EP P37281-WO EP 21215804.2 2021-12-20 F. Hoffmann-La Roche AG Agonistic LTBR antibodies and bispecific antibodies comprising them Anticuerpos agonistas anti-LTBR y anticuerpos biespecíficos que los comprenden 361 435 AA PAT

source 1..435 mol_type protein organism Homo sapiens Homo sapiens

MLLPWATSAPGLAWGPLVLGLFGLLAASQPQAVPPYASENQTCRDQEKEYYEPQHRICCSRCPPGTYVSAKCSRIRDTVCATCAENSYNEHWNYLTICQLCRPCDPVMGLEEIAPCTSKRKTQCRCQPGMFCAAWALECTHCELLSDCPPGTEAELKDEVGKGNNHCVPCKAGHFQNTSSPSARCQPHTRCENQGLVEAAPGTAQSDTTCKNPLEPLPPEMSGTMLMLAVLLPLAFFLLLATVFSCIWKSHPSLCRKLGSLLKRRPQGEGPNPVAGSWEPPKAHPYFPDLVQPLLPISGDVSPVSTGLPAAPVLEAGVPQQQSPLDLTREPQLEPGEQSQVAHGTNGIHVTGGSMTITGNIYIYNGPVLGGPPGPGDLPATPEPPYPIPEEGDPGPPGLSTPHQEDGKAWHLAETEHCGATPSNRGPRNQFITHD 760 AA PAT

source 1..760 mol_type protein organism Homo sapiens Homo sapiens

MKTWVKIVFGVATSAVLALLVMCIVLRPSRVHNSEENTMRALTLKDILNGTFSYKTFFPNWISGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASNYGLSPDRQFVYLESDYSKLWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITFNGRENKIFNGIPDWVYEEEMLATKYALWWSPNGKFLAYAEFNDTDIPVIAYSYYGDEQYPRTINIPYPKAGAKNPVVRIFIIDTTYPAYVGPQEVPVPAMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDWQTWDCPKTQEHIEESRTGWAGGFFVSTPVFSYDAISYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRVTQDSLFYSSNEFEEYPGRRNIYRISIGSYPPSKKCVTCHLRKERCQYYTASFSDYAKYYALVCYGPGIPISTLHDGRTDQEIKILEENKELENALKNIQLPKEEIKKLEVDEITLWYKMILPPQFDRSKKYPLLIQVYGGPCSQSVRSVFAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASVYTERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLSTNHLYTHMTHFLKQCFSLSD 5 AA PAT

REGION 1..5 note FAP(4B9) CDR-H1 FAP(4B9) CDR-H1 source 1..5 mol_type protein organism synthetic construct construcción sintética

SYAMS 17 AA PAT

REGION 1..17 note FAP(4B9) CDR-H2 FAP(4B9) CDR-H2 source 1..17 mol_type protein organism synthetic construct construcción sintética

AIIGSGASTYYADSVKG 8 AA PAT

REGION 1..8 note FAP(4B9) CDR-H3 FAP(4B9) CDR-H3 source 1..8 mol_type protein organism synthetic construct construcción sintética

GWFGGFNY 12 AA PAT

REGION 1..12 note FAP(4B9) CDR-L1 FAP(4B9) CDR-L1 source 1..12 mol_type protein organism synthetic construct construcción sintética

RASQSVTSSYLA 7 AA PAT

REGION 1..7 note FAP(4B9) CDR-L2 FAP(4B9) CDR-L2 source 1..7 mol_type protein organism synthetic construct construcción sintética

VGSRRAT 9 AA PAT

REGION 1..9 note FAP(4B9) CDR-L3 FAP(4B9) CDR-L3 source 1..9 mol_type protein organism synthetic construct construcción sintética

QQGIMLPPT 117 AA PAT

REGION 1..117 note FAP(4B9) VH FAP(4B9) VH source 1..117 mol_type protein organism synthetic construct construcción sintética

EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSAIIGSGASTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKGWFGGFNYWGQGTLVTVSS 108 AA PAT

REGION 1..108 note FAP(4B9) VL FAP(4B9) VL source 1..108 mol_type protein organism synthetic construct construcción sintética

EIVLTQSPGTLSLSPGERATLSCRASQSVTSSYLAWYQQKPGQAPRLLINVGSRRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQGIMLPPTFGQGTKVEIK 5 AA PAT

REGION 1..5 note FAP (28H1) CDR-H1 FAP (28H1) CDR-H1 source 1..5 mol_type protein organism synthetic construct construcción sintética

SHAMS 16 AA PAT

REGION 1..16 note FAP (28H1) CDR-H2 FAP (28H1) CDR-H2 source 1..16 mol_type protein organism synthetic construct construcción sintética

AIWASGEQYYADSVKG 8 AA PAT

REGION 1..8 note FAP (28H1) CDR-H3 FAP (28H1) CDR-H3 source 1..8 mol_type protein organism synthetic construct construcción sintética

GWLGNFDY 12 AA PAT

REGION 1..12 note FAP (28H1) CDR-L1 FAP (28H1) CDR-L1 source 1..12 mol_type protein organism synthetic construct construcción sintética

RASQSVSRSYLA 7 AA PAT

REGION 1..7 note FAP (28H1) CDR-L2 FAP (28H1) CDR-L2 source 1..7 mol_type protein organism synthetic construct construcción sintética

GASTRAT 9 AA PAT

REGION 1..9 note FAP (28H1) CDR-L3 FAP (28H1) CDR-L3 source 1..9 mol_type protein organism synthetic construct construcción sintética

QQGQVIPPT 116 AA PAT

REGION 1..116 note FAP (28H1) VH FAP (28H1) VH source 1..116 mol_type protein organism synthetic construct construcción sintética

EVQLLESGGGLVQPGGSLRLSCAASGFTFSSHAMSWVRQAPGKGLEWVSAIWASGEQYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKGWLGNFDYWGQGTLVTVSS 108 AA PAT

REGION 1..108 note FAP (28H1) VL FAP (28H1) VL source 1..108 mol_type protein organism synthetic construct construcción sintética

EIVLTQSPGTLSLSPGERATLSCRASQSVSRSYLAWYQQKPGQAPRLLIIGASTRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQGQVIPPTFGQGTKVEIK 5 AA PAT

REGION 1..5 note FAP (1G1a) CDR-H1 FAP (1G1a) CDR-H1 source 1..5 mol_type protein organism synthetic construct construcción sintética

DYNMD 17 AA PAT

REGION 1..17 note FAP (1G1a) CDR-H2 FAP (1G1a) CDR-H2 source 1..17 mol_type protein organism synthetic construct construcción sintética

DIYPNTGGTIYNQKFKG 10 AA PAT

REGION 1..10 note FAP (1G1a) CDR-H3 FAP (1G1a) CDR-H3 source 1..10 mol_type protein organism synthetic construct construcción sintética

FRGIHYAMDY 15 AA PAT

REGION 1..15 note FAP (1G1a) CDR-L1 FAP (1G1a) CDR-L1 source 1..15 mol_type protein organism synthetic construct construcción sintética

RASESVDNYGLSFIN 7 AA PAT

REGION 1..7 note FAP (1G1a) CDR-L2 FAP (1G1a) CDR-L2 source 1..7 mol_type protein organism synthetic construct construcción sintética

GTSNRGS 9 AA PAT

REGION 1..9 note FAP (1G1a) CDR-L3 FAP (1G1a) CDR-L3 source 1..9 mol_type protein organism synthetic construct construcción sintética

QQSNEVPYT 119 AA PAT

REGION 1..119 note FAP (1G1a) VH FAP (1G1a) VH source 1..119 mol_type protein organism synthetic construct construcción sintética

QVQLVQSGAEVKKPGASVKVSCKASGYTLTDYNMDWVRQAPGQGLEWIGDIYPNTGGTIYNQKFKGRVTMTIDTSTSTVYMELSSLRSEDTAVYYCTRFRGIHYAMDYWGQGTTVTVSS 111 AA PAT

REGION 1..111 note FAP (1G1a) VL FAP (1G1a) VL source 1..111 mol_type protein organism synthetic construct construcción sintética

EIVLTQSPATLSLSPGERATLSCRASESVDNYGLSFINWFQQKPGQAPRLLIYGTSNRGSGIPARFSGSGSGTDFTLTISSLEPEDFAVYFCQQSNEVPYTFGGGTKVEIK 5 AA PAT

REGION 1..5 note LTBR (9459) CDR-H1 LTBR (9459) CDR-H1 source 1..5 mol_type protein organism synthetic construct construcción sintética

SYTMN 17 AA PAT

REGION 1..17 note LTBR (9459) CDR-H2 LTBR (9459) CDR-H2 source 1..17 mol_type protein organism synthetic construct construcción sintética

GVAPSGDRTYYTDSVKG 6 AA PAT

REGION 1..6 note LTBR (9459) CDR-H3 LTBR (9459) CDR-H3 source 1..6 mol_type protein organism synthetic construct construcción sintética

GFAFTN 11 AA PAT

REGION 1..11 note LTBR (9459) CDR-L1 LTBR (9459) CDR-L1 source 1..11 mol_type protein organism synthetic construct construcción sintética

RASQGISSALA 7 AA PAT

REGION 1..7 note LTBR (9459) CDR-L2 LTBR (9459) CDR-L2 source 1..7 mol_type protein organism synthetic construct construcción sintética

DASSLDS 9 AA PAT

REGION 1..9 note LTBR (9459) CDR-L3 LTBR (9459) CDR-L3 source 1..9 mol_type protein organism synthetic construct construcción sintética

QQYNNYPLT 115 AA PAT

REGION 1..115 note LTBR (9459) VH LTBR (9459) VH source 1..115 mol_type protein organism synthetic construct construcción sintética

EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYTMNWVRQAPGKGLEWVSGVAPSGDRTYYTDSVKGRFTISRDNAKNTLDLQMTSLRAEDAAIYICAQGFAFTNWGQGTMVTVSS 107 AA PAT

REGION 1..107 note LTBR (9459) VL LTBR (9459) VL source 1..107 mol_type protein organism synthetic construct construcción sintética

DIQMTQSPSSLSASVGDRVTITCRASQGISSALAWFQQKPGKAPKRLIFDASSLDSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNNYPLTFGGGTKVEMK 5 AA PAT

REGION 1..5 note LTBR (9452) CDR-H1 LTBR (9452) CDR-H1 source 1..5 mol_type protein organism synthetic construct construcción sintética

SYPMT 17 AA PAT

REGION 1..17 note LTBR (9452) CDR-H2 LTBR (9452) CDR-H2 source 1..17 mol_type protein organism synthetic construct construcción sintética

LISPSGATTYYADSVKG 19 AA PAT

REGION 1..19 note LTBR (9452) CDR-H3 LTBR (9452) CDR-H3 source 1..19 mol_type protein organism synthetic construct construcción sintética

NHYPDDVIIKNYYFYGVDV 11 AA PAT

REGION 1..11 note LTBR (9452) CDR-L1 LTBR (9452) CDR-L1 source 1..11 mol_type protein organism synthetic construct construcción sintética

RASQDISNYLN 7 AA PAT

REGION 1..7 note LTBR (9452) CDR-L2 LTBR (9452) CDR-L2 source 1..7 mol_type protein organism synthetic construct construcción sintética

AASSLQS 9 AA PAT

REGION 1..9 note LTBR (9452) CDR-L3 LTBR (9452) CDR-L3 source 1..9 mol_type protein organism synthetic construct construcción sintética

QQTHTIPYS 128 AA PAT

REGION 1..128 note LTBR (9452) VH LTBR (9452) VH source 1..128 mol_type protein organism synthetic construct construcción sintética

