Sequence Listing Information: DTD Version: V1_3 File Name: 01183-0210-00PCT-KAD.xml Software Name: WIPO Sequence Software Version: 2.2.0 Production Date: 2022-11-27 General Information: Current application / Applicant file reference: 01183-0210-00PCT-KAD Earliest priority application / IP Office: US Earliest priority application / Application number: US 63/284,937 Earliest priority application / Filing date: 2021-12-01 Applicant name: KADMON CORPORATION, LLC Applicant name / Language: en Inventor name: LU, Dan et al. Inventor name / Language: en Invention title: B7-H4 ANTIBODIES AND ANTI-B7-H4 ANTIBODY/IL-15 FUSION PROTEINS ( en ) Sequence Total Quantity: 189 Sequences: Sequence Number (ID): 1 Length: 117 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..117 > note, Synthetic: 1A12 VH - source, 1..117 > mol_type, protein > organism, synthetic construct Residues: EVQLLESGGG LVKPGGSLRL SCAASGFTFS SYAMHWVRQA PGKGLEWVAV ISYDGSNKYY 60 ADSVKGRFTI SRDDSKNTLY LQMNSLKTED TAVYYCARHG WDAFDIWGQG TLVTVSS 117 Sequence Number (ID): 2 Length: 107 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..107 > note, Synthetic: 1A12 VL - source, 1..107 > mol_type, protein > organism, synthetic construct Residues: DIQMTQSPSS LSASVGDRVT ITCRASQDIS NRLNWYQQKP GKAPKLLIYL ASSLQGGVPS 60 RFSGSGSGTD FTLTISSLQP EDFATYYCQQ AISFPLTFGG GTKVEIK 107 Sequence Number (ID): 3 Length: 121 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..121 > note, Synthetic: 1D3 VH - source, 1..121 > mol_type, protein > organism, synthetic construct Residues: EVQLLESGGG LVQPGGSLRL SCAASGFTFN THAMHWVRQA PGKGLEWVSA ISGSGGSTYY 60 ADSVKGRFTI SRDISKNTLY LQMNSLRAED TAVYYCARLL GRFGEYGMDV WGQGTTVTVS 120 S 121 Sequence Number (ID): 4 Length: 10 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..10 > note, Synthetic: 1D3 CDR1H - source, 1..10 > mol_type, protein > organism, synthetic construct Residues: GFTFNTHAMH 10 Sequence Number (ID): 5 Length: 17 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..17 > note, Synthetic: 1D3 CDR2H - source, 1..17 > mol_type, protein > organism, synthetic construct Residues: AISGSGGSTY YADSVKG 17 Sequence Number (ID): 6 Length: 12 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..12 > note, Synthetic: 1D3 CDR3H - source, 1..12 > mol_type, protein > organism, synthetic construct Residues: LLGRFGEYGM DV 12 Sequence Number (ID): 7 Length: 107 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..107 > note, Synthetic: 1D3 VL - source, 1..107 > mol_type, protein > organism, synthetic construct Residues: DIQMTQSPSS LSASVGDRVT ITCRASRSIY TWLAWYQQKP GKAPKLLIYD ASTLQSGVPS 60 RFSGSGSGTD FTLTISSLQP EDFATYYCQQ SYSTPYTFGG GTKVEIK 107 Sequence Number (ID): 8 Length: 11 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..11 > note, Synthetic: 1D3 CDR1L - source, 1..11 > mol_type, protein > organism, synthetic construct Residues: RASRSIYTWL A 11 Sequence Number (ID): 9 Length: 5 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..5 > note, Synthetic: 1D3 CDR2L - source, 1..5 > mol_type, protein > organism, synthetic construct Residues: STLQS 5 Sequence Number (ID): 10 Length: 9 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..9 > note, Synthetic: 1D3 CDR3L - source, 1..9 > mol_type, protein > organism, synthetic construct Residues: QQSYSTPYT 9 Sequence Number (ID): 11 Length: 116 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..116 > note, Synthetic: 1F11 VH - source, 1..116 > mol_type, protein > organism, synthetic construct Residues: QVQLVQSGAE VKKPGSSVKV SCKASGDTFT TYQIHWVRQA PGQGLEWMGG IMPIFGTTKY 60 AQNFQGRVTI TADESTSTAY MELSSLRSED TAVYYCARRN YGMDVWGQGT TVTVSS 116 Sequence Number (ID): 12 Length: 113 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..113 > note, Synthetic: 1F11 VL - source, 1..113 > mol_type, protein > organism, synthetic construct Residues: DIVMTQSPDS LAVSLGERAT INCKSSQSLL YRPVNKNFLA WYQQKPGQPP KLLIYWASTR 60 GSGVPDRFSG SGSGTDFTLT ISSLQAEDVA TYFCQQYYST PITFGQGTKV EIK 113 Sequence Number (ID): 13 Length: 116 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..116 > note, Synthetic: 3D1 VH - source, 1..116 > mol_type, protein > organism, synthetic construct Residues: QVQLVQSGAE VKKPGSSVKV SCKASGYSFI SYAITWVRQA PGQGLEWIGG INPIFGTAKY 60 AQKFQGRVTI TADESTSTAY MELSSLRSED TAVYYCAKGQ ALIQHWGQGT LVTVSS 116 Sequence Number (ID): 14 Length: 113 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..113 > note, Synthetic: 3D1 VL - source, 1..113 > mol_type, protein > organism, synthetic construct Residues: DIVMTQSPDS LAVSLGERAT INCKSSQSVL SSSNNKNYLA WYQQKPGQPP KLLIYWASTR 60 ESGVPDRFSG SGSGTDFTLT ISSLQAEDVA VYYCQQYYST PLAFGQGTKV EIK 113 Sequence Number (ID): 15 Length: 116 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..116 > note, Synthetic: 3F2 VH - source, 1..116 > mol_type, protein > organism, synthetic construct Residues: QVQLVQSGAE VKKPGASVKV SCKASGYTFT AQYMYWVRQA PGQGLEWMGR INPTSGNTVY 60 AQKLQGRVTM TRDTSTSTVY MELSSLRSED TAVYYCARGI NWFDPWGQGT LVTVSS 116 Sequence Number (ID): 16 Length: 10 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..10 > note, Synthetic: 3F2 CDR1H - source, 1..10 > mol_type, protein > organism, synthetic construct Residues: GYTFTAQYMY 10 Sequence Number (ID): 17 Length: 17 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..17 > note, Synthetic: 3F2 CDR2H - source, 1..17 > mol_type, protein > organism, synthetic construct Residues: RINPTSGNTV YAQKLQG 17 Sequence Number (ID): 18 Length: 7 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..7 > note, Synthetic: 3F2 CDR3H - source, 1..7 > mol_type, protein > organism, synthetic construct Residues: GINWFDP 7 Sequence Number (ID): 19 Length: 107 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..107 > note, Synthetic: 3F2 VL - source, 1..107 > mol_type, protein > organism, synthetic construct Residues: DIQMTQSPSS LSASVGDRVT ITCRASQSIS SYLNWYQQKP GKAPKLLIYA ASSLQSGVPS 60 RFSGSGSGTD FTLTISSLQP EDFATYYCQQ SYSTPLTFGG GTKVEIK 107 Sequence Number (ID): 20 Length: 11 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..11 > note, Synthetic: 3F2 CDR1L - source, 1..11 > mol_type, protein > organism, synthetic construct Residues: RASQSISSYL N 11 Sequence Number (ID): 21 Length: 5 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..5 > note, Synthetic: 3F2 CDR2L - source, 1..5 > mol_type, protein > organism, synthetic construct Residues: SSLQS 5 Sequence Number (ID): 22 Length: 9 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..9 > note, Synthetic: 3F2 CDR3L - source, 1..9 > mol_type, protein > organism, synthetic construct