WO 43236-0020WO1 US 63/280,409 2021-11-17 Cybrexa 4, Inc. PEPTIDE CONJUGATES OF PEPTIDIC TUBULIN INHIBITORS AS THERAPEUTICS CONJUGADOS PEPTÍDICOS DE INHIBIDORES DE TUBULINA PEPTÍDICA COMO AGENTES TERAPÉUTICOS 311 28 AA PAT

REGION 1..28 note synthetic peptide péptido sintético source 1..28 mol_type protein organism synthetic construct construcción sintética

ADDQNPWRAYLDLLFPTDTLLLDLLWCG 35 AA PAT

REGION 1..35 note synthetic peptide péptido sintético source 1..35 mol_type protein organism synthetic construct construcción sintética

AEQNPIYWARYADWLFTTPLLLLDLALLVDADECG 32 AA PAT

REGION 1..32 note synthetic peptide péptido sintético source 1..32 mol_type protein organism synthetic construct construcción sintética

ADDQNPWRAYLDLLFPTDTLLLDLLWDADECG 39 AA PAT

REGION 1..39 note synthetic peptide péptido sintético SITE 1 note MISC_FEATURE - acetylated MISC_FEATURE - acetilado source 1..39 mol_type protein organism synthetic construct construcción sintética

AAEQNPIYWARYADWLFTTPLLLLDLALLVDADEGTKCG 37 AA PAT

REGION 1..37 note synthetic peptide péptido sintético source 1..37 mol_type protein organism synthetic construct construcción sintética

AAEQNPIYWARYADWLFTTPLLLLDLALLVDADEGTC 39 AA PAT

REGION 1..39 note Description of Unknown: pH-sensitive membrane polypeptide Descripción de desconocido: polipéptido de membrana sensible al pH source 1..39 mol_type protein organism unidentified no identificado

AAEQNPIYWWARYADWLFTTPLLLLDLALLVDADEGTCG 35 AA PAT

REGION 1..35 note Description of Unknown: Wild-type pH-sensitive membranepolypeptide Descripción de desconocido: polipéptido de membrana sensible al pH de tipo salvaje source 1..35 mol_type protein organism unidentified no identificado

AEQNPIYWARYADWLFTTPLLLLDLALLVDADEGT 36 AA PAT

REGION 1..36 note Description of Unknown: Wild-type pH-sensitive membranepolypeptide Descripción de desconocido: polipéptido de membrana sensible al pH de tipo salvaje source 1..36 mol_type protein organism unidentified no identificado

GGEQNPIYWARYADWLFTTPLLLLDLALLVDADEGT 35 AA PAT

AEQNPIYWARYADWLFTTPLLLLDLALLVDADEGT 38 AA PAT

REGION 1..38 note Description of Artificial Sequence: Synthetic polypeptide Descripción de secuencia artificial: Polipéptido sintético source 1..38 mol_type protein organism synthetic construct construcción sintética

AAEQNPIYWARYADWLFTTPLLLLDLALLVDADEGTCG 38 AA PAT

GGEQNPIYWARYADWLFTTPLLLLDLALLVDADEGTCG 37 AA PAT

REGION 1..37 note Description of Artificial Sequence: Synthetic polypeptide Descripción de secuencia artificial: Polipéptido sintético source 1..37 mol_type protein organism synthetic construct construcción sintética

ACEQNPIYWARYADWLFTTPLLLLDLALLVDADEGTG 36 AA PAT

REGION 1..36 note Description of Artificial Sequence: Synthetic polypeptide Descripción de secuencia artificial: Polipéptido sintético source 1..36 mol_type protein organism synthetic construct construcción sintética

ACEQNPIYWARYADWLFTTPLLLLDLALLVDADEGT 36 AA PAT

AKEQNPIYWARYADWLFTTPLLLLDLALLVDADEGT 39 AA PAT

REGION 1..39 note Description of Artificial Sequence: Synthetic polypeptide Descripción de secuencia artificial: Polipéptido sintético source 1..39 mol_type protein organism synthetic construct construcción sintética

