencia artificial <220> <223> Construcción sintética <400> 40 Gly Leu Pro Val Lys Ile Ile Ser Arg Lys Ser Leu Gly Thr Gln Asn 1 5 10 15 Val Tyr Asp Ile Gly Val Glu Lys Asp His Asn Phe Leu Leu Lys Asn 20 25 30 Gly Leu Val Ala Ser Asn 35 <210> 41 <211> 306 <212> ADN <213> Secuencia artificial <220> <223> Construcción sintética <400> 41 tgcctgagct acgagaccga gatcctgacc gtggagtacg gcctgctgcc catcggcaag 60 atcgtggaga agagaatcga gtgcaccgtg tacagcgtgg acaacaacgg caacatctac 120 acccagcccg tggcccagtg gcacgacaga ggcgagcagg aggtgttcga gtactgcctg 180 gaggacggca gcctgatcag agccaccaag gaccacaagt tcatgaccgt ggacggccag 240 atgctgccca tcgacgagat cttcgagaga gagctggacc tgatgagagt ggacaacctg 300 cccaac 306 <210> 42 <211> 105 <212> ADN <213> Secuencia artificial <220> <223> Construcción sintética <400> 42 atcaagatcg ccacaagaaa gtacctgggc aagcagaacg tgtacgacat cggcgtggag 60 agagaccaca acttcgccct gaagaacggc ttcatcgcca gcaat 105 <210> 43 <211> 7561 <212> ADN <213> Secuencia artificial <220> <223> Construcción sintética <400> 43 ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt 60 ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact 120 aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct 180 aggaagatcg gaattcgccc ttaagctagc ggcgcgccac cggtagcagg tttgttacag 240 aaaccttagt taaggtttgt tgagggtttt ttttctctct ctctctctta attggctgtc 300 ccaatccatc cttctataaa tagaaaagag agacagggag tgtgtgtggt ttcattacta 360 aggtaaagac acttgagcta cacacacttg atccctgaac atgaaatcta agaggttgaa 420 cgatcacagt ttcaggacta tataaggtgg tgaaagacca tctgcttcgt ttttctgttt 480 gttcctacaa ctctttccct ccgcttgatt ttaactctaa attggtgagt agctggtggg 540 ctcaccagac tccgagatcc tcttctctgc acgcactgta ttagacttgg cacccgggag 600 gattttcacc tctgctgcat gggctaatct tccacaaggg atctgtggta ttgcaatctc 660 gggttgatgc atgacggtga tgttgtgttt atagcatggc taaggtttag ctgcctatga 720 tgattggtta gggaaggata atttttgcta gaagattgga ctttagggaa aaaaaacccc 780 acttttattt gcttttagaa ttttaaaaga ctgggccatg tagctcaggc tggtttggag 840 ttcattatgt agtcaaggat gctcttggac tctttagcat cctcctcctc ctctttttcc 900 tcctcctcct tcttgttctt cttcttgttc ttcctcttcc ccttctcttc ccccttctct 960 ccctcttcct cctcttcctc ctccttcttg ttcttcttcc tcttcccctt ctcctctccc 1020 ccttgtcctc ctcttccttc tcctcctcct cctcttcttc tttctgagta ccaagattgc 1080 aagtgtgcac acgatgacca gcttggtctt tctttgtctt ttttttttaa cttcaatttt 1140 ggagtgaatt caagagcaac catgtagtca agaggtggct ggagtctttt ctgtatctgg 1200 gtttggttta gtactctgcc ccatcactta acaggtcctt atggccacat cttaaaaaaa 1260 ttctagagat acacggtgtc ggtgagtggc tgagaatgtg tggtcttccc atttctctgt 1320 caccgtggct cacatcttgt ttcctctgtt cggccaggta gaaaggcggc cgccatggct 1380 ctgagcctcc agccccagct gctccttctc ctgtcgctcc tgccgcagga agtgacttca 1440 gcccctactg ggcctcagtc tttggatgct ggtctctccc ttctgaagtc attcgtagcc 1500 actctggacc aagctcctca gcgttccctc agccagtcac ggttctctgc gttcctggcc 1560 aacatttctt catccttcca gcttgggagg atgggggagg gaccggtggg agagccccca 1620 cctctccagc cccctgcact tcgacttcat gatttcctcg tgacactgag aggtagccca 1680 gactgggagc caatgctagg gcttctggga gatgtgctgg cactcctggg acaggaacag 1740 actccccggg actttttggt gcaccaggca ggtgtactgg gtggacttgt agaggcattg 1800 ttgggagcgt tagttcctgg aggcccccct gcccccactc gacccccatg cacccgtgat 1860 ggcccttctg actgtgtcct ggctgctgat tggttgcctt ctctgatgtt gttattagag 1920 ggtacacgct ggcaggccct ggtgcagttg cagcccagtg tggacccaac caatgccaca 1980 ggtcttgatg gtagagagcc agctcctcac tttttacagg gtctgctggg cttgcttacc 2040 ccagcaggag agttgggctc tgaggaggct ctttggggtg gtctgctgcg cacagtgggg 2100 gcccccctct atgctgcctt ccaggagggg ctactgcgag tcactcattc tctgcaagat 2160 gaggtctttt ctattatggg acagccagag cctgatgcca gtgggcagtg ccagggaggc 2220 aaccttcaac agctgctttt atggggcatg cggaacaacc tttcttggga cgcccgagca 2280 ctgggttttc tatctggatc accacctcca ccccctgctc tcctgcactg cctgagcaga 2340 ggtgtgcctc tgcccagggc ttcccagcct gcggctcaca tcagccctcg acagcggcga 2400 gccatctctg tggaggccct ctgcgagaac cactcaggcc cagagccacc ctacagcatc 2460 tccaacttct ccatctactt gctctgccag cacatcaagc ctgccacccc gcggccccct 2520 cctaccaccc cacggcctcc tcctaccacc ccacagcccc ctcctaccac tacacagccc 2580 attcctgaca ctacacagcc ccctcctgtc accccaaggc ctcctcctac caccccacaa 2640 ccccctccta gcacagctgt catctgccag acagctgtat ggtacgcagt ctcgtgggca 2700 ccaggtgccc gaggttggct ccaagcctgc catgatcagt ttcctgatca atttctggat 2760 atgatctgcg gcaacctctc attttcagcc ctgtctggcc ccagtcgtcc tttggtaaag 2820 cagctctgtg ctggcttgct cccacccccc actagctgtc caccaggcct gatccctgtg 2880 cccctcaccc cagaaatatt ctggggctgt ttcctggaga atgagacact gtgggctgaa 2940 cggttgtgtg tggaggacag tctgcaggct gtgcccccga ggaaccaggc ttgggttcag 3000 catgtgtgtc ggggccccac cttggacgcc actgattttc caccgtgccg cgttggaccc 3060 tgtggggaac gctgcccaga tgggggcagc ttcctgctca tggtctgtgc caatgacact 3120 ctgtatgaag ccttggttcc cttctgggct tggctagcag gccaatgcag aattagtcgt 3180 ggaggaaatg atacttgctt tctagaaggc atgctgggcc ccttgttgcc ctctctgccc 3240 cctctgggac catccccact ctgtctggct