EVQLLESGGGLVQPGGSLRLSCAAAGFTFSSYPMTWVRQAPGKGLEWVSLISPSGATTYYADSVKGRFTISRDTSKNTLYLQMNSLRAEDTAVYYCAKNHYPDDVIIKNYYFYGVDVWGQGTTVTVSS 107 AA PAT

REGION 1..107 note LTBR (9452) VL LTBR (9452) VL source 1..107 mol_type protein organism synthetic construct construcción sintética

DIQMTQSPSSLSASVGDRVTITCRASQDISNYLNWYQQKPGKAPKSLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFANYYCQQTHTIPYSFGQGTNLEIK 5 AA PAT

REGION 1..5 note LTBR (0080) CDR-H1 LTBR (0080) CDR-H1 source 1..5 mol_type protein organism synthetic construct construcción sintética

YYAMT 16 AA PAT

REGION 1..16 note LTBR (0080) CDR-H2 LTBR (0080) CDR-H2 source 1..16 mol_type protein organism synthetic construct construcción sintética

VINSGGGTYYTDSVKG 6 AA PAT

REGION 1..6 note LTBR (0080) CDR-H3 LTBR (0080) CDR-H3 source 1..6 mol_type protein organism synthetic construct construcción sintética

ASTADV 11 AA PAT

REGION 1..11 note LTBR (0080) CDR-L1 LTBR (0080) CDR-L1 source 1..11 mol_type protein organism synthetic construct construcción sintética

QASQGISNYLS 7 AA PAT

REGION 1..7 note LTBR (0080) CDR-L2 LTBR (0080) CDR-L2 source 1..7 mol_type protein organism synthetic construct construcción sintética

AASSLES 9 AA PAT

REGION 1..9 note LTBR (0080) CDR-L3 LTBR (0080) CDR-L3 source 1..9 mol_type protein organism synthetic construct construcción sintética

QQYNSYSLT 114 AA PAT

REGION 1..114 note LTBR (0080) VH LTBR (0080) VH source 1..114 mol_type protein organism synthetic construct construcción sintética

EVQLLESGGGLVQPGGSLRLSCAASGFTFSYYAMTWVRQAPGKGLEWIGVINSGGGTYYTDSVKGRFTMSRDNSKNTLYLQVNSLRAEDTAVYYCAKASTADVWGQGTTVTVSS 107 AA PAT

REGION 1..107 note LTBR (0080) VL LTBR (0080) VL source 1..107 mol_type protein organism synthetic construct construcción sintética

DIQMTQSPSSLSASVGDRVTITCQASQGISNYLSWYQQKPGKAPKRLIFAASSLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNSYSLTFGGGTKLEIK 5 AA PAT

REGION 1..5 note LTBR (9450) CDR-H1 LTBR (9450) CDR-H1 source 1..5 mol_type protein organism synthetic construct construcción sintética

SYVMK 17 AA PAT

REGION 1..17 note LTBR (9450) CDR-H2 LTBR (9450) CDR-H2 source 1..17 mol_type protein organism synthetic construct construcción sintética

SISGSGGRPFYADSVKG 4 AA PAT

REGION 1..4 note LTBR (9450) CDR-H3 LTBR (9450) CDR-H3 source 1..4 mol_type protein organism synthetic construct construcción sintética

DMDV 11 AA PAT

REGION 1..11 note LTBR (9450) CDR-L1 LTBR (9450) CDR-L1 source 1..11 mol_type protein organism synthetic construct construcción sintética

RASQDISSFLK 7 AA PAT

REGION 1..7 note LTBR (9450) CDR-L2 LTBR (9450) CDR-L2 source 1..7 mol_type protein organism synthetic construct construcción sintética

AASALQS 9 AA PAT

REGION 1..9 note LTBR (9450) CDR-L3 LTBR (9450) CDR-L3 source 1..9 mol_type protein organism synthetic construct construcción sintética

QQYNTYPLT 113 AA PAT

REGION 1..113 note LTBR (9450) VH LTBR (9450) VH source 1..113 mol_type protein organism synthetic construct construcción sintética

EVQLLESGGGLVQPGGSLRLSCAASGFTVSSYVMKWFRQAPGKGLEWVSSISGSGGRPFYADSVKGRFTISRDNSKNALYLQMNSLRAEDTAVYYCANDMDVWGQGTTVTVSS 107 AA PAT

REGION 1..107 note LTBR (9450) VL LTBR (9450) VL source 1..107 mol_type protein organism synthetic construct construcción sintética

DIQMTQSPSSLSASVGDRVTITCRASQDISSFLKWYQQKPGKAPTLLIYAASALQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNTYPLTFGGGTKVDIK 5 AA PAT

REGION 1..5 note LTBR (0079) CDR-H1 LTBR (0079) CDR-H1 source 1..5 mol_type protein organism synthetic construct construcción sintética

SYAMS 17 AA PAT

REGION 1..17 note LTBR (0079) CDR-H2 LTBR (0079) CDR-H2 source 1..17 mol_type protein organism synthetic construct construcción sintética

VITGSSSSIDYADSVKG 14 AA PAT

REGION 1..14 note LTBR (0079) CDR-H3 LTBR (0079) CDR-H3 source 1..14 mol_type protein organism synthetic construct construcción sintética

GGSGVWSISTDFDY 11 AA PAT

REGION 1..11 note LTBR (0079) CDR-L1 LTBR (0079) CDR-L1 source 1..11 mol_type protein organism synthetic construct construcción sintética

QASQDISNYLN 7 AA PAT

REGION 1..7 note LTBR (0079) CDR-L2 LTBR (0079) CDR-L2 source 1..7 mol_type protein organism synthetic construct construcción sintética

AASSLHS 9 AA PAT

REGION 1..9 note LTBR (0079) CDR-L3 LTBR (0079) CDR-L3 source 1..9 mol_type protein organism synthetic construct construcción sintética

QQSHSTPPT 123 AA PAT

REGION 1..123 note LTBR (0079) VH LTBR (0079) VH source 1..123 mol_type protein organism synthetic construct construcción sintética

EVQLLESGGALVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSVITGSSSSIDYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKGGSGVWSISTDFDYWGQGTLVTVSS 107 AA PAT

REGION 1..107 note LTBR (0079) VL LTBR (0079) VL source 1..107 mol_type protein organism synthetic construct construcción sintética

DIQMTQSPSFLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKHLIYAASSLHSGVPSRFSGSGSGAYFTLTITSLQPEDFATYYCQQSHSTPPTFGPGTKVDIK 5 AA PAT

REGION 1..5 note LTBR (9457) CDR-H1 LTBR (9457) CDR-H1 source 1..5 mol_type protein organism synthetic construct construcción sintética

NYAMT 17 AA PAT

REGION 1..17 note LTBR (9457) CDR-H2 LTBR (9457) CDR-H2 source 1..17 mol_type protein organism synthetic construct construcción sintética

EISGSGGSTYYADSVKG 11 AA PAT

REGION 1..11 note LTBR (9457) CDR-H3 LTBR (9457) CDR-H3 source 1..11 mol_type protein organism synthetic construct construcción sintética

DDDGAYGTMDV 11 AA PAT

REGION 1..11 note LTBR (9457) CDR-L1 LTBR (9457) CDR-L1 source 1..11 mol_type protein organism synthetic construct construcción sintética

RASQDISNYLN 7 AA PAT

REGION 1..7 note LTBR (9457) CDR-L2 LTBR (9457) CDR-L2 source 1..7 mol_type protein organism synthetic construct construcción sintética

AASALQS 9 AA PAT

REGION 1..9 note LTBR (9457) CDR-L3 LTBR (9457) CDR-L3 source 1..9 mol_type protein organism synthetic construct construcción sintética

QHYKSYPYT 121 AA PAT

REGION 1..121 note LTBR (9457) VH LTBR (9457) VH source 1..121 mol_type protein organism synthetic construct construcción sintética

EVQLLESGGGLVQPGGSLRLSCAASGFTFSNYAMTWVRQAPGKGLEWVSEISGSGGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKDDDGAYGDTMDVWGQGTTVTVSS 107 AA PAT

REGION 1..107 note LTBR (9457) VL LTBR (9457) VL source 1..107 mol_type protein organism synthetic construct construcción sintética

DIQMTQSPSSLSASIGDRVTITCRASQDISNYLNWYQQKPGKAPKLLIYAASALQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQHYKSYPYTFGQGTKVEIR 5 AA PAT

REGION 1..5 note LTBR (0064) CDR-H1 LTBR (0064) CDR-H1 source 1..5 mol_type protein organism synthetic construct construcción sintética

NTYIH 17 AA PAT

REGION 1..17 note LTBR (0064) CDR-H2 LTBR (0064) CDR-H2 source 1..17 mol_type protein organism synthetic construct construcción sintética

RIDPTNGNTICTEKFKN 11 AA PAT

REGION 1..11 note LTBR (0064) CDR-H3 LTBR (0064) CDR-H3 source 1..11 mol_type protein organism synthetic construct construcción sintética

TTLTTPDSFAY 11 AA PAT

REGION 1..11 note LTBR (0064) CDR-L1 LTBR (0064) CDR-L1 source 1..11 mol_type protein organism synthetic construct construcción sintética

KASQNIYKYLN 7 AA PAT

REGION 1..7 note LTBR (0064) CDR-L2 LTBR (0064) CDR-L2 source 1..7 mol_type protein organism synthetic construct construcción sintética

STNILQT 8 AA PAT

REGION 1..8 note LTBR (0064) CDR-L3 LTBR (0064) CDR-L3 source 1..8 mol_type protein organism synthetic construct construcción sintética

QKYYSGFT 120 AA PAT

REGION 1..120 note LTBR (0064) VH LTBR (0064) VH source 1..120 mol_type protein organism synthetic construct construcción sintética

EVQLQQYGAELGKPGTSVKLSCKVSGYNIGNTYIHWVIQRPGKGLEWIGRIDPTNGNTICTEKFKNKATLTADLSSNTAYMQLSQLKSDDTAIYFCAPTTLTTPDSFAYWGQGTLVTVSS 106 AA PAT

REGION 1..106 note LTBR (0064) VL LTBR (0064) VL source 1..106 mol_type protein organism synthetic construct construcción sintética

DIQMTQSPSQLSASVGDRVTLSCKASQNIYKYLNWYQQKLGEAPRLLIYSTNILQTGIPSRFSGSGSGTDYTLTISSLQPEDAATYFCQKYYSGFTFGSGTKLEMK 5 AA PAT

REGION 1..5 note LTBR (5929) CDR-H1 LTBR (5929) CDR-H1 source 1..5 mol_type protein organism synthetic construct construcción sintética

SYAIS 17 AA PAT

REGION 1..17 note LTBR (5929) CDR-H2 LTBR (5929) CDR-H2 source 1..17 mol_type protein organism synthetic construct construcción sintética

GIIPIFGTANYAQKFQG 11 AA PAT

REGION 1..11 note LTBR (5929) CDR-H3 LTBR (5929) CDR-H3 source 1..11 mol_type protein organism synthetic construct construcción sintética

PSYYLDGWLDY 17 AA PAT

REGION 1..17 note LTBR (5929) CDR-L1 LTBR (5929) CDR-L1 source 1..17 mol_type protein organism synthetic construct construcción sintética

KSSQSVLYSSNNKNYLA 7 AA PAT

REGION 1..7 note LTBR (5929) CDR-L2 LTBR (5929) CDR-L2 source 1..7 mol_type protein organism synthetic construct construcción sintética

WASTRES 9 AA PAT

REGION 1..9 note LTBR (5929) CDR-L3 LTBR (5929) CDR-L3 source 1..9 mol_type protein organism synthetic construct construcción sintética