Residues: QQSYSTPLT 9 Sequence Number (ID): 23 Length: 118 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..118 > note, Synthetic: 4H6 VH - source, 1..118 > mol_type, protein > organism, synthetic construct Residues: EVQLLESGGG LVQPGGSLRL SCAASGFTFS SYGMHWVRQA PGKGLEWVSG ISGSGGSTYY 60 ADSVKGRFTI SRDNSKNTLY LQMNSLRAED TAVYYCARTQ WRASLDPWGQ GTLVNVSS 118 Sequence Number (ID): 24 Length: 107 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..107 > note, Synthetic: 4H6 VL - source, 1..107 > mol_type, protein > organism, synthetic construct Residues: DIQMTQSPSS LSASVGDRVT ITCRASQDIS YWLAWYQQKP GKAPKLLIYG ASTLQSGVPS 60 RFSGSGSGTD FTLTISSLQP EDFATYYCQQ TTMSPYTFGQ GTKVEIK 107 Sequence Number (ID): 25 Length: 120 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..120 > note, Synthetic: 6C3 VH - source, 1..120 > mol_type, protein > organism, synthetic construct Residues: EVQLLESGGG LVQPGGSLRL SCAASGFTFS SYAMHWVRQA PGKGLEWVAS ISGTGFTTRY 60 ADSVKGRFTI SRDNSKNTLY LQMNSLRAED TAVYYCARGG WFRDTPVDYW GQGTLVTVSS 120 Sequence Number (ID): 26 Length: 112 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..112 > note, Synthetic: 6C3 VL - source, 1..112 > mol_type, protein > organism, synthetic construct Residues: DIVMTQSPLS LPVTPGEPAS ISCRSSQSLL HSNGYNYLDW YLQKPGQSPQ LLIYGASSLR 60 SGVPDRFSGS GSGTDFTLKI SRVEAZDVGV YYCMQASHWP PTFGQGTRLE IK 112 Sequence Number (ID): 27 Length: 115 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..115 > note, Synthetic: 9H2 VH - source, 1..115 > mol_type, protein > organism, synthetic construct Residues: QVQLVQSGAE VKKPGSSVKV SCKASGGTFS TYAINWVRQA PGQGLEWMGG INPMFGTARY 60 AQKFQGRVTI TADESTSTAY MELSSLRSED TAVYYCARGR LHRHWGQGTL VTVSS 115 Sequence Number (ID): 28 Length: 113 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..113 > note, Synthetic: 9H2 VL - source, 1..113 > mol_type, protein > organism, synthetic construct Residues: DIVMTQSPDS LAVSLGERAT INCKSSQSVL YSSNNKNYLA WYQQKPGQPP KLLIYWASTR 60 ESGVPDRFSG SGSGTDFTLT ISSLQAEDVA VYYCQQYYTT PITFGQGTRL EIK 113 Sequence Number (ID): 29 Length: 122 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..122 > note, Synthetic: 4B9 VH - source, 1..122 > mol_type, protein > organism, synthetic construct Residues: QVQLVQSGAE VKKPGASVKV SCKASGYTFT SYYMHWVRQA PGQGLEWMGW MNPNSGNTGY 60 AQKFQGRVTM TRDTSTSTVY MELSSLRSED TAVYYCARGQ GRYLNYYYMD VWGKGTTVTV 120 SS 122 Sequence Number (ID): 30 Length: 107 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..107 > note, Synthetic: 4B9 VL - source, 1..107 > mol_type, protein > organism, synthetic construct Residues: DIQMTQSPSS LSASVGDRVT ITCRVSQGIS NYLAWYQQKP GKAPKLLIYD ASSLQSGVPS 60 RFSGSGSGTD FTLTISSLQP EDFATYYCQQ SYSTPFTFGP GTKVDIK 107 Sequence Number (ID): 31 Length: 118 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..118 > note, Synthetic: 15B11 VH - source, 1..118 > mol_type, protein > organism, synthetic construct Residues: QVQLVQSGAE VKKPGASVKV SCKASGYTFT GYYIHWVRQA PGQGLEWMGW MNPHSGHTGY 60 AQNLQGRVTM TRDTSTSTVY MELSSLRSED TAVYYCARVK VTTGFDYWGQ GTLVTVSS 118 Sequence Number (ID): 32 Length: 112 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..112 > note, Synthetic: 15B11 VL - source, 1..112 > mol_type, protein > organism, synthetic construct Residues: DIVMTQSPLS LPVTPGEPAS ISCRSSQSLL HSNGYNYLDW YLQKPGQSPQ LLIYLGSNRA 60 SGVPDRFSGS GSGTDFTLKI SRVEAEDVGV YYCMQGTHWP PTFGQGTKLE IK 112 Sequence Number (ID): 33 Length: 118 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..118 > note, Synthetic: 24B6 VH - source, 1..118 > mol_type, protein > organism, synthetic construct Residues: QVQLVQSGAE VKKPGASVKV SCKASGYTFT GYYMHWVRQA PGQGLEWIGW MNPNSGDTGY 60 AQKFQGRVTM TRDTSTSTVY MELSSLRSED TAVYYCAKVG AYGGMDVWGQ GTTVTVSS 118 Sequence Number (ID): 34 Length: 112 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..112 > note, Synthetic: 24B6 VL - source, 1..112 > mol_type, protein > organism, synthetic construct Residues: DIVMTQSPLS LPVTPGEPAS ISCRSSQSLL HSNGYNYLDW YLQKPGQSPQ LLIYGGSNRA 60 SGVPDRFSGS GSGTDFTLKI SRVEAEDVGV YYCMQGTHWP PTFGPGTKVD IK 112 Sequence Number (ID): 35 Length: 119 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..119 > note, Synthetic: 24F4 VH - source, 1..119 > mol_type, protein > organism, synthetic construct Residues: QVQLVQSGAE VKKPGSSVKV SCKASGYRFT GDYIHWVRQA PGQGLEWMGW MNPNSGNTGL 60 AQKFQGRVTI TADESTSTAY MELSSLRSED TAVYYCARVL GFSGGMDVWG QGTTVTVSS 119 Sequence Number (ID): 36 Length: 112 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..112 > note, Synthetic: 24F4 VL - source, 1..112 > mol_type, protein > organism, synthetic construct Residues: DIVMTQSPLS LPVTPGEPAS ISCRSSQSLL HSNGYNYLDW YLQKPGQSPQ LLIYAASSLR 60 SGVPDRFSGS GSGTDFTLKI SRVEAEDVGV YYCMQGTHWP PTFGQGTKLE IK 112 Sequence Number (ID): 37 Length: 118 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..118 > note, Synthetic: 30G4 VH - source, 1..118 > mol_type, protein > organism, synthetic construct Residues: QVQLVQSGAE VKKPGASVKV SCKASGYTFS SYYMHWVRQA PGQGLEWMGW MNPNSGDTGY 60 AQKFQGRVTM TRDTSTSTVY MELSSLRSED TAVYYCARVP ETGGMDVWGQ GTTVTVSS 118 Sequence Number (ID): 38 Length: 112 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..112 > note, Synthetic: 30G4 VL - source, 1..112 > mol_type, protein > organism, synthetic construct Residues: DIVMTQSPLS LPVTPGEPAS ISCRSSQSLL HSNGYNYLDW YLQKPGQSPQ LLIYGASSLH 60 SGVPDRFSGS GSGTDFTLKI SRVEAEDVGV YYCMQGTHWP PTFGQGTKVE IK 112 Sequence Number (ID): 39 Length: 127 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..127 > note, Synthetic: 5E4 VH - source, 1..127 > mol_type, protein > organism, synthetic construct Residues: QVQLVQSGAE VKKPGASVKV SCKASGYTFT SYDINWVRQA PGQGLEWMGW MNPNSGNTGY 60 AQKFQGRVTM TRDTSTSTVY MELSSLRSED TAVYYCARGE LWFGEFDYYY YYGMDVWGQG 120 TTVTVSS 127 Sequence Number (ID): 40 Length: 107 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..107 > note, Synthetic: 5E4 VL - source, 1..107 > mol_type, protein > organism, synthetic construct Residues: DIQMTQSPSS LSASVGDRVT ITCRASQSIS SYLNWYQQKP GKAPKLLIYG ASSLQSGVPS 60 RFSGSGSGTD FTLTISSLQP EDFATYYCQQ ADRIPFTFGR GTKVEIK 107 Sequence Number (ID): 41 Length: 120 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..120 > note, Synthetic: 5F4 VH - source, 1..120 > mol_type, protein > organism, synthetic construct Residues: EVQLLESGGG LVKPGGSLRL SCAASGFTFS SYAMHWVRQA PGKGLEWVSA IGGSGRTTYY 60 ADSVKGRFTI SRDDSKNTLY LQMNSLKTED TAVYYCARER GYSYGQIDYW GQGTLVTVSS 120 Sequence Number (ID): 42 Length: 112 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..112 > note, Synthetic: 5F4 VL - source, 1..112 > mol_type, protein > organism, synthetic construct Residues: DIVMTQSPLS LPVTPGEPAS ISCRSSQSLL HSNGYNYLDW YLQKPGQSPQ LLIYAASSLQ 60 SGVPDRFSGS GSGTDFTLKI SRVEAEDVGV YYCMQGAHWP LTFGQGTKVE IK 112 Sequence Number (ID): 43 Length: 119 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..119 > note, Synthetic: 5G6 VH - source, 1..119 > mol_type, protein > organism, synthetic construct Residues: QVQLVQSGAE VKKPGASVKV SCKASGYTFT SYYMHWVRQA PGQGLEWLGW VNPNTGTTRF 60 AQKFQGRVTM TRDTSTSTVY MELSSLRSED TAVYYCARDA NYYYGMDVWG QGTMVTVSS 119 Sequence Number (ID): 44 Length: 114 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..114 > note, Synthetic: 5G6 VL - source, 1..114 > mol_type, protein > organism, synthetic construct Residues: DIVMTQSPDS LAVSLGERAT INCKSSQSVL YSSNNKNYLA WYQQKPGQPP KLLIYWASTR 60 ESGVPDRFSG SGSGTDFTLT ISSLQAEDVA TYYCQKYNSA LPITFGQGTR LEIK 114 Sequence Number (ID): 45 Length: 120 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..120 > note, Synthetic: 9D11 VH - source, 1..120 > mol_type, protein > organism, synthetic construct Residues: QVQLVQSGAE VKKPGASVKV SCKASGYTFT SYGISWVRQA PGQGLEWVGV INPNGGTTTY 60 AQTFQGRVTM TRDTSTSTVY MELSSLRSED TAVYYCARTG YSSGWAFDYW GRGTLVTVSS 120 Sequence Number (ID): 46 Length: 10 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..10 > note, Synthetic: 9D11 CDR1H - source, 1..10 > mol_type, protein > organism, synthetic construct Residues: GYTFTSYGIS 10 Sequence Number (ID): 47 Length: 17 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..17 > note, Synthetic: 9D11 CDR2H - source, 1..17 > mol_type, protein > organism, synthetic construct Residues: VINPNGGTTT YAQTFQG 17 Sequence Number (ID): 48 Length: 11 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..11 > note, Synthetic: 9D11 CDR3H - source, 1..11 > mol_type, protein > organism, synthetic construct Residues: TGYSSGWAFD Y 11 Sequence Number (ID): 49 Length: 112 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..112 > note, Synthetic: 9D11 VL - source, 1..112 > mol_type, protein > organism, synthetic construct Residues: DIVMTQSPDS LAVSLGERAT INCKSSQSVL YSSNNKNYLA WYQQKPGQPP KLLIYWASTR 60 ESGVPDRFSG SGSGTDFTLT ISSLQAEDVA VYYCQQYFST PSFGQGTKVE IK 112 Sequence Number (ID): 50 Length: 17 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..17 > note, Synthetic: 9D11 CDR1L - source, 1..17 > mol_type, protein > organism, synthetic construct Residues: KSSQSVLYSS NNKNYLA 17 Sequence Number (ID): 51 Length: 5 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..5 > note, Synthetic: 9D11 CDR2L - source, 1..5 > mol_type, protein > organism, synthetic construct Residues: STRES 5 Sequence Number (ID): 52 Length: 8 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..8 > note, Synthetic: 9D11 CDR3L - source, 1..8 > mol_type, protein > organism, synthetic construct Residues: QQYFSTPS 8 Sequence Number (ID): 53 Length: 119 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..119 > note, Synthetic: 9E1 VH - source, 1..119 > mol_type, protein > organism, synthetic construct Residues: QVQLVQSGAE VKKPGASVKV SCKASGYTFT GYYLHWVRQA PGQGLEWMGW INPNSGGTNS 60 AQRFQGRVTM TRDTSTSTVY MELSSLRSED TAVYYCARVR GYEGGMDVWG QGTTVTVSS 119 Sequence Number (ID): 54 Length: 112 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..112 > note, Synthetic: 9E1 VL - source, 1..112 > mol_type, protein > organism, synthetic construct Residues: DIVMTQSPLS LPVTPGEPAS ISCRSSQSLL HSNGYNYLDW YLQKPGQSPQ LLIYLGSNRA 60 SGVPDRFSGS GSGTDFTLKI SRVEAEDVGV YYCMQGSHWP PTFGQGTRLE IK 112 Sequence Number (ID): 55 Length: 118 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..118 > note, Synthetic: 31D7 VH - source, 1..118 > mol_type, protein > organism, synthetic construct Residues: EVQLLESGGG LVQPGGSXRL SCAASGFTFS SYGMHWVRQA PGKGLEWVSS ISSSSSYIYY 60 ADSVKGRFTI SRDNSKNTLY LQMNSLRAED TAVYYCARIG SGGSLDYWGQ GTLVTVSS 118 Sequence Number (ID): 56 Length: 107 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..107 > note, Synthetic: 31D7 VL - source, 1..107 > mol_type, protein > organism, synthetic construct Residues: DIQMTQSPSS LSASVGDRVT ITCRASQSIS NWLAWYQQKP GKAPKLLIYA ASSLQSGVPS 60 RFSGSGSGTD FTLTISSLQP EDFATYYCQQ SYTIPITFGQ GTRLEIK 107 Sequence Number (ID): 57 Length: 116 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..116 > note, Synthetic: 39A11 VH - source, 1..116 > mol_type, protein > organism, synthetic construct Residues: EVQLLESGGG LVQPGGSLRL SCAASGFTFS SYGMHWVRQA PGKGLEWVAS ISSSSGYIYY 60 ADSVKGRFTI SRDNSKNTLY LQMNSLRAED TAVYYCARAS SGMDVWGQGT TVTVSS 116 Sequence Number (ID): 58 Length: 10 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..10 > note, Synthetic: 39A11 CDR1H - source, 1..10 > mol_type, protein > organism, synthetic construct Residues: GFTFSSYGMH 10 Sequence Number (ID): 59 Length: 17 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..17 > note, Synthetic: 39A11 CDR2H - source, 1..17 > mol_type, protein > organism, synthetic construct Residues: SISSSSGYIY YADSVKG 17 Sequence Number (ID): 60 Length: 7 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..7 > note, Synthetic: 39A11 CDR3H - source, 1..7 > mol_type, protein > organism, synthetic construct Residues: ASSGMDV 7 Sequence Number (ID): 61 Length: 107 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..107 > note, Synthetic: 39A11 VL - source, 1..107 > mol_type, protein > organism, synthetic construct Residues: DIQMTQSPSS LSASVGDRVT ITCRASQTIR SYLNWYQQKP GKAPKLLIYA ASHLQSGVPS 60 RFSGSGSGTD FTLTISSLQP EDFATYYCQQ SYTTPYTFGQ GTKLEIK 107 Sequence Number (ID): 62 Length: 11 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..11 > note, Synthetic: 39A11 CDR1L - source, 1..11 > mol_type, protein > organism, synthetic construct Residues: RASQTIRSYL N 11 Sequence Number (ID): 63 Length: 5 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..5 > note, Synthetic: 39A11 CDR2L - source, 1..5 > mol_type, protein > organism, synthetic construct Residues: SHLQS 5 Sequence Number (ID): 64 Length: 9 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..9 > note, Synthetic: 39A11 CDR3L - source, 1..9 > mol_type, protein > organism, synthetic construct Residues: QQSYTTPYT 9 Sequence Number (ID): 65 Length: 106 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..106 > note, Synthetic: 49A2 VL - source, 1..106 > mol_type, protein > organism, synthetic construct Residues: DIQMTQSPSS LSASVGDRVT ITCRASQNID TYVNWYQQKP GKAPKLLIYA ASRLHTVPSR 60 FSGSGSGTDF TLTISSLQPE DFATYYCQQS YTSPFTFGGG TKVEIK 106 Sequence Number (ID): 66 Length: 11 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..11 > note, Synthetic: 