cctggtcctt ttctgcttgg catgttatcc 3300 cagttgccac gctgtcagtc ctccgtgcca gccctcgccc accccacgcg cctacattac 3360 ctcctgcgcc tactgacctt ccttctgggt ccagggactg ggggtgccga gacgcagggg 3420 atgttaggtc aagccctgct gctctctagt ctcccagaca actgttcatt ctgggatgcc 3480 ttccgcccag agggccggag aagtgtactg aggacagtcg gagagtactt gcagcgggaa 3540 gagccaaccc caccaggctt agactcctcc ctcagcctcg gctctggtat gagcaagatg 3600 gagcttctgt cctgcttcag tcctgtactg tgggatctac tccagagaga gaagagcgtt 3660 tgggccctga ggaccctggt gaaggcctac ctgcgcatgc ctccagaaga ccttcagcag 3720 cttgtgcttt cagcagagat ggaggctgca cagggcttcc tgacgctcat gcttcgttcc 3780 tgggctaagc tgaaggttca accatccgag gagcaggcca tgggccgcct gacagccttg 3840 ctgctccagc ggtacccacg cctcacctcc caactcttta tcgacatgtc accgctcatc 3900 cccttcctgg ctgtccctga cctcatgcgc ttcccaccgt cccttttggc caacgacagt 3960 gtcctggctg ccatcaggga tcacagctca ggaatgaagc ctgaacagaa ggaggccctg 4020 gcaaaacgac tgctggcccc tgagctgttt ggagaagtgc ctgattggcc ccaggagctg 4080 ctgtgggcag ccctgcctct gcttccccat ctgcctctgg agagctttct ccagctcagc 4140 cctcaccaga tccaggccct ggaggatagc tggccagtag cagatcttgg gccgggacac 4200 gcccgacatg tgcttcgtag cctagtaaac cagagcatgg aggatgggga ggagcaggtg 4260 ctcaggcttg ggtccctcgc ctgtttcctg agtcctgagg agctacagag tctggtgccc 4320 ttgagtgatc caatggggcc tgtagaacag ggtctgctgg aatgtgcggc caatgggacc 4380 ctcagcccag aaggacgggt ggcatatgaa cttctgggag tgttgcgttc atctggagga 4440 actgtcttaa gcccccgaga gctgagggtc tgggcacctc tctttcccca gctgggcctc 4500 cgcttcctgc aggagctctc agagacccag cttagagcca tgcttcctgc cctacaggga 4560 gccagtgtca caccctcgag ttaagggcga attcccgata aggatcttcc tagagcatgg 4620 ctacgtagat aagtagcatg gcgggttaat cattaactac aaggaacccc tagtgatgga 4680 gttggccact ccctctctgc gcgctcgctc gctcactgag gccgggcgac caaaggtcgc 4740 ccgacgcccg ggctttgccc gggcggcctc agtgagcgag cgagcgcgca gccttaatta 4800 acctaattca ctggccgtcg ttttacaacg tcgtgactgg gaaaaccctg gcgttaccca 4860 acttaatcgc cttgcagcac atcccccttt cgccagctgg cgtaatagcg aagaggcccg 4920 caccgatcgc ccttcccaac agttgcgcag cctgaatggc gaatgggacg cgccctgtag 4980 cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag 5040 cgccctagcg cccgctcctt tcgctttctt cccttccttt ctcgccacgt tcgccggctt 5100 tccccgtcaa gctctaaatc gggggctccc tttagggttc cgatttagtg ctttacggca 5160 cctcgacccc aaaaaacttg attagggtga tggttcacgt agtgggccat cgccctgata 5220 gacggttttt cgccctttga cgttggagtc cacgttcttt aatagtggac tcttgttcca 5280 aactggaaca acactcaacc ctatctcggt ctattctttt gatttataag ggattttgcc 5340 gatttcggcc tattggttaa aaaatgagct gatttaacaa aaatttaacg cgaattttaa 5400 caaaatatta acgcttacaa tttaggtggc acttttcggg gaaatgtgcg cggaacccct 5460 atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca ataaccctga 5520 taaatgcttc aataatattg aaaaaggaag agtatgagcc atattcaacg ggaaacgtcg 5580 aggccgcgat taaattccaa catggatgct gatttatatg ggtataaatg ggctcgcgat 5640 aatgtcgggc aatcaggtgc gacaatctat cgcttgtatg ggaagcccga tgcgccagag 5700 ttgtttctga aacatggcaa aggtagcgtt gccaatgatg ttacagatga gatggtcaga 5760 ctaaactggc tgacggaatt tatgcctctt ccgaccatca agcattttat ccgtactcct 5820 gatgatgcat ggttactcac cactgcgatc cccggaaaaa cagcattcca ggtattagaa 5880 gaatatcctg attcaggtga aaatattgtt gatgcgctgg cagtgttcct gcgccggttg 5940 cattcgattc ctgtttgtaa ttgtcctttt aacagcgatc gcgtatttcg tcttgctcag 6000 gcgcaatcac gaatgaataa cggtttggtt gatgcgagtg attttgatga cgagcgtaat 6060 ggctggcctg ttgaacaagt ctggaaagaa atgcataaac ttttgccatt ctcaccggat 6120 tcagtcgtca ctcatggtga tttctcactt gataacctta tttttgacga ggggaaatta 6180 ataggttgta ttgatgttgg acgagtcgga atcgcagacc gataccagga tcttgccatc 6240 ctatggaact gcctcggtga gttttctcct tcattacaga aacggctttt tcaaaaatat 6300 ggtattgata atcctgatat gaataaattg cagtttcatt tgatgctcga tgagtttttc 6360 taactgtcag accaagttta ctcatatata ctttagattg atttaaaact tcatttttaa 6420 tttaaaagga tctaggtgaa gatccttttt gataatctca tgaccaaaat cccttaacgt 6480 gagttttcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat 6540 cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct accagcggtg 6600 gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg cttcagcaga 6660 gcgcagatac caaatactgt tcttctagtg tagccgtagt taggccacca cttcaagaac 6720 tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc tgctgccagt 6780 ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga taaggcgcag 6840 cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac gacctacacc 6900 gaactgagat acctacagcg tgagctatga gaaagcgcca cgcttcccga agggagaaag 6960 gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag ggagcttcca 7020 gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg acttgagcgt 7080 cgatttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag caacgcggcc 7140 tttttacggt tcctggcctt ttgctggcct tttgctcaca tgttctttcc tgcgttatcc 7200 cctgattctg tggataaccg tattaccgcc tttgagtgag ctgataccgc tcgccgcagc 7260 cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg aagagcgccc aatacgcaaa 7320 ccgcctctcc