SQYYTTHYT 120 AA PAT

REGION 1..120 note LTBR (5929) VH LTBR (5929) VH source 1..120 mol_type protein organism synthetic construct construcción sintética

QVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYAISWVRQAPGQGLEWMGGIIPIFGTANYAQKFQGRVTITADKSTSTAYMELSSLRSEDTAVYYCARPSYYLDGWLDYWGQGTTVTVSS 113 AA PAT

REGION 1..113 note LTBR (5929) VL LTBR (5929) VL source 1..113 mol_type protein organism synthetic construct construcción sintética

DIVMTQSPDSLAVSLGERATINCKSSQSVLYSSNNKNYLAWYQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCSQYYTTHYTFGQGTKVEIK 5 AA PAT

REGION 1..5 note LTBR (7213) CDR-H1 LTBR (7213) CDR-H1 source 1..5 mol_type protein organism synthetic construct construcción sintética

SYAIS 17 AA PAT

REGION 1..17 note LTBR (7213) CDR-H2 LTBR (7213) CDR-H2 source 1..17 mol_type protein organism synthetic construct construcción sintética

GIIPIHGTANYAQKFQG 11 AA PAT

REGION 1..11 note LTBR (7213) CDR-H3 LTBR (7213) CDR-H3 source 1..11 mol_type protein organism synthetic construct construcción sintética

PSYYLDGWLDY 17 AA PAT

REGION 1..17 note LTBR (7213) CDR-L1 LTBR (7213) CDR-L1 source 1..17 mol_type protein organism synthetic construct construcción sintética

KSSQSVLYSSNNKNYLA 7 AA PAT

REGION 1..7 note LTBR (7213) CDR-L2 LTBR (7213) CDR-L2 source 1..7 mol_type protein organism synthetic construct construcción sintética

WASTRES 9 AA PAT

REGION 1..9 note LTBR (7213) CDR-L3 LTBR (7213) CDR-L3 source 1..9 mol_type protein organism synthetic construct construcción sintética

SQYYTTHYT 120 AA PAT

REGION 1..120 note LTBR (7213) VH LTBR (7213) VH source 1..120 mol_type protein organism synthetic construct construcción sintética

QVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYAISWVRQAPGQGLEWMGGIIPIHGTANYAQKFQGRVTITADKSTSTAYMELSSLRSEDTAVYYCARPSYYLDGWLDYWGQGTTVTVSS 113 AA PAT

REGION 1..113 note LTBR (7213) VL LTBR (7213) VL source 1..113 mol_type protein organism synthetic construct construcción sintética

DIVMTQSPDSLAVSLGERATINCKSSQSVLYSSNNKNYLAWYQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCSQYYTTHYTFGQGTKVEIK 120 AA PAT

REGION 1..120 note LTBR (CBE11) VH LTBR (CBE11) VH source 1..120 mol_type protein organism synthetic construct construcción sintética

EVQLVESGGGLVKPGGSLRLSCAASGFTFSDYYMYWFRQAPGKGLEWVATISDGGSYTYYPDSVKGRFTISRDNAKNSLYLQMSSLRAEDTAVYYCAREENGNFYYFDYWGQGTTVTVSS 107 AA PAT

REGION 1..107 note LTBR (CBE11) VL LTBR (CBE11) VL source 1..107 mol_type protein organism synthetic construct construcción sintética

DIQMTQSPSSLSASVGDRVTITCKAGQDIKSYLSWYQQKPGKAPKLLIYYATRLADGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCLQHGESPWTFGGGTKLEIK 5 AA PAT

REGION 1..5 note LTBR (CBE11) CDR-H1 LTBR (CBE11) CDR-H1 source 1..5 mol_type protein organism synthetic construct construcción sintética

DYYMY 17 AA PAT

REGION 1..17 note LTBR (CBE11) CDR-H2 LTBR (CBE11) CDR-H2 source 1..17 mol_type protein organism synthetic construct construcción sintética

TISDGGSYTYYPDSVKG 11 AA PAT

REGION 1..11 note LTBR (CBE11) CDR-H3 LTBR (CBE11) CDR-H3 source 1..11 mol_type protein organism synthetic construct construcción sintética

EENGNFYYFDY 11 AA PAT

REGION 1..11 note LTBR (CBE11) CDR-L1 LTBR (CBE11) CDR-L1 source 1..11 mol_type protein organism synthetic construct construcción sintética

KAGQDIKSYLS 7 AA PAT

REGION 1..7 note LTBR (CBE11) CDR-L2 LTBR (CBE11) CDR-L2 source 1..7 mol_type protein organism synthetic construct construcción sintética

YATRLAD 9 AA PAT

REGION 1..9 note LTBR (CBE11) CDR-L3 LTBR (CBE11) CDR-L3 source 1..9 mol_type protein organism synthetic construct construcción sintética

LQHGESPWT 443 AA PAT

REGION 1..443 note P1AF0532 HC knob LTBR crossed P1AF0532 HC botón LTBR cruzado source 1..443 mol_type protein organism synthetic construct construcción sintética

REGION 1..227 note P1AF0532 LC LTBR crossed P1AF0532 LC LTBR cruzado source 1..227 mol_type protein organism synthetic construct construcción sintética

QVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYAISWVRQAPGQGLEWMGGIIPIFGTANYAQKFQGRVTITADKSTSTAYMELSSLRSEDTAVYYCARPSYYLDGWLDYWGQGTTVTVSSASVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 445 AA PAT

REGION 1..445 note P1AF0532 HC hole FAP with charges P1AF0532 HC ojal FAP con cargas source 1..445 mol_type protein organism synthetic construct construcción sintética

EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSAIIGSGASTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKGWFGGFNYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVEDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDEKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSP 215 AA PAT

REGION 1..215 note P1AF0532 LC FAP with charges P1AF0532 LC FAP con cargas source 1..215 mol_type protein organism synthetic construct construcción sintética

EIVLTQSPGTLSLSPGERATLSCRASQSVTSSYLAWYQQKPGQAPRLLINVGSRRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQGIMLPPTFGQGTKVEIKRTVAAPSVFIFPPSDRKLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 448 AA PAT

REGION 1..448 note P1AF9728 HC knob LTBR P1AF9728 HC botón LTBR source 1..448 mol_type protein organism synthetic construct construcción sintética

QVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYAISWVRQAPGQGLEWMGGIIPIHGTANYAQKFQGRVTITADKSTSTAYMELSSLRSEDTAVYYCARPSYYLDGWLDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSP 220 AA PAT

REGION 1..220 note P1AF9728 LC LTBR P1AF9728 LC LTBR source 1..220 mol_type protein organism synthetic construct construcción sintética

DIVMTQSPDSLAVSLGERATINCKSSQSVLYSSNNKNYLAWYQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCSQYYTTHYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 449 AA PAT

REGION 1..449 note P1AF9728 HC hole FAP crossed P1AF9728 HC ojal FAP cruzado source 1..449 mol_type protein organism synthetic construct construcción sintética

EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSAIIGSGASTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKGWFGGFNYWGQGTLVTVSSASVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSP 213 AA PAT

REGION 1..213 note P1AF9728 LC FAP crossed P1AF9728 LC FAP cruzado source 1..213 mol_type protein organism synthetic construct construcción sintética

EIVLTQSPGTLSLSPGERATLSCRASQSVTSSYLAWYQQKPGQAPRLLINVGSRRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQGIMLPPTFGQGTKVEIKSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC 449 AA PAT

REGION 1..449 note P1AG7504 HC knob LTBR P1AG7504 HC botón LTBR source 1..449 mol_type protein organism synthetic construct construcción sintética

REGION 1..220 note P1AG7504 LC LTBR P1AG7504 LC LTBR source 1..220 mol_type protein organism synthetic construct construcción sintética

REGION 1..450 note P1AG7504 HC hole FAP crossed P1AG7504 HC ojal FAP cruzado source 1..450 mol_type protein organism synthetic construct construcción sintética

REGION 1..214 note P1AG7504 LC FAP crossed P1AG7504 LC FAP cruzado source 1..214 mol_type protein organism synthetic construct construcción sintética

REGION 1..437 note P1AF0535 HC knob LTBR crossed P1AF0535 HC botón LTBR cruzado source 1..437 mol_type protein organism synthetic construct construcción sintética

REGION 1..220 note P1AF0535 LC LTBR crossed P1AF0535 LC LTBR cruzado source 1..220 mol_type protein organism synthetic construct construcción sintética

EVQLLESGGGLVQPGGSLRLSCAASGFTVSSYVMKWFRQAPGKGLEWVSSISGSGGRPFYADSVKGRFTISRDNSKNALYLQMNSLRAEDTAVYYCANDMDVWGQGTTVTVSSASVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 445 AA PAT

REGION 1..445 note P1AF0535 HC hole FAP with charges P1AF0535 HC ojal FAP con cargas source 1..445 mol_type protein organism synthetic construct construcción sintética

REGION 1..215 note P1AF0535 LC FAP with charges P1AF0535 LC FAP con cargas source 1..215 mol_type protein organism synthetic construct construcción sintética

REGION 1..438 note P1AG7506 HC knob LTBR crossed P1AG7506 HC botón LTBR cruzado source 1..438 mol_type protein organism synthetic construct construcción sintética

REGION 1..220 note P1AG7506 LC LTBR crossed P1AG7506 LC LTBR cruzado source 1..220 mol_type protein organism synthetic construct construcción sintética

REGION 1..446 note P1AG7506 HC hole FAP charges P1AG7506 HC ojal FAP cargas source 1..446 mol_type protein organism synthetic construct construcción sintética

REGION 1..215 note P1AG7506 LC FAP charges P1AG7506 LC FAP cargas source 1..215 mol_type protein organism synthetic construct construcción sintética

REGION 1..437 note P1AF0534 HC knob LTBR crossed P1AF0534 HC botón LTBR cruzado source 1..437 mol_type protein organism synthetic construct construcción sintética

DIQMTQSPSSLSASVGDRVTITCRASQDISNYLNWYQQKPGKAPKSLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFANYYCQQTHTIPYSFGQGTNLEIKSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSP 235 AA PAT

REGION 1..235 note P1AF0534 LC LTBR crossed P1AF0534 LC LTBR cruzado source 1..235 mol_type protein organism synthetic construct construcción sintética

EVQLLESGGGLVQPGGSLRLSCAAAGFTFSSYPMTWVRQAPGKGLEWVSLISPSGATTYYADSVKGRFTISRDTSKNTLYLQMNSLRAEDTAVYYCAKNHYPDDVIIKNYYFYGVDVWGQGTTVTVSSASVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 445 AA PAT

REGION 1..445 note P1AF0534 HC hole FAP with charges P1AF0534 HC ojal FAP con cargas source 1..445 mol_type protein organism synthetic construct construcción sintética

REGION 1..215 note P1AF0534 LC FAP with charges P1AF0534 LC FAP con cargas source 1..215 mol_type protein organism synthetic construct construcción sintética

REGION 1..438 note P1AG7505 HC knob LTBR crossed P1AG7505 HC botón LTBR cruzado source 1..438 mol_type protein organism synthetic construct construcción sintética

REGION 1..235 note P1AG7505 LC LTBR crossed P1AG7505 LC LTBR cruzado source 1..235 mol_type protein organism synthetic construct construcción sintética

REGION 1..446 note P1AG7505 HC hole FAP charges P1AG7505 HC ojal FAP cargas source 1..446 mol_type protein organism synthetic construct construcción sintética

REGION 1..215 note P1AG7505 LC FAP charges P1AG7505 LC FAP cargas source 1..215 mol_type protein organism synthetic construct construcción sintética