49A2 CDR1L - source, 1..11 > mol_type, protein > organism, synthetic construct Residues: RASQNIDTYV N 11 Sequence Number (ID): 67 Length: 5 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..5 > note, Synthetic: 49A2 CDR2L - source, 1..5 > mol_type, protein > organism, synthetic construct Residues: SRLHT 5 Sequence Number (ID): 68 Length: 9 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..9 > note, Synthetic: 49A2 CDR3L - source, 1..9 > mol_type, protein > organism, synthetic construct Residues: QQSYTSPFT 9 Sequence Number (ID): 69 Length: 107 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..107 > note, Synthetic: 50A10 VL - source, 1..107 > mol_type, protein > organism, synthetic construct Residues: DIQMTQSPSS LSASVGDRVT ITCQASQDIS NYINWYQQKP GKAPKLLIYA ASRLQSGVPS 60 RFSGSGSGTD FTLTISSLQP EDFATYYCQQ SYRSPFTFGQ GTKLEIK 107 Sequence Number (ID): 70 Length: 11 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..11 > note, Synthetic: 50A10 CDR1L - source, 1..11 > mol_type, protein > organism, synthetic construct Residues: QASQDISNYI N 11 Sequence Number (ID): 71 Length: 5 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..5 > note, Synthetic: 50A10 CDR2L - source, 1..5 > mol_type, protein > organism, synthetic construct Residues: SRLQS 5 Sequence Number (ID): 72 Length: 9 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..9 > note, Synthetic: 50A10 CDR3L - source, 1..9 > mol_type, protein > organism, synthetic construct Residues: QQSYRSPFT 9 Sequence Number (ID): 73 Length: 11 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..11 > note, Synthetic: 3F2 CDR motif CDR1L - VARIANT, 1 > note, X is R or Q - VARIANT, 5 > note, X is D, N, or S - VARIANT, 7 > note, X is D or S - VARIANT, 8 > note, X is N, S, or T - VARIANT, 10 > note, X is I, L, or V - source, 1..11 > mol_type, protein > organism, synthetic construct Residues: XASQXIXXYX N 11 Sequence Number (ID): 74 Residues: 000 Sequence Number (ID): 75 Length: 9 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..9 > note, Synthetic: 3F2 CDR motif CDR3L - VARIANT, 5 > note, X is R, S, or T - VARIANT, 6 > note, X is S or T - VARIANT, 8 > note, X is F or L - source, 1..9 > mol_type, protein > organism, synthetic construct Residues: QQSYXXPXT 9 Sequence Number (ID): 76 Length: 107 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..107 > note, Synthetic: 45A2 VL - source, 1..107 > mol_type, protein > organism, synthetic construct Residues: DIQMTQSPSS LSASVGDRVT ITCRASQNIY TWLAWYQQKP GKAPKLLIYD ATNLPTGVPS 60 RFSGSGSGTD FTLTISSLQP EDFATYYCQQ SYSTRWTFGG GTKVEIK 107 Sequence Number (ID): 77 Length: 11 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..11 > note, Synthetic: 45A2 CDR1L - source, 1..11 > mol_type, protein > organism, synthetic construct Residues: RASQNIYTWL A 11 Sequence Number (ID): 78 Length: 5 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..5 > note, Synthetic: 45A2 CDR2L - source, 1..5 > mol_type, protein > organism, synthetic construct Residues: TNLPT 5 Sequence Number (ID): 79 Length: 9 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..9 > note, Synthetic: 45A2 CDR3L - source, 1..9 > mol_type, protein > organism, synthetic construct Residues: QQSYSTRWT 9 Sequence Number (ID): 80 Length: 107 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..107 > note, Synthetic: 47B2 VL - source, 1..107 > mol_type, protein > organism, synthetic construct Residues: DIQMTQSPSS LSASVGDRVT ITCRASQTVY TWLAWYQQKP GKAPKLLIYD ATNLATGVPS 60 RFSGSGSGTD FTLTISSLQP EDFATYYCQQ SYSTSWTFGG GTKVEIK 107 Sequence Number (ID): 81 Length: 11 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..11 > note, Synthetic: 47B2 CDR1L - source, 1..11 > mol_type, protein > organism, synthetic construct Residues: RASQTVYTWL A 11 Sequence Number (ID): 82 Length: 5 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..5 > note, Synthetic: 47B2 CDR2L - source, 1..5 > mol_type, protein > organism, synthetic construct Residues: TNLAT 5 Sequence Number (ID): 83 Length: 9 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..9 > note, Synthetic: 47B2 CDR3L - source, 1..9 > mol_type, protein > organism, synthetic construct Residues: QQSYSTSWT 9 Sequence Number (ID): 84 Length: 11 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..11 > note, Synthetic: 1D3 CDR motif CDR1L - VARIANT, 4 > note, X is Q or R - VARIANT, 5 > note, X is N, S, or T - VARIANT, 6 > note, X is I or V - source, 1..11 > mol_type, protein > organism, synthetic construct Residues: RASXXXYTWL A 11 Sequence Number (ID): 85 Residues: 000 Sequence Number (ID): 86 Length: 9 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..9 > note, Synthetic: 1D3 CDR motif CDR3L - VARIANT, 7 > note, X is P, R, or S - VARIANT, 8 > note, X is W or Y - source, 1..9 > mol_type, protein > organism, synthetic construct Residues: QQSYSTXXT 9 Sequence Number (ID): 87 Length: 112 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..112 > note, Synthetic: 67E12 VL - source, 1..112 > mol_type, protein > organism, synthetic construct Residues: DIVMTQSPDS LAVSLGERAT INCKSSQSVL YSSNNKNYLA WYQQKPGQPP KLLIYWASKR 60 VSGVPDRFSG SGSGTDFTLT ISSLQAEDVA VYYCQQYFDS PTFGQGTKVE IK 112 Sequence Number (ID): 88 Length: 17 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..17 > note, Synthetic: 67E12 CDR1L - source, 1..17 > mol_type, protein > organism, synthetic construct Residues: KSSQSVLYSS NNKNYLA 17 Sequence Number (ID): 89 Length: 5 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..5 > note, Synthetic: 67E12 CDR2L - source, 1..5 > mol_type, protein > organism, synthetic construct Residues: SKRVS 5 Sequence Number (ID): 90 Length: 8 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..8 > note, Synthetic: 67E12 CDR3L - source, 1..8 > mol_type, protein > organism, synthetic construct Residues: QQYFDSPT 8 Sequence Number (ID): 91 Length: 112 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..112 > note, Synthetic: 67C6 VL - source, 1..112 > mol_type, protein > organism, synthetic construct Residues: DIVMTQSPDS LAVSLGERAT INCKSSQSVL SSSNNKNYLA WYQQKPGQPP KLLIYWASTR 60 QSGVPDRFSG SGSGTDFTLT ISSLQAEDVA VYYCQQYYSD PTFGQGTKVE IK 112 Sequence Number (ID): 92 Length: 17 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..17 > note, Synthetic: 67C6 CDR1L - source, 1..17 > mol_type, protein > organism, synthetic construct Residues: KSSQSVLSSS NNKNYLA 17 Sequence Number (ID): 93 Length: 5 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..5 > note, Synthetic: 67C6 CDR2L - source, 1..5 > mol_type, protein > organism, synthetic