LISTADO DE SECUENCIAS

<110>  INTELLIA THERAPEUTICS, INC.
 
<120>  ARN GUÍA MODIFICADOS QUE COMPRENDEN UN CONECTOR INTERNO 
       PARA MODIFICACIÓN DEL GENOMA

<130>  01155-0047-00PCT

<140>  PCT/US2022/032791
<141>  2022-06-09

<150>  US 63/275 427
<151>  2021-11-03

<150>  US 63/209 273
<151>  2021-06-10

<160>  1012  

<170>  PatentIn versión 3.5

<210>  1
<211>  80
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conectores internos L1 y L2; vea en la memoria descriptiva presentada la descripción detallada de sustituciones y modalidades preferidas
       

<400>  1
acgcaaauau caguccagcg guuuuagagc uauagcaagu uaaaauaagg cguccguuau       60

cacgggcacc gagucggugc                                                   80


<210>  2
<211>  78
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conectores internos L1 y L2; vea en la memoria descriptiva presentada la descripción detallada de sustituciones y modalidades preferidas

<400>  2
acgcaaauau caguccagcg guuuuagagc uauagcaagu uaaaauaagg cguccguuau       60

caggcaccga gucggugc                                                     78


<210>  3
<211>  78
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conectores internos L1 y L2; vea en la memoria descriptiva presentada la descripción detallada de sustituciones y modalidades preferidas

<400>  3
acgcaaauau caguccagcg guuuuagagc uagcaaguua aaauaaggcg uccguuauca       60

cgggcaccga gucggugc                                                     78


<210>  4
<211>  76
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conectores internos L1 y L2; vea en la memoria descriptiva presentada la descripción detallada de sustituciones y modalidades preferidas

<400>  4
acgcaaauau caguccagcg guuuuagagc uagcaaguua aaauaaggcg uccguuauca       60

ggcaccgagu cggugc                                                       76


<210>  5
<211>  80
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conectores internos L1 y L2; vea en la memoria descriptiva presentada la descripción detallada de sustituciones y modalidades preferidas

<400>  5
acacaaauac caguccagcg guuuuagagc uauagcaagu uaaaauaagg cguccguuau       60

cacgggcacc gagucggugc                                                   80


<210>  6
<211>  78
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conectores internos L1 y L2; vea en la memoria descriptiva presentada la descripción detallada de sustituciones y modalidades preferidas

<400>  6
acacaaauac caguccagcg guuuuagagc uauagcaagu uaaaauaagg cguccguuau       60

caggcaccga gucggugc                                                     78


<210>  7
<211>  78
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conectores internos L1 y L2; vea en la memoria descriptiva presentada la descripción detallada de sustituciones y modalidades preferidas

<400>  7
acacaaauac caguccagcg guuuuagagc uagcaaguua aaauaaggcg uccguuauca       60

cgggcaccga gucggugc                                                     78


<210>  8
<211>  76
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conectores internos L1 y L2; vea en la memoria descriptiva presentada la descripción detallada de sustituciones y modalidades preferidas

<400>  8
acacaaauac caguccagcg guuuuagagc uagcaaguua aaauaaggcg uccguuauca       60

ggcaccgagu cggugc                                                       76


<210>  9
<211>  90
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  9
acgcaaauau caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucacg aaagggcacc gagucggugc                                        90


<210>  10
<211>  90
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  10
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucacg aaagggcacc gagucggugc                                        90


<210>  11
<211>  100
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  11
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  12
<211>  100
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  12
acgcaaauau caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  13
<211>  88
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  13
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uuggcaccga gucggugc                                          88


<210>  14
<211>  88
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  14
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaca agggcaccga gucggugc                                          88


<210>  15

<400>  15
000

<210>  16
<211>  7
<212>  PRT
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  16

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  17
<211>  7
<212>  PRT
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  17

Pro Lys Lys Lys Arg Arg Val 
1               5           


<210>  18
<211>  16
<212>  PRT
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  18

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


<210>  19
<211>  7
<212>  PRT
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  19

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  20
<211>  86
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L2; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  20
acacaaauac caguccagcg guuuuagagc uaguagcaag uuaaaauaag gcuaguccgu       60

uaucaacuug gcaccgaguc ggugcu                                            86


<210>  21
<211>  85
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L2; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  21
acacaaauac caguccagcg guuuuagagc uauagcaagu uaaaauaagg cuaguccguu       60

aucaacuugg caccgagucg gugcu                                             85


<210>  22
<211>  84
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L2; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  22
acacaaauac caguccagcg guuuuagagc ugagcaaguu aaaauaaggc uaguccguua       60

ucaacuuggc accgagucgg ugcu                                              84


<210>  23
<211>  83
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L2; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  23
acacaaauac caguccagcg guuuuagagc uagcaaguua aaauaaggcu aguccguuau       60

caacuuggca ccgagucggu gcu                                               83


<210>  24
<211>  81
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L2; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  24
acacaaauac caguccagcg guuuuagagc gcaaguuaaa auaaggcuag uccguuauca       60

acuuggcacc gagucggugc u                                                 81


<210>  25
<211>  82
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L2; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  25
acacaaauac caguccagcg guuuuagagc ggcaaguuaa aauaaggcua guccguuauc       60

aacuuggcac cgagucggug cu                                                82


<210>  26
<211>  79
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L2; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  26
acacaaauac caguccagcg guuuuagagc aaguuaaaau aaggcuaguc cguuaucaac       60

uuggcaccga gucggugcu                                                    79


<210>  27
<211>  86
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L2; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  27
acacaaauac caguccagcg guuuuagagc uaguagcaag uuaaaauaag gcuaguccgu       60

uaucaacuug gcaccgaguc ggugcu                                            86


<210>  28
<211>  85
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L2; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  28
acacaaauac caguccagcg guuuuagagc uauagcaagu uaaaauaagg cuaguccguu       60

aucaacuugg caccgagucg gugcu                                             85


<210>  29
<211>  84
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L2; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  29
acacaaauac caguccagcg guuuuagagc ugagcaaguu aaaauaaggc uaguccguua       60

ucaacuuggc accgagucgg ugcu                                              84


<210>  30
<211>  83
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L2; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  30
acacaaauac caguccagcg guuuuagagc uagcaaguua aaauaaggcu aguccguuau       60

caacuuggca ccgagucggu gcu                                               83


<210>  31
<211>  82
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L2; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  31
acacaaauac caguccagcg guuuuagagc ggcaaguuaa aauaaggcua guccguuauc       60

aacuuggcac cgagucggug cu                                                82


<210>  32
<211>  81
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L2; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  32
acacaaauac caguccagcg guuuuagagc gcaaguuaaa auaaggcuag uccguuauca       60

acuuggcacc gagucggugc u                                                 81


<210>  33
<211>  79
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L2; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  33
acacaaauac caguccagcg guuuuagagc aaguuaaaau aaggcuaguc cguuaucaac       60

uuggcaccga gucggugcu                                                    79


<210>  34
<211>  87
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L2; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  34
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcguccg       60

uuaucaacuu ggcaccgagu cggugcu                                           87


<210>  35
<211>  87
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L2; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  35
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcguccg       60

uuaucaacuu ggcaccgagu cggugcu                                           87


<210>  36
<211>  87
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L2; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  36
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcguccg       60

uuaucaacuu ggcaccgagu cggugcu                                           87


<210>  37
<211>  88
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L2; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  37
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uggcaccgag ucggugcu                                          88


<210>  38
<211>  87
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L2; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  38
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac ggcaccgagu cggugcu                                           87


<210>  39
<211>  87
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L2; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  39
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaau ggcaccgagu cggugcu                                           87


<210>  40
<211>  86
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L2; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  40
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaag gcaccgaguc ggugcu                                            86


<210>  41
<211>  88
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L1; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  41
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uggcaccgag ucggugcu                                          88


<210>  42
<211>  87
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L1; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  42
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac ggcaccgagu cggugcu                                           87


<210>  43
<211>  87
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L1; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  43
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaau ggcaccgagu cggugcu                                           87


<210>  44
<211>  86
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L1; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  44
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaag gcaccgaguc ggugcu                                            86


<210>  45
<211>  83
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conectores internos L1 y L2; vea en la memoria descriptiva presentada la descripción detallada de sustituciones y modalidades preferidas

<400>  45
acacaaauac caguccagcg guuuuagagc uauagcaagu uaaaauaagg cguccguuau       60

caacuuggca ccgagucggu gcu                                               83


<210>  46
<211>  83
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L1; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  46
acacaaauac caguccagcg guuuuagagc uauagcaagu uaaaauaagg cguccguuau       60

caacuuggca ccgagucggu gcu                                               83


<210>  47
<211>  83
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conectores internos L1 y L2; vea en la memoria descriptiva presentada la descripción detallada de sustituciones y modalidades preferidas

<400>  47
acacaaauac caguccagcg guuuuagagc uauagcaagu uaaaauaagg cuaguccguu       60

aucaauggca ccgagucggu gcu                                               83


<210>  48
<211>  83
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L1; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  48
acacaaauac caguccagcg guuuuagagc uauagcaagu uaaaauaagg cuaguccguu       60

aucaauggca ccgagucggu gcu                                               83


<210>  49
<211>  81
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conectores internos L1 y L2; vea en la memoria descriptiva presentada la descripción detallada de sustituciones y modalidades preferidas

<400>  49
acacaaauac caguccagcg guuuuagagc uauagcaagu uaaaauaagg cguccguuau       60

caauggcacc gagucggugc u                                                 81


<210>  50
<211>  81
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L1; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  50
acacaaauac caguccagcg guuuuagagc uauagcaagu uaaaauaagg cguccguuau       60

caauggcacc gagucggugc u                                                 81


<210>  51
<211>  82
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conectores internos L1 y L2; vea en la memoria descriptiva presentada la descripción detallada de sustituciones y modalidades preferidas

<400>  51
acacaaauac caguccagcg guuuuagagc uaguagcaag uuaaaauaag gcguccguua       60

ucaauggcac cgagucggug cu                                                82


<210>  52
<211>  82
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L1; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  52
acacaaauac caguccagcg guuuuagagc uaguagcaag uuaaaauaag gcguccguua       60

ucaauggcac cgagucggug cu                                                82


<210>  53
<211>  79
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conectores internos L1 y L2; vea en la memoria descriptiva presentada la descripción detallada de sustituciones y modalidades preferidas

<400>  53
acacaaauac caguccagcg guuuuagagc uagcaaguua aaauaaggcg uccguuauca       60

auggcaccga gucggugcu                                                    79


<210>  54
<211>  79
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L1; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  54
acacaaauac caguccagcg guuuuagagc uagcaaguua aaauaaggcg uccguuauca       60

auggcaccga gucggugcu                                                    79


<210>  55
<211>  80
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conectores internos L1 y L2; vea en la memoria descriptiva presentada la descripción detallada de sustituciones y modalidades preferidas

<400>  55
acacaaauac caguccagcg guuuuagagc ugagcaaguu aaaauaaggc guccguuauc       60

aauggcaccg agucggugcu                                                   80


<210>  56
<211>  80
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L1; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  56
acacaaauac caguccagcg guuuuagagc ugagcaaguu aaaauaaggc guccguuauc       60

aauggcaccg agucggugcu                                                   80


<210>  57
<211>  77
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conectores internos L1 y L2; vea en la memoria descriptiva presentada la descripción detallada de sustituciones y modalidades preferidas

<400>  57
acacaaauac caguccagcg guuuuagagc gcaaguuaaa auaaggcguc cguuaucaau       60

ggcaccgagu cggugcu                                                      77


<210>  58
<211>  77
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L1; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  58
acacaaauac caguccagcg guuuuagagc gcaaguuaaa auaaggcguc cguuaucaau       60

ggcaccgagu cggugcu                                                      77


<210>  59
<211>  87
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L1; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  59
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucacg ggcaccgagu cggugcu                                           87


<210>  60
<211>  87
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L1; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  60
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucacg ggcaccgagu cggugcu                                           87


<210>  61
<211>  85
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L1; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  61
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucagg caccgagucg gugcu                                             85


<210>  62
<211>  85
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L2; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  62
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucagg caccgagucg gugcu                                             85


<210>  63
<211>  90
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  63
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucacg aaagggcacc gagucggugc                                        90


<210>  64
<211>  90
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  64
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucacg aaagggcacc gagucggugc                                        90


<210>  65
<211>  86
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L1; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  65
acacaaauac caguccagcg guuuuagagc uauagcaagu uaaaauaagg cuaguccguu       60

aucacgaaag ggcaccgagu cggugc                                            86


<210>  66
<211>  86
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L1; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  66
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucacg ggcaccgagu cggugc                                            86


<210>  67
<211>  80
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L1; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  67
acacaaauac caguccagcg guuuuagagc uauagcaagu uaaaauaagg cguccguuau       60

cacgggcacc gagucggugc                                                   80


<210>  68
<211>  82
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L1; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  68
acacaaauac caguccagcg guuuuagagc uauagcaagu uaaaauaagg cuaguccguu       60

aucacgggca ccgagucggu gc                                                82


<210>  69
<211>  86
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L2; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  69
acacaaauac caguccagcg guuuuagagc uauagcaagu uaaaauaagg cuaguccguu       60

aucacgaaag ggcaccgagu cggugc                                            86


<210>  70
<211>  88
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  70
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaaa auggcaccga gucggugc                                          88


<210>  71
<211>  88
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  71
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaaa auggcaccga gucggugc                                          88


<210>  72
<211>  84
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L1; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  72
acacaaauac caguccagcg guuuuagagc uauagcaagu uaaaauaagg cuaguccguu       60

aucaaaaugg caccgagucg gugc                                              84


<210>  73
<211>  86
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L1; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  73
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaau ggcaccgagu cggugc                                            86


<210>  74
<211>  82
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L1; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  74
acacaaauac caguccagcg guuuuagagc uauagcaagu uaaaauaagg cuaguccguu       60

aucaauggca ccgagucggu gc                                                82


<210>  75
<211>  76
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L1; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  75
acacaaauac caguccagcg guuuuagagc gcaaguuaaa auaaggcguc cguuaucaau       60

ggcaccgagu cggugc                                                       76


<210>  76

<400>  76
000

<210>  77
<211>  75
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L1 y un sitio dS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  77
ggcccagacu gagcacguga guuuuagaaa guuaaaauaa ggcuaguccg uuaucacggg       60

caccgagucg gugcu                                                        75


<210>  78
<211>  75
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conectores internos L4 y L1; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  78
ggcccagacu gagcacguga guuuuagaaa guuaaaauaa ggcuaguccg uuaucacggg       60

caccgagucg gugcu                                                        75


<210>  79
<211>  75
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conectores internos L3 y L1; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  79
ggcccagacu gagcacguga guuuuagaaa guuaaaauaa ggcuaguccg uuaucacggg       60

caccgagucg gugcu                                                        75


<210>  80
<211>  75
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conectores internos L2 y L1; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  80
ggcccagacu gagcacguga guuuuagaaa guuaaaauaa ggcuaguccg uuaucacggg       60

caccgagucg gugcu                                                        75


<210>  81
<211>  75
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L1; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  81
ggcccagacu gagcacguga guuuuagaaa guuaaaauaa ggcuaguccg uuaucacggg       60

caccgagucg gugcu                                                        75


<210>  82
<211>  79
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L1; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  82
ggcccagacu gagcacguga guuuuagagc gcaaguuaaa auaaggcuag uccguuauca       60

cgggcaccga gucggugcu                                                    79


<210>  83
<211>  83
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L1; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  83
ggcccagacu gagcacguga guuuuagagc uauagcaagu uaaaauaagg cuaguccguu       60

aucacgggca ccgagucggu gcu                                               83


<210>  84
<211>  83
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene el conector interno L1; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  84
ggcccagacu gagcacguga guuuuagagc uauagcaagu uaaaauaagg cuaguccguu       60

aucacgggca ccgagucggu gcu                                               83


<210>  85

<400>  85
000

<210>  86

<400>  86
000

<210>  87

<400>  87
000

<210>  88

<400>  88
000

<210>  89

<400>  89
000

<210>  90

<400>  90
000

<210>  91

<400>  91
000

<210>  92

<400>  92
000

<210>  93

<400>  93
000

<210>  94

<400>  94
000

<210>  95

<400>  95
000

<210>  96

<400>  96
000

<210>  97

<400>  97
000

<210>  98

<400>  98
000

<210>  99

<400>  99
000

<210>  100

<400>  100
000

<210>  101
<211>  80
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene los conectores internos L1 y L2, modificaciones 2'-O-Me y enlace PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  101
acgcaaauau caguccagcg guuuuagagc uauagcaagu uaaaauaagg cguccguuau       60

cacgggcacc gagucggugc                                                   80


<210>  102
<211>  78
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene los conectores internos L1 y L2, modificaciones 2'-O-Me y enlace PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  102
acgcaaauau caguccagcg guuuuagagc uauagcaagu uaaaauaagg cguccguuau       60

caggcaccga gucggugc                                                     78


<210>  103
<211>  78
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene los conectores internos L1 y L2, modificaciones 2'-O-Me y enlace PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  103
acgcaaauau caguccagcg guuuuagagc uagcaaguua aaauaaggcg uccguuauca       60

cgggcaccga gucggugc                                                     78


<210>  104
<211>  76
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene los conectores internos L1 y L2, modificaciones 2'-O-Me y enlace PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  104
acgcaaauau caguccagcg guuuuagagc uagcaaguua aaauaaggcg uccguuauca       60

ggcaccgagu cggugc                                                       76


<210>  105
<211>  80
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene los conectores internos L1 y L2, modificaciones 2'-O-Me y enlace PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  105
acacaaauac caguccagcg guuuuagagc uauagcaagu uaaaauaagg cguccguuau       60

cacgggcacc gagucggugc                                                   80


<210>  106
<211>  78
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene los conectores internos L1 y L2, modificaciones 2'-O-Me y enlace PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  106
acacaaauac caguccagcg guuuuagagc uauagcaagu uaaaauaagg cguccguuau       60

caggcaccga gucggugc                                                     78


<210>  107
<211>  78
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene los conectores internos L1 y L2, modificaciones 2'-O-Me y enlace PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  107
acacaaauac caguccagcg guuuuagagc uagcaaguua aaauaaggcg uccguuauca       60

cgggcaccga gucggugc                                                     78


<210>  108
<211>  76
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene los conectores internos L1 y L2, modificaciones 2'-O-Me y enlace PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  108
acacaaauac caguccagcg guuuuagagc uagcaaguua aaauaaggcg uccguuauca       60

ggcaccgagu cggugc                                                       76


<210>  109
<211>  90
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene modificaciones 2'-O-Me y enlace PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  109
acgcaaauau caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucacg aaagggcacc gagucggugc                                        90


<210>  110
<211>  90
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene modificaciones 2'-O-Me y enlace PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  110
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucacg aaagggcacc gagucggugc                                        90


<210>  111
<211>  100
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene modificaciones 2'-O-Me y enlace PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  111
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  112
<211>  100
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene modificaciones 2'-O-Me y enlace PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  112
acgcaaauau caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  113
<211>  88
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene modificaciones 2'-O-Me y enlace PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  113
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uuggcaccga gucggugc                                          88


<210>  114
<211>  88
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  114
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaca agggcaccga gucggugc                                          88


<210>  115

<400>  115
000

<210>  116

<400>  116
000

<210>  117

<400>  117
000

<210>  118

<400>  118
000

<210>  119

<400>  119
000

<210>  120
<211>  86
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L2, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  120
acacaaauac caguccagcg guuuuagagc uaguagcaag uuaaaauaag gcuaguccgu       60

uaucaacuug gcaccgaguc ggugcu                                            86


<210>  121
<211>  85
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L2 modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  121
acacaaauac caguccagcg guuuuagagc uauagcaagu uaaaauaagg cuaguccguu       60

aucaacuugg caccgagucg gugcu                                             85


<210>  122
<211>  84
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L2, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  122
acacaaauac caguccagcg guuuuagagc ugagcaaguu aaaauaaggc uaguccguua       60

ucaacuuggc accgagucgg ugcu                                              84


<210>  123
<211>  83
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L2, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  123
acacaaauac caguccagcg guuuuagagc uagcaaguua aaauaaggcu aguccguuau       60

caacuuggca ccgagucggu gcu                                               83


<210>  124
<211>  81
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L2, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  124
acacaaauac caguccagcg guuuuagagc gcaaguuaaa auaaggcuag uccguuauca       60

acuuggcacc gagucggugc u                                                 81


<210>  125
<211>  82
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L2, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  125
acacaaauac caguccagcg guuuuagagc ggcaaguuaa aauaaggcua guccguuauc       60

aacuuggcac cgagucggug cu                                                82


<210>  126
<211>  79
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L2, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  126
acacaaauac caguccagcg guuuuagagc aaguuaaaau aaggcuaguc cguuaucaac       60

uuggcaccga gucggugcu                                                    79


<210>  127
<211>  86
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  127
acacaaauac caguccagcg guuuuagagc uaguagcaag uuaaaauaag gcuaguccgu       60

uaucaacuug gcaccgaguc ggugcu                                            86


<210>  128
<211>  85
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  128
acacaaauac caguccagcg guuuuagagc uauagcaagu uaaaauaagg cuaguccguu       60

aucaacuugg caccgagucg gugcu                                             85


<210>  129
<211>  84
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  129
acacaaauac caguccagcg guuuuagagc ugagcaaguu aaaauaaggc uaguccguua       60

ucaacuuggc accgagucgg ugcu                                              84


<210>  130
<211>  83
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  130
acacaaauac caguccagcg guuuuagagc uagcaaguua aaauaaggcu aguccguuau       60

caacuuggca ccgagucggu gcu                                               83


<210>  131
<211>  82
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1 modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  131
acacaaauac caguccagcg guuuuagagc ggcaaguuaa aauaaggcua guccguuauc       60

aacuuggcac cgagucggug cu                                                82


<210>  132
<211>  81
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  132
acacaaauac caguccagcg guuuuagagc gcaaguuaaa auaaggcuag uccguuauca       60

acuuggcacc gagucggugc u                                                 81


<210>  133
<211>  79
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  133
acacaaauac caguccagcg guuuuagagc aaguuaaaau aaggcuaguc cguuaucaac       60

uuggcaccga gucggugcu                                                    79


<210>  134
<211>  87
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L4, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  134
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcguccg       60

uuaucaacuu ggcaccgagu cggugcu                                           87


<210>  135
<211>  87
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L2, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  135
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcguccg       60

uuaucaacuu ggcaccgagu cggugcu                                           87


<210>  136
<211>  87
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  136
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcguccg       60

uuaucaacuu ggcaccgagu cggugcu                                           87


<210>  137
<211>  88
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L2, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  137
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uggcaccgag ucggugcu                                          88


<210>  138
<211>  87
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L2, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  138
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac ggcaccgagu cggugcu                                           87


<210>  139
<211>  87
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L2, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  139
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaau ggcaccgagu cggugcu                                           87


<210>  140
<211>  86
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L2, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  140
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaag gcaccgaguc ggugcu                                            86


<210>  141
<211>  88
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  141
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uggcaccgag ucggugcu                                          88


<210>  142
<211>  87
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  142
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac ggcaccgagu cggugcu                                           87


<210>  143
<211>  87
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  143
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaau ggcaccgagu cggugcu                                           87


<210>  144
<211>  86
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  144
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaag gcaccgaguc ggugcu                                            86


<210>  145
<211>  83
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  145
acacaaauac caguccagcg guuuuagagc uauagcaagu uaaaauaagg cguccguuau       60

caacuuggca ccgagucggu gcu                                               83


<210>  146
<211>  83
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  146
acacaaauac caguccagcg guuuuagagc uauagcaagu uaaaauaagg cguccguuau       60

caacuuggca ccgagucggu gcu                                               83


<210>  147
<211>  83
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conectores internos L1 y L2, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  147
acacaaauac caguccagcg guuuuagagc uauagcaagu uaaaauaagg cuaguccguu       60

aucaauggca ccgagucggu gcu                                               83


<210>  148
<211>  83
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  148
acacaaauac caguccagcg guuuuagagc uauagcaagu uaaaauaagg cuaguccguu       60

aucaauggca ccgagucggu gcu                                               83


<210>  149
<211>  81
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conectores internos L1 y L2, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  149
acacaaauac caguccagcg guuuuagagc uauagcaagu uaaaauaagg cguccguuau       60

caauggcacc gagucggugc u                                                 81


<210>  150
<211>  81
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  150
acacaaauac caguccagcg guuuuagagc uauagcaagu uaaaauaagg cguccguuau       60

caauggcacc gagucggugc u                                                 81


<210>  151
<211>  82
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conectores internos L1 y L2, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  151
acacaaauac caguccagcg guuuuagagc uaguagcaag uuaaaauaag gcguccguua       60

ucaauggcac cgagucggug cu                                                82


<210>  152
<211>  82
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  152
acacaaauac caguccagcg guuuuagagc uaguagcaag uuaaaauaag gcguccguua       60

ucaauggcac cgagucggug cu                                                82


<210>  153
<211>  79
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conectores internos L1 y L2, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  153
acacaaauac caguccagcg guuuuagagc uagcaaguua aaauaaggcg uccguuauca       60

auggcaccga gucggugcu                                                    79


<210>  154
<211>  79
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  154
acacaaauac caguccagcg guuuuagagc uagcaaguua aaauaaggcg uccguuauca       60

auggcaccga gucggugcu                                                    79


<210>  155
<211>  80
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conectores internos L1 y L2, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  155
acacaaauac caguccagcg guuuuagagc ugagcaaguu aaaauaaggc guccguuauc       60

aauggcaccg agucggugcu                                                   80


<210>  156
<211>  80
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  156
acacaaauac caguccagcg guuuuagagc ugagcaaguu aaaauaaggc guccguuauc       60

aauggcaccg agucggugcu                                                   80


<210>  157
<211>  77
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conectores internos L1 y L2, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  157
acacaaauac caguccagcg guuuuagagc gcaaguuaaa auaaggcguc cguuaucaau       60

ggcaccgagu cggugcu                                                      77


<210>  158
<211>  77
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  158
acacaaauac caguccagcg guuuuagagc gcaaguuaaa auaaggcguc cguuaucaau       60

ggcaccgagu cggugcu                                                      77


<210>  159
<211>  87
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L2, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  159
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucacg ggcaccgagu cggugcu                                           87


<210>  160
<211>  87
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  160
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucacg ggcaccgagu cggugcu                                           87


<210>  161
<211>  85
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  161
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucagg caccgagucg gugcu                                             85


<210>  162
<211>  85
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L2, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  162
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucagg caccgagucg gugcu                                             85


<210>  163
<211>  90
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  163
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucacg aaagggcacc gagucggugc                                        90


<210>  164
<211>  90
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  164
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucacg aaagggcacc gagucggugc                                        90


<210>  165
<211>  86
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  165
acacaaauac caguccagcg guuuuagagc uauagcaagu uaaaauaagg cuaguccguu       60

aucacgaaag ggcaccgagu cggugc                                            86


<210>  166
<211>  86
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  166
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucacg ggcaccgagu cggugc                                            86


<210>  167
<211>  80
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  167
acacaaauac caguccagcg guuuuagagc uauagcaagu uaaaauaagg cguccguuau       60

cacgggcacc gagucggugc                                                   80


<210>  168
<211>  82
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  168
acacaaauac caguccagcg guuuuagagc uauagcaagu uaaaauaagg cuaguccguu       60

aucacgggca ccgagucggu gc                                                82


<210>  169
<211>  86
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  169
acacaaauac caguccagcg guuuuagagc uauagcaagu uaaaauaagg cuaguccguu       60

aucacgaaag ggcaccgagu cggugc                                            86


<210>  170
<211>  88
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  170
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaaa auggcaccga gucggugc                                          88


<210>  171
<211>  88
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  171
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaaa auggcaccga gucggugc                                          88


<210>  172
<211>  84
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  172
acacaaauac caguccagcg guuuuagagc uauagcaagu uaaaauaagg cuaguccguu       60

aucaaaaugg caccgagucg gugc                                              84


<210>  173
<211>  86
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  173
acacaaauac caguccagcg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaau ggcaccgagu cggugc                                            86


<210>  174
<211>  82
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  174
acacaaauac caguccagcg guuuuagagc uauagcaagu uaaaauaagg cuaguccguu       60

aucaauggca ccgagucggu gc                                                82


<210>  175
<211>  76
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  175
acacaaauac caguccagcg guuuuagagc gcaaguuaaa auaaggcguc cguuaucaau       60

ggcaccgagu cggugc                                                       76


<210>  176

<400>  176
000

<210>  177
<211>  75
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, sitio dS, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  177
ggcccagacu gagcacguga guuuuagaaa guuaaaauaa ggcuaguccg uuaucacggg       60

caccgagucg gugcu                                                        75


<210>  178
<211>  75
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conectores internos L4 y L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  178
ggcccagacu gagcacguga guuuuagaaa guuaaaauaa ggcuaguccg uuaucacggg       60

caccgagucg gugcu                                                        75


<210>  179
<211>  75
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conectores internos L3 y L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  179
ggcccagacu gagcacguga guuuuagaaa guuaaaauaa ggcuaguccg uuaucacggg       60

caccgagucg gugcu                                                        75


<210>  180
<211>  75
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conectores internos L2 y L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  180
ggcccagacu gagcacguga guuuuagaaa guuaaaauaa ggcuaguccg uuaucacggg       60

caccgagucg gugcu                                                        75


<210>  181
<211>  75
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  181
ggcccagacu gagcacguga guuuuagaaa guuaaaauaa ggcuaguccg uuaucacggg       60

caccgagucg gugcu                                                        75


<210>  182
<211>  79
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  182
ggcccagacu gagcacguga guuuuagagc gcaaguuaaa auaaggcuag uccguuauca       60

cgggcaccga gucggugcu                                                    79


<210>  183
<211>  83
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  183
ggcccagacu gagcacguga guuuuagagc uauagcaagu uaaaauaagg cuaguccguu       60

aucacgggca ccgagucggu gcu                                               83


<210>  184
<211>  83
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<400>  184
ggcccagacu gagcacguga guuuuagagc uauagcaagu uaaaauaagg cuaguccguu       60

aucacgggca ccgagucggu gcu                                               83


<210>  185

<400>  185
000

<210>  186

<400>  186
000

<210>  187

<400>  187
000

<210>  188

<400>  188
000

<210>  189

<400>  189
000

<210>  190

<400>  190
000

<210>  191

<400>  191
000

<210>  192

<400>  192
000

<210>  193

<400>  193
000

<210>  194

<400>  194
000

<210>  195

<400>  195
000

<210>  196

<400>  196
000

<210>  197

<400>  197
000

<210>  198

<400>  198
000

<210>  199

<400>  199
000

<210>  200
<211>  100
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n es a, c, g o u

<400>  200
nnnnnnnnnn nnnnnnnnnn guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  201
<211>  90
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n es a, c, g o u

<400>  201
nnnnnnnnnn nnnnnnnnnn guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucacg aaagggcacc gagucggugc                                        90


<210>  202
<211>  100
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n es a, c, g o u

<400>  202
nnnnnnnnnn nnnnnnnnnn guuuuaguac ucuggaaaca gaaucuacua aaacaaggca       60

aaaugccgug uuuaucucgu caacuuguug gcgagauuuu                            100


<210>  203
<211>  113
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n es a, c, g o u

<400>  203
nnnnnnnnnn nnnnnnnnnn acugggguuc aggaaacuga accucaguaa gcauuggcuc       60

guuuccaaug uugauugcuc cgccggugcu ccuuauuuuu aagggcgccg gca             113


<210>  204
<211>  117
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n es a, c, g o u

<400>  204
nnnnnnnnnn nnnnnnnnnn guuuuuguac ucucaagauu caauaaucuu gcagaagcua       60

caaagauaag gcuucaugcc gaaaucaaca cccugucauu uuauggcagg guguuuu         117


<210>  205
<211>  97
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n es a, c, g o u

<400>  205
nnnnnnnnnn nnnnnnnnnn guuuuuguac ucgaaagaag cuacaaagau aaggcuucau       60

gccgaaauca acacccuguc auuuuauggc agggugu                                97


<210>  206
<211>  94
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n es a, c, g o u

<400>  206
nnnnnnnnnn nnnnnnnnnn gcuggggagc cugaaaaggc uaccuagcaa gaccccuucg       60

uggggucgca uucuucaccc ccagcagggg guuc                                   94


<210>  207
<211>  93
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n es a, c, g o u

<400>  207
nnnnnnnnnn nnnnnnnnnn guuuuagucc cugaaaaggg acuaaaauaa agaguuugcg       60

ggacucugcg ggguuacaau ccccuaaaac cgc                                    93


<210>  208
<211>  94
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  n es a, c, g o u

<400>  208
nnnnnnnnnn nnnnnnnnnn nguuucaguu gcgccgaaag gcgcucugua aucauuaaaa       60

aguauuuuga acggaccucu guuugacacg ucug                                   94


<210>  209
<211>  45
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<222>  (21)..(45)
<223>  n es a, c, g o u

<400>  209
uaauuucuac ucuuguagau nnnnnnnnnn nnnnnnnnnn nnnnn                       45


<210>  210
<211>  55
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<222>  (29)..(55)
<223>  n es a, c, g o u

<400>  210
cuggugcaaa uuugcacuag cuuaaaacnn nnnnnnnnnn nnnnnnnnnn nnnnn            55


<210>  211
<211>  90
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conectores internos L1 y L2; vea en la memoria descriptiva presentada la descripción detallada de sustituciones y modalidades preferidas

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n es a, c, g o u

<400>  211
nnnnnnnnnn nnnnnnnnnn guuuuagagc uauagcaagu uaaaauaagg cguccguuau       60

caacuuaagu ggcaccgagu cggugcuuuu                                        90


<210>  212
<211>  80
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conectores internos L1 y L2; vea en la memoria descriptiva presentada la descripción detallada de sustituciones y modalidades preferidas

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n es a, c, g o u

<400>  212
nnnnnnnnnn nnnnnnnnnn guuuuagagc uauagcaagu uaaaauaagg cguccguuau       60

cacgggcacc gagucggugc                                                   80


<210>  213
<211>  80
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conectores internos L1 y L2, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n es a, c, g o u

<400>  213
nnnnnnnnnn nnnnnnnnnn guuuuagagc uauagcaagu uaaaauaagg cguccguuau       60

cacgggcacc gagucggugc                                                   80


<210>  214
<211>  78
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conectores internos L1 y L2, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n es a, c, g o u

<400>  214
nnnnnnnnnn nnnnnnnnnn guuuuagagc uauagcaagu uaaaauaagg cguccguuau       60

caggcaccga gucggugc                                                     78


<210>  215
<211>  78
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conectores internos L1 y L2, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n es a, c, g o u

<400>  215
nnnnnnnnnn nnnnnnnnnn guuuuagagc uagcaaguua aaauaaggcg uccguuauca       60

cgggcaccga gucggugc                                                     78


<210>  216
<211>  76
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conectores internos L1 y L2, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n es a, c, g o u

<400>  216
nnnnnnnnnn nnnnnnnnnn guuuuagagc uagcaaguua aaauaaggcg uccguuauca       60

ggcaccgagu cggugc                                                       76


<210>  217
<211>  76
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conectores internos L1 y L2, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n es a, c, g o u

<400>  217
nnnnnnnnnn nnnnnnnnnn guuuuagagc uagcaaguua aaauaaggcg uccguuauca       60

ggcaccgagu cggugc                                                       76


<210>  218
<211>  76
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conectores internos L1 y L2, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n es a, c, g o u

<400>  218
nnnnnnnnnn nnnnnnnnnn guuuuagagc uagcaaguua aaauaaggcg uccguuauca       60

ggcaccgagu cggugc                                                       76


<210>  219
<211>  80
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conectores internos L1 y L2, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n es a, c, g o u

<400>  219
nnnnnnnnnn nnnnnnnnnn guuuuagagc uauagcaagu uaaaauaagg cguccguuau       60

cacgggcacc gagucggugc                                                   80


<210>  220
<211>  78
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conectores internos L1 y L2, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n es a, c, g o u

<400>  220
nnnnnnnnnn nnnnnnnnnn guuuuagagc uauagcaagu uaaaauaagg cguccguuau       60

caggcaccga gucggugc                                                     78


<210>  221
<211>  78
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conectores internos L1 y L2, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n es a, c, g o u

<400>  221
nnnnnnnnnn nnnnnnnnnn guuuuagagc uagcaaguua aaauaaggcg uccguuauca       60

cgggcaccga gucggugc                                                     78


<210>  222
<211>  76
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conectores internos L1 y L2, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n es a, c, g o u

<400>  222
nnnnnnnnnn nnnnnnnnnn guuuuagagc uagcaaguua aaauaaggcg uccguuauca       60

ggcaccgagu cggugc                                                       76


<210>  223
<211>  75
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, sitio dS, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n es a, c, g o u

<400>  223
nnnnnnnnnn nnnnnnnnnn guuuuagaaa guuaaaauaa ggcuaguccg uuaucacggg       60

caccgagucg gugcu                                                        75


<210>  224
<211>  75
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conectores internos L1 y L4, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n es a, c, g o u

<400>  224
nnnnnnnnnn nnnnnnnnnn guuuuagaaa guuaaaauaa ggcuaguccg uuaucacggg       60

caccgagucg gugcu                                                        75


<210>  225
<211>  75
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conectores internos L1 y L3, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n es a, c, g o u

<400>  225
nnnnnnnnnn nnnnnnnnnn guuuuagaaa guuaaaauaa ggcuaguccg uuaucacggg       60

caccgagucg gugcu                                                        75


<210>  226
<211>  75
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conectores internos L1 y L2, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n es a, c, g o u

<400>  226
nnnnnnnnnn nnnnnnnnnn guuuuagaaa guuaaaauaa ggcuaguccg uuaucacggg       60

caccgagucg gugcu                                                        75


<210>  227
<211>  75
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n es a, c, g o u

<400>  227
nnnnnnnnnn nnnnnnnnnn guuuuagaaa guuaaaauaa ggcuaguccg uuaucacggg       60

caccgagucg gugcu                                                        75


<210>  228
<211>  79
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n es a, c, g o u

<400>  228
nnnnnnnnnn nnnnnnnnnn guuuuagagc gcaaguuaaa auaaggcuag uccguuauca       60

cgggcaccga gucggugcu                                                    79


<210>  229
<211>  83
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n es a, c, g o u

<400>  229
nnnnnnnnnn nnnnnnnnnn guuuuagagc uauagcaagu uaaaauaagg cuaguccguu       60

aucacgggca ccgagucggu gcu                                               83


<210>  230
<211>  83
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n es a, c, g o u

<400>  230
nnnnnnnnnn nnnnnnnnnn guuuuagagc uauagcaagu uaaaauaagg cuaguccguu       60

aucacgggca ccgagucggu gcu                                               83


<210>  231

<400>  231
000

<210>  232

<400>  232
000

<210>  233

<400>  233
000

<210>  234

<400>  234
000

<210>  235

<400>  235
000

<210>  236

<400>  236
000

<210>  237

<400>  237
000

<210>  238

<400>  238
000

<210>  239

<400>  239
000

<210>  240

<400>  240
000

<210>  241

<400>  241
000

<210>  242

<400>  242
000

<210>  243

<400>  243
000

<210>  244

<400>  244
000

<210>  245

<400>  245
000

<210>  246

<400>  246
000

<210>  247

<400>  247
000

<210>  248

<400>  248
000

<210>  249

<400>  249
000

<210>  250

<400>  250
000

<210>  251

<400>  251
000

<210>  252

<400>  252
000

<210>  253

<400>  253
000

<210>  254

<400>  254
000

<210>  255

<400>  255
000

<210>  256

<400>  256
000

<210>  257

<400>  257
000

<210>  258

<400>  258
000

<210>  259

<400>  259
000

<210>  260

<400>  260
000

<210>  261

<400>  261
000

<210>  262

<400>  262
000

<210>  263

<400>  263
000

<210>  264

<400>  264
000

<210>  265

<400>  265
000

<210>  266

<400>  266
000

<210>  267

<400>  267
000

<210>  268

<400>  268
000

<210>  269

<400>  269
000

<210>  270

<400>  270
000

<210>  271

<400>  271
000

<210>  272

<400>  272
000

<210>  273

<400>  273
000

<210>  274

<400>  274
000

<210>  275

<400>  275
000

<210>  276

<400>  276
000

<210>  277

<400>  277
000

<210>  278

<400>  278
000

<210>  279

<400>  279
000

<210>  280

<400>  280
000

<210>  281

<400>  281
000

<210>  282

<400>  282
000

<210>  283

<400>  283
000

<210>  284

<400>  284
000

<210>  285

<400>  285
000

<210>  286

<400>  286
000

<210>  287

<400>  287
000

<210>  288

<400>  288
000

<210>  289

<400>  289
000

<210>  290

<400>  290
000

<210>  291

<400>  291
000

<210>  292

<400>  292
000

<210>  293

<400>  293
000

<210>  294

<400>  294
000

<210>  295

<400>  295
000

<210>  296

<400>  296
000

<210>  297

<400>  297
000

<210>  298

<400>  298
000

<210>  299

<400>  299
000

<210>  300

<400>  300
000

<210>  301
<211>  1379
<212>  PRT
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  301

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


Gly Gly  Gly Ser Pro Lys Lys  Lys Arg Lys Val 
    1370                 1375                 


<210>  302
<211>  1074
<212>  PRT
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  302

Met Ala Leu Glu Ala Pro Lys Lys Lys Arg Lys Val Gly Ser Asp Tyr 
1               5                   10                  15      


Lys Asp Asp Asp Asp Lys Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile 
            20                  25                  30          


Gly Ile Thr Ser Val Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp 
        35                  40                  45              


Val Ile Asp Ala Gly Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn 
    50                  55                  60                  


Asn Glu Gly Arg Arg Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg 
65                  70                  75                  80  


Arg Arg His Arg Ile Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn 
                85                  90                  95      


Leu Leu Thr Asp His Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala 
            100                 105                 110         


Arg Val Lys Gly Leu Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala 
        115                 120                 125             


Ala Leu Leu His Leu Ala Lys Arg Arg Gly Val His Asn Val Asn Glu 
    130                 135                 140                 


Val Glu Glu Asp Thr Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser 
145                 150                 155                 160 


Arg Asn Ser Lys Ala Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu 
                165                 170                 175     


Glu Arg Leu Lys Lys Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe 
            180                 185                 190         


Lys Thr Ser Asp Tyr Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln 
        195                 200                 205             


Lys Ala Tyr His Gln Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp 
    210                 215                 220                 


Leu Leu Glu Thr Arg Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser 
225                 230                 235                 240 


Pro Phe Gly Trp Lys Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly 
                245                 250                 255     


His Cys Thr Tyr Phe Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr 
            260                 265                 270         


Asn Ala Asp Leu Tyr Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile 
        275                 280                 285             


Thr Arg Asp Glu Asn Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile 
    290                 295                 300                 


Ile Glu Asn Val Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile 
305                 310                 315                 320 


Ala Lys Glu Ile Leu Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val 
                325                 330                 335     


Thr Ser Thr Gly Lys Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp 
            340                 345                 350         


Ile Lys Asp Ile Thr Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu 
        355                 360                 365             


Leu Asp Gln Ile Ala Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp 
    370                 375                 380                 


Ile Gln Glu Glu Leu Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu 
385                 390                 395                 400 


Ile Glu Gln Ile Ser Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu 
                405                 410                 415     


Ser Leu Lys Ala Ile Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn 
            420                 425                 430         


Asp Asn Gln Ile Ala Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys 
        435                 440                 445             


Val Asp Leu Ser Gln Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp 
    450                 455                 460                 


Phe Ile Leu Ser Pro Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys 
465                 470                 475                 480 


Val Ile Asn Ala Ile Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile 
                485                 490                 495     


Ile Glu Leu Ala Arg Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile 
            500                 505                 510         


Asn Glu Met Gln Lys Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu 
        515                 520                 525             


Ile Ile Arg Thr Thr Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys 
    530                 535                 540                 


Ile Lys Leu His Asp Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu 
545                 550                 555                 560 


Ala Ile Pro Leu Glu Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val 
                565                 570                 575     


Asp His Ile Ile Pro Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn 
            580                 585                 590         


Lys Val Leu Val Lys Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr 
        595                 600                 605             


Pro Phe Gln Tyr Leu Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr 
    610                 615                 620                 


Phe Lys Lys His Ile Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser 
625                 630                 635                 640 


Lys Thr Lys Lys Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe 
                645                 650                 655     


Ser Val Gln Lys Asp Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr 
            660                 665                 670         


Ala Thr Arg Gly Leu Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn 
        675                 680                 685             


Asn Leu Asp Val Lys Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe 
    690                 695                 700                 


Leu Arg Arg Lys Trp Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys 
705                 710                 715                 720 


His His Ala Glu Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe 
                725                 730                 735     


Lys Glu Trp Lys Lys Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln 
            740                 745                 750         


Met Phe Glu Glu Lys Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu 
        755                 760                 765             


Gln Glu Tyr Lys Glu Ile Phe Ile Thr Pro His Gln Ile Lys His Ile 
    770                 775                 780                 


Lys Asp Phe Lys Asp Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro 
785                 790                 795                 800 


Asn Arg Glu Leu Ile Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp 
                805                 810                 815     


Lys Gly Asn Thr Leu Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys 
            820                 825                 830         


Asp Asn Asp Lys Leu Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu 
        835                 840                 845             


Leu Met Tyr His His Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile 
    850                 855                 860                 


Met Glu Gln Tyr Gly Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu 
865                 870                 875                 880 


Glu Thr Gly Asn Tyr Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro 
                885                 890                 895     


Val Ile Lys Lys Ile Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu 
            900                 905                 910         


Asp Ile Thr Asp Asp Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu 
        915                 920                 925             


Ser Leu Lys Pro Tyr Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr 
    930                 935                 940                 


Lys Phe Val Thr Val Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr 
945                 950                 955                 960 


Tyr Glu Val Asn Ser Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys 
                965                 970                 975     


Ile Ser Asn Gln Ala Glu Phe Ile Ala Ser Phe Tyr Asn Asn Asp Leu 
            980                 985                 990         


Ile Lys Ile Asn Gly Glu Leu Tyr  Arg Val Ile Gly Val  Asn Asn Asp 
        995                 1000                 1005             


Leu Leu  Asn Arg Ile Glu Val  Asn Met Ile Asp Ile  Thr Tyr Arg 
    1010                 1015                 1020             


Glu Tyr  Leu Glu Asn Met Asn  Asp Lys Arg Pro Pro  Arg Ile Ile 
    1025                 1030                 1035             


Lys Thr  Ile Ala Ser Lys Thr  Gln Ser Ile Lys Lys  Tyr Ser Thr 
    1040                 1045                 1050             


Asp Ile  Leu Gly Asn Leu Tyr  Glu Val Lys Ser Lys  Lys His Pro 
    1055                 1060                 1065             


Gln Ile  Ile Lys Lys Gly 
    1070                 


<210>  303
<211>  1091
<212>  PRT
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  303

Met Lys Tyr His Val Gly Ile Asp Val Gly Thr Phe Ser Val Gly Leu 
1               5                   10                  15      


Ala Ala Ile Glu Val Asp Asp Ala Gly Met Pro Ile Lys Thr Leu Ser 
            20                  25                  30          


Leu Val Ser His Ile His Asp Ser Gly Leu Asp Pro Asp Lys Ile Lys 
        35                  40                  45              


Ser Ala Val Thr Arg Leu Ala Ser Ser Gly Ile Ala Arg Arg Thr Arg 
    50                  55                  60                  


Arg Leu Tyr Arg Arg Lys Arg Arg Arg Leu Gln Gln Leu Asp Lys Phe 
65                  70                  75                  80  