REGION 1..437 note P1AF5257 HC knob LTBR crossed P1AF5257 HC botón LTBR cruzado source 1..437 mol_type protein organism synthetic construct construcción sintética

DIQMTQSPSSLSASIGDRVTITCRASQDISNYLNWYQQKPGKAPKLLIYAASALQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQHYKSYPYTFGQGTKVEIRSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSP 228 AA PAT

REGION 1..228 note P1AF5257 LC LTBR crossed P1AF5257 LC LTBR cruzado source 1..228 mol_type protein organism synthetic construct construcción sintética

EVQLLESGGGLVQPGGSLRLSCAASGFTFSNYAMTWVRQAPGKGLEWVSEISGSGGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKDDDGAYGDTMDVWGQGTTVTVSSASVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 445 AA PAT

REGION 1..445 note P1AF5257 HC hole FAP charges P1AF5257 HC ojal FAP cargas source 1..445 mol_type protein organism synthetic construct construcción sintética

REGION 1..215 note P1AF5257 LC FAP charges P1AF5257 LC FAP cargas source 1..215 mol_type protein organism synthetic construct construcción sintética

REGION 1..437 note P1AF0537 HC knob LTBR crossed P1AF0537 HC botón LTBR cruzado source 1..437 mol_type protein organism synthetic construct construcción sintética

REGION 1..222 note P1AF0537 LC LTBR crossed P1AF0537 LC LTBR cruzado source 1..222 mol_type protein organism synthetic construct construcción sintética

EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYTMNWVRQAPGKGLEWVSGVAPSGDRTYYTDSVKGRFTISRDNAKNTLDLQMTSLRAEDAAIYICAQGFAFTNWGQGTMVTVSSASVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 445 AA PAT

REGION 1..445 note P1AF0537 HC hole FAP with charges P1AF0537 HC ojal FAP con cargas source 1..445 mol_type protein organism synthetic construct construcción sintética

REGION 1..215 note P1AF0537 LC FAP with charges P1AF0537 LC FAP con cargas source 1..215 mol_type protein organism synthetic construct construcción sintética

REGION 1..438 note P1AG7507 HC knob LTBR crossed P1AG7507 HC botón LTBR cruzado source 1..438 mol_type protein organism synthetic construct construcción sintética

REGION 1..222 note P1AG7507 LC LTBR crossed P1AG7507 LC LTBR cruzado source 1..222 mol_type protein organism synthetic construct construcción sintética

REGION 1..446 note P1AG7507 HC hole FAP charges P1AG7507 HC ojal FAP cargas source 1..446 mol_type protein organism synthetic construct construcción sintética

REGION 1..215 note P1AG7507 LC FAP charges P1AG7507 LC FAP cargas source 1..215 mol_type protein organism synthetic construct construcción sintética

REGION 1..448 note P1AG0694 HC knob LTBR P1AG0694 HC botón LTBR source 1..448 mol_type protein organism synthetic construct construcción sintética

QVQLVQSGAEVKKPGASVKVSCKASGYNIGNTYIHWVRQAPGKGLEWMGRIDPTNGNTIYAQKFQGRVTSTRDTSISTAYMELSRLRSDDTVVYYCAPTTLTTPDSFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSP 213 AA PAT

REGION 1..213 note P1AG0694 LC LTBR P1AG0694 LC LTBR source 1..213 mol_type protein organism synthetic construct construcción sintética

DIQMTQSPSSLSASVGDRVTITCRASQNIYKYLNWYQQKPGKAPKLLIYSTNILQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYFCQKYYSGFTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 449 AA PAT

REGION 1..449 note P1AG0694 HC hole FAP crossed P1AG0694 HC ojal FAP cruzado source 1..449 mol_type protein organism synthetic construct construcción sintética

REGION 1..213 note P1AG0694 LC FAP crossed P1AG0694 LC FAP cruzado source 1..213 mol_type protein organism synthetic construct construcción sintética

REGION 1..448 note P1AF9727 HC knob LTBR P1AF9727 HC botón LTBR source 1..448 mol_type protein organism synthetic construct construcción sintética

EVQLQQYGAELGKPGTSVKLSCKVSGYNIGNTYIHWVIQRPGKGLEWIGRIDPTNGNTISTEKFKNKATLTADLSSNTAYMQLSQLKSDDTAIYFCAPTTLTTPDSFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSP 213 AA PAT

REGION 1..213 note P1AF9727 LC LTBR P1AF9727 LC LTBR source 1..213 mol_type protein organism synthetic construct construcción sintética

DIQMTQSPSQLSASVGDRVTLSCKASQNIYKYLNWYQQKLGEAPRLLIYSTNILQTGIPSRFSGSGSGTDYTLTISSLQPEDAATYFCQKYYSGFTFGSGTKLEMKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 449 AA PAT

REGION 1..449 note P1AF9727 HC hole FAP crossed P1AF9727 HC ojal FAP cruzado source 1..449 mol_type protein organism synthetic construct construcción sintética

REGION 1..213 note P1AF9727 LC FAP crossed P1AF9727 LC FAP cruzado source 1..213 mol_type protein organism synthetic construct construcción sintética

REGION 1..437 note P1AF5260 HC knob LTBR crossed P1AF5260 HC botón LTBR cruzado source 1..437 mol_type protein organism synthetic construct construcción sintética

DIQMTQSPSFLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKHLIYAASSLHSGVPSRFSGSGSGAYFTLTITSLQPEDFATYYCQQSHSTPPTFGPGTKVDIKSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSP 230 AA PAT

REGION 1..230 note P1AF5260 LC LTBR crossed P1AF5260 LC LTBR cruzado source 1..230 mol_type protein organism synthetic construct construcción sintética

EVQLLESGGALVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSVITGSSSSIDYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKGGSGVWSISTDFDYWGQGTLVTVSSASVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 445 AA PAT

REGION 1..445 note P1AF5260 HC hole FAP charges P1AF5260 HC ojal FAP cargas source 1..445 mol_type protein organism synthetic construct construcción sintética

REGION 1..215 note P1AF5260 LC FAP charges P1AF5260 LC FAP cargas source 1..215 mol_type protein organism synthetic construct construcción sintética

REGION 1..437 note P1AF5261 HC knob LTBR crossed P1AF5261 HC botón LTBR cruzado source 1..437 mol_type protein organism synthetic construct construcción sintética

REGION 1..221 note P1AF5261 LC LTBR crossed P1AF5261 LC LTBR cruzado source 1..221 mol_type protein organism synthetic construct construcción sintética

EVQLLESGGGLVQPGGSLRLSCAASGFTFSYYAMTWVRQAPGKGLEWIGVINSGGGTYYTDSVKGRFTMSRDNSKNTLYLQVNSLRAEDTAVYYCAKASTADVWGQGTTVTVSSASVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 445 AA PAT

REGION 1..445 note P1AF5261 HC hole FAP charges P1AF5261 HC ojal FAP cargas source 1..445 mol_type protein organism synthetic construct construcción sintética

REGION 1..215 note P1AF5261 LC FAP charges P1AF5261 LC FAP cargas source 1..215 mol_type protein organism synthetic construct construcción sintética

REGION 1..438 note P1AG7508 HC knob LTBR crossed P1AG7508 HC botón LTBR cruzado source 1..438 mol_type protein organism synthetic construct construcción sintética

REGION 1..221 note P1AG7508 LC LTBR crossed P1AG7508 LC LTBR cruzado source 1..221 mol_type protein organism synthetic construct construcción sintética

REGION 1..446 note P1AG7508 HC hole FAP charges P1AG7508 HC ojal FAP cargas source 1..446 mol_type protein organism synthetic construct construcción sintética

REGION 1..215 note P1AG7508 LC FAP charges P1AG7508 LC FAP cargas source 1..215 mol_type protein organism synthetic construct construcción sintética

REGION 1..685 note P1AG5684(2+1) HC knob LTBR - FAP P1AG5684(2+1) HC botón LTBR - FAP source 1..685 mol_type protein organism synthetic construct construcción sintética

DIVMTQSPDSLAVSLGERATINCKSSQSVLYSSNNKNYLAWYQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCSQYYTTHYTFGQGTKVEIKSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSGGGGSGGGGGEVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSAIIGSGASTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKGWFGGFNYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVEDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDEKVEPKSCD 227 AA PAT

REGION 1..227 note P1AG5684(2+1) LC LTBR (2x)crossed P1AG5684(2+1) LC LTBR (2x)cruzado source 1..227 mol_type protein organism synthetic construct construcción sintética

QVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYAISWVRQAPGQGLEWMGGIIPIHGTANYAQKFQGRVTITADKSTSTAYMELSSLRSEDTAVYYCARPSYYLDGWLDYWGQGTTVTVSSASVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 444 AA PAT

REGION 1..444 note P1AG5684(2+1) HC hole LTBR crossed P1AG5684(2+1) HC ojal LTBR cruzado source 1..444 mol_type protein organism synthetic construct construcción sintética

REGION 1..215 note P1AG5684(2+1) LC FAP charges P1AG5684(2+1) LC FAP cargas source 1..215 mol_type protein organism synthetic construct construcción sintética

REGION 1..685 note P1AG7576(2+1) HC knob LTBR - FAP P1AG7576(2+1) HC botón LTBR - FAP source 1..685 mol_type protein organism synthetic construct construcción sintética

DIVMTQSPDSLAVSLGERATINCKSSQSVLYSSNNKNYLAWYQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCSQYYTTHYTFGQGTKVEIKSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSGGGGSGGGGSEVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSAIIGSGASTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKGWFGGFNYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVEDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDEKVEPKSCD 227 AA PAT

REGION 1..227 note P1AG7576(2+1) LC LTBR (2x)crossed P1AG7576(2+1) LC LTBR (2x)cruzado source 1..227 mol_type protein organism synthetic construct construcción sintética

REGION 1..444 note P1AG7576(2+1) HC hole LTBR crossed P1AG7576(2+1) HC ojal LTBR cruzado source 1..444 mol_type protein organism synthetic construct construcción sintética

REGION 1..215 note P1AG7576(2+1) LC FAP charges P1AG7576(2+1) LC FAP cargas source 1..215 mol_type protein organism synthetic construct construcción sintética

REGION 1..684 note P1AG7509(2+1) HC knob LTBR - FAP P1AG7509(2+1) HC botón LTBR - FAP source 1..684 mol_type protein organism synthetic construct construcción sintética

DIVMTQSPDSLAVSLGERATINCKSSQSVLYSSNNKNYLAWYQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCSQYYTTHYTFGQGTKVEIKSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSGGGGSGGGGEVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSAIIGSGASTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKGWFGGFNYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVEDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDEKVEPKSCD 227 AA PAT

REGION 1..227 note P1AG7509(2+1) LC LTBR (2x)crossed P1AG7509(2+1) LC LTBR (2x)cruzado source 1..227 mol_type protein organism synthetic construct construcción sintética

REGION 1..444 note P1AG7509(2+1) HC hole LTBR crossed P1AG7509(2+1) HC ojal LTBR cruzado source 1..444 mol_type protein organism synthetic construct construcción sintética

REGION 1..215 note P1AG7509(2+1) LC FAP charges P1AG7509(2+1) LC FAP cargas source 1..215 mol_type protein organism synthetic construct construcción sintética

REGION 1..679 note P1AF0544(2+1) HC knob LTBR - FAP P1AF0544(2+1) HC botón LTBR - FAP source 1..679 mol_type protein organism synthetic construct construcción sintética

DIQMTQSPSSLSASVGDRVTITCRASQDISSFLKWYQQKPGKAPTLLIYAASALQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNTYPLTFGGGTKVDIKSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSGGGGSGGGGSEVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSAIIGSGASTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKGWFGGFNYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVEDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDEKVEPKSCD 220 AA PAT

REGION 1..220 note P1AF0544(2+1) LC LTBR (2x)crossed P1AF0544(2+1) LC LTBR (2x)cruzado source 1..220 mol_type protein organism synthetic construct construcción sintética

REGION 1..439 note P1AF0544(2+1) HC hole LTBR crossed P1AF0544(2+1) HC ojal LTBR cruzado source 1..439 mol_type protein organism synthetic construct construcción sintética

REGION 1..215 note P1AF0544(2+1) LC FAP charges P1AF0544(2+1) LC FAP cargas source 1..215 mol_type protein organism synthetic construct construcción sintética

REGION 1..678 note P1AG7511(2+1) HC knob LTBR - FAP P1AG7511(2+1) HC botón LTBR - FAP source 1..678 mol_type protein organism synthetic construct construcción sintética

DIQMTQSPSSLSASVGDRVTITCRASQDISSFLKWYQQKPGKAPTLLIYAASALQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNTYPLTFGGGTKVDIKSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSGGGGSGGGGEVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSAIIGSGASTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKGWFGGFNYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVEDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDEKVEPKSCD 220 AA PAT

REGION 1..220 note P1AG7511(2+1) LC LTBR (2x)crossed P1AG7511(2+1) LC LTBR (2x)cruzado source 1..220 mol_type protein organism synthetic construct construcción sintética

REGION 1..438 note P1AG7511(2+1) HC hole LTBR crossed P1AG7511(2+1) HC ojal LTBR cruzado source 1..438 mol_type protein organism synthetic construct construcción sintética

REGION 1..215 note P1AG7511(2+1) LC FAP charges P1AG7511(2+1) LC FAP cargas source 1..215 mol_type protein organism synthetic construct construcción sintética

REGION 1..699 note P1AF9729(2+1) HC knob LTBR (2x) P1AF9729(2+1) HC botón LTBR (2x) source 1..699 mol_type protein organism synthetic construct construcción sintética

EVQLLESGGGLVQPGGSLRLSCAAAGFTFSSYPMTWVRQAPGKGLEWVSLISPSGATTYYADSVKGRFTISRDTSKNTLYLQMNSLRAEDTAVYYCAKNHYPDDVIIKNYYFYGVDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKGGGGSGGGGSEVQLLESGGGLVQPGGSLRLSCAAAGFTFSSYPMTWVRQAPGKGLEWVSLISPSGATTYYADSVKGRFTISRDTSKNTLYLQMNSLRAEDTAVYYCAKNHYPDDVIIKNYYFYGVDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC 214 AA PAT

REGION 1..214 note P1AF9729(2+1) LC LTBR (2x) P1AF9729(2+1) LC LTBR (2x) source 1..214 mol_type protein organism synthetic construct construcción sintética

DIQMTQSPSSLSASVGDRVTITCRASQDISNYLNWYQQKPGKAPKSLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFANYYCQQTHTIPYSFGQGTNLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 449 AA PAT

REGION 1..449 note P1AF9729(2+1) HC hole FAP crossed P1AF9729(2+1) HC ojal FAP cruzado source 1..449 mol_type protein organism synthetic construct construcción sintética

REGION 1..213 note P1AF9729(2+1) LC FAP crossed P1AF9729(2+1) LC FAP cruzado source 1..213 mol_type protein organism synthetic construct construcción sintética

REGION 1..708 note P1AG7510(2+1) HC knob LTBR (2x) P1AG7510(2+1) HC botón LTBR (2x) source 1..708 mol_type protein organism synthetic construct construcción sintética

EVQLLESGGGLVQPGGSLRLSCAAAGFTFSSYPMTWVRQAPGKGLEWVSLISPSGATTYYADSVKGRFTISRDTSKNTLYLQMNSLRAEDTAVYYCAKNHYPDDVIIKNYYFYGVDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSGGGGSGGGGEVQLLESGGGLVQPGGSLRLSCAAAGFTFSSYPMTWVRQAPGKGLEWVSLISPSGATTYYADSVKGRFTISRDTSKNTLYLQMNSLRAEDTAVYYCAKNHYPDDVIIKNYYFYGVDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCD 214 AA PAT

REGION 1..214 note P1AG7510(2+1) LC LTBR (2x) P1AG7510(2+1) LC LTBR (2x) source 1..214 mol_type protein organism synthetic construct construcción sintética

REGION 1..450 note P1AG7510(2+1) HC hole FAP crossed P1AG7510(2+1) HC ojal FAP cruzado source 1..450 mol_type protein organism synthetic construct construcción sintética

REGION 1..214 note P1AG7510(2+1) LC FAP crossed P1AG7510(2+1) LC FAP cruzado source 1..214 mol_type protein organism synthetic construct construcción sintética

REGION 1..679 note P1AF0546(2+1) HC knob LTBR - FAP P1AF0546(2+1) HC botón LTBR - FAP source 1..679 mol_type protein organism synthetic construct construcción sintética

DIQMTQSPSSLSASVGDRVTITCRASQGISSALAWFQQKPGKAPKRLIFDASSLDSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNNYPLTFGGGTKVEMKSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSGGGGSGGGGSEVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSAIIGSGASTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKGWFGGFNYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVEDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDEKVEPKSCD 222 AA PAT

REGION 1..222 note P1AF0546(2+1) LC LTBR (2x)crossed P1AF0546(2+1) LC LTBR (2x)cruzado source 1..222 mol_type protein organism synthetic construct construcción sintética

REGION 1..437 note P1AF0546(2+1) HC hole LTBR crossed P1AF0546(2+1) HC ojal LTBR cruzado source 1..437 mol_type protein organism synthetic construct construcción sintética

REGION 1..215 note P1AF0546(2+1) LC FAP charges P1AF0546(2+1) LC FAP cargas source 1..215 mol_type protein organism synthetic construct construcción sintética

REGION 1..678 note P1AG7512(2+1) HC knob LTBR - FAP P1AG7512(2+1) HC botón LTBR - FAP source 1..678 mol_type protein organism synthetic construct construcción sintética

DIQMTQSPSSLSASVGDRVTITCRASQGISSALAWFQQKPGKAPKRLIFDASSLDSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNNYPLTFGGGTKVEMKSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSGGGGSGGGGEVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSAIIGSGASTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKGWFGGFNYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVEDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDEKVEPKSCD 222 AA PAT

REGION 1..222 note P1AG7512(2+1) LC LTBR (2x)crossed P1AG7512(2+1) LC LTBR (2x)cruzado source 1..222 mol_type protein organism synthetic construct construcción sintética

REGION 1..438 note P1AG7512(2+1) HC hole LTBR crossed P1AG7512(2+1) HC ojal LTBR cruzado source 1..438 mol_type protein organism synthetic construct construcción sintética

REGION 1..215 note P1AG7512(2+1) LC FAP charges P1AG7512(2+1) LC FAP cargas source 1..215 mol_type protein organism synthetic construct construcción sintética

REGION 1..678 note P1AG7513(2+1) HC knob LTBR - FAP P1AG7513(2+1) HC botón LTBR - FAP source 1..678 mol_type protein organism synthetic construct construcción sintética

DIQMTQSPSSLSASVGDRVTITCQASQGISNYLSWYQQKPGKAPKRLIFAASSLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNSYSLTFGGGTKLEIKSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSGGGGSGGGGEVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSAIIGSGASTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKGWFGGFNYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVEDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDEKVEPKSCD 221 AA PAT

REGION 1..221 note P1AG7513(2+1) LC LTBR (2x)crossed P1AG7513(2+1) LC LTBR (2x)cruzado source 1..221 mol_type protein organism synthetic construct construcción sintética

REGION 1..438 note P1AG7513(2+1) HC hole LTBR crossed P1AG7513(2+1) HC ojal LTBR cruzado source 1..438 mol_type protein organism synthetic construct construcción sintética

REGION 1..215 note P1AG7513(2+1) LC FAP charges P1AG7513(2+1) LC FAP cargas source 1..215 mol_type protein organism synthetic construct construcción sintética

REGION 1..679 note P1AG5683(2+1) HC knob LTBR - FAP P1AG5683(2+1) HC botón LTBR - FAP source 1..679 mol_type protein organism synthetic construct construcción sintética

DIQMTQSPSSLSASVGDRVTITCQASQGISNYLSWYQQKPGKAPKRLIFAASSLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNSYSLTFGGGTKLEIKSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSGGGGSGGGGGEVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSAIIGSGASTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKGWFGGFNYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVEDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDEKVEPKSCD 221 AA PAT

REGION 1..221 note P1AG5683(2+1) LC LTBR (2x)crossed P1AG5683(2+1) LC LTBR (2x)cruzado source 1..221 mol_type protein organism synthetic construct construcción sintética

REGION 1..438 note P1AG5683(2+1) HC hole LTBR crossed P1AG5683(2+1) HC ojal LTBR cruzado source 1..438 mol_type protein organism synthetic construct construcción sintética

REGION 1..215 note P1AG5683(2+1) LC FAP charges P1AG5683(2+1) LC FAP cargas source 1..215 mol_type protein organism synthetic construct construcción sintética

REGION 1..679 note P1AG7575(2+1) HC knob LTBR - FAP P1AG7575(2+1) HC botón LTBR - FAP source 1..679 mol_type protein organism synthetic construct construcción sintética

DIQMTQSPSSLSASVGDRVTITCQASQGISNYLSWYQQKPGKAPKRLIFAASSLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNSYSLTFGGGTKLEIKSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSGGGGSGGGGSEVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSAIIGSGASTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKGWFGGFNYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVEDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDEKVEPKSCD 221 AA PAT

REGION 1..221 note P1AG7575(2+1) LC LTBR (2x)crossed P1AG7575(2+1) LC LTBR (2x)cruzado source 1..221 mol_type protein organism synthetic construct construcción sintética

REGION 1..438 note P1AG7575(2+1) HC hole LTBR crossed P1AG7575(2+1) HC ojal LTBR cruzado source 1..438 mol_type protein organism synthetic construct construcción sintética

REGION 1..215 note P1AG7575(2+1) LC FAP charges P1AG7575(2+1) LC FAP cargas source 1..215 mol_type protein organism synthetic construct construcción sintética

REGION 1..437 note P1AG1326 HC knob LTBR crossed P1AG1326 HC botón LTBR cruzado source 1..437 mol_type protein organism synthetic construct construcción sintética

DIQMTQSPSSLSASVGDRVTITCKAGQDIKSYLSWYQQKPGKAPKLLIYYATRLADGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCLQHGESPWTFGGGTKLEIKSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSP 227 AA PAT

REGION 1..227 note P1AG1326 LC LTBR crossed P1AG1326 LC LTBR cruzado source 1..227 mol_type protein organism synthetic construct construcción sintética

EVQLVESGGGLVKPGGSLRLSCAASGFTFSDYYMYWFRQAPGKGLEWVATISDGGSYTYYPDSVKGRFTISRDNAKNSLYLQMSSLRAEDTAVYYCAREENGNFYYFDYWGQGTTVTVSSASVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 445 AA PAT

REGION 1..445 note P1AG1326 HC hole FAP charges P1AG1326 HC ojal FAP cargas source 1..445 mol_type protein organism synthetic construct construcción sintética

REGION 1..215 note P1AG1326 LC FAP charges P1AG1326 LC FAP cargas source 1..215 mol_type protein organism synthetic construct construcción sintética

REGION 1..437 note P1AF4664 HC KK+ LTBR charges (murine 1+1 surrogate) P1AF4664 HC KK+ LTBR cargas (sustituto 1+1 murino) source 1..437 mol_type protein organism synthetic construct construcción sintética