construct Residues: STRQS 5 Sequence Number (ID): 94 Length: 8 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..8 > note, Synthetic: 67C6 CDR3L - source, 1..8 > mol_type, protein > organism, synthetic construct Residues: QQYYSDPT 8 Sequence Number (ID): 95 Length: 112 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..112 > note, Synthetic: 67C3 VL - source, 1..112 > mol_type, protein > organism, synthetic construct Residues: DIVMTQSPDS LAVSLGERAT INCKSSQSVL YSSNNKNYLA WYQQKPGQPP KLLIYWASTR 60 ASGVPDRFSG SGSGTDFTLT ISSLQAEDVA VYYCQQYYDT PTFGQGTKVE IK 112 Sequence Number (ID): 96 Length: 17 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..17 > note, Synthetic: 67C3 CDR1L - source, 1..17 > mol_type, protein > organism, synthetic construct Residues: KSSQSVLYSS NNKNYLA 17 Sequence Number (ID): 97 Length: 5 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..5 > note, Synthetic: 67C3 CDR2L - source, 1..5 > mol_type, protein > organism, synthetic construct Residues: STRAS 5 Sequence Number (ID): 98 Length: 8 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..8 > note, Synthetic: 67C3 CDR3L - source, 1..8 > mol_type, protein > organism, synthetic construct Residues: QQYYDTPT 8 Sequence Number (ID): 99 Length: 112 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..112 > note, Synthetic: 67G3 VL - source, 1..112 > mol_type, protein > organism, synthetic construct Residues: DIVMTQSPDS LAVSLGERAT INCKSSQSVL SSSNNKNYLA WYQQKPGQPP KLLIYWASTR 60 QSGVPDRFSG SGSGTDFTLT ISSLQAEDVA VYYCQQYYTS PTFGQGTKVE IK 112 Sequence Number (ID): 100 Length: 17 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..17 > note, Synthetic: 67G3 CDR1L - source, 1..17 > mol_type, protein > organism, synthetic construct Residues: KSSQSVLSSS NNKNYLA 17 Sequence Number (ID): 101 Length: 5 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..5 > note, Synthetic: 67G3 CDR2L - source, 1..5 > mol_type, protein > organism, synthetic construct Residues: STRQS 5 Sequence Number (ID): 102 Length: 8 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..8 > note, Synthetic: 67G3 CDR3L - source, 1..8 > mol_type, protein > organism, synthetic construct Residues: QQYYTSPT 8 Sequence Number (ID): 103 Length: 112 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..112 > note, Synthetic: 67H9 VL - source, 1..112 > mol_type, protein > organism, synthetic construct Residues: DIVMTQSPDS LAVSLGERAT INCRSSQSVL YSSNNKNYLA WYQQKPGQPP KLLIYWASNR 60 KSGVPDRFSG SGSGTDFTLT ISSLQAEDVA VYYCQQYYSA PTFGQGTKVE IK 112 Sequence Number (ID): 104 Length: 17 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..17 > note, Synthetic: 67H9 CDR1L - source, 1..17 > mol_type, protein > organism, synthetic construct Residues: RSSQSVLYSS NNKNYLA 17 Sequence Number (ID): 105 Length: 5 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..5 > note, Synthetic: 67H9 CDR2L - source, 1..5 > mol_type, protein > organism, synthetic construct Residues: SNRKS 5 Sequence Number (ID): 106 Length: 8 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..8 > note, Synthetic: 67H9 CDR3L - source, 1..8 > mol_type, protein > organism, synthetic construct Residues: QQYYSAPT 8 Sequence Number (ID): 107 Length: 112 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..112 > note, Synthetic: 68F5 VL - source, 1..112 > mol_type, protein > organism, synthetic construct Residues: DIVMTQSPDS LAVSLGERAT INCKSSRSVL SRSNNKNYLA WYQQKPGQPP KLLIYWASTR 60 QFGVPDRFSG SGSGTDFTLT ISSLQAEDVA VYYCQQYYDT PTFGQGTKVE IK 112 Sequence Number (ID): 108 Length: 17 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..17 > note, Synthetic: 68F5 CDR1L - source, 1..17 > mol_type, protein > organism, synthetic construct Residues: KSSRSVLSRS NNKNYLA 17 Sequence Number (ID): 109 Length: 5 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..5 > note, Synthetic: 68F5 CDR2L - source, 1..5 > mol_type, protein > organism, synthetic construct Residues: STRQF 5 Sequence Number (ID): 110 Length: 8 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..8 > note, Synthetic: 68F5 CDR3L - source, 1..8 > mol_type, protein > organism, synthetic construct Residues: QQYYDTPT 8 Sequence Number (ID): 111 Length: 17 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..17 > note, Synthetic: 9D11 CDR motif CDR1L - VARIANT, 1 > note, X is K or R - VARIANT, 4 > note, X is Q or R - VARIANT, 8 > note, X is S or Y - VARIANT, 9 > note, X is R or S - source, 1..17 > mol_type, protein > organism, synthetic construct Residues: XSSXSVLXXS NNKNYLA 17 Sequence Number (ID): 112 Residues: 000 Sequence Number (ID): 113 Length: 8 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..8 > note, Synthetic: 9D11 CDR motif CDR3L - VARIANT, 4 > note, X is F or Y - VARIANT, 5 > note, X is D, S, or T - VARIANT, 6 > note, X is A, D, S, or T - VARIANT, 8 > note, X is S or T - source, 1..8 > mol_type, protein > organism, synthetic construct Residues: QQYXXXPX 8 Sequence Number (ID): 114 Length: 107 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..107 > note, Synthetic: 57H3 VL - source, 1..107 > mol_type, protein > organism, synthetic construct Residues: DIQMTQSPSS LSASVGDRVT ITCQASQDIR KYLNWYQQKP GKAPKLLIYA ASTRESGVPS 60 RFSGSGSGTD FTLTISSLQP EDFATYYCQQ YYSLPLTFGQ GTKLEIK 107 Sequence Number (ID): 115 Length: 11 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..11 > note, Synthetic: 57H3 CDR1L - source, 1..11 > mol_type, protein > organism, synthetic construct Residues: QASQDIRKYL N 11 Sequence Number (ID): 116 Length: 5 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..5 > note, Synthetic: 57H3 CDR2L - source, 1..5 > mol_type, protein > organism, synthetic construct Residues: STRES 5 Sequence Number (ID): 117 Length: 9 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..9 > note, Synthetic: 57H3 CDR3L - source, 1..9 > mol_type, protein > organism, synthetic construct Residues: QQYYSLPLT 9 Sequence Number (ID): 118 Length: 107 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..107 > note, Synthetic: 57G8 VL - source, 1..107 > mol_type, protein > organism, synthetic construct Residues: DIQMTQSPSS LSASVGDRVT ITCRASQSIR SYLNWYQQKP GKAPKLLIYY ASSLQSGVPS 60 RFSGSGSGTD FTLTISSLQP EDFATYYCQQ YYSTPLTFGQ GTKVEIK 107 Sequence Number (ID): 119 Length: 11 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..11 > note, Synthetic: 57G8 CDR1L - source, 1..11 > mol_type, protein > organism, synthetic construct Residues: RASQSIRSYL N 11 Sequence Number (ID): 120 Length: 5 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..5 > note, Synthetic: 57G8 CDR2L - source, 