ccgcgcgttg gccgattcat taatgcagct ggcacgacag gtttcccgac 7380 tggaaagcgg gcagtgagcg caacgcaatt aatgtgagtt agctcactca ttaggcaccc 7440 caggctttac actttatgct tccggctcgt atgttgtgtg gaattgtgag cggataacaa 7500 tttcacacag gaaacagcta tgaccatgat tacgccagat ttaattaagg ccttaattag 7560 g 7561 <210> 44 <211> 7206 <212> ADN <213> Secuencia artificial <220> <223> Construcción sintética <400> 44 ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt 60 ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact 120 aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct 180 aggaagatcg gaattcgccc ttaagctagc gcctcggctc tggtatgagc aagatggagc 240 ttctgtcctg cttcagtcct gtactgtggg atctactcca gagagagaag agcgtttggg 300 ccctgaggac cctggtgaag gcctacctgc gcatgcctcc agaagacctt cagcagcttg 360 tgctttcagc agagatggag gctgcacagg gcttcctgac gctcatgctt cgttcctggg 420 ctaagctgaa ggttcaacca tccgaggagc aggccatggg ccgcctgaca gccttgctgc 480 tccagcggta cccacgcctc acctcccaac tctttatcga catgtcaccg ctcatcccct 540 tcctggctgt ccctgacctc atgcgcttcc caccgtccct tttggccaac gacagtgtcc 600 tggctgccat cagggatcac agctcaggaa tgaagcctga acagaaggag gccctggcaa 660 aacgactgct ggcccctgag ctgtttggag aagtgcctga ttggccccag gagctgctgt 720 gggcagccct gcctctgctt ccccatctgc ctctggagag ctttctccag ctcagccctc 780 accagatcca ggccctggag gatagctggc cagtagcaga tcttgggccg ggacacgccc 840 gacatgtgct tcgtagccta gtaaaccaga gcatggagga tggggaggag caggtgctca 900 ggcttgggtc cctcgcctgt ttcctgagtc ctgaggagct acagagtctg gtgcccttga 960 gtgatccaat ggggcctgta gaacagggtc tgctggaatg tgcggccaat gggaccctca 1020 gcccagaagg acgggtggca tatgaacttc tgggagtgtt gcgttcatct ggaggaactg 1080 tcttaagccc ccgagagctg agggtctggg cacctctctt tccccagctg ggcctccgct 1140 tcctgcagga gctctcagag acccagctta gagccatgct tcctgcccta cagggagcca 1200 gtgtcacacc tgcccaggct gttctgttgt ttggaaggct ccttcctaag catgatctgt 1260 ccctggagga actctgctcc ctgcaccctc tcctgccagg tctcagcccc cagacactcc 1320 aggccatccc taagagagtt ctggttggtg cttgttcctg cctgggccct gaactgtcaa 1380 ggctttcagc ttgccagatt gcagctctgc tgcagacctt tcgggtaaaa gatggtgtta 1440 aaaatatggg tgcagcaggt gccggctcag ccgtgtgcat tcctgggcag cccaccactt 1500 ggccagactg cctgcttccc ctgctcccat taaagctgct acagctggac gctgcagctc 1560 ttctggcaaa ccgaagactc tatcggcagc tgccttggtc tgagcaacag gcacagtttc 1620 tctggaagaa aatgcaagtg cctaccaacc tgagcctgag gaatctgcag gctctgggca 1680 acttggcagg aggcatgacc tgcgagtttc tgcagcagat cagctcaatg gttgactttc 1740 ttgatgtggt acacatgctc taccagctgc ccactggtgt tcgagagagc ctgcgggcct 1800 gtatctggac agagctacag cggaggatga caatgccaga gccagagctg accaccctag 1860 ggccagaact gagtgaactt gacacaaagc tactcctgga cttgccgatc cagctgatgg 1920 acagattgtc caatgattcc attatgttgg tggtggagat ggtccaaggc gctccagagc 1980 agctgctggc actgacccca ctccaccaga cagccttggc agagcgagca cttaaaaacc 2040 tggctccaaa ggagacccca atctccaaag aagtgctgga gacactgggc cccttggttg 2100 gattcctggg aatagagagc acgcgacgga tccctttacc cattctactg tctcatctca 2160 gtcagctgca gggcttctgc ctaggagaga catttgccac agagctggga tggctgctgt 2220 tgcaggagcc tgttcttgga aaaccagaat tgtggagcca ggatgaaata gagcaagctg 2280 gacgcctagt attcactctg tctgctgagg ctatttcctc gatccccagg gaggctttgg 2340 gcccagagac actggagagg cttctgggaa agcatcaaag ctgggagcag agcagagtgg 2400 gccatctgtg tggggagtca cagcttgccc acaagaaagc agctctggta gctgggattg 2460 tgcatccagc tgctgagggt ctccaagagc ctgtaccaaa ctgtgcagac atacggggaa 2520 ccttcccagc ggcctggtct gcgacacaaa tctcagagat ggaactctca gactttgaag 2580 actgcctgtc actatttgct ggagatccag gacttggtcc tgaggaacta cgggcagcca 2640 tgggcaaggc caagcagttg tggggtcccc ctcgaggatt ccgtcctgag cagatcttgc 2700 agctgggccg tctcctgata ggtctaggag aacgggaact gcaggagctt accttggtgg 2760 actggggtgt gctgagcagc ctggggcaaa tagatggctg gagttccatg cagctccgag 2820 ccgtggtctc cagtttccta aggcagagtg gtcggcatgt gagccacctg gacttcattt 2880 atctgacagc actgggttac acagtctgtg gattgcgacc agaggagtta cagcacatca 2940 gcagttggga gtttagccaa gcagctctct tcctgggtag cttgcatctc ccgtgctctg 3000 aggaacagct ggaagttctg gcctatctcc ttgtgttgcc tggtggcttt ggcccagtca 3060 gtaactgggg gcctgagatc ttcactgaaa ttggcacaat agcagctggc atcccagacc 3120 tggctctttc agcattactg cggggacaga tccaaggcct gactcctctt gccatttctg 3180 tcattcctgc tcccaagttt gcagtggtct tcaaccccat ccagttatct agtctcacca 3240 ggggtcaggc cgtagctgtt actcctgaac agctggccta tctgagtcct gagcagcggc 3300 gagcagttgc atgggcccaa cacgaaggga aggagatccc agagcagctg ggtcgaaact 3360 cagcctgggg tctctacgac tggttccaag cctcctgggc cctggcattg cccgtcagca 3420 tttttggcca cctattatga taataagctt ggatccaatc aacctctgga ttacaaaatt 3480 tgtgaaagat tgactggtat tcttaactat gttgctcctt ttacgctatg tggatacgct 3540 gctttaatgc ctttgtatca tgctattgct tcccgtatgg ctttcatttt ctcctccttg 3600 tataaatcct ggttgctgtc tctttatgag gagttgtggc ccgttgtcag gcaacgtggc 3660 gtggtgtgca ctgtgtttgc tgacgcaacc cccactggtt ggggcattgc caccacctgt 3720 cagctccttt ccgggacttt cgctttcccc ctccctattg ccacggcgga actcatcgcc 3780 gcctgccttg cccgctgctg gacaggggct