REGION 1..214 note P1AF4664 LC LTBR charges (murine 1+1 surrogate) P1AF4664 LC LTBR cargas (sustituto 1+1 murino) source 1..214 mol_type protein organism synthetic construct construcción sintética

DIQMTQSPSSLSASVGDRVTITCQASQGISNYLSWYQQKPGKAPKRLIFAASSLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNSYSLTFGGGTKLEIKRADAAPTVSIFPPSSRKLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC 433 AA PAT

REGION 1..433 note P1AF4664 HC DD- FAP crossed (murine 1+1 surrogate) P1AF4664 HC DD- FAP cruzado (sustituto 1+1 murino) source 1..433 mol_type protein organism synthetic construct construcción sintética

EIVLTQSPGTLSLSPGERATLSCRASQSVSRSYLAWYQQKPGQAPRLLIIGASTRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQGQVIPPTFGQGTKVEIKSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSQTVTCNVAHPASSTKVDKKIVPRDCGCKPCICTVPEVSSVFIFPPKPKDVLTITLTPKVTCVVVAISKDDPEVQFSWFVDDVEVHTAQTKPREEQINSTFRSVSELPIMHQDWLNGKEFKCRVNSAAFGAPIEKTISKTKGRPKAPQVYTIPPPKEQMAKDKVSLTCMITNFFPEDITVEWQWNGQPAENYDNTQPIMDTDGSYFVYSDLNVQKSNWEAGNTFTCSVLHEGLHNHHTEKSLSHSPG 223 AA PAT

REGION 1..223 note P1AF4664 LC FAP crossed (murine 1+1 surrogate) P1AF4664 LC FAP cruzado (sustituto 1+1 murino) source 1..223 mol_type protein organism synthetic construct construcción sintética

EVQLLESGGGLVQPGGSLRLSCAASGFTFSSHAMSWVRQAPGKGLEWVSAIWASGEQYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKGWLGNFDYWGQGTLVTVSSRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC 680 AA PAT

REGION 1..680 note P1AF4674 HC KK+ LTBR charges - FAP crossed (murine 2+1 surrogate) P1AF4674 HC KK+ LTBR cargas - FAP cruzado (sustituto 2+1 murino) source 1..680 mol_type protein organism synthetic construct construcción sintética

EVQLLESGGGLVQPGGSLRLSCAASGFTFSYYAMTWVRQAPGKGLEWIGVINSGGGTYYTDSVKGRFTMSRDNSKNTLYLQVNSLRAEDTAVYYCAKASTADVWGQGTTVTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVEGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSQTVTCNVAHPASSTKVDEKIVPRDCGCKPCICTVPEVSSVFIFPPKPKDVLTITLTPKVTCVVVAISKDDPEVQFSWFVDDVEVHTAQTKPREEQINSTFRSVSELPIMHQDWLNGKEFKCRVNSAAFGAPIEKTISKTKGRPKAPQVYTIPPPKKQMAKDKVSLTCMITNFFPEDITVEWQWNGQPAENYKNTQPIMKTDGSYFVYSKLNVQKSNWEAGNTFTCSVLHEGLHNHHTEKSLSHSPGGGGGSGGGGSGGGGSGGGGSEVQLLESGGGLVQPGGSLRLSCAASGFTFSSHAMSWVRQAPGKGLEWVSAIWASGEQYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKGWLGNFDYWGQGTLVTVSSRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC 214 AA PAT

REGION 1..214 note P1AF4674 LC LTBR charges (murine 2+1 surrogate) P1AF4674 LC LTBR cargas (sustituto 2+1 murino) source 1..214 mol_type protein organism synthetic construct construcción sintética

REGION 1..437 note P1AF4674 HC DD- LTBR charges (murine 2+1 surrogate) P1AF4674 HC DD- LTBR cargas (sustituto 2+1 murino) source 1..437 mol_type protein organism synthetic construct construcción sintética

REGION 1..212 note P1AF4674 LC FAP crossed (murine 2+1 surrogate) P1AF4674 LC FAP cruzado (sustituto 2+1 murino) source 1..212 mol_type protein organism synthetic construct construcción sintética

REGION 1..448 note P1AE5929 HC (hu IgG1 PG LALA) P1AE5929 HC (IgG1 hu PG LALA) source 1..448 mol_type protein organism synthetic construct construcción sintética

QVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYAISWVRQAPGQGLEWMGGIIPIFGTANYAQKFQGRVTITADKSTSTAYMELSSLRSEDTAVYYCARPSYYLDGWLDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSP 220 AA PAT

REGION 1..220 note P1AE5929 LC (hu IgG1 PG LALA) P1AE5929 LC (IgG1 hu PG LALA) source 1..220 mol_type protein organism synthetic construct construcción sintética

REGION 1..448 note P1AF7213 HC (hu IgG1 PG LALA) P1AF7213 HC (IgG1 hu PG LALA) source 1..448 mol_type protein organism synthetic construct construcción sintética

QVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYAISWVRQAPGQGLEWMGGIIPIHGTANYAQKFQGRVTITADKSTSTAYMELSSLRSEDTAVYYCARPSYYLDGWLDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSP 220 AA PAT

REGION 1..220 note P1AF7213 LC (hu IgG1 PG LALA) P1AF7213 LC (IgG1 hu PG LALA) source 1..220 mol_type protein organism synthetic construct construcción sintética

REGION 1..456 note P1AE9452 HC (hu IgG1 PG LALA) P1AE9452 HC (IgG1 hu PG LALA) source 1..456 mol_type protein organism synthetic construct construcción sintética

REGION 1..214 note P1AE9452 LC (hu IgG1 PG LALA) P1AE9452 LC (IgG1 hu PG LALA) source 1..214 mol_type protein organism synthetic construct construcción sintética

REGION 1..441 note P1AE9450 HC (hu IgG1 PG LALA) P1AE9450 HC (IgG1 hu PG LALA) source 1..441 mol_type protein organism synthetic construct construcción sintética

EVQLLESGGGLVQPGGSLRLSCAASGFTVSSYVMKWFRQAPGKGLEWVSSISGSGGRPFYADSVKGRFTISRDNSKNALYLQMNSLRAEDTAVYYCANDMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSP 214 AA PAT

REGION 1..214 note P1AE9450 LC (hu IgG1 PG LALA) P1AE9450 LC (IgG1 hu PG LALA) source 1..214 mol_type protein organism synthetic construct construcción sintética

DIQMTQSPSSLSASVGDRVTITCRASQDISSFLKWYQQKPGKAPTLLIYAASALQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNTYPLTFGGGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 443 AA PAT

REGION 1..443 note P1AE9459 HC (hu IgG1 PG LALA) P1AE9459 HC (IgG1 hu PG LALA) source 1..443 mol_type protein organism synthetic construct construcción sintética

EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYTMNWVRQAPGKGLEWVSGVAPSGDRTYYTDSVKGRFTISRDNAKNTLDLQMTSLRAEDAAIYICAQGFAFTNWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSP 214 AA PAT

REGION 1..214 note P1AE9459 LC (hu IgG1 PG LALA) P1AE9459 LC (IgG1 hu PG LALA) source 1..214 mol_type protein organism synthetic construct construcción sintética

DIQMTQSPSSLSASVGDRVTITCRASQGISSALAWFQQKPGKAPKRLIFDASSLDSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNNYPLTFGGGTKVEMKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 442 AA PAT

REGION 1..442 note P1AF0080 HC (hu IgG1 PG LALA) P1AF0080 HC (IgG1 hu PG LALA) source 1..442 mol_type protein organism synthetic construct construcción sintética

EVQLLESGGGLVQPGGSLRLSCAASGFTFSYYAMTWVRQAPGKGLEWIGVINSGGGTYYTDSVKGRFTMSRDNSKNTLYLQVNSLRAEDTAVYYCAKASTADVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSP 214 AA PAT

REGION 1..214 note P1AF0080 LC (hu IgG1 PG LALA) P1AF0080 LC (IgG1 hu PG LALA) source 1..214 mol_type protein organism synthetic construct construcción sintética

DIQMTQSPSSLSASVGDRVTITCQASQGISNYLSWYQQKPGKAPKRLIFAASSLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNSYSLTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 448 AA PAT

REGION 1..448 note P1AF0064 HC (hu IgG1 PG LALA) P1AF0064 HC (IgG1 hu PG LALA) source 1..448 mol_type protein organism synthetic construct construcción sintética

EVQLQQYGAELGKPGTSVKLSCKVSGYNIGNTYIHWVIQRPGKGLEWIGRIDPTNGNTICTEKFKNKATLTADLSSNTAYMQLSQLKSDDTAIYFCAPTTLTTPDSFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSP 213 AA PAT

REGION 1..213 note P1AF0064 LC (hu IgG1 PG LALA) P1AF0064 LC (IgG1 hu PG LALA) source 1..213 mol_type protein organism synthetic construct construcción sintética

REGION 1..451 note P1AF0079 HC (hu IgG1 PG LALA) P1AF0079 HC (IgG1 hu PG LALA) source 1..451 mol_type protein organism synthetic construct construcción sintética

EVQLLESGGALVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSVITGSSSSIDYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKGGSGVWSISTDFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSP 214 AA PAT

REGION 1..214 note P1AF0079 LC (hu IgG1 PG LALA) P1AF0079 LC (IgG1 hu PG LALA) source 1..214 mol_type protein organism synthetic construct construcción sintética

DIQMTQSPSFLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKHLIYAASSLHSGVPSRFSGSGSGAYFTLTITSLQPEDFATYYCQQSHSTPPTFGPGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 449 AA PAT

REGION 1..449 note P1AE9457 HC (hu IgG1 PG LALA) P1AE9457 HC (IgG1 hu PG LALA) source 1..449 mol_type protein organism synthetic construct construcción sintética

EVQLLESGGGLVQPGGSLRLSCAASGFTFSNYAMTWVRQAPGKGLEWVSEISGSGGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKDDDGAYGDTMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSP 214 AA PAT

REGION 1..214 note P1AE9457 LC (hu IgG1 PG LALA) P1AE9457 LC (IgG1 hu PG LALA) source 1..214 mol_type protein organism synthetic construct construcción sintética

DIQMTQSPSSLSASIGDRVTITCRASQDISNYLNWYQQKPGKAPKLLIYAASALQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQHYKSYPYTFGQGTKVEIRRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 448 AA PAT

REGION 1..448 note P1AE1873 (CBE11) HC (hu IgG1 PG LALA) P1AE1873 (CBE11) HC (IgG1 hu PG LALA) source 1..448 mol_type protein organism synthetic construct construcción sintética

EVQLVESGGGLVKPGGSLRLSCAASGFTFSDYYMYWFRQAPGKGLEWVATISDGGSYTYYPDSVKGRFTISRDNAKNSLYLQMSSLRAEDTAVYYCAREENGNFYYFDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSP 214 AA PAT

REGION 1..214 note P1AE1873 (CBE11) LC (hu IgG1 PG LALA) P1AE1873 (CBE11) LC (IgG1 hu PG LALA) source 1..214 mol_type protein organism synthetic construct construcción sintética

DIQMTQSPSSLSASVGDRVTITCKAGQDIKSYLSWYQQKPGKAPKLLIYYATRLADGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCLQHGESPWTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 242 AA PAT

REGION 1..242 note Fc-depleter kh NC avi B (P1AA0981) (knob chain) agotador Fc kh NC avi B (P1AA0981) (cadena botón) source 1..242 mol_type protein organism synthetic construct construcción sintética

GLNDIFEAQKIEWHEDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 244 AA PAT

REGION 1..244 note Fc-depleter kh NC avi B P1AA0981) (hole chain) agotador Fc kh NC avi B P1AA0981) (cadena ojal) source 1..244 mol_type protein organism synthetic construct construcción sintética

DKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKSGGLNDIFEAQKIEWHE 492 AA PAT

REGION 1..492 note human lymphotoxin alpha/beta single-chain avi his (P1AE1235) linfotoxina alfa/beta humana monocatenaria avi his (P1AE1235) source 1..492 mol_type protein organism synthetic construct construcción sintética

KPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSGKAYSPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQLSTHTDGIPHLVLSPSTVFFGAFALGGSGLPAAHLIGAPLKGQGLGWETTKEQAFLTSGTQFSDAEGLALPQDGLYYLYCLVGYRGRAPPGGGDPQGRSVTLRSSLYRAGGAYGPGTPELLLEGAETVTPVLDPARRQGYGPLWYTSVGFGGLVQLRRGERVYVNISHPDMVDFARGKTFFGAVMVGGSGLPAAHLIGAPLKGQGLGWETTKEQAFLTSGTQFSDAEGLALPQDGLYYLYCLVGYRGRAPPGGGDPQGRSVTLRSSLYRAGGAYGPGTPELLLEGAETVTPVLDPARRQGYGPLWYTSVGFGGLVQLRRGERVYVNISHPDMVDFARGKTFFGAVMVGGSGLNDIFEAQKIEWHEGGHHHHHH 484 AA PAT

REGION 1..484 note murine lymphotoxin alpha/beta single-chain avi his (P1AE1236) linfotoxina alfa/beta murina monocatenaria avi his (P1AE1236) source 1..484 mol_type protein organism synthetic construct construcción sintética

KPAAHLVGYPSKQNSLLWRASTDRAFLRHGFSLSNNSLLIPTSGLYFVYSQVVFSGESCSPRAIPTPIYLAHEVQLFSSQYPFHVPLLSAQKSVYPGLQGPWVRSMYQGAVFLLSKGDQLSTHTDGISHLHFSPSSVFFGAFALGGSGLPAAHLIGAWMSGQGLSWEASQEEAFLRSGAQFSPTHGLALPQDGVYYLYCHVGYRGRTPPAGRSRARSLTLRSALYRAGGAYGRGSPELLLEGAETVTPVVDPIGYGSLWYTSVGFGGLAQLRSGERVYVNISHPDMVDYRRGKTFFGAVMVGGSGLPAAHLIGAWMSGQGLSWEASQEEAFLRSGAQFSPTHGLALPQDGVYYLYCHVGYRGRTPPAGRSRARSLTLRSALYRAGGAYGRGSPELLLEGAETVTPVVDPIGYGSLWYTSVGFGGLAQLRSGERVYVNISHPDMVDYRRGKTFFGAVMVGGSGLNDIFEAQKIEWHEGGHHHHHH 448 AA PAT

REGION 1..448 note monomeric huLTBR ECD (S28-M227) Fc-fusion avi biotinylated (P1AE2835) (knob chain) fusión Fc DEC LTBRhu monomérico (S28-M227) avi biotinilado (P1AE2835) (cadena botón) source 1..448 mol_type protein organism synthetic construct construcción sintética

SQPQAVPPYASENQTCRDQEKEYYEPQHRICCSRCPPGTYVSAKCSRIRDTVCATCAENSYNEHWNYLTICQLCRPCDPVMGLEEIAPCTSKRKTQCRCQPGMFCAAWALECTHCELLSDCPPGTEAELKDEVGKGNNHCVPCKAGHFQNTSSPSARCQPHTRCENQGLVEAAPGTAQSDTTCKNPLEPLPPEMSGTMLMASGSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKSGGLNDIFEAQKIEWHE 227 AA PAT

REGION 1..227 note monomeric huLTBR ECD (S28-M227) Fc-fusion avi biotinylated (P1AE2835) (hole chain) fusión Fc DEC LTBRhu monomérico (S28-M227) avi biotinilado (P1AE2835) (cadena ojal) source 1..227 mol_type protein organism synthetic construct construcción sintética

REGION 1..444 note monomeric muLTBR ECD (S28-L223) Fc-fusion avi biotinylated (P1AE4410) (knob chain) fusión Fc DEC LTBRmu monomérico (S28-L223) avi biotinilado (P1AE4410) (cadena botón) source 1..444 mol_type protein organism synthetic construct construcción sintética

SQPQLVPPYRIENQTCWDQDKEYYEPMHDVCCSRCPPGEFVFAVCSRSQDTVCKTCPHNSYNEHWNHLSTCQLCRPCDIVLGFEEVAPCTSDRKAECRCQPGMSCVYLDNECVHCEEERLVLCQPGTEAEVTDEIMDTDVNCVPCKPGHFQNTSSPRARCQPHTRCEIQGLVEAAPGTSYSDTICKNPPEPGAMLLASGSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKSGGLNDIFEAQKIEWHE 227 AA PAT

REGION 1..227 note monomeric muLTBR ECD (S28-L223) Fc-fusion avi biotinylated (P1AE4410)(hole chain) fusión Fc DEC LTBRmu monomérico (S28-L223) avi biotinilado (P1AE4410)(cadena ojal) source 1..227 mol_type protein organism synthetic construct construcción sintética

REGION 1..448 note monomeric cynoLTBR ectodomain (S28-M227) Fc fusion avi biotinylated (P1AE4411) (knob chain) fusión Fc ectodominio LTBRcyno monomérico (S28-M227) avi biotinilado (P1AE4411) (cadena botón) source 1..448 mol_type protein organism synthetic construct construcción sintética

SQPQVVPPYGSENQTCRDQEKEYYEPRHRICCSRCPPGTYVSAKCSRSRDTVCATCAENSYNEHWNYLTICQLCRPCDPVMGLEEIAPCTSKRKTQCRCQPGMFCAAWALECTHCELLSDCPPGTEAELKDEVGKGNNHCVPCKAGHFQNTSSPSARCQPHTRCEDQGLVEAAPGTAQSDTTCRNPSESLPPEMSGTMLMASGSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKSGGLNDIFEAQKIEWHE 227 AA PAT

REGION 1..227 note monomeric cynoLTBR ectodomain (S28-M227) Fc fusion avi biotinylated (P1AE4411) (hole chain) fusión Fc ectodominio LTBRcyno monomérico (S28-M227) avi biotinilado (P1AE4411) (cadena ojal) source 1..227 mol_type protein organism synthetic construct construcción sintética

REGION 1..419 note monomeric N-terminal human LTbR (ECD full length) hu IgG1 Fc-fusion kih HRYF avi (P1AE1217)(knob chain) fusión Fc LTbR humano N-terminal monomérico (DEC longitud completa) IgG1 hu kih HRYF avi (P1AE1217)(cadena botón) source 1..419 mol_type protein organism synthetic construct construcción sintética

QTCRDQEKEYYEPQHRICCSRCPPGTYVSAKCSRIRDTVCATCAENSYNEHWNYLTICQLCRPCDPVMGLEEIAPCTSKRKTQCRCQPGMFCAAWALECTHCELLSDCPPGTEAELKDEVGKGNNHCVPCKAGHFQNTSSPSARCQPHTRCENQGLVEAAPGTAQSDTTCKASGSDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKSGGLNDIFEAQKIEWHE 227 AA PAT

REGION 1..227 note monomeric N-terminal human LTbR (ECD full length) hu IgG1 Fc-fusion kih HRYF avi (P1AE1217)(hole chain) fusión Fc LTbR humano N-terminal monomérico (DEC longitud completa) IgG1 hu kih HRYF avi (P1AE1217)(cadena ojal) source 1..227 mol_type protein organism synthetic construct construcción sintética

REGION 1..15 note Avi tag Etiqueta Avi source 1..15 mol_type protein organism synthetic construct construcción sintética

GLNDIFEAQKIEWHE 456 AA PAT

REGION 1..456 note human LTBR ECD (S28-M227) N- and C-terminally extended - Fc-fusion wt kih HRYF - Avi - His biotinylated 261(P1AE7979)(knob chain) fusión Fc DEC LTBR humano (S28-M227) extendido N y C terminal - natural HRYF - Avi - His biotinilado 261(P1AE7979)(cadena botón) source 1..456 mol_type protein organism synthetic construct construcción sintética

REGION 1..227 note human LTBR ECD (S28-M227) N- and C-terminally extended - Fc-fusion wt kih HRYF - Avi - His biotinylated (P1AE7979)(hole chain) fusión Fc DEC LTBR humano (S28-M227) extendido N y C terminal - natural HRYF - Avi - His biotinilado (P1AE7979)(cadena ojal) source 1..227 mol_type protein organism synthetic construct construcción sintética

REGION 1..419 note monomeric N-terminal cyno LTbR (ECD full length) hu IgG1 Fc-fusion kih HRYF avi biotinylated (P1AE2656)(knob chain) fusión Fc LTbR cyno N-terminal monomérico (DEC longitud completa) IgG1 hu kih HRYF avi (P1AE2656)(cadena botón) source 1..419 mol_type protein organism synthetic construct construcción sintética

QTCRDQEKEYYEPRHRICCSRCPPGTYVSAKCSRSRDTVCATCAENSYNEHWNYLTICQLCRPCDPVMGLEEIAPCTSKRKTQCRCQPGMFCAAWALECTHCELLSDCPPGTEAELKDEVGKGNNHCVPCKAGHFQNTSSPSARCQPHTRCEDQGLVEAAPGTAQSDTTCRASGSDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALGAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKSGGLNDIFEAQKIEWHE 227 AA PAT

REGION 1..227 note monomeric N-terminal cyno LTbR (ECD full length) hu IgG1 Fc-fusion kih HRYF avi biotinylated (P1AE2656)(hole chain) fusión Fc LTbR cyno N-terminal monomérico (DEC longitud completa) IgG1 hu kih HRYF avi (P1AE2656)(cadena ojal) source 1..227 mol_type protein organism synthetic construct construcción sintética

REGION 1..768 note human FAP - Avi - His biotinylated (P1AA5347) FAP humana - Avi - His biotinilado (P1AA5347) source 1..768 mol_type protein organism synthetic construct construcción sintética

RPSRVHNSEENTMRALTLKDILNGTFSYKTFFPNWISGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASNYGLSPDRQFVYLESDYSKLWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITFNGRENKIFNGIPDWVYEEEMLATKYALWWSPNGKFLAYAEFNDTDIPVIAYSYYGDEQYPRTINIPYPKAGAKNPVVRIFIIDTTYPAYVGPQEVPVPAMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDWQTWDCPKTQEHIEESRTGWAGGFFVSTPVFSYDAISYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRVTQDSLFYSSNEFEEYPGRRNIYRISIGSYPPSKKCVTCHLRKERCQYYTASFSDYAKYYALVCYGPGIPISTLHDGRTDQEIKILEENKELENALKNIQLPKEEIKKLEVDEITLWYKMILPPQFDRSKKYPLLIQVYGGPCSQSVRSVFAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASVYTERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLSTNHLYTHMTHFLKQCFSLSVDEQLYFQGGSGLNDIFEAQKIEWHEARAHHHHHH 770 AA PAT

REGION 1..770 note murine FAP - Avi - His biotinylated (P1AD9907) FAP murina - Avi - His biotinilado (P1AD9907) source 1..770 mol_type protein organism synthetic construct construcción sintética

RPSRVYKPEGNTKRALTLKDILNGTFSYKTYFPNWISEQEYLHQSEDDNIVFYNIETRESYIILSNSTMKSVNATDYGLSPDRQFVYLESDYSKLWRYSYTATYYIYDLQNGEFVRGYELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITYTGRENRIFNGIPDWVYEEEMLATKYALWWSPDGKFLAYVEFNDSDIPIIAYSYYGDGQYPRTINIPYPKAGAKNPVVRVFIVDTTYPHHVGPMEVPVPEMIASSDYYFSWLTWVSSERVCLQWLKRVQNVSVLSICDFREDWHAWECPKNQEHVEESRTGWAGGFFVSTPAFSQDATSYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAIYIFRVTQDSLFYSSNEFEGYPGRRNIYRISIGNSPPSKKCVTCHLRKERCQYYTASFSYKAKYYALVCYGPGLPISTLHDGRTDQEIQVLEENKELENSLRNIQLPKVEIKKLKDGGLTFWYKMILPPQFDRSKKYPLLIQVYGGPCSQSVKSVFAVNWITYLASKEGIVIALVDGRGTAFQGDKFLHAVYRKLGVYEVEDQLTAVRKFIEMGFIDEERIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASIYSERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGILSGRSQNHLYTHMTHFLKQCFSLSDVDEQLYFQGGSGLNDIFEAQKIEWHEARAHHHHHH 5 AA PAT

REGION 1..5 note LTBR (5929) CDR-H2 patch parche CDR-H2 LTBR (5929) source 1..5 mol_type protein organism synthetic construct construcción sintética

IPIFG 40 DNA PAT

misc_feature 1..40 note HUJH5.HFc-DO3 HUJH5.HFc-DO3 source 1..40 mol_type other DNA organism synthetic construct construcción sintética

cttgggcccttggtacttgctgaggagacggtgaccaggg 40 DNA PAT

misc_feature 1..40 note HUJH6.HFc-Do3 HUJH6.HFc-Do3 source 1..40 mol_type other DNA organism synthetic construct construcción sintética

cttgggcccttggtacttgctgaggagacggtgaccgtgg 42 DNA PAT

misc_feature 1..42 note BcPCR_FHLC_leader.fw (TG) BcPCR_FHLC_líder.fw (TG) source 1..42 mol_type other DNA organism synthetic construct construcción sintética

acagaggaagcttgccgccaccatggacatgagggtccccgc 24 DNA PAT

misc_feature 1..24 note HuCK.Do.2AA HuCK.Do.2AA source 1..24 mol_type other DNA organism synthetic construct construcción sintética

tgaagacagatggtgcagccacag 26 DNA PAT

misc_feature 1..26 note WTRat.VH.FW11 WTRat.VH.FW11 source 1..26 mol_type other DNA organism synthetic construct construcción sintética

sargtvmagctgvwgsagtcwggrss 26 DNA PAT

misc_feature 1..26 note WTRat.VH.FW12 WTRat.VH.FW12 source 1..26 mol_type other DNA organism synthetic construct construcción sintética

saggtgmagctsswgsarwcwggrss 26 DNA PAT

misc_feature 1..26 note WTRat.VH.FW13 WTRat.VH.FW13 source 1..26 mol_type other DNA organism synthetic construct construcción sintética

sargtkmarctgswgsagtcwggrss 26 DNA PAT

misc_feature 1..26 note WTRat.VH.FW14 WTRat.VH.FW14 source 1..26 mol_type other DNA organism synthetic construct construcción sintética

smggtgmagctkswksagtcwggwss 26 DNA PAT

misc_feature 1..26 note WTRat.VH.FW15 WTRat.VH.FW15 source 1..26 mol_type other DNA organism synthetic construct construcción sintética

aggtkmmkctgawrsartcwggmsst 26 DNA PAT

misc_feature 1..26 note WTRat.VH.FW16 WTRat.VH.FW16 source 1..26 mol_type other DNA organism synthetic construct construcción sintética

saggtrmagctgvwrsagtcwggrsv 26 DNA PAT

misc_feature 1..26 note WTRat.VH.FW17 WTRat.VH.FW17 source 1..26 mol_type other DNA organism synthetic construct construcción sintética

aggtgcagctdvwrsagwcwggrssw 19 DNA PAT

misc_feature 1..19 note 682.rev do 682.rev do source 1..19 mol_type other DNA organism synthetic construct construcción sintética

gggaagatgaagacagatg 25 DNA PAT

misc_feature 1..25 note WTRat.VK.FW1 WTRat.VK.FW1 source 1..25 mol_type other DNA organism synthetic construct construcción sintética

gryrtyswgwtgacmcardctccdb 25 DNA PAT

misc_feature 1..25 note WTRat.VK.FW2 WTRat.VK.FW2 misc_feature 15 note n is a, c, g, or t n es a, c, g o t source 1..25 mol_type other DNA organism synthetic construct construcción sintética

gmtrttgtkmtsamncardcwccab 29 DNA PAT

misc_feature 1..29 note WTRat.CKappa.Do2 WTRat.CKappa.Do2 source 1..29 mol_type other DNA organism synthetic construct construcción sintética

gacgggtgaggatgatgtcttatgaacaa 761 AA PAT

source 1..761 mol_type protein organism Mus musculus Mus musculus

MKTWLKTVFGVTTLAALALVVICIVLRPSRVYKPEGNTKRALTLKDILNGTFSYKTYFPNWISEQEYLHQSEDDNIVFYNIETRESYIILSNSTMKSVNATDYGLSPDRQFVYLESDYSKLWRYSYTATYYIYDLQNGEFVRGYELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITYTGRENRIFNGIPDWVYEEEMLATKYALWWSPDGKFLAYVEFNDSDIPIIAYSYYGDGQYPRTINIPYPKAGAKNPVVRVFIVDTTYPHHVGPMEVPVPEMIASSDYYFSWLTWVSSERVCLQWLKRVQNVSVLSICDFREDWHAWECPKNQEHVEESRTGWAGGFFVSTPAFSQDATSYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAIYIFRVTQDSLFYSSNEFEGYPGRRNIYRISIGNSPPSKKCVTCHLRKERCQYYTASFSYKAKYYALVCYGPGLPISTLHDGRTDQEIQVLEENKELENSLRNIQLPKVEIKKLKDGGLTFWYKMILPPQFDRSKKYPLLIQVYGGPCSQSVKSVFAVNWITYLASKEGIVIALVDGRGTAFQGDKFLHAVYRKLGVYEVEDQLTAVRKFIEMGFIDEERIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASIYSERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGISSGRSQNHLYTHMTHFLKQCFSLSD 98 AA PAT

source 1..98 mol_type protein organism Homo sapiens Homo sapiens

ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKV 5 AA PAT

source 1..5 mol_type protein organism Homo sapiens Homo sapiens

EPKSC 6 AA PAT

source 1..6 mol_type protein organism synthetic construct construcción sintética REGION 1..6 note CH1 connector C-terminal end D-variant variante D extremo C terminal conector CH1

EPKSCD 6 AA PAT

source 1..6 mol_type protein organism synthetic construct construcción sintética REGION 1..6 note CH1 connector C-terminal end S-variant variante S extremo C terminal conector CH1

EPKSCS 10 AA PAT

REGION 1..10 note MISC_FEATURE - X being S or P MISC_FEATURE - X es S o P SITE 8 note misc_feature - X can be any naturally occurring amino acid misc_feature - X puede ser cualquier aminoácido natural source 1..10 mol_type protein organism synthetic construct construcción sintética

DKTHTCPXCP 7 AA PAT

REGION 1..7 note MISC_FEATURE - X being S or P MISC_FEATURE - X es S o P SITE 5 note misc_feature - X can be any naturally occurring amino acid misc_feature - X puede ser cualquier aminoácido natural source 1..7 mol_type protein organism synthetic construct construcción sintética

HTCPXCP 5 AA PAT

REGION 1..5 note MISC_FEATURE - X being S or P MISC_FEATURE - X es S o P SITE 3 note misc_feature - X can be any naturally occurring amino acid misc_feature - X puede ser cualquier aminoácido natural source 1..5 mol_type protein organism synthetic construct construcción sintética

CPXCP 107 AA PAT

source 1..107 mol_type protein organism Homo sapiens Homo sapiens

APELLGGPSVFLFPPKPKDTLMISRTPEVTCVWDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQESTYRWSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAK 105 AA PAT

source 1..105 mol_type protein organism Homo sapiens Homo sapiens

GQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSP 330 AA PAT

source 1..330 mol_type protein organism Homo sapiens Homo sapiens

ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 330 AA PAT

source 1..330 mol_type protein organism Homo sapiens Homo sapiens

ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 326 AA PAT

source 1..326 mol_type protein organism Homo sapiens Homo sapiens

ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDISVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 377 AA PAT

source 1..377 mol_type protein organism Homo sapiens Homo sapiens

ASTKGPSVFPLAPCSRSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYTCNVNHKPSNTKVDKRVELKTPLGDTTHTCPRCPEPKSCDTPPPCPRCPEPKSCDTPPPCPRCPEPKSCDTPPPCPRCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFKWYVDGVEVHNAKTKPREEQYNSTFRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESSGQPENNYNTTPPMLDSDGSFFLYSKLTVDKSRWQQGNIFSCSVMHEALHNRFTQKSLSLSPGK 327 AA PAT

source 1..327 mol_type protein organism Homo sapiens Homo sapiens

ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPSCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK 415 AA PAT

source 1..415 mol_type protein organism Mus musculus Mus musculus

MRLPRASSPCGLAWGPLLLGLSGLLVASQPQLVPPYRIENQTCWDQDKEYYEPMHDVCCSRCPPGEFVFAVCSRSQDTVCKTCPHNSYNEHWNHLSTCQLCRPCDIVLGFEEVAPCTSDRKAECRCQPGMSCVYLDNECVHCEEERLVLCQPGTEAEVTDEIMDTDVNCVPCKPGHFQNTSSPRARCQPHTRCEIQGLVEAAPGTSYSDTICKNPPEPGAMLLLAILLSLVLFLLFTTVLACAWMRHPSLCRKLGTLLKRHPEGEESPPCPAPRADPHFPDLAEPLLPMSGDLSPSPAGPPTAPSLEEVVLQQQSPLVQARELEAEPGEHGQVAHGANGIHVTGGSVTVTGNIYIYNGPVLGGTRGPGDPPAPPEPPYPTPEEGAPGPSELSTPYQEDGKAWHLAETETLGCQDL 5 AA PAT

REGION 1..5 note Peptide linker (G4S) Conector peptídico (G4S) source 1..5 mol_type protein organism synthetic construct construcción sintética

GGGGS 10 AA PAT

REGION 1..10 note Peptide linker (G4S)2 Conector peptídico (G4S)2 source 1..10 mol_type protein organism synthetic construct construcción sintética

GGGGSGGGGS 10 AA PAT

REGION 1..10 note Peptide linker (SG4)2 Conector peptídico (SG4)2 source 1..10 mol_type protein organism synthetic construct construcción sintética

SGGGGSGGGG 14 AA PAT

REGION 1..14 note Peptide linker G4(SG4)2 Conector peptídico G4(SG4)2 source 1..14 mol_type protein organism synthetic construct construcción sintética

GGGGSGGGGSGGGG 10 AA PAT

REGION 1..10 note peptide linker conector peptídico source 1..10 mol_type protein organism synthetic construct construcción sintética

GSPGSSSSGS 15 AA PAT

REGION 1..15 note (G4S)3 peptide linker Conector peptídico (G4S)3 source 1..15 mol_type protein organism synthetic construct construcción sintética

GGGGSGGGGSGGGGS 20 AA PAT

REGION 1..20 note (G4S)4 peptide linker Conector peptídico (G4S)4 source 1..20 mol_type protein organism synthetic construct construcción sintética

GGGGSGGGGSGGGGSGGGGS 8 AA PAT