AAEQNPIYWARYADWLFTTPLLLLDLALLVDADEGTKCG 36 AA PAT

AKEQNPIYWARYADWLFTTPLLLLDLALLVDADECT 37 AA PAT

ACEQNPIYWARYANWLFTTPLLLLNLALLVDADEGTG 37 AA PAT

ACEQNPIYWARYAKWLFTTPLLLLKLALLVDADEGTG 36 AA PAT

GGEQNPIYWARYADWLFTTPLLLLDLALLVNANQGT 36 AA PAT

AAEQNPIYWARYADWLFTTPLLLLALALLVDADEGT 36 AA PAT

AAEQNPIYWARYAAWLFTTPLLLLDLALLVDADEGT 36 AA PAT

AAEQNPIYWARYADWLFTTALLLLDLALLVDADEGT 36 AA PAT

AAEQNPIYWARYADWLFTTPLLLLELALLVDADEGT 36 AA PAT

AAEQNPIYWARYAEWLFTTPLLLLDLALLVDADEGT 39 AA PAT

AAEQNPIIYWARYADWLFTDLPLLLLDLLALLVDADEGT 37 AA PAT

GEQNPIYWAQYADWLFTTPLLLLDLALLVDADEGTCG 38 AA PAT

GGEQNPIYWARYADWLFTTPLLLDLLALLVDADEGTCG 38 AA PAT

GGEQNPIYWARYADWLFTTPLLLLLDALLVDADEGTCG 38 AA PAT

GGEQNPIYWARYDAWLFTTPLLLLDLALLVDADEGTCG 38 AA PAT

GGEQNPIYWARYAWDLFTTPLLLLDLALLVDADEGTCG 36 AA PAT

AAEQNPIYWARYADWLFTTGLLLLDLALLVDADEGT 37 AA PAT

DDDEDNPIYWARYADWLFTTPLLLLHGALLVDADECT 38 AA PAT

DDDEDNPIYWARYAHWLFTTPLLLLHGALLVDADEGCT 37 AA PAT

DDDEDNPIYWARYAHWLFTTPLLLLHGALLVNADECT 37 AA PAT

DDDEDNPIYWARYAHWLFTTPLLLLHGALLVNANECT 34 AA PAT

REGION 1..34 note Description of Artificial Sequence: Synthetic polypeptide Descripción de secuencia artificial: Polipéptido sintético source 1..34 mol_type protein organism synthetic construct construcción sintética

AEQNPIYWARYADFLFTTPLLLLDLALLVDADET 35 AA PAT

REGION 1..35 note Description of Artificial Sequence: Synthetic polypeptide Descripción de secuencia artificial: Polipéptido sintético source 1..35 mol_type protein organism synthetic construct construcción sintética

AEQNPIYFARYADWLFTTPLLLLDLALLVDADEGT 34 AA PAT

AEQNPIYFARYADFLFTTPLLLLDLALLWDADET 32 AA PAT

REGION 1..32 note Description of Artificial Sequence: Synthetic polypeptide Descripción de secuencia artificial: Polipéptido sintético source 1..32 mol_type protein organism synthetic construct construcción sintética

AKEDQNPYWARYADWLFTTPLLLLDLALLVDG 32 AA PAT

ACEDQNPYWARYADWLFTTPLLLLDLALLVDG 32 AA PAT

AEDQNPYWARYADWLFTTPLLLLDLALLVDCG 32 AA PAT

AEDQNPYWARYADWLFTTPLLLLELALLVECG 30 AA PAT

REGION 1..30 note Description of Artificial Sequence: Synthetic polypeptide Descripción de secuencia artificial: Polipéptido sintético source 1..30 mol_type protein organism synthetic construct construcción sintética

AKEDQNPYWRAYADLFTPLTLLDLLALWDG 30 AA PAT

ACEDQNPYWRAYADLFTPLTLLDLLALWDG 27 AA PAT

REGION 1..27 note Description of Artificial Sequence: Synthetic peptide Descripción de secuencia artificial: péptido sintético source 1..27 mol_type protein organism synthetic construct construcción sintética

ACDDQNPWRAYLDLLFPTDTLLLDLLW 34 AA PAT

TEDADVLLALDLLLLPTTFLWDAYRAWYPNQECA 20 AA PAT

REGION 1..20 note Description of Artificial Sequence: Synthetic peptide Descripción de secuencia artificial: péptido sintético source 1..20 mol_type protein organism synthetic construct construcción sintética

AEQNPIYWARYADWLFTTPL 21 AA PAT

REGION 1..21 note Description of Artificial Sequence: Synthetic peptide Descripción de secuencia artificial: péptido sintético source 1..21 mol_type protein organism synthetic construct construcción sintética

AEQNPIYWARYADWLFTTPCL 21 AA PAT

ACEQNPIYWARYADWLFTTPL 20 AA PAT

AEQNPIYFARYADWLFTTPL 21 AA PAT

KEDQNPWARYADLLFPTTLAW 22 AA PAT

REGION 1..22 note Description of Artificial Sequence: Synthetic peptide Descripción de secuencia artificial: péptido sintético source 1..22 mol_type protein organism synthetic construct construcción sintética

ACEDQNPWARYADLLFPTTLAW 24 AA PAT

REGION 1..24 note Description of Artificial Sequence: Synthetic peptide Descripción de secuencia artificial: péptido sintético source 1..24 mol_type protein organism synthetic construct construcción sintética

ACEDQNPWARYADWLFPTTLLLLD 22 AA PAT

ACEEQNPWARYAELLFPTTLAW 24 AA PAT

ACEEQNPWARYAEWLFPTTLLLLE 25 AA PAT

REGION 1..25 note Description of Artificial Sequence: Synthetic peptide Descripción de secuencia artificial: péptido sintético source 1..25 mol_type protein organism synthetic construct construcción sintética