cggctgttgg gcactgacaa ttccgtggtg 3840 ttgtcgggga aatcatcgtc ctttccttgg ctgctcgcct gtgttgccac ctggattctg 3900 cgcgggacgt ccttctgcta cgtcccttcg gccctcaatc cagcggacct tccttcccgc 3960 ggcctgctgc cggctctgcg gcctcttccg cgtcttcgag atctgcctcg actgtgcctt 4020 ctagttgcca gccatctgtt gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg 4080 ccactcccac tgtcctttcc taataaaatg aggaaattgc atcgcattgt ctgagtaggt 4140 gtcattctat tctggggggt ggggtggggc aggacagcaa gggggaggat tgggaagaca 4200 atagcaggca tgctggggac tcgagttaag ggcgaattcc cgataaggat cttcctagag 4260 catggctacg tagataagta gcatggcggg ttaatcatta actacaagga acccctagtg 4320 atggagttgg ccactccctc tctgcgcgct cgctcgctca ctgaggccgg gcgaccaaag 4380 gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc gcgcagcctt 4440 aattaaccta attcactggc cgtcgtttta caacgtcgtg actgggaaaa ccctggcgtt 4500 acccaactta atcgccttgc agcacatccc cctttcgcca gctggcgtaa tagcgaagag 4560 gcccgcaccg atcgcccttc ccaacagttg cgcagcctga atggcgaatg ggacgcgccc 4620 tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc gcagcgtgac cgctacactt 4680 gccagcgccc tagcgcccgc tcctttcgct ttcttccctt cctttctcgc cacgttcgcc 4740 ggctttcccc gtcaagctct aaatcggggg ctccctttag ggttccgatt tagtgcttta 4800 cggcacctcg accccaaaaa acttgattag ggtgatggtt cacgtagtgg gccatcgccc 4860 tgatagacgg tttttcgccc tttgacgttg gagtccacgt tctttaatag tggactcttg 4920 ttccaaactg gaacaacact caaccctatc tcggtctatt cttttgattt ataagggatt 4980 ttgccgattt cggcctattg gttaaaaaat gagctgattt aacaaaaatt taacgcgaat 5040 tttaacaaaa tattaacgct tacaatttag gtggcacttt tcggggaaat gtgcgcggaa 5100 cccctatttg tttatttttc taaatacatt caaatatgta tccgctcatg agacaataac 5160 cctgataaat gcttcaataa tattgaaaaa ggaagagtat gagccatatt caacgggaaa 5220 cgtcgaggcc gcgattaaat tccaacatgg atgctgattt atatgggtat aaatgggctc 5280 gcgataatgt cgggcaatca ggtgcgacaa tctatcgctt gtatgggaag cccgatgcgc 5340 cagagttgtt tctgaaacat ggcaaaggta gcgttgccaa tgatgttaca gatgagatgg 5400 tcagactaaa ctggctgacg gaatttatgc ctcttccgac catcaagcat tttatccgta 5460 ctcctgatga tgcatggtta ctcaccactg cgatccccgg aaaaacagca ttccaggtat 5520 tagaagaata tcctgattca ggtgaaaata ttgttgatgc gctggcagtg ttcctgcgcc 5580 ggttgcattc gattcctgtt tgtaattgtc cttttaacag cgatcgcgta tttcgtcttg 5640 ctcaggcgca atcacgaatg aataacggtt tggttgatgc gagtgatttt gatgacgagc 5700 gtaatggctg gcctgttgaa caagtctgga aagaaatgca taaacttttg ccattctcac 5760 cggattcagt cgtcactcat ggtgatttct cacttgataa ccttattttt gacgagggga 5820 aattaatagg ttgtattgat gttggacgag tcggaatcgc agaccgatac caggatcttg 5880 ccatcctatg gaactgcctc ggtgagtttt ctccttcatt acagaaacgg ctttttcaaa 5940 aatatggtat tgataatcct gatatgaata aattgcagtt tcatttgatg ctcgatgagt 6000 ttttctaact gtcagaccaa gtttactcat atatacttta gattgattta aaacttcatt 6060 tttaatttaa aaggatctag gtgaagatcc tttttgataa tctcatgacc aaaatccctt 6120 aacgtgagtt ttcgttccac tgagcgtcag accccgtaga aaagatcaaa ggatcttctt 6180 gagatccttt ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag 6240 cggtggtttg tttgccggat caagagctac caactctttt tccgaaggta actggcttca 6300 gcagagcgca gataccaaat actgttcttc tagtgtagcc gtagttaggc caccacttca 6360 agaactctgt agcaccgcct acatacctcg ctctgctaat cctgttacca gtggctgctg 6420 ccagtggcga taagtcgtgt cttaccgggt tggactcaag acgatagtta ccggataagg 6480 cgcagcggtc gggctgaacg gggggttcgt gcacacagcc cagcttggag cgaacgacct 6540 acaccgaact gagataccta cagcgtgagc tatgagaaag cgccacgctt cccgaaggga 6600 gaaaggcgga caggtatccg gtaagcggca gggtcggaac aggagagcgc acgagggagc 6660 ttccaggggg aaacgcctgg tatctttata gtcctgtcgg gtttcgccac ctctgacttg 6720 agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac gccagcaacg 6780 cggccttttt acggttcctg gccttttgct ggccttttgc tcacatgttc tttcctgcgt 6840 tatcccctga ttctgtggat aaccgtatta ccgcctttga gtgagctgat accgctcgcc 6900 gcagccgaac gaccgagcgc agcgagtcag tgagcgagga agcggaagag cgcccaatac 6960 gcaaaccgcc tctccccgcg cgttggccga ttcattaatg cagctggcac gacaggtttc 7020 ccgactggaa agcgggcagt gagcgcaacg caattaatgt gagttagctc actcattagg 7080 caccccaggc tttacacttt atgcttccgg ctcgtatgtt gtgtggaatt gtgagcggat 7140 aacaatttca cacaggaaac agctatgacc atgattacgc cagatttaat taaggcctta 7200 attagg 7206 <210> 45 <211> 7447 <212> ADN <213> Secuencia artificial <220> <223> Construcción sintética <400> 45 ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt 60 ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact 120 aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct 180 aggaagatcg gaattcgccc ttaagctagc ggcgcgccac cggtagcagg tttgttacag 240 aaaccttagt taaggtttgt tgagggtttt ttttctctct ctctctctta attggctgtc 300 ccaatccatc cttctataaa tagaaaagag agacagggag tgtgtgtggt ttcattacta 360 aggtaaagac acttgagcta cacacacttg atccctgaac atgaaatcta agaggttgaa 420 cgatcacagt ttcaggacta tataaggtgg tgaaagacca tctgcttcgt ttttctgttt 480 gttcctacaa ctctttccct ccgcttgatt ttaactctaa attggtgagt agctggtggg 540 ctcaccagac tccgagatcc tcttctctgc acgcactgta ttagacttgg cacccgggag 600 gattttcacc