Ile Gln Arg Gln Gly Trp Pro Val Ile Glu Leu Glu Asp Tyr Ser Asp 
                85                  90                  95      


Pro Leu Tyr Pro Trp Lys Val Arg Ala Glu Leu Ala Ala Ser Tyr Ile 
            100                 105                 110         


Ala Asp Glu Lys Glu Arg Gly Glu Lys Leu Ser Val Ala Leu Arg His 
        115                 120                 125             


Ile Ala Arg His Arg Gly Trp Arg Asn Pro Tyr Ala Lys Val Ser Ser 
    130                 135                 140                 


Leu Tyr Leu Pro Asp Glu Pro Ser Asp Ala Phe Lys Ala Ile Arg Glu 
145                 150                 155                 160 


Glu Ile Lys Arg Ala Ser Gly Gln Pro Val Pro Glu Thr Ala Thr Val 
                165                 170                 175     


Gly Gln Met Val Thr Leu Cys Glu Leu Gly Thr Leu Lys Leu Arg Gly 
            180                 185                 190         


Glu Gly Gly Val Leu Ser Ala Arg Leu Gln Gln Ser Asp His Ala Arg 
        195                 200                 205             


Glu Ile Gln Glu Ile Cys Arg Met Gln Glu Ile Gly Gln Glu Leu Tyr 
    210                 215                 220                 


Arg Lys Ile Ile Asp Val Val Phe Ala Ala Glu Ser Pro Lys Gly Ser 
225                 230                 235                 240 


Ala Ser Ser Arg Val Gly Lys Asp Pro Leu Gln Pro Gly Lys Asn Arg 
                245                 250                 255     


Ala Leu Lys Ala Ser Asp Ala Phe Gln Arg Tyr Arg Ile Ala Ala Leu 
            260                 265                 270         


Ile Gly Asn Leu Arg Val Arg Val Asp Gly Glu Lys Arg Ile Leu Ser 
        275                 280                 285             


Val Glu Glu Lys Asn Leu Val Phe Asp His Leu Val Asn Leu Ala Pro 
    290                 295                 300                 


Lys Lys Glu Pro Glu Trp Val Thr Ile Ala Glu Ile Leu Gly Ile Asp 
305                 310                 315                 320 


Arg Gly Gln Leu Ile Gly Thr Ala Thr Met Thr Asp Asp Gly Glu Arg 
                325                 330                 335     


Ala Gly Ala Arg Pro Pro Thr His Asp Thr Asn Arg Ser Ile Val Asn 
            340                 345                 350         


Ser Arg Ile Ala Pro Leu Val Asp Trp Trp Lys Thr Ala Ser Ala Leu 
        355                 360                 365             


Glu Gln His Ala Met Val Lys Ala Leu Ser Asn Ala Glu Val Asp Asp 
    370                 375                 380                 


Phe Asp Ser Pro Glu Gly Ala Lys Val Gln Ala Phe Phe Ala Asp Leu 
385                 390                 395                 400 


Asp Asp Asp Val His Ala Lys Leu Asp Ser Leu His Leu Pro Val Gly 
                405                 410                 415     


Arg Ala Ala Tyr Ser Glu Asp Thr Leu Val Arg Leu Thr Arg Arg Met 
            420                 425                 430         


Leu Ala Asp Gly Val Asp Leu Tyr Thr Ala Arg Leu Gln Glu Phe Gly 
        435                 440                 445             


Ile Glu Pro Ser Trp Thr Pro Pro Ala Pro Arg Ile Gly Glu Pro Val 
    450                 455                 460                 


Gly Asn Pro Ala Val Asp Arg Val Leu Lys Thr Val Ser Arg Trp Leu 
465                 470                 475                 480 


Glu Ser Ala Thr Lys Thr Trp Gly Ala Pro Glu Arg Val Ile Ile Glu 
                485                 490                 495     


His Val Arg Glu Gly Phe Val Thr Glu Lys Arg Ala Arg Glu Met Asp 
            500                 505                 510         


Gly Asp Met Arg Arg Arg Ala Ala Arg Asn Ala Lys Leu Phe Gln Glu 
        515                 520                 525             


Met Gln Glu Lys Leu Asn Val Gln Gly Lys Pro Ser Arg Ala Asp Leu 
    530                 535                 540                 


Trp Arg Tyr Gln Ser Val Gln Arg Gln Asn Cys Gln Cys Ala Tyr Cys 
545                 550                 555                 560 


Gly Ser Pro Ile Thr Phe Ser Asn Ser Glu Met Asp His Ile Val Pro 
                565                 570                 575     


Arg Ala Gly Gln Gly Ser Thr Asn Thr Arg Glu Asn Leu Val Ala Val 
            580                 585                 590         


Cys His Arg Cys Asn Gln Ser Lys Gly Asn Thr Pro Phe Ala Ile Trp 
        595                 600                 605             


Ala Lys Asn Thr Ser Ile Glu Gly Val Ser Val Lys Glu Ala Val Glu 
    610                 615                 620                 


Arg Thr Arg His Trp Val Thr Asp Thr Gly Met Arg Ser Thr Asp Phe 
625                 630                 635                 640 


Lys Lys Phe Thr Lys Ala Val Val Glu Arg Phe Gln Arg Ala Thr Met 
                645                 650                 655     


Asp Glu Glu Ile Asp Ala Arg Ser Met Glu Ser Val Ala Trp Met Ala 
            660                 665                 670         


Asn Glu Leu Arg Ser Arg Val Ala Gln His Phe Ala Ser His Gly Thr 
        675                 680                 685             


Thr Val Arg Val Tyr Arg Gly Ser Leu Thr Ala Glu Ala Arg Arg Ala 
    690                 695                 700                 


Ser Gly Ile Ser Gly Lys Leu Glu Phe Leu Asp Gly Val Gly Lys Ser 
705                 710                 715                 720 


Arg Leu Asp Arg Arg His His Ala Ile Asp Ala Ala Val Ile Ala Phe 
                725                 730                 735     


Thr Ser Asp Tyr Val Ala Glu Thr Leu Ala Val Arg Ser Asn Leu Lys 
            740                 745                 750         


Gln Ser Gln Ala His Arg Gln Glu Ala Pro Gln Trp Arg Glu Phe Thr 
        755                 760                 765             


Gly Lys Asp Ala Glu His Arg Ala Ala Trp Arg Val Trp Cys Gln Lys 
    770                 775                 780                 


Met Glu Lys Leu Ser Ala Leu Leu Thr Glu Asp Leu Arg Asp Asp Arg 
785                 790                 795                 800 


Val Val Val Met Ser Asn Val Arg Leu Arg Leu Gly Asn Gly Ser Ala 
                805                 810                 815     


His Glu Glu Thr Ile Gly Lys Leu Ser Lys Val Lys Leu Gly Ser Gln 
            820                 825                 830         


Leu Ser Val Ser Asp Ile Asp Lys Ala Ser Ser Glu Ala Leu Trp Cys 
        835                 840                 845             


Ala Leu Thr Arg Glu Pro Asp Phe Asp Pro Lys Asp Gly Leu Pro Ala 
    850                 855                 860                 


Asn Pro Glu Arg His Ile Arg Val Asn Gly Thr His Val Tyr Ala Gly 
865                 870                 875                 880 


Asp Asn Ile Gly Leu Phe Pro Val Ser Ala Gly Ser Ile Ala Leu Arg 
                885                 890                 895     


Gly Gly Tyr Ala Glu Leu Gly Ser Ser Phe His His Ala Arg Val Tyr 
            900                 905                 910         


Lys Ile Thr Ser Gly Lys Lys Pro Ala Phe Ala Met Leu Arg Val Tyr 
        915                 920                 925             


Thr Ile Asp Leu Leu Pro Tyr Arg Asn Gln Asp Leu Phe Ser Val Glu 
    930                 935                 940                 


Leu Lys Pro Gln Thr Met Ser Met Arg Gln Ala Glu Lys Lys Leu Arg 
945                 950                 955                 960 


Asp Ala Leu Ala Thr Gly Asn Ala Glu Tyr Leu Gly Trp Leu Val Val 
                965                 970                 975     


Asp Asp Glu Leu Val Val Asp Thr Ser Lys Ile Ala Thr Asp Gln Val 
            980                 985                 990         


Lys Ala Val Glu Ala Glu Leu Gly  Thr Ile Arg Arg Trp  Arg Val Asp 
        995                 1000                 1005             


Gly Phe  Phe Gly Asp Thr Arg  Leu Arg Leu Arg Pro  Leu Gln Met 
    1010                 1015                 1020             


Ser Lys  Glu Gly Ile Lys Lys  Glu Ser Ala Pro Glu  Leu Ser Lys 
    1025                 1030                 1035             


Ile Ile  Asp Arg Pro Gly Trp  Leu Pro Ala Val Asn  Lys Leu Phe 
    1040                 1045                 1050             


Ser Glu  Gly Asn Val Thr Val  Val Arg Arg Asp Ser  Leu Gly Arg 
    1055                 1060                 1065             


Val Arg  Leu Glu Ser Thr Ala  His Leu Pro Val Thr  Trp Lys Val 
    1070                 1075                 1080             


Gln Pro  Lys Lys Lys Arg Lys  Val 
    1085                 1090     


<210>  304
<211>  1121
<212>  PRT
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  304

Met Ser Asp Leu Val Leu Gly Leu Asp Ile Gly Ile Gly Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Asn Lys Val Thr Gly Glu Ile Ile His Lys Asn Ser 
            20                  25                  30          


Arg Ile Phe Pro Ala Ala Gln Ala Glu Asn Asn Leu Val Arg Arg Thr 
        35                  40                  45              


Asn Arg Gln Gly Arg Arg Leu Thr Arg Arg Lys Lys His Arg Ile Val 
    50                  55                  60                  


Arg Leu Asn Arg Leu Phe Glu Glu Ser Gly Leu Ile Thr Asp Phe Thr 
65                  70                  75                  80  


Lys Ile Ser Ile Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly Leu 
                85                  90                  95      


Thr Asp Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Met 
            100                 105                 110         


Val Lys His Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Asp Asp Gly 
        115                 120                 125             


Asn Ser Ser Val Gly Asp Tyr Ala Gln Ile Val Lys Glu Asn Ser Lys 
    130                 135                 140                 


Gln Leu Glu Thr Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Tyr Gln 
145                 150                 155                 160 


Thr Tyr Gly Gln Leu Arg Gly Asp Phe Thr Val Glu Lys Asp Gly Lys 
                165                 170                 175     


Lys His Arg Leu Ile Asn Val Phe Pro Thr Ser Ala Tyr Arg Ser Glu 
            180                 185                 190         


Ala Leu Arg Ile Leu Gln Thr Gln Gln Glu Phe Asn Pro Gln Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Asn Arg Tyr Leu Glu Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Tyr Arg Thr Ser Gly Glu Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Pro Asp Glu Phe Arg Ala Ala Lys Ala Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Lys Glu Gln Lys Asn Gln Ile 
    290                 295                 300                 


Ile Asn Tyr Val Lys Asn Glu Lys Ala Met Gly Pro Ala Lys Leu Phe 
305                 310                 315                 320 


Lys Tyr Ile Ala Lys Leu Leu Ser Cys Asp Val Ala Asp Ile Lys Glu 
                325                 330                 335     


Tyr Arg Ile Asp Lys Ser Gly Lys Ala Glu Ile His Thr Phe Glu Ala 
            340                 345                 350         


Tyr Arg Lys Met Lys Thr Leu Glu Thr Leu Asp Ile Glu Gln Met Asp 
        355                 360                 365             


Arg Glu Thr Leu Asp Lys Leu Ala Tyr Val Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Gln Glu Ala Leu Glu His Glu Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Phe Ser Gln Lys Gln Val Asp Glu Leu Val Gln Phe Arg Lys Ala Asn 
                405                 410                 415     


Ser Ser Ile Phe Gly Lys Gly Trp His Asn Phe Ser Val Lys Leu Met 
            420                 425                 430         


Met Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr 
        435                 440                 445             


Ile Leu Thr Arg Leu Gly Lys Gln Lys Thr Thr Ser Ser Ser Asn Lys 
    450                 455                 460                 


Thr Lys Tyr Ile Asp Glu Lys Leu Leu Thr Glu Glu Ile Tyr Asn Pro 
465                 470                 475                 480 


Val Val Ala Lys Ser Val Arg Gln Ala Ile Lys Ile Val Asn Ala Ala 
                485                 490                 495     


Ile Lys Glu Tyr Gly Asp Phe Asp Asn Ile Val Ile Glu Met Ala Arg 
            500                 505                 510         


Glu Thr Asn Glu Asp Asp Glu Lys Lys Ala Ile Gln Lys Ile Gln Lys 
        515                 520                 525             


Ala Asn Lys Asp Glu Lys Asp Ala Ala Met Leu Lys Ala Ala Asn Gln 
    530                 535                 540                 


Tyr Asn Gly Lys Ala Glu Leu Pro His Ser Val Phe His Gly His Lys 
545                 550                 555                 560 


Gln Leu Ala Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Arg Cys 
                565                 570                 575     


Leu Tyr Thr Gly Lys Thr Ile Ser Ile His Asp Leu Ile Asn Asn Ser 
            580                 585                 590         


Asn Gln Phe Glu Val Asp His Ile Leu Pro Leu Ser Ile Thr Phe Asp 
        595                 600                 605             


Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ala Thr Ala Asn Gln Glu 
    610                 615                 620                 


Lys Gly Gln Arg Thr Pro Tyr Gln Ala Leu Asp Ser Met Asp Asp Ala 
625                 630                 635                 640 


Trp Ser Phe Arg Glu Leu Lys Ala Phe Val Arg Glu Ser Lys Thr Leu 
                645                 650                 655     


Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys 
            660                 665                 670         


Phe Asp Val Arg Lys Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 
        675                 680                 685             


Tyr Ala Ser Arg Val Val Leu Asn Ala Leu Gln Glu His Phe Arg Ala 
    690                 695                 700                 


His Lys Ile Asp Thr Lys Val Ser Val Val Arg Gly Gln Phe Thr Ser 
705                 710                 715                 720 


Gln Leu Arg Arg His Trp Gly Ile Glu Lys Thr Arg Asp Thr Tyr His 
                725                 730                 735     


His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ile Gln Leu Asn 
            740                 745                 750         


Leu Trp Lys Lys Gln Lys Asn Thr Leu Val Ser Tyr Ser Glu Asp Gln 
        755                 760                 765             


Leu Leu Asp Ile Glu Thr Gly Glu Leu Ile Ser Asp Asp Glu Tyr Lys 
    770                 775                 780                 


Glu Ser Val Phe Lys Ala Pro Tyr Gln His Phe Val Asp Thr Leu Lys 
785                 790                 795                 800 


Ser Lys Glu Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gln Val Asp Ser 
                805                 810                 815     


Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg Gln 
            820                 825                 830         


Ala Lys Val Gly Lys Asp Lys Ala Asp Glu Thr Tyr Val Leu Gly Lys 
        835                 840                 845             


Ile Lys Asp Ile Tyr Thr Gln Asp Gly Tyr Asp Ala Phe Met Lys Ile 
    850                 855                 860                 


Tyr Lys Lys Asp Lys Ser Lys Phe Leu Met Tyr Arg His Asp Pro Gln 
865                 870                 875                 880 


Thr Phe Glu Lys Val Ile Glu Pro Ile Leu Glu Asn Tyr Pro Asn Lys 
                885                 890                 895     


Gln Ile Asn Glu Lys Gly Lys Glu Val Pro Val Asn Pro Phe Leu Lys 
            900                 905                 910         


Tyr Lys Glu Glu His Gly Tyr Ile Arg Lys Tyr Ser Lys Lys Gly Asn 
        915                 920                 925             


Gly Pro Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Ser Lys Leu Gly Asn 
    930                 935                 940                 


His Ile Asp Ile Thr Pro Lys Asp Ser Asn Asn Lys Val Val Leu Gln 
945                 950                 955                 960 


Ser Val Ser Pro Trp Arg Ala Asp Val Tyr Phe Asn Lys Thr Thr Gly 
                965                 970                 975     


Lys Tyr Glu Ile Leu Gly Leu Lys Tyr Ala Asp Leu Gln Phe Glu Lys 
            980                 985                 990         


Gly Thr Gly Thr Tyr Lys Ile Ser  Gln Glu Lys Tyr Asn  Asp Ile Lys 
        995                 1000                 1005             


Lys Lys  Glu Gly Val Asp Ser  Asp Ser Glu Phe Lys  Phe Thr Leu 
    1010                 1015                 1020             


Tyr Lys  Asn Asp Leu Leu Leu  Val Lys Asp Thr Glu  Thr Lys Glu 
    1025                 1030                 1035             


Gln Gln  Leu Phe Arg Phe Leu  Ser Arg Thr Met Pro  Lys Gln Lys 
    1040                 1045                 1050             


His Tyr  Val Glu Leu Lys Pro  Tyr Asp Lys Gln Lys  Phe Glu Gly 
    1055                 1060                 1065             


Gly Glu  Ala Leu Ile Lys Val  Leu Gly Asn Val Ala  Asn Ser Gly 
    1070                 1075                 1080             


Gln Cys  Lys Lys Gly Leu Gly  Lys Ser Asn Ile Ser  Ile Tyr Lys 
    1085                 1090                 1095             


Val Arg  Thr Asp Val Leu Gly  Asn Gln His Ile Ile  Lys Asn Glu 
    1100                 1105                 1110             


Gly Asp  Lys Pro Lys Leu Asp  Phe 
    1115                 1120     


<210>  305

<400>  305
000

<210>  306
<211>  1155
<212>  PRT
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  306

Met Ser Leu Gln Leu Ile Ile Lys Gly Val Glu Tyr Gly Arg Gly Ala 
1               5                   10                  15      


Asp Pro Thr Met Gly Gly Ser Glu Val Gly Thr Val Pro Val Thr Trp 
            20                  25                  30          


Arg Leu Gly Val Asp Val Gly Glu Arg Ser Ile Gly Leu Ala Ala Val 
        35                  40                  45              


Ser Tyr Glu Glu Asp Lys Pro Lys Glu Ile Leu Ala Ala Val Ser Trp 
    50                  55                  60                  


Ile His Asp Gly Gly Val Gly Asp Glu Arg Ser Gly Ala Ser Arg Leu 
65                  70                  75                  80  


Ala Leu Arg Gly Met Ala Arg Arg Ala Arg Arg Leu Arg Arg Phe Arg 
                85                  90                  95      


Arg Ala Arg Leu Arg Asp Leu Asp Met Leu Leu Ser Glu Leu Gly Trp 
            100                 105                 110         


Thr Pro Leu Pro Asp Lys Asn Val Ser Pro Val Asp Ala Trp Leu Ala 
        115                 120                 125             


Arg Lys Arg Leu Ala Glu Glu Tyr Val Val Asp Glu Thr Glu Arg Arg 
    130                 135                 140                 


Arg Leu Leu Gly Tyr Ala Val Ser His Met Ala Arg His Arg Gly Trp 
145                 150                 155                 160 


Arg Asn Pro Trp Thr Thr Ile Lys Asp Leu Lys Asn Leu Pro Gln Pro 
                165                 170                 175     


Ser Asp Ser Trp Glu Arg Thr Arg Glu Ser Leu Glu Ala Arg Tyr Ser 
            180                 185                 190         


Val Ser Leu Glu Pro Gly Thr Val Gly Gln Trp Ala Gly Tyr Leu Leu 
        195                 200                 205             


Gln Arg Ala Pro Gly Ile Arg Leu Asn Pro Thr Gln Gln Ser Ala Gly 
    210                 215                 220                 


Arg Arg Ala Glu Leu Ser Asn Ala Thr Ala Phe Glu Thr Arg Leu Arg 
225                 230                 235                 240 


Gln Glu Asp Val Leu Trp Glu Leu Arg Cys Ile Ala Asp Val Gln Gly 
                245                 250                 255     


Leu Pro Glu Asp Val Val Ser Asn Val Ile Asp Ala Val Phe Cys Gln 
            260                 265                 270         


Lys Arg Pro Ser Val Pro Ala Glu Arg Ile Gly Arg Asp Pro Leu Asp 
        275                 280                 285             


Pro Ser Gln Leu Arg Ala Ser Arg Ala Cys Leu Glu Phe Gln Glu Tyr 
    290                 295                 300                 


Arg Ile Val Ala Ala Val Ala Asn Leu Arg Ile Arg Asp Gly Ser Gly 
305                 310                 315                 320 


Ser Arg Pro Leu Ser Leu Glu Glu Arg Asn Ala Val Ile Glu Ala Leu 
                325                 330                 335     


Leu Ala Gln Thr Glu Arg Ser Leu Thr Trp Ser Asp Ile Ala Leu Glu 
            340                 345                 350         


Ile Leu Lys Leu Pro Asn Glu Ser Asp Leu Thr Ser Val Pro Glu Glu 
        355                 360                 365             


Asp Gly Pro Ser Ser Leu Ala Tyr Ser Gln Phe Ala Pro Phe Asp Glu 
    370                 375                 380                 


Thr Ser Ala Arg Ile Ala Glu Phe Ile Ala Lys Asn Arg Arg Lys Ile 
385                 390                 395                 400 


Pro Thr Phe Ala Gln Trp Trp Gln Glu Gln Asp Arg Thr Ser Arg Ser 
                405                 410                 415     


Asp Leu Val Ala Ala Asp Asn Ser Ile Ala Gly Glu Glu Glu Gln Glu 
            420                 425                 430         


Leu Leu Val His Leu Pro Asp Ala Glu Leu Glu Ala Leu Glu Gly Leu 
        435                 440                 445             


Ala Leu Pro Ser Gly Arg Val Ala Tyr Ser Arg Leu Thr Leu Ser Gly 
    450                 455                 460                 


Leu Thr Arg Val Met Arg Asp Asp Gly Val Asp Val His Asn Ala Arg 
465                 470                 475                 480 


Lys Thr Cys Phe Gly Val Asp Asp Asn Trp Arg Pro Pro Leu Pro Ala 
                485                 490                 495     


Leu His Glu Ala Thr Gly His Pro Val Val Asp Arg Asn Leu Ala Ile 
            500                 505                 510         


Leu Arg Lys Phe Leu Ser Ser Ala Thr Met Arg Trp Gly Pro Pro Gln 
        515                 520                 525             


Ser Ile Val Val Glu Leu Ala Arg Gly Ala Ser Glu Ser Arg Glu Arg 
    530                 535                 540                 


Gln Ala Glu Glu Glu Ala Ala Arg Arg Ala His Arg Lys Ala Asn Asp 
545                 550                 555                 560 


Arg Ile Arg Ala Glu Leu Arg Ala Ser Gly Leu Ser Asp Pro Ser Pro 
                565                 570                 575     


Ala Asp Leu Val Arg Ala Arg Leu Leu Glu Leu Tyr Asp Cys His Cys 
            580                 585                 590         


Met Tyr Cys Gly Ala Pro Ile Ser Trp Glu Asn Ser Glu Leu Asp His 
        595                 600                 605             


Ile Val Pro Arg Thr Asp Gly Gly Ser Asn Arg His Glu Asn Leu Ala 
    610                 615                 620                 


Ile Thr Cys Gly Ala Cys Asn Lys Glu Lys Gly Arg Arg Pro Phe Ala 
625                 630                 635                 640 


Ser Trp Ala Glu Thr Ser Asn Arg Val Gln Leu Arg Asp Val Ile Asp 
                645                 650                 655     


Arg Val Gln Lys Leu Lys Tyr Ser Gly Asn Met Tyr Trp Thr Arg Asp 
            660                 665                 670         


Glu Phe Ser Arg Tyr Lys Lys Ser Val Val Ala Arg Leu Lys Arg Arg 
        675                 680                 685             


Thr Ser Asp Pro Glu Val Ile Gln Ser Ile Glu Ser Thr Gly Tyr Ala 
    690                 695                 700                 


Ala Val Ala Leu Arg Asp Arg Leu Leu Ser Tyr Gly Glu Lys Asn Gly 
705                 710                 715                 720 


Val Ala Gln Val Ala Val Phe Arg Gly Gly Val Thr Ala Glu Ala Arg 
                725                 730                 735     


Arg Trp Leu Asp Ile Ser Ile Glu Arg Leu Phe Ser Arg Val Ala Ile 
            740                 745                 750         


Phe Ala Gln Ser Thr Ser Thr Lys Arg Leu Asp Arg Arg His His Ala 
        755                 760                 765             


Val Asp Ala Val Val Leu Thr Thr Leu Thr Pro Gly Val Ala Lys Thr 
    770                 775                 780                 


Leu Ala Asp Ala Arg Ser Arg Arg Val Ser Ala Glu Phe Trp Arg Arg 
785                 790                 795                 800 


Pro Ser Asp Val Asn Arg His Ser Thr Glu Glu Pro Gln Ser Pro Ala 
                805                 810                 815     


Tyr Arg Gln Trp Lys Glu Ser Cys Ser Gly Leu Gly Asp Leu Leu Ile 
            820                 825                 830         


Ser Thr Ala Ala Arg Asp Ser Ile Ala Val Ala Ala Pro Leu Arg Leu 
        835                 840                 845             


Arg Pro Thr Gly Ala Leu His Glu Glu Thr Leu Arg Ala Phe Ser Glu 
    850                 855                 860                 


His Thr Val Gly Ala Ala Trp Lys Gly Ala Glu Leu Arg Arg Ile Val 
865                 870                 875                 880 


Glu Pro Glu Val Tyr Ala Ala Phe Leu Ala Leu Thr Asp Pro Gly Gly 
                885                 890                 895     


Arg Phe Leu Lys Val Ser Pro Ser Glu Asp Val Leu Pro Ala Asp Glu 
            900                 905                 910         


Asn Arg His Ile Val Leu Ser Asp Arg Val Leu Gly Pro Arg Asp Arg 
        915                 920                 925             


Val Lys Leu Phe Pro Asp Asp Arg Gly Ser Ile Arg Val Arg Gly Gly 
    930                 935                 940                 


Ala Ala Tyr Ile Ala Ser Phe His His Ala Arg Val Phe Arg Trp Gly 
945                 950                 955                 960 


Ser Ser His Ser Pro Ser Phe Ala Leu Leu Arg Val Ser Leu Ala Asp 
                965                 970                 975     


Leu Ala Val Ala Gly Leu Leu Arg Asp Gly Val Asp Val Phe Thr Ala 
            980                 985                 990         


Glu Leu Pro Pro Trp Thr Pro Ala  Trp Arg Tyr Ala Ser  Ile Ala Leu 
        995                 1000                 1005             


Val Lys  Ala Val Glu Ser Gly  Asp Ala Lys Gln Val  Gly Trp Leu 
    1010                 1015                 1020             


Val Pro  Gly Asp Glu Leu Asp  Phe Gly Pro Glu Gly  Val Thr Thr 
    1025                 1030                 1035             


Ala Ala  Gly Asp Leu Ser Met  Phe Leu Lys Tyr Phe  Pro Glu Arg 
    1040                 1045                 1050             


His Trp  Val Val Thr Gly Phe  Glu Asp Asp Lys Arg  Ile Asn Leu 
    1055                 1060                 1065             


Lys Pro  Ala Phe Leu Ser Ala  Glu Gln Ala Glu Val  Leu Arg Thr 
    1070                 1075                 1080             


Glu Arg  Ser Asp Arg Pro Asp  Thr Leu Thr Glu Ala  Gly Glu Ile 
    1085                 1090                 1095             


Leu Ala  Gln Phe Phe Pro Arg  Cys Trp Arg Ala Thr  Val Ala Lys 
    1100                 1105                 1110             


Val Leu  Cys His Pro Gly Leu  Thr Val Ile Arg Arg  Thr Ala Leu 
    1115                 1120                 1125             


Gly Gln  Pro Arg Trp Arg Arg  Gly His Leu Pro Tyr  Ser Trp Arg 
    1130                 1135                 1140             


Pro Trp  Ser Ala Asp Pro Trp  Ser Gly Gly Thr Pro  
    1145                 1150                 1155 


<210>  307
<211>  984
<212>  PRT
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  307

Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Asp His Ser Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn Tyr Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210>  308
<211>  1629
<212>  PRT
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  308

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Val  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Val Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Thr Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Thr Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Thr Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  309
<211>  1307
<212>  PRT
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  309

Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
            20                  25                  30          


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
        35                  40                  45              


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
    50                  55                  60                  


Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
                85                  90                  95      


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
            100                 105                 110         


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
        115                 120                 125             


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
    130                 135                 140                 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 
                165                 170                 175     


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
            180                 185                 190         


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe 
        195                 200                 205             


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
    210                 215                 220                 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
225                 230                 235                 240 


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
                245                 250                 255     


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
        275                 280                 285             


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
    290                 295                 300                 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
305                 310                 315                 320 


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 
                325                 330                 335     


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
            340                 345                 350         


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
        355                 360                 365             


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr 
    370                 375                 380                 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
385                 390                 395                 400 


Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 
                405                 410                 415     


Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 
            420                 425                 430         


Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 
        435                 440                 445             


Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 
    450                 455                 460                 


Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 
465                 470                 475                 480 


Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 
                485                 490                 495     


Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 
            500                 505                 510         


Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 
        515                 520                 525             


Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp 
    530                 535                 540                 


Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 
545                 550                 555                 560 


Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 
                565                 570                 575     


Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 
            580                 585                 590         


Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys 
        595                 600                 605             


Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 
    610                 615                 620                 


Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 
625                 630                 635                 640 


Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 
                645                 650                 655     


Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 
            660                 665                 670         


Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 
        675                 680                 685             


Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 
    690                 695                 700                 


Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 
705                 710                 715                 720 


Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 
                725                 730                 735     


Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 
            740                 745                 750         


Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 
        755                 760                 765             


Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 
    770                 775                 780                 


Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His 
785                 790                 795                 800 


Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 
                805                 810                 815     


Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 
            820                 825                 830         


Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 
        835                 840                 845             


Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 
    850                 855                 860                 


Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln 
865                 870                 875                 880 


Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 
                885                 890                 895     


Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg 
            900                 905                 910         


Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 
        915                 920                 925             


Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 
    930                 935                 940                 


Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 
945                 950                 955                 960 


Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 
                965                 970                 975     


His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu 
            980                 985                 990         


Glu Asn Leu Asn Phe Gly Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu 
        995                 1000                 1005             


Lys Ala  Val Tyr Gln Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1010                 1015                 1020             


Asn Cys  Leu Val Leu Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly 
    1025                 1030                 1035             


Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala 
    1040                 1045                 1050             


Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro 
    1055                 1060                 1065             


Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe 
    1070                 1075                 1080             


Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe Leu 
    1085                 1090                 1095             


Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
    1100                 1105                 1110             


Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly 
    1115                 1120                 1125             


Leu Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn 
    1130                 1135                 1140             


Glu Thr  Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys 
    1145                 1150                 1155             


Arg Ile  Val Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr 
    1160                 1165                 1170             


Arg Asp  Leu Tyr Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu 
    1175                 1180                 1185             


Lys Gly  Ile Val Phe Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu 
    1190                 1195                 1200             


Leu Glu  Asn Asp Asp Ser His  Ala Ile Asp Thr Met  Val Ala Leu 
    1205                 1210                 1215             


Ile Arg  Ser Val Leu Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly 
    1220                 1225                 1230             


Glu Asp  Tyr Ile Asn Ser Pro  Val Arg Asp Leu Asn  Gly Val Cys 
    1235                 1240                 1245             


Phe Asp  Ser Arg Phe Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp 
    1250                 1255                 1260             


Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu 
    1265                 1270                 1275             


Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile 
    1280                 1285                 1290             


Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn 
    1295                 1300                 1305         


<210>  310
<211>  1082
<212>  PRT
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  310

Met Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Glu 
            20                  25                  30          


Glu Asn Pro Ile Arg Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asn Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Ile Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Ser Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Val Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Val 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Cys Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp His Ile Leu Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Arg Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Lys Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Ala His Lys Asp Thr Leu Arg Ser 
        835                 840                 845             


Ala Lys Arg Phe Val Lys His Asn Glu Lys Ile Ser Val Lys Arg Val 
    850                 855                 860                 


Trp Leu Thr Glu Ile Lys Leu Ala Asp Leu Glu Asn Met Val Asn Tyr 
865                 870                 875                 880 


Lys Asn Gly Arg Glu Ile Glu Leu Tyr Glu Ala Leu Lys Ala Arg Leu 
                885                 890                 895     


Glu Ala Tyr Gly Gly Asn Ala Lys Gln Ala Phe Asp Pro Lys Asp Asn 
            900                 905                 910         


Pro Phe Tyr Lys Lys Gly Gly Gln Leu Val Lys Ala Val Arg Val Glu 
        915                 920                 925             


Lys Thr Gln Glu Ser Gly Val Leu Leu Asn Lys Lys Asn Ala Tyr Thr 
    930                 935                 940                 


Ile Ala Asp Asn Gly Asp Met Val Arg Val Asp Val Phe Cys Lys Val 
945                 950                 955                 960 


Asp Lys Lys Gly Lys Asn Gln Tyr Phe Ile Val Pro Ile Tyr Ala Trp 
                965                 970                 975     


Gln Val Ala Glu Asn Ile Leu Pro Asp Ile Asp Cys Lys Gly Tyr Arg 
            980                 985                 990         


Ile Asp Asp Ser Tyr Thr Phe Cys  Phe Ser Leu His Lys  Tyr Asp Leu 
        995                 1000                 1005             


Ile Ala  Phe Gln Lys Asp Glu  Lys Ser Lys Val Glu  Phe Ala Tyr 
    1010                 1015                 1020             


Tyr Ile  Asn Cys Asp Ser Ser  Asn Gly Arg Phe Tyr  Leu Ala Trp 
    1025                 1030                 1035             


His Asp  Lys Gly Ser Lys Glu  Gln Gln Phe Arg Ile  Ser Thr Gln 
    1040                 1045                 1050             


Asn Leu  Val Leu Ile Gln Lys  Tyr Gln Val Asn Glu  Leu Gly Lys 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg 
    1070                 1075                 1080         


<210>  311
<211>  1173
<212>  PRT
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  311

Met Arg Pro Ile Glu Pro Trp Ile Leu Gly Leu Asp Ile Gly Thr Asp 
1               5                   10                  15      


Ser Leu Gly Trp Ala Val Phe Ser Cys Glu Glu Lys Gly Pro Pro Thr 
            20                  25                  30          


Ala Lys Glu Leu Leu Gly Gly Gly Val Arg Leu Phe Asp Ser Gly Arg 
        35                  40                  45              


Asp Ala Lys Asp His Thr Ser Arg Gln Ala Glu Arg Gly Ala Phe Arg 
    50                  55                  60                  


Arg Ala Arg Arg Gln Thr Arg Thr Trp Pro Trp Arg Arg Asp Arg Leu 
65                  70                  75                  80  


Ile Ala Leu Phe Gln Ala Ala Gly Leu Thr Pro Pro Ala Ala Glu Thr 
                85                  90                  95      


Arg Gln Ile Ala Leu Ala Leu Arg Arg Glu Ala Val Ser Arg Pro Leu 
            100                 105                 110         


Ala Pro Asp Ala Leu Trp Ala Ala Leu Leu His Leu Ala His His Arg 
        115                 120                 125             


Gly Phe Arg Ser Asn Arg Ile Asp Lys Arg Glu Arg Ala Ala Ala Lys 
    130                 135                 140                 


Ala Leu Ala Lys Ala Lys Pro Ala Lys Ala Thr Ala Lys Ala Thr Ala 
145                 150                 155                 160 


Pro Ala Lys Glu Ala Asp Asp Glu Ala Gly Phe Trp Glu Gly Ala Glu 
                165                 170                 175     


Ala Ala Leu Arg Gln Arg Met Ala Ala Ser Gly Ala Pro Thr Val Gly 
            180                 185                 190         


Ala Leu Leu Ala Asp Asp Leu Asp Arg Gly Gln Pro Val Arg Met Arg 
        195                 200                 205             


Tyr Asn Gln Ser Asp Arg Asp Gly Val Val Ala Pro Thr Arg Ala Leu 
    210                 215                 220                 


Ile Ala Glu Glu Leu Ala Glu Ile Val Ala Arg Gln Ser Ser Ala Tyr 
225                 230                 235                 240 


Pro Gly Leu Asp Trp Pro Ala Val Thr Arg Leu Val Leu Asp Gln Arg 
                245                 250                 255     


Pro Leu Arg Ser Lys Gly Ala Gly Pro Cys Ala Phe Leu Pro Gly Glu 
            260                 265                 270         


Asp Arg Ala Leu Arg Ala Leu Pro Thr Val Gln Asp Phe Ile Ile Arg 
        275                 280                 285             


Gln Thr Leu Ala Asn Leu Arg Leu Pro Ser Thr Ser Ala Asp Glu Pro 
    290                 295                 300                 


Arg Pro Leu Thr Asp Glu Glu His Ala Lys Ala Leu Ala Leu Leu Ser 
305                 310                 315                 320 


Thr Ala Arg Phe Val Glu Trp Pro Ala Leu Arg Arg Ala Leu Gly Leu 
                325                 330                 335     


Lys Arg Gly Val Lys Phe Thr Ala Glu Thr Glu Arg Asn Gly Ala Lys 
            340                 345                 350         


Gln Ala Ala Arg Gly Thr Ala Gly Asn Leu Thr Glu Ala Ile Leu Ala 
        355                 360                 365             


Pro Leu Ile Pro Gly Trp Ser Gly Trp Asp Leu Asp Arg Lys Asp Arg 
    370                 375                 380                 


Val Phe Ser Asp Leu Trp Ala Ala Arg Gln Asp Arg Ser Ala Leu Leu 
385                 390                 395                 400 


Ala Leu Ile Gly Asp Pro Arg Gly Pro Thr Arg Val Thr Glu Asp Glu 
                405                 410                 415     


Thr Ala Glu Ala Val Ala Asp Ala Ile Gln Ile Val Leu Pro Thr Gly 
            420                 425                 430         


Arg Ala Ser Leu Ser Ala Lys Ala Ala Arg Ala Ile Ala Gln Ala Met 
        435                 440                 445             


Ala Pro Gly Ile Gly Tyr Asp Glu Ala Val Thr Leu Ala Leu Gly Leu 
    450                 455                 460                 


His His Ser His Arg Pro Arg Gln Glu Arg Leu Ala Arg Leu Pro Tyr 
465                 470                 475                 480 


Tyr Ala Ala Ala Leu Pro Asp Val Gly Leu Asp Gly Asp Pro Val Gly 
                485                 490                 495     


Pro Pro Pro Ala Glu Asp Asp Gly Ala Ala Ala Glu Ala Tyr Tyr Gly 
            500                 505                 510         


Arg Ile Gly Asn Ile Ser Val His Ile Ala Leu Asn Glu Thr Arg Lys 
        515                 520                 525             


Ile Val Asn Ala Leu Leu His Arg His Gly Pro Ile Leu Arg Leu Val 
    530                 535                 540                 


Met Val Glu Thr Thr Arg Glu Leu Lys Ala Gly Ala Asp Glu Arg Lys 
545                 550                 555                 560 


Arg Met Ile Ala Glu Gln Ala Glu Arg Glu Arg Glu Asn Ala Glu Ile 
                565                 570                 575     


Asp Val Glu Leu Arg Lys Ser Asp Arg Trp Met Ala Asn Ala Arg Glu 
            580                 585                 590         


Arg Arg Gln Arg Val Arg Leu Ala Arg Arg Gln Asn Asn Leu Cys Pro 
        595                 600                 605             


Tyr Thr Ser Thr Pro Ile Gly His Ala Asp Leu Leu Gly Asp Ala Tyr 
    610                 615                 620                 


Asp Ile Asp His Val Ile Pro Leu Ala Arg Gly Gly Arg Asp Ser Leu 
625                 630                 635                 640 


Asp Asn Met Val Leu Cys Gln Ser Asp Ala Asn Lys Thr Lys Gly Asp 
                645                 650                 655     


Lys Thr Pro Trp Glu Ala Phe His Asp Lys Pro Gly Trp Ile Ala Gln 
            660                 665                 670         


Arg Asp Asp Phe Leu Ala Arg Leu Asp Pro Gln Thr Ala Lys Ala Leu 
        675                 680                 685             


Ala Trp Arg Phe Ala Asp Asp Ala Gly Glu Arg Val Ala Arg Lys Ser 
    690                 695                 700                 


Ala Glu Asp Glu Asp Gln Gly Phe Leu Pro Arg Gln Leu Thr Asp Thr 
705                 710                 715                 720 


Gly Tyr Ile Ala Arg Val Ala Leu Arg Tyr Leu Ser Leu Val Thr Asn 
                725                 730                 735     


Glu Pro Asn Ala Val Val Ala Thr Asn Gly Arg Leu Thr Gly Leu Leu 
            740                 745                 750         


Arg Leu Ala Trp Asp Ile Thr Pro Gly Pro Ala Pro Arg Asp Leu Leu 
        755                 760                 765             


Pro Thr Pro Arg Asp Ala Leu Arg Asp Asp Thr Ala Ala Arg Arg Phe 
    770                 775                 780                 


Leu Asp Gly Leu Thr Pro Pro Pro Leu Ala Lys Ala Val Glu Gly Ala 
785                 790                 795                 800 


Val Gln Ala Arg Leu Ala Ala Leu Gly Arg Ser Arg Val Ala Asp Ala 
                805                 810                 815     


Gly Leu Ala Asp Ala Leu Gly Leu Thr Leu Ala Ser Leu Gly Gly Gly 
            820                 825                 830         


Gly Lys Asn Arg Ala Asp His Arg His His Phe Ile Asp Ala Ala Met 
        835                 840                 845             


Ile Ala Val Thr Thr Arg Gly Leu Ile Asn Gln Ile Asn Gln Ala Ser 
    850                 855                 860                 


Gly Ala Gly Arg Ile Leu Asp Leu Arg Lys Trp Pro Arg Thr Asn Phe 
865                 870                 875                 880 


Glu Pro Pro Tyr Pro Thr Phe Arg Ala Glu Val Met Lys Gln Trp Asp 
                885                 890                 895     


His Ile His Pro Ser Ile Arg Pro Ala His Arg Asp Gly Gly Ser Leu 
            900                 905                 910         


His Ala Ala Thr Val Phe Gly Val Arg Asn Arg Pro Asp Ala Arg Val 
        915                 920                 925             


Leu Val Gln Arg Lys Pro Val Glu Lys Leu Phe Leu Asp Ala Asn Ala 
    930                 935                 940                 


Lys Pro Leu Pro Ala Asp Lys Ile Ala Glu Ile Ile Asp Gly Phe Ala 
945                 950                 955                 960 


Ser Pro Arg Met Ala Lys Arg Phe Lys Ala Leu Leu Ala Arg Tyr Gln 
                965                 970                 975     


Ala Ala His Pro Glu Val Pro Pro Ala Leu Ala Ala Leu Ala Val Ala 
            980                 985                 990         


Arg Asp Pro Ala Phe Gly Pro Arg  Gly Met Thr Ala Asn  Thr Val Ile 
        995                 1000                 1005             


Ala Gly  Arg Ser Asp Gly Asp  Gly Glu Asp Ala Gly  Leu Ile Thr 
    1010                 1015                 1020             


Pro Phe  Arg Ala Asn Pro Lys  Ala Ala Val Arg Thr  Met Gly Asn 
    1025                 1030                 1035             


Ala Val  Tyr Glu Val Trp Glu  Ile Gln Val Lys Gly  Arg Pro Arg 
    1040                 1045                 1050             


Trp Thr  His Arg Val Leu Thr  Arg Phe Asp Arg Thr  Gln Pro Ala 
    1055                 1060                 1065             


Pro Pro  Pro Pro Pro Glu Asn  Ala Arg Leu Val Met  Arg Leu Arg 
    1070                 1075                 1080             


Arg Gly  Asp Leu Val Tyr Trp  Pro Leu Glu Ser Gly  Asp Arg Leu 
    1085                 1090                 1095             


Phe Leu  Val Lys Lys Met Ala  Val Asp Gly Arg Leu  Ala Leu Trp 
    1100                 1105                 1110             


Pro Ala  Arg Leu Ala Thr Gly  Lys Ala Thr Ala Leu  Tyr Ala Gln 
    1115                 1120                 1125             


Leu Ser  Cys Pro Asn Ile Asn  Leu Asn Gly Asp Gln  Gly Tyr Cys 
    1130                 1135                 1140             


Val Gln  Ser Ala Glu Gly Ile  Arg Lys Glu Lys Ile  Arg Thr Thr 
    1145                 1150                 1155             


Ser Cys  Thr Ala Leu Gly Arg  Leu Arg Leu Ser Lys  Lys Ala Thr 
    1160                 1165                 1170             


<210>  312
<211>  1147
<212>  PRT
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  312

Met Leu Glu Arg His Pro Gln Arg Tyr Arg Leu Gly Leu Asp Leu Gly 
1               5                   10                  15      


Ser Asn Ser Leu Gly Trp Phe Val Thr Asn Leu Gln Gln Arg Gly Asp 
            20                  25                  30          


Arg Phe Glu Pro Val Gly Leu Gly Pro Gly Gly Val Arg Ile Phe Pro 
        35                  40                  45              


Asp Gly Arg Asp Pro Gln Ser Lys Ala Ser Asn Ala Val Asp Arg Arg 
    50                  55                  60                  


Met Ala Arg Gly Ala Arg Lys Arg Arg Asp Arg Phe Val Gln Arg Arg 
65                  70                  75                  80  


Ser Gln Leu Met Asp Ala Leu Val Arg His Gly Leu Met Pro Glu Glu 
                85                  90                  95      


Ala Ala Ala Arg Lys Ala Leu Ala Gly Leu Asp Pro Tyr Gln Leu Arg 
            100                 105                 110         


Ala Arg Ala Leu Val Asp Arg Leu Pro Ala His His Val Gly Arg Ala 
        115                 120                 125             


Leu Phe His Leu Asn Gln Arg Arg Gly Phe Leu Ser Asn Arg Lys Thr 
    130                 135                 140                 


Asp Asn Lys Lys Asn Ser Glu Asp Gly Ala Ile Lys Gln Ala Ala Ser 
145                 150                 155                 160 


Arg Leu Arg Asp Ser Met Ala Ser Gln Gly Ala Glu Thr Leu Gly Glu 
                165                 170                 175     


Phe Phe Ala Gly Arg Arg His Ser Asp Thr Tyr Ala Glu Arg Gln Thr 
            180                 185                 190         


Ala Ile Arg Ala Glu Leu Gln Arg Ile Gly Lys Asp His Leu Thr Gly 
        195                 200                 205             


Asn Ala Arg Lys Lys Ala Trp Ala Lys Val Arg Lys Arg Leu Phe Gly 
    210                 215                 220                 


Asp Asp Val Leu Asp Pro Ala Met Ala Pro Glu Gly Val Arg Ala Arg 
225                 230                 235                 240 


Ala Ile Ile Thr Gly Thr Lys Ala Ser Tyr Asp Phe Tyr Pro Thr Arg 
                245                 250                 255     


Asp Leu Leu Leu Gln Glu Phe His Ala Ile Trp Arg Ala Gln Ala Pro 
            260                 265                 270         


His His Ser Thr Met Thr Glu Ser Ala Cys Arg Glu Ile Glu Arg Ile 
        275                 280                 285             


Ile Phe Tyr Gln Arg Pro Leu Lys Asp Pro Ile Val Gly Lys Cys Ser 
    290                 295                 300                 


Leu Asp Pro Ala Thr Arg Pro Phe Lys Glu Asp Pro Glu Gly Tyr Arg 
305                 310                 315                 320 


Ala Pro Trp Ala His Pro Leu Ala Gln Arg Phe Arg Ile Leu Ser Glu 
                325                 330                 335     