ACEEQNPWARYLEWLFPTETLLLEL 36 AA PAT

GGEQNPIYWARYADWLFTTPLLLLDLALLVDADEGT 35 AA PAT

ACEQNPIYWARYADWLFTTPLLLLDLALLVDADET 38 AA PAT

AAEQNPIYWARYADWLFTTPLLLLDLALLVDADEGTCG 36 AA PAT

AEQNPIYWARYADWLFTTPLLLLDLALLVDADEGCT 38 AA PAT

GGEQNPIYWARYADWLFTTPLLLLDLALLVDADEGTCG 36 AA PAT

ACEQNPIYWARYADWLFTTPLLLLDLALLVDADEGT 36 AA PAT

AKEQNPIYWARYADWLFTTPLLLLDLALLVDADEGT 36 AA PAT

AKEQNPIYWARYADWLFTTPLLLLDLALLVDADECT 36 AA PAT

AAEQNPIYWARYADWLFTTALLLLDLALLVDADEGT 37 AA PAT

ACAEQNPIYWARYADWLFTTGLLLLDLALLVDADEGT 34 AA PAT

AEQNPIYWARYADFLFTTPLLLLDLALLVDADET 35 AA PAT

AEQNPIYFARYADWLFTTPLLLLDLALLVDADEGT 34 AA PAT

AEQNPIYFARYADFLFTTPLLLLDLALLWDADET 32 AA PAT

AKEDQNPYWARYADWLFTTPLLLLDLALLVDG 32 AA PAT

ACEDQNPYWARYADWLFTTPLLLLDLALLVDG 31 AA PAT

REGION 1..31 note Description of Artificial Sequence: Synthetic polypeptide Descripción de secuencia artificial: Polipéptido sintético source 1..31 mol_type protein organism synthetic construct construcción sintética