tctgctgcat gggctaatct tccacaaggg atctgtggta ttgcaatctc 660 gggttgatgc atgacggtga tgttgtgttt atagcatggc taaggtttag ctgcctatga 720 tgattggtta gggaaggata atttttgcta gaagattgga ctttagggaa aaaaaacccc 780 acttttattt gcttttagaa ttttaaaaga ctgggccatg tagctcaggc tggtttggag 840 ttcattatgt agtcaaggat gctcttggac tctttagcat cctcctcctc ctctttttcc 900 tcctcctcct tcttgttctt cttcttgttc ttcctcttcc ccttctcttc ccccttctct 960 ccctcttcct cctcttcctc ctccttcttg ttcttcttcc tcttcccctt ctcctctccc 1020 ccttgtcctc ctcttccttc tcctcctcct cctcttcttc tttctgagta ccaagattgc 1080 aagtgtgcac acgatgacca gcttggtctt tctttgtctt ttttttttaa cttcaatttt 1140 ggagtgaatt caagagcaac catgtagtca agaggtggct ggagtctttt ctgtatctgg 1200 gtttggttta gtactctgcc ccatcactta acaggtcctt atggccacat cttaaaaaaa 1260 ttctagagat acacggtgtc ggtgagtggc tgagaatgtg tggtcttccc atttctctgt 1320 caccgtggct cacatcttgt ttcctctgtt cggccaggta gaaaggcggc cgccaccatg 1380 gctctgagcc tccagcccca gctgctcctt ctcctgtcgc tcctgccgca ggaagtgact 1440 tcagccccta ctgggcctca gtctttggat gctggtctct cccttctgaa gtcattcgta 1500 gccactctgg accaagctcc tcagcgttcc ctcagccagt cacggttctc tgcgttcctg 1560 gccaacattt cttcatcctt ccagcttggg aggatggggg agggaccggt gggagagccc 1620 ccacctctcc agccccctgc acttcgactt catgatttcc tcgtgacact gagaggtagc 1680 ccagactggg agccaatgct agggcttctg ggagatgtgc tggcactcct gggacaggaa 1740 cagactcccc gggacttttt ggtgcaccag gcaggtgtac tgggtggact tgtagaggca 1800 ttgttgggag cgttagttcc tggaggcccc cctgccccca ctcgaccccc atgcacccgt 1860 gatggccctt ctgactgtgt cctggctgct gattggttgc cttctctgat gttgttatta 1920 gagggtacac gctggcaggc cctggtgcag ttgcagccca gtgtggaccc aaccaatgcc 1980 acaggtcttg atggtagaga gccagctcct cactttttac agggtctgct gggcttgctt 2040 accccagcag gagagttggg ctctgaggag gctctttggg gtggtctgct gcgcacagtg 2100 ggggcccccc tctatgctgc cttccaggag gggctactgc gagtcactca ttctctgcaa 2160 gatgaggtct tttctattat gggacagcca gagcctgatg ccagtgggca gtgccaggga 2220 ggcaaccttc aacagctgct tttatggggc atgcggaaca acctttcttg ggacgcccga 2280 gcactgggtt ttctatctgg atcaccacct ccaccccctg ctctcctgca ctgcctgagc 2340 agaggtgtgc ctctgcccag ggcttcccag cctgcggctc acatcagccc tcgacagcgg 2400 cgagccatct ctgtggaggc cctctgcgag aaccactcag gcccagagcc accctacagc 2460 atctccaact tctccatcta cttgctctgc cagcacatca agcctgccac cccgcggccc 2520 cctcctacca ccccacggcc tcctcctacc accccacagc cccctcctac cactacacag 2580 cccattcctg acactacaca gccccctcct gtcaccccaa ggcctcctcc taccacccca 2640 caaccccctc ctagcacagc tgtcatctgc cagacagctg tatggtacgc agtctcgtgg 2700 gcaccaggtg cccgaggttg gctccaagcc tgccatgatc agtttcctga tcaatttctg 2760 gatatgatct gcggcaacct ctcattttca gccctgtctg gccccagtcg tcctttggta 2820 aagcagctct gtgctggctt gctcccaccc cccactagct gtccaccagg cctgatccct 2880 gtgcccctca ccccagaaat attctggggc tgtttcctgg agaatgagac actgtgggct 2940 gaacggttgt gtgtggagga cagtctgcag gctgtgcccc cgaggaacca ggcttgggtt 3000 cagcatgtgt gtcggggccc caccttggac gccactgatt ttccaccgtg ccgcgttgga 3060 ccctgtgggg aacgctgccc agatgggggc agcttcctgc tcatggtctg tgccaatgac 3120 actctgtatg aagccttggt tcccttctgg gcttggctag caggccaatg cagaattagt 3180 cgtggaggaa atgatacttg ctttctagaa ggcatgctgg gccccttgtt gccctctctg 3240 ccccctctgg gaccatcccc actctgtctg gctcctggtc cttttctgct tggcatgtta 3300 tcccagttgc cacgctgtca gtcctccgtg ccagccctcg cccaccccac gcgcctacat 3360 tacctcctgc gcctactgac cttccttctg ggtccaggga ctgggggtgc cgagacgcag 3420 gggatgttag gtcaagccct gctgctctct agtctcccag acaactgttc attctgggat 3480 gccttccgcc cagagggccg gagaagtgta ctgaggacag tcggagagta cttgcagcgg 3540 gaagagccaa ccccaccagg cttagactcc tccctcagcc tcggctctgg tatgagcaag 3600 atggagcttc tgtcctgctt cagtcctgta ctgtgggatc tactccagag agagaagagc 3660 gtttgggccc tgaggaccct ggtgaaggcc tacctgcgca tgcctccaga agaccttcag 3720 cagcttgtgc tttcagcaga gatggaggct gcacagggct tcctgacgct catgcttcgt 3780 tcctgggcta agctgaaggt tcaaccatcc gaggagcagg ccatgggccg cctgacagcc 3840 ttgctgctcc agcggtaccc acgcctcacc tcccaactct ttatcgacat gtcaccgctc 3900 atccccttcc tggctgtccc tgacctcatg cgcttcccac cgtccctttt ggccaacgac 3960 agtgtcctgg ctgccatcag ggatcacagc tcaggaatga agcctgaaca gaaggaggcc 4020 ctggcaaaac gactgctggc ccctgagctg tttggagaag tgcctgattg gccccaggta 4080 agtatcaagg ttacaagaca ggtttaagga gaccaataga aactgggctt gtcgagacag 4140 agaagactct tgcgtttctg agctagcccc cgggtgcgcg gcgtcggtgg tgccggcggg 4200 gggcgccagg tcgcaggcgg tgtagggctc caggcaggcg gcgaaggcca tgacgtgcgc 4260 tatgaaggtc tgctcctgca cgccgtgaac caggtgcgcc tgcgggccgc gcgcgaacac 4320 cgccacgtcc tcgcctgcgt gggtctcttc gtccaggggc actgctgact gctgccgata 4380 ctcggggctc ccgctctcgc tctcggtaac atccggccgg gcgccgtcct tgagcacata 4440 gcctggaccg tttcgtcgac ctcgagttaa gggcgaattc ccgataagga tcttcctaga 4500 gcatggctac gtagataagt agcatggcgg gttaatcatt aactacaagg aacccctagt 4560 gatggagttg gccactccct ctctgcgcgc tcgctcgctc actgaggccg ggcgaccaaa 4620 ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag cgcgcagcct 4680 taattaacct aattcactgg