1..5 > mol_type, protein > organism, synthetic construct Residues: SSLQS 5 Sequence Number (ID): 121 Length: 9 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..9 > note, Synthetic: 57G8 CDR3L - source, 1..9 > mol_type, protein > organism, synthetic construct Residues: QQYYSTPLT 9 Sequence Number (ID): 122 Length: 107 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..107 > note, Synthetic: 56A9 VL - source, 1..107 > mol_type, protein > organism, synthetic construct Residues: DIQMTQSPSS LSASVGDRVT ITCRASQSIS SYLNWYQQKP GKAPKLLIYA ASIRESGVPS 60 RFSGSGSGTD FTLTISSLQP EDFATYYCQQ YYTTPLTFGQ GTKLEIK 107 Sequence Number (ID): 123 Length: 11 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..11 > note, Synthetic: 56A9 CDR1L - source, 1..11 > mol_type, protein > organism, synthetic construct Residues: RASQSISSYL N 11 Sequence Number (ID): 124 Length: 5 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..5 > note, Synthetic: 56A9 CDR2L - source, 1..5 > mol_type, protein > organism, synthetic construct Residues: SIRES 5 Sequence Number (ID): 125 Length: 9 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..9 > note, Synthetic: 56A9 CDR3L - source, 1..9 > mol_type, protein > organism, synthetic construct Residues: QQYYTTPLT 9 Sequence Number (ID): 126 Length: 107 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..107 > note, Synthetic: 56H7 VL - source, 1..107 > mol_type, protein > organism, synthetic construct Residues: DIQMTQSPSS LSASVGDRVT ITCRASQSIS SYLNWYQQKP GKAPKLLIYA ASNLQSGVPS 60 RFSGSGSGTD FTLTISSLQP EDFATYYCQQ YYTTPLTFGQ GTKLEIK 107 Sequence Number (ID): 127 Length: 11 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..11 > note, Synthetic: 56H7 CDR1L - source, 1..11 > mol_type, protein > organism, synthetic construct Residues: RASQSISSYL N 11 Sequence Number (ID): 128 Length: 5 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..5 > note, Synthetic: 56H7 CDR2L - source, 1..5 > mol_type, protein > organism, synthetic construct Residues: SNLQS 5 Sequence Number (ID): 129 Length: 9 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..9 > note, Synthetic: 56H7 CDR3L - source, 1..9 > mol_type, protein > organism, synthetic construct Residues: QQYYTTPLT 9 Sequence Number (ID): 130 Length: 107 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..107 > note, Synthetic: 62F9 VL - source, 1..107 > mol_type, protein > organism, synthetic construct Residues: DIQMTQSPSS LSASVGDRVT ITCRASQSVS SAVAWYQQKP GKAPKLLIYA ASIRESGVPS 60 RFSGSGSGTD FTLTISSLQP EDFATYYCQQ YYSTPLTFGQ GTKLEIK 107 Sequence Number (ID): 131 Length: 11 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..11 > note, Synthetic: 62F9 CDR1L - source, 1..11 > mol_type, protein > organism, synthetic construct Residues: RASQSVSSAV A 11 Sequence Number (ID): 132 Length: 5 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..5 > note, Synthetic: 62F9 CDR2L - source, 1..5 > mol_type, protein > organism, synthetic construct Residues: SIRES 5 Sequence Number (ID): 133 Length: 9 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..9 > note, Synthetic: 62F9 CDR3L - source, 1..9 > mol_type, protein > organism, synthetic construct Residues: QQYYSTPLT 9 Sequence Number (ID): 134 Residues: 000 Sequence Number (ID): 135 Residues: 000 Sequence Number (ID): 136 Length: 9 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..9 > note, Synthetic: 39A11 CDR motif CDR3L - VARIANT, 3 > note, X is S or Y - VARIANT, 5 > note, X is S or T - VARIANT, 6 > note, X is L or T - VARIANT, 8 > note, X is L or Y - source, 1..9 > mol_type, protein > organism, synthetic construct Residues: QQXYXXPXT 9 Sequence Number (ID): 137 Length: 120 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..120 > note, Synthetic: Control antibody 1 VH - source, 1..120 > mol_type, protein > organism, synthetic construct Residues: QLQLQESGPG LVKPSETLSL TCTVSGGSIK SGSYYWGWIR QPPGKGLEWI GNIYYSGSTY 60 YNPSLRSRVT ISVDTSKNQF SLKLSSVTAA DTAVYYCARE GSYPNQFDPW GQGTLVTVSS 120 Sequence Number (ID): 138 Length: 107 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..107 > note, Synthetic: Control antibody 1 VL - source, 1..107 > mol_type, protein > organism, synthetic construct Residues: EIVMTQSPAT LSVSPGERAT LSCRASQSVS SNLAWYQQKP GQAPRLLIYG ASTRATGIPA 60 RFSGSGSGTE FTLTISSLQS EDFAVYYCQQ YHSFPFTFGG GTKVEIK 107 Sequence Number (ID): 139 Length: 115 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..115 > note, Synthetic: Control antibody 2 (antibody 6H3 described in US9,574,000) VH - source, 1..115 > mol_type, protein > organism, synthetic construct Residues: EVQLQQSGPV LVKPGTSVKM SCKASGYTFT DYYMNWVKQS HGKSLEWIGV INPYNGDTTY 60 NQKFKGKATL TVDKSSSTAY MEVNSLTFED SAVYYCARYP ESTYWGQGTL VTVSA 115 Sequence Number (ID): 140 Length: 112 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..112 > note, Synthetic: Control antibody 2 (antibody 6H3 described in US9,574,000) VL - source, 1..112 > mol_type, protein > organism, synthetic construct Residues: DVVMTQTPLS LPVSLGDQAS ISCRSSQSLV HINGNTYLHW YLQKPGQSPK VLIYKVSNRF 60 SGVPDRFSGS GSGTDFTLKI SRVEAEDLGV YFCSQSTHVP LTFGAGTKLE LK 112 Sequence Number (ID): 141 Length: 115 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..115 > note, Synthetic: DP47 VH - source, 1..115 > mol_type, protein > organism, synthetic construct Residues: EVQLLESGGG LVQPGGSLRL SCAASGFTFS SYAMSWVRQA PGKGLEWVSA ISGSGGSTYY 60 ADSVKGRFTI SRDNSKNTLY LQMNSLRAED TAVYYCAKGS GFDYWGQGTL VTVSS 115 Sequence Number (ID): 142 Length: 108 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..108 > note, Synthetic: DP47 VL - source, 1..108 > mol_type, protein > organism, synthetic construct Residues: EIVLTQSPGT LSLSPGERAT LSCRASQSVS SSYLAWYQQK PGQAPRLLIY GASSRATGIP 60 DRFSGSGSGT DFTLTISRLE PEDFAVYYCQ QYGSSPLTFG QGTKVEIK 108 Sequence Number (ID): 143 Length: 214 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..214 > note, Synthetic: 20502 VL - source, 1..214 > mol_type, protein > organism, synthetic construct Residues: EIVMTQSPAT LSVSPGERAT LSCRASQSVS SNLAWYQQKP GQAPRLLIYG ASTRATGIPA 60 RFSGSGSGTE FTLTISSLQS EDFAVYYCQQ YHSFPFTFGG GTKVEIKRTV AAPSVFIFPP 120 SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT 180 LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC 214 Sequence Number (ID): 144 Length: 214 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..214 > note, Synthetic: 57G8 VL - source, 1..214 > mol_type, protein > organism, synthetic construct Residues: DIQMTQSPSS LSASVGDRVT ITCRASQSIR SYLNWYQQKP GKAPKLLIYY ASSLQSGVPS 60 RFSGSGSGTD FTLTISSLQP EDFATYYCQQ YYSTPLTFGQ GTKVEIKRTV