AEDQNPYWARYADWLFTTPLLLLDLALLVDG 32 AA PAT

AEDQNPYWARYADWLFTTPLLLLELALLVECG 30 AA PAT

AKEDQNPYWRAYADLFTPLTLLDLLALWDG 30 AA PAT

ACEDQNPYWRAYADLFTPLTLLDLLALWDG 32 AA PAT

AKEDQNDPYWARYADWLFTTPLLLLDLALLVG 34 AA PAT

TEDADVLLALDLLLLPTTFLWDAYRAWYPNQECA 36 AA PAT

GGEQNPIYWARYADWLFTTPLLLLDLALLVDADEGT 20 AA PAT

AEQNPIYWARYADWLFTTPL 21 AA PAT

AEQNPIYWARYADWLFTTPCL 21 AA PAT

ACEQNPIYWARYADWLFTTPL 21 AA PAT

ACEQNPIYFARYADWLFTTPL 27 AA PAT

ACDDQNPWRAYLDLLFPTDTLLLDLLW 27 AA PAT

ACEEQNPWRAYLELLFPTETLLLELLW 25 AA PAT

ACDDQNPWARYLDWLFPTDTLLLDL 24 AA PAT

CDNNNPWRAYLDLLFPTDTLLLDW 25 AA PAT

ACEEQNPWARYLEWLFPTETLLLEL 24 AA PAT

ACEDQNPWARYADWLFPTTLLLLD 24 AA PAT

ACEEQNPWARYAEWLFPTTLLLLE 22 AA PAT

ACEDQNPWARYADLLFPTTLAW 21 AA PAT

ACEDQNPWARYAELLFPTTLW 20 AA PAT

KEDQNPWARYADLLFPTTLW 37 AA PAT

DDDEDNPIYWARYAHWLFTTPLLLLHGALLVDADECT 37 AA PAT

DDDEDNPIYWARYAHWLFTTPLLLLDGALLVDADECT 37 AA PAT

DDDEDNPIYWARYAHWLFTTPLLLLHGALLVNADECT 37 AA PAT

DDDEDNPIYWARYAHWLFTTPLLLLHGALLVNANECT 37 AA PAT

DDDEDNPIYWARYADWLFTTPLLLLHGALLVDADECT 37 AA PAT

ACEQNPIYWARYADWLFTTPLLLLDLALLVDADEGTG 35 AA PAT

ACEQNPIYWARYADWLFTTPLLLLDLALLVDADET 36 AA PAT

ACEQNPIYWARYADWLFTTPLLLLDLALLVDADEGT 38 AA PAT

GGEQNPIYWARYADWLFTTPLLLDLLALLVDADEGTCG 38 AA PAT

GGEQNPIYWARYADWLFTTPLLLLLDALLVDADEGTCG 38 AA PAT

GGEQNPIYWARYAWDLFTTPLLLLDLALLVDADEGTCG 38 AA PAT

AAEQNPIYWARYAEWLFTTPLLLLDLALLVDADEGTCG 38 AA PAT

AAEQNPIYWARYAEWLFTTPLLLLELALLVDADEGTCG 38 AA PAT

GGEQNPIYWARYDAWLFTTPLLLLDLALLVDADEGTCG 38 AA PAT

GGEQNPIYWAQYDAWLFTTPLLLLDLALLVDADEGTCG 38 AA PAT

GGEQNPIYWAQDYAWLFTTPLLLLDLALLVDADEGTCG 38 AA PAT

AAEQNPIYWARYAAWLFTTPLLLLDLALLVDADEGTCG 37 AA PAT

ACEQNPIYWARYANWLFTTPLLLLNLALLVDADEGTG 37 AA PAT

DDDEDNPIYWARYAHWLFTTPLLLLHGALLVNANECT 37 AA PAT

DDDEDNPIYWARYAHWLFTTPLLLLHGALLVNADECT 37 AA PAT

DDDEDNPIYWARYADWLFTTPLLLLHGALLVDADECT 37 AA PAT

DDDEDNPIYWARYAHWLFTTPLLLLHGALLVDADECT 37 AA PAT

DDDEDNPIYWARYAHWLFTTPLLLLDGALLVDADECT 36 AA PAT

GGEQNPIYWARYADWLFTTPLLLLDLALLVNANQGT 38 AA PAT

AAEQNPIYWARYADWLFTTPLLLLELALLVDADEGTCG 38 AA PAT

AAEQNPIYWARYAEWLFTTPLLLLELALLVDADEGTCG 39 AA PAT

AAEQNPIYWARYADWLFTTPLLLLELALLVDADEGTKCG 38 AA PAT

GGEQNPIYWAQYADWLFTTPLLLLDLALLVDADEGTCG 38 AA PAT

GGEQNPIYWAQYDAWLFTTPLLLLDLALLVDADEGTCG 38 AA PAT

GGEQNPIYWAQDYAWLFTTPLLLLDLALLVDADEGTCG 36 AA PAT

GGEQNPIYWARYADWLFTTPLLLLDLALLVNANQGT 37 AA PAT

DDDEDNPIYWARYAHWLFTTPLLLLHGALLVNADECT 37 AA PAT

DDDEDNPIYWARYAHWLFTTPLLLLHGALLVNANECT 37 AA PAT

ACEQNPIYWARYAKWLFTTPLLLLKLALLVDADEGTG 38 AA PAT

GGEQNPIYWAQDYAWLFTTPLLLLDLALLVDADEGTCG 38 AA PAT

GGEQNPIYWAQYDAWLFTTPLLLLDLALLVDADEGTCG 38 AA PAT

GGEQNPIYWAQYADWLFTTPLLLLDLALLVDADEGTCG 38 AA PAT

AAEQNPIYWARYAAWLFTTPLLLLDLALLVDADEGTCG 38 AA PAT

AAEQNPIYWARYADWLFTDLPLLLLDLLALLVDADEGT 38 AA PAT

GGEQNPIYWARYADWLFTTPLLLLLDALLVDADEGTCG 38 AA PAT

GGEQNPIYWARYADWLFTTPLLLDLLALLVDADEGTCG 36 AA PAT

AAEQNPIYWARYADWLFTTGLLLLDLALLVDADEGT 38 AA PAT

AAEQNPIYWARYAAWLFTTPLLLLDLALLVDADEGTCG 38 AA PAT

GGEQNPIYWAQYDAWLFTTPLLLLDLALLVDADEGTCG 38 AA PAT

GGEQNPIYWAQDYAWLFTTPLLLLDLALLVDADEGTCG 38 AA PAT

GGEQNPIYWARYDAWLFTTPLLLLDLALLVDADEGTCG 38 AA PAT

AAEQNPIYWARYADWLFTTPLLLLALALLVDADEGTCG 39 AA PAT

REGION 1..39 note Description of Artificial Sequence: Synthetic polypeptide Descripción de secuencia artificial: Polipéptido sintético MOD_RES 37 note Lys(rhodamine) Lys(rodamina) MOD_RES 38 note Cys(phalloidin) Cys(faloidina) source 1..39 mol_type protein organism synthetic construct construcción sintética

AAEQNPIYWARYADWLFTTPLLLLDLALLVDADEGTKCG 39 AA PAT

AAEQNPIYWARYADWLFTTPLLLLELALLVDADEGTKCG 38 AA PAT

REGION 1..38 note Description of Artificial Sequence: Synthetic polypeptide Descripción de secuencia artificial: Polipéptido sintético MOD_RES 37 note Cys(phalloidin) Cys(faloidina) source 1..38 mol_type protein organism synthetic construct construcción sintética