ccgtcgtttt acaacgtcgt gactgggaaa accctggcgt 4740 tacccaactt aatcgccttg cagcacatcc ccctttcgcc agctggcgta atagcgaaga 4800 ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg aatggcgaat gggacgcgcc 4860 ctgtagcggc gcattaagcg cggcgggtgt ggtggttacg cgcagcgtga ccgctacact 4920 tgccagcgcc ctagcgcccg ctcctttcgc tttcttccct tcctttctcg ccacgttcgc 4980 cggctttccc cgtcaagctc taaatcgggg gctcccttta gggttccgat ttagtgcttt 5040 acggcacctc gaccccaaaa aacttgatta gggtgatggt tcacgtagtg ggccatcgcc 5100 ctgatagacg gtttttcgcc ctttgacgtt ggagtccacg ttctttaata gtggactctt 5160 gttccaaact ggaacaacac tcaaccctat ctcggtctat tcttttgatt tataagggat 5220 tttgccgatt tcggcctatt ggttaaaaaa tgagctgatt taacaaaaat ttaacgcgaa 5280 ttttaacaaa atattaacgc ttacaattta ggtggcactt ttcggggaaa tgtgcgcgga 5340 acccctattt gtttattttt ctaaatacat tcaaatatgt atccgctcat gagacaataa 5400 ccctgataaa tgcttcaata atattgaaaa aggaagagta tgagccatat tcaacgggaa 5460 acgtcgaggc cgcgattaaa ttccaacatg gatgctgatt tatatgggta taaatgggct 5520 cgcgataatg tcgggcaatc aggtgcgaca atctatcgct tgtatgggaa gcccgatgcg 5580 ccagagttgt ttctgaaaca tggcaaaggt agcgttgcca atgatgttac agatgagatg 5640 gtcagactaa actggctgac ggaatttatg cctcttccga ccatcaagca ttttatccgt 5700 actcctgatg atgcatggtt actcaccact gcgatccccg gaaaaacagc attccaggta 5760 ttagaagaat atcctgattc aggtgaaaat attgttgatg cgctggcagt gttcctgcgc 5820 cggttgcatt cgattcctgt ttgtaattgt ccttttaaca gcgatcgcgt atttcgtctt 5880 gctcaggcgc aatcacgaat gaataacggt ttggttgatg cgagtgattt tgatgacgag 5940 cgtaatggct ggcctgttga acaagtctgg aaagaaatgc ataaactttt gccattctca 6000 ccggattcag tcgtcactca tggtgatttc tcacttgata accttatttt tgacgagggg 6060 aaattaatag gttgtattga tgttggacga gtcggaatcg cagaccgata ccaggatctt 6120 gccatcctat ggaactgcct cggtgagttt tctccttcat tacagaaacg gctttttcaa 6180 aaatatggta ttgataatcc tgatatgaat aaattgcagt ttcatttgat gctcgatgag 6240 tttttctaac tgtcagacca agtttactca tatatacttt agattgattt aaaacttcat 6300 ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac caaaatccct 6360 taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa aggatcttct 6420 tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca 6480 gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt aactggcttc 6540 agcagagcgc agataccaaa tactgttctt ctagtgtagc cgtagttagg ccaccacttc 6600 aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc agtggctgct 6660 gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt accggataag 6720 gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga gcgaacgacc 6780 tacaccgaac tgagatacct acagcgtgag ctatgagaaa gcgccacgct tcccgaaggg 6840 agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg cacgagggag 6900 cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca cctctgactt 6960 gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac 7020 gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt ctttcctgcg 7080 ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga taccgctcgc 7140 cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga gcgcccaata 7200 cgcaaaccgc ctctccccgc gcgttggccg attcattaat gcagctggca cgacaggttt 7260 cccgactgga aagcgggcag tgagcgcaac gcaattaatg tgagttagct cactcattag 7320 gcaccccagg ctttacactt tatgcttccg gctcgtatgt tgtgtggaat tgtgagcgga 7380 taacaatttc acacaggaaa cagctatgac catgattacg ccagatttaa ttaaggcctt 7440 aattagg 7447 <210> 46 <211> 6573 <212> ADN <213> Secuencia artificial <220> <223> Construcción sintética <400> 46 ccttaattag gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc 60 gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca 120 actccatcac taggggttcc ttgtagttaa tgattaaccc gccatgctac ttatctacgt 180 agccatgctc taggaagatc ggaattcgcc cttaagctag cggcgcgccc aattggcttc 240 gaattctagc ggccgccccc gggtgcgcgg cgtcggtggt gccggcgggg ggcgccaggt 300 cgcaggcggt gtagggctcc aggcaggcgg cgaaggccat gacgtgcgct atgaaggtct 360 gctcctgcac gccgtgaacc aggtgcgcct gcgggccgcg cgcgaacacc gccacgtcct 420 cgcctgcgtg ggtctcttcg tccaggggca ctgctgactg ctgccgatac tcggggctcc 480 cgctctcgct ctcggtaaca tccggccggg cgccgtcctt gagcacatag cctggaccgt 540 ttccttaagc gacgcatgct cgcgataggc acctattggt cttactgaca tccactttgc 600 ctttctctcc acaggagctg ctgtgggcag ccctgcctct gcttccccat ctgcctctgg 660 agagctttct ccagctcagc cctcaccaga tccaggccct ggaggatagc tggccagtag 720 cagatcttgg gccgggacac gcccgacatg tgcttcgtag cctagtaaac cagagcatgg 780 aggatgggga ggagcaggtg ctcaggcttg ggtccctcgc ctgtttcctg agtcctgagg 840 agctacagag tctggtgccc ttgagtgatc caatggggcc tgtagaacag ggtctgctgg 900 aatgtgcggc caatgggacc ctcagcccag aaggacgggt ggcatatgaa cttctgggag 960 tgttgcgttc atctggagga actgtcttaa gcccccgaga gctgagggtc tgggcacctc 1020 tctttcccca gctgggcctc cgcttcctgc aggagctctc agagacccag cttagagcca 1080 tgcttcctgc cctacaggga gccagtgtca cacctgccca ggctgttctg ttgtttggaa 1140 ggctccttcc taagcatgat ctgtccctgg aggaactctg ctccctgcac cctctcctgc 1200 caggtctcag cccccagaca ctccaggcca tccctaagag agttctggtt ggtgcttgtt 1260 