Ala Arg Asn Leu Glu Ile Arg Glu Thr Gly Arg Gly Ser Arg Lys Leu 
            340                 345                 350         


Thr Lys Ala Gln Ser Asp Val Val Ala Leu Ala Leu Leu Gly Ser Lys 
        355                 360                 365             


Glu Val Lys Phe Asp Lys Leu Arg Thr Leu Leu Lys Leu Pro Ala Glu 
    370                 375                 380                 


Ser Lys Phe Asn Leu Glu Ser Asp Arg Arg Ala Ala Leu Asp Gly Asp 
385                 390                 395                 400 


Ala Thr Ala Ala Arg Leu Ser Asp Lys Asn Gly Phe Gly Lys Ala Trp 
                405                 410                 415     


Arg Gly Phe Pro Leu Glu Arg Gln Val Ala Ile Val Glu Arg Leu Met 
            420                 425                 430         


Thr Val Glu Val Glu Ala Glu Leu Val Asp Trp Leu Glu Gln Glu Cys 
        435                 440                 445             


Gly Leu Gly Pro Glu Ala Ala Ala Arg Val Ala Asn Thr Ser Leu Pro 
    450                 455                 460                 


Glu Gly His Cys Arg Leu Gly Leu Arg Ala Ile Lys Lys Ile Val Pro 
465                 470                 475                 480 


Val Met Gln Asn Glu Val Gly Asp Asp Gly Val Ser Gly Ala Gly Tyr 
                485                 490                 495     


Tyr Glu Ala Ala Lys Arg Ile Gly Tyr Asp His Ala Lys Leu Pro Thr 
            500                 505                 510         


Gly Gly Asp Leu Asp Tyr Leu Pro Tyr Tyr Gly Lys Trp Leu Ala Asp 
        515                 520                 525             


Ala Val Val Gly Ser Gly Asp Ala Arg Asp Gly Lys Glu Arg Gln Phe 
    530                 535                 540                 


Gly Gln Phe Pro Asn Pro Thr Val His Ile Gly Leu Gly Gln Leu Arg 
545                 550                 555                 560 


Arg Leu Val Asn Glu Leu Ile Arg Ala Tyr Gly Pro Pro Thr Glu Ile 
                565                 570                 575     


Ser Ile Glu Phe Thr Arg Ala Leu Arg Leu Ser Glu Asp Gln Lys Ala 
            580                 585                 590         


Gln Val Gln Arg Glu Gln Arg Lys Asn Gln Asp Arg Asn Arg Ala Arg 
        595                 600                 605             


Ala Ala Glu Leu Glu Gln Leu Gly Phe Pro Ala Asn Pro Arg Asn Leu 
    610                 615                 620                 


Leu Lys Met Arg Leu Trp Glu Glu Leu Asn Leu Arg Asp Pro Leu Asp 
625                 630                 635                 640 


Arg Lys Cys Val Tyr Thr Gly Glu Gln Ile Ser Ile Glu Arg Leu Leu 
                645                 650                 655     


Ser Glu Glu Val Asp Ile Asp His Ile Leu Pro Val Ala Met Thr Leu 
            660                 665                 670         


Asp Asp Ser Ala Ala Asn Lys Ile Val Cys Met Arg Tyr Ala Asn Arg 
        675                 680                 685             


His Lys Arg Lys Gln Thr Pro Phe Glu Ala Phe Gly Ser Ser Pro Leu 
    690                 695                 700                 


Val Gln Gly Arg Arg Tyr Ala Trp Asp Asp Ile Ala Thr Arg Ala Ala 
705                 710                 715                 720 


Ala Leu Pro Arg Asn Lys Arg Trp Arg Phe Asp Ala Asp Ala Arg Glu 
                725                 730                 735     


Gln Phe Asp Lys Arg Gly Gly Phe Leu Ala Arg Gln Leu Asn Glu Thr 
            740                 745                 750         


Gly Trp Leu Ala Arg Leu Ala Lys Glu Tyr Leu Gly Ala Val Thr Asp 
        755                 760                 765             


Pro Asn Arg Ile Trp Val Val Pro Gly Arg Leu Thr Gly Leu Leu Arg 
    770                 775                 780                 


Gly Lys Trp Gly Leu Asn Ala Leu Leu Pro Asp His Asn Tyr Ala Gly 
785                 790                 795                 800 


Val Gln Asp Lys Ala Glu Ala Phe Leu Ala Ser Thr Asp Asp Met Glu 
                805                 810                 815     


Phe Ser Gly Val Lys Asn Arg Ala Asp His Arg His His Ala Ile Asp 
            820                 825                 830         


Gly Leu Val Ala Ala Leu Thr Asp Arg Ser Leu Leu Trp Lys Met Ala 
        835                 840                 845             


Asn Ala Tyr Asp Asp Glu Arg Glu Lys Phe Val Val Glu Leu Pro Trp 
    850                 855                 860                 


Pro Thr Met Arg Asp Asp Leu Lys Ala Ala Leu Asp Lys Met Val Val 
865                 870                 875                 880 


Ser His Lys Pro Asp His Gly Val Gln Gly Lys Leu His Glu Asp Ser 
                885                 890                 895     


Ala Tyr Gly Leu Leu Asp Arg Pro Glu Pro Val Glu Asp Asp Asp Arg 
            900                 905                 910         


Glu Pro Ala Asn Leu Val Tyr Arg Lys Ala Val Glu Thr Leu Ser Glu 
        915                 920                 925             


Asn Glu Ile Gly Arg Ile Arg Asp Arg Arg Leu Arg Asp Leu Val Arg 
    930                 935                 940                 


Asp His Val Asp Ala Ala Lys Arg Asn Gly Val Ala Leu Ala Asp Ala 
945                 950                 955                 960 


Leu Arg Gln Leu Thr Glu Pro Ser Asp Asn Pro His Phe Arg His Gly 
                965                 970                 975     


Leu Arg His Val Arg Leu Leu Lys Lys Glu Lys Thr Asp Tyr Leu Val 
            980                 985                 990         


Pro Val Val Asp Arg Ala Thr Gly  Arg Pro Tyr Lys Ala  Tyr Ser Ala 
        995                 1000                 1005             


Gly Glu  Asn Phe Cys Val Glu  Val Phe Glu Thr Ala  Asp Gly Lys 
    1010                 1015                 1020             


Trp Ser  Gly Glu Ala Val Arg  Arg Phe Asp Ala Asn  Arg Ser Asn 
    1025                 1030                 1035             


Cys Gly  Pro Lys Thr Pro His  Val Pro Arg Trp Arg  Thr Glu Ser 
    1040                 1045                 1050             


Ala Gly  Ala Arg Leu Val Met  Arg Ile His Lys Gly  Asp Leu Ile 
    1055                 1060                 1065             


Arg Leu  Glu His Glu Gly Arg  Thr Arg Ile Met Val  Val His Arg 
    1070                 1075                 1080             


Leu Asp  Ala Ala Ala Gly Arg  Phe Lys Leu Ala Ala  His Asn Glu 
    1085                 1090                 1095             


Thr Gly  Asn Leu Asp Lys Arg  His Ala Thr Asp Asn  Asp Ile Asp 
    1100                 1105                 1110             


Pro Phe  Arg Trp Leu Met Ala  Ser Tyr Gly Thr Leu  Lys Lys Met 
    1115                 1120                 1125             


Ala Ala  Val Pro Val Arg Val  Asp Glu Leu Gly Arg  Val Trp Arg 
    1130                 1135                 1140             


Ile Asp  Pro Arg 
    1145         


<210>  313
<211>  1101
<212>  PRT
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  313

Met Trp Tyr Ala Ser Leu Met Ser Ala His His Leu Arg Val Gly Ile 
1               5                   10                  15      


Asp Val Gly Thr His Ser Val Gly Leu Ala Thr Leu Arg Val Asp Asp 
            20                  25                  30          


His Gly Thr Pro Ile Glu Leu Leu Ser Ala Leu Ser His Ile His Asp 
        35                  40                  45              


Ser Gly Val Gly Lys Glu Gly Lys Lys Asp His Asp Thr Arg Lys Lys 
    50                  55                  60                  


Leu Ser Gly Ile Ala Arg Arg Ala Arg Arg Leu Leu His His Arg Arg 
65                  70                  75                  80  


Thr Gln Leu Gln Gln Leu Asp Glu Val Leu Arg Asp Leu Gly Phe Pro 
                85                  90                  95      


Ile Pro Thr Pro Gly Glu Phe Leu Asp Leu Asn Glu Gln Thr Asp Pro 
            100                 105                 110         


Tyr Arg Val Trp Arg Val Arg Ala Arg Leu Val Glu Glu Lys Leu Pro 
        115                 120                 125             


Glu Glu Leu Arg Gly Pro Ala Ile Ser Met Ala Val Arg His Ile Ala 
    130                 135                 140                 


Arg His Arg Gly Trp Arg Asn Pro Tyr Ser Lys Val Glu Ser Leu Leu 
145                 150                 155                 160 


Ser Pro Ala Glu Glu Ser Pro Phe Met Lys Ala Leu Arg Glu Arg Ile 
                165                 170                 175     


Leu Ala Thr Thr Gly Glu Val Leu Asp Asp Gly Ile Thr Pro Gly Gln 
            180                 185                 190         


Ala Met Ala Gln Val Ala Leu Thr His Asn Ile Ser Met Arg Gly Pro 
        195                 200                 205             


Glu Gly Ile Leu Gly Lys Leu His Gln Ser Asp Asn Ala Asn Glu Ile 
    210                 215                 220                 


Arg Lys Ile Cys Ala Arg Gln Gly Val Ser Pro Asp Val Cys Lys Gln 
225                 230                 235                 240 


Leu Leu Arg Ala Val Phe Lys Ala Asp Ser Pro Arg Gly Ser Ala Val 
                245                 250                 255     


Ser Arg Val Ala Pro Asp Pro Leu Pro Gly Gln Gly Ser Phe Arg Arg 
            260                 265                 270         


Ala Pro Lys Cys Asp Pro Glu Phe Gln Arg Phe Arg Ile Ile Ser Ile 
        275                 280                 285             


Val Ala Asn Leu Arg Ile Ser Glu Thr Lys Gly Glu Asn Arg Pro Leu 
    290                 295                 300                 


Thr Ala Asp Glu Arg Arg His Val Val Thr Phe Leu Thr Glu Asp Ser 
305                 310                 315                 320 


Gln Ala Asp Leu Thr Trp Val Asp Val Ala Glu Lys Leu Gly Val His 
                325                 330                 335     


Arg Arg Asp Leu Arg Gly Thr Ala Val His Thr Asp Asp Gly Glu Arg 
            340                 345                 350         


Ser Ala Ala Arg Pro Pro Ile Asp Ala Thr Asp Arg Ile Met Arg Gln 
        355                 360                 365             


Thr Lys Ile Ser Ser Leu Lys Thr Trp Trp Glu Glu Ala Asp Ser Glu 
    370                 375                 380                 


Gln Arg Gly Ala Met Ile Arg Tyr Leu Tyr Glu Asp Pro Thr Asp Ser 
385                 390                 395                 400 


Glu Cys Ala Glu Ile Ile Ala Glu Leu Pro Glu Glu Asp Gln Ala Lys 
                405                 410                 415     


Leu Asp Ser Leu His Leu Pro Ala Gly Arg Ala Ala Tyr Ser Arg Glu 
            420                 425                 430         


Ser Leu Thr Ala Leu Ser Asp His Met Leu Ala Thr Thr Asp Asp Leu 
        435                 440                 445             


His Glu Ala Arg Lys Arg Leu Phe Gly Val Asp Asp Ser Trp Ala Pro 
    450                 455                 460                 


Pro Ala Glu Ala Ile Asn Ala Pro Val Gly Asn Pro Ser Val Asp Arg 
465                 470                 475                 480 


Thr Leu Lys Ile Val Gly Arg Tyr Leu Ser Ala Val Glu Ser Met Trp 
                485                 490                 495     


Gly Thr Pro Glu Val Ile His Val Glu His Val Arg Asp Gly Phe Thr 
            500                 505                 510         


Ser Glu Arg Met Ala Asp Glu Arg Asp Lys Ala Asn Arg Arg Arg Tyr 
        515                 520                 525             


Asn Asp Asn Gln Glu Ala Met Lys Lys Ile Gln Arg Asp Tyr Gly Lys 
    530                 535                 540                 


Glu Gly Tyr Ile Ser Arg Gly Asp Ile Val Arg Leu Asp Ala Leu Glu 
545                 550                 555                 560 


Leu Gln Gly Cys Ala Cys Leu Tyr Cys Gly Thr Thr Ile Gly Tyr His 
                565                 570                 575     


Thr Cys Gln Leu Asp His Ile Val Pro Gln Ala Gly Pro Gly Ser Asn 
            580                 585                 590         


Asn Arg Arg Gly Asn Leu Val Ala Val Cys Glu Arg Cys Asn Arg Ser 
        595                 600                 605             


Lys Ser Asn Thr Pro Phe Ala Val Trp Ala Gln Lys Cys Gly Ile Pro 
    610                 615                 620                 


His Val Gly Val Lys Glu Ala Ile Gly Arg Val Arg Gly Trp Arg Lys 
625                 630                 635                 640 


Gln Thr Pro Asn Thr Ser Ser Glu Asp Leu Thr Arg Leu Lys Lys Glu 
                645                 650                 655     


Val Ile Ala Arg Leu Arg Arg Thr Gln Glu Asp Pro Glu Ile Asp Glu 
            660                 665                 670         


Arg Ser Met Glu Ser Val Ala Trp Met Ala Asn Glu Leu His His Arg 
        675                 680                 685             


Ile Ala Ala Ala Tyr Pro Glu Thr Thr Val Met Val Tyr Arg Gly Ser 
    690                 695                 700                 


Ile Thr Ala Ala Ala Arg Lys Ala Ala Gly Ile Asp Ser Arg Ile Asn 
705                 710                 715                 720 


Leu Ile Gly Glu Lys Gly Arg Lys Asp Arg Ile Asp Arg Arg His His 
                725                 730                 735     


Ala Val Asp Ala Ser Val Val Ala Leu Met Glu Ala Ser Val Ala Lys 
            740                 745                 750         


Thr Leu Ala Glu Arg Ser Ser Leu Arg Gly Glu Gln Arg Leu Thr Gly 
        755                 760                 765             


Lys Glu Gln Thr Trp Lys Gln Tyr Thr Gly Ser Thr Val Gly Ala Arg 
    770                 775                 780                 


Glu His Phe Glu Met Trp Arg Gly His Met Leu His Leu Thr Glu Leu 
785                 790                 795                 800 


Phe Asn Glu Arg Leu Ala Glu Asp Lys Val Tyr Val Thr Gln Asn Ile 
                805                 810                 815     


Arg Leu Arg Leu Ser Asp Gly Asn Ala His Thr Val Asn Pro Ser Lys 
            820                 825                 830         


Leu Val Ser His Arg Leu Gly Asp Gly Leu Thr Val Gln Gln Ile Asp 
        835                 840                 845             


Arg Ala Cys Thr Pro Ala Leu Trp Cys Ala Leu Thr Arg Glu Lys Asp 
    850                 855                 860                 


Phe Asp Glu Lys Asn Gly Leu Pro Ala Arg Glu Asp Arg Ala Ile Arg 
865                 870                 875                 880 


Val His Gly His Glu Ile Lys Ser Ser Asp Tyr Ile Gln Val Phe Ser 
                885                 890                 895     


Lys Arg Lys Lys Thr Asp Ser Asp Arg Asp Glu Thr Pro Phe Gly Ala 
            900                 905                 910         


Ile Ala Val Arg Gly Gly Phe Val Glu Ile Gly Pro Ser Ile His His 
        915                 920                 925             


Ala Arg Ile Tyr Arg Val Glu Gly Lys Lys Pro Val Tyr Ala Met Leu 
    930                 935                 940                 


Arg Val Phe Thr His Asp Leu Leu Ser Gln Arg His Gly Asp Leu Phe 
945                 950                 955                 960 


Ser Ala Val Ile Pro Pro Gln Ser Ile Ser Met Arg Cys Ala Glu Pro 
                965                 970                 975     


Lys Leu Arg Lys Ala Ile Thr Thr Gly Asn Ala Thr Tyr Leu Gly Trp 
            980                 985                 990         


Val Val Val Gly Asp Glu Leu Glu  Ile Asn Val Asp Ser  Phe Thr Lys 
        995                 1000                 1005             


Tyr Ala  Ile Gly Arg Phe Leu  Glu Asp Phe Pro Asn  Thr Thr Arg 
    1010                 1015                 1020             


Trp Arg  Ile Cys Gly Tyr Asp  Thr Asn Ser Lys Leu  Thr Leu Lys 
    1025                 1030                 1035             


Pro Ile  Val Leu Ala Ala Glu  Gly Leu Glu Asn Pro  Ser Ser Ala 
    1040                 1045                 1050             


Val Asn  Glu Ile Val Glu Leu  Lys Gly Trp Arg Val  Ala Ile Asn 
    1055                 1060                 1065             


Val Leu  Thr Lys Val His Pro  Thr Val Val Arg Arg  Asp Ala Leu 
    1070                 1075                 1080             


Gly Arg  Pro Arg Tyr Ser Ser  Arg Ser Asn Leu Pro  Thr Ser Trp 
    1085                 1090                 1095             


Thr Ile  Glu 
    1100     


<210>  314

<400>  314
000

<210>  315

<400>  315
000

<210>  316

<400>  316
000

<210>  317

<400>  317
000

<210>  318

<400>  318
000

<210>  319

<400>  319
000

<210>  320

<400>  320
000

<210>  321
<211>  4140
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  321
auggacaaga aguacagcau cggacuggac aucggaacaa acagcgucgg augggcaguc       60

aucacagacg aauacaaggu cccgagcaag aaguucaagg uccugggaaa cacagacaga      120

cacagcauca agaagaaccu gaucggagca cugcuguucg acagcggaga aacagcagaa      180

gcaacaagac ugaagagaac agcaagaaga agauacacaa gaagaaagaa cagaaucugc      240

uaccugcagg aaaucuucag caacgaaaug gcaaaggucg acgacagcuu cuuccacaga      300

cuggaagaaa gcuuccuggu cgaagaagac aagaagcacg aaagacaccc gaucuucgga      360

aacaucgucg acgaagucgc auaccacgaa aaguacccga caaucuacca ccugagaaag      420

aagcuggucg acagcacaga caaggcagac cugagacuga ucuaccuggc acuggcacac      480

augaucaagu ucagaggaca cuuccugauc gaaggagacc ugaacccgga caacagcgac      540

gucgacaagc uguucaucca gcugguccag acauacaacc agcuguucga agaaaacccg      600

aucaacgcaa gcggagucga cgcaaaggca auccugagcg caagacugag caagagcaga      660

agacuggaaa accugaucgc acagcugccg ggagaaaaga agaacggacu guucggaaac      720

cugaucgcac ugagccuggg acugacaccg aacuucaaga gcaacuucga ccuggcagaa      780

gacgcaaagc ugcagcugag caaggacaca uacgacgacg accuggacaa ccugcuggca      840

cagaucggag accaguacgc agaccuguuc cuggcagcaa agaaccugag cgacgcaauc      900

cugcugagcg acauccugag agucaacaca gaaaucacaa aggcaccgcu gagcgcaagc      960

augaucaaga gauacgacga acaccaccag gaccugacac ugcugaaggc acuggucaga     1020

cagcagcugc cggaaaagua caaggaaauc uucuucgacc agagcaagaa cggauacgca     1080

ggauacaucg acggaggagc aagccaggaa gaauucuaca aguucaucaa gccgauccug     1140

gaaaagaugg acggaacaga agaacugcug gucaagcuga acagagaaga ccugcugaga     1200

aagcagagaa cauucgacaa cggaagcauc ccgcaccaga uccaccuggg agaacugcac     1260

gcaauccuga gaagacagga agacuucuac ccguuccuga aggacaacag agaaaagauc     1320

gaaaagaucc ugacauucag aaucccguac uacgucggac cgcuggcaag aggaaacagc     1380

agauucgcau ggaugacaag aaagagcgaa gaaacaauca caccguggaa cuucgaagaa     1440

gucgucgaca agggagcaag cgcacagagc uucaucgaaa gaaugacaaa cuucgacaag     1500

aaccugccga acgaaaaggu ccugccgaag cacagccugc uguacgaaua cuucacaguc     1560

uacaacgaac ugacaaaggu caaguacguc acagaaggaa ugagaaagcc ggcauuccug     1620

agcggagaac agaagaaggc aaucgucgac cugcuguuca agacaaacag aaaggucaca     1680

gucaagcagc ugaaggaaga cuacuucaag aagaucgaau gcuucgacag cgucgaaauc     1740

agcggagucg aagacagauu caacgcaagc cugggaacau accacgaccu gcugaagauc     1800

aucaaggaca aggacuuccu ggacaacgaa gaaaacgaag acauccugga agacaucguc     1860

cugacacuga cacuguucga agacagagaa augaucgaag aaagacugaa gacauacgca     1920

caccuguucg acgacaaggu caugaagcag cugaagagaa gaagauacac aggaugggga     1980

agacugagca gaaagcugau caacggaauc agagacaagc agagcggaaa gacaauccug     2040

gacuuccuga agagcgacgg auucgcaaac agaaacuuca ugcagcugau ccacgacgac     2100

agccugacau ucaaggaaga cauccagaag gcacagguca gcggacaggg agacagccug     2160

cacgaacaca ucgcaaaccu ggcaggaagc ccggcaauca agaagggaau ccugcagaca     2220

gucaaggucg ucgacgaacu ggucaagguc augggaagac acaagccgga aaacaucguc     2280

aucgaaaugg caagagaaaa ccagacaaca cagaagggac agaagaacag cagagaaaga     2340

augaagagaa ucgaagaagg aaucaaggaa cugggaagcc agauccugaa ggaacacccg     2400

gucgaaaaca cacagcugca gaacgaaaag cuguaccugu acuaccugca gaacggaaga     2460

gacauguacg ucgaccagga acuggacauc aacagacuga gcgacuacga cgucgaccac     2520

aucgucccgc agagcuuccu gaaggacgac agcaucgaca acaagguccu gacaagaagc     2580

gacaagaaca gaggaaagag cgacaacguc ccgagcgaag aagucgucaa gaagaugaag     2640

aacuacugga gacagcugcu gaacgcaaag cugaucacac agagaaaguu cgacaaccug     2700

acaaaggcag agagaggagg acugagcgaa cuggacaagg caggauucau caagagacag     2760

cuggucgaaa caagacagau cacaaagcac gucgcacaga uccuggacag cagaaugaac     2820

acaaaguacg acgaaaacga caagcugauc agagaaguca aggucaucac acugaagagc     2880

aagcugguca gcgacuucag aaaggacuuc caguucuaca aggucagaga aaucaacaac     2940

uaccaccacg cacacgacgc auaccugaac gcagucgucg gaacagcacu gaucaagaag     3000

uacccgaagc uggaaagcga auucgucuac ggagacuaca aggucuacga cgucagaaag     3060

augaucgcaa agagcgaaca ggaaaucgga aaggcaacag caaaguacuu cuucuacagc     3120

aacaucauga acuucuucaa gacagaaauc acacuggcaa acggagaaau cagaaagaga     3180

ccgcugaucg aaacaaacgg agaaacagga gaaaucgucu gggacaaggg aagagacuuc     3240

gcaacaguca gaaagguccu gagcaugccg caggucaaca ucgucaagaa gacagaaguc     3300

cagacaggag gauucagcaa ggaaagcauc cugccgaaga gaaacagcga caagcugauc     3360

gcaagaaaga aggacuggga cccgaagaag uacggaggau ucgacagccc gacagucgca     3420

uacagcgucc uggucgucgc aaaggucgaa aagggaaaga gcaagaagcu gaagagcguc     3480

aaggaacugc ugggaaucac aaucauggaa agaagcagcu ucgaaaagaa cccgaucgac     3540

uuccuggaag caaagggaua caaggaaguc aagaaggacc ugaucaucaa gcugccgaag     3600

uacagccugu ucgaacugga aaacggaaga aagagaaugc uggcaagcgc aggagaacug     3660

cagaagggaa acgaacuggc acugccgagc aaguacguca acuuccugua ccuggcaagc     3720

cacuacgaaa agcugaaggg aagcccggaa gacaacgaac agaagcagcu guucgucgaa     3780

cagcacaagc acuaccugga cgaaaucauc gaacagauca gcgaauucag caagagaguc     3840

auccuggcag acgcaaaccu ggacaagguc cugagcgcau acaacaagca cagagacaag     3900

ccgaucagag aacaggcaga aaacaucauc caccuguuca cacugacaaa ccugggagca     3960

ccggcagcau ucaaguacuu cgacacaaca aucgacagaa agagauacac aagcacaaag     4020

gaaguccugg acgcaacacu gauccaccag agcaucacag gacuguacga aacaagaauc     4080

gaccugagcc agcugggagg agacggagga ggaagcccga agaagaagag aaaggucuag     4140


<210>  322
<211>  4140
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  322
auggacaaga aguacuccau cggccuggac aucggcacca acuccguggg cugggccgug       60

aucaccgacg aguacaaggu gcccuccaag aaguucaagg ugcugggcaa caccgaccgg      120

cacuccauca agaagaaccu gaucggcgcc cugcuguucg acuccggcga gaccgccgag      180

gccacccggc ugaagcggac cgcccggcgg cgguacaccc ggcggaagaa ccggaucugc      240

uaccugcagg agaucuucuc caacgagaug gccaaggugg acgacuccuu cuuccaccgg      300

cuggaggagu ccuuccuggu ggaggaggac aagaagcacg agcggcaccc caucuucggc      360

aacaucgugg acgagguggc cuaccacgag aaguacccca ccaucuacca ccugcggaag      420

aagcuggugg acuccaccga caaggccgac cugcggcuga ucuaccuggc ccuggcccac      480

augaucaagu uccggggcca cuuccugauc gagggcgacc ugaaccccga caacuccgac      540

guggacaagc uguucaucca gcuggugcag accuacaacc agcuguucga ggagaacccc      600

aucaacgccu ccggcgugga cgccaaggcc auccuguccg cccggcuguc caagucccgg      660

cggcuggaga accugaucgc ccagcugccc ggcgagaaga agaacggccu guucggcaac      720

cugaucgccc ugucccuggg ccugaccccc aacuucaagu ccaacuucga ccuggccgag      780

gacgccaagc ugcagcuguc caaggacacc uacgacgacg accuggacaa ccugcuggcc      840

cagaucggcg accaguacgc cgaccuguuc cuggccgcca agaaccuguc cgacgccauc      900

cugcuguccg acauccugcg ggugaacacc gagaucacca aggccccccu guccgccucc      960

augaucaagc gguacgacga gcaccaccag gaccugaccc ugcugaaggc ccuggugcgg     1020

cagcagcugc ccgagaagua caaggagauc uucuucgacc aguccaagaa cggcuacgcc     1080

ggcuacaucg acggcggcgc cucccaggag gaguucuaca aguucaucaa gcccauccug     1140

gagaagaugg acggcaccga ggagcugcug gugaagcuga accgggagga ccugcugcgg     1200

aagcagcgga ccuucgacaa cggcuccauc ccccaccaga uccaccuggg cgagcugcac     1260

gccauccugc ggcggcagga ggacuucuac cccuuccuga aggacaaccg ggagaagauc     1320

gagaagaucc ugaccuuccg gauccccuac uacgugggcc cccuggcccg gggcaacucc     1380

cgguucgccu ggaugacccg gaaguccgag gagaccauca cccccuggaa cuucgaggag     1440

gugguggaca agggcgccuc cgcccagucc uucaucgagc ggaugaccaa cuucgacaag     1500

aaccugccca acgagaaggu gcugcccaag cacucccugc uguacgagua cuucaccgug     1560

uacaacgagc ugaccaaggu gaaguacgug accgagggca ugcggaagcc cgccuuccug     1620

uccggcgagc agaagaaggc caucguggac cugcuguuca agaccaaccg gaaggugacc     1680

gugaagcagc ugaaggagga cuacuucaag aagaucgagu gcuucgacuc cguggagauc     1740

uccggcgugg aggaccgguu caacgccucc cugggcaccu accacgaccu gcugaagauc     1800

aucaaggaca aggacuuccu ggacaacgag gagaacgagg acauccugga ggacaucgug     1860

cugacccuga cccuguucga ggaccgggag augaucgagg agcggcugaa gaccuacgcc     1920

caccuguucg acgacaaggu gaugaagcag cugaagcggc ggcgguacac cggcuggggc     1980

cggcuguccc ggaagcugau caacggcauc cgggacaagc aguccggcaa gaccauccug     2040

gacuuccuga aguccgacgg cuucgccaac cggaacuuca ugcagcugau ccacgacgac     2100

ucccugaccu ucaaggagga cauccagaag gcccaggugu ccggccaggg cgacucccug     2160

cacgagcaca ucgccaaccu ggccggcucc cccgccauca agaagggcau ccugcagacc     2220

gugaaggugg uggacgagcu ggugaaggug augggccggc acaagcccga gaacaucgug     2280

aucgagaugg cccgggagaa ccagaccacc cagaagggcc agaagaacuc ccgggagcgg     2340

augaagcgga ucgaggaggg caucaaggag cugggcuccc agauccugaa ggagcacccc     2400

guggagaaca cccagcugca gaacgagaag cuguaccugu acuaccugca gaacggccgg     2460

gacauguacg uggaccagga gcuggacauc aaccggcugu ccgacuacga cguggaccac     2520

aucgugcccc aguccuuccu gaaggacgac uccaucgaca acaaggugcu gacccggucc     2580

gacaagaacc ggggcaaguc cgacaacgug cccuccgagg agguggugaa gaagaugaag     2640

aacuacuggc ggcagcugcu gaacgccaag cugaucaccc agcggaaguu cgacaaccug     2700

accaaggccg agcggggcgg ccuguccgag cuggacaagg ccggcuucau caagcggcag     2760

cugguggaga cccggcagau caccaagcac guggcccaga uccuggacuc ccggaugaac     2820

accaaguacg acgagaacga caagcugauc cgggagguga aggugaucac ccugaagucc     2880

aagcuggugu ccgacuuccg gaaggacuuc caguucuaca aggugcggga gaucaacaac     2940

uaccaccacg cccacgacgc cuaccugaac gccguggugg gcaccgcccu gaucaagaag     3000

uaccccaagc uggaguccga guucguguac ggcgacuaca agguguacga cgugcggaag     3060

augaucgcca aguccgagca ggagaucggc aaggccaccg ccaaguacuu cuucuacucc     3120

aacaucauga acuucuucaa gaccgagauc acccuggcca acggcgagau ccggaagcgg     3180

ccccugaucg agaccaacgg cgagaccggc gagaucgugu gggacaaggg ccgggacuuc     3240

gccaccgugc ggaaggugcu guccaugccc caggugaaca ucgugaagaa gaccgaggug     3300

cagaccggcg gcuucuccaa ggaguccauc cugcccaagc ggaacuccga caagcugauc     3360

gcccggaaga aggacuggga ccccaagaag uacggcggcu ucgacucccc caccguggcc     3420

uacuccgugc uggugguggc caagguggag aagggcaagu ccaagaagcu gaaguccgug     3480

aaggagcugc ugggcaucac caucauggag cgguccuccu ucgagaagaa ccccaucgac     3540

uuccuggagg ccaagggcua caaggaggug aagaaggacc ugaucaucaa gcugcccaag     3600

uacucccugu ucgagcugga gaacggccgg aagcggaugc uggccuccgc cggcgagcug     3660

cagaagggca acgagcuggc ccugcccucc aaguacguga acuuccugua ccuggccucc     3720

cacuacgaga agcugaaggg cucccccgag gacaacgagc agaagcagcu guucguggag     3780

cagcacaagc acuaccugga cgagaucauc gagcagaucu ccgaguucuc caagcgggug     3840

auccuggccg acgccaaccu ggacaaggug cuguccgccu acaacaagca ccgggacaag     3900

cccauccggg agcaggccga gaacaucauc caccuguuca cccugaccaa ccugggcgcc     3960

cccgccgccu ucaaguacuu cgacaccacc aucgaccgga agcgguacac cuccaccaag     4020

gaggugcugg acgccacccu gauccaccag uccaucaccg gccuguacga gacccggauc     4080

gaccuguccc agcugggcgg cgacggcggc ggcuccccca agaagaagcg gaagguguga     4140


<210>  323
<211>  4197
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  323
auggacaaga aguacuccau cggccuggac aucggcacca acuccguggg cugggccgug       60

aucaccgacg aguacaaggu gcccuccaag aaguucaagg ugcugggcaa caccgaccgg      120

cacuccauca agaagaaccu gaucggcgcc cugcuguucg acuccggcga gaccgccgag      180

gccacccggc ugaagcggac cgcccggcgg cgguacaccc ggcggaagaa ccggaucugc      240

uaccugcagg agaucuucuc caacgagaug gccaaggugg acgacuccuu cuuccaccgg      300

cuggaggagu ccuuccuggu ggaggaggac aagaagcacg agcggcaccc caucuucggc      360

aacaucgugg acgagguggc cuaccacgag aaguacccca ccaucuacca ccugcggaag      420

aagcuggugg acuccaccga caaggccgac cugcggcuga ucuaccuggc ccuggcccac      480

augaucaagu uccggggcca cuuccugauc gagggcgacc ugaaccccga caacuccgac      540

guggacaagc uguucaucca gcuggugcag accuacaacc agcuguucga ggagaacccc      600

aucaacgccu ccggcgugga cgccaaggcc auccuguccg cccggcuguc caagucccgg      660

cggcuggaga accugaucgc ccagcugccc ggcgagaaga agaacggccu guucggcaac      720

cugaucgccc ugucccuggg ccugaccccc aacuucaagu ccaacuucga ccuggccgag      780

gacgccaagc ugcagcuguc caaggacacc uacgacgacg accuggacaa ccugcuggcc      840

cagaucggcg accaguacgc cgaccuguuc cuggccgcca agaaccuguc cgacgccauc      900

cugcuguccg acauccugcg ggugaacacc gagaucacca aggccccccu guccgccucc      960

augaucaagc gguacgacga gcaccaccag gaccugaccc ugcugaaggc ccuggugcgg     1020

cagcagcugc ccgagaagua caaggagauc uucuucgacc aguccaagaa cggcuacgcc     1080

ggcuacaucg acggcggcgc cucccaggag gaguucuaca aguucaucaa gcccauccug     1140

gagaagaugg acggcaccga ggagcugcug gugaagcuga accgggagga ccugcugcgg     1200

aagcagcgga ccuucgacaa cggcuccauc ccccaccaga uccaccuggg cgagcugcac     1260

gccauccugc ggcggcagga ggacuucuac cccuuccuga aggacaaccg ggagaagauc     1320

gagaagaucc ugaccuuccg gauccccuac uacgugggcc cccuggcccg gggcaacucc     1380

cgguucgccu ggaugacccg gaaguccgag gagaccauca cccccuggaa cuucgaggag     1440

gugguggaca agggcgccuc cgcccagucc uucaucgagc ggaugaccaa cuucgacaag     1500

aaccugccca acgagaaggu gcugcccaag cacucccugc uguacgagua cuucaccgug     1560

uacaacgagc ugaccaaggu gaaguacgug accgagggca ugcggaagcc cgccuuccug     1620

uccggcgagc agaagaaggc caucguggac cugcuguuca agaccaaccg gaaggugacc     1680

gugaagcagc ugaaggagga cuacuucaag aagaucgagu gcuucgacuc cguggagauc     1740

uccggcgugg aggaccgguu caacgccucc cugggcaccu accacgaccu gcugaagauc     1800

aucaaggaca aggacuuccu ggacaacgag gagaacgagg acauccugga ggacaucgug     1860

cugacccuga cccuguucga ggaccgggag augaucgagg agcggcugaa gaccuacgcc     1920

caccuguucg acgacaaggu gaugaagcag cugaagcggc ggcgguacac cggcuggggc     1980

cggcuguccc ggaagcugau caacggcauc cgggacaagc aguccggcaa gaccauccug     2040

gacuuccuga aguccgacgg cuucgccaac cggaacuuca ugcagcugau ccacgacgac     2100

ucccugaccu ucaaggagga cauccagaag gcccaggugu ccggccaggg cgacucccug     2160

cacgagcaca ucgccaaccu ggccggcucc cccgccauca agaagggcau ccugcagacc     2220

gugaaggugg uggacgagcu ggugaaggug augggccggc acaagcccga gaacaucgug     2280

aucgagaugg cccgggagaa ccagaccacc cagaagggcc agaagaacuc ccgggagcgg     2340

augaagcgga ucgaggaggg caucaaggag cugggcuccc agauccugaa ggagcacccc     2400

guggagaaca cccagcugca gaacgagaag cuguaccugu acuaccugca gaacggccgg     2460

gacauguacg uggaccagga gcuggacauc aaccggcugu ccgacuacga cguggaccac     2520

aucgugcccc aguccuuccu gaaggacgac uccaucgaca acaaggugcu gacccggucc     2580

gacaagaacc ggggcaaguc cgacaacgug cccuccgagg agguggugaa gaagaugaag     2640

aacuacuggc ggcagcugcu gaacgccaag cugaucaccc agcggaaguu cgacaaccug     2700

accaaggccg agcggggcgg ccuguccgag cuggacaagg ccggcuucau caagcggcag     2760

cugguggaga cccggcagau caccaagcac guggcccaga uccuggacuc ccggaugaac     2820

accaaguacg acgagaacga caagcugauc cgggagguga aggugaucac ccugaagucc     2880

aagcuggugu ccgacuuccg gaaggacuuc caguucuaca aggugcggga gaucaacaac     2940

uaccaccacg cccacgacgc cuaccugaac gccguggugg gcaccgcccu gaucaagaag     3000

uaccccaagc uggaguccga guucguguac ggcgacuaca agguguacga cgugcggaag     3060

augaucgcca aguccgagca ggagaucggc aaggccaccg ccaaguacuu cuucuacucc     3120

aacaucauga acuucuucaa gaccgagauc acccuggcca acggcgagau ccggaagcgg     3180

ccccugaucg agaccaacgg cgagaccggc gagaucgugu gggacaaggg ccgggacuuc     3240

gccaccgugc ggaaggugcu guccaugccc caggugaaca ucgugaagaa gaccgaggug     3300

cagaccggcg gcuucuccaa ggaguccauc cugcccaagc ggaacuccga caagcugauc     3360

gcccggaaga aggacuggga ccccaagaag uacggcggcu ucgacucccc caccguggcc     3420

uacuccgugc uggugguggc caagguggag aagggcaagu ccaagaagcu gaaguccgug     3480

aaggagcugc ugggcaucac caucauggag cgguccuccu ucgagaagaa ccccaucgac     3540

uuccuggagg ccaagggcua caaggaggug aagaaggacc ugaucaucaa gcugcccaag     3600

uacucccugu ucgagcugga gaacggccgg aagcggaugc uggccuccgc cggcgagcug     3660

cagaagggca acgagcuggc ccugcccucc aaguacguga acuuccugua ccuggccucc     3720

cacuacgaga agcugaaggg cucccccgag gacaacgagc agaagcagcu guucguggag     3780

cagcacaagc acuaccugga cgagaucauc gagcagaucu ccgaguucuc caagcgggug     3840

auccuggccg acgccaaccu ggacaaggug cuguccgccu acaacaagca ccgggacaag     3900

cccauccggg agcaggccga gaacaucauc caccuguuca cccugaccaa ccugggcgcc     3960

cccgccgccu ucaaguacuu cgacaccacc aucgaccgga agcgguacac cuccaccaag     4020

gaggugcugg acgccacccu gauccaccag uccaucaccg gccuguacga gacccggauc     4080

gaccuguccc agcugggcgg cgacggcggc ggcuccccca agaagaagcg gaaggugucc     4140

gaguccgcca cccccgaguc cguguccggc uggcggcugu ucaagaagau cuccuga        4197


<210>  324

<400>  324
000

<210>  325

<400>  325
000

<210>  326

<400>  326
000

<210>  327

<400>  327
000

<210>  328

<400>  328
000

<210>  329

<400>  329
000

<210>  330

<400>  330
000

<210>  331

<400>  331
000

<210>  332

<400>  332
000

<210>  333

<400>  333
000

<210>  334

<400>  334
000

<210>  335

<400>  335
000

<210>  336

<400>  336
000

<210>  337

<400>  337
000

<210>  338

<400>  338
000

<210>  339

<400>  339
000

<210>  340

<400>  340
000

<210>  341

<400>  341
000

<210>  342

<400>  342
000

<210>  343

<400>  343
000

<210>  344

<400>  344
000

<210>  345

<400>  345
000

<210>  346

<400>  346
000

<210>  347

<400>  347
000

<210>  348

<400>  348
000

<210>  349

<400>  349
000

<210>  350
<211>  1105
<212>  PRT
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  350

Met Thr Gly Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly 
1               5                   10                  15      


Leu Asp Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp 
            20                  25                  30          


Glu Glu Glu Asn Pro Ile Arg Leu Ile Asp Leu Gly Val Arg Val Phe 
        35                  40                  45              


Glu Arg Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg 
    50                  55                  60                  


Arg Leu Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg 
65                  70                  75                  80  


Leu Leu Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala 
                85                  90                  95      


Ala Asp Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro 
            100                 105                 110         


Trp Gln Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu 
        115                 120                 125             


Trp Ser Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser 
    130                 135                 140                 


Gln Arg Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu 
145                 150                 155                 160 


Leu Lys Gly Val Ala Asn Asn Ala His Ala Leu Gln Thr Gly Asp Phe 
                165                 170                 175     


Arg Thr Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly 
            180                 185                 190         


His Ile Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys 
        195                 200                 205             


Asp Leu Gln Ala Glu Leu Ile Leu Leu Phe Glu Lys Gln Lys Glu Phe 
    210                 215                 220                 


Gly Asn Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu 
225                 230                 235                 240 


Leu Met Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met 
                245                 250                 255     


Leu Gly His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn 
            260                 265                 270         


Thr Tyr Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu 
        275                 280                 285             


Arg Ile Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg 
    290                 295                 300                 


Ala Thr Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala 
305                 310                 315                 320 


Gln Ala Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly 
                325                 330                 335     


Leu Arg Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met 
            340                 345                 350         


Lys Ala Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys 
        355                 360                 365             


Asp Lys Lys Ser Pro Leu Asn Leu Ser Ser Glu Leu Gln Asp Glu Ile 
    370                 375                 380                 


Gly Thr Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg 
385                 390                 395                 400 


Leu Lys Asp Arg Val Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His 
                405                 410                 415     


Ile Ser Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg 
            420                 425                 430         


Ile Val Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala 
        435                 440                 445             


Glu Ile Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile 
    450                 455                 460                 


Tyr Leu Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu 
465                 470                 475                 480 


Arg Ala Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg 
                485                 490                 495     


Tyr Gly Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly 
            500                 505                 510         


Lys Ser Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn 
        515                 520                 525             


Arg Lys Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro 
    530                 535                 540                 


Asn Phe Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu 
545                 550                 555                 560 


Tyr Glu Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn 
                565                 570                 575     


Leu Val Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu 
            580                 585                 590         


Pro Phe Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val 
        595                 600                 605             


Leu Gly Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr 
    610                 615                 620                 


Phe Asn Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg 
625                 630                 635                 640 


Val Glu Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu 
                645                 650                 655     


Gln Lys Phe Asp Glu Asp Gly Phe Lys Glu Cys Asn Leu Asn Asp Thr 
            660                 665                 670         


Arg Tyr Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp His Ile Leu 
        675                 680                 685             


Leu Thr Gly Lys Gly Lys Arg Arg Val Phe Ala Ser Asn Gly Gln Ile 
    690                 695                 700                 


Thr Asn Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu 
705                 710                 715                 720 


Asn Asp Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr 
                725                 730                 735     


Val Ala Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met 
            740                 745                 750         


Asn Ala Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Lys Val Leu 
        755                 760                 765             


His Gln Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu 
    770                 775                 780                 


Val Met Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu 
785                 790                 795                 800 


Glu Ala Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu 
                805                 810                 815     


Ser Ser Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val 
            820                 825                 830         


Ser Arg Ala Pro Asn Arg Lys Met Ser Gly Ala His Lys Asp Thr Leu 
        835                 840                 845             


Arg Ser Ala Lys Arg Phe Val Lys His Asn Glu Lys Ile Ser Val Lys 
    850                 855                 860                 


Arg Val Trp Leu Thr Glu Ile Lys Leu Ala Asp Leu Glu Asn Met Val 
865                 870                 875                 880 


Asn Tyr Lys Asn Gly Arg Glu Ile Glu Leu Tyr Glu Ala Leu Lys Ala 
                885                 890                 895     


Arg Leu Glu Ala Tyr Gly Gly Asn Ala Lys Gln Ala Phe Asp Pro Lys 
            900                 905                 910         


Asp Asn Pro Phe Tyr Lys Lys Gly Gly Gln Leu Val Lys Ala Val Arg 
        915                 920                 925             


Val Glu Lys Thr Gln Glu Ser Gly Val Leu Leu Asn Lys Lys Asn Ala 
    930                 935                 940                 


Tyr Thr Ile Ala Asp Asn Gly Asp Met Val Arg Val Asp Val Phe Cys 
945                 950                 955                 960 


Lys Val Asp Lys Lys Gly Lys Asn Gln Tyr Phe Ile Val Pro Ile Tyr 
                965                 970                 975     


Ala Trp Gln Val Ala Glu Asn Ile Leu Pro Asp Ile Asp Cys Lys Gly 
            980                 985                 990         


Tyr Arg Ile Asp Asp Ser Tyr Thr  Phe Cys Phe Ser Leu  His Lys Tyr 
        995                 1000                 1005             


Asp Leu  Ile Ala Phe Gln Lys  Asp Glu Lys Ser Lys  Val Glu Phe 
    1010                 1015                 1020             


Ala Tyr  Tyr Ile Asn Cys Asp  Ser Ser Asn Gly Arg  Phe Tyr Leu 
    1025                 1030                 1035             


Ala Trp  His Asp Lys Gly Ser  Lys Glu Gln Gln Phe  Arg Ile Ser 
    1040                 1045                 1050             


Thr Gln  Asn Leu Val Leu Ile  Gln Lys Tyr Gln Val  Asn Glu Leu 
    1055                 1060                 1065             


Gly Lys  Glu Ile Arg Pro Cys  Arg Leu Lys Lys Arg  Pro Pro Val 
    1070                 1075                 1080             


Arg Ser  Gly Lys Arg Thr Ala  Asp Gly Ser Glu Phe  Glu Ser Pro 
    1085                 1090                 1095             


Lys Lys  Lys Arg Lys Val Glu  
    1100                 1105 


<210>  351
<211>  107
<212>  PRT
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  351

Met Thr Asn Leu Ser Asp Ile Ile Glu Lys Glu Thr Gly Lys Gln Leu 
1               5                   10                  15      


Val Ile Gln Glu Ser Ile Leu Met Leu Pro Glu Glu Val Glu Glu Val 
            20                  25                  30          


Ile Gly Asn Lys Pro Glu Ser Asp Ile Leu Val His Thr Ala Tyr Asp 
        35                  40                  45              


Glu Ser Thr Asp Glu Asn Val Met Leu Leu Thr Ser Asp Ala Pro Glu 
    50                  55                  60                  


Tyr Lys Pro Trp Ala Leu Val Ile Gln Asp Ser Asn Gly Glu Asn Lys 
65                  70                  75                  80  


Ile Lys Met Leu Ser Gly Gly Ser Lys Arg Thr Ala Asp Gly Ser Glu 
                85                  90                  95      


Phe Glu Ser Pro Lys Lys Lys Arg Lys Val Glu 
            100                 105         


<210>  352
<211>  1110
<212>  PRT
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  352