AAEQNPIYWARYADWLFTTPLLLLDLALLVDADEGTCG 38 AA PAT

GGEQNPIYWARYADWLFTTPLLLLDLALLVDADEGTCG 35 AA PAT

ACEQNPIYWARYADWLFTTPLLLLDLALLVDADET 37 AA PAT

ACEQNPIYWARYADWLFTTPLLLLDLALLVDADEGTG 36 AA PAT

ACEQNPIYWARYADWLFTTPLLLLDLALLVDADEGT 36 AA PAT

GGEQNPIYWARYADWLFTTPLLLLDLALLVNANQGT 37 AA PAT

DDDEDNPIYWARYAHWLFTTPLLLLHGALLVNADECT 37 AA PAT

DDDEDNPIYWARYAHWLFTTPLLLLHGALLVNANECT 38 AA PAT

GGEQNPIYWARYADWLFTTPLLLLDLALLVDADEGTCG 38 AA PAT

AAEQNPIYWARYADWLFTTPLLLLDLALLVDADEGTCG 39 AA PAT

AAEQNPIYWARYADWLFTTPLLLLELALLVDADEGTKCG 39 AA PAT

AAEQNPIYWARYADWLFTTPLLLLDLALLVDADEGTKCG 37 AA PAT

DDDEDNPIYWARYAHWLFTTPLLLLHGALLVDADECT 37 AA PAT

DDDEDNPIYWARYAHWLFTTPLLLLDGALLVDADECT 37 AA PAT

DDDEDNPIYWARYAHWLFTTPLLLLHGALLVNADECT 37 AA PAT

DDDEDNPIYWARYAHWLFTTPLLLLHGALLVNANECT 37 AA PAT

DDDEDNPIYWARYADWLFTTPLLLLHGALLVDADECT 37 AA PAT

DDDEDNPIYWARYAHWLFTTPLLLLDGALLVDADECT 37 AA PAT

DDDEDNPIYWARYAHWLFTTPLLLLHGALLVDADECT 37 AA PAT

DDDEDNPIYWARYAHWLFTTPLLLLHGALLVNADECT 37 AA PAT

DDDEDNPIYWARYAHWLFTTPLLLLHGALLVNANECT 37 AA PAT

DDDEDNPIYWARYAHWLFTTPLLLLHGALLVNADECT 37 AA PAT

DDDEDNPIYWARYADWLFTTPLLLLHGALLVDADECT 37 AA PAT

DDDEDNPIYWARYAHWLFTTPLLLLHGALLVDADECT 37 AA PAT

DDDEDNPIYWARYAHWLFTTPLLLLDGALLVDADECT 36 AA PAT

GGEQNPIYWARYADWLFTTPLLLLDLALLVNANQGT 37 AA PAT

DDDEDNPIYWARYAHWLFTTPLLLLHGALLVNADECT 37 AA PAT

DDDEDNPIYWARYADWLFTTPLLLLHGALLVDADECT 37 AA PAT

DDDEDNPIYWARYAHWLFTTPLLLLHGALLVDADECT 37 AA PAT

DDDEDNPIYWARYAHWLFTTPLLLLDGALLVDADECT 37 AA PAT

DDDEDNPIYWARYAHWLFTTPLLLLHGALLVNANECT 37 AA PAT

DDDEDNPIYWARYAHWLFTTPLLLLDGALLVDADECT 37 AA PAT

DDDEDNPIYWARYADWLFTTPLLLLHGALLVDADECT 37 AA PAT

DDDEDNPIYWARYAHWLFTTPLLLLHGALLVDADECT 37 AA PAT

DDDEDNPIYWARYAHWLFTTPLLLLHGALLVNADECT 37 AA PAT

DDDEDNPIYWARYAHWLFTTPLLLLHGALLVNANECT 36 AA PAT

AAEQNPIYWARYADWLFTTGLLLLDLALLVDADEGT 38 AA PAT

GGEQNPIYWARYAWDLFTTPLLLLDLALLVDADEGTCG 38 AA PAT

GGEQNPIYWARYDAWLFTTPLLLLDLALLVDADEGTCG 38 AA PAT

GGEQNPIYWAQYDAWLFTTPLLLLDLALLVDADEGTCG 38 AA PAT

GGEQNPIYWAQDYAWLFTTPLLLLDLALLVDADEGTCG 38 AA PAT

AAEQNPIYWARYAAWLFTTPLLLLDLALLVDADEGTCG 38 AA PAT

GGEQNPIYWARYADWLFTTPLLLLLDALLVDADEGTCG 38 AA PAT

GGEQNPIYWARYADWLFTTPLLLDLLALLVDADEGTCG 38 AA PAT

GGEQNPIYWARYADWLFTTPLLLLLDALLVDADEGTCG 38 AA PAT

GGEQNPIYWAQYADWLFTTPLLLLDLALLVDADEGTCG 38 AA PAT

GGEQNPIYWAQYDAWLFTTPLLLLDLALLVDADEGTCG 38 AA PAT

GGEQNPIYWAQDYAWLFTTPLLLLDLALLVDADEGTCG 38 AA PAT

GGEQNPIYWAQYDAWLFTTPLLLLDLALLVDADEGTCG 38 AA PAT

GGEQNPIYWAQDYAWLFTTPLLLLDLALLVDADEGTCG 38 AA PAT

GGEQNPIYWAQYADWLFTTPLLLLDLALLVDADEGTCG 38 AA PAT

AAEQNPIYWARYAAWLFTTPLLLLDLALLVDADEGTCG 38 AA PAT

GGEQNPIYWAQDYAWLFTTPLLLLDLALLVDADEGTCG 38 AA PAT

GGEQNPIYWAQYDAWLFTTPLLLLDLALLVDADEGTCG 38 AA PAT

GGEQNPIYWAQYADWLFTTPLLLLDLALLVDADEGTCG 38 AA PAT

AAEQNPIYWARYAAWLFTTPLLLLDLALLVDADEGTCG 39 AA PAT

AAEQNPIYWARYADWLFTTPLLLLELALLVDADEGTKCG 6 AA PAT

REGION 1..6 note Description of Artificial Sequence: Synthetic peptide Descripción de secuencia artificial: péptido sintético MOD_RES 4 note Lys(rhodamine) Lys(rodamina) MOD_RES 5 note Cys(phalloidin) Cys(faloidina) source 1..6 mol_type protein organism synthetic construct construcción sintética

EGTKCG 39 AA PAT

AAEQNPIYWARYADWLFTTPLLLLDLALLVDADEGTKCG 37 AA PAT

ACEQNPIYWARYADWLFTTPLLLLDLALLVDADEGTG 38 AA PAT

AAEQNPIYWARYADWLFTTPLLLLDLALLVDADEGTCG 39 AA PAT

AAEQNPIYWARYADWLFTTPLLLLDLALLVDADEGTKCG 39 AA PAT

AAEQNPIYWARYADWLFTTPLLLLELALLVDADEGTKCG 38 AA PAT

AAEQNPIYWARYADWLFTDLPLLLLDLLALLVDADEGT 38 AA PAT

AAEQNPIYWARYAAWLFTTPLLLLDLALLVDADEGTCG 38 AA PAT

GGEQNPIYWAQYDAWLFTTPLLLLDLALLVDADEGTCG 38 AA PAT

GGEQNPIYWAQDYAWLFTTPLLLLDLALLVDADEGTCG 38 AA PAT

GGEQNPIYWARYDAWLFTTPLLLLDLALLVDADEGTCG 38 AA PAT

AAEQNPIYWARYAEWLFTTPLLLLDLALLVDADEGTCG 38 AA PAT

AAEQNPIYWARYAEWLFTTPLLLLELALLVDADEGTCG 38 AA PAT

AAEQNPIYWARYADWLFTTPLLLLALALLVDADEGTCG 38 AA PAT

AAEQNPIYWARYADWLFTTPLLLLELALLVDADEGTCG 38 AA PAT

AAEQNPIYWARYAEWLFTTPLLLLELALLVDADEGTCG 39 AA PAT

AAEQNPIYWARYADWLFTTPLLLLELALLVDADEGTKCG 37 AA PAT

ACEQNPIYWARYAKWLFTTPLLLLKLALLVDADEGTG 37 AA PAT

ACEQNPIYWARYANWLFTTPLLLLNLALLVDADEGTG 36 AA PAT

AAEQNPIYWARYADWLFTTALLLLDLALLVDADEGT 22 AA PAT

AEQNPIYFARYADLLFPTTLAW 22 AA PAT

AEQNPIYWARYADLLFPTTLAF 22 AA PAT

AEQNPIYWARYADLLFPTTLAW 35 AA PAT

ACEQNPIYWARYADWLFTTPLLLLDLALLVDADET 36 AA PAT

GGEQNPIYWARYADWLFTTPLLLLDLALLVDADEGT 38 AA PAT

AAEQNPIYWARYADWLFTTPLLLLDLALLVDADEGTCG 39 AA PAT

AAEQNPIYWARYADWLFTTPLLLLDLALLVDADEGTKCG 36 AA PAT

AKEQNPIYWARYADWLFTTPLLLLDLALLVDADECT 18 DNA PAT

misc_feature 1..18 note Description of Artificial Sequence: Synthetic oligonucleotide Descripción de secuencia artificial: Oligonucleótido sintético misc_feature 1..18 note Peptide nucleic acid Ácido nucleico peptídico source 1..18 mol_type other DNA organism synthetic construct construcción sintética

cctcttacctcagttaca 18 DNA PAT

cctctgacctcatttaca 18 DNA PAT

cctcttacctcagttaca 18 DNA PAT

cctctgacctcatttaca 18 DNA PAT

cctcttacctcagttaca 38 AA PAT

REGION 1..38 note Description of Unknown: pH-sensitive membrane polypeptide Descripción de desconocido: polipéptido de membrana sensible al pH source 1..38 mol_type protein organism unidentified no identificado

AAEQNPIYWARYADWLFTTPLLLLDLALLVDADEGTCG 31 AA PAT

AEDQNPYWARYDWLFTTPLLLLDLALLVDCG 32 AA PAT

AEDQNPYWARYADWLFTTPLLLLELALLVECG 36 AA PAT

AEQNPIYWARYADWLFTTPLLLLDLALLVDADEGCT 35 AA PAT

ACEQNPIYWARYADWLFTTPLLLLDLALLVDADET 35 AA PAT

AEQNPIYWARYADWLFTTPLLLLDLALLVDADEGT 31 AA PAT

AEDQNPYWARYADWLFTTPLLLLDLALLVDG 31 AA PAT

AEDQNDPYWARYADWLFTTPLLLLDLALLVG 34 AA PAT

AEQNPIYWARYADFLFTTPLLLLDLALLVDADET 34 AA PAT

AEQNPIYFARYADWLFTTPLLLLDLALLVDADET 34 AA PAT

AEQNPIYFARYADFLFTTPLLLLDLALLWDADET 36 AA PAT

AEQNPIYWARYADWLFTTPLLLLDLALLVDADEGCT 34 AA PAT

AEDQNPIYWARYADWLFTTPLLLLDLALLVDCGT 35 AA PAT

AEDQNDPIYWARYADWLFTTPLLLLELALLVECGT 25 AA PAT

ACEEQNPWARYLEWLFPTETLLLEL 35 AA PAT

AEQNPIYWARYADWLFTTPLLLLDLALLVDADEGT 32 AA PAT

AKEDQNPYWARYADWLFTTPLLLLDLALLVDG 32 AA PAT

AKEDQNDPYWARYADWLFTTPLLLLDLALLVG 35 AA PAT

AEQNPIYWARYADWLFTTPLLLLDLALLVDADEGC 31 AA PAT

AEDQNPYWARYADWLFTTPLLLLDLALLVDC 31 AA PAT

AEDQNPYWARYADWLFTTPLLLLELALLVEC 36 AA PAT

ACEQNPIYWARYADWLFTTPLLLLDLALLVDADEGT 32 AA PAT

ACEDQNPYWARYADWLFTTPLLLLDLALLVDG 30 AA PAT

ACEDQNPYWRAYADLFTPLTLLDLLALWDG 27 AA PAT

ACDDQNPWRAYLDLLFPTDTLLLDLLW 27 AA PAT

ACEEQNPWRAYLELLFPTETLLLELLW 25 AA PAT

ACDDQNPWARYLDWLFPTDTLLLDL 24 AA PAT

CDNNNPWRAYLDLLFPTDTLLLDW 25 AA PAT

ACEEQNPWARYLEWLFPTETLLLEL 24 AA PAT

CEEQQPWAQYLELLFPTETLLLEW 24 AA PAT

CEEQQPWRAYLELLFPTETLLLEW 24 AA PAT

ACEDQNPWARYADWLFPTTLLLLD 24 AA PAT

ACEEQNPWARYAEWLFPTTLLLLE 22 AA PAT

ACEDQNPWARYADLLFPTTLAW 22 AA PAT

ACEEQNPWARYAELLFPTTLAW 34 AA PAT

TEDADVLLALDLLLLPTTFLWDAYRAWYPNQECA 37 AA PAT

CDDDDDNPNYWARYANWLFTTPLLLLNGALLVEAEET 37 AA PAT

CDDDDDNPNYWARYAPWLFTTPLLLLPGALLVEAEET 36 AA PAT

AEQNPIYWARYADWLFTTPLLLLDLALLVDADEGCT 37 AA PAT

AKEQNPIYWARYADWLFTTPLLLLDLALLVDADEGTG 36 AA PAT

ACEQNPIYWARYANWLFTTPLLLLNLALLVDADEGT 36 AA PAT

DDDEDNPIYWARYADWLFTTPLLLLHGALLVDADET 36 AA PAT

DDDEDNPIYWARYADWLFTTPLLLLHGALLVDADET 37 AA PAT

CDDDEDNPIYWARYAHWLFTTPLLLLHGALLVDADET 37 AA PAT

DDDEDNPIYWARYAHWLFTTPLLLLHGALLVDADEGT 37 AA PAT

DDDEDNPIYWARYAHWLFTTPLLLLHGALLVNADEGT 37 AA PAT

DDDEDNPIYWARYAHWLFTTPLLLLHGALLVNANEGT 32 AA PAT

AKEDQNDPYWARYADWLFTTPLLLLDLALLVG 31 AA PAT

AEDQNPYWARYADWLFTTPLLLLELALLVCG 28 AA PAT

REGION 1..28 note Description of Artificial Sequence: Synthetic peptide Descripción de secuencia artificial: péptido sintético source 1..28 mol_type protein organism synthetic construct construcción sintética

AKDDQNPWRAYLDLLFPTDTLLLDLLWC 27 AA PAT

ACEEQNPWRAYLELLFPTETLLLELLW 25 AA PAT

ACDDQNPWARYLDWLFPTDTLLLDL 24 AA PAT

CDNNNPWRAYLDLLFPTDTLLLDW 24 AA PAT

CEEQQPWAQYLELLFPTETLLLEW 24 AA PAT

CEEQQPWRAYLELLFPTETLLLEW 37 AA PAT

CDDDDDNPNYWARYANWLFTTPLLLLNGALLVEAEET 36 AA PAT

CDDDDDNPNYWARYAPWLFTTPLLLLPGALLVEAEE 22 AA PAT

AEQNPIYFARYADLLFPTTLAW 22 AA PAT

AEQNPIYWARYADLLFPTTLAF 22 AA PAT

AEQNPIYWARYADLLFPTTLAW 20 AA PAT

KEDQNPWARYADLLFPTTLW 24 AA PAT

ACEEQNPQAEYAEWLFPTTLLLLE 25 AA PAT

AAEEQNPWARYLEWLFPTETLLLEL 25 AA PAT

AKEEQNPWARYLEWLFPTETLLLEL 38 AA PAT

REGION 1..38 note Description of Unknown: Wild-type pH-sensitive membranepolypeptide Descripción de desconocido: polipéptido de membrana sensible al pH de tipo salvaje source 1..38 mol_type protein organism unidentified no identificado

AAEQNPIYWARYADWLFTTPLLLLDLALLVDADEGTGG 38 AA PAT

REGION 1..38 note Description of Artificial Sequence: Synthetic polypeptide Descripción de secuencia artificial: Polipéptido sintético MOD_RES 1 note Ala or Asp Ala o Asp MOD_RES 2 note Ala, Asp or Cys Ala, Asp o Cys MOD_RES 4 note Gln or Asp Gln o Asp MOD_RES 11 note Arg or Gln Arg o Gln MOD_RES 12 note Tyr or Asp Tyr o Asp MOD_RES 13 note Ala, Asp or Tyr Ala, Asp o Tyr MOD_RES 14 note Asp, Asn, Glu, His, Lys, Ala or Trp Asp, Asn, Glu, His, Lys, Ala o Trp MOD_RES 15 note Trp or Asp Trp o Asp MOD_RES 19 note Thr or Asp Thr o Asp MOD_RES 20 note Pro, Gly or Ala Pro, Gly o Ala MOD_RES 24 note Leu or Asp Leu o Asp MOD_RES 25 note Asp, Leu, Asn, Glu, His, Lys or Ala Asp, Leu, Asn, Glu, His, Lys o Ala MOD_RES 26 note Leu, Asp or Gly Leu, Asp o Gly MOD_RES 31 note Asp or Asn Asp o Asn MOD_RES 33 note Asp or Asn Asp o Asn MOD_RES 34 note Glu or Gln Glu o Gln MOD_RES 35 note Gly or Cys Gly o Cys MOD_RES 37 note Gly or Cys Gly o Cys source 1..38 mol_type protein organism synthetic construct construcción sintética