cctgcctggg ccctgaactg tcaaggcttt cagcttgcca gattgcagct ctgctgcaga 1320 cctttcgggt aaaagatggt gttaaaaata tgggtgcagc aggtgccggc tcagccgtgt 1380 gcattcctgg gcagcccacc acttggccag actgcctgct tcccctgctc ccattaaagc 1440 tgctacagct ggacgctgca gctcttctgg caaaccgaag actctatcgg cagctgcctt 1500 ggtctgagca acaggcacag tttctctgga agaaaatgca agtgcctacc aacctgagcc 1560 tgaggaatct gcaggctctg ggcaacttgg caggaggcat gacctgcgag tttctgcagc 1620 agatcagctc aatggttgac tttcttgatg tggtacacat gctctaccag ctgcccactg 1680 gtgttcgaga gagcctgcgg gcctgtatct ggacagagct acagcggagg atgacaatgc 1740 cagagccaga gctgaccacc ctagggccag aactgagtga acttgacaca aagctactcc 1800 tggacttgcc gatccagctg atggacagat tgtccaatga ttccattatg ttggtggtgg 1860 agatggtcca aggcgctcca gagcagctgc tggcactgac cccactccac cagacagcct 1920 tggcagagcg agcacttaaa aacctggctc caaaggagac cccaatctcc aaagaagtgc 1980 tggagacact gggccccttg gttggattcc tgggaataga gagcacgcga cggatccctt 2040 tacccattct actgtctcat ctcagtcagc tgcagggctt ctgcctagga gagacatttg 2100 ccacagagct gggatggctg ctgttgcagg agcctgttct tggaaaacca gaattgtgga 2160 gccaggatga aatagagcaa gctggacgcc tagtattcac tctgtctgct gaggctattt 2220 cctcgatccc cagggaggct ttgggcccag agacactgga gaggcttctg ggaaagcatc 2280 aaagctggga gcagagcaga gtgggccatc tgtgtgggga gtcacagctt gcccacaaga 2340 aagcagctct ggtagctggg attgtgcatc cagctgctga gggtctccaa gagcctgtac 2400 caaactgtgc agacatacgg ggaaccttcc cagcggcctg gtctgcgaca caaatctcag 2460 agatggaact ctcagacttt gaagactgcc tgtcactatt tgctggagat ccaggacttg 2520 gtcctgagga actacgggca gccatgggca aggccaagca gttgtggggt ccccctcgag 2580 gattccgtcc tgagcagatc ttgcagctgg gccgtctcct gataggtcta ggagaacggg 2640 aactgcagga gcttaccttg gtggactggg gtgtgctgag cagcctgggg caaatagatg 2700 gctggagttc catgcagctc cgagccgtgg tctccagttt cctaaggcag agtggtcggc 2760 atgtgagcca cctggacttc atttatctga cagcactggg ttacacagtc tgtggattgc 2820 gaccagagga gttacagcac atcagcagtt gggagtttag ccaagcagct ctcttcctgg 2880 gtagcttgca tctcccgtgc tctgaggaac agctggaagt tctggcctat ctccttgtgt 2940 tgcctggtgg ctttggccca gtcagtaact gggggcctga gatcttcact gaaattggca 3000 caatagcagc tggcatccca gacctggctc tttcagcatt actgcgggga cagatccaag 3060 gcctgactcc tcttgccatt tctgtcattc ctgctcccaa gtttgcagtg gtcttcaacc 3120 ccatccagtt atctagtctc accaggggtc aggccgtagc tgttactcct gaacagctgg 3180 cctatctgag tcctgagcag cggcgagcag ttgcatgggc ccaacacgaa gggaaggaga 3240 tcccagagca gctgggtcga aactcagcct ggggtctcta cgactggttc caagcctcct 3300 gggccctggc attgcccgtc agcatttttg gccacctatt atgagcggcc gcggtaccaa 3360 gggcggatcc tgcatagagc tcgctgatca gcctcgactg tgccttctag ttgccagcca 3420 tctgttgttt gcccctcccc cgtgccttcc ttgaccctgg aaggtgccac tcccactgtc 3480 ctttcctaat aaaatgagga aattgcatcg cattgtctga gtaggtgtca ttctattctg 3540 gggggtgggg tggggcagga cagcaagggg gaggattggg aagacaatag caggcatctc 3600 gagttaaggg cgaattcccg ataaggatct tcctagagca tggctacgta gataagtagc 3660 atggcgggtt aatcattaac tacaaggaac ccctagtgat ggagttggcc actccctctc 3720 tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg 3780 cccgggcggc ctcagtgagc gagcgagcgc gcagccttaa ttaacctaat tcactggccg 3840 tcgttttaca acgtcgtgac tgggaaaacc ctggcgttac ccaacttaat cgccttgcag 3900 cacatccccc tttcgccagc tggcgtaata gcgaagaggc ccgcaccgat cgcccttccc 3960 aacagttgcg cagcctgaat ggcgaatggg acgcgccctg tagcggcgca ttaagcgcgg 4020 cgggtgtggt ggttacgcgc agcgtgaccg ctacacttgc cagcgcccta gcgcccgctc 4080 ctttcgcttt cttcccttcc tttctcgcca cgttcgccgg ctttccccgt caagctctaa 4140 atcgggggct ccctttaggg ttccgattta gtgctttacg gcacctcgac cccaaaaaac 4200 ttgattaggg tgatggttca cgtagtgggc catcgccctg atagacggtt tttcgccctt 4260 tgacgttgga gtccacgttc tttaatagtg gactcttgtt ccaaactgga acaacactca 4320 accctatctc ggtctattct tttgatttat aagggatttt gccgatttcg gcctattggt 4380 taaaaaatga gctgatttaa caaaaattta acgcgaattt taacaaaata ttaacgctta 4440 caatttaggt ggcacttttc ggggaaatgt gcgcggaacc cctatttgtt tatttttcta 4500 aatacattca aatatgtatc cgctcatgag acaataaccc tgataaatgc ttcaataata 4560 ttgaaaaagg aagagtatga gccatattca acgggaaacg tcgaggccgc gattaaattc 4620 caacatggat gctgatttat atgggtataa atgggctcgc gataatgtcg ggcaatcagg 4680 tgcgacaatc tatcgcttgt atgggaagcc cgatgcgcca gagttgtttc tgaaacatgg 4740 caaaggtagc gttgccaatg atgttacaga tgagatggtc agactaaact ggctgacgga 4800 atttatgcct cttccgacca tcaagcattt tatccgtact cctgatgatg catggttact 4860 caccactgcg atccccggaa aaacagcatt ccaggtatta gaagaatatc ctgattcagg 4920 tgaaaatatt gttgatgcgc tggcagtgtt cctgcgccgg ttgcattcga ttcctgtttg 4980 taattgtcct tttaacagcg atcgcgtatt tcgtcttgct caggcgcaat cacgaatgaa 5040 taacggtttg gttgatgcga gtgattttga tgacgagcgt aatggctggc ctgttgaaca 5100 agtctggaaa gaaatgcata aacttttgcc attctcaccg gattcagtcg tcactcatgg 5160 tgatttctca cttgataacc ttatttttga cgaggggaaa ttaataggtt gtattgatgt 5220 tggacgagtc ggaatcgcag accgatacca ggatcttgcc atcctatgga actgcctcgg 5280 tgagttttct ccttcattac agaaacggct ttttcaaaaa tatggtattg ataatcctga 5340 tatgaataaa ttgcagtttc atttgatgct cgatgagttt ttctaactgt cagaccaagt 5400 ttactcatat atactttaga ttgatttaaa acttcatttt taatttaaaa ggatctaggt 5460 gaagatcctt tttgataatc tcatgaccaa aatcccttaa cgtgagtttt cgttccactg 5520 agcgtcagac cccgtagaaa agatcaaagg atcttcttga gatccttttt ttctgcgcgt 5580 aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg gtggtttgtt tgccggatca 5640 agagctacca actctttttc cgaaggtaac tggcttcagc agagcgcaga taccaaatac 5700 tgttcttcta gtgtagccgt agttaggcca ccacttcaag aactctgtag caccgcctac 5760 atacctcgct ctgctaatcc tgttaccagt ggctgctgcc agtggcgata agtcgtgtct 5820 taccgggttg gactcaagac gatagttacc ggataaggcg cagcggtcgg gctgaacggg 5880 gggttcgtgc acacagccca gcttggagcg aacgacctac accgaactga gatacctaca 5940 gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca ggtatccggt 6000 aagcggcagg gtcggaacag gagagcgcac gagggagctt ccagggggaa acgcctggta 6060 tctttatagt cctgtcgggt ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc 6120 gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc 6180 cttttgctgg ccttttgctc acatgttctt tcctgcgtta tcccctgatt ctgtggataa 6240 ccgtattacc gcctttgagt gagctgatac cgctcgccgc agccgaacga ccgagcgcag 6300 cgagtcagtg agcgaggaag cggaagagcg cccaatacgc aaaccgcctc tccccgcgcg 6360 ttggccgatt cattaatgca gctggcacga caggtttccc gactggaaag cgggcagtga 6420 gcgcaacgca attaatgtga gttagctcac tcattaggca ccccaggctt tacactttat 6480 gcttccggct cgtatgttgt gtggaattgt gagcggataa caatttcaca caggaaacag 6540 ctatgaccat gattacgcca gatttaatta agg 6573 <210> 47 <211> 865 <212> ADN <213> Homo sapiens <400> 47 ccccgggtgc gcggcgtcgg tggtgccggc ggggggcgcc aggtcgcagg cggtgtaggg 60 ctccaggcag gcggcgaagg ccatgacgtg cgctatgaag gtctgctcct gcacgccgtg 120 aaccaggtgc gcctgcgggc cgcgcgcgaa caccgccacg tcctcgcctg cgtgggtctc 180 ttcgtccagg ggcactgctg actgctgccg atactcgggg ctcccgctct cgctctcggt 240 aacatccggc cgggcgccgt ccttgagcac atagcctgga ccgtttccgt ataggaggac 300 cgtgtaggcc ttcctgtccc gggccttgcc agcggccagc ccgatgaagg agctccctcg 360 cagggggtag cctccgaagg agaagacgtg ggagtggtcg gcagtgacga ggctcagcgt 420 gtcctcctcg ctggtgagct ggcccgccct ctcaatggcg tcgtcgaaca tgatcgtctc 480 agtcagtgcc cggtaagccc tgctttcatg atgaccatgg tcgatgcgac caccctccac 540 gaagaggaag aagccgcggg ggtgtctgct cagcaggcgc agggcagcct ctgtcatctc 600 catcagggag gggtccagtg tggagtctcg gtggatctcg tatttcatgt ctccaggctc 660 aaagagaccc atgagatggg tcacagacgg gtccagggaa gcctgcatga gctcagtgcg 720 gttccacacg taccgggcac cctggcgttc gccgagccat tcctgcacca gattcttccc 780 gtccagcctg gtcccacctt ggctgtagtc atctgggtac tcagggtctg gggttcccat 840 gcgaaacatg tactttcggc ctcca 865 <210> 48 <211> 437 <212> ADN <213> Homo sapiens <400> 48 ccccgggtgc gcggcgtcgg tggtgccggc ggggggcgcc aggtcgcagg cggtgtaggg 60 ctccaggcag gcggcgaagg ccatgacgtg cgctatgaag gtctgctcct gcacgccgtg 120 aaccaggtgc gcctgcgggc cgcgcgcgaa caccgccacg tcctcgcctg cgtgggtctc 180 ttcgtccagg ggcactgctg actgctgccg atactcgggg ctcccgctct cgctctcggt 240 aacatccggc cgggcgccgt ccttgagcac atagcctgga ccgtttccgt ataggaggac 300 cgtgtaggcc ttcctgtccc gggccttgcc agcggccagc ccgatgaagg agctccctcg 360 cagggggtag cctccgaagg agaagacgtg ggagtggtcg gcagtgacga ggctcagcgt 420 gtcctcctcg ctggtga 437 <210> 49 <211> 428 <212> ADN <213> Homo sapiens <400> 49 gctggcccgc cctctcaatg gcgtcgtcga acatgatcgt ctcagtcagt gcccggtaag 60 ccctgctttc atgatgacca tggtcgatgc gaccaccctc cacgaagagg aagaagccgc 120 gggggtgtct gctcagcagg cgcagggcag cctctgtcat ctccatcagg gaggggtcca 180 gtgtggagtc tcggtggatc tcgtatttca tgtctccagg ctcaaagaga cccatgagat 240 gggtcacaga cgggtccagg gaagcctgca tgagctcagt gcggttccac acgtaccggg 300 caccctggcg ttcgccgagc cattcctgca ccagattctt cccgtccagc ctggtcccac 360 cttggctgta gtcatctggg tactcagggt ctggggttcc catgcgaaac atgtactttc 420 ggcctcca 428 <210> 50 <211> 287 <212> ADN <213> Homo sapiens <400> 50 ccccgggtgc gcggcgtcgg tggtgccggc ggggggcgcc aggtcgcagg cggtgtaggg 60 ctccaggcag gcggcgaagg ccatgacgtg cgctatgaag gtctgctcct gcacgccgtg 120 aaccaggtgc gcctgcgggc cgcgcgcgaa caccgccacg tcctcgcctg cgtgggtctc 180 ttcgtccagg ggcactgctg actgctgccg atactcgggg ctcccgctct cgctctcggt 240 aacatccggc cgggcgccgt ccttgagcac atagcctgga ccgtttc 287 <210> 51 <211> 290 <212> ADN <213> Homo sapiens <400> 51 cgtataggag gaccgtgtag gccttcctgt cccgggcctt gccagcggcc agcccgatga 60 aggagctccc tcgcaggggg tagcctccga aggagaagac gtgggagtgg tcggcagtga 120 cgaggctcag cgtgtcctcc tcgctggtga gctggcccgc cctctcaatg gcgtcgtcga 180 acatgatcgt ctcagtcagt gcccggtaag ccctgctttc atgatgacca tggtcgatgc 240 gaccaccctc cacgaagagg aagaagccgc gggggtgtct gctcagcagg 290 <210> 52 <211> 288 <212> ADN <213> Homo sapiens <400> 52 cgcagggcag cctctgtcat ctccatcagg gaggggtcca gtgtggagtc tcggtggatc 60 tcgtatttca tgtctccagg ctcaaagaga cccatgagat gggtcacaga cgggtccagg 120 gaagcctgca tgagctcagt gcggttccac acgtaccggg caccctggcg ttcgccgagc 180 cattcctgca ccagattctt cccgtccagc ctggtcccac cttggctgta gtcatctggg 240 tactcagggt ctggggttcc catgcgaaac atgtactttc ggcctcca 288