Met Val Pro Lys Lys Lys Arg Lys Val Ala Ala Phe Lys Pro Asn Pro 
1               5                   10                  15      


Ile Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Ala Ser Val Gly Trp 
            20                  25                  30          


Ala Met Val Glu Ile Asp Glu Glu Glu Asn Pro Ile Arg Leu Ile Asp 
        35                  40                  45              


Leu Gly Val Arg Val Phe Glu Arg Ala Glu Val Pro Lys Thr Gly Asp 
    50                  55                  60                  


Ser Leu Ala Met Ala Arg Arg Leu Ala Arg Ser Val Arg Arg Leu Thr 
65                  70                  75                  80  


Arg Arg Arg Ala His Arg Leu Leu Arg Ala Arg Arg Leu Leu Lys Arg 
                85                  90                  95      


Glu Gly Val Leu Gln Ala Ala Asp Phe Asp Glu Asn Gly Leu Ile Lys 
            100                 105                 110         


Ser Leu Pro Asn Thr Pro Trp Gln Leu Arg Ala Ala Ala Leu Asp Arg 
        115                 120                 125             


Lys Leu Thr Pro Leu Glu Trp Ser Ala Val Leu Leu His Leu Ile Lys 
    130                 135                 140                 


His Arg Gly Tyr Leu Ser Gln Arg Lys Asn Glu Gly Glu Thr Ala Asp 
145                 150                 155                 160 


Lys Glu Leu Gly Ala Leu Leu Lys Gly Val Ala Asn Asn Ala His Ala 
                165                 170                 175     


Leu Gln Thr Gly Asp Phe Arg Thr Pro Ala Glu Leu Ala Leu Asn Lys 
            180                 185                 190         


Phe Glu Lys Glu Ser Gly His Ile Arg Asn Gln Arg Gly Asp Tyr Ser 
        195                 200                 205             


His Thr Phe Ser Arg Lys Asp Leu Gln Ala Glu Leu Ile Leu Leu Phe 
    210                 215                 220                 


Glu Lys Gln Lys Glu Phe Gly Asn Pro His Val Ser Gly Gly Leu Lys 
225                 230                 235                 240 


Glu Gly Ile Glu Thr Leu Leu Met Thr Gln Arg Pro Ala Leu Ser Gly 
                245                 250                 255     


Asp Ala Val Gln Lys Met Leu Gly His Cys Thr Phe Glu Pro Ala Glu 
            260                 265                 270         


Pro Lys Ala Ala Lys Asn Thr Tyr Thr Ala Glu Arg Phe Ile Trp Leu 
        275                 280                 285             


Thr Lys Leu Asn Asn Leu Arg Ile Leu Glu Gln Gly Ser Glu Arg Pro 
    290                 295                 300                 


Leu Thr Asp Thr Glu Arg Ala Thr Leu Met Asp Glu Pro Tyr Arg Lys 
305                 310                 315                 320 


Ser Lys Leu Thr Tyr Ala Gln Ala Arg Lys Leu Leu Gly Leu Glu Asp 
                325                 330                 335     


Thr Ala Phe Phe Lys Gly Leu Arg Tyr Gly Lys Asp Asn Ala Glu Ala 
            340                 345                 350         


Ser Thr Leu Met Glu Met Lys Ala Tyr His Ala Ile Ser Arg Ala Leu 
        355                 360                 365             


Glu Lys Glu Gly Leu Lys Asp Lys Lys Ser Pro Leu Asn Leu Ser Ser 
    370                 375                 380                 


Glu Leu Gln Asp Glu Ile Gly Thr Ala Phe Ser Leu Phe Lys Thr Asp 
385                 390                 395                 400 


Glu Asp Ile Thr Gly Arg Leu Lys Asp Arg Val Gln Pro Glu Ile Leu 
                405                 410                 415     


Glu Ala Leu Leu Lys His Ile Ser Phe Asp Lys Phe Val Gln Ile Ser 
            420                 425                 430         


Leu Lys Ala Leu Arg Arg Ile Val Pro Leu Met Glu Gln Gly Lys Arg 
        435                 440                 445             


Tyr Asp Glu Ala Cys Ala Glu Ile Tyr Gly Asp His Tyr Gly Lys Lys 
    450                 455                 460                 


Asn Thr Glu Glu Lys Ile Tyr Leu Pro Pro Ile Pro Ala Asp Glu Ile 
465                 470                 475                 480 


Arg Asn Pro Val Val Leu Arg Ala Leu Ser Gln Ala Arg Lys Val Ile 
                485                 490                 495     


Asn Gly Val Val Arg Arg Tyr Gly Ser Pro Ala Arg Ile His Ile Glu 
            500                 505                 510         


Thr Ala Arg Glu Val Gly Lys Ser Phe Lys Asp Arg Lys Glu Ile Glu 
        515                 520                 525             


Lys Arg Gln Glu Glu Asn Arg Lys Asp Arg Glu Lys Ala Ala Ala Lys 
    530                 535                 540                 


Phe Arg Glu Tyr Phe Pro Asn Phe Val Gly Glu Pro Lys Ser Lys Asp 
545                 550                 555                 560 


Ile Leu Lys Leu Arg Leu Tyr Glu Gln Gln His Gly Lys Cys Leu Tyr 
                565                 570                 575     


Ser Gly Lys Glu Ile Asn Leu Val Arg Leu Asn Glu Lys Gly Tyr Val 
            580                 585                 590         


Glu Ile Asp His Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp Ser Phe 
        595                 600                 605             


Asn Asn Lys Val Leu Val Leu Gly Ser Glu Asn Gln Asn Lys Gly Asn 
    610                 615                 620                 


Gln Thr Pro Tyr Glu Tyr Phe Asn Gly Lys Asp Asn Ser Arg Glu Trp 
625                 630                 635                 640 


Gln Glu Phe Lys Ala Arg Val Glu Thr Ser Arg Phe Pro Arg Ser Lys 
                645                 650                 655     


Lys Gln Arg Ile Leu Leu Gln Lys Phe Asp Glu Asp Gly Phe Lys Glu 
            660                 665                 670         


Cys Asn Leu Asn Asp Thr Arg Tyr Val Asn Arg Phe Leu Cys Gln Phe 
        675                 680                 685             


Val Ala Asp His Ile Leu Leu Thr Gly Lys Gly Lys Arg Arg Val Phe 
    690                 695                 700                 


Ala Ser Asn Gly Gln Ile Thr Asn Leu Leu Arg Gly Phe Trp Gly Leu 
705                 710                 715                 720 


Arg Lys Val Arg Ala Glu Asn Asp Arg His His Ala Leu Asp Ala Val 
                725                 730                 735     


Val Val Ala Cys Ser Thr Val Ala Met Gln Gln Lys Ile Thr Arg Phe 
            740                 745                 750         


Val Arg Tyr Lys Glu Met Asn Ala Phe Asp Gly Lys Thr Ile Asp Lys 
        755                 760                 765             


Glu Thr Gly Lys Val Leu His Gln Lys Thr His Phe Pro Gln Pro Trp 
    770                 775                 780                 


Glu Phe Phe Ala Gln Glu Val Met Ile Arg Val Phe Gly Lys Pro Asp 
785                 790                 795                 800 


Gly Lys Pro Glu Phe Glu Glu Ala Asp Thr Pro Glu Lys Leu Arg Thr 
                805                 810                 815     


Leu Leu Ala Glu Lys Leu Ser Ser Arg Pro Glu Ala Val His Glu Tyr 
            820                 825                 830         


Val Thr Pro Leu Phe Val Ser Arg Ala Pro Asn Arg Lys Met Ser Gly 
        835                 840                 845             


Ala His Lys Asp Thr Leu Arg Ser Ala Lys Arg Phe Val Lys His Asn 
    850                 855                 860                 


Glu Lys Ile Ser Val Lys Arg Val Trp Leu Thr Glu Ile Lys Leu Ala 
865                 870                 875                 880 


Asp Leu Glu Asn Met Val Asn Tyr Lys Asn Gly Arg Glu Ile Glu Leu 
                885                 890                 895     


Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala Tyr Gly Gly Asn Ala Lys 
            900                 905                 910         


Gln Ala Phe Asp Pro Lys Asp Asn Pro Phe Tyr Lys Lys Gly Gly Gln 
        915                 920                 925             


Leu Val Lys Ala Val Arg Val Glu Lys Thr Gln Glu Ser Gly Val Leu 
    930                 935                 940                 


Leu Asn Lys Lys Asn Ala Tyr Thr Ile Ala Asp Asn Gly Asp Met Val 
945                 950                 955                 960 


Arg Val Asp Val Phe Cys Lys Val Asp Lys Lys Gly Lys Asn Gln Tyr 
                965                 970                 975     


Phe Ile Val Pro Ile Tyr Ala Trp Gln Val Ala Glu Asn Ile Leu Pro 
            980                 985                 990         


Asp Ile Asp Cys Lys Gly Tyr Arg  Ile Asp Asp Ser Tyr  Thr Phe Cys 
        995                 1000                 1005             


Phe Ser  Leu His Lys Tyr Asp  Leu Ile Ala Phe Gln  Lys Asp Glu 
    1010                 1015                 1020             


Lys Ser  Lys Val Glu Phe Ala  Tyr Tyr Ile Asn Cys  Asp Ser Ser 
    1025                 1030                 1035             


Asn Gly  Arg Phe Tyr Leu Ala  Trp His Asp Lys Gly  Ser Lys Glu 
    1040                 1045                 1050             


Gln Gln  Phe Arg Ile Ser Thr  Gln Asn Leu Val Leu  Ile Gln Lys 
    1055                 1060                 1065             


Tyr Gln  Val Asn Glu Leu Gly  Lys Glu Ile Arg Pro  Cys Arg Leu 
    1070                 1075                 1080             


Lys Lys  Arg Pro Pro Val Arg  Tyr Pro Tyr Asp Val  Pro Asp Tyr 
    1085                 1090                 1095             


Ala Ala  Ala Pro Ala Ala Lys  Lys Lys Lys Leu Asp  
    1100                 1105                 1110 


<210>  353
<211>  1082
<212>  PRT
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  353

Met Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Glu 
            20                  25                  30          


Glu Asn Pro Ile Arg Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asn Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Ile Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Ser Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Val Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Val 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Cys Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp His Ile Leu Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Arg Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Lys Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Ala His Lys Asp Thr Leu Arg Ser 
        835                 840                 845             


Ala Lys Arg Phe Val Lys His Asn Glu Lys Ile Ser Val Lys Arg Val 
    850                 855                 860                 


Trp Leu Thr Glu Ile Lys Leu Ala Asp Leu Glu Asn Met Val Asn Tyr 
865                 870                 875                 880 


Lys Asn Gly Arg Glu Ile Glu Leu Tyr Glu Ala Leu Lys Ala Arg Leu 
                885                 890                 895     


Glu Ala Tyr Gly Gly Asn Ala Lys Gln Ala Phe Asp Pro Lys Asp Asn 
            900                 905                 910         


Pro Phe Tyr Lys Lys Gly Gly Gln Leu Val Lys Ala Val Arg Val Glu 
        915                 920                 925             


Lys Thr Gln Glu Ser Gly Val Leu Leu Asn Lys Lys Asn Ala Tyr Thr 
    930                 935                 940                 


Ile Ala Asp Asn Gly Asp Met Val Arg Val Asp Val Phe Cys Lys Val 
945                 950                 955                 960 


Asp Lys Lys Gly Lys Asn Gln Tyr Phe Ile Val Pro Ile Tyr Ala Trp 
                965                 970                 975     


Gln Val Ala Glu Asn Ile Leu Pro Asp Ile Asp Cys Lys Gly Tyr Arg 
            980                 985                 990         


Ile Asp Asp Ser Tyr Thr Phe Cys  Phe Ser Leu His Lys  Tyr Asp Leu 
        995                 1000                 1005             


Ile Ala  Phe Gln Lys Asp Glu  Lys Ser Lys Val Glu  Phe Ala Tyr 
    1010                 1015                 1020             


Tyr Ile  Asn Cys Asp Ser Ser  Asn Gly Arg Phe Tyr  Leu Ala Trp 
    1025                 1030                 1035             


His Asp  Lys Gly Ser Lys Glu  Gln Gln Phe Arg Ile  Ser Thr Gln 
    1040                 1045                 1050             


Asn Leu  Val Leu Ile Gln Lys  Tyr Gln Val Asn Glu  Leu Gly Lys 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg 
    1070                 1075                 1080         


<210>  354
<211>  1121
<212>  PRT
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  354

Met Asp Gly Ser Gly Gly Gly Ser Pro Lys Lys Lys Arg Lys Val Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile 
            20                  25                  30          


Leu Gly Leu Asp Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu 
        35                  40                  45              


Ile Asp Glu Glu Glu Asn Pro Ile Arg Leu Ile Asp Leu Gly Val Arg 
    50                  55                  60                  


Val Phe Glu Arg Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met 
65                  70                  75                  80  


Ala Arg Arg Leu Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala 
                85                  90                  95      


His Arg Leu Leu Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu 
            100                 105                 110         


Gln Ala Ala Asp Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn 
        115                 120                 125             


Thr Pro Trp Gln Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro 
    130                 135                 140                 


Leu Glu Trp Ser Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr 
145                 150                 155                 160 


Leu Ser Gln Arg Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly 
                165                 170                 175     


Ala Leu Leu Lys Gly Val Ala Asn Asn Ala His Ala Leu Gln Thr Gly 
            180                 185                 190         


Asp Phe Arg Thr Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu 
        195                 200                 205             


Ser Gly His Ile Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser 
    210                 215                 220                 


Arg Lys Asp Leu Gln Ala Glu Leu Ile Leu Leu Phe Glu Lys Gln Lys 
225                 230                 235                 240 


Glu Phe Gly Asn Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu 
                245                 250                 255     


Thr Leu Leu Met Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln 
            260                 265                 270         


Lys Met Leu Gly His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala 
        275                 280                 285             


Lys Asn Thr Tyr Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn 
    290                 295                 300                 


Asn Leu Arg Ile Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr 
305                 310                 315                 320 


Glu Arg Ala Thr Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr 
                325                 330                 335     


Tyr Ala Gln Ala Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe 
            340                 345                 350         


Lys Gly Leu Arg Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met 
        355                 360                 365             


Glu Met Lys Ala Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly 
    370                 375                 380                 


Leu Lys Asp Lys Lys Ser Pro Leu Asn Leu Ser Ser Glu Leu Gln Asp 
385                 390                 395                 400 


Glu Ile Gly Thr Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr 
                405                 410                 415     


Gly Arg Leu Lys Asp Arg Val Gln Pro Glu Ile Leu Glu Ala Leu Leu 
            420                 425                 430         


Lys His Ile Ser Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu 
        435                 440                 445             


Arg Arg Ile Val Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala 
    450                 455                 460                 


Cys Ala Glu Ile Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu 
465                 470                 475                 480 


Lys Ile Tyr Leu Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val 
                485                 490                 495     


Val Leu Arg Ala Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val 
            500                 505                 510         


Arg Arg Tyr Gly Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu 
        515                 520                 525             


Val Gly Lys Ser Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu 
    530                 535                 540                 


Glu Asn Arg Lys Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr 
545                 550                 555                 560 


Phe Pro Asn Phe Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu 
                565                 570                 575     


Arg Leu Tyr Glu Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu 
            580                 585                 590         


Ile Asn Leu Val Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His 
        595                 600                 605             


Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val 
    610                 615                 620                 


Leu Val Leu Gly Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr 
625                 630                 635                 640 


Glu Tyr Phe Asn Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys 
                645                 650                 655     


Ala Arg Val Glu Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile 
            660                 665                 670         


Leu Leu Gln Lys Phe Asp Glu Asp Gly Phe Lys Glu Cys Asn Leu Asn 
        675                 680                 685             


Asp Thr Arg Tyr Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp His 
    690                 695                 700                 


Ile Leu Leu Thr Gly Lys Gly Lys Arg Arg Val Phe Ala Ser Asn Gly 
705                 710                 715                 720 


Gln Ile Thr Asn Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg 
                725                 730                 735     


Ala Glu Asn Asp Arg His His Ala Leu Asp Ala Val Val Val Ala Cys 
            740                 745                 750         


Ser Thr Val Ala Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys 
        755                 760                 765             


Glu Met Asn Ala Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Lys 
    770                 775                 780                 


Val Leu His Gln Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala 
785                 790                 795                 800 


Gln Glu Val Met Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu 
                805                 810                 815     


Phe Glu Glu Ala Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu 
            820                 825                 830         


Lys Leu Ser Ser Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu 
        835                 840                 845             


Phe Val Ser Arg Ala Pro Asn Arg Lys Met Ser Gly Ala His Lys Asp 
    850                 855                 860                 


Thr Leu Arg Ser Ala Lys Arg Phe Val Lys His Asn Glu Lys Ile Ser 
865                 870                 875                 880 


Val Lys Arg Val Trp Leu Thr Glu Ile Lys Leu Ala Asp Leu Glu Asn 
                885                 890                 895     


Met Val Asn Tyr Lys Asn Gly Arg Glu Ile Glu Leu Tyr Glu Ala Leu 
            900                 905                 910         


Lys Ala Arg Leu Glu Ala Tyr Gly Gly Asn Ala Lys Gln Ala Phe Asp 
        915                 920                 925             


Pro Lys Asp Asn Pro Phe Tyr Lys Lys Gly Gly Gln Leu Val Lys Ala 
    930                 935                 940                 


Val Arg Val Glu Lys Thr Gln Glu Ser Gly Val Leu Leu Asn Lys Lys 
945                 950                 955                 960 


Asn Ala Tyr Thr Ile Ala Asp Asn Gly Asp Met Val Arg Val Asp Val 
                965                 970                 975     


Phe Cys Lys Val Asp Lys Lys Gly Lys Asn Gln Tyr Phe Ile Val Pro 
            980                 985                 990         


Ile Tyr Ala Trp Gln Val Ala Glu  Asn Ile Leu Pro Asp  Ile Asp Cys 
        995                 1000                 1005             


Lys Gly  Tyr Arg Ile Asp Asp  Ser Tyr Thr Phe Cys  Phe Ser Leu 
    1010                 1015                 1020             


His Lys  Tyr Asp Leu Ile Ala  Phe Gln Lys Asp Glu  Lys Ser Lys 
    1025                 1030                 1035             


Val Glu  Phe Ala Tyr Tyr Ile  Asn Cys Asp Ser Ser  Asn Gly Arg 
    1040                 1045                 1050             


Phe Tyr  Leu Ala Trp His Asp  Lys Gly Ser Lys Glu  Gln Gln Phe 
    1055                 1060                 1065             


Arg Ile  Ser Thr Gln Asn Leu  Val Leu Ile Gln Lys  Tyr Gln Val 
    1070                 1075                 1080             


Asn Glu  Leu Gly Lys Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg 
    1085                 1090                 1095             


Pro Pro  Val Arg Ser Glu Ser  Ala Thr Pro Glu Ser  Val Ser Gly 
    1100                 1105                 1110             


Trp Arg  Leu Phe Lys Lys Ile  Ser 
    1115                 1120     


<210>  355
<211>  1124
<212>  PRT
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  355

Met Asp Gly Ser Gly Gly Gly Ser Pro Lys Lys Lys Arg Lys Val Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile 
            20                  25                  30          


Leu Gly Leu Asp Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu 
        35                  40                  45              


Ile Asp Glu Glu Glu Asn Pro Ile Arg Leu Ile Asp Leu Gly Val Arg 
    50                  55                  60                  


Val Phe Glu Arg Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met 
65                  70                  75                  80  


Ala Arg Arg Leu Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala 
                85                  90                  95      


His Arg Leu Leu Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu 
            100                 105                 110         


Gln Ala Ala Asp Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn 
        115                 120                 125             


Thr Pro Trp Gln Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro 
    130                 135                 140                 


Leu Glu Trp Ser Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr 
145                 150                 155                 160 


Leu Ser Gln Arg Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly 
                165                 170                 175     


Ala Leu Leu Lys Gly Val Ala Asn Asn Ala His Ala Leu Gln Thr Gly 
            180                 185                 190         


Asp Phe Arg Thr Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu 
        195                 200                 205             


Ser Gly His Ile Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser 
    210                 215                 220                 


Arg Lys Asp Leu Gln Ala Glu Leu Ile Leu Leu Phe Glu Lys Gln Lys 
225                 230                 235                 240 


Glu Phe Gly Asn Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu 
                245                 250                 255     


Thr Leu Leu Met Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln 
            260                 265                 270         


Lys Met Leu Gly His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala 
        275                 280                 285             


Lys Asn Thr Tyr Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn 
    290                 295                 300                 


Asn Leu Arg Ile Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr 
305                 310                 315                 320 


Glu Arg Ala Thr Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr 
                325                 330                 335     


Tyr Ala Gln Ala Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe 
            340                 345                 350         


Lys Gly Leu Arg Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met 
        355                 360                 365             


Glu Met Lys Ala Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly 
    370                 375                 380                 


Leu Lys Asp Lys Lys Ser Pro Leu Asn Leu Ser Ser Glu Leu Gln Asp 
385                 390                 395                 400 


Glu Ile Gly Thr Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr 
                405                 410                 415     


Gly Arg Leu Lys Asp Arg Val Gln Pro Glu Ile Leu Glu Ala Leu Leu 
            420                 425                 430         


Lys His Ile Ser Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu 
        435                 440                 445             


Arg Arg Ile Val Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala 
    450                 455                 460                 


Cys Ala Glu Ile Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu 
465                 470                 475                 480 


Lys Ile Tyr Leu Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val 
                485                 490                 495     


Val Leu Arg Ala Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val 
            500                 505                 510         


Arg Arg Tyr Gly Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu 
        515                 520                 525             


Val Gly Lys Ser Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu 
    530                 535                 540                 


Glu Asn Arg Lys Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr 
545                 550                 555                 560 


Phe Pro Asn Phe Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu 
                565                 570                 575     


Arg Leu Tyr Glu Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu 
            580                 585                 590         


Ile Asn Leu Val Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His 
        595                 600                 605             


Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val 
    610                 615                 620                 


Leu Val Leu Gly Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr 
625                 630                 635                 640 


Glu Tyr Phe Asn Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys 
                645                 650                 655     


Ala Arg Val Glu Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile 
            660                 665                 670         


Leu Leu Gln Lys Phe Asp Glu Asp Gly Phe Lys Glu Cys Asn Leu Asn 
        675                 680                 685             


Asp Thr Arg Tyr Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp His 
    690                 695                 700                 


Ile Leu Leu Thr Gly Lys Gly Lys Arg Arg Val Phe Ala Ser Asn Gly 
705                 710                 715                 720 


Gln Ile Thr Asn Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg 
                725                 730                 735     


Ala Glu Asn Asp Arg His His Ala Leu Asp Ala Val Val Val Ala Cys 
            740                 745                 750         


Ser Thr Val Ala Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys 
        755                 760                 765             


Glu Met Asn Ala Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Lys 
    770                 775                 780                 


Val Leu His Gln Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala 
785                 790                 795                 800 


Gln Glu Val Met Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu 
                805                 810                 815     


Phe Glu Glu Ala Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu 
            820                 825                 830         


Lys Leu Ser Ser Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu 
        835                 840                 845             


Phe Val Ser Arg Ala Pro Asn Arg Lys Met Ser Gly Ala His Lys Asp 
    850                 855                 860                 


Thr Leu Arg Ser Ala Lys Arg Phe Val Lys His Asn Glu Lys Ile Ser 
865                 870                 875                 880 


Val Lys Arg Val Trp Leu Thr Glu Ile Lys Leu Ala Asp Leu Glu Asn 
                885                 890                 895     


Met Val Asn Tyr Lys Asn Gly Arg Glu Ile Glu Leu Tyr Glu Ala Leu 
            900                 905                 910         


Lys Ala Arg Leu Glu Ala Tyr Gly Gly Asn Ala Lys Gln Ala Phe Asp 
        915                 920                 925             


Pro Lys Asp Asn Pro Phe Tyr Lys Lys Gly Gly Gln Leu Val Lys Ala 
    930                 935                 940                 


Val Arg Val Glu Lys Thr Gln Glu Ser Gly Val Leu Leu Asn Lys Lys 
945                 950                 955                 960 


Asn Ala Tyr Thr Ile Ala Asp Asn Gly Asp Met Val Arg Val Asp Val 
                965                 970                 975     


Phe Cys Lys Val Asp Lys Lys Gly Lys Asn Gln Tyr Phe Ile Val Pro 
            980                 985                 990         


Ile Tyr Ala Trp Gln Val Ala Glu  Asn Ile Leu Pro Asp  Ile Asp Cys 
        995                 1000                 1005             


Lys Gly  Tyr Arg Ile Asp Asp  Ser Tyr Thr Phe Cys  Phe Ser Leu 
    1010                 1015                 1020             


His Lys  Tyr Asp Leu Ile Ala  Phe Gln Lys Asp Glu  Lys Ser Lys 
    1025                 1030                 1035             


Val Glu  Phe Ala Tyr Tyr Ile  Asn Cys Asp Ser Ser  Asn Gly Arg 
    1040                 1045                 1050             


Phe Tyr  Leu Ala Trp His Asp  Lys Gly Ser Lys Glu  Gln Gln Phe 
    1055                 1060                 1065             


Arg Ile  Ser Thr Gln Asn Leu  Val Leu Ile Gln Lys  Tyr Gln Val 
    1070                 1075                 1080             


Asn Glu  Leu Gly Lys Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg 
    1085                 1090                 1095             


Pro Pro  Val Arg Ser Gly Lys  Arg Thr Ala Asp Gly  Ser Gly Gly 
    1100                 1105                 1110             


Gly Ser  Pro Ala Ala Lys Lys  Lys Lys Leu Asp 
    1115                 1120                 


<210>  356
<211>  1120
<212>  PRT
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  356

Met Asp Gly Ser Gly Gly Gly Ser Pro Lys Lys Lys Arg Lys Val Glu 
1               5                   10                  15      


Asp Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys 
            20                  25                  30          


Lys Gly Gly Ser Gly Gly Gly Ala Ala Phe Lys Pro Asn Pro Ile Asn 
        35                  40                  45              


Tyr Ile Leu Gly Leu Asp Ile Gly Ile Ala Ser Val Gly Trp Ala Met 
    50                  55                  60                  


Val Glu Ile Asp Glu Glu Glu Asn Pro Ile Arg Leu Ile Asp Leu Gly 
65                  70                  75                  80  


Val Arg Val Phe Glu Arg Ala Glu Val Pro Lys Thr Gly Asp Ser Leu 
                85                  90                  95      


Ala Met Ala Arg Arg Leu Ala Arg Ser Val Arg Arg Leu Thr Arg Arg 
            100                 105                 110         


Arg Ala His Arg Leu Leu Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly 
        115                 120                 125             


Val Leu Gln Ala Ala Asp Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu 
    130                 135                 140                 


Pro Asn Thr Pro Trp Gln Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu 
145                 150                 155                 160 


Thr Pro Leu Glu Trp Ser Ala Val Leu Leu His Leu Ile Lys His Arg 
                165                 170                 175     


Gly Tyr Leu Ser Gln Arg Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu 
            180                 185                 190         


Leu Gly Ala Leu Leu Lys Gly Val Ala Asn Asn Ala His Ala Leu Gln 
        195                 200                 205             


Thr Gly Asp Phe Arg Thr Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu 
    210                 215                 220                 


Lys Glu Ser Gly His Ile Arg Asn Gln Arg Gly Asp Tyr Ser His Thr 
225                 230                 235                 240 


Phe Ser Arg Lys Asp Leu Gln Ala Glu Leu Ile Leu Leu Phe Glu Lys 
                245                 250                 255     


Gln Lys Glu Phe Gly Asn Pro His Val Ser Gly Gly Leu Lys Glu Gly 
            260                 265                 270         


Ile Glu Thr Leu Leu Met Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala 
        275                 280                 285             


Val Gln Lys Met Leu Gly His Cys Thr Phe Glu Pro Ala Glu Pro Lys 
    290                 295                 300                 


Ala Ala Lys Asn Thr Tyr Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys 
305                 310                 315                 320 


Leu Asn Asn Leu Arg Ile Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr 
                325                 330                 335     


Asp Thr Glu Arg Ala Thr Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys 
            340                 345                 350         


Leu Thr Tyr Ala Gln Ala Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala 
        355                 360                 365             


Phe Phe Lys Gly Leu Arg Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr 
    370                 375                 380                 


Leu Met Glu Met Lys Ala Tyr His Ala Ile Ser Arg Ala Leu Glu Lys 
385                 390                 395                 400 


Glu Gly Leu Lys Asp Lys Lys Ser Pro Leu Asn Leu Ser Ser Glu Leu 
                405                 410                 415     


Gln Asp Glu Ile Gly Thr Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp 
            420                 425                 430         


Ile Thr Gly Arg Leu Lys Asp Arg Val Gln Pro Glu Ile Leu Glu Ala 
        435                 440                 445             


Leu Leu Lys His Ile Ser Phe Asp Lys Phe Val Gln Ile Ser Leu Lys 
    450                 455                 460                 


Ala Leu Arg Arg Ile Val Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp 
465                 470                 475                 480 


Glu Ala Cys Ala Glu Ile Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr 
                485                 490                 495     


Glu Glu Lys Ile Tyr Leu Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn 
            500                 505                 510         


Pro Val Val Leu Arg Ala Leu Ser Gln Ala Arg Lys Val Ile Asn Gly 
        515                 520                 525             


Val Val Arg Arg Tyr Gly Ser Pro Ala Arg Ile His Ile Glu Thr Ala 
    530                 535                 540                 


Arg Glu Val Gly Lys Ser Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg 
545                 550                 555                 560 


Gln Glu Glu Asn Arg Lys Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg 
                565                 570                 575     


Glu Tyr Phe Pro Asn Phe Val Gly Glu Pro Lys Ser Lys Asp Ile Leu 
            580                 585                 590         


Lys Leu Arg Leu Tyr Glu Gln Gln His Gly Lys Cys Leu Tyr Ser Gly 
        595                 600                 605             


Lys Glu Ile Asn Leu Val Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile 
    610                 615                 620                 


Asp His Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn 
625                 630                 635                 640 


Lys Val Leu Val Leu Gly Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr 
                645                 650                 655     


Pro Tyr Glu Tyr Phe Asn Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu 
            660                 665                 670         


Phe Lys Ala Arg Val Glu Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln 
        675                 680                 685             


Arg Ile Leu Leu Gln Lys Phe Asp Glu Asp Gly Phe Lys Glu Cys Asn 
    690                 695                 700                 


Leu Asn Asp Thr Arg Tyr Val Asn Arg Phe Leu Cys Gln Phe Val Ala 
705                 710                 715                 720 


Asp His Ile Leu Leu Thr Gly Lys Gly Lys Arg Arg Val Phe Ala Ser 
                725                 730                 735     


Asn Gly Gln Ile Thr Asn Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys 
            740                 745                 750         


Val Arg Ala Glu Asn Asp Arg His His Ala Leu Asp Ala Val Val Val 
        755                 760                 765             


Ala Cys Ser Thr Val Ala Met Gln Gln Lys Ile Thr Arg Phe Val Arg 
    770                 775                 780                 


Tyr Lys Glu Met Asn Ala Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr 
785                 790                 795                 800 


Gly Lys Val Leu His Gln Lys Thr His Phe Pro Gln Pro Trp Glu Phe 
                805                 810                 815     


Phe Ala Gln Glu Val Met Ile Arg Val Phe Gly Lys Pro Asp Gly Lys 
            820                 825                 830         


Pro Glu Phe Glu Glu Ala Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu 
        835                 840                 845             


Ala Glu Lys Leu Ser Ser Arg Pro Glu Ala Val His Glu Tyr Val Thr 
    850                 855                 860                 


Pro Leu Phe Val Ser Arg Ala Pro Asn Arg Lys Met Ser Gly Ala His 
865                 870                 875                 880 


Lys Asp Thr Leu Arg Ser Ala Lys Arg Phe Val Lys His Asn Glu Lys 
                885                 890                 895     


Ile Ser Val Lys Arg Val Trp Leu Thr Glu Ile Lys Leu Ala Asp Leu 
            900                 905                 910         


Glu Asn Met Val Asn Tyr Lys Asn Gly Arg Glu Ile Glu Leu Tyr Glu 
        915                 920                 925             


Ala Leu Lys Ala Arg Leu Glu Ala Tyr Gly Gly Asn Ala Lys Gln Ala 
    930                 935                 940                 


Phe Asp Pro Lys Asp Asn Pro Phe Tyr Lys Lys Gly Gly Gln Leu Val 
945                 950                 955                 960 


Lys Ala Val Arg Val Glu Lys Thr Gln Glu Ser Gly Val Leu Leu Asn 
                965                 970                 975     


Lys Lys Asn Ala Tyr Thr Ile Ala Asp Asn Gly Asp Met Val Arg Val 
            980                 985                 990         


Asp Val Phe Cys Lys Val Asp Lys  Lys Gly Lys Asn Gln  Tyr Phe Ile 
        995                 1000                 1005             


Val Pro  Ile Tyr Ala Trp Gln  Val Ala Glu Asn Ile  Leu Pro Asp 
    1010                 1015                 1020             


Ile Asp  Cys Lys Gly Tyr Arg  Ile Asp Asp Ser Tyr  Thr Phe Cys 
    1025                 1030                 1035             


Phe Ser  Leu His Lys Tyr Asp  Leu Ile Ala Phe Gln  Lys Asp Glu 
    1040                 1045                 1050             


Lys Ser  Lys Val Glu Phe Ala  Tyr Tyr Ile Asn Cys  Asp Ser Ser 
    1055                 1060                 1065             


Asn Gly  Arg Phe Tyr Leu Ala  Trp His Asp Lys Gly  Ser Lys Glu 
    1070                 1075                 1080             


Gln Gln  Phe Arg Ile Ser Thr  Gln Asn Leu Val Leu  Ile Gln Lys 
    1085                 1090                 1095             


Tyr Gln  Val Asn Glu Leu Gly  Lys Glu Ile Arg Pro  Cys Arg Leu 
    1100                 1105                 1110             


Lys Lys  Arg Pro Pro Val Arg  
    1115                 1120 


<210>  357
<211>  1139
<212>  PRT
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  357

Met Asp Gly Ser Gly Gly Gly Ser Pro Lys Lys Lys Arg Lys Val Glu 
1               5                   10                  15      


Asp Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys 
            20                  25                  30          


Lys Gly Gly Ser Gly Gly Gly Ala Ala Phe Lys Pro Asn Pro Ile Asn 
        35                  40                  45              


Tyr Ile Leu Gly Leu Asp Ile Gly Ile Ala Ser Val Gly Trp Ala Met 
    50                  55                  60                  


Val Glu Ile Asp Glu Glu Glu Asn Pro Ile Arg Leu Ile Asp Leu Gly 
65                  70                  75                  80  


Val Arg Val Phe Glu Arg Ala Glu Val Pro Lys Thr Gly Asp Ser Leu 
                85                  90                  95      


Ala Met Ala Arg Arg Leu Ala Arg Ser Val Arg Arg Leu Thr Arg Arg 
            100                 105                 110         


Arg Ala His Arg Leu Leu Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly 
        115                 120                 125             


Val Leu Gln Ala Ala Asp Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu 
    130                 135                 140                 


Pro Asn Thr Pro Trp Gln Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu 
145                 150                 155                 160 


Thr Pro Leu Glu Trp Ser Ala Val Leu Leu His Leu Ile Lys His Arg 
                165                 170                 175     


Gly Tyr Leu Ser Gln Arg Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu 
            180                 185                 190         


Leu Gly Ala Leu Leu Lys Gly Val Ala Asn Asn Ala His Ala Leu Gln 
        195                 200                 205             


Thr Gly Asp Phe Arg Thr Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu 
    210                 215                 220                 


Lys Glu Ser Gly His Ile Arg Asn Gln Arg Gly Asp Tyr Ser His Thr 
225                 230                 235                 240 


Phe Ser Arg Lys Asp Leu Gln Ala Glu Leu Ile Leu Leu Phe Glu Lys 
                245                 250                 255     


Gln Lys Glu Phe Gly Asn Pro His Val Ser Gly Gly Leu Lys Glu Gly 
            260                 265                 270         


Ile Glu Thr Leu Leu Met Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala 
        275                 280                 285             


Val Gln Lys Met Leu Gly His Cys Thr Phe Glu Pro Ala Glu Pro Lys 
    290                 295                 300                 


Ala Ala Lys Asn Thr Tyr Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys 
305                 310                 315                 320 


Leu Asn Asn Leu Arg Ile Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr 
                325                 330                 335     


Asp Thr Glu Arg Ala Thr Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys 
            340                 345                 350         


Leu Thr Tyr Ala Gln Ala Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala 
        355                 360                 365             


Phe Phe Lys Gly Leu Arg Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr 
    370                 375                 380                 


Leu Met Glu Met Lys Ala Tyr His Ala Ile Ser Arg Ala Leu Glu Lys 
385                 390                 395                 400 


Glu Gly Leu Lys Asp Lys Lys Ser Pro Leu Asn Leu Ser Ser Glu Leu 
                405                 410                 415     


Gln Asp Glu Ile Gly Thr Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp 
            420                 425                 430         


Ile Thr Gly Arg Leu Lys Asp Arg Val Gln Pro Glu Ile Leu Glu Ala 
        435                 440                 445             


Leu Leu Lys His Ile Ser Phe Asp Lys Phe Val Gln Ile Ser Leu Lys 
    450                 455                 460                 


Ala Leu Arg Arg Ile Val Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp 
465                 470                 475                 480 


Glu Ala Cys Ala Glu Ile Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr 
                485                 490                 495     


Glu Glu Lys Ile Tyr Leu Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn 
            500                 505                 510         


Pro Val Val Leu Arg Ala Leu Ser Gln Ala Arg Lys Val Ile Asn Gly 
        515                 520                 525             


Val Val Arg Arg Tyr Gly Ser Pro Ala Arg Ile His Ile Glu Thr Ala 
    530                 535                 540                 


Arg Glu Val Gly Lys Ser Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg 
545                 550                 555                 560 


Gln Glu Glu Asn Arg Lys Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg 
                565                 570                 575     


Glu Tyr Phe Pro Asn Phe Val Gly Glu Pro Lys Ser Lys Asp Ile Leu 
            580                 585                 590         


Lys Leu Arg Leu Tyr Glu Gln Gln His Gly Lys Cys Leu Tyr Ser Gly 
        595                 600                 605             


Lys Glu Ile Asn Leu Val Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile 
    610                 615                 620                 


Asp His Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn 
625                 630                 635                 640 


Lys Val Leu Val Leu Gly Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr 
                645                 650                 655     


Pro Tyr Glu Tyr Phe Asn Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu 
            660                 665                 670         


Phe Lys Ala Arg Val Glu Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln 
        675                 680                 685             


Arg Ile Leu Leu Gln Lys Phe Asp Glu Asp Gly Phe Lys Glu Cys Asn 
    690                 695                 700                 


Leu Asn Asp Thr Arg Tyr Val Asn Arg Phe Leu Cys Gln Phe Val Ala 
705                 710                 715                 720 


Asp His Ile Leu Leu Thr Gly Lys Gly Lys Arg Arg Val Phe Ala Ser 
                725                 730                 735     


Asn Gly Gln Ile Thr Asn Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys 
            740                 745                 750         


Val Arg Ala Glu Asn Asp Arg His His Ala Leu Asp Ala Val Val Val 
        755                 760                 765             


Ala Cys Ser Thr Val Ala Met Gln Gln Lys Ile Thr Arg Phe Val Arg 
    770                 775                 780                 


Tyr Lys Glu Met Asn Ala Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr 
785                 790                 795                 800 


Gly Lys Val Leu His Gln Lys Thr His Phe Pro Gln Pro Trp Glu Phe 
                805                 810                 815     


Phe Ala Gln Glu Val Met Ile Arg Val Phe Gly Lys Pro Asp Gly Lys 
            820                 825                 830         


Pro Glu Phe Glu Glu Ala Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu 
        835                 840                 845             


Ala Glu Lys Leu Ser Ser Arg Pro Glu Ala Val His Glu Tyr Val Thr 
    850                 855                 860                 


Pro Leu Phe Val Ser Arg Ala Pro Asn Arg Lys Met Ser Gly Ala His 
865                 870                 875                 880 


Lys Asp Thr Leu Arg Ser Ala Lys Arg Phe Val Lys His Asn Glu Lys 
                885                 890                 895     


Ile Ser Val Lys Arg Val Trp Leu Thr Glu Ile Lys Leu Ala Asp Leu 
            900                 905                 910         


Glu Asn Met Val Asn Tyr Lys Asn Gly Arg Glu Ile Glu Leu Tyr Glu 
        915                 920                 925             


Ala Leu Lys Ala Arg Leu Glu Ala Tyr Gly Gly Asn Ala Lys Gln Ala 
    930                 935                 940                 


Phe Asp Pro Lys Asp Asn Pro Phe Tyr Lys Lys Gly Gly Gln Leu Val 
945                 950                 955                 960 


Lys Ala Val Arg Val Glu Lys Thr Gln Glu Ser Gly Val Leu Leu Asn 
                965                 970                 975     


Lys Lys Asn Ala Tyr Thr Ile Ala Asp Asn Gly Asp Met Val Arg Val 
            980                 985                 990         


Asp Val Phe Cys Lys Val Asp Lys  Lys Gly Lys Asn Gln  Tyr Phe Ile 
        995                 1000                 1005             


Val Pro  Ile Tyr Ala Trp Gln  Val Ala Glu Asn Ile  Leu Pro Asp 
    1010                 1015                 1020             


Ile Asp  Cys Lys Gly Tyr Arg  Ile Asp Asp Ser Tyr  Thr Phe Cys 
    1025                 1030                 1035             


Phe Ser  Leu His Lys Tyr Asp  Leu Ile Ala Phe Gln  Lys Asp Glu 
    1040                 1045                 1050             


Lys Ser  Lys Val Glu Phe Ala  Tyr Tyr Ile Asn Cys  Asp Ser Ser 
    1055                 1060                 1065             


Asn Gly  Arg Phe Tyr Leu Ala  Trp His Asp Lys Gly  Ser Lys Glu 
    1070                 1075                 1080             


Gln Gln  Phe Arg Ile Ser Thr  Gln Asn Leu Val Leu  Ile Gln Lys 
    1085                 1090                 1095             


Tyr Gln  Val Asn Glu Leu Gly  Lys Glu Ile Arg Pro  Cys Arg Leu 
    1100                 1105                 1110             


Lys Lys  Arg Pro Pro Val Arg  Ser Glu Ser Ala Thr  Pro Glu Ser 
    1115                 1120                 1125             


Val Ser  Gly Trp Arg Leu Phe  Lys Lys Ile Ser 
    1130                 1135                 


<210>  358
<211>  1113
<212>  PRT
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  358

Met Asp Gly Ser Gly Gly Gly Ser Glu Asp Lys Arg Pro Ala Ala Thr 
1               5                   10                  15      


Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys Gly Gly Ser Gly Gly Gly 
            20                  25                  30          


Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Asp Ile 
        35                  40                  45              


Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Glu Glu 
    50                  55                  60                  


Asn Pro Ile Arg Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg Ala 
65                  70                  75                  80  


Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu Ala 
                85                  90                  95      


Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu Arg 
            100                 105                 110         


Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp Phe 
        115                 120                 125             


Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln Leu 
    130                 135                 140                 


Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser Ala 
145                 150                 155                 160 


Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg Lys 
                165                 170                 175     


Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys Gly 
            180                 185                 190         


Val Ala Asn Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr Pro 
        195                 200                 205             


Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile Arg 
    210                 215                 220                 


Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu Gln 
225                 230                 235                 240 


Ala Glu Leu Ile Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn Pro 
                245                 250                 255     


His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met Thr 
            260                 265                 270         


Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly His 
        275                 280                 285             


Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr Thr 
    290                 295                 300                 


Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile Leu 
305                 310                 315                 320 


Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr Leu 
                325                 330                 335     


Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala Arg 
            340                 345                 350         


Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg Tyr 
        355                 360                 365             


Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala Tyr 
    370                 375                 380                 


His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys Lys 
385                 390                 395                 400 


Ser Pro Leu Asn Leu Ser Ser Glu Leu Gln Asp Glu Ile Gly Thr Ala 
                405                 410                 415     


Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys Asp 
            420                 425                 430         


Arg Val Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser Phe 
        435                 440                 445             


Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val Pro 
    450                 455                 460                 


Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile Tyr 
465                 470                 475                 480 


Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu Pro 
                485                 490                 495     


Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala Leu 
            500                 505                 510         


Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly Ser 
        515                 520                 525             


Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser Phe 
    530                 535                 540                 


Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys Asp 
545                 550                 555                 560 


Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe Val 
                565                 570                 575     


Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu Gln 
            580                 585                 590         


Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Val Arg 
        595                 600                 605             


Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe Ser 
    610                 615                 620                 


Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly Ser 
625                 630                 635                 640 


Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn Gly 
                645                 650                 655     


Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu Thr 
            660                 665                 670         


Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys Phe 
        675                 680                 685             


Asp Glu Asp Gly Phe Lys Glu Cys Asn Leu Asn Asp Thr Arg Tyr Val 
    690                 695                 700                 


Asn Arg Phe Leu Cys Gln Phe Val Ala Asp His Ile Leu Leu Thr Gly 
705                 710                 715                 720 


Lys Gly Lys Arg Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn Leu 
                725                 730                 735     


Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp Arg 
            740                 745                 750         


His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala Met 
        755                 760                 765             


Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala Phe 
    770                 775                 780                 


Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Lys Val Leu His Gln Lys 
785                 790                 795                 800 


Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met Ile 
                805                 810                 815     


Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala Asp 
            820                 825                 830         


Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser Arg 
        835                 840                 845             


Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg Ala 
    850                 855                 860                 


Pro Asn Arg Lys Met Ser Gly Ala His Lys Asp Thr Leu Arg Ser Ala 
865                 870                 875                 880 


Lys Arg Phe Val Lys His Asn Glu Lys Ile Ser Val Lys Arg Val Trp 
                885                 890                 895     


Leu Thr Glu Ile Lys Leu Ala Asp Leu Glu Asn Met Val Asn Tyr Lys 
            900                 905                 910         


Asn Gly Arg Glu Ile Glu Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu 
        915                 920                 925             


Ala Tyr Gly Gly Asn Ala Lys Gln Ala Phe Asp Pro Lys Asp Asn Pro 
    930                 935                 940                 


Phe Tyr Lys Lys Gly Gly Gln Leu Val Lys Ala Val Arg Val Glu Lys 
945                 950                 955                 960 


Thr Gln Glu Ser Gly Val Leu Leu Asn Lys Lys Asn Ala Tyr Thr Ile 
                965                 970                 975     


Ala Asp Asn Gly Asp Met Val Arg Val Asp Val Phe Cys Lys Val Asp 
            980                 985                 990         


Lys Lys Gly Lys Asn Gln Tyr Phe  Ile Val Pro Ile Tyr  Ala Trp Gln 
        995                 1000                 1005             


Val Ala  Glu Asn Ile Leu Pro  Asp Ile Asp Cys Lys  Gly Tyr Arg 
    1010                 1015                 1020             


Ile Asp  Asp Ser Tyr Thr Phe  Cys Phe Ser Leu His  Lys Tyr Asp 
    1025                 1030                 1035             


Leu Ile  Ala Phe Gln Lys Asp  Glu Lys Ser Lys Val  Glu Phe Ala 
    1040                 1045                 1050             


Tyr Tyr  Ile Asn Cys Asp Ser  Ser Asn Gly Arg Phe  Tyr Leu Ala 
    1055                 1060                 1065             


Trp His  Asp Lys Gly Ser Lys  Glu Gln Gln Phe Arg  Ile Ser Thr 
    1070                 1075                 1080             


Gln Asn  Leu Val Leu Ile Gln  Lys Tyr Gln Val Asn  Glu Leu Gly 
    1085                 1090                 1095             


Lys Glu  Ile Arg Pro Cys Arg  Leu Lys Lys Arg Pro  Pro Val Arg 
    1100                 1105                 1110             


<210>  359
<211>  1334
<212>  PRT
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  359

Met Asp Gly Ser Gly Gly Gly Ser Pro Lys Lys Lys Arg Lys Val Glu 
1               5                   10                  15      


Asp Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys 
            20                  25                  30          


Lys Gly Gly Ser Gly Gly Gly Glu Ala Ser Pro Ala Ser Gly Pro Arg 
        35                  40                  45              


His Leu Met Asp Pro His Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile 
    50                  55                  60                  


Gly Arg His Lys Thr Tyr Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn 
65                  70                  75                  80  


Gly Thr Ser Val Lys Met Asp Gln His Arg Gly Phe Leu His Asn Gln 
                85                  90                  95      


Ala Lys Asn Leu Leu Cys Gly Phe Tyr Gly Arg His Ala Glu Leu Arg 
            100                 105                 110         


Phe Leu Asp Leu Val Pro Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr 
        115                 120                 125             


Arg Val Thr Trp Phe Ile Ser Trp Ser Pro Cys Phe Ser Trp Gly Cys 
    130                 135                 140                 


Ala Gly Glu Val Arg Ala Phe Leu Gln Glu Asn Thr His Val Arg Leu 
145                 150                 155                 160 


Arg Ile Phe Ala Ala Arg Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys Glu 
                165                 170                 175     


Ala Leu Gln Met Leu Arg Asp Ala Gly Ala Gln Val Ser Ile Met Thr 
            180                 185                 190         


Tyr Asp Glu Phe Lys His Cys Trp Asp Thr Phe Val Asp His Gln Gly 
        195                 200                 205             


Cys Pro Phe Gln Pro Trp Asp Gly Leu Asp Glu His Ser Gln Ala Leu 
    210                 215                 220                 


Ser Gly Arg Leu Arg Ala Ile Leu Gln Asn Gln Gly Asn Ser Gly Ser 
225                 230                 235                 240 


Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ala Ala Phe 
                245                 250                 255     


Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Ala Ile Gly Ile Ala 
            260                 265                 270         


Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Glu Glu Asn Pro Ile 
        275                 280                 285             


Arg Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg Ala Glu Val Pro 
    290                 295                 300                 


Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu Ala Arg Ser Val 
305                 310                 315                 320 


Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu Arg Ala Arg Arg 
                325                 330                 335     


Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp Phe Asp Glu Asn 
            340                 345                 350         


Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln Leu Arg Ala Ala 
        355                 360                 365             


Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser Ala Val Leu Leu 
    370                 375                 380                 


His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg Lys Asn Glu Gly 
385                 390                 395                 400 


Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys Gly Val Ala Asn 
                405                 410                 415     


Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr Pro Ala Glu Leu 
            420                 425                 430         


Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile Arg Asn Gln Arg 
        435                 440                 445             


Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu Gln Ala Glu Leu 
    450                 455                 460                 


Ile Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn Pro His Val Ser 
465                 470                 475                 480 


Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met Thr Gln Arg Pro 
                485                 490                 495     


Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly His Cys Thr Phe 
            500                 505                 510         


Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr Thr Ala Glu Arg 
        515                 520                 525             


Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile Leu Glu Gln Gly 
    530                 535                 540                 


Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr Leu Met Asp Glu 
545                 550                 555                 560 


Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala Arg Lys Leu Leu 
                565                 570                 575     


Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg Tyr Gly Lys Asp 
            580                 585                 590         


Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala Tyr His Ala Ile 
        595                 600                 605             


Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys Lys Ser Pro Leu 
    610                 615                 620                 


Asn Leu Ser Ser Glu Leu Gln Asp Glu Ile Gly Thr Ala Phe Ser Leu 
625                 630                 635                 640 


Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys Asp Arg Val Gln 
                645                 650                 655     


Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser Phe Asp Lys Phe 
            660                 665                 670         


Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val Pro Leu Met Glu 
        675                 680                 685             


Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile Tyr Gly Asp His 
    690                 695                 700                 


Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu Pro Pro Ile Pro 
705                 710                 715                 720 


Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala Leu Ser Gln Ala 
                725                 730                 735     


Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly Ser Pro Ala Arg 
            740                 745                 750         


Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser Phe Lys Asp Arg 
        755                 760                 765             


Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys Asp Arg Glu Lys 
    770                 775                 780                 


Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe Val Gly Glu Pro 
785                 790                 795                 800 


Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu Gln Gln His Gly 
                805                 810                 815     


Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Val Arg Leu Asn Glu 
            820                 825                 830         


Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe Ser Arg Thr Trp 
        835                 840                 845             


Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly Ser Glu Asn Gln 
    850                 855                 860                 


Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn Gly Lys Asp Asn 
865                 870                 875                 880 


Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu Thr Ser Arg Phe 
                885                 890                 895     


Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys Phe Asp Glu Asp 
            900                 905                 910         


Gly Phe Lys Glu Cys Asn Leu Asn Asp Thr Arg Tyr Val Asn Arg Phe 
        915                 920                 925             


Leu Cys Gln Phe Val Ala Asp His Ile Leu Leu Thr Gly Lys Gly Lys 
    930                 935                 940                 


Arg Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn Leu Leu Arg Gly 
945                 950                 955                 960 


Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp Arg His His Ala 
                965                 970                 975     


Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala Met Gln Gln Lys 
            980                 985                 990         


Ile Thr Arg Phe Val Arg Tyr Lys  Glu Met Asn Ala Phe  Asp Gly Lys 
        995                 1000                 1005             


Thr Ile  Asp Lys Glu Thr Gly  Lys Val Leu His Gln  Lys Thr His 
    1010                 1015                 1020             


Phe Pro  Gln Pro Trp Glu Phe  Phe Ala Gln Glu Val  Met Ile Arg 
    1025                 1030                 1035             


Val Phe  Gly Lys Pro Asp Gly  Lys Pro Glu Phe Glu  Glu Ala Asp 
    1040                 1045                 1050             


Thr Pro  Glu Lys Leu Arg Thr  Leu Leu Ala Glu Lys  Leu Ser Ser 
    1055                 1060                 1065             


Arg Pro  Glu Ala Val His Glu  Tyr Val Thr Pro Leu  Phe Val Ser 
    1070                 1075                 1080             


Arg Ala  Pro Asn Arg Lys Met  Ser Gly Ala His Lys  Asp Thr Leu 
    1085                 1090                 1095             


Arg Ser  Ala Lys Arg Phe Val  Lys His Asn Glu Lys  Ile Ser Val 
    1100                 1105                 1110             


Lys Arg  Val Trp Leu Thr Glu  Ile Lys Leu Ala Asp  Leu Glu Asn 
    1115                 1120                 1125             


Met Val  Asn Tyr Lys Asn Gly  Arg Glu Ile Glu Leu  Tyr Glu Ala 
    1130                 1135                 1140             


Leu Lys  Ala Arg Leu Glu Ala  Tyr Gly Gly Asn Ala  Lys Gln Ala 
    1145                 1150                 1155             


Phe Asp  Pro Lys Asp Asn Pro  Phe Tyr Lys Lys Gly  Gly Gln Leu 
    1160                 1165                 1170             


Val Lys  Ala Val Arg Val Glu  Lys Thr Gln Glu Ser  Gly Val Leu 
    1175                 1180                 1185             


Leu Asn  Lys Lys Asn Ala Tyr  Thr Ile Ala Asp Asn  Gly Asp Met 
    1190                 1195                 1200             


Val Arg  Val Asp Val Phe Cys  Lys Val Asp Lys Lys  Gly Lys Asn 
    1205                 1210                 1215             


Gln Tyr  Phe Ile Val Pro Ile  Tyr Ala Trp Gln Val  Ala Glu Asn 
    1220                 1225                 1230             


Ile Leu  Pro Asp Ile Asp Cys  Lys Gly Tyr Arg Ile  Asp Asp Ser 
    1235                 1240                 1245             


Tyr Thr  Phe Cys Phe Ser Leu  His Lys Tyr Asp Leu  Ile Ala Phe 
    1250                 1255                 1260             


Gln Lys  Asp Glu Lys Ser Lys  Val Glu Phe Ala Tyr  Tyr Ile Asn 
    1265                 1270                 1275             


Cys Asp  Ser Ser Asn Gly Arg  Phe Tyr Leu Ala Trp  His Asp Lys 
    1280                 1285                 1290             


Gly Ser  Lys Glu Gln Gln Phe  Arg Ile Ser Thr Gln  Asn Leu Val 
    1295                 1300                 1305             


Leu Ile  Gln Lys Tyr Gln Val  Asn Glu Leu Gly Lys  Glu Ile Arg 
    1310                 1315                 1320             


Pro Cys  Arg Leu Lys Lys Arg  Pro Pro Val Arg 
    1325                 1330                 


<210>  360
<211>  1593
<212>  PRT
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  360

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His 
1               5                   10                  15      


Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met 
        35                  40                  45              


Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys 
    50                  55                  60                  


Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro 
65                  70                  75                  80  


Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile 
                85                  90                  95      


Ser Trp Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala 
            100                 105                 110         


Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg 
        115                 120                 125             


Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 
    130                 135                 140                 


Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His 
145                 150                 155                 160 


Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp 
                165                 170                 175     


Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala 
            180                 185                 190         


Ile Leu Gln Asn Gln Gly Asn Ser Gly Ser Glu Thr Pro Gly Thr Ser 
        195                 200                 205             


Glu Ser Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
    210                 215                 220                 


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
225                 230                 235                 240 


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
                245                 250                 255     


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
            260                 265                 270         


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
        275                 280                 285             


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
    290                 295                 300                 


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
305                 310                 315                 320 


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
                325                 330                 335     


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
            340                 345                 350         


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
        355                 360                 365             


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
    370                 375                 380                 


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
385                 390                 395                 400 


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
                405                 410                 415     


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
            420                 425                 430         


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
        435                 440                 445             


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
    450                 455                 460                 


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
465                 470                 475                 480 


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
                485                 490                 495     


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
            500                 505                 510         


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
        515                 520                 525             


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
    530                 535                 540                 


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
545                 550                 555                 560 


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
                565                 570                 575     


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
            580                 585                 590         


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
        595                 600                 605             


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
    610                 615                 620                 


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
625                 630                 635                 640 


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
                645                 650                 655     


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
            660                 665                 670         


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
        675                 680                 685             


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
    690                 695                 700                 


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
705                 710                 715                 720 


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
                725                 730                 735     


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
            740                 745                 750         


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
        755                 760                 765             


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
    770                 775                 780                 


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
785                 790                 795                 800 


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
                805                 810                 815     


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
            820                 825                 830         


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
        835                 840                 845             


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
    850                 855                 860                 


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
865                 870                 875                 880 


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
                885                 890                 895     


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
            900                 905                 910         


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
        915                 920                 925             


Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser 
    930                 935                 940                 


Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu 
945                 950                 955                 960 


Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu 
                965                 970                 975     


Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg 
            980                 985                 990         


Glu Arg Met Lys Arg Ile Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln 
        995                 1000                 1005             


Ile Leu  Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
    1010                 1015                 1020             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1025                 1030                 1035             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1040                 1045                 1050             


His Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1055                 1060                 1065             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1070                 1075                 1080             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1085                 1090                 1095             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1100                 1105                 1110             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1115                 1120                 1125             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys 
    1130                 1135                 1140             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1145                 1150                 1155             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1160                 1165                 1170             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1175                 1180                 1185             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1190                 1195                 1200             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1205                 1210                 1215             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1220                 1225                 1230             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1235                 1240                 1245             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1250                 1255                 1260             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1265                 1270                 1275             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1280                 1285                 1290             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1295                 1300                 1305             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1310                 1315                 1320             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1325                 1330                 1335             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1340                 1345                 1350             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1355                 1360                 1365             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1370                 1375                 1380             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1385                 1390                 1395             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro 
    1400                 1405                 1410             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1415                 1420                 1425             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1430                 1435                 1440             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1445                 1450                 1455             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1460                 1465                 1470             


Glu Gln  His Lys His Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser 
    1475                 1480                 1485             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1490                 1495                 1500             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1505                 1510                 1515             


Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1520                 1525                 1530             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1535                 1540                 1545             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1550                 1555                 1560             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1565                 1570                 1575             


Leu Gly  Gly Asp Gly Gly Gly  Ser Pro Lys Lys Lys  Arg Lys Val 
    1580                 1585                 1590             


<210>  361
<211>  3837
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  361
gggaagcuca gaauaaacgc ucaacuuugg ccggaucugc caccaugacc ggugccgccu       60

ucaagcccaa ccccaucaac uacauccugg gccuggacau cggcaucgcc uccgugggcu      120

gggccauggu ggagaucgac gaggaggaga accccauccg gcugaucgac cugggcgugc      180

ggguguucga gcgggccgag gugcccaaga ccggcgacuc ccuggccaug gcccggcggc      240

uggcccgguc cgugcggcgg cugacccggc ggcgggccca ccggcugcug cgggcccggc      300

ggcugcugaa gcgggagggc gugcugcagg ccgccgacuu cgacgagaac ggccugauca      360

agucccugcc caacaccccc uggcagcugc gggccgccgc ccuggaccgg aagcugaccc      420

cccuggagug guccgccgug cugcugcacc ugaucaagca ccggggcuac cugucccagc      480

ggaagaacga gggcgagacc gccgacaagg agcugggcgc ccugcugaag ggcguggcca      540

acaacgccca cgcccugcag accggcgacu uccggacccc cgccgagcug gcccugaaca      600

aguucgagaa ggaguccggc cacauccgga accagcgggg cgacuacucc cacaccuucu      660

cccggaagga ccugcaggcc gagcugaucc ugcuguucga gaagcagaag gaguucggca      720

acccccacgu guccggcggc cugaaggagg gcaucgagac ccugcugaug acccagcggc      780

ccgcccuguc cggcgacgcc gugcagaaga ugcugggcca cugcaccuuc gagcccgccg      840

agcccaaggc cgccaagaac accuacaccg ccgagcgguu caucuggcug accaagcuga      900

acaaccugcg gauccuggag cagggcuccg agcggccccu gaccgacacc gagcgggcca      960

cccugaugga cgagcccuac cggaagucca agcugaccua cgcccaggcc cggaagcugc     1020

ugggccugga ggacaccgcc uucuucaagg gccugcggua cggcaaggac aacgccgagg     1080

ccuccacccu gauggagaug aaggccuacc acgccaucuc ccgggcccug gagaaggagg     1140

gccugaagga caagaagucc ccccugaacc uguccuccga gcugcaggac gagaucggca     1200

ccgccuucuc ccuguucaag accgacgagg acaucaccgg ccggcugaag gaccgggugc     1260

agcccgagau ccuggaggcc cugcugaagc acaucuccuu cgacaaguuc gugcagaucu     1320

cccugaaggc ccugcggcgg aucgugcccc ugauggagca gggcaagcgg uacgacgagg     1380

ccugcgccga gaucuacggc gaccacuacg gcaagaagaa caccgaggag aagaucuacc     1440

ugccccccau ccccgccgac gagauccgga accccguggu gcugcgggcc cugucccagg     1500

cccggaaggu gaucaacggc guggugcggc gguacggcuc ccccgcccgg auccacaucg     1560

agaccgcccg ggaggugggc aaguccuuca aggaccggaa ggagaucgag aagcggcagg     1620

aggagaaccg gaaggaccgg gagaaggccg ccgccaaguu ccgggaguac uuccccaacu     1680

ucgugggcga gcccaagucc aaggacaucc ugaagcugcg gcuguacgag cagcagcacg     1740

gcaagugccu guacuccggc aaggagauca accuggugcg gcugaacgag aagggcuacg     1800

uggagaucga ccacgcccug cccuucuccc ggaccuggga cgacuccuuc aacaacaagg     1860

ugcuggugcu gggcuccgag aaccagaaca agggcaacca gacccccuac gaguacuuca     1920

acggcaagga caacucccgg gaguggcagg aguucaaggc ccggguggag accucccggu     1980

ucccccgguc caagaagcag cggauccugc ugcagaaguu cgacgaggac ggcuucaagg     2040

agugcaaccu gaacgacacc cgguacguga accgcuuccu gugccaguuc guggccgacc     2100

acauccugcu gaccggcaag ggcaagcggc ggguguucgc cuccaacggc cagaucacca     2160

accugcugcg gggcuucugg ggccugcgga aggugcgggc cgagaacgac cggcaccacg     2220

cccuggacgc cgugguggug gccugcucca ccguggccau gcagcagaag aucacccggu     2280

ucgugcggua caaggagaug aacgccuucg acggcaagac caucgacaag gagaccggca     2340

aggugcugca ccagaagacc cacuuccccc agcccuggga guucuucgcc caggagguga     2400

ugauccgggu guucggcaag cccgacggca agcccgaguu cgaggaggcc gacacccccg     2460

agaagcugcg gacccugcug gccgagaagc uguccucccg gcccgaggcc gugcacgagu     2520

acgugacccc ccuguucgug ucccgggccc ccaaccggaa gauguccggc gcccacaagg     2580

acacccugcg guccgccaag cgguucguga agcacaacga gaagaucucc gugaagcggg     2640

uguggcugac cgagaucaag cuggccgacc uggagaacau ggugaacuac aagaacggcc     2700

gggagaucga gcuguacgag gcccugaagg cccggcugga ggccuacggc ggcaacgcca     2760

agcaggccuu cgaccccaag gacaaccccu ucuacaagaa gggcggccag cuggugaagg     2820

ccgugcgggu ggagaagacc caggaguccg gcgugcugcu gaacaagaag aacgccuaca     2880

ccaucgccga caacggcgac auggugcggg uggacguguu cugcaaggug gacaagaagg     2940

gcaagaacca guacuucauc gugcccaucu acgccuggca gguggccgag aacauccugc     3000

ccgacaucga cugcaagggc uaccggaucg acgacuccua caccuucugc uucucccugc     3060

acaaguacga ccugaucgcc uuccagaagg acgagaaguc caagguggag uucgccuacu     3120

acaucaacug cgacuccucc aacggccggu ucuaccuggc cuggcacgac aagggcucca     3180

aggagcagca guuccggauc uccacccaga accuggugcu gauccagaag uaccagguga     3240

acgagcuggg caaggagauc cggcccugcc ggcugaagaa gcggcccccc gugcgguccg     3300

gaaagcggac cgccgacggc uccgaguucg agucccccaa gaagaagcgg aagguggagu     3360

agcuagcacc agccucaaga acacccgaau ggagucucua agcuacauaa uaccaacuua     3420

cacuuuacaa aauguugucc cccaaaaugu agccauucgu aucugcuccu aauaaaaaga     3480

aaguuucuuc acauucucuc gagaaaaaaa aaaaauggaa aaaaaaaaaa cggaaaaaaa     3540

aaaaagguaa aaaaaaaaaa uauaaaaaaa aaaaacauaa aaaaaaaaaa cgaaaaaaaa     3600

aaaacguaaa aaaaaaaaac ucaaaaaaaa aaaagauaaa aaaaaaaaac cuaaaaaaaa     3660

aaaauguaaa aaaaaaaaag ggaaaaaaaa aaaacgcaaa aaaaaaaaac acaaaaaaaa     3720

aaaaugcaaa aaaaaaaaau cgaaaaaaaa aaaaucuaaa aaaaaaaaac gaaaaaaaaa     3780

aaacccaaaa aaaaaaaaga caaaaaaaaa aaauagaaaa aaaaaaaagu uaaaaaa        3837


<210>  362
<211>  887
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  362
gggaagcuca gaauaaacgc ucaacuuugg ccggaucugc caccaugacc aaccuguccg       60

acaucaucga gaaggagacc ggcaagcagc uggugaucca ggaguccauc cugaugcugc      120

ccgaggaggu ggaggaggug aucggcaaca agcccgaguc cgacauccug gugcacaccg      180

ccuacgacga guccaccgac gagaacguga ugcugcugac cuccgacgcc cccgaguaca      240

agcccugggc ccuggugauc caggacucca acggcgagaa caagaucaag augcuguccg      300

gcggcuccaa gcggaccgcc gacggcuccg aguucgaguc ccccaagaag aagcggaagg      360

uggagugaua gcuagcacca gccucaagaa cacccgaaug gagucucuaa gcuacauaau      420

accaacuuac acuuuacaaa auguuguccc ccaaaaugua gccauucgua ucugcuccua      480

auaaaaagaa aguuucuuca cauucucucg agaaaaaaaa aaaauggaaa aaaaaaaaac      540

ggaaaaaaaa aaaagguaaa aaaaaaaaau auaaaaaaaa aaaacauaaa aaaaaaaaac      600

gaaaaaaaaa aaacguaaaa aaaaaaaacu caaaaaaaaa aaagauaaaa aaaaaaaacc      660

uaaaaaaaaa aaauguaaaa aaaaaaaagg gaaaaaaaaa aaacgcaaaa aaaaaaaaca      720

caaaaaaaaa aaaugcaaaa aaaaaaaauc gaaaaaaaaa aaaucuaaaa aaaaaaaacg      780

aaaaaaaaaa aacccaaaaa aaaaaaagac aaaaaaaaaa aauagaaaaa aaaaaaaguu      840

aaaaaaaaaa aacugaaaaa aaaaaaauuu aaaaaaaaaa aaucuag                    887


<210>  363
<211>  3889
<212>  ADN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  363
gggaagctca gaataaacgc tcaactttgg ccggatctgc caccatggtg cccaagaaga       60

agcggaaggt ggccgccttc aagcccaacc ccatcaacta catcctgggc ctggacatcg      120

gcatcgcctc cgtgggctgg gccatggtgg agatcgacga ggaggagaac cccatccggc      180

tgatcgacct gggcgtgcgg gtgttcgagc gggccgaggt gcccaagacc ggcgactccc      240

tggccatggc ccggcggctg gcccggtccg tgcggcggct gacccggcgg cgggcccacc      300

ggctgctgcg ggcccggcgg ctgctgaagc gggagggcgt gctgcaggcc gccgacttcg      360

acgagaacgg cctgatcaag tccctgccca acaccccctg gcagctgcgg gccgccgccc      420

tggaccggaa gctgaccccc ctggagtggt ccgccgtgct gctgcacctg atcaagcacc      480

ggggctacct gtcccagcgg aagaacgagg gcgagaccgc cgacaaggag ctgggcgccc      540

tgctgaaggg cgtggccaac aacgcccacg ccctgcagac cggcgacttc cggacccccg      600

ccgagctggc cctgaacaag ttcgagaagg agtccggcca catccggaac cagcggggcg      660

actactccca caccttctcc cggaaggacc tgcaggccga gctgatcctg ctgttcgaga      720

agcagaagga gttcggcaac ccccacgtgt ccggcggcct gaaggagggc atcgagaccc      780

tgctgatgac ccagcggccc gccctgtccg gcgacgccgt gcagaagatg ctgggccact      840

gcaccttcga gcccgccgag cccaaggccg ccaagaacac ctacaccgcc gagcggttca      900

tctggctgac caagctgaac aacctgcgga tcctggagca gggctccgag cggcccctga      960

ccgacaccga gcgggccacc ctgatggacg agccctaccg gaagtccaag ctgacctacg     1020

cccaggcccg gaagctgctg ggcctggagg acaccgcctt cttcaagggc ctgcggtacg     1080

gcaaggacaa cgccgaggcc tccaccctga tggagatgaa ggcctaccac gccatctccc     1140

gggccctgga gaaggagggc ctgaaggaca agaagtcccc cctgaacctg tcctccgagc     1200

tgcaggacga gatcggcacc gccttctccc tgttcaagac cgacgaggac atcaccggcc     1260

ggctgaagga ccgggtgcag cccgagatcc tggaggccct gctgaagcac atctccttcg     1320

acaagttcgt gcagatctcc ctgaaggccc tgcggcggat cgtgcccctg atggagcagg     1380

gcaagcggta cgacgaggcc tgcgccgaga tctacggcga ccactacggc aagaagaaca     1440

ccgaggagaa gatctacctg ccccccatcc ccgccgacga gatccggaac cccgtggtgc     1500

tgcgggccct gtcccaggcc cggaaggtga tcaacggcgt ggtgcggcgg tacggctccc     1560

ccgcccggat ccacatcgag accgcccggg aggtgggcaa gtccttcaag gaccggaagg     1620

agatcgagaa gcggcaggag gagaaccgga aggaccggga gaaggccgcc gccaagttcc     1680

gggagtactt ccccaacttc gtgggcgagc ccaagtccaa ggacatcctg aagctgcggc     1740

tgtacgagca gcagcacggc aagtgcctgt actccggcaa ggagatcaac ctggtgcggc     1800

tgaacgagaa gggctacgtg gagatcgacc acgccctgcc cttctcccgg acctgggacg     1860

actccttcaa caacaaggtg ctggtgctgg gctccgagaa ccagaacaag ggcaaccaga     1920

ccccctacga gtacttcaac ggcaaggaca actcccggga gtggcaggag ttcaaggccc     1980

gggtggagac ctcccggttc ccccggtcca agaagcagcg gatcctgctg cagaagttcg     2040

acgaggacgg cttcaaggag tgcaacctga acgacacccg gtacgtgaac cggttcctgt     2100

gccagttcgt ggccgaccac atcctgctga ccggcaaggg caagcggcgg gtgttcgcct     2160

ccaacggcca gatcaccaac ctgctgcggg gcttctgggg cctgcggaag gtgcgggccg     2220

agaacgaccg gcaccacgcc ctggacgccg tggtggtggc ctgctccacc gtggccatgc     2280

agcagaagat cacccggttc gtgcggtaca aggagatgaa cgccttcgac ggcaagacca     2340

tcgacaagga gaccggcaag gtgctgcacc agaagaccca cttcccccag ccctgggagt     2400

tcttcgccca ggaggtgatg atccgggtgt tcggcaagcc cgacggcaag cccgagttcg     2460

aggaggccga cacccccgag aagctgcgga ccctgctggc cgagaagctg tcctcccggc     2520

ccgaggccgt gcacgagtac gtgacccccc tgttcgtgtc ccgggccccc aaccggaaga     2580

tgtccggcgc ccacaaggac accctgcggt ccgccaagcg gttcgtgaag cacaacgaga     2640

agatctccgt gaagcgggtg tggctgaccg agatcaagct ggccgacctg gagaacatgg     2700

tgaactacaa gaacggccgg gagatcgagc tgtacgaggc cctgaaggcc cggctggagg     2760

cctacggcgg caacgccaag caggccttcg accccaagga caaccccttc tacaagaagg     2820

gcggccagct ggtgaaggcc gtgcgggtgg agaagaccca ggagtccggc gtgctgctga     2880

acaagaagaa cgcctacacc atcgccgaca acggcgacat ggtgcgggtg gacgtgttct     2940

gcaaggtgga caagaagggc aagaaccagt acttcatcgt gcccatctac gcctggcagg     3000

tggccgagaa catcctgccc gacatcgact gcaagggcta ccggatcgac gactcctaca     3060

ccttctgctt ctccctgcac aagtacgacc tgatcgcctt ccagaaggac gagaagtcca     3120

aggtggagtt cgcctactac atcaactgcg actcctccaa cggccggttc tacctggcct     3180

ggcacgacaa gggctccaag gagcagcagt tccggatctc cacccagaac ctggtgctga     3240

tccagaagta ccaggtgaac gagctgggca aggagatccg gccctgccgg ctgaagaagc     3300

ggccccccgt gcggtacccc tacgacgtgc ccgactacgc cgccgccccc gccgccaaga     3360

agaagaagct ggactagcta gcaccagcct caagaacacc cgaatggagt ctctaagcta     3420

cataatacca acttacactt tacaaaatgt tgtcccccaa aatgtagcca ttcgtatctg     3480

ctcctaataa aaagaaagtt tcttcacatt ctctcgagaa aaaaaaaaaa tggaaaaaaa     3540

aaaaacggaa aaaaaaaaaa ggtaaaaaaa aaaaatataa aaaaaaaaaa cataaaaaaa     3600

aaaaacgaaa aaaaaaaaac gtaaaaaaaa aaaactcaaa aaaaaaaaag ataaaaaaaa     3660

aaaacctaaa aaaaaaaaat gtaaaaaaaa aaaagggaaa aaaaaaaaac gcaaaaaaaa     3720

aaaacacaaa aaaaaaaaat gcaaaaaaaa aaaatcgaaa aaaaaaaaat ctaaaaaaaa     3780

aaaacgaaaa aaaaaaaacc caaaaaaaaa aaagacaaaa aaaaaaaata gaaaaaaaaa     3840

aaagttaaaa aaaaaaaact gaaaaaaaaa aaatttaaaa aaaaaaaat                 3889


<210>  364
<211>  4067
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  364
gggaagcuca gaauaaacgc ucaacuuugg ccggaucugc caccauggug cccaagaaga       60

agcggaaggu ggaggacaag cggcccgccg ccaccaagaa ggccggccag gccaagaaga      120

agaagauggc cgccuucaag cccaacccca ucaacuacau ccugggccug gacaucggca      180

ucgccuccgu gggcugggcc augguggaga ucgacgagga ggagaacccc auccggcuga      240

ucgaccuggg cgugcgggug uucgagcggg ccgaggugcc caagaccggc gacucccugg      300

ccauggcccg gcggcuggcc cgguccgugc ggcggcugac ccggcggcgg gcccaccggc      360

ugcugcgggc ccggcggcug cugaagcggg agggcgugcu gcaggccgcc gacuucgacg      420

agaacggccu gaucaagucc cugcccaaca cccccuggca gcugcgggcc gccgcccugg      480

accggaagcu gaccccccug gagugguccg ccgugcugcu gcaccugauc aagcaccggg      540

gcuaccuguc ccagcggaag aacgagggcg agaccgccga caaggagcug ggcgcccugc      600

ugaagggcgu ggccaacaac gcccacgccc ugcagaccgg cgacuuccgg acccccgccg      660

agcuggcccu gaacaaguuc gagaaggagu ccggccacau ccggaaccag cggggcgacu      720

acucccacac cuucucccgg aaggaccugc aggccgagcu gauccugcug uucgagaagc      780

agaaggaguu cggcaacccc cacguguccg gcggccugaa ggagggcauc gagacccugc      840

ugaugaccca gcggcccgcc cuguccggcg acgccgugca gaagaugcug ggccacugca      900

ccuucgagcc cgccgagccc aaggccgcca agaacaccua caccgccgag cgguucaucu      960

ggcugaccaa gcugaacaac cugcggaucc uggagcaggg cuccgagcgg ccccugaccg     1020

acaccgagcg ggccacccug auggacgagc ccuaccggaa guccaagcug accuacgccc     1080

aggcccggaa gcugcugggc cuggaggaca ccgccuucuu caagggccug cgguacggca     1140

aggacaacgc cgaggccucc acccugaugg agaugaaggc cuaccacgcc aucucccggg     1200

cccuggagaa ggagggccug aaggacaaga aguccccccu gaaccugucc uccgagcugc     1260

aggacgagau cggcaccgcc uucucccugu ucaagaccga cgaggacauc accggccggc     1320

ugaaggaccg ggugcagccc gagauccugg aggcccugcu gaagcacauc uccuucgaca     1380

aguucgugca gaucucccug aaggcccugc ggcggaucgu gccccugaug gagcagggca     1440

agcgguacga cgaggccugc gccgagaucu acggcgacca cuacggcaag aagaacaccg     1500

aggagaagau cuaccugccc cccauccccg ccgacgagau ccggaacccc guggugcugc     1560

gggcccuguc ccaggcccgg aaggugauca acggcguggu gcggcgguac ggcucccccg     1620

cccggaucca caucgagacc gcccgggagg ugggcaaguc cuucaaggac cggaaggaga     1680

ucgagaagcg gcaggaggag aaccggaagg accgggagaa ggccgccgcc aaguuccggg     1740

aguacuuccc caacuucgug ggcgagccca aguccaagga cauccugaag cugcggcugu     1800

acgagcagca gcacggcaag ugccuguacu ccggcaagga gaucaaccug gugcggcuga     1860

acgagaaggg cuacguggag aucgaccacg cccugcccuu cucccggacc ugggacgacu     1920

ccuucaacaa caaggugcug gugcugggcu ccgagaacca gaacaagggc aaccagaccc     1980

ccuacgagua cuucaacggc aaggacaacu cccgggagug gcaggaguuc aaggcccggg     2040

uggagaccuc ccgguucccc cgguccaaga agcagcggau ccugcugcag aaguucgacg     2100

aggacggcuu caaggagugc aaccugaacg acacccggua cgugaaccgg uuccugugcc     2160

aguucguggc cgaccacauc cugcugaccg gcaagggcaa gcggcgggug uucgccucca     2220

acggccagau caccaaccug cugcggggcu ucuggggccu gcggaaggug cgggccgaga     2280

acgaccggca ccacgcccug gacgccgugg ugguggccug cuccaccgug gccaugcagc     2340

agaagaucac ccgguucgug cgguacaagg agaugaacgc cuucgacggc aagaccaucg     2400

acaaggagac cggcaaggug cugcaccaga agacccacuu cccccagccc ugggaguucu     2460

ucgcccagga ggugaugauc cggguguucg gcaagcccga cggcaagccc gaguucgagg     2520

aggccgacac ccccgagaag cugcggaccc ugcuggccga gaagcugucc ucccggcccg     2580

aggccgugca cgaguacgug accccccugu ucgugucccg ggcccccaac cggaagaugu     2640

ccggcgccca caaggacacc cugcgguccg ccaagcgguu cgugaagcac aacgagaaga     2700

ucuccgugaa gcgggugugg cugaccgaga ucaagcuggc cgaccuggag aacaugguga     2760

acuacaagaa cggccgggag aucgagcugu acgaggcccu gaaggcccgg cuggaggccu     2820

acggcggcaa cgccaagcag gccuucgacc ccaaggacaa ccccuucuac aagaagggcg     2880

gccagcuggu gaaggccgug cggguggaga agacccagga guccggcgug cugcugaaca     2940

agaagaacgc cuacaccauc gccgacaacg gcgacauggu gcggguggac guguucugca     3000

agguggacaa gaagggcaag aaccaguacu ucaucgugcc caucuacgcc uggcaggugg     3060

ccgagaacau ccugcccgac aucgacugca agggcuaccg gaucgacgac uccuacaccu     3120

ucugcuucuc ccugcacaag uacgaccuga ucgccuucca gaaggacgag aaguccaagg     3180

uggaguucgc cuacuacauc aacugcgacu ccuccaacgg ccgguucuac cuggccuggc     3240

acgacaaggg cuccaaggag cagcaguucc ggaucuccac ccagaaccug gugcugaucc     3300

agaaguacca ggugaacgag cugggcaagg agauccggcc cugccggcug aagaagcggc     3360

cccccgugcg ggaggacaag cggcccgccg ccaccaagaa ggccggccag gccaagaaga     3420

agaaguaccc cuacgacgug cccgacuacg ccggcuaccc cuacgacgug cccgacuacg     3480

ccggcuccua ccccuacgac gugcccgacu acgccgccgc ccccgccgcc aagaagaaga     3540

agcuggacua gcuagcacca gccucaagaa cacccgaaug gagucucuaa gcuacauaau     3600

accaacuuac acuuuacaaa auguuguccc ccaaaaugua gccauucgua ucugcuccua     3660

auaaaaagaa aguuucuuca cauucucucg agaaaaaaaa aaaauggaaa aaaaaaaaac     3720

ggaaaaaaaa aaaagguaaa aaaaaaaaau auaaaaaaaa aaaacauaaa aaaaaaaaac     3780

gaaaaaaaaa aaacguaaaa aaaaaaaacu caaaaaaaaa aaagauaaaa aaaaaaaacc     3840

uaaaaaaaaa aaauguaaaa aaaaaaaagg gaaaaaaaaa aaacgcaaaa aaaaaaaaca     3900

caaaaaaaaa aaaugcaaaa aaaaaaaauc gaaaaaaaaa aaaucuaaaa aaaaaaaacg     3960

aaaaaaaaaa aacccaaaaa aaaaaaagac aaaaaaaaaa aauagaaaaa aaaaaaaguu     4020

aaaaaaaaaa aacugaaaaa aaaaaaauuu aaaaaaaaaa aaucuag                   4067


<210>  365
<211>  3926
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  365
gggaagcuca gaauaaacgc ucaacuuugg ccggaucugc caccauggac ggcuccggcg       60

gcggcucccc caagaagaag cggaaggugg gcggcuccgg cggcggcgcc gccuucaagc      120

ccaaccccau caacuacauc cugggccugg acaucggcau cgccuccgug ggcugggcca      180

ugguggagau cgacgaggag gagaacccca uccggcugau cgaccugggc gugcgggugu      240

ucgagcgggc cgaggugccc aagaccggcg acucccuggc cauggcccgg cggcuggccc      300

gguccgugcg gcggcugacc cggcggcggg cccaccggcu gcugcgggcc cggcggcugc      360

ugaagcggga gggcgugcug caggccgccg acuucgacga gaacggccug aucaaguccc      420

ugcccaacac ccccuggcag cugcgggccg ccgcccugga ccggaagcug accccccugg      480

agugguccgc cgugcugcug caccugauca agcaccgggg cuaccugucc cagcggaaga      540

acgagggcga gaccgccgac aaggagcugg gcgcccugcu gaagggcgug gccaacaacg      600

cccacgcccu gcagaccggc gacuuccgga cccccgccga gcuggcccug aacaaguucg      660

agaaggaguc cggccacauc cggaaccagc ggggcgacua cucccacacc uucucccgga      720

aggaccugca ggccgagcug auccugcugu ucgagaagca gaaggaguuc ggcaaccccc      780

acguguccgg cggccugaag gagggcaucg agacccugcu gaugacccag cggcccgccc      840

uguccggcga cgccgugcag aagaugcugg gccacugcac cuucgagccc gccgagccca      900

aggccgccaa gaacaccuac accgccgagc gguucaucug gcugaccaag cugaacaacc      960

ugcggauccu ggagcagggc uccgagcggc cccugaccga caccgagcgg gccacccuga     1020

uggacgagcc cuaccggaag uccaagcuga ccuacgccca ggcccggaag cugcugggcc     1080

uggaggacac cgccuucuuc aagggccugc gguacggcaa ggacaacgcc gaggccucca     1140

cccugaugga gaugaaggcc uaccacgcca ucucccgggc ccuggagaag gagggccuga     1200

aggacaagaa guccccccug aaccuguccu ccgagcugca ggacgagauc ggcaccgccu     1260

ucucccuguu caagaccgac gaggacauca ccggccggcu gaaggaccgg gugcagcccg     1320

agauccugga ggcccugcug aagcacaucu ccuucgacaa guucgugcag aucucccuga     1380

aggcccugcg gcggaucgug ccccugaugg agcagggcaa gcgguacgac gaggccugcg     1440

ccgagaucua cggcgaccac uacggcaaga agaacaccga ggagaagauc uaccugcccc     1500

ccauccccgc cgacgagauc cggaaccccg uggugcugcg ggcccugucc caggcccgga     1560

aggugaucaa cggcguggug cggcgguacg gcucccccgc ccggauccac aucgagaccg     1620

cccgggaggu gggcaagucc uucaaggacc ggaaggagau cgagaagcgg caggaggaga     1680

accggaagga ccgggagaag gccgccgcca aguuccggga guacuucccc aacuucgugg     1740

gcgagcccaa guccaaggac auccugaagc ugcggcugua cgagcagcag cacggcaagu     1800

gccuguacuc cggcaaggag aucaaccugg ugcggcugaa cgagaagggc uacguggaga     1860

ucgaccacgc ccugcccuuc ucccggaccu gggacgacuc cuucaacaac aaggugcugg     1920

ugcugggcuc cgagaaccag aacaagggca accagacccc cuacgaguac uucaacggca     1980

aggacaacuc ccgggagugg caggaguuca aggcccgggu ggagaccucc cgguuccccc     2040

gguccaagaa gcagcggauc cugcugcaga aguucgacga ggacggcuuc aaggagugca     2100

accugaacga cacccgguac gugaaccggu uccugugcca guucguggcc gaccacaucc     2160

ugcugaccgg caagggcaag cggcgggugu ucgccuccaa cggccagauc accaaccugc     2220

ugcggggcuu cuggggccug cggaaggugc gggccgagaa cgaccggcac cacgcccugg     2280

acgccguggu gguggccugc uccaccgugg ccaugcagca gaagaucacc cgguucgugc     2340

gguacaagga gaugaacgcc uucgacggca agaccaucga caaggagacc ggcaaggugc     2400

ugcaccagaa gacccacuuc ccccagcccu gggaguucuu cgcccaggag gugaugaucc     2460

ggguguucgg caagcccgac ggcaagcccg aguucgagga ggccgacacc cccgagaagc     2520

ugcggacccu gcuggccgag aagcuguccu cccggcccga ggccgugcac gaguacguga     2580

ccccccuguu cgugucccgg gcccccaacc ggaagauguc cggcgcccac aaggacaccc     2640

ugcgguccgc caagcgguuc gugaagcaca acgagaagau cuccgugaag cggguguggc     2700

ugaccgagau caagcuggcc gaccuggaga acauggugaa cuacaagaac ggccgggaga     2760

ucgagcugua cgaggcccug aaggcccggc uggaggccua cggcggcaac gccaagcagg     2820

ccuucgaccc caaggacaac cccuucuaca agaagggcgg ccagcuggug aaggccgugc     2880

ggguggagaa gacccaggag uccggcgugc ugcugaacaa gaagaacgcc uacaccaucg     2940

ccgacaacgg cgacauggug cggguggacg uguucugcaa gguggacaag aagggcaaga     3000

accaguacuu caucgugccc aucuacgccu ggcagguggc cgagaacauc cugcccgaca     3060

ucgacugcaa gggcuaccgg aucgacgacu ccuacaccuu cugcuucucc cugcacaagu     3120

acgaccugau cgccuuccag aaggacgaga aguccaaggu ggaguucgcc uacuacauca     3180

acugcgacuc cuccaacggc cgguucuacc uggccuggca cgacaagggc uccaaggagc     3240

agcaguuccg gaucuccacc cagaaccugg ugcugaucca gaaguaccag gugaacgagc     3300

ugggcaagga gauccggccc ugccggcuga agaagcggcc ccccgugcgg uccgaguccg     3360

ccacccccga guccgugucc ggcuggcggc uguucaagaa gaucuccuag cuagcaccag     3420

ccucaagaac acccgaaugg agucucuaag cuacauaaua ccaacuuaca cuuuacaaaa     3480

uguugucccc caaaauguag ccauucguau cugcuccuaa uaaaaagaaa guuucuucac     3540

auucucucga gaaaaaaaaa aaauggaaaa aaaaaaaacg gaaaaaaaaa aaagguaaaa     3600

aaaaaaaaua uaaaaaaaaa aaacauaaaa aaaaaaaacg aaaaaaaaaa aacguaaaaa     3660

aaaaaaacuc aaaaaaaaaa aagauaaaaa aaaaaaaccu aaaaaaaaaa aauguaaaaa     3720

aaaaaaaggg aaaaaaaaaa aacgcaaaaa aaaaaaacac aaaaaaaaaa aaugcaaaaa     3780

aaaaaaaucg aaaaaaaaaa aaucuaaaaa aaaaaaacga aaaaaaaaaa acccaaaaaa     3840

aaaaaagaca aaaaaaaaaa auagaaaaaa aaaaaaguua aaaaaaaaaa acugaaaaaa     3900

aaaaaauuua aaaaaaaaaa aucuag                                          3926


<210>  366
<211>  3933
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  366
gggaagcuca gaauaaacgc ucaacuuugg ccggaucugc caccauggac ggcuccggcg       60

gcggcucccc caagaagaag cggaaggugg gcggcuccgg cggcggcgcc gccuucaagc      120

ccaaccccau caacuacauc cugggccugg acaucggcau cgccuccgug ggcugggcca      180

ugguggagau cgacgaggag gagaacccca uccggcugau cgaccugggc gugcgggugu      240

ucgagcgggc cgaggugccc aagaccggcg acucccuggc cauggcccgg cggcuggccc      300

gguccgugcg gcggcugacc cggcggcggg cccaccggcu gcugcgggcc cggcggcugc      360

ugaagcggga gggcgugcug caggccgccg acuucgacga gaacggccug aucaaguccc      420

ugcccaacac ccccuggcag cugcgggccg ccgcccugga ccggaagcug accccccugg      480

agugguccgc cgugcugcug caccugauca agcaccgggg cuaccugucc cagcggaaga      540

acgagggcga gaccgccgac aaggagcugg gcgcccugcu gaagggcgug gccaacaacg      600

cccacgcccu gcagaccggc gacuuccgga cccccgccga gcuggcccug aacaaguucg      660

agaaggaguc cggccacauc cggaaccagc ggggcgacua cucccacacc uucucccgga      720

aggaccugca ggccgagcug auccugcugu ucgagaagca gaaggaguuc ggcaaccccc      780

acguguccgg cggccugaag gagggcaucg agacccugcu gaugacccag cggcccgccc      840

uguccggcga cgccgugcag aagaugcugg gccacugcac cuucgagccc gccgagccca      900

aggccgccaa gaacaccuac accgccgagc gguucaucug gcugaccaag cugaacaacc      960

ugcggauccu ggagcagggc uccgagcggc cccugaccga caccgagcgg gccacccuga     1020

uggacgagcc cuaccggaag uccaagcuga ccuacgccca ggcccggaag cugcugggcc     1080

uggaggacac cgccuucuuc aagggccugc gguacggcaa ggacaacgcc gaggccucca     1140

cccugaugga gaugaaggcc uaccacgcca ucucccgggc ccuggagaag gagggccuga     1200

aggacaagaa guccccccug aaccuguccu ccgagcugca ggacgagauc ggcaccgccu     1260

ucucccuguu caagaccgac gaggacauca ccggccggcu gaaggaccgg gugcagcccg     1320

agauccugga ggcccugcug aagcacaucu ccuucgacaa guucgugcag aucucccuga     1380

aggcccugcg gcggaucgug ccccugaugg agcagggcaa gcgguacgac gaggccugcg     1440

ccgagaucua cggcgaccac uacggcaaga agaacaccga ggagaagauc uaccugcccc     1500

ccauccccgc cgacgagauc cggaaccccg uggugcugcg ggcccugucc caggcccgga     1560

aggugaucaa cggcguggug cggcgguacg gcucccccgc ccggauccac aucgagaccg     1620

cccgggaggu gggcaagucc uucaaggacc ggaaggagau cgagaagcgg caggaggaga     1680

accggaagga ccgggagaag gccgccgcca aguuccggga guacuucccc aacuucgugg     1740

gcgagcccaa guccaaggac auccugaagc ugcggcugua cgagcagcag cacggcaagu     1800

gccuguacuc cggcaaggag aucaaccugg ugcggcugaa cgagaagggc uacguggaga     1860

ucgaccacgc ccugcccuuc ucccggaccu gggacgacuc cuucaacaac aaggugcugg     1920

ugcugggcuc cgagaaccag aacaagggca accagacccc cuacgaguac uucaacggca     1980

aggacaacuc ccgggagugg caggaguuca aggcccgggu ggagaccucc cgguuccccc     2040

gguccaagaa gcagcggauc cugcugcaga aguucgacga ggacggcuuc aaggagugca     2100

accugaacga cacccgguac gugaaccggu uccugugcca guucguggcc gaccacaucc     2160

ugcugaccgg caagggcaag cggcgggugu ucgccuccaa cggccagauc accaaccugc     2220

ugcggggcuu cuggggccug cggaaggugc gggccgagaa cgaccggcac cacgcccugg     2280

acgccguggu gguggccugc uccaccgugg ccaugcagca gaagaucacc cgguucgugc     2340

gguacaagga gaugaacgcc uucgacggca agaccaucga caaggagacc ggcaaggugc     2400

ugcaccagaa gacccacuuc ccccagcccu gggaguucuu cgcccaggag gugaugaucc     2460

ggguguucgg caagcccgac ggcaagcccg aguucgagga ggccgacacc cccgagaagc     2520

ugcggacccu gcuggccgag aagcuguccu cccggcccga ggccgugcac gaguacguga     2580

ccccccuguu cgugucccgg gcccccaacc ggaagauguc cggcgcccac aaggacaccc     2640

ugcgguccgc caagcgguuc gugaagcaca acgagaagau cuccgugaag cggguguggc     2700

ugaccgagau caagcuggcc gaccuggaga acauggugaa cuacaagaac ggccgggaga     2760

ucgagcugua cgaggcccug aaggcccggc uggaggccua cggcggcaac gccaagcagg     2820

ccuucgaccc caaggacaac cccuucuaca agaagggcgg ccagcuggug aaggccgugc     2880

ggguggagaa gacccaggag uccggcgugc ugcugaacaa gaagaacgcc uacaccaucg     2940

ccgacaacgg cgacauggug cggguggacg uguucugcaa gguggacaag aagggcaaga     3000

accaguacuu caucgugccc aucuacgccu ggcagguggc cgagaacauc cugcccgaca     3060

ucgacugcaa gggcuaccgg aucgacgacu ccuacaccuu cugcuucucc cugcacaagu     3120

acgaccugau cgccuuccag aaggacgaga aguccaaggu ggaguucgcc uacuacauca     3180

acugcgacuc cuccaacggc cgguucuacc uggccuggca cgacaagggc uccaaggagc     3240

agcaguuccg gaucuccacc cagaaccugg ugcugaucca gaaguaccag gugaacgagc     3300

ugggcaagga gauccggccc ugccggcuga agaagcggcc ccccgugcgg uccggaaagc     3360

ggaccgccga cggcuccgga ggaggaagcc ccgccgccaa gaagaagaag cuggacuagc     3420

uagcaccagc cucaagaaca cccgaaugga gucucuaagc uacauaauac caacuuacac     3480

uuuacaaaau guuguccccc aaaauguagc cauucguauc ugcuccuaau aaaaagaaag     3540

uuucuucaca uucucucgag aaaaaaaaaa aauggaaaaa aaaaaaacgg aaaaaaaaaa     3600

aagguaaaaa aaaaaaauau aaaaaaaaaa aacauaaaaa aaaaaaacga aaaaaaaaaa     3660

acguaaaaaa aaaaaacuca aaaaaaaaaa gauaaaaaaa aaaaaccuaa aaaaaaaaaa     3720

uguaaaaaaa aaaaagggaa aaaaaaaaaa cgcaaaaaaa aaaaacacaa aaaaaaaaaa     3780

ugcaaaaaaa aaaaaucgaa aaaaaaaaaa ucuaaaaaaa aaaaacgaaa aaaaaaaaac     3840

ccaaaaaaaa aaaagacaaa aaaaaaaaau agaaaaaaaa aaaguuaaaa aaaaaaaacu     3900

gaaaaaaaaa aaauuuaaaa aaaaaaaauc uag                                  3933


<210>  367
<211>  3921
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  367
gggaagcuca gaauaaacgc ucaacuuugg ccggaucugc caccauggac ggcuccggcg       60

gcggcucccc caagaagaag cggaaggugg aggacaagcg gcccgccgcc accaagaagg      120

ccggccaggc caagaagaag aagggcggcu ccggcggcgg cgccgccuuc aagcccaacc      180

ccaucaacua cauccugggc cuggacaucg gcaucgccuc cgugggcugg gccauggugg      240

agaucgacga ggaggagaac cccauccggc ugaucgaccu gggcgugcgg guguucgagc      300

gggccgaggu gcccaagacc ggcgacuccc uggccauggc ccggcggcug gcccgguccg      360

ugcggcggcu gacccggcgg cgggcccacc ggcugcugcg ggcccggcgg cugcugaagc      420

gggagggcgu gcugcaggcc gccgacuucg acgagaacgg ccugaucaag ucccugccca      480

acacccccug gcagcugcgg gccgccgccc uggaccggaa gcugaccccc cuggaguggu      540

ccgccgugcu gcugcaccug aucaagcacc ggggcuaccu gucccagcgg aagaacgagg      600

gcgagaccgc cgacaaggag cugggcgccc ugcugaaggg cguggccaac aacgcccacg      660

cccugcagac cggcgacuuc cggacccccg ccgagcuggc ccugaacaag uucgagaagg      720

aguccggcca cauccggaac cagcggggcg acuacuccca caccuucucc cggaaggacc      780

ugcaggccga gcugauccug cuguucgaga agcagaagga guucggcaac ccccacgugu      840

ccggcggccu gaaggagggc aucgagaccc ugcugaugac ccagcggccc gcccuguccg      900

gcgacgccgu gcagaagaug cugggccacu gcaccuucga gcccgccgag cccaaggccg      960

ccaagaacac cuacaccgcc gagcgguuca ucuggcugac caagcugaac aaccugcgga     1020

uccuggagca gggcuccgag cggccccuga ccgacaccga gcgggccacc cugauggacg     1080

agcccuaccg gaaguccaag cugaccuacg cccaggcccg gaagcugcug ggccuggagg     1140

acaccgccuu cuucaagggc cugcgguacg gcaaggacaa cgccgaggcc uccacccuga     1200

uggagaugaa ggccuaccac gccaucuccc gggcccugga gaaggagggc cugaaggaca     1260

agaagucccc ccugaaccug uccuccgagc ugcaggacga gaucggcacc gccuucuccc     1320

uguucaagac cgacgaggac aucaccggcc ggcugaagga ccgggugcag cccgagaucc     1380

uggaggcccu gcugaagcac aucuccuucg acaaguucgu gcagaucucc cugaaggccc     1440

ugcggcggau cgugccccug auggagcagg gcaagcggua cgacgaggcc ugcgccgaga     1500

ucuacggcga ccacuacggc aagaagaaca ccgaggagaa gaucuaccug ccccccaucc     1560

ccgccgacga gauccggaac cccguggugc ugcgggcccu gucccaggcc cggaagguga     1620

ucaacggcgu ggugcggcgg uacggcuccc ccgcccggau ccacaucgag accgcccggg     1680

aggugggcaa guccuucaag gaccggaagg agaucgagaa gcggcaggag gagaaccgga     1740

aggaccggga gaaggccgcc gccaaguucc gggaguacuu ccccaacuuc gugggcgagc     1800

ccaaguccaa ggacauccug aagcugcggc uguacgagca gcagcacggc aagugccugu     1860

acuccggcaa ggagaucaac cuggugcggc ugaacgagaa gggcuacgug gagaucgacc     1920

acgcccugcc cuucucccgg accugggacg acuccuucaa caacaaggug cuggugcugg     1980

gcuccgagaa ccagaacaag ggcaaccaga cccccuacga guacuucaac ggcaaggaca     2040

acucccggga guggcaggag uucaaggccc ggguggagac cucccgguuc ccccggucca     2100

agaagcagcg gauccugcug cagaaguucg acgaggacgg cuucaaggag ugcaaccuga     2160

acgacacccg guacgugaac cgguuccugu gccaguucgu ggccgaccac auccugcuga     2220

ccggcaaggg caagcggcgg guguucgccu ccaacggcca gaucaccaac cugcugcggg     2280

gcuucugggg ccugcggaag gugcgggccg agaacgaccg gcaccacgcc cuggacgccg     2340

uggugguggc cugcuccacc guggccaugc agcagaagau cacccgguuc gugcgguaca     2400

aggagaugaa cgccuucgac ggcaagacca ucgacaagga gaccggcaag gugcugcacc     2460

agaagaccca cuucccccag cccugggagu ucuucgccca ggaggugaug auccgggugu     2520

ucggcaagcc cgacggcaag cccgaguucg aggaggccga cacccccgag aagcugcgga     2580

cccugcuggc cgagaagcug uccucccggc ccgaggccgu gcacgaguac gugacccccc     2640

uguucguguc ccgggccccc aaccggaaga uguccggcgc ccacaaggac acccugcggu     2700

ccgccaagcg guucgugaag cacaacgaga agaucuccgu gaagcgggug uggcugaccg     2760

agaucaagcu ggccgaccug gagaacaugg ugaacuacaa gaacggccgg gagaucgagc     2820

uguacgaggc ccugaaggcc cggcuggagg ccuacggcgg caacgccaag caggccuucg     2880

accccaagga caaccccuuc uacaagaagg gcggccagcu ggugaaggcc gugcgggugg     2940

agaagaccca ggaguccggc gugcugcuga acaagaagaa cgccuacacc aucgccgaca     3000

acggcgacau ggugcgggug gacguguucu gcaaggugga caagaagggc aagaaccagu     3060

acuucaucgu gcccaucuac gccuggcagg uggccgagaa cauccugccc gacaucgacu     3120

gcaagggcua ccggaucgac gacuccuaca ccuucugcuu cucccugcac aaguacgacc     3180

ugaucgccuu ccagaaggac gagaagucca agguggaguu cgccuacuac aucaacugcg     3240

acuccuccaa cggccgguuc uaccuggccu ggcacgacaa gggcuccaag gagcagcagu     3300

uccggaucuc cacccagaac cuggugcuga uccagaagua ccaggugaac gagcugggca     3360

aggagauccg gcccugccgg cugaagaagc ggccccccgu gcgguagcua gcaccagccu     3420

caagaacacc cgaauggagu cucuaagcua cauaauacca acuuacacuu uacaaaaugu     3480

ugucccccaa aauguagcca uucguaucug cuccuaauaa aaagaaaguu ucuucacauu     3540

cucucgagaa aaaaaaaaaa uggaaaaaaa aaaaacggaa aaaaaaaaaa gguaaaaaaa     3600

aaaaauauaa aaaaaaaaaa cauaaaaaaa aaaaacgaaa aaaaaaaaac guaaaaaaaa     3660

aaaacucaaa aaaaaaaaga uaaaaaaaaa aaaccuaaaa aaaaaaaaug uaaaaaaaaa     3720

aaagggaaaa aaaaaaaacg caaaaaaaaa aaacacaaaa aaaaaaaaug caaaaaaaaa     3780

aaaucgaaaa aaaaaaaauc uaaaaaaaaa aaacgaaaaa aaaaaaaccc aaaaaaaaaa     3840

aagacaaaaa aaaaaaauag aaaaaaaaaa aguuaaaaaa aaaaaacuga aaaaaaaaaa     3900

auuuaaaaaa aaaaaaucua g                                               3921


<210>  368
<211>  3980
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  368
gggaagcuca gaauaaacgc ucaacuuugg ccggaucugc caccauggac ggcuccggcg       60

gcggcucccc caagaagaag cggaaggugg aggacaagcg gcccgccgcc accaagaagg      120

ccggccaggc caagaagaag aagggcggcu ccggcggcgg cgccgccuuc aagcccaacc      180

ccaucaacua cauccugggc cuggacaucg gcaucgccuc cgugggcugg gccauggugg      240

agaucgacga ggaggagaac cccauccggc ugaucgaccu gggcgugcgg guguucgagc      300

gggccgaggu gcccaagacc ggcgacuccc uggccauggc ccggcggcug gcccgguccg      360

ugcggcggcu gacccggcgg cgggcccacc ggcugcugcg ggcccggcgg cugcugaagc      420

gggagggcgu gcugcaggcc gccgacuucg acgagaacgg ccugaucaag ucccugccca      480

acacccccug gcagcugcgg gccgccgccc uggaccggaa gcugaccccc cuggaguggu      540

ccgccgugcu gcugcaccug aucaagcacc ggggcuaccu gucccagcgg aagaacgagg      600

gcgagaccgc cgacaaggag cugggcgccc ugcugaaggg cguggccaac aacgcccacg      660

cccugcagac cggcgacuuc cggacccccg ccgagcuggc ccugaacaag uucgagaagg      720

aguccggcca cauccggaac cagcggggcg acuacuccca caccuucucc cggaaggacc      780

ugcaggccga gcugauccug cuguucgaga agcagaagga guucggcaac ccccacgugu      840

ccggcggccu gaaggagggc aucgagaccc ugcugaugac ccagcggccc gcccuguccg      900

gcgacgccgu gcagaagaug cugggccacu gcaccuucga gcccgccgag cccaaggccg      960

ccaagaacac cuacaccgcc gagcgguuca ucuggcugac caagcugaac aaccugcgga     1020

uccuggagca gggcuccgag cggccccuga ccgacaccga gcgggccacc cugauggacg     1080

agcccuaccg gaaguccaag cugaccuacg cccaggcccg gaagcugcug ggccuggagg     1140

acaccgccuu cuucaagggc cugcgguacg gcaaggacaa cgccgaggcc uccacccuga     1200

uggagaugaa ggccuaccac gccaucuccc gggcccugga gaaggagggc cugaaggaca     1260

agaagucccc ccugaaccug uccuccgagc ugcaggacga gaucggcacc gccuucuccc     1320

uguucaagac cgacgaggac aucaccggcc ggcugaagga ccgggugcag cccgagaucc     1380

uggaggcccu gcugaagcac aucuccuucg acaaguucgu gcagaucucc cugaaggccc     1440

ugcggcggau cgugccccug auggagcagg gcaagcggua cgacgaggcc ugcgccgaga     1500

ucuacggcga ccacuacggc aagaagaaca ccgaggagaa gaucuaccug ccccccaucc     1560

ccgccgacga gauccggaac cccguggugc ugcgggcccu gucccaggcc cggaagguga     1620

ucaacggcgu ggugcggcgg uacggcuccc ccgcccggau ccacaucgag accgcccggg     1680

aggugggcaa guccuucaag gaccggaagg agaucgagaa gcggcaggag gagaaccgga     1740

aggaccggga gaaggccgcc gccaaguucc gggaguacuu ccccaacuuc gugggcgagc     1800

ccaaguccaa ggacauccug aagcugcggc uguacgagca gcagcacggc aagugccugu     1860

acuccggcaa ggagaucaac cuggugcggc ugaacgagaa gggcuacgug gagaucgacc     1920

acgcccugcc cuucucccgg accugggacg acuccuucaa caacaaggug cuggugcugg     1980

gcuccgagaa ccagaacaag ggcaaccaga cccccuacga guacuucaac ggcaaggaca     2040

acucccggga guggcaggag uucaaggccc ggguggagac cucccgguuc ccccggucca     2100

agaagcagcg gauccugcug cagaaguucg acgaggacgg cuucaaggag ugcaaccuga     2160

acgacacccg guacgugaac cgguuccugu gccaguucgu ggccgaccac auccugcuga     2220

ccggcaaggg caagcggcgg guguucgccu ccaacggcca gaucaccaac cugcugcggg     2280

gcuucugggg ccugcggaag gugcgggccg agaacgaccg gcaccacgcc cuggacgccg     2340

uggugguggc cugcuccacc guggccaugc agcagaagau cacccgguuc gugcgguaca     2400

aggagaugaa cgccuucgac ggcaagacca ucgacaagga gaccggcaag gugcugcacc     2460

agaagaccca cuucccccag cccugggagu ucuucgccca ggaggugaug auccgggugu     2520

ucggcaagcc cgacggcaag cccgaguucg aggaggccga cacccccgag aagcugcgga     2580

cccugcuggc cgagaagcug uccucccggc ccgaggccgu gcacgaguac gugacccccc     2640

uguucguguc ccgggccccc aaccggaaga uguccggcgc ccacaaggac acccugcggu     2700

ccgccaagcg guucgugaag cacaacgaga agaucuccgu gaagcgggug uggcugaccg     2760

agaucaagcu ggccgaccug gagaacaugg ugaacuacaa gaacggccgg gagaucgagc     2820

uguacgaggc ccugaaggcc cggcuggagg ccuacggcgg caacgccaag caggccuucg     2880

accccaagga caaccccuuc uacaagaagg gcggccagcu ggugaaggcc gugcgggugg     2940

agaagaccca ggaguccggc gugcugcuga acaagaagaa cgccuacacc aucgccgaca     3000

acggcgacau ggugcgggug gacguguucu gcaaggugga caagaagggc aagaaccagu     3060

acuucaucgu gcccaucuac gccuggcagg uggccgagaa cauccugccc gacaucgacu     3120

gcaagggcua ccggaucgac gacuccuaca ccuucugcuu cucccugcac aaguacgacc     3180

ugaucgccuu ccagaaggac gagaagucca agguggaguu cgccuacuac aucaacugcg     3240

acuccuccaa cggccgguuc uaccuggccu ggcacgacaa gggcuccaag gagcagcagu     3300

uccggaucuc cacccagaac cuggugcuga uccagaagua ccaggugaac gagcugggca     3360

aggagauccg gcccugccgg cugaagaagc ggccccccgu gcgguccgag uccgccaccc     3420

ccgaguccgu guccggcugg cggcuguuca agaagaucuc cuagcuagca ccagccucaa     3480

gaacacccga auggagucuc uaagcuacau aauaccaacu uacacuuuac aaaauguugu     3540

cccccaaaau guagccauuc guaucugcuc cuaauaaaaa gaaaguuucu ucacauucuc     3600

ucgagaaaaa aaaaaaaugg aaaaaaaaaa aacggaaaaa aaaaaaaggu aaaaaaaaaa     3660

aauauaaaaa aaaaaaacau aaaaaaaaaa aacgaaaaaa aaaaaacgua aaaaaaaaaa     3720

acucaaaaaa aaaaaagaua aaaaaaaaaa accuaaaaaa aaaaaaugua aaaaaaaaaa     3780

agggaaaaaa aaaaaacgca aaaaaaaaaa acacaaaaaa aaaaaaugca aaaaaaaaaa     3840

aucgaaaaaa aaaaaaucua aaaaaaaaaa acgaaaaaaa aaaaacccaa aaaaaaaaaa     3900

gacaaaaaaa aaaaauagaa aaaaaaaaaa guuaaaaaaa aaaaacugaa aaaaaaaaaa     3960

uuuaaaaaaa aaaaaucuag                                                 3980


<210>  369
<211>  3867
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  369
gggaagcuca gaauaaacgc ucaacuuugg ccggaucugc caccauggac ggcuccggcg       60

gcggcucccc caagaagaag cggaaggugg gcggcuccgg cggcggcgcc gccuucaagc      120

ccaaccccau caacuacauc cugggccugg acaucggcau cgccuccgug ggcugggcca      180

ugguggagau cgacgaggag gagaacccca uccggcugau cgaccugggc gugcgggugu      240

ucgagcgggc cgaggugccc aagaccggcg acucccuggc cauggcccgg cggcuggccc      300

gguccgugcg gcggcugacc cggcggcggg cccaccggcu gcugcgggcc cggcggcugc      360

ugaagcggga gggcgugcug caggccgccg acuucgacga gaacggccug aucaaguccc      420

ugcccaacac ccccuggcag cugcgggccg ccgcccugga ccggaagcug accccccugg      480

agugguccgc cgugcugcug caccugauca agcaccgggg cuaccugucc cagcggaaga      540

acgagggcga gaccgccgac aaggagcugg gcgcccugcu gaagggcgug gccaacaacg      600

cccacgcccu gcagaccggc gacuuccgga cccccgccga gcuggcccug aacaaguucg      660

agaaggaguc cggccacauc cggaaccagc ggggcgacua cucccacacc uucucccgga      720

aggaccugca ggccgagcug auccugcugu ucgagaagca gaaggaguuc ggcaaccccc      780

acguguccgg cggccugaag gagggcaucg agacccugcu gaugacccag cggcccgccc      840

uguccggcga cgccgugcag aagaugcugg gccacugcac cuucgagccc gccgagccca      900

aggccgccaa gaacaccuac accgccgagc gguucaucug gcugaccaag cugaacaacc      960

ugcggauccu ggagcagggc uccgagcggc cccugaccga caccgagcgg gccacccuga     1020

uggacgagcc cuaccggaag uccaagcuga ccuacgccca ggcccggaag cugcugggcc     1080

uggaggacac cgccuucuuc aagggccugc gguacggcaa ggacaacgcc gaggccucca     1140

cccugaugga gaugaaggcc uaccacgcca ucucccgggc ccuggagaag gagggccuga     1200

aggacaagaa guccccccug aaccuguccu ccgagcugca ggacgagauc ggcaccgccu     1260

ucucccuguu caagaccgac gaggacauca ccggccggcu gaaggaccgg gugcagcccg     1320

agauccugga ggcccugcug aagcacaucu ccuucgacaa guucgugcag aucucccuga     1380

aggcccugcg gcggaucgug ccccugaugg agcagggcaa gcgguacgac gaggccugcg     1440

ccgagaucua cggcgaccac uacggcaaga agaacaccga ggagaagauc uaccugcccc     1500

ccauccccgc cgacgagauc cggaaccccg uggugcugcg ggcccugucc caggcccgga     1560

aggugaucaa cggcguggug cggcgguacg gcucccccgc ccggauccac aucgagaccg     1620

cccgggaggu gggcaagucc uucaaggacc ggaaggagau cgagaagcgg caggaggaga     1680

accggaagga ccgggagaag gccgccgcca aguuccggga guacuucccc aacuucgugg     1740

gcgagcccaa guccaaggac auccugaagc ugcggcugua cgagcagcag cacggcaagu     1800

gccuguacuc cggcaaggag aucaaccugg ugcggcugaa cgagaagggc uacguggaga     1860

ucgaccacgc ccugcccuuc ucccggaccu gggacgacuc cuucaacaac aaggugcugg     1920

ugcugggcuc cgagaaccag aacaagggca accagacccc cuacgaguac uucaacggca     1980

aggacaacuc ccgggagugg caggaguuca aggcccgggu ggagaccucc cgguuccccc     2040

gguccaagaa gcagcggauc cugcugcaga aguucgacga ggacggcuuc aaggagugca     2100

accugaacga cacccgguac gugaaccggu uccugugcca guucguggcc gaccacaucc     2160

ugcugaccgg caagggcaag cggcgggugu ucgccuccaa cggccagauc accaaccugc     2220

ugcggggcuu cuggggccug cggaaggugc gggccgagaa cgaccggcac cacgcccugg     2280

acgccguggu gguggccugc uccaccgugg ccaugcagca gaagaucacc cgguucgugc     2340

gguacaagga gaugaacgcc uucgacggca agaccaucga caaggagacc ggcaaggugc     2400

ugcaccagaa gacccacuuc ccccagcccu gggaguucuu cgcccaggag gugaugaucc     2460

ggguguucgg caagcccgac ggcaagcccg aguucgagga ggccgacacc cccgagaagc     2520

ugcggacccu gcuggccgag aagcuguccu cccggcccga ggccgugcac gaguacguga     2580

ccccccuguu cgugucccgg gcccccaacc ggaagauguc cggcgcccac aaggacaccc     2640

ugcgguccgc caagcgguuc gugaagcaca acgagaagau cuccgugaag cggguguggc     2700

ugaccgagau caagcuggcc gaccuggaga acauggugaa cuacaagaac ggccgggaga     2760

ucgagcugua cgaggcccug aaggcccggc uggaggccua cggcggcaac gccaagcagg     2820

ccuucgaccc caaggacaac cccuucuaca agaagggcgg ccagcuggug aaggccgugc     2880

ggguggagaa gacccaggag uccggcgugc ugcugaacaa gaagaacgcc uacaccaucg     2940

ccgacaacgg cgacauggug cggguggacg uguucugcaa gguggacaag aagggcaaga     3000

accaguacuu caucgugccc aucuacgccu ggcagguggc cgagaacauc cugcccgaca     3060

ucgacugcaa gggcuaccgg aucgacgacu ccuacaccuu cugcuucucc cugcacaagu     3120

acgaccugau cgccuuccag aaggacgaga aguccaaggu ggaguucgcc uacuacauca     3180

acugcgacuc cuccaacggc cgguucuacc uggccuggca cgacaagggc uccaaggagc     3240

agcaguuccg gaucuccacc cagaaccugg ugcugaucca gaaguaccag gugaacgagc     3300

ugggcaagga gauccggccc ugccggcuga agaagcggcc ccccgugcgg uagcuagcac     3360

cagccucaag aacacccgaa uggagucucu aagcuacaua auaccaacuu acacuuuaca     3420

aaauguuguc ccccaaaaug uagccauucg uaucugcucc uaauaaaaag aaaguuucuu     3480

cacauucucu cgagaaaaaa aaaaaaugga aaaaaaaaaa acggaaaaaa aaaaaaggua     3540

aaaaaaaaaa auauaaaaaa aaaaaacaua aaaaaaaaaa acgaaaaaaa aaaaacguaa     3600

aaaaaaaaaa cucaaaaaaa aaaagauaaa aaaaaaaaac cuaaaaaaaa aaaauguaaa     3660

aaaaaaaaag ggaaaaaaaa aaaacgcaaa aaaaaaaaac acaaaaaaaa aaaaugcaaa     3720

aaaaaaaaau cgaaaaaaaa aaaaucuaaa aaaaaaaaac gaaaaaaaaa aaacccaaaa     3780

aaaaaaaaga caaaaaaaaa aaauagaaaa aaaaaaaguu aaaaaaaaaa aacugaaaaa     3840

aaaaaaauuu aaaaaaaaaa aaucuag                                         3867


<210>  370
<211>  4563
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  370
gggaagcuca gaauaaacgc ucaacuuugg ccggaucugc caccauggac ggcuccggcg       60

gcggcucccc caagaagaag cggaaggugg aggacaagcg gcccgccgcc accaagaagg      120

ccggccaggc caagaagaag aagggcggcu ccggcggcgg cgaggccucc cccgccuccg      180

gcccccggca ccugauggac ccccacaucu ucaccuccaa cuucaacaac ggcaucggcc      240

ggcacaagac cuaccugugc uacgaggugg agcggcugga caacggcacc uccgugaaga      300

uggaccagca ccggggcuuc cugcacaacc aggccaagaa ccugcugugc ggcuucuacg      360

gccggcacgc cgagcugcgg uuccuggacc uggugcccuc ccugcagcug gaccccgccc      420

agaucuaccg ggugaccugg uucaucuccu ggucccccug cuucuccugg ggcugcgccg      480

gcgaggugcg ggccuuccug caggagaaca cccacgugcg gcugcggauc uucgccgccc      540

ggaucuacga cuacgacccc cuguacaagg aggcccugca gaugcugcgg gacgccggcg      600

cccagguguc caucaugacc uacgacgagu ucaagcacug cugggacacc uucguggacc      660

accagggcug ccccuuccag cccugggacg gccuggacga gcacucccag gcccuguccg      720

gccggcugcg ggccauccug cagaaccagg gcaacuccgg cuccgagacc cccggcaccu      780

ccgaguccgc cacccccgag uccgcagcgu ucaaaccaaa ucccaucaac uacauccugg      840

gccuggccau cggcaucgcc uccgugggcu gggccauggu ggagaucgac gaggaggaga      900

accccauccg gcugaucgac cugggcgugc ggguguucga gcgggccgag gugcccaaga      960

ccggcgacuc ccuggccaug gcccggcggc uggcccgguc cgugcggcgg cugacccggc     1020

ggcgggccca ccggcugcug cgggcccggc ggcugcugaa gcgggagggc gugcugcagg     1080

ccgccgacuu cgacgagaac ggccugauca agucccugcc caacaccccc uggcagcugc     1140

gggccgccgc ccuggaccgg aagcugaccc cccuggagug guccgccgug cugcugcacc     1200

ugaucaagca ccggggcuac cugucccagc ggaagaacga gggcgagacc gccgacaagg     1260

agcugggcgc ccugcugaag ggcguggcca acaacgccca cgcccugcag accggcgacu     1320

uccggacccc cgccgagcug gcccugaaca aguucgagaa ggaguccggc cacauccgga     1380

accagcgggg cgacuacucc cacaccuucu cccggaagga ccugcaggcc gagcugaucc     1440

ugcuguucga gaagcagaag gaguucggca acccccacgu guccggcggc cugaaggagg     1500

gcaucgagac ccugcugaug acccagcggc ccgcccuguc cggcgacgcc gugcagaaga     1560

ugcugggcca cugcaccuuc gagcccgccg agcccaaggc cgccaagaac accuacaccg     1620

ccgagcgguu caucuggcug accaagcuga acaaccugcg gauccuggag cagggcuccg     1680

agcggccccu gaccgacacc gagcgggcca cccugaugga cgagcccuac cggaagucca     1740

agcugaccua cgcccaggcc cggaagcugc ugggccugga ggacaccgcc uucuucaagg     1800

gccugcggua cggcaaggac aacgccgagg ccuccacccu gauggagaug aaggccuacc     1860

acgccaucuc ccgggcccug gagaaggagg gccugaagga caagaagucc ccccugaacc     1920

uguccuccga gcugcaggac gagaucggca ccgccuucuc ccuguucaag accgacgagg     1980

acaucaccgg ccggcugaag gaccgggugc agcccgagau ccuggaggcc cugcugaagc     2040

acaucuccuu cgacaaguuc gugcagaucu cccugaaggc ccugcggcgg aucgugcccc     2100

ugauggagca gggcaagcgg uacgacgagg ccugcgccga gaucuacggc gaccacuacg     2160

gcaagaagaa caccgaggag aagaucuacc ugccccccau ccccgccgac gagauccgga     2220

accccguggu gcugcgggcc cugucccagg cccggaaggu gaucaacggc guggugcggc     2280

gguacggcuc ccccgcccgg auccacaucg agaccgcccg ggaggugggc aaguccuuca     2340

aggaccggaa ggagaucgag aagcggcagg aggagaaccg gaaggaccgg gagaaggccg     2400

ccgccaaguu ccgggaguac uuccccaacu ucgugggcga gcccaagucc aaggacaucc     2460

ugaagcugcg gcuguacgag cagcagcacg gcaagugccu guacuccggc aaggagauca     2520

accuggugcg gcugaacgag aagggcuacg uggagaucga ccacgcccug cccuucuccc     2580

ggaccuggga cgacuccuuc aacaacaagg ugcuggugcu gggcuccgag aaccagaaca     2640

agggcaacca gacccccuac gaguacuuca acggcaagga caacucccgg gaguggcagg     2700

aguucaaggc ccggguggag accucccggu ucccccgguc caagaagcag cggauccugc     2760

ugcagaaguu cgacgaggac ggcuucaagg agugcaaccu gaacgacacc cgguacguga     2820

accgcuuccu gugccaguuc guggccgacc acauccugcu gaccggcaag ggcaagcggc     2880

ggguguucgc cuccaacggc cagaucacca accugcugcg gggcuucugg ggccugcgga     2940

aggugcgggc cgagaacgac cggcaccacg cccuggacgc cgugguggug gccugcucca     3000

ccguggccau gcagcagaag aucacccggu ucgugcggua caaggagaug aacgccuucg     3060

acggcaagac caucgacaag gagaccggca aggugcugca ccagaagacc cacuuccccc     3120

agcccuggga guucuucgcc caggagguga ugauccgggu guucggcaag cccgacggca     3180

agcccgaguu cgaggaggcc gacacccccg agaagcugcg gacccugcug gccgagaagc     3240

uguccucccg gcccgaggcc gugcacgagu acgugacccc ccuguucgug ucccgggccc     3300

ccaaccggaa gauguccggc gcccacaagg acacccugcg guccgccaag cgguucguga     3360

agcacaacga gaagaucucc gugaagcggg uguggcugac cgagaucaag cuggccgacc     3420

uggagaacau ggugaacuac aagaacggcc gggagaucga gcuguacgag gcccugaagg     3480

cccggcugga ggccuacggc ggcaacgcca agcaggccuu cgaccccaag gacaaccccu     3540

ucuacaagaa gggcggccag cuggugaagg ccgugcgggu ggagaagacc caggaguccg     3600

gcgugcugcu gaacaagaag aacgccuaca ccaucgccga caacggcgac auggugcggg     3660

uggacguguu cugcaaggug gacaagaagg gcaagaacca guacuucauc gugcccaucu     3720

acgccuggca gguggccgag aacauccugc ccgacaucga cugcaagggc uaccggaucg     3780

acgacuccua caccuucugc uucucccugc acaaguacga ccugaucgcc uuccagaagg     3840

acgagaaguc caagguggag uucgccuacu acaucaacug cgacuccucc aacggccggu     3900

ucuaccuggc cuggcacgac aagggcucca aggagcagca guuccggauc uccacccaga     3960

accuggugcu gauccagaag uaccagguga acgagcuggg caaggagauc cggcccugcc     4020

ggcugaagaa gcggcccccc gugcgguagu gacuagcacc agccucaaga acacccgaau     4080

ggagucucua agcuacauaa uaccaacuua cacuuuacaa aauguugucc cccaaaaugu     4140

agccauucgu aucugcuccu aauaaaaaga aaguuucuuc acauucucuc gagaaaaaaa     4200

aaaaauggaa aaaaaaaaaa cggaaaaaaa aaaagguaaa aaaaaaaaau auaaaaaaaa     4260

aaacauaaaa aaaaaaaacg aaaaaaaaaa aacguaaaaa aaaaaaacuc aaaaaaaaaa     4320

agauaaaaaa aaaaaaccua aaaaaaaaaa auguaaaaaa aaaaaaggga aaaaaaaaaa     4380

cgcaaaaaaa aaaaacacaa aaaaaaaaaa ugcaaaaaaa aaaaaucgaa aaaaaaaaaa     4440

ucuaaaaaaa aaaaacgaaa aaaaaaaaac ccaaaaaaaa aaaagacaaa aaaaaaaaau     4500

agaaaaaaaa aaaguuaaaa aaaaaaaacu gaaaaaaaaa aaauuuaaaa aaaaaaaauc     4560

uag                                                                   4563


<210>  371
<211>  5342
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  371
gggaagcuca gaauaaacgc ucaacuuugg ccggaucugc caccauggag gccucccccg       60

ccuccggccc ccggcaccug auggaccccc acaucuucac cuccaacuuc aacaacggca      120

ucggccggca caagaccuac cugugcuacg agguggagcg gcuggacaac ggcaccuccg      180

ugaagaugga ccagcaccgg ggcuuccugc acaaccaggc caagaaccug cugugcggcu      240

ucuacggccg gcacgccgag cugcgguucc uggaccuggu gcccucccug cagcuggacc      300

ccgcccagau cuaccgggug accugguuca ucuccugguc ccccugcuuc uccuggggcu      360

gcgccggcga ggugcgggcc uuccugcagg agaacaccca cgugcggcug cggaucuucg      420

ccgcccggau cuacgacuac gacccccugu acaaggaggc ccugcagaug cugcgggacg      480

ccggcgccca gguguccauc augaccuacg acgaguucaa gcacugcugg gacaccuucg      540

uggaccacca gggcugcccc uuccagcccu gggacggccu ggacgagcac ucccaggccc      600

uguccggccg gcugcgggcc auccugcaga accagggcaa cuccggcucc gagacccccg      660

gcaccuccga guccgccacc cccgaguccg acaagaagua cuccaucggc cuggccaucg      720

gcaccaacuc cgugggcugg gccgugauca ccgacgagua caaggugccc uccaagaagu      780

ucaaggugcu gggcaacacc gaccggcacu ccaucaagaa gaaccugauc ggcgcccugc      840

uguucgacuc cggcgagacc gccgaggcca cccggcugaa gcggaccgcc cggcggcggu      900

acacccggcg gaagaaccgg aucugcuacc ugcaggagau cuucuccaac gagauggcca      960

agguggacga cuccuucuuc caccggcugg aggaguccuu ccugguggag gaggacaaga     1020

agcacgagcg gcaccccauc uucggcaaca ucguggacga gguggccuac cacgagaagu     1080

accccaccau cuaccaccug cggaagaagc ugguggacuc caccgacaag gccgaccugc     1140

ggcugaucua ccuggcccug gcccacauga ucaaguuccg gggccacuuc cugaucgagg     1200

gcgaccugaa ccccgacaac uccgacgugg acaagcuguu cauccagcug gugcagaccu     1260

acaaccagcu guucgaggag aaccccauca acgccuccgg cguggacgcc aaggccaucc     1320

uguccgcccg gcuguccaag ucccggcggc uggagaaccu gaucgcccag cugcccggcg     1380

agaagaagaa cggccuguuc ggcaaccuga ucgcccuguc ccugggccug acccccaacu     1440

ucaaguccaa cuucgaccug gccgaggacg ccaagcugca gcuguccaag gacaccuacg     1500

acgacgaccu ggacaaccug cuggcccaga ucggcgacca guacgccgac cuguuccugg     1560

ccgccaagaa ccuguccgac gccauccugc uguccgacau ccugcgggug aacaccgaga     1620

ucaccaaggc cccccugucc gccuccauga ucaagcggua cgacgagcac caccaggacc     1680

ugacccugcu gaaggcccug gugcggcagc agcugcccga gaaguacaag gagaucuucu     1740

ucgaccaguc caagaacggc uacgccggcu acaucgacgg cggcgccucc caggaggagu     1800

ucuacaaguu caucaagccc auccuggaga agauggacgg caccgaggag cugcugguga     1860

agcugaaccg ggaggaccug cugcggaagc agcggaccuu cgacaacggc uccauccccc     1920

accagaucca ccugggcgag cugcacgcca uccugcggcg gcaggaggac uucuaccccu     1980

uccugaagga caaccgggag aagaucgaga agauccugac cuuccggauc cccuacuacg     2040

ugggcccccu ggcccggggc aacucccggu ucgccuggau gacccggaag uccgaggaga     2100

ccaucacccc cuggaacuuc gaggaggugg uggacaaggg cgccuccgcc caguccuuca     2160

ucgagcggau gaccaacuuc gacaagaacc ugcccaacga gaaggugcug cccaagcacu     2220

cccugcugua cgaguacuuc accguguaca acgagcugac caaggugaag uacgugaccg     2280

agggcaugcg gaagcccgcc uuccuguccg gcgagcagaa gaaggccauc guggaccugc     2340

uguucaagac caaccggaag gugaccguga agcagcugaa ggaggacuac uucaagaaga     2400

ucgagugcuu cgacuccgug gagaucuccg gcguggagga ccgguucaac gccucccugg     2460

gcaccuacca cgaccugcug aagaucauca aggacaagga cuuccuggac aacgaggaga     2520

acgaggacau ccuggaggac aucgugcuga cccugacccu guucgaggac cgggagauga     2580

ucgaggagcg gcugaagacc uacgcccacc uguucgacga caaggugaug aagcagcuga     2640

agcggcggcg guacaccggc uggggccggc ugucccggaa gcugaucaac ggcauccggg     2700

acaagcaguc cggcaagacc auccuggacu uccugaaguc cgacggcuuc gccaaccgga     2760

acuucaugca gcugauccac gacgacuccc ugaccuucaa ggaggacauc cagaaggccc     2820

agguguccgg ccagggcgac ucccugcacg agcacaucgc caaccuggcc ggcucccccg     2880

ccaucaagaa gggcauccug cagaccguga agguggugga cgagcuggug aaggugaugg     2940

gccggcacaa gcccgagaac aucgugaucg agauggcccg ggagaaccag accacccaga     3000

agggccagaa gaacucccgg gagcggauga agcggaucga ggagggcauc aaggagcugg     3060

gcucccagau ccugaaggag caccccgugg agaacaccca gcugcagaac gagaagcugu     3120

accuguacua ccugcagaac ggccgggaca uguacgugga ccaggagcug gacaucaacc     3180

ggcuguccga cuacgacgug gaccacaucg ugccccaguc cuuccugaag gacgacucca     3240

ucgacaacaa ggugcugacc cgguccgaca agaaccgggg caaguccgac aacgugcccu     3300

ccgaggaggu ggugaagaag augaagaacu acuggcggca gcugcugaac gccaagcuga     3360

ucacccagcg gaaguucgac aaccugacca aggccgagcg gggcggccug uccgagcugg     3420

acaaggccgg cuucaucaag cggcagcugg uggagacccg gcagaucacc aagcacgugg     3480

cccagauccu ggacucccgg augaacacca aguacgacga gaacgacaag cugauccggg     3540

aggugaaggu gaucacccug aaguccaagc ugguguccga cuuccggaag gacuuccagu     3600

ucuacaaggu gcgggagauc aacaacuacc accacgccca cgacgccuac cugaacgccg     3660

uggugggcac cgcccugauc aagaaguacc ccaagcugga guccgaguuc guguacggcg     3720

acuacaaggu guacgacgug cggaagauga ucgccaaguc cgagcaggag aucggcaagg     3780

ccaccgccaa guacuucuuc uacuccaaca ucaugaacuu cuucaagacc gagaucaccc     3840

uggccaacgg cgagauccgg aagcggcccc ugaucgagac caacggcgag accggcgaga     3900

ucguguggga caagggccgg gacuucgcca ccgugcggaa ggugcugucc augccccagg     3960

ugaacaucgu gaagaagacc gaggugcaga ccggcggcuu cuccaaggag uccauccugc     4020

ccaagcggaa cuccgacaag cugaucgccc ggaagaagga cugggacccc aagaaguacg     4080

gcggcuucga cucccccacc guggccuacu ccgugcuggu gguggccaag guggagaagg     4140

gcaaguccaa gaagcugaag uccgugaagg agcugcuggg caucaccauc auggagcggu     4200

ccuccuucga gaagaacccc aucgacuucc uggaggccaa gggcuacaag gaggugaaga     4260

aggaccugau caucaagcug cccaaguacu cccuguucga gcuggagaac ggccggaagc     4320

ggaugcuggc cuccgccggc gagcugcaga agggcaacga gcuggcccug cccuccaagu     4380

acgugaacuu ccuguaccug gccucccacu acgagaagcu gaagggcucc cccgaggaca     4440

acgagcagaa gcagcuguuc guggagcagc acaagcacua ccuggacgag aucaucgagc     4500

agaucuccga guucuccaag cgggugaucc uggccgacgc caaccuggac aaggugcugu     4560

ccgccuacaa caagcaccgg gacaagccca uccgggagca ggccgagaac aucauccacc     4620

uguucacccu gaccaaccug ggcgcccccg ccgccuucaa guacuucgac accaccaucg     4680

accggaagcg guacaccucc accaaggagg ugcuggacgc cacccugauc caccagucca     4740

ucaccggccu guacgagacc cggaucgacc ugucccagcu gggcggcgac ggcggcggcu     4800

cccccaagaa gaagcggaag gugugacuag caccagccuc aagaacaccc gaauggaguc     4860

ucuaagcuac auaauaccaa cuuacacuuu acaaaauguu gucccccaaa auguagccau     4920

ucguaucugc uccuaauaaa aagaaaguuu cuucacauuc ucucgagaaa aaaaaaaaau     4980

ggaaaaaaaa aaaacggaaa aaaaaaaaag guaaaaaaaa aaaauauaaa aaaaaaaaac     5040

auaaaaaaaa aaaacgaaaa aaaaaaaacg uaaaaaaaaa aaacucaaaa aaaaaaaaga     5100

uaaaaaaaaa aaaccuaaaa aaaaaaaaug uaaaaaaaaa aaagggaaaa aaaaaaaacg     5160

caaaaaaaaa aaacacaaaa aaaaaaaaug caaaaaaaaa aaaucgaaaa aaaaaaaauc     5220

uaaaaaaaaa aaacgaaaaa aaaaaaaccc aaaaaaaaaa aagacaaaaa aaaaaaauag     5280

aaaaaaaaaa aaguuaaaaa aaaaaaacug aaaaaaaaaa aauuuaaaaa aaaaaaaucu     5340

ag                                                                    5342


<210>  372
<211>  3318
<212>  ADN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  372
atgaccggtg ccgccttcaa gcccaacccc atcaactaca tcctgggcct ggacatcggc       60

atcgcctccg tgggctgggc catggtggag atcgacgagg aggagaaccc catccggctg      120

atcgacctgg gcgtgcgggt gttcgagcgg gccgaggtgc ccaagaccgg cgactccctg      180

gccatggccc ggcggctggc ccggtccgtg cggcggctga cccggcggcg ggcccaccgg      240

ctgctgcggg cccggcggct gctgaagcgg gagggcgtgc tgcaggccgc cgacttcgac      300

gagaacggcc tgatcaagtc cctgcccaac accccctggc agctgcgggc cgccgccctg      360

gaccggaagc tgacccccct ggagtggtcc gccgtgctgc tgcacctgat caagcaccgg      420

ggctacctgt cccagcggaa gaacgagggc gagaccgccg acaaggagct gggcgccctg      480

ctgaagggcg tggccaacaa cgcccacgcc ctgcagaccg gcgacttccg gacccccgcc      540

gagctggccc tgaacaagtt cgagaaggag tccggccaca tccggaacca gcggggcgac      600

tactcccaca ccttctcccg gaaggacctg caggccgagc tgatcctgct gttcgagaag      660

cagaaggagt tcggcaaccc ccacgtgtcc ggcggcctga aggagggcat cgagaccctg      720

ctgatgaccc agcggcccgc cctgtccggc gacgccgtgc agaagatgct gggccactgc      780

accttcgagc ccgccgagcc caaggccgcc aagaacacct acaccgccga gcggttcatc      840

tggctgacca agctgaacaa cctgcggatc ctggagcagg gctccgagcg gcccctgacc      900

gacaccgagc gggccaccct gatggacgag ccctaccgga agtccaagct gacctacgcc      960

caggcccgga agctgctggg cctggaggac accgccttct tcaagggcct gcggtacggc     1020

aaggacaacg ccgaggcctc caccctgatg gagatgaagg cctaccacgc catctcccgg     1080

gccctggaga aggagggcct gaaggacaag aagtcccccc tgaacctgtc ctccgagctg     1140

caggacgaga tcggcaccgc cttctccctg ttcaagaccg acgaggacat caccggccgg     1200

ctgaaggacc gggtgcagcc cgagatcctg gaggccctgc tgaagcacat ctccttcgac     1260

aagttcgtgc agatctccct gaaggccctg cggcggatcg tgcccctgat ggagcagggc     1320

aagcggtacg acgaggcctg cgccgagatc tacggcgacc actacggcaa gaagaacacc     1380

gaggagaaga tctacctgcc ccccatcccc gccgacgaga tccggaaccc cgtggtgctg     1440

cgggccctgt cccaggcccg gaaggtgatc aacggcgtgg tgcggcggta cggctccccc     1500

gcccggatcc acatcgagac cgcccgggag gtgggcaagt ccttcaagga ccggaaggag     1560

atcgagaagc ggcaggagga gaaccggaag gaccgggaga aggccgccgc caagttccgg     1620

gagtacttcc ccaacttcgt gggcgagccc aagtccaagg acatcctgaa gctgcggctg     1680

tacgagcagc agcacggcaa gtgcctgtac tccggcaagg agatcaacct ggtgcggctg     1740

aacgagaagg gctacgtgga gatcgaccac gccctgccct tctcccggac ctgggacgac     1800

tccttcaaca acaaggtgct ggtgctgggc tccgagaacc agaacaaggg caaccagacc     1860

ccctacgagt acttcaacgg caaggacaac tcccgggagt ggcaggagtt caaggcccgg     1920

gtggagacct cccggttccc ccggtccaag aagcagcgga tcctgctgca gaagttcgac     1980

gaggacggct tcaaggagtg caacctgaac gacacccggt acgtgaaccg cttcctgtgc     2040

cagttcgtgg ccgaccacat cctgctgacc ggcaagggca agcggcgggt gttcgcctcc     2100

aacggccaga tcaccaacct gctgcggggc ttctggggcc tgcggaaggt gcgggccgag     2160

aacgaccggc accacgccct ggacgccgtg gtggtggcct gctccaccgt ggccatgcag     2220

cagaagatca cccggttcgt gcggtacaag gagatgaacg ccttcgacgg caagaccatc     2280

gacaaggaga ccggcaaggt gctgcaccag aagacccact tcccccagcc ctgggagttc     2340

ttcgcccagg aggtgatgat ccgggtgttc ggcaagcccg acggcaagcc cgagttcgag     2400

gaggccgaca cccccgagaa gctgcggacc ctgctggccg agaagctgtc ctcccggccc     2460

gaggccgtgc acgagtacgt gacccccctg ttcgtgtccc gggcccccaa ccggaagatg     2520

tccggcgccc acaaggacac cctgcggtcc gccaagcggt tcgtgaagca caacgagaag     2580

atctccgtga agcgggtgtg gctgaccgag atcaagctgg ccgacctgga gaacatggtg     2640

aactacaaga acggccggga gatcgagctg tacgaggccc tgaaggcccg gctggaggcc     2700

tacggcggca acgccaagca ggccttcgac cccaaggaca accccttcta caagaagggc     2760

ggccagctgg tgaaggccgt gcgggtggag aagacccagg agtccggcgt gctgctgaac     2820

aagaagaacg cctacaccat cgccgacaac ggcgacatgg tgcgggtgga cgtgttctgc     2880

aaggtggaca agaagggcaa gaaccagtac ttcatcgtgc ccatctacgc ctggcaggtg     2940

gccgagaaca tcctgcccga catcgactgc aagggctacc ggatcgacga ctcctacacc     3000

ttctgcttct ccctgcacaa gtacgacctg atcgccttcc agaaggacga gaagtccaag     3060

gtggagttcg cctactacat caactgcgac tcctccaacg gccggttcta cctggcctgg     3120

cacgacaagg gctccaagga gcagcagttc cggatctcca cccagaacct ggtgctgatc     3180

cagaagtacc aggtgaacga gctgggcaag gagatccggc cctgccggct gaagaagcgg     3240

ccccccgtgc ggtccggaaa gcggaccgcc gacggctccg agttcgagtc ccccaagaag     3300

aagcggaagg tggagtag                                                   3318


<210>  373
<211>  327
<212>  ADN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  373
atgaccaacc tgtccgacat catcgagaag gagaccggca agcagctggt gatccaggag       60

tccatcctga tgctgcccga ggaggtggag gaggtgatcg gcaacaagcc cgagtccgac      120

atcctggtgc acaccgccta cgacgagtcc accgacgaga acgtgatgct gctgacctcc      180

gacgcccccg agtacaagcc ctgggccctg gtgatccagg actccaacgg cgagaacaag      240

atcaagatgc tgtccggcgg ctccaagcgg accgccgacg gctccgagtt cgagtccccc      300

aagaagaagc ggaaggtgga gtgatag                                          327


<210>  374
<211>  3333
<212>  ADN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  374
atggtgccca agaagaagcg gaaggtggcc gccttcaagc ccaaccccat caactacatc       60

ctgggcctgg acatcggcat cgcctccgtg ggctgggcca tggtggagat cgacgaggag      120

gagaacccca tccggctgat cgacctgggc gtgcgggtgt tcgagcgggc cgaggtgccc      180

aagaccggcg actccctggc catggcccgg cggctggccc ggtccgtgcg gcggctgacc      240

cggcggcggg cccaccggct gctgcgggcc cggcggctgc tgaagcggga gggcgtgctg      300

caggccgccg acttcgacga gaacggcctg atcaagtccc tgcccaacac cccctggcag      360

ctgcgggccg ccgccctgga ccggaagctg acccccctgg agtggtccgc cgtgctgctg      420

cacctgatca agcaccgggg ctacctgtcc cagcggaaga acgagggcga gaccgccgac      480

aaggagctgg gcgccctgct gaagggcgtg gccaacaacg cccacgccct gcagaccggc      540

gacttccgga cccccgccga gctggccctg aacaagttcg agaaggagtc cggccacatc      600

cggaaccagc ggggcgacta ctcccacacc ttctcccgga aggacctgca ggccgagctg      660

atcctgctgt tcgagaagca gaaggagttc ggcaaccccc acgtgtccgg cggcctgaag      720

gagggcatcg agaccctgct gatgacccag cggcccgccc tgtccggcga cgccgtgcag      780

aagatgctgg gccactgcac cttcgagccc gccgagccca aggccgccaa gaacacctac      840

accgccgagc ggttcatctg gctgaccaag ctgaacaacc tgcggatcct ggagcagggc      900

tccgagcggc ccctgaccga caccgagcgg gccaccctga tggacgagcc ctaccggaag      960

tccaagctga cctacgccca ggcccggaag ctgctgggcc tggaggacac cgccttcttc     1020

aagggcctgc ggtacggcaa ggacaacgcc gaggcctcca ccctgatgga gatgaaggcc     1080

taccacgcca tctcccgggc cctggagaag gagggcctga aggacaagaa gtcccccctg     1140

aacctgtcct ccgagctgca ggacgagatc ggcaccgcct tctccctgtt caagaccgac     1200

gaggacatca ccggccggct gaaggaccgg gtgcagcccg agatcctgga ggccctgctg     1260

aagcacatct ccttcgacaa gttcgtgcag atctccctga aggccctgcg gcggatcgtg     1320

cccctgatgg agcagggcaa gcggtacgac gaggcctgcg ccgagatcta cggcgaccac     1380

tacggcaaga agaacaccga ggagaagatc tacctgcccc ccatccccgc cgacgagatc     1440

cggaaccccg tggtgctgcg ggccctgtcc caggcccgga aggtgatcaa cggcgtggtg     1500

cggcggtacg gctcccccgc ccggatccac atcgagaccg cccgggaggt gggcaagtcc     1560

ttcaaggacc ggaaggagat cgagaagcgg caggaggaga accggaagga ccgggagaag     1620

gccgccgcca agttccggga gtacttcccc aacttcgtgg gcgagcccaa gtccaaggac     1680

atcctgaagc tgcggctgta cgagcagcag cacggcaagt gcctgtactc cggcaaggag     1740

atcaacctgg tgcggctgaa cgagaagggc tacgtggaga tcgaccacgc cctgcccttc     1800

tcccggacct gggacgactc cttcaacaac aaggtgctgg tgctgggctc cgagaaccag     1860

aacaagggca accagacccc ctacgagtac ttcaacggca aggacaactc ccgggagtgg     1920

caggagttca aggcccgggt ggagacctcc cggttccccc ggtccaagaa gcagcggatc     1980

ctgctgcaga agttcgacga ggacggcttc aaggagtgca acctgaacga cacccggtac     2040

gtgaaccggt tcctgtgcca gttcgtggcc gaccacatcc tgctgaccgg caagggcaag     2100

cggcgggtgt tcgcctccaa cggccagatc accaacctgc tgcggggctt ctggggcctg     2160

cggaaggtgc gggccgagaa cgaccggcac cacgccctgg acgccgtggt ggtggcctgc     2220

tccaccgtgg ccatgcagca gaagatcacc cggttcgtgc ggtacaagga gatgaacgcc     2280

ttcgacggca agaccatcga caaggagacc ggcaaggtgc tgcaccagaa gacccacttc     2340

ccccagccct gggagttctt cgcccaggag gtgatgatcc gggtgttcgg caagcccgac     2400

ggcaagcccg agttcgagga ggccgacacc cccgagaagc tgcggaccct gctggccgag     2460

aagctgtcct cccggcccga ggccgtgcac gagtacgtga cccccctgtt cgtgtcccgg     2520

gcccccaacc ggaagatgtc cggcgcccac aaggacaccc tgcggtccgc caagcggttc     2580

gtgaagcaca acgagaagat ctccgtgaag cgggtgtggc tgaccgagat caagctggcc     2640

gacctggaga acatggtgaa ctacaagaac ggccgggaga tcgagctgta cgaggccctg     2700

aaggcccggc tggaggccta cggcggcaac gccaagcagg ccttcgaccc caaggacaac     2760

cccttctaca agaagggcgg ccagctggtg aaggccgtgc gggtggagaa gacccaggag     2820

tccggcgtgc tgctgaacaa gaagaacgcc tacaccatcg ccgacaacgg cgacatggtg     2880

cgggtggacg tgttctgcaa ggtggacaag aagggcaaga accagtactt catcgtgccc     2940

atctacgcct ggcaggtggc cgagaacatc ctgcccgaca tcgactgcaa gggctaccgg     3000

atcgacgact cctacacctt ctgcttctcc ctgcacaagt acgacctgat cgccttccag     3060

aaggacgaga agtccaaggt ggagttcgcc tactacatca actgcgactc ctccaacggc     3120

cggttctacc tggcctggca cgacaagggc tccaaggagc agcagttccg gatctccacc     3180

cagaacctgg tgctgatcca gaagtaccag gtgaacgagc tgggcaagga gatccggccc     3240

tgccggctga agaagcggcc ccccgtgcgg tacccctacg acgtgcccga ctacgccgcc     3300

gcccccgccg ccaagaagaa gaagctggac tag                                  3333


<210>  375
<211>  3246
<212>  ADN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  375
atggccgcct tcaagcccaa ccccatcaac tacatcctgg gcctggacat cggcatcgcc       60

tccgtgggct gggccatggt ggagatcgac gaggaggaga accccatccg gctgatcgac      120

ctgggcgtgc gggtgttcga gcgggccgag gtgcccaaga ccggcgactc cctggccatg      180

gcccggcggc tggcccggtc cgtgcggcgg ctgacccggc ggcgggccca ccggctgctg      240

cgggcccggc ggctgctgaa gcgggagggc gtgctgcagg ccgccgactt cgacgagaac      300

ggcctgatca agtccctgcc caacaccccc tggcagctgc gggccgccgc cctggaccgg      360

aagctgaccc ccctggagtg gtccgccgtg ctgctgcacc tgatcaagca ccggggctac      420

ctgtcccagc ggaagaacga gggcgagacc gccgacaagg agctgggcgc cctgctgaag      480

ggcgtggcca acaacgccca cgccctgcag accggcgact tccggacccc cgccgagctg      540

gccctgaaca agttcgagaa ggagtccggc cacatccgga accagcgggg cgactactcc      600

cacaccttct cccggaagga cctgcaggcc gagctgatcc tgctgttcga gaagcagaag      660

gagttcggca acccccacgt gtccggcggc ctgaaggagg gcatcgagac cctgctgatg      720

acccagcggc ccgccctgtc cggcgacgcc gtgcagaaga tgctgggcca ctgcaccttc      780

gagcccgccg agcccaaggc cgccaagaac acctacaccg ccgagcggtt catctggctg      840

accaagctga acaacctgcg gatcctggag cagggctccg agcggcccct gaccgacacc      900

gagcgggcca ccctgatgga cgagccctac cggaagtcca agctgaccta cgcccaggcc      960

cggaagctgc tgggcctgga ggacaccgcc ttcttcaagg gcctgcggta cggcaaggac     1020

aacgccgagg cctccaccct gatggagatg aaggcctacc acgccatctc ccgggccctg     1080

gagaaggagg gcctgaagga caagaagtcc cccctgaacc tgtcctccga gctgcaggac     1140

gagatcggca ccgccttctc cctgttcaag accgacgagg acatcaccgg ccggctgaag     1200

gaccgggtgc agcccgagat cctggaggcc ctgctgaagc acatctcctt cgacaagttc     1260

gtgcagatct ccctgaaggc cctgcggcgg atcgtgcccc tgatggagca gggcaagcgg     1320

tacgacgagg cctgcgccga gatctacggc gaccactacg gcaagaagaa caccgaggag     1380

aagatctacc tgccccccat ccccgccgac gagatccgga accccgtggt gctgcgggcc     1440

ctgtcccagg cccggaaggt gatcaacggc gtggtgcggc ggtacggctc ccccgcccgg     1500

atccacatcg agaccgcccg ggaggtgggc aagtccttca aggaccggaa ggagatcgag     1560

aagcggcagg aggagaaccg gaaggaccgg gagaaggccg ccgccaagtt ccgggagtac     1620

ttccccaact tcgtgggcga gcccaagtcc aaggacatcc tgaagctgcg gctgtacgag     1680

cagcagcacg gcaagtgcct gtactccggc aaggagatca acctggtgcg gctgaacgag     1740

aagggctacg tggagatcga ccacgccctg cccttctccc ggacctggga cgactccttc     1800

aacaacaagg tgctggtgct gggctccgag aaccagaaca agggcaacca gaccccctac     1860

gagtacttca acggcaagga caactcccgg gagtggcagg agttcaaggc ccgggtggag     1920

acctcccggt tcccccggtc caagaagcag cggatcctgc tgcagaagtt cgacgaggac     1980

ggcttcaagg agtgcaacct gaacgacacc cggtacgtga accggttcct gtgccagttc     2040

gtggccgacc acatcctgct gaccggcaag ggcaagcggc gggtgttcgc ctccaacggc     2100

cagatcacca acctgctgcg gggcttctgg ggcctgcgga aggtgcgggc cgagaacgac     2160

cggcaccacg ccctggacgc cgtggtggtg gcctgctcca ccgtggccat gcagcagaag     2220

atcacccggt tcgtgcggta caaggagatg aacgccttcg acggcaagac catcgacaag     2280

gagaccggca aggtgctgca ccagaagacc cacttccccc agccctggga gttcttcgcc     2340

caggaggtga tgatccgggt gttcggcaag cccgacggca agcccgagtt cgaggaggcc     2400

gacacccccg agaagctgcg gaccctgctg gccgagaagc tgtcctcccg gcccgaggcc     2460

gtgcacgagt acgtgacccc cctgttcgtg tcccgggccc ccaaccggaa gatgtccggc     2520

gcccacaagg acaccctgcg gtccgccaag cggttcgtga agcacaacga gaagatctcc     2580

gtgaagcggg tgtggctgac cgagatcaag ctggccgacc tggagaacat ggtgaactac     2640

aagaacggcc gggagatcga gctgtacgag gccctgaagg cccggctgga ggcctacggc     2700

ggcaacgcca agcaggcctt cgaccccaag gacaacccct tctacaagaa gggcggccag     2760

ctggtgaagg ccgtgcgggt ggagaagacc caggagtccg gcgtgctgct gaacaagaag     2820

aacgcctaca ccatcgccga caacggcgac atggtgcggg tggacgtgtt ctgcaaggtg     2880

gacaagaagg gcaagaacca gtacttcatc gtgcccatct acgcctggca ggtggccgag     2940

aacatcctgc ccgacatcga ctgcaagggc taccggatcg acgactccta caccttctgc     3000

ttctccctgc acaagtacga cctgatcgcc ttccagaagg acgagaagtc caaggtggag     3060

ttcgcctact acatcaactg cgactcctcc aacggccggt tctacctggc ctggcacgac     3120

aagggctcca aggagcagca gttccggatc tccacccaga acctggtgct gatccagaag     3180

taccaggtga acgagctggg caaggagatc cggccctgcc ggctgaagaa gcggcccccc     3240

gtgcgg                                                                3246


<210>  376
<211>  3366
<212>  ADN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  376
atggacggct ccggcggcgg ctcccccaag aagaagcgga aggtgggcgg ctccggcggc       60

ggcgccgcct tcaagcccaa ccccatcaac tacatcctgg gcctggacat cggcatcgcc      120

tccgtgggct gggccatggt ggagatcgac gaggaggaga accccatccg gctgatcgac      180

ctgggcgtgc gggtgttcga gcgggccgag gtgcccaaga ccggcgactc cctggccatg      240

gcccggcggc tggcccggtc cgtgcggcgg ctgacccggc ggcgggccca ccggctgctg      300

cgggcccggc ggctgctgaa gcgggagggc gtgctgcagg ccgccgactt cgacgagaac      360

ggcctgatca agtccctgcc caacaccccc tggcagctgc gggccgccgc cctggaccgg      420

aagctgaccc ccctggagtg gtccgccgtg ctgctgcacc tgatcaagca ccggggctac      480

ctgtcccagc ggaagaacga gggcgagacc gccgacaagg agctgggcgc cctgctgaag      540

ggcgtggcca acaacgccca cgccctgcag accggcgact tccggacccc cgccgagctg      600

gccctgaaca agttcgagaa ggagtccggc cacatccgga accagcgggg cgactactcc      660

cacaccttct cccggaagga cctgcaggcc gagctgatcc tgctgttcga gaagcagaag      720

gagttcggca acccccacgt gtccggcggc ctgaaggagg gcatcgagac cctgctgatg      780

acccagcggc ccgccctgtc cggcgacgcc gtgcagaaga tgctgggcca ctgcaccttc      840

gagcccgccg agcccaaggc cgccaagaac acctacaccg ccgagcggtt catctggctg      900

accaagctga acaacctgcg gatcctggag cagggctccg agcggcccct gaccgacacc      960

gagcgggcca ccctgatgga cgagccctac cggaagtcca agctgaccta cgcccaggcc     1020

cggaagctgc tgggcctgga ggacaccgcc ttcttcaagg gcctgcggta cggcaaggac     1080

aacgccgagg cctccaccct gatggagatg aaggcctacc acgccatctc ccgggccctg     1140

gagaaggagg gcctgaagga caagaagtcc cccctgaacc tgtcctccga gctgcaggac     1200

gagatcggca ccgccttctc cctgttcaag accgacgagg acatcaccgg ccggctgaag     1260

gaccgggtgc agcccgagat cctggaggcc ctgctgaagc acatctcctt cgacaagttc     1320

gtgcagatct ccctgaaggc cctgcggcgg atcgtgcccc tgatggagca gggcaagcgg     1380

tacgacgagg cctgcgccga gatctacggc gaccactacg gcaagaagaa caccgaggag     1440

aagatctacc tgccccccat ccccgccgac gagatccgga accccgtggt gctgcgggcc     1500

ctgtcccagg cccggaaggt gatcaacggc gtggtgcggc ggtacggctc ccccgcccgg     1560

atccacatcg agaccgcccg ggaggtgggc aagtccttca aggaccggaa ggagatcgag     1620

aagcggcagg aggagaaccg gaaggaccgg gagaaggccg ccgccaagtt ccgggagtac     1680

ttccccaact tcgtgggcga gcccaagtcc aaggacatcc tgaagctgcg gctgtacgag     1740

cagcagcacg gcaagtgcct gtactccggc aaggagatca acctggtgcg gctgaacgag     1800

aagggctacg tggagatcga ccacgccctg cccttctccc ggacctggga cgactccttc     1860

aacaacaagg tgctggtgct gggctccgag aaccagaaca agggcaacca gaccccctac     1920

gagtacttca acggcaagga caactcccgg gagtggcagg agttcaaggc ccgggtggag     1980

acctcccggt tcccccggtc caagaagcag cggatcctgc tgcagaagtt cgacgaggac     2040

ggcttcaagg agtgcaacct gaacgacacc cggtacgtga accggttcct gtgccagttc     2100

gtggccgacc acatcctgct gaccggcaag ggcaagcggc gggtgttcgc ctccaacggc     2160

cagatcacca acctgctgcg gggcttctgg ggcctgcgga aggtgcgggc cgagaacgac     2220

cggcaccacg ccctggacgc cgtggtggtg gcctgctcca ccgtggccat gcagcagaag     2280

atcacccggt tcgtgcggta caaggagatg aacgccttcg acggcaagac catcgacaag     2340

gagaccggca aggtgctgca ccagaagacc cacttccccc agccctggga gttcttcgcc     2400

caggaggtga tgatccgggt gttcggcaag cccgacggca agcccgagtt cgaggaggcc     2460

gacacccccg agaagctgcg gaccctgctg gccgagaagc tgtcctcccg gcccgaggcc     2520

gtgcacgagt acgtgacccc cctgttcgtg tcccgggccc ccaaccggaa gatgtccggc     2580

gcccacaagg acaccctgcg gtccgccaag cggttcgtga agcacaacga gaagatctcc     2640

gtgaagcggg tgtggctgac cgagatcaag ctggccgacc tggagaacat ggtgaactac     2700

aagaacggcc gggagatcga gctgtacgag gccctgaagg cccggctgga ggcctacggc     2760

ggcaacgcca agcaggcctt cgaccccaag gacaacccct tctacaagaa gggcggccag     2820

ctggtgaagg ccgtgcgggt ggagaagacc caggagtccg gcgtgctgct gaacaagaag     2880

aacgcctaca ccatcgccga caacggcgac atggtgcggg tggacgtgtt ctgcaaggtg     2940

gacaagaagg gcaagaacca gtacttcatc gtgcccatct acgcctggca ggtggccgag     3000

aacatcctgc ccgacatcga ctgcaagggc taccggatcg acgactccta caccttctgc     3060

ttctccctgc acaagtacga cctgatcgcc ttccagaagg acgagaagtc caaggtggag     3120

ttcgcctact acatcaactg cgactcctcc aacggccggt tctacctggc ctggcacgac     3180

aagggctcca aggagcagca gttccggatc tccacccaga acctggtgct gatccagaag     3240

taccaggtga acgagctggg caaggagatc cggccctgcc ggctgaagaa gcggcccccc     3300

gtgcggtccg agtccgccac ccccgagtcc gtgtccggct ggcggctgtt caagaagatc     3360

tcctag                                                                3366


<210>  377
<211>  3375
<212>  ADN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  377
atggacggct ccggcggcgg ctcccccaag aagaagcgga aggtgggcgg ctccggcggc       60

ggcgccgcct tcaagcccaa ccccatcaac tacatcctgg gcctggacat cggcatcgcc      120

tccgtgggct gggccatggt ggagatcgac gaggaggaga accccatccg gctgatcgac      180

ctgggcgtgc gggtgttcga gcgggccgag gtgcccaaga ccggcgactc cctggccatg      240

gcccggcggc tggcccggtc cgtgcggcgg ctgacccggc ggcgggccca ccggctgctg      300

cgggcccggc ggctgctgaa gcgggagggc gtgctgcagg ccgccgactt cgacgagaac      360

ggcctgatca agtccctgcc caacaccccc tggcagctgc gggccgccgc cctggaccgg      420

aagctgaccc ccctggagtg gtccgccgtg ctgctgcacc tgatcaagca ccggggctac      480

ctgtcccagc ggaagaacga gggcgagacc gccgacaagg agctgggcgc cctgctgaag      540

ggcgtggcca acaacgccca cgccctgcag accggcgact tccggacccc cgccgagctg      600

gccctgaaca agttcgagaa ggagtccggc cacatccgga accagcgggg cgactactcc      660

cacaccttct cccggaagga cctgcaggcc gagctgatcc tgctgttcga gaagcagaag      720

gagttcggca acccccacgt gtccggcggc ctgaaggagg gcatcgagac cctgctgatg      780

acccagcggc ccgccctgtc cggcgacgcc gtgcagaaga tgctgggcca ctgcaccttc      840

gagcccgccg agcccaaggc cgccaagaac acctacaccg ccgagcggtt catctggctg      900

accaagctga acaacctgcg gatcctggag cagggctccg agcggcccct gaccgacacc      960

gagcgggcca ccctgatgga cgagccctac cggaagtcca agctgaccta cgcccaggcc     1020

cggaagctgc tgggcctgga ggacaccgcc ttcttcaagg gcctgcggta cggcaaggac     1080

aacgccgagg cctccaccct gatggagatg aaggcctacc acgccatctc ccgggccctg     1140

gagaaggagg gcctgaagga caagaagtcc cccctgaacc tgtcctccga gctgcaggac     1200

gagatcggca ccgccttctc cctgttcaag accgacgagg acatcaccgg ccggctgaag     1260

gaccgggtgc agcccgagat cctggaggcc ctgctgaagc acatctcctt cgacaagttc     1320

gtgcagatct ccctgaaggc cctgcggcgg atcgtgcccc tgatggagca gggcaagcgg     1380

tacgacgagg cctgcgccga gatctacggc gaccactacg gcaagaagaa caccgaggag     1440

aagatctacc tgccccccat ccccgccgac gagatccgga accccgtggt gctgcgggcc     1500

ctgtcccagg cccggaaggt gatcaacggc gtggtgcggc ggtacggctc ccccgcccgg     1560

atccacatcg agaccgcccg ggaggtgggc aagtccttca aggaccggaa ggagatcgag     1620

aagcggcagg aggagaaccg gaaggaccgg gagaaggccg ccgccaagtt ccgggagtac     1680

ttccccaact tcgtgggcga gcccaagtcc aaggacatcc tgaagctgcg gctgtacgag     1740

cagcagcacg gcaagtgcct gtactccggc aaggagatca acctggtgcg gctgaacgag     1800

aagggctacg tggagatcga ccacgccctg cccttctccc ggacctggga cgactccttc     1860

aacaacaagg tgctggtgct gggctccgag aaccagaaca agggcaacca gaccccctac     1920

gagtacttca acggcaagga caactcccgg gagtggcagg agttcaaggc ccgggtggag     1980

acctcccggt tcccccggtc caagaagcag cggatcctgc tgcagaagtt cgacgaggac     2040

ggcttcaagg agtgcaacct gaacgacacc cggtacgtga accggttcct gtgccagttc     2100

gtggccgacc acatcctgct gaccggcaag ggcaagcggc gggtgttcgc ctccaacggc     2160

cagatcacca acctgctgcg gggcttctgg ggcctgcgga aggtgcgggc cgagaacgac     2220

cggcaccacg ccctggacgc cgtggtggtg gcctgctcca ccgtggccat gcagcagaag     2280

atcacccggt tcgtgcggta caaggagatg aacgccttcg acggcaagac catcgacaag     2340

gagaccggca aggtgctgca ccagaagacc cacttccccc agccctggga gttcttcgcc     2400

caggaggtga tgatccgggt gttcggcaag cccgacggca agcccgagtt cgaggaggcc     2460

gacacccccg agaagctgcg gaccctgctg gccgagaagc tgtcctcccg gcccgaggcc     2520

gtgcacgagt acgtgacccc cctgttcgtg tcccgggccc ccaaccggaa gatgtccggc     2580

gcccacaagg acaccctgcg gtccgccaag cggttcgtga agcacaacga gaagatctcc     2640

gtgaagcggg tgtggctgac cgagatcaag ctggccgacc tggagaacat ggtgaactac     2700

aagaacggcc gggagatcga gctgtacgag gccctgaagg cccggctgga ggcctacggc     2760

ggcaacgcca agcaggcctt cgaccccaag gacaacccct tctacaagaa gggcggccag     2820

ctggtgaagg ccgtgcgggt ggagaagacc caggagtccg gcgtgctgct gaacaagaag     2880

aacgcctaca ccatcgccga caacggcgac atggtgcggg tggacgtgtt ctgcaaggtg     2940

gacaagaagg gcaagaacca gtacttcatc gtgcccatct acgcctggca ggtggccgag     3000

aacatcctgc ccgacatcga ctgcaagggc taccggatcg acgactccta caccttctgc     3060

ttctccctgc acaagtacga cctgatcgcc ttccagaagg acgagaagtc caaggtggag     3120

ttcgcctact acatcaactg cgactcctcc aacggccggt tctacctggc ctggcacgac     3180

aagggctcca aggagcagca gttccggatc tccacccaga acctggtgct gatccagaag     3240

taccaggtga acgagctggg caaggagatc cggccctgcc ggctgaagaa gcggcccccc     3300

gtgcggtccg gaaagcggac cgccgacggc tccggaggag gaagccccgc cgccaagaag     3360

aagaagctgg actag                                                      3375


<210>  378
<211>  3363
<212>  ADN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  378
atggacggct ccggcggcgg ctcccccaag aagaagcgga aggtggagga caagcggccc       60

gccgccacca agaaggccgg ccaggccaag aagaagaagg gcggctccgg cggcggcgcc      120

gccttcaagc ccaaccccat caactacatc ctgggcctgg acatcggcat cgcctccgtg      180

ggctgggcca tggtggagat cgacgaggag gagaacccca tccggctgat cgacctgggc      240

gtgcgggtgt tcgagcgggc cgaggtgccc aagaccggcg actccctggc catggcccgg      300

cggctggccc ggtccgtgcg gcggctgacc cggcggcggg cccaccggct gctgcgggcc      360

cggcggctgc tgaagcggga gggcgtgctg caggccgccg acttcgacga gaacggcctg      420

atcaagtccc tgcccaacac cccctggcag ctgcgggccg ccgccctgga ccggaagctg      480

acccccctgg agtggtccgc cgtgctgctg cacctgatca agcaccgggg ctacctgtcc      540

cagcggaaga acgagggcga gaccgccgac aaggagctgg gcgccctgct gaagggcgtg      600

gccaacaacg cccacgccct gcagaccggc gacttccgga cccccgccga gctggccctg      660

aacaagttcg agaaggagtc cggccacatc cggaaccagc ggggcgacta ctcccacacc      720

ttctcccgga aggacctgca ggccgagctg atcctgctgt tcgagaagca gaaggagttc      780

ggcaaccccc acgtgtccgg cggcctgaag gagggcatcg agaccctgct gatgacccag      840

cggcccgccc tgtccggcga cgccgtgcag aagatgctgg gccactgcac cttcgagccc      900

gccgagccca aggccgccaa gaacacctac accgccgagc ggttcatctg gctgaccaag      960

ctgaacaacc tgcggatcct ggagcagggc tccgagcggc ccctgaccga caccgagcgg     1020

gccaccctga tggacgagcc ctaccggaag tccaagctga cctacgccca ggcccggaag     1080

ctgctgggcc tggaggacac cgccttcttc aagggcctgc ggtacggcaa ggacaacgcc     1140

gaggcctcca ccctgatgga gatgaaggcc taccacgcca tctcccgggc cctggagaag     1200

gagggcctga aggacaagaa gtcccccctg aacctgtcct ccgagctgca ggacgagatc     1260

ggcaccgcct tctccctgtt caagaccgac gaggacatca ccggccggct gaaggaccgg     1320

gtgcagcccg agatcctgga ggccctgctg aagcacatct ccttcgacaa gttcgtgcag     1380

atctccctga aggccctgcg gcggatcgtg cccctgatgg agcagggcaa gcggtacgac     1440

gaggcctgcg ccgagatcta cggcgaccac tacggcaaga agaacaccga ggagaagatc     1500

tacctgcccc ccatccccgc cgacgagatc cggaaccccg tggtgctgcg ggccctgtcc     1560

caggcccgga aggtgatcaa cggcgtggtg cggcggtacg gctcccccgc ccggatccac     1620

atcgagaccg cccgggaggt gggcaagtcc ttcaaggacc ggaaggagat cgagaagcgg     1680

caggaggaga accggaagga ccgggagaag gccgccgcca agttccggga gtacttcccc     1740

aacttcgtgg gcgagcccaa gtccaaggac atcctgaagc tgcggctgta cgagcagcag     1800

cacggcaagt gcctgtactc cggcaaggag atcaacctgg tgcggctgaa cgagaagggc     1860

tacgtggaga tcgaccacgc cctgcccttc tcccggacct gggacgactc cttcaacaac     1920

aaggtgctgg tgctgggctc cgagaaccag aacaagggca accagacccc ctacgagtac     1980

ttcaacggca aggacaactc ccgggagtgg caggagttca aggcccgggt ggagacctcc     2040

cggttccccc ggtccaagaa gcagcggatc ctgctgcaga agttcgacga ggacggcttc     2100

aaggagtgca acctgaacga cacccggtac gtgaaccggt tcctgtgcca gttcgtggcc     2160

gaccacatcc tgctgaccgg caagggcaag cggcgggtgt tcgcctccaa cggccagatc     2220

accaacctgc tgcggggctt ctggggcctg cggaaggtgc gggccgagaa cgaccggcac     2280

cacgccctgg acgccgtggt ggtggcctgc tccaccgtgg ccatgcagca gaagatcacc     2340

cggttcgtgc ggtacaagga gatgaacgcc ttcgacggca agaccatcga caaggagacc     2400

ggcaaggtgc tgcaccagaa gacccacttc ccccagccct gggagttctt cgcccaggag     2460

gtgatgatcc gggtgttcgg caagcccgac ggcaagcccg agttcgagga ggccgacacc     2520

cccgagaagc tgcggaccct gctggccgag aagctgtcct cccggcccga ggccgtgcac     2580

gagtacgtga cccccctgtt cgtgtcccgg gcccccaacc ggaagatgtc cggcgcccac     2640

aaggacaccc tgcggtccgc caagcggttc gtgaagcaca acgagaagat ctccgtgaag     2700

cgggtgtggc tgaccgagat caagctggcc gacctggaga acatggtgaa ctacaagaac     2760

ggccgggaga tcgagctgta cgaggccctg aaggcccggc tggaggccta cggcggcaac     2820

gccaagcagg ccttcgaccc caaggacaac cccttctaca agaagggcgg ccagctggtg     2880

aaggccgtgc gggtggagaa gacccaggag tccggcgtgc tgctgaacaa gaagaacgcc     2940

tacaccatcg ccgacaacgg cgacatggtg cgggtggacg tgttctgcaa ggtggacaag     3000

aagggcaaga accagtactt catcgtgccc atctacgcct ggcaggtggc cgagaacatc     3060

ctgcccgaca tcgactgcaa gggctaccgg atcgacgact cctacacctt ctgcttctcc     3120

ctgcacaagt acgacctgat cgccttccag aaggacgaga agtccaaggt ggagttcgcc     3180

tactacatca actgcgactc ctccaacggc cggttctacc tggcctggca cgacaagggc     3240

tccaaggagc agcagttccg gatctccacc cagaacctgg tgctgatcca gaagtaccag     3300

gtgaacgagc tgggcaagga gatccggccc tgccggctga agaagcggcc ccccgtgcgg     3360

tag                                                                   3363


<210>  379
<211>  3420
<212>  ADN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  379
atggacggct ccggcggcgg ctcccccaag aagaagcgga aggtggagga caagcggccc       60

gccgccacca agaaggccgg ccaggccaag aagaagaagg gcggctccgg cggcggcgcc      120

gccttcaagc ccaaccccat caactacatc ctgggcctgg acatcggcat cgcctccgtg      180

ggctgggcca tggtggagat cgacgaggag gagaacccca tccggctgat cgacctgggc      240

gtgcgggtgt tcgagcgggc cgaggtgccc aagaccggcg actccctggc catggcccgg      300

cggctggccc ggtccgtgcg gcggctgacc cggcggcggg cccaccggct gctgcgggcc      360

cggcggctgc tgaagcggga gggcgtgctg caggccgccg acttcgacga gaacggcctg      420

atcaagtccc tgcccaacac cccctggcag ctgcgggccg ccgccctgga ccggaagctg      480

acccccctgg agtggtccgc cgtgctgctg cacctgatca agcaccgggg ctacctgtcc      540

cagcggaaga acgagggcga gaccgccgac aaggagctgg gcgccctgct gaagggcgtg      600

gccaacaacg cccacgccct gcagaccggc gacttccgga cccccgccga gctggccctg      660

aacaagttcg agaaggagtc cggccacatc cggaaccagc ggggcgacta ctcccacacc      720

ttctcccgga aggacctgca ggccgagctg atcctgctgt tcgagaagca gaaggagttc      780

ggcaaccccc acgtgtccgg cggcctgaag gagggcatcg agaccctgct gatgacccag      840

cggcccgccc tgtccggcga cgccgtgcag aagatgctgg gccactgcac cttcgagccc      900

gccgagccca aggccgccaa gaacacctac accgccgagc ggttcatctg gctgaccaag      960

ctgaacaacc tgcggatcct ggagcagggc tccgagcggc ccctgaccga caccgagcgg     1020

gccaccctga tggacgagcc ctaccggaag tccaagctga cctacgccca ggcccggaag     1080

ctgctgggcc tggaggacac cgccttcttc aagggcctgc ggtacggcaa ggacaacgcc     1140

gaggcctcca ccctgatgga gatgaaggcc taccacgcca tctcccgggc cctggagaag     1200

gagggcctga aggacaagaa gtcccccctg aacctgtcct ccgagctgca ggacgagatc     1260

ggcaccgcct tctccctgtt caagaccgac gaggacatca ccggccggct gaaggaccgg     1320

gtgcagcccg agatcctgga ggccctgctg aagcacatct ccttcgacaa gttcgtgcag     1380

atctccctga aggccctgcg gcggatcgtg cccctgatgg agcagggcaa gcggtacgac     1440

gaggcctgcg ccgagatcta cggcgaccac tacggcaaga agaacaccga ggagaagatc     1500

tacctgcccc ccatccccgc cgacgagatc cggaaccccg tggtgctgcg ggccctgtcc     1560

caggcccgga aggtgatcaa cggcgtggtg cggcggtacg gctcccccgc ccggatccac     1620

atcgagaccg cccgggaggt gggcaagtcc ttcaaggacc ggaaggagat cgagaagcgg     1680

caggaggaga accggaagga ccgggagaag gccgccgcca agttccggga gtacttcccc     1740

aacttcgtgg gcgagcccaa gtccaaggac atcctgaagc tgcggctgta cgagcagcag     1800

cacggcaagt gcctgtactc cggcaaggag atcaacctgg tgcggctgaa cgagaagggc     1860

tacgtggaga tcgaccacgc cctgcccttc tcccggacct gggacgactc cttcaacaac     1920

aaggtgctgg tgctgggctc cgagaaccag aacaagggca accagacccc ctacgagtac     1980

ttcaacggca aggacaactc ccgggagtgg caggagttca aggcccgggt ggagacctcc     2040

cggttccccc ggtccaagaa gcagcggatc ctgctgcaga agttcgacga ggacggcttc     2100

aaggagtgca acctgaacga cacccggtac gtgaaccggt tcctgtgcca gttcgtggcc     2160

gaccacatcc tgctgaccgg caagggcaag cggcgggtgt tcgcctccaa cggccagatc     2220

accaacctgc tgcggggctt ctggggcctg cggaaggtgc gggccgagaa cgaccggcac     2280

cacgccctgg acgccgtggt ggtggcctgc tccaccgtgg ccatgcagca gaagatcacc     2340

cggttcgtgc ggtacaagga gatgaacgcc ttcgacggca agaccatcga caaggagacc     2400

ggcaaggtgc tgcaccagaa gacccacttc ccccagccct gggagttctt cgcccaggag     2460

gtgatgatcc gggtgttcgg caagcccgac ggcaagcccg agttcgagga ggccgacacc     2520

cccgagaagc tgcggaccct gctggccgag aagctgtcct cccggcccga ggccgtgcac     2580

gagtacgtga cccccctgtt cgtgtcccgg gcccccaacc ggaagatgtc cggcgcccac     2640

aaggacaccc tgcggtccgc caagcggttc gtgaagcaca acgagaagat ctccgtgaag     2700

cgggtgtggc tgaccgagat caagctggcc gacctggaga acatggtgaa ctacaagaac     2760

ggccgggaga tcgagctgta cgaggccctg aaggcccggc tggaggccta cggcggcaac     2820

gccaagcagg ccttcgaccc caaggacaac cccttctaca agaagggcgg ccagctggtg     2880

aaggccgtgc gggtggagaa gacccaggag tccggcgtgc tgctgaacaa gaagaacgcc     2940

tacaccatcg ccgacaacgg cgacatggtg cgggtggacg tgttctgcaa ggtggacaag     3000

aagggcaaga accagtactt catcgtgccc atctacgcct ggcaggtggc cgagaacatc     3060

ctgcccgaca tcgactgcaa gggctaccgg atcgacgact cctacacctt ctgcttctcc     3120

ctgcacaagt acgacctgat cgccttccag aaggacgaga agtccaaggt ggagttcgcc     3180

tactacatca actgcgactc ctccaacggc cggttctacc tggcctggca cgacaagggc     3240

tccaaggagc agcagttccg gatctccacc cagaacctgg tgctgatcca gaagtaccag     3300

gtgaacgagc tgggcaagga gatccggccc tgccggctga agaagcggcc ccccgtgcgg     3360

tccgagtccg ccacccccga gtccgtgtcc ggctggcggc tgttcaagaa gatctcctag     3420


<210>  380
<211>  3342
<212>  ADN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  380
atggacggct ccggcggcgg ctccgaggac aagcggcccg ccgccaccaa gaaggccggc       60

caggccaaga agaagaaggg cggctccggc ggcggcgccg ccttcaagcc caaccccatc      120

aactacatcc tgggcctgga catcggcatc gcctccgtgg gctgggccat ggtggagatc      180

gacgaggagg agaaccccat ccggctgatc gacctgggcg tgcgggtgtt cgagcgggcc      240

gaggtgccca agaccggcga ctccctggcc atggcccggc ggctggcccg gtccgtgcgg      300

cggctgaccc ggcggcgggc ccaccggctg ctgcgggccc ggcggctgct gaagcgggag      360

ggcgtgctgc aggccgccga cttcgacgag aacggcctga tcaagtccct gcccaacacc      420

ccctggcagc tgcgggccgc cgccctggac cggaagctga cccccctgga gtggtccgcc      480

gtgctgctgc acctgatcaa gcaccggggc tacctgtccc agcggaagaa cgagggcgag      540

accgccgaca aggagctggg cgccctgctg aagggcgtgg ccaacaacgc ccacgccctg      600

cagaccggcg acttccggac ccccgccgag ctggccctga acaagttcga gaaggagtcc      660

ggccacatcc ggaaccagcg gggcgactac tcccacacct tctcccggaa ggacctgcag      720

gccgagctga tcctgctgtt cgagaagcag aaggagttcg gcaaccccca cgtgtccggc      780

ggcctgaagg agggcatcga gaccctgctg atgacccagc ggcccgccct gtccggcgac      840

gccgtgcaga agatgctggg ccactgcacc ttcgagcccg ccgagcccaa ggccgccaag      900

aacacctaca ccgccgagcg gttcatctgg ctgaccaagc tgaacaacct gcggatcctg      960

gagcagggct ccgagcggcc cctgaccgac accgagcggg ccaccctgat ggacgagccc     1020

taccggaagt ccaagctgac ctacgcccag gcccggaagc tgctgggcct ggaggacacc     1080

gccttcttca agggcctgcg gtacggcaag gacaacgccg aggcctccac cctgatggag     1140

atgaaggcct accacgccat ctcccgggcc ctggagaagg agggcctgaa ggacaagaag     1200

tcccccctga acctgtcctc cgagctgcag gacgagatcg gcaccgcctt ctccctgttc     1260

aagaccgacg aggacatcac cggccggctg aaggaccggg tgcagcccga gatcctggag     1320

gccctgctga agcacatctc cttcgacaag ttcgtgcaga tctccctgaa ggccctgcgg     1380

cggatcgtgc ccctgatgga gcagggcaag cggtacgacg aggcctgcgc cgagatctac     1440

ggcgaccact acggcaagaa gaacaccgag gagaagatct acctgccccc catccccgcc     1500

gacgagatcc ggaaccccgt ggtgctgcgg gccctgtccc aggcccggaa ggtgatcaac     1560

ggcgtggtgc ggcggtacgg ctcccccgcc cggatccaca tcgagaccgc ccgggaggtg     1620

ggcaagtcct tcaaggaccg gaaggagatc gagaagcggc aggaggagaa ccggaaggac     1680

cgggagaagg ccgccgccaa gttccgggag tacttcccca acttcgtggg cgagcccaag     1740

tccaaggaca tcctgaagct gcggctgtac gagcagcagc acggcaagtg cctgtactcc     1800

ggcaaggaga tcaacctggt gcggctgaac gagaagggct acgtggagat cgaccacgcc     1860

ctgcccttct cccggacctg ggacgactcc ttcaacaaca aggtgctggt gctgggctcc     1920

gagaaccaga acaagggcaa ccagaccccc tacgagtact tcaacggcaa ggacaactcc     1980

cgggagtggc aggagttcaa ggcccgggtg gagacctccc ggttcccccg gtccaagaag     2040

cagcggatcc tgctgcagaa gttcgacgag gacggcttca aggagtgcaa cctgaacgac     2100

acccggtacg tgaaccggtt cctgtgccag ttcgtggccg accacatcct gctgaccggc     2160

aagggcaagc ggcgggtgtt cgcctccaac ggccagatca ccaacctgct gcggggcttc     2220

tggggcctgc ggaaggtgcg ggccgagaac gaccggcacc acgccctgga cgccgtggtg     2280

gtggcctgct ccaccgtggc catgcagcag aagatcaccc ggttcgtgcg gtacaaggag     2340

atgaacgcct tcgacggcaa gaccatcgac aaggagaccg gcaaggtgct gcaccagaag     2400

acccacttcc cccagccctg ggagttcttc gcccaggagg tgatgatccg ggtgttcggc     2460

aagcccgacg gcaagcccga gttcgaggag gccgacaccc ccgagaagct gcggaccctg     2520

ctggccgaga agctgtcctc ccggcccgag gccgtgcacg agtacgtgac ccccctgttc     2580

gtgtcccggg cccccaaccg gaagatgtcc ggcgcccaca aggacaccct gcggtccgcc     2640

aagcggttcg tgaagcacaa cgagaagatc tccgtgaagc gggtgtggct gaccgagatc     2700

aagctggccg acctggagaa catggtgaac tacaagaacg gccgggagat cgagctgtac     2760

gaggccctga aggcccggct ggaggcctac ggcggcaacg ccaagcaggc cttcgacccc     2820

aaggacaacc ccttctacaa gaagggcggc cagctggtga aggccgtgcg ggtggagaag     2880

acccaggagt ccggcgtgct gctgaacaag aagaacgcct acaccatcgc cgacaacggc     2940

gacatggtgc gggtggacgt gttctgcaag gtggacaaga agggcaagaa ccagtacttc     3000

atcgtgccca tctacgcctg gcaggtggcc gagaacatcc tgcccgacat cgactgcaag     3060

ggctaccgga tcgacgactc ctacaccttc tgcttctccc tgcacaagta cgacctgatc     3120

gccttccaga aggacgagaa gtccaaggtg gagttcgcct actacatcaa ctgcgactcc     3180

tccaacggcc ggttctacct ggcctggcac gacaagggct ccaaggagca gcagttccgg     3240

atctccaccc agaacctggt gctgatccag aagtaccagg tgaacgagct gggcaaggag     3300

atccggccct gccggctgaa gaagcggccc cccgtgcggt ag                        3342


<210>  381
<211>  4005
<212>  ADN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  381
atggacggct ccggcggcgg ctcccccaag aagaagcgga aggtggagga caagcggccc       60

gccgccacca agaaggccgg ccaggccaag aagaagaagg gcggctccgg cggcggcgag      120

gcctcccccg cctccggccc ccggcacctg atggaccccc acatcttcac ctccaacttc      180

aacaacggca tcggccggca caagacctac ctgtgctacg aggtggagcg gctggacaac      240

ggcacctccg tgaagatgga ccagcaccgg ggcttcctgc acaaccaggc caagaacctg      300

ctgtgcggct tctacggccg gcacgccgag ctgcggttcc tggacctggt gccctccctg      360

cagctggacc ccgcccagat ctaccgggtg acctggttca tctcctggtc cccctgcttc      420

tcctggggct gcgccggcga ggtgcgggcc ttcctgcagg agaacaccca cgtgcggctg      480

cggatcttcg ccgcccggat ctacgactac gaccccctgt acaaggaggc cctgcagatg      540

ctgcgggacg ccggcgccca ggtgtccatc atgacctacg acgagttcaa gcactgctgg      600

gacaccttcg tggaccacca gggctgcccc ttccagccct gggacggcct ggacgagcac      660

tcccaggccc tgtccggccg gctgcgggcc atcctgcaga accagggcaa ctccggctcc      720

gagacccccg gcacctccga gtccgccacc cccgagtccg cagcgttcaa accaaatccc      780

atcaactaca tcctgggcct ggccatcggc atcgcctccg tgggctgggc catggtggag      840

atcgacgagg aggagaaccc catccggctg atcgacctgg gcgtgcgggt gttcgagcgg      900

gccgaggtgc ccaagaccgg cgactccctg gccatggccc ggcggctggc ccggtccgtg      960

cggcggctga cccggcggcg ggcccaccgg ctgctgcggg cccggcggct gctgaagcgg     1020

gagggcgtgc tgcaggccgc cgacttcgac gagaacggcc tgatcaagtc cctgcccaac     1080

accccctggc agctgcgggc cgccgccctg gaccggaagc tgacccccct ggagtggtcc     1140

gccgtgctgc tgcacctgat caagcaccgg ggctacctgt cccagcggaa gaacgagggc     1200

gagaccgccg acaaggagct gggcgccctg ctgaagggcg tggccaacaa cgcccacgcc     1260

ctgcagaccg gcgacttccg gacccccgcc gagctggccc tgaacaagtt cgagaaggag     1320

tccggccaca tccggaacca gcggggcgac tactcccaca ccttctcccg gaaggacctg     1380

caggccgagc tgatcctgct gttcgagaag cagaaggagt tcggcaaccc ccacgtgtcc     1440

ggcggcctga aggagggcat cgagaccctg ctgatgaccc agcggcccgc cctgtccggc     1500

gacgccgtgc agaagatgct gggccactgc accttcgagc ccgccgagcc caaggccgcc     1560

aagaacacct acaccgccga gcggttcatc tggctgacca agctgaacaa cctgcggatc     1620

ctggagcagg gctccgagcg gcccctgacc gacaccgagc gggccaccct gatggacgag     1680

ccctaccgga agtccaagct gacctacgcc caggcccgga agctgctggg cctggaggac     1740

accgccttct tcaagggcct gcggtacggc aaggacaacg ccgaggcctc caccctgatg     1800

gagatgaagg cctaccacgc catctcccgg gccctggaga aggagggcct gaaggacaag     1860

aagtcccccc tgaacctgtc ctccgagctg caggacgaga tcggcaccgc cttctccctg     1920

ttcaagaccg acgaggacat caccggccgg ctgaaggacc gggtgcagcc cgagatcctg     1980

gaggccctgc tgaagcacat ctccttcgac aagttcgtgc agatctccct gaaggccctg     2040

cggcggatcg tgcccctgat ggagcagggc aagcggtacg acgaggcctg cgccgagatc     2100

tacggcgacc actacggcaa gaagaacacc gaggagaaga tctacctgcc ccccatcccc     2160

gccgacgaga tccggaaccc cgtggtgctg cgggccctgt cccaggcccg gaaggtgatc     2220

aacggcgtgg tgcggcggta cggctccccc gcccggatcc acatcgagac cgcccgggag     2280

gtgggcaagt ccttcaagga ccggaaggag atcgagaagc ggcaggagga gaaccggaag     2340

gaccgggaga aggccgccgc caagttccgg gagtacttcc ccaacttcgt gggcgagccc     2400

aagtccaagg acatcctgaa gctgcggctg tacgagcagc agcacggcaa gtgcctgtac     2460

tccggcaagg agatcaacct ggtgcggctg aacgagaagg gctacgtgga gatcgaccac     2520

gccctgccct tctcccggac ctgggacgac tccttcaaca acaaggtgct ggtgctgggc     2580

tccgagaacc agaacaaggg caaccagacc ccctacgagt acttcaacgg caaggacaac     2640

tcccgggagt ggcaggagtt caaggcccgg gtggagacct cccggttccc ccggtccaag     2700

aagcagcgga tcctgctgca gaagttcgac gaggacggct tcaaggagtg caacctgaac     2760

gacacccggt acgtgaaccg cttcctgtgc cagttcgtgg ccgaccacat cctgctgacc     2820

ggcaagggca agcggcgggt gttcgcctcc aacggccaga tcaccaacct gctgcggggc     2880

ttctggggcc tgcggaaggt gcgggccgag aacgaccggc accacgccct ggacgccgtg     2940

gtggtggcct gctccaccgt ggccatgcag cagaagatca cccggttcgt gcggtacaag     3000

gagatgaacg ccttcgacgg caagaccatc gacaaggaga ccggcaaggt gctgcaccag     3060

aagacccact tcccccagcc ctgggagttc ttcgcccagg aggtgatgat ccgggtgttc     3120

ggcaagcccg acggcaagcc cgagttcgag gaggccgaca cccccgagaa gctgcggacc     3180

ctgctggccg agaagctgtc ctcccggccc gaggccgtgc acgagtacgt gacccccctg     3240

ttcgtgtccc gggcccccaa ccggaagatg tccggcgccc acaaggacac cctgcggtcc     3300

gccaagcggt tcgtgaagca caacgagaag atctccgtga agcgggtgtg gctgaccgag     3360

atcaagctgg ccgacctgga gaacatggtg aactacaaga acggccggga gatcgagctg     3420

tacgaggccc tgaaggcccg gctggaggcc tacggcggca acgccaagca ggccttcgac     3480

cccaaggaca accccttcta caagaagggc ggccagctgg tgaaggccgt gcgggtggag     3540

aagacccagg agtccggcgt gctgctgaac aagaagaacg cctacaccat cgccgacaac     3600

ggcgacatgg tgcgggtgga cgtgttctgc aaggtggaca agaagggcaa gaaccagtac     3660

ttcatcgtgc ccatctacgc ctggcaggtg gccgagaaca tcctgcccga catcgactgc     3720

aagggctacc ggatcgacga ctcctacacc ttctgcttct ccctgcacaa gtacgacctg     3780

atcgccttcc agaaggacga gaagtccaag gtggagttcg cctactacat caactgcgac     3840

tcctccaacg gccggttcta cctggcctgg cacgacaagg gctccaagga gcagcagttc     3900

cggatctcca cccagaacct ggtgctgatc cagaagtacc aggtgaacga gctgggcaag     3960

gagatccggc cctgccggct gaagaagcgg ccccccgtgc ggtag                     4005


<210>  382
<211>  4782
<212>  ADN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  382
atggaggcct cccccgcctc cggcccccgg cacctgatgg acccccacat cttcacctcc       60

aacttcaaca acggcatcgg ccggcacaag acctacctgt gctacgaggt ggagcggctg      120

gacaacggca cctccgtgaa gatggaccag caccggggct tcctgcacaa ccaggccaag      180

aacctgctgt gcggcttcta cggccggcac gccgagctgc ggttcctgga cctggtgccc      240

tccctgcagc tggaccccgc ccagatctac cgggtgacct ggttcatctc ctggtccccc      300

tgcttctcct ggggctgcgc cggcgaggtg cgggccttcc tgcaggagaa cacccacgtg      360

cggctgcgga tcttcgccgc ccggatctac gactacgacc ccctgtacaa ggaggccctg      420

cagatgctgc gggacgccgg cgcccaggtg tccatcatga cctacgacga gttcaagcac      480

tgctgggaca ccttcgtgga ccaccagggc tgccccttcc agccctggga cggcctggac      540

gagcactccc aggccctgtc cggccggctg cgggccatcc tgcagaacca gggcaactcc      600

ggctccgaga cccccggcac ctccgagtcc gccacccccg agtccgacaa gaagtactcc      660

atcggcctgg ccatcggcac caactccgtg ggctgggccg tgatcaccga cgagtacaag      720

gtgccctcca agaagttcaa ggtgctgggc aacaccgacc ggcactccat caagaagaac      780

ctgatcggcg ccctgctgtt cgactccggc gagaccgccg aggccacccg gctgaagcgg      840

accgcccggc ggcggtacac ccggcggaag aaccggatct gctacctgca ggagatcttc      900

tccaacgaga tggccaaggt ggacgactcc ttcttccacc ggctggagga gtccttcctg      960

gtggaggagg acaagaagca cgagcggcac cccatcttcg gcaacatcgt ggacgaggtg     1020

gcctaccacg agaagtaccc caccatctac cacctgcgga agaagctggt ggactccacc     1080

gacaaggccg acctgcggct gatctacctg gccctggccc acatgatcaa gttccggggc     1140

cacttcctga tcgagggcga cctgaacccc gacaactccg acgtggacaa gctgttcatc     1200

cagctggtgc agacctacaa ccagctgttc gaggagaacc ccatcaacgc ctccggcgtg     1260

gacgccaagg ccatcctgtc cgcccggctg tccaagtccc ggcggctgga gaacctgatc     1320

gcccagctgc ccggcgagaa gaagaacggc ctgttcggca acctgatcgc cctgtccctg     1380

ggcctgaccc ccaacttcaa gtccaacttc gacctggccg aggacgccaa gctgcagctg     1440

tccaaggaca cctacgacga cgacctggac aacctgctgg cccagatcgg cgaccagtac     1500

gccgacctgt tcctggccgc caagaacctg tccgacgcca tcctgctgtc cgacatcctg     1560

cgggtgaaca ccgagatcac caaggccccc ctgtccgcct ccatgatcaa gcggtacgac     1620

gagcaccacc aggacctgac cctgctgaag gccctggtgc ggcagcagct gcccgagaag     1680

tacaaggaga tcttcttcga ccagtccaag aacggctacg ccggctacat cgacggcggc     1740

gcctcccagg aggagttcta caagttcatc aagcccatcc tggagaagat ggacggcacc     1800

gaggagctgc tggtgaagct gaaccgggag gacctgctgc ggaagcagcg gaccttcgac     1860

aacggctcca tcccccacca gatccacctg ggcgagctgc acgccatcct gcggcggcag     1920

gaggacttct accccttcct gaaggacaac cgggagaaga tcgagaagat cctgaccttc     1980

cggatcccct actacgtggg ccccctggcc cggggcaact cccggttcgc ctggatgacc     2040

cggaagtccg aggagaccat caccccctgg aacttcgagg aggtggtgga caagggcgcc     2100

tccgcccagt ccttcatcga gcggatgacc aacttcgaca agaacctgcc caacgagaag     2160

gtgctgccca agcactccct gctgtacgag tacttcaccg tgtacaacga gctgaccaag     2220

gtgaagtacg tgaccgaggg catgcggaag cccgccttcc tgtccggcga gcagaagaag     2280

gccatcgtgg acctgctgtt caagaccaac cggaaggtga ccgtgaagca gctgaaggag     2340

gactacttca agaagatcga gtgcttcgac tccgtggaga tctccggcgt ggaggaccgg     2400

ttcaacgcct ccctgggcac ctaccacgac ctgctgaaga tcatcaagga caaggacttc     2460

ctggacaacg aggagaacga ggacatcctg gaggacatcg tgctgaccct gaccctgttc     2520

gaggaccggg agatgatcga ggagcggctg aagacctacg cccacctgtt cgacgacaag     2580

gtgatgaagc agctgaagcg gcggcggtac accggctggg gccggctgtc ccggaagctg     2640

atcaacggca tccgggacaa gcagtccggc aagaccatcc tggacttcct gaagtccgac     2700

ggcttcgcca accggaactt catgcagctg atccacgacg actccctgac cttcaaggag     2760

gacatccaga aggcccaggt gtccggccag ggcgactccc tgcacgagca catcgccaac     2820

ctggccggct cccccgccat caagaagggc atcctgcaga ccgtgaaggt ggtggacgag     2880

ctggtgaagg tgatgggccg gcacaagccc gagaacatcg tgatcgagat ggcccgggag     2940

aaccagacca cccagaaggg ccagaagaac tcccgggagc ggatgaagcg gatcgaggag     3000

ggcatcaagg agctgggctc ccagatcctg aaggagcacc ccgtggagaa cacccagctg     3060

cagaacgaga agctgtacct gtactacctg cagaacggcc gggacatgta cgtggaccag     3120

gagctggaca tcaaccggct gtccgactac gacgtggacc acatcgtgcc ccagtccttc     3180

ctgaaggacg actccatcga caacaaggtg ctgacccggt ccgacaagaa ccggggcaag     3240

tccgacaacg tgccctccga ggaggtggtg aagaagatga agaactactg gcggcagctg     3300

ctgaacgcca agctgatcac ccagcggaag ttcgacaacc tgaccaaggc cgagcggggc     3360

ggcctgtccg agctggacaa ggccggcttc atcaagcggc agctggtgga gacccggcag     3420

atcaccaagc acgtggccca gatcctggac tcccggatga acaccaagta cgacgagaac     3480

gacaagctga tccgggaggt gaaggtgatc accctgaagt ccaagctggt gtccgacttc     3540

cggaaggact tccagttcta caaggtgcgg gagatcaaca actaccacca cgcccacgac     3600

gcctacctga acgccgtggt gggcaccgcc ctgatcaaga agtaccccaa gctggagtcc     3660

gagttcgtgt acggcgacta caaggtgtac gacgtgcgga agatgatcgc caagtccgag     3720

caggagatcg gcaaggccac cgccaagtac ttcttctact ccaacatcat gaacttcttc     3780

aagaccgaga tcaccctggc caacggcgag atccggaagc ggcccctgat cgagaccaac     3840

ggcgagaccg gcgagatcgt gtgggacaag ggccgggact tcgccaccgt gcggaaggtg     3900

ctgtccatgc cccaggtgaa catcgtgaag aagaccgagg tgcagaccgg cggcttctcc     3960

aaggagtcca tcctgcccaa gcggaactcc gacaagctga tcgcccggaa gaaggactgg     4020

gaccccaaga agtacggcgg cttcgactcc cccaccgtgg cctactccgt gctggtggtg     4080

gccaaggtgg agaagggcaa gtccaagaag ctgaagtccg tgaaggagct gctgggcatc     4140

accatcatgg agcggtcctc cttcgagaag aaccccatcg acttcctgga ggccaagggc     4200

tacaaggagg tgaagaagga cctgatcatc aagctgccca agtactccct gttcgagctg     4260

gagaacggcc ggaagcggat gctggcctcc gccggcgagc tgcagaaggg caacgagctg     4320

gccctgccct ccaagtacgt gaacttcctg tacctggcct cccactacga gaagctgaag     4380

ggctcccccg aggacaacga gcagaagcag ctgttcgtgg agcagcacaa gcactacctg     4440

gacgagatca tcgagcagat ctccgagttc tccaagcggg tgatcctggc cgacgccaac     4500

ctggacaagg tgctgtccgc ctacaacaag caccgggaca agcccatccg ggagcaggcc     4560

gagaacatca tccacctgtt caccctgacc aacctgggcg cccccgccgc cttcaagtac     4620

ttcgacacca ccatcgaccg gaagcggtac acctccacca aggaggtgct ggacgccacc     4680

ctgatccacc agtccatcac cggcctgtac gagacccgga tcgacctgtc ccagctgggc     4740

ggcgacggcg gcggctcccc caagaagaag cggaaggtgt ga                        4782


<210>  383

<400>  383
000

<210>  384

<400>  384
000

<210>  385

<400>  385
000

<210>  386

<400>  386
000

<210>  387

<400>  387
000

<210>  388

<400>  388
000

<210>  389

<400>  389
000

<210>  390

<400>  390
000

<210>  391

<400>  391
000

<210>  392

<400>  392
000

<210>  393

<400>  393
000

<210>  394

<400>  394
000

<210>  395

<400>  395
000

<210>  396

<400>  396
000

<210>  397

<400>  397
000

<210>  398

<400>  398
000

<210>  399

<400>  399
000

<210>  400
<211>  76
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética: Conserved Portion of a spyCas9 sgARN

<400>  400
guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc cguuaucaac uugaaaaagu       60

ggcaccgagu cggugc                                                       76


<210>  401

<400>  401
000

<210>  402

<400>  402
000

<210>  403

<400>  403
000

<210>  404

<400>  404
000

<210>  405

<400>  405
000

<210>  406

<400>  406
000

<210>  407

<400>  407
000

<210>  408

<400>  408
000

<210>  409

<400>  409
000

<210>  410

<400>  410
000

<210>  411

<400>  411
000

<210>  412

<400>  412
000

<210>  413

<400>  413
000

<210>  414

<400>  414
000

<210>  415

<400>  415
000

<210>  416

<400>  416
000

<210>  417

<400>  417
000

<210>  418

<400>  418
000

<210>  419

<400>  419
000

<210>  420

<400>  420
000

<210>  421

<400>  421
000

<210>  422

<400>  422
000

<210>  423

<400>  423
000

<210>  424

<400>  424
000

<210>  425

<400>  425
000

<210>  426

<400>  426
000

<210>  427

<400>  427
000

<210>  428

<400>  428
000

<210>  429

<400>  429
000

<210>  430

<400>  430
000

<210>  431

<400>  431
000

<210>  432

<400>  432
000

<210>  433

<400>  433
000

<210>  434

<400>  434
000

<210>  435

<400>  435
000

<210>  436

<400>  436
000

<210>  437

<400>  437
000

<210>  438

<400>  438
000

<210>  439

<400>  439
000

<210>  440

<400>  440
000

<210>  441

<400>  441
000

<210>  442

<400>  442
000

<210>  443

<400>  443
000

<210>  444

<400>  444
000

<210>  445

<400>  445
000

<210>  446

<400>  446
000

<210>  447

<400>  447
000

<210>  448

<400>  448
000

<210>  449

<400>  449
000

<210>  450

<400>  450
000

<210>  451

<400>  451
000

<210>  452

<400>  452
000

<210>  453

<400>  453
000

<210>  454

<400>  454
000

<210>  455

<400>  455
000

<210>  456

<400>  456
000

<210>  457

<400>  457
000

<210>  458

<400>  458
000

<210>  459

<400>  459
000

<210>  460

<400>  460
000

<210>  461

<400>  461
000

<210>  462

<400>  462
000

<210>  463

<400>  463
000

<210>  464

<400>  464
000

<210>  465

<400>  465
000

<210>  466

<400>  466
000

<210>  467

<400>  467
000

<210>  468

<400>  468
000

<210>  469

<400>  469
000

<210>  470

<400>  470
000

<210>  471

<400>  471
000

<210>  472

<400>  472
000

<210>  473

<400>  473
000

<210>  474

<400>  474
000

<210>  475

<400>  475
000

<210>  476

<400>  476
000

<210>  477

<400>  477
000

<210>  478

<400>  478
000

<210>  479

<400>  479
000

<210>  480

<400>  480
000

<210>  481

<400>  481
000

<210>  482

<400>  482
000

<210>  483

<400>  483
000

<210>  484

<400>  484
000

<210>  485

<400>  485
000

<210>  486

<400>  486
000

<210>  487

<400>  487
000

<210>  488

<400>  488
000

<210>  489

<400>  489
000

<210>  490

<400>  490
000

<210>  491

<400>  491
000

<210>  492

<400>  492
000

<210>  493

<400>  493
000

<210>  494

<400>  494
000

<210>  495

<400>  495
000

<210>  496

<400>  496
000

<210>  497

<400>  497
000

<210>  498

<400>  498
000

<210>  499

<400>  499
000

<210>  500
<211>  145
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<222>  (1)..(24)
<223>  n es a, c, g o u

<400>  500
nnnnnnnnnn nnnnnnnnnn nnnnguugua gcucccuuuc ucauuucgga aacgaaauga       60

gaaccguugc uacaauaagg ccgucugaaa agaugugccg caacgcucug ccccuuaaag      120

cuucugcuuu aaggggcauc guuua                                            145


<210>  501
<211>  105
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<222>  (1)..(24)
<223>  n es a, c, g o u

<400>  501
nnnnnnnnnn nnnnnnnnnn nnnnguugua gcucccuucg aaagaccguu gcuacaauaa       60

ggccgucgaa agaugugccg caacgcucug ccuucuggca ucguu                      105


<210>  502

<400>  502
000

<210>  503

<400>  503
000

<210>  504

<400>  504
000

<210>  505

<400>  505
000

<210>  506

<400>  506
000

<210>  507

<400>  507
000

<210>  508

<400>  508
000

<210>  509

<400>  509
000

<210>  510

<400>  510
000

<210>  511

<400>  511
000

<210>  512

<400>  512
000

<210>  513

<400>  513
000

<210>  514

<400>  514
000

<210>  515

<400>  515
000

<210>  516

<400>  516
000

<210>  517

<400>  517
000

<210>  518

<400>  518
000

<210>  519

<400>  519
000

<210>  520

<400>  520
000

<210>  521

<400>  521
000

<210>  522

<400>  522
000

<210>  523

<400>  523
000

<210>  524

<400>  524
000

<210>  525

<400>  525
000

<210>  526

<400>  526
000

<210>  527

<400>  527
000

<210>  528

<400>  528
000

<210>  529

<400>  529
000

<210>  530

<400>  530
000

<210>  531

<400>  531
000

<210>  532

<400>  532
000

<210>  533

<400>  533
000

<210>  534

<400>  534
000

<210>  535

<400>  535
000

<210>  536

<400>  536
000

<210>  537

<400>  537
000

<210>  538

<400>  538
000

<210>  539

<400>  539
000

<210>  540

<400>  540
000

<210>  541

<400>  541
000

<210>  542

<400>  542
000

<210>  543

<400>  543
000

<210>  544

<400>  544
000

<210>  545

<400>  545
000

<210>  546

<400>  546
000

<210>  547

<400>  547
000

<210>  548

<400>  548
000

<210>  549

<400>  549
000

<210>  550

<400>  550
000

<210>  551

<400>  551
000

<210>  552

<400>  552
000

<210>  553

<400>  553
000

<210>  554

<400>  554
000

<210>  555

<400>  555
000

<210>  556

<400>  556
000

<210>  557

<400>  557
000

<210>  558

<400>  558
000

<210>  559

<400>  559
000

<210>  560

<400>  560
000

<210>  561

<400>  561
000

<210>  562

<400>  562
000

<210>  563

<400>  563
000

<210>  564

<400>  564
000

<210>  565

<400>  565
000

<210>  566

<400>  566
000

<210>  567

<400>  567
000

<210>  568

<400>  568
000

<210>  569

<400>  569
000

<210>  570

<400>  570
000

<210>  571

<400>  571
000

<210>  572

<400>  572
000

<210>  573

<400>  573
000

<210>  574

<400>  574
000

<210>  575

<400>  575
000

<210>  576

<400>  576
000

<210>  577

<400>  577
000

<210>  578

<400>  578
000

<210>  579

<400>  579
000

<210>  580

<400>  580
000

<210>  581

<400>  581
000

<210>  582

<400>  582
000

<210>  583

<400>  583
000

<210>  584

<400>  584
000

<210>  585

<400>  585
000

<210>  586

<400>  586
000

<210>  587

<400>  587
000

<210>  588

<400>  588
000

<210>  589

<400>  589
000

<210>  590

<400>  590
000

<210>  591

<400>  591
000

<210>  592

<400>  592
000

<210>  593

<400>  593
000

<210>  594

<400>  594
000

<210>  595

<400>  595
000

<210>  596

<400>  596
000

<210>  597

<400>  597
000

<210>  598

<400>  598
000

<210>  599

<400>  599
000

<210>  600

<400>  600
000

<210>  601

<400>  601
000

<210>  602

<400>  602
000

<210>  603

<400>  603
000

<210>  604

<400>  604
000

<210>  605

<400>  605
000

<210>  606

<400>  606
000

<210>  607

<400>  607
000

<210>  608

<400>  608
000

<210>  609

<400>  609
000

<210>  610
<211>  101
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  610
ccaagugucu uccaguacga uuugguugua gcucccugaa accguugcua caauaaggcc       60

gucgaaagau gugccgcaac gcucugccuu cuggcaucgu u                          101


<210>  611
<211>  93
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  611
ccaagugucu uccaguacga uuugguugua gcucccuucg accguugcua caauaaggcc       60

gucgaugugc cgcaacgcuc ugccggcauc guu                                    93


<210>  612
<211>  93
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  612
ccaagugucu uccaguacga uuugguugua gcucccuucg accguugcua caauaaggcc       60

gucgaugugc cgcaacgcuc ugccggcauc guu                                    93


<210>  613
<211>  101
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  613
cuucaccagg agaagccguc acacguugua gcucccugaa accguugcua caauaaggcc       60

gucgaaagau gugccgcaac gcucugccuu cuggcaucgu u                          101


<210>  614
<211>  93
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  614
cuucaccagg agaagccguc acacguugua gcucccuucg accguugcua caauaaggcc       60

gucgaugugc cgcaacgcuc ugccggcauc guu                                    93


<210>  615
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  615
ccaagugucu uccaguacga uuugguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  616
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  616
cuucaccagg agaagccguc acacguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  617
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  617
cuucaccagg agaagccguc acacguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  618
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  618
cuucaccagg agaagccguc acacguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  619
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  619
cuucaccagg agaagccguc acacguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  620
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  620
cuucaccagg agaagccguc acacguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  621
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  621
cuucaccagg agaagccguc acacguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  622
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  622
cuucaccagg agaagccguc acacguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  623
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  623
cuucaccagg agaagccguc acacguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  624
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  624
cuucaccagg agaagccguc acacguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  625
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  625
cuucaccagg agaagccguc acacguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  626
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  626
cuucaccagg agaagccguc acacguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  627
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  627
cuucaccagg agaagccguc acacguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  628
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  628
cuucaccagg agaagccguc acacguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  629
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  629
cuucaccagg agaagccguc acacguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  630
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  630
cuucaccagg agaagccguc acacguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  631
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  631
cuucaccagg agaagccguc acacguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  632
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  632
cuucaccagg agaagccguc acacguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  633
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  633
cuucaccagg agaagccguc acacguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  634
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  634
ccaagugucu uccaguacga uuugguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  635
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  635
ccaagugucu uccaguacga uuugguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  636
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  636
ccaagugucu uccaguacga uuugguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  637
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  637
ccaagugucu uccaguacga uuugguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  638
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  638
ccaagugucu uccaguacga uuugguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  639
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  639
ccaagugucu uccaguacga uuugguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  640
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  640
ccaagugucu uccaguacga uuugguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  641
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  641
ccaagugucu uccaguacga uuugguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  642
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  642
ccaagugucu uccaguacga uuugguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  643
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  643
ccaagugucu uccaguacga uuugguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  644
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  644
ccaagugucu uccaguacga uuugguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  645
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  645
ccaagugucu uccaguacga uuugguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  646
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  646
ccaagugucu uccaguacga uuugguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  647
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  647
ccaagugucu uccaguacga uuugguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  648
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  648
ccaagugucu uccaguacga uuugguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  649
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  649
ccaagugucu uccaguacga uuugguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  650
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  650
ccaagugucu uccaguacga uuugguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  651
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  651
cuucaccaag agaagccguc acacguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  652
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  652
ccaagugucu uccaguacga uuugguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  653
<211>  93
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  653
ccaagugucu uccaguacga uuugguugua gcucccuugc accguugcua caauaaggcc       60

gucgaugugc cgcaacgcuc ugccggcauc guu                                    93


<210>  654
<211>  91
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  654
ccaagugucu uccaguacga uuugguugua gcucccugcc cguugcuaca auaaggccgu       60

cgaugugccg caacgcucug ccggcaucgu u                                      91


<210>  655
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  655
ccaagugucu uccaguacga uuugguugua gcucccgccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  656
<211>  87
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  656
ccaagugucu uccaguacga uuugguugua gcuccgcguu gcuacaauaa ggccgucgau       60

gugccgcaac gcucugccgg caucguu                                           87


<210>  657
<211>  85
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  657
ccaagugucu uccaguacga uuugguugua gcuccguugc uacaauaagg ccgucgaugu       60

gccgcaacgc ucugccggca ucguu                                             85


<210>  658
<211>  95
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  658
ccaagugucu uccaguacga uuugguugua gcucccuugc accguugcua caauaaggcc       60

gucuagaugu gccgcaacgc ucugccggca ucguu                                  95


<210>  659
<211>  95
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética

<400>  659
ccaagugucu uccaguacga uuugguugua gcucccuugc accguugcua caauaaggcc       60

gucgaugugc cgcaacgcuc ugccuaggca ucguu                                  95


<210>  660

<400>  660
000

<210>  661

<400>  661
000

<210>  662

<400>  662
000

<210>  663

<400>  663
000

<210>  664

<400>  664
000

<210>  665

<400>  665
000

<210>  666

<400>  666
000

<210>  667

<400>  667
000

<210>  668

<400>  668
000

<210>  669

<400>  669
000

<210>  670

<400>  670
000

<210>  671

<400>  671
000

<210>  672

<400>  672
000

<210>  673

<400>  673
000

<210>  674

<400>  674
000

<210>  675

<400>  675
000

<210>  676

<400>  676
000

<210>  677

<400>  677
000

<210>  678

<400>  678
000

<210>  679

<400>  679
000

<210>  680

<400>  680
000

<210>  681

<400>  681
000

<210>  682

<400>  682
000

<210>  683

<400>  683
000

<210>  684

<400>  684
000

<210>  685

<400>  685
000

<210>  686

<400>  686
000

<210>  687

<400>  687
000

<210>  688

<400>  688
000

<210>  689

<400>  689
000

<210>  690

<400>  690
000

<210>  691

<400>  691
000

<210>  692

<400>  692
000

<210>  693

<400>  693
000

<210>  694

<400>  694
000

<210>  695

<400>  695
000

<210>  696

<400>  696
000

<210>  697

<400>  697
000

<210>  698

<400>  698
000

<210>  699

<400>  699
000

<210>  700

<400>  700
000

<210>  701

<400>  701
000

<210>  702

<400>  702
000

<210>  703

<400>  703
000

<210>  704

<400>  704
000

<210>  705

<400>  705
000

<210>  706

<400>  706
000

<210>  707

<400>  707
000

<210>  708

<400>  708
000

<210>  709

<400>  709
000

<210>  710
<211>  101
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene modificaciones 2'-O-Me y PS ; see specification as filed
       for detailed description of substitutions and preferred 
       embodiments

<400>  710
ccaagugucu uccaguacga uuugguugua gcucccugaa accguugcua caauaaggcc       60

gucgaaagau gugccgcaac gcucugccuu cuggcaucgu u                          101


<210>  711
<211>  93
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS;  vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<400>  711
ccaagugucu uccaguacga uuugguugua gcucccuucg accguugcua caauaaggcc       60

gucgaugugc cgcaacgcuc ugccggcauc guu                                    93


<210>  712
<211>  93
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<400>  712
ccaagugucu uccaguacga uuugguugua gcucccuucg accguugcua caauaaggcc       60

gucgaugugc cgcaacgcuc ugccggcauc guu                                    93


<210>  713
<211>  101
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 

<400>  713
cuucaccagg agaagccguc acacguugua gcucccugaa accguugcua caauaaggcc       60

gucgaaagau gugccgcaac gcucugccuu cuggcaucgu u                          101


<210>  714
<211>  93
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS;  vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<400>  714
cuucaccagg agaagccguc acacguugua gcucccuucg accguugcua caauaaggcc       60

gucgaugugc cgcaacgcuc ugccggcauc guu                                    93


<210>  715
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS;  vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<400>  715
ccaagugucu uccaguacga uuugguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  716
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS;  vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<400>  716
cuucaccagg agaagccguc acacguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  717
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS;  vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<400>  717
cuucaccagg agaagccguc acacguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  718
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS;  vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<400>  718
cuucaccagg agaagccguc acacguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  719
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS;  vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<400>  719
cuucaccagg agaagccguc acacguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  720
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS;  vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<400>  720
cuucaccagg agaagccguc acacguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  721
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS;  vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<400>  721
cuucaccagg agaagccguc acacguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  722
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<400>  722
cuucaccagg agaagccguc acacguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  723
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS;  vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<400>  723
cuucaccagg agaagccguc acacguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  724
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<400>  724
cuucaccagg agaagccguc acacguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  725
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<400>  725
cuucaccagg agaagccguc acacguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  726
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<400>  726
cuucaccagg agaagccguc acacguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  727
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<400>  727
cuucaccagg agaagccguc acacguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  728
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<400>  728
cuucaccagg agaagccguc acacguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  729
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<400>  729
cuucaccagg agaagccguc acacguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  730
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS;  vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<400>  730
cuucaccagg agaagccguc acacguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  731
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS;  vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<400>  731
cuucaccagg agaagccguc acacguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  732
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS;  vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<400>  732
cuucaccagg agaagccguc acacguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  733
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS;  vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<400>  733
cuucaccagg agaagccguc acacguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  734
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<400>  734
ccaagugucu uccaguacga uuugguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  735
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<400>  735
ccaagugucu uccaguacga uuugguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  736
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS;  vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<400>  736
ccaagugucu uccaguacga uuugguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  737
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<400>  737
ccaagugucu uccaguacga uuugguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  738
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS;  vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<400>  738
ccaagugucu uccaguacga uuugguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  739
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<400>  739
ccaagugucu uccaguacga uuugguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  740
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<400>  740
ccaagugucu uccaguacga uuugguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  741
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS;  vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<400>  741
ccaagugucu uccaguacga uuugguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  742
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS;  vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<400>  742
ccaagugucu uccaguacga uuugguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  743
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS;  vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<400>  743
ccaagugucu uccaguacga uuugguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  744
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS;  vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<400>  744
ccaagugucu uccaguacga uuugguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  745
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS;  vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<400>  745
ccaagugucu uccaguacga uuugguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  746
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS;  vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<400>  746
ccaagugucu uccaguacga uuugguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  747
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<400>  747
ccaagugucu uccaguacga uuugguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  748
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<400>  748
ccaagugucu uccaguacga uuugguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  749
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<400>  749
ccaagugucu uccaguacga uuugguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  750
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<400>  750
ccaagugucu uccaguacga uuugguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  751
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS;  vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<400>  751
cuucaccaag agaagccguc acacguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  752
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<400>  752
ccaagugucu uccaguacga uuugguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  753
<211>  93
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<400>  753
ccaagugucu uccaguacga uuugguugua gcucccuugc accguugcua caauaaggcc       60

gucgaugugc cgcaacgcuc ugccggcauc guu                                    93


<210>  754
<211>  91
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<400>  754
ccaagugucu uccaguacga uuugguugua gcucccugcc cguugcuaca auaaggccgu       60

cgaugugccg caacgcucug ccggcaucgu u                                      91


<210>  755
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<400>  755
ccaagugucu uccaguacga uuugguugua gcucccgccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  756
<211>  87
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<400>  756
ccaagugucu uccaguacga uuugguugua gcuccgcguu gcuacaauaa ggccgucgau       60

gugccgcaac gcucugccgg caucguu                                           87


<210>  757
<211>  85
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<400>  757
ccaagugucu uccaguacga uuugguugua gcuccguugc uacaauaagg ccgucgaugu       60

gccgcaacgc ucugccggca ucguu                                             85


<210>  758
<211>  95
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<400>  758
ccaagugucu uccaguacga uuugguugua gcucccuugc accguugcua caauaaggcc       60

gucuagaugu gccgcaacgc ucugccggca ucguu                                  95


<210>  759
<211>  95
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<400>  759
ccaagugucu uccaguacga uuugguugua gcucccuugc accguugcua caauaaggcc       60

gucgaugugc cgcaacgcuc ugccuaggca ucguu                                  95


<210>  760

<400>  760
000

<210>  761

<400>  761
000

<210>  762

<400>  762
000

<210>  763

<400>  763
000

<210>  764

<400>  764
000

<210>  765

<400>  765
000

<210>  766

<400>  766
000

<210>  767

<400>  767
000

<210>  768

<400>  768
000

<210>  769

<400>  769
000

<210>  770

<400>  770
000

<210>  771

<400>  771
000

<210>  772

<400>  772
000

<210>  773

<400>  773
000

<210>  774

<400>  774
000

<210>  775

<400>  775
000

<210>  776

<400>  776
000

<210>  777

<400>  777
000

<210>  778

<400>  778
000

<210>  779

<400>  779
000

<210>  780

<400>  780
000

<210>  781

<400>  781
000

<210>  782

<400>  782
000

<210>  783

<400>  783
000

<210>  784

<400>  784
000

<210>  785

<400>  785
000

<210>  786

<400>  786
000

<210>  787

<400>  787
000

<210>  788

<400>  788
000

<210>  789

<400>  789
000

<210>  790

<400>  790
000

<210>  791

<400>  791
000

<210>  792

<400>  792
000

<210>  793

<400>  793
000

<210>  794

<400>  794
000

<210>  795

<400>  795
000

<210>  796

<400>  796
000

<210>  797

<400>  797
000

<210>  798

<400>  798
000

<210>  799

<400>  799
000

<210>  800

<400>  800
000

<210>  801

<400>  801
000

<210>  802

<400>  802
000

<210>  803

<400>  803
000

<210>  804

<400>  804
000

<210>  805

<400>  805
000

<210>  806

<400>  806
000

<210>  807

<400>  807
000

<210>  808

<400>  808
000

<210>  809

<400>  809
000

<210>  810

<400>  810
000

<210>  811

<400>  811
000

<210>  812

<400>  812
000

<210>  813

<400>  813
000

<210>  814

<400>  814
000

<210>  815

<400>  815
000

<210>  816

<400>  816
000

<210>  817

<400>  817
000

<210>  818

<400>  818
000

<210>  819

<400>  819
000

<210>  820

<400>  820
000

<210>  821

<400>  821
000

<210>  822

<400>  822
000

<210>  823

<400>  823
000

<210>  824

<400>  824
000

<210>  825

<400>  825
000

<210>  826

<400>  826
000

<210>  827

<400>  827
000

<210>  828

<400>  828
000

<210>  829

<400>  829
000

<210>  830

<400>  830
000

<210>  831

<400>  831
000

<210>  832

<400>  832
000

<210>  833

<400>  833
000

<210>  834

<400>  834
000

<210>  835

<400>  835
000

<210>  836

<400>  836
000

<210>  837

<400>  837
000

<210>  838

<400>  838
000

<210>  839

<400>  839
000

<210>  840

<400>  840
000

<210>  841

<400>  841
000

<210>  842

<400>  842
000

<210>  843

<400>  843
000

<210>  844

<400>  844
000

<210>  845

<400>  845
000

<210>  846

<400>  846
000

<210>  847

<400>  847
000

<210>  848

<400>  848
000

<210>  849

<400>  849
000

<210>  850

<400>  850
000

<210>  851

<400>  851
000

<210>  852

<400>  852
000

<210>  853

<400>  853
000

<210>  854

<400>  854
000

<210>  855

<400>  855
000

<210>  856

<400>  856
000

<210>  857

<400>  857
000

<210>  858

<400>  858
000

<210>  859

<400>  859
000

<210>  860

<400>  860
000

<210>  861

<400>  861
000

<210>  862

<400>  862
000

<210>  863

<400>  863
000

<210>  864

<400>  864
000

<210>  865

<400>  865
000

<210>  866

<400>  866
000

<210>  867

<400>  867
000

<210>  868

<400>  868
000

<210>  869

<400>  869
000

<210>  870

<400>  870
000

<210>  871

<400>  871
000

<210>  872

<400>  872
000

<210>  873

<400>  873
000

<210>  874

<400>  874
000

<210>  875

<400>  875
000

<210>  876

<400>  876
000

<210>  877

<400>  877
000

<210>  878

<400>  878
000

<210>  879

<400>  879
000

<210>  880

<400>  880
000

<210>  881

<400>  881
000

<210>  882

<400>  882
000

<210>  883

<400>  883
000

<210>  884

<400>  884
000

<210>  885

<400>  885
000

<210>  886

<400>  886
000

<210>  887

<400>  887
000

<210>  888

<400>  888
000

<210>  889

<400>  889
000

<210>  890

<400>  890
000

<210>  891

<400>  891
000

<210>  892

<400>  892
000

<210>  893

<400>  893
000

<210>  894

<400>  894
000

<210>  895

<400>  895
000

<210>  896

<400>  896
000

<210>  897

<400>  897
000

<210>  898

<400>  898
000

<210>  899

<400>  899
000

<210>  900

<400>  900
000

<210>  901

<400>  901
000

<210>  902

<400>  902
000

<210>  903

<400>  903
000

<210>  904

<400>  904
000

<210>  905

<400>  905
000

<210>  906

<400>  906
000

<210>  907

<400>  907
000

<210>  908

<400>  908
000

<210>  909

<400>  909
000

<210>  910

<400>  910
000

<210>  911

<400>  911
000

<210>  912

<400>  912
000

<210>  913

<400>  913
000

<210>  914

<400>  914
000

<210>  915

<400>  915
000

<210>  916

<400>  916
000

<210>  917

<400>  917
000

<210>  918

<400>  918
000

<210>  919

<400>  919
000

<210>  920

<400>  920
000

<210>  921

<400>  921
000

<210>  922

<400>  922
000

<210>  923

<400>  923
000

<210>  924

<400>  924
000

<210>  925

<400>  925
000

<210>  926

<400>  926
000

<210>  927

<400>  927
000

<210>  928

<400>  928
000

<210>  929

<400>  929
000

<210>  930

<400>  930
000

<210>  931

<400>  931
000

<210>  932

<400>  932
000

<210>  933

<400>  933
000

<210>  934

<400>  934
000

<210>  935

<400>  935
000

<210>  936

<400>  936
000

<210>  937

<400>  937
000

<210>  938

<400>  938
000

<210>  939

<400>  939
000

<210>  940

<400>  940
000

<210>  941

<400>  941
000

<210>  942

<400>  942
000

<210>  943

<400>  943
000

<210>  944

<400>  944
000

<210>  945

<400>  945
000

<210>  946

<400>  946
000

<210>  947

<400>  947
000

<210>  948

<400>  948
000

<210>  949

<400>  949
000

<210>  950

<400>  950
000

<210>  951

<400>  951
000

<210>  952

<400>  952
000

<210>  953

<400>  953
000

<210>  954

<400>  954
000

<210>  955

<400>  955
000

<210>  956

<400>  956
000

<210>  957

<400>  957
000

<210>  958

<400>  958
000

<210>  959

<400>  959
000

<210>  960

<400>  960
000

<210>  961

<400>  961
000

<210>  962

<400>  962
000

<210>  963

<400>  963
000

<210>  964

<400>  964
000

<210>  965

<400>  965
000

<210>  966

<400>  966
000

<210>  967

<400>  967
000

<210>  968

<400>  968
000

<210>  969

<400>  969
000

<210>  970

<400>  970
000

<210>  971

<400>  971
000

<210>  972

<400>  972
000

<210>  973

<400>  973
000

<210>  974

<400>  974
000

<210>  975

<400>  975
000

<210>  976

<400>  976
000

<210>  977

<400>  977
000

<210>  978

<400>  978
000

<210>  979

<400>  979
000

<210>  980

<400>  980
000

<210>  981

<400>  981
000

<210>  982

<400>  982
000

<210>  983

<400>  983
000

<210>  984

<400>  984
000

<210>  985

<400>  985
000

<210>  986

<400>  986
000

<210>  987

<400>  987
000

<210>  988

<400>  988
000

<210>  989

<400>  989
000

<210>  990

<400>  990
000

<210>  991

<400>  991
000

<210>  992

<400>  992
000

<210>  993

<400>  993
000

<210>  994

<400>  994
000

<210>  995

<400>  995
000

<210>  996

<400>  996
000

<210>  997

<400>  997
000

<210>  998

<400>  998
000

<210>  999

<400>  999
000

<210>  1000
<211>  94
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas  

<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  n es a, c, g o u

<220>
<221>  misc_feature
<222>  (21)..(25)
<223>  n puede o no estar presente

<400>  1000
nnnnnnnnnn nnnnnnnnnn nnnnnguugu agcucccuuc gaccguugcu acaauaaggc       60

cgucgaugug ccgcaacgcu cugccggcau cguu                                   94


<210>  1001
<211>  93
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<220>
<221>  misc_feature
<222>  (1)..(24)
<223>  n es a, c, g o u

<400>  1001
nnnnnnnnnn nnnnnnnnnn nnnnguugua gcucccuucg accguugcua caauaaggcc       60

gucgaugugc cgcaacgcuc ugccggcauc guu                                    93


<210>  1002
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<220>
<221>  misc_feature
<222>  (1)..(24)
<223>  n es a, c, g o u

<400>  1002
nnnnnnnnnn nnnnnnnnnn nnnnguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  1003
<211>  89
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<220>
<221>  misc_feature
<222>  (1)..(24)
<223>  n es a, c, g o u

<400>  1003
nnnnnnnnnn nnnnnnnnnn nnnnguugua gcucccuccg uugcuacaau aaggccgucg       60

augugccgca acgcucugcc ggcaucguu                                         89


<210>  1004
<211>  90
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  n es a, c, g o u

<220>
<221>  misc_feature
<222>  (21)..(25)
<223>  n puede o no estar presente

<400>  1004
nnnnnnnnnn nnnnnnnnnn nnnnnguugu agcucccucc guugcuacaa uaaggccguc       60

gaugugccgc aacgcucugc cggcaucguu                                        90


<210>  1005
<211>  94
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  n es a, c, g o u

<220>
<221>  misc_feature
<222>  (21)..(25)
<223>  n puede o no estar presente

<400>  1005
nnnnnnnnnn nnnnnnnnnn nnnnnguugu agcucccuug caccguugcu acaauaaggc       60

cgucgaugug ccgcaacgcu cugccggcau cguu                                   94


<210>  1006
<211>  94
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  n es a, c, g o u

<220>
<221>  misc_feature
<222>  (21)..(25)
<223>  n puede o no estar presente

<400>  1006
nnnnnnnnnn nnnnnnnnnn nnnnnguugu agcucccuug caccguugcu acaauaaggc       60

cgucgaugug ccgcaacgcu cugccggcau cguu                                   94


<210>  1007
<211>  92
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  n es a, c, g o u

<220>
<221>  misc_feature
<222>  (21)..(25)
<223>  n puede o no estar presente

<400>  1007
nnnnnnnnnn nnnnnnnnnn nnnnnguugu agcucccugc ccguugcuac aauaaggccg       60

ucgaugugcc gcaacgcucu gccggcaucg uu                                     92


<210>  1008
<211>  90
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  n es a, c, g o u

<220>
<221>  misc_feature
<222>  (21)..(25)
<223>  n puede o no estar presente

<400>  1008
nnnnnnnnnn nnnnnnnnnn nnnnnguugu agcucccgcc guugcuacaa uaaggccguc       60

gaugugccgc aacgcucugc cggcaucguu                                        90


<210>  1009
<211>  88
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  n es a, c, g o u

<220>
<221>  misc_feature
<222>  (21)..(25)
<223>  n puede o no estar presente

<400>  1009
nnnnnnnnnn nnnnnnnnnn nnnnnguugu agcuccgcgu ugcuacaaua aggccgucga       60

ugugccgcaa cgcucugccg gcaucguu                                          88


<210>  1010
<211>  86
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  n es a, c, g o u

<220>
<221>  misc_feature
<222>  (21)..(25)
<223>  n puede o no estar presente

<400>  1010
nnnnnnnnnn nnnnnnnnnn nnnnnguugu agcuccguug cuacaauaag gccgucgaug       60

ugccgcaacg cucugccggc aucguu                                            86


<210>  1011
<211>  96
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  n es a, c, g o u

<220>
<221>  misc_feature
<222>  (21)..(25)
<223>  n puede o no estar presente

<400>  1011
nnnnnnnnnn nnnnnnnnnn nnnnnguugu agcucccuug caccguugcu acaauaaggc       60

cgucuagaug ugccgcaacg cucugccggc aucguu                                 96


<210>  1012
<211>  96
<212>  ARN
<213>  Secuencia artificial

<220>
<223>  Sintética


<220>
<221>  misc_feature
<223>  contiene conector interno L1, modificaciones 2'-O-Me y PS; vea en la memoria descriptiva presentada una descripción detallada de sustituciones y modalidades preferidas 
        

<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  n es a, c, g o u

<220>
<221>  misc_feature
<222>  (21)..(25)
<223>  n puede o no estar presente

<400>  1012
nnnnnnnnnn nnnnnnnnnn nnnnnguugu agcucccuug caccguugcu acaauaaggc       60

cgucgaugug ccgcaacgcu cugccuaggc aucguu                                 96