XXEXNPIYWAXXXXXLFTXXLLLXXXALLVXAXXXTXG 42 AA PAT

REGION 1..42 note Description of Artificial Sequence: Synthetic polypeptide Descripción de secuencia artificial: Polipéptido sintético MOD_RES 1 note May or may not be present Puede o no estar presente MOD_RES 21 note May or may not be present Puede o no estar presente MOD_RES 29 note May or may not be present Puede o no estar presente MOD_RES 40 note May or may not be present Puede o no estar presente source 1..42 mol_type protein organism synthetic construct construcción sintética

DAAEQNPIYWARYADWLFTTLPLLLLDLLALLVDADEGTKGG 38 AA PAT

GGEQNPIYWARYADWLFTTPLLLLDLALLVDADEGTGG 38 AA PAT

REGION 1..38 note Description of Artificial Sequence: Synthetic polypeptide Descripción de secuencia artificial: Polipéptido sintético MOD_RES 1 note Gly, Asp or Ala Gly, Asp o Ala MOD_RES 2 note Gly, Asp or Cys Gly, Asp o Cys MOD_RES 4 note Gln or Asp Gln o Asp MOD_RES 11 note Arg or Gln Arg o Gln MOD_RES 12 note Tyr or Asp Tyr o Asp MOD_RES 13 note Ala, Asp or Tyr Ala, Asp o Tyr MOD_RES 14 note Asp, Asn, Glu, His, Lys, Ala or Trp Asp, Asn, Glu, His, Lys, Ala o Trp MOD_RES 15 note Trp or Asp Trp o Asp MOD_RES 19 note Thr or Asp Thr o Asp MOD_RES 20 note Pro, Gly or Ala Pro, Gly o Ala MOD_RES 24 note Leu or Asp Leu o Asp MOD_RES 25 note Asp, Leu, Asn, Glu, His, Lys or Ala Asp, Leu, Asn, Glu, His, Lys o Ala MOD_RES 26 note Leu, Asp or Gly Leu, Asp o Gly MOD_RES 31 note Asp or Asn Asp o Asn MOD_RES 33 note Asp or Asn Asp o Asn MOD_RES 34 note Glu or Gln Glu o Gln MOD_RES 35 note Gly or Cys Gly o Cys source 1..38 mol_type protein organism synthetic construct construcción sintética

XXEXNPIYWAXXXXXLFTXXLLLXXXALLVXAXXXTGG 44 AA PAT

REGION 1..44 note Description of Artificial Sequence: Synthetic polypeptide Descripción de secuencia artificial: Polipéptido sintético MOD_RES 1 note May or may not be present Puede o no estar presente MOD_RES 7 note May or may not be present Puede o no estar presente MOD_RES 22 note May or may not be present Puede o no estar presente MOD_RES 30 note May or may not be present Puede o no estar presente MOD_RES 40 note May or may not be present Puede o no estar presente MOD_RES 42 note Lys, Cys or absent Lys, Cys o ausente source 1..44 mol_type protein organism synthetic construct construcción sintética

DGGEQNDPIYWARYADWLFTTLPLLLLDLLALLVDADEGCTXGG 38 AA PAT

REGION 1..38 note Synthetic polypeptide,which is modified at the CYS, residue 37 ofthe peptide, with a S-S-linker attqached to the nitrogen ofamino-phalloidin Polipéptido sintético, que se modifica en CYS, residuo 37 del péptido, con un enlazador S-S unido al nitrógeno de amino-faloidina source 1..38 mol_type protein organism synthetic construct construcción sintética

AAEQNPIYWARYADWLFTTPLLLLDLALLVDADEGTCG 31 AA PAT

REGION 1..31 note modification of Cys residue 30 with a S-S linker attached to2-amino phalloidin, Lys residue29 modified with an alkyl linkerattached to rhodamine, and Alanine residue 1 modified with aCOCH3 group. modificación de Cys, residuo 30 con un enlazador S-S unido a 2-amino faloidina, Lys, residuo 29, modificado con un alquilo unido a rodamina y Alanina, residuo 1, modificad con un grupo COCH3. source 1..31 mol_type protein organism synthetic construct construcción sintética

AEDQNPYWARYDWLFTTPLLLLDLALLVDCG 34 AA PAT

REGION 1..34 note synthetic peptide péptido sintético source 1..34 mol_type protein organism synthetic construct construcción sintética

GLAGLAGLLGLEGLLGLPLGLLEGLWLGLELEGN