AAPSVFIFPP 120 SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT 180 LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC 214 Sequence Number (ID): 145 Length: 214 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..214 > note, Synthetic: 50A10 VL - source, 1..214 > mol_type, protein > organism, synthetic construct Residues: DIQMTQSPSS LSASVGDRVT ITCQASQDIS NYINWYQQKP GKAPKLLIYA ASRLQSGVPS 60 RFSGSGSGTD FTLTISSLQP EDFATYYCQQ SYRSPFTFGQ GTKLEIKRTV AAPSVFIFPP 120 SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT 180 LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC 214 Sequence Number (ID): 146 Length: 215 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..215 > note, Synthetic: DP47 VL - source, 1..215 > mol_type, protein > organism, synthetic construct Residues: EIVLTQSPGT LSLSPGERAT LSCRASQSVS SSYLAWYQQK PGQAPRLLIY GASSRATGIP 60 DRFSGSGSGT DFTLTISRLE PEDFAVYYCQ QYGSSPLTFG QGTKVEIKRT VAAPSVFIFP 120 PSDEQLKSGT ASVVCLLNNF YPREAKVQWK VDNALQSGNS QESVTEQDSK DSTYSLSSTL 180 TLSKADYEKH KVYACEVTHQ GLSSPVTKSF NRGEC 215 Sequence Number (ID): 147 Length: 450 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..450 > note, Synthetic: 20502 VH - source, 1..450 > mol_type, protein > organism, synthetic construct Residues: QLQLQESGPG LVKPSETLSL TCTVSGGSIK SGSYYWGWIR QPPGKGLEWI GNIYYSGSTY 60 YNPSLRSRVT ISVDTSKNQF SLKLSSVTAA DTAVYYCARE GSYPNQFDPW GQGTLVTVSS 120 ASTKGPSVFP LAPSSKSTSG GTAALGCLVK DYFPEPVTVS WNSGALTSGV HTFPAVLQSS 180 GLYSLSSVVT VPSSSLGTQT YICNVNHKPS NTKVDKKVEP KSCDKTHTCP PCPAPELLGG 240 PSVFLFPPKP KDTLMISRTP EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYN 300 STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPCRDE 360 LTKNQVSLWC LVKGFYPSDI AVEWESNGQP ENNYKTTPPV LDSDGSFFLY SKLTVDKSRW 420 QQGNVFSCSV MHEALHNHYT QKSLSLSPGK 450 Sequence Number (ID): 148 Length: 446 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..446 > note, Synthetic: 39A11 VH - source, 1..446 > mol_type, protein > organism, synthetic construct Residues: EVQLLESGGG LVQPGGSLRL SCAASGFTFS SYGMHWVRQA PGKGLEWVAS ISSSSGYIYY 60 ADSVKGRFTI SRDNSKNTLY LQMNSLRAED TAVYYCARAS SGMDVWGQGT TVTVSSASTK 120 GPSVFPLAPS SKSTSGGTAA LGCLVKDYFP EPVTVSWNSG ALTSGVHTFP AVLQSSGLYS 180 LSSVVTVPSS SLGTQTYICN VNHKPSNTKV DKKVEPKSCD KTHTCPPCPA PELLGGPSVF 240 LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR 300 VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVYTL PPCRDELTKN 360 QVSLWCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN 420 VFSCSVMHEA LHNHYTQKSL SLSPGK 446 Sequence Number (ID): 149 Length: 446 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..446 > note, Synthetic: 39A11 VH LS mutation - source, 1..446 > mol_type, protein > organism, synthetic construct Residues: EVQLLESGGG LVQPGGSLRL SCAASGFTFS SYGMHWVRQA PGKGLEWVAS ISSSSGYIYY 60 ADSVKGRFTI SRDNSKNTLY LQMNSLRAED TAVYYCARAS SGMDVWGQGT TVTVSSASTK 120 GPSVFPLAPS SKSTSGGTAA LGCLVKDYFP EPVTVSWNSG ALTSGVHTFP AVLQSSGLYS 180 LSSVVTVPSS SLGTQTYICN VNHKPSNTKV DKKVEPKSCD KTHTCPPCPA PELLGGPSVF 240 LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR 300 VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVYTL PPCRDELTKN 360 QVSLWCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN 420 VFSCSVLHEA LHSHYTQKSL SLSPGK 446 Sequence Number (ID): 150 Length: 446 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..446 > note, Synthetic: 3F2 VH - source, 1..446 > mol_type, protein > organism, synthetic construct Residues: QVQLVQSGAE VKKPGASVKV SCKASGYTFT AQYMYWVRQA PGQGLEWMGR INPTSGNTVY 60 AQKLQGRVTM TRDTSTSTVY MELSSLRSED TAVYYCARGI NWFDPWGQGT LVTVSSASTK 120 GPSVFPLAPS SKSTSGGTAA LGCLVKDYFP EPVTVSWNSG ALTSGVHTFP AVLQSSGLYS 180 LSSVVTVPSS SLGTQTYICN VNHKPSNTKV DKKVEPKSCD KTHTCPPCPA PELLGGPSVF 240 LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR 300 VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVYTL PPCRDELTKN 360 QVSLWCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN 420 VFSCSVMHEA LHNHYTQKSL SLSPGK 446 Sequence Number (ID): 151 Length: 446 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..446 > note, Synthetic: 3F2 VH LS mutation - source, 1..446 > mol_type, protein > organism, synthetic construct Residues: QVQLVQSGAE VKKPGASVKV SCKASGYTFT AQYMYWVRQA PGQGLEWMGR INPTSGNTVY 60 AQKLQGRVTM TRDTSTSTVY MELSSLRSED TAVYYCARGI NWFDPWGQGT LVTVSSASTK 120 GPSVFPLAPS SKSTSGGTAA LGCLVKDYFP EPVTVSWNSG ALTSGVHTFP AVLQSSGLYS 180 LSSVVTVPSS SLGTQTYICN VNHKPSNTKV DKKVEPKSCD KTHTCPPCPA PELLGGPSVF 240 LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR 300 VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVYTL PPCRDELTKN 360 QVSLWCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN 420 VFSCSVLHEA LHSHYTQKSL SLSPGK 446 Sequence Number (ID): 152 Length: 445 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..445 > note, Synthetic: DP47 HC1 - source, 1..445 > mol_type, protein > organism, synthetic construct Residues: EVQLLESGGG LVQPGGSLRL SCAASGFTFS SYAMSWVRQA PGKGLEWVSA ISGSGGSTYY 60 ADSVKGRFTI SRDNSKNTLY LQMNSLRAED TAVYYCAKGS GFDYWGQGTL VTVSSASTKG 120 PSVFPLAPSS KSTSGGTAAL GCLVKDYFPE PVTVSWNSGA LTSGVHTFPA VLQSSGLYSL 180 SSVVTVPSSS LGTQTYICNV NHKPSNTKVD KKVEPKSCDK THTCPPCPAP ELLGGPSVFL 240 FPPKPKDTLM ISRTPEVTCV VVDVSHEDPE VKFNWYVDGV EVHNAKTKPR EEQYNSTYRV 300 VSVLTVLHQD WLNGKEYKCK VSNKALPAPI EKTISKAKGQ PREPQVYTLP PCRDELTKNQ 360 VSLWCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSKLTV DKSRWQQGNV 420 FSCSVMHEAL HNHYTQKSLS LSPGK 445 Sequence Number (ID): 153 Length: 445 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..445 > note, Synthetic: LS mutation - source, 1..445 > mol_type, protein > organism, synthetic construct Residues: EVQLLESGGG LVQPGGSLRL SCAASGFTFS SYAMSWVRQA PGKGLEWVSA ISGSGGSTYY 60 ADSVKGRFTI SRDNSKNTLY LQMNSLRAED TAVYYCAKGS GFDYWGQGTL VTVSSASTKG 120 PSVFPLAPSS KSTSGGTAAL GCLVKDYFPE PVTVSWNSGA LTSGVHTFPA VLQSSGLYSL 180 SSVVTVPSSS LGTQTYICNV NHKPSNTKVD KKVEPKSCDK THTCPPCPAP ELLGGPSVFL 240 FPPKPKDTLM ISRTPEVTCV VVDVSHEDPE VKFNWYVDGV EVHNAKTKPR EEQYNSTYRV 300 VSVLTVLHQD WLNGKEYKCK VSNKALPAPI EKTISKAKGQ PREPQVYTLP PCRDELTKNQ 360 VSLWCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSKLTV DKSRWQQGNV 420 FSCSVLHEAL HSHYTQKSLS LSPGK 445 Sequence Number (ID): 154 Length: 659 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..659 > note, Synthetic: 20502 VH IL-15R-alpha sushi domain Linker IL-15 - source, 1..659 > mol_type, protein > organism, synthetic construct Residues: QLQLQESGPG LVKPSETLSL TCTVSGGSIK SGSYYWGWIR QPPGKGLEWI GNIYYSGSTY 60 YNPSLRSRVT ISVDTSKNQF SLKLSSVTAA DTAVYYCARE GSYPNQFDPW GQGTLVTVSS 120 ASTKGPSVFP LAPSSKSTSG GTAALGCLVK DYFPEPVTVS WNSGALTSGV HTFPAVLQSS 180 GLYSLSSVVT VPSSSLGTQT YICNVNHKPS NTKVDKKVEP KSCDKTHTCP PCPAPELLGG 240 PSVFLFPPKP KDTLMISRTP EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYN 300 STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VCTLPPSRDE 360 LTKNQVSLSC AVKGFYPSDI AVEWESNGQP ENNYKTTPPV LDSDGSFFLV SKLTVDKSRW 420 QQGNVFSCSV MHEALHNHYT QKSLSLSPGS CPPPMSVEHA DIWVKSYSLY SRERYICNSG 480 FKRKAGTSSL TECVLNKATN VAHWTTPSLK CIRDPALVHQ RPAPPSGGSG GGGSGGGSGG 540 GGSLQNWVNV ISDLKKIEDL IQSMHIDATL YTESDVHPSC KVTAMKCFLL ELQVISLESG 600 DASIHDTVES LIILANNSLS SNGNVTESGC KECEELEEKN IKEFLQSFVH IVQMFINTS 659 Sequence Number (ID): 155 Length: 655 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..655 > note, Synthetic: 39A11 VH IL-15R-alpha sushi domain Linker IL-15 - source, 1..655 > mol_type, protein > organism, synthetic construct Residues: EVQLLESGGG LVQPGGSLRL SCAASGFTFS SYGMHWVRQA PGKGLEWVAS ISSSSGYIYY 60 ADSVKGRFTI SRDNSKNTLY LQMNSLRAED TAVYYCARAS SGMDVWGQGT TVTVSSASTK 120 GPSVFPLAPS SKSTSGGTAA LGCLVKDYFP EPVTVSWNSG ALTSGVHTFP AVLQSSGLYS 180 LSSVVTVPSS SLGTQTYICN VNHKPSNTKV DKKVEPKSCD KTHTCPPCPA PELLGGPSVF 240 LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR 300 VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVCTL PPSRDELTKN 360 QVSLSCAVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLVSKLT VDKSRWQQGN 420 VFSCSVMHEA LHNHYTQKSL SLSPGSCPPP MSVEHADIWV KSYSLYSRER YICNSGFKRK 480 AGTSSLTECV LNKATNVAHW TTPSLKCIRD PALVHQRPAP PSGGSGGGGS GGGSGGGGSL 540 QNWVNVISDL KKIEDLIQSM HIDATLYTES DVHPSCKVTA MKCFLLELQV ISLESGDASI 600 HDTVESLIIL ANNSLSSNGN VTESGCKECE ELEEKNIKEF LQSFVHIVQM FINTS 655 Sequence Number (ID): 156 Length: 655 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..655 > note, Synthetic: 39A11 VH LS mutation IL-15R-alpha sushi domain Linker IL-15 - source, 1..655 > mol_type, protein > organism, synthetic construct Residues: EVQLLESGGG LVQPGGSLRL SCAASGFTFS SYGMHWVRQA PGKGLEWVAS ISSSSGYIYY 60 ADSVKGRFTI SRDNSKNTLY LQMNSLRAED TAVYYCARAS SGMDVWGQGT TVTVSSASTK 120 GPSVFPLAPS SKSTSGGTAA LGCLVKDYFP EPVTVSWNSG ALTSGVHTFP AVLQSSGLYS 180 LSSVVTVPSS SLGTQTYICN VNHKPSNTKV DKKVEPKSCD KTHTCPPCPA PELLGGPSVF 240 LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR 300 VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVCTL PPSRDELTKN 360 QVSLSCAVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLVSKLT VDKSRWQQGN 420 VFSCSVLHEA LHSHYTQKSL SLSPGSCPPP MSVEHADIWV KSYSLYSRER YICNSGFKRK 480 AGTSSLTECV LNKATNVAHW TTPSLKCIRD PALVHQRPAP PSGGSGGGGS GGGSGGGGSL 540 QNWVNVISDL KKIEDLIQSM HIDATLYTES DVHPSCKVTA MKCFLLELQV ISLESGDASI 600 HDTVESLIIL ANNSLSSNGN VTESGCKECE ELEEKNIKEF LQSFVHIVQM FINTS 655 Sequence Number (ID): 157 Length: 655 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..655 > note, Synthetic: 3F2 VH IL-15R-alpha sushi domain Linker IL-15 - source, 1..655 > mol_type, protein > organism, synthetic construct Residues: QVQLVQSGAE VKKPGASVKV SCKASGYTFT AQYMYWVRQA PGQGLEWMGR INPTSGNTVY 60 AQKLQGRVTM TRDTSTSTVY MELSSLRSED TAVYYCARGI NWFDPWGQGT LVTVSSASTK 120 GPSVFPLAPS SKSTSGGTAA LGCLVKDYFP EPVTVSWNSG ALTSGVHTFP AVLQSSGLYS 180 LSSVVTVPSS SLGTQTYICN VNHKPSNTKV DKKVEPKSCD KTHTCPPCPA PELLGGPSVF 240 LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR 300 VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVCTL PPSRDELTKN 360 QVSLSCAVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLVSKLT VDKSRWQQGN 420 VFSCSVMHEA LHNHYTQKSL SLSPGSCPPP MSVEHADIWV KSYSLYSRER YICNSGFKRK 480 AGTSSLTECV LNKATNVAHW TTPSLKCIRD PALVHQRPAP PSGGSGGGGS GGGSGGGGSL 540 QNWVNVISDL KKIEDLIQSM HIDATLYTES DVHPSCKVTA MKCFLLELQV ISLESGDASI 600 HDTVESLIIL ANNSLSSNGN VTESGCKECE ELEEKNIKEF LQSFVHIVQM FINTS 655 Sequence Number (ID): 158 Length: 655 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..655 > note, Synthetic: 3F2 VH LS mutation IL-15R-alpha sushi domain Linker IL-15 - source, 1..655 > mol_type, protein > organism, synthetic construct Residues: QVQLVQSGAE VKKPGASVKV SCKASGYTFT AQYMYWVRQA PGQGLEWMGR INPTSGNTVY 60 AQKLQGRVTM TRDTSTSTVY MELSSLRSED TAVYYCARGI NWFDPWGQGT LVTVSSASTK 120 GPSVFPLAPS SKSTSGGTAA LGCLVKDYFP EPVTVSWNSG ALTSGVHTFP AVLQSSGLYS 180 LSSVVTVPSS SLGTQTYICN VNHKPSNTKV DKKVEPKSCD KTHTCPPCPA PELLGGPSVF 240 LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR 300 VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVCTL PPSRDELTKN 360 QVSLSCAVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLVSKLT VDKSRWQQGN 420 VFSCSVLHEA LHSHYTQKSL SLSPGSCPPP MSVEHADIWV KSYSLYSRER YICNSGFKRK 480 AGTSSLTECV LNKATNVAHW TTPSLKCIRD PALVHQRPAP PSGGSGGGGS GGGSGGGGSL 540 QNWVNVISDL KKIEDLIQSM HIDATLYTES DVHPSCKVTA MKCFLLELQV ISLESGDASI 600 HDTVESLIIL ANNSLSSNGN VTESGCKECE ELEEKNIKEF LQSFVHIVQM FINTS 655 Sequence Number (ID): 159 Length: 654 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..654 > note, Synthetic: DP47 VH IL-15R-alpha sushi domain Linker IL-15 - source, 1..654 > mol_type, protein > organism, synthetic construct Residues: EVQLLESGGG LVQPGGSLRL SCAASGFTFS SYAMSWVRQA PGKGLEWVSA ISGSGGSTYY 60 ADSVKGRFTI SRDNSKNTLY LQMNSLRAED TAVYYCAKGS GFDYWGQGTL VTVSSASTKG 120 PSVFPLAPSS KSTSGGTAAL GCLVKDYFPE PVTVSWNSGA LTSGVHTFPA VLQSSGLYSL 180 SSVVTVPSSS LGTQTYICNV NHKPSNTKVD KKVEPKSCDK THTCPPCPAP ELLGGPSVFL 240 FPPKPKDTLM ISRTPEVTCV VVDVSHEDPE VKFNWYVDGV EVHNAKTKPR EEQYNSTYRV 300 VSVLTVLHQD WLNGKEYKCK VSNKALPAPI EKTISKAKGQ PREPQVCTLP PSRDELTKNQ 360 VSLSCAVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLVSKLTV DKSRWQQGNV 420 FSCSVMHEAL HNHYTQKSLS LSPGSCPPPM SVEHADIWVK SYSLYSRERY ICNSGFKRKA 480 GTSSLTECVL NKATNVAHWT TPSLKCIRDP ALVHQRPAPP SGGSGGGGSG GGSGGGGSLQ 540 NWVNVISDLK KIEDLIQSMH IDATLYTESD VHPSCKVTAM KCFLLELQVI SLESGDASIH 600 DTVESLIILA NNSLSSNGNV TESGCKECEE LEEKNIKEFL QSFVHIVQMF INTS 654 Sequence Number (ID): 160 Length: 654 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..654 > note, Synthetic: LS mutation IL-15R-alpha sushi domain Linker IL-15 - source, 1..654 > mol_type, protein > organism, synthetic construct Residues: EVQLLESGGG LVQPGGSLRL SCAASGFTFS SYAMSWVRQA PGKGLEWVSA ISGSGGSTYY 60 ADSVKGRFTI SRDNSKNTLY LQMNSLRAED TAVYYCAKGS GFDYWGQGTL VTVSSASTKG 120 PSVFPLAPSS KSTSGGTAAL GCLVKDYFPE PVTVSWNSGA LTSGVHTFPA VLQSSGLYSL 180 SSVVTVPSSS LGTQTYICNV NHKPSNTKVD KKVEPKSCDK THTCPPCPAP ELLGGPSVFL 240 FPPKPKDTLM ISRTPEVTCV VVDVSHEDPE VKFNWYVDGV EVHNAKTKPR EEQYNSTYRV 300 VSVLTVLHQD WLNGKEYKCK VSNKALPAPI EKTISKAKGQ PREPQVCTLP PSRDELTKNQ 360 VSLSCAVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLVSKLTV DKSRWQQGNV 420 FSCSVLHEAL HSHYTQKSLS LSPGSCPPPM SVEHADIWVK SYSLYSRERY ICNSGFKRKA 480 GTSSLTECVL NKATNVAHWT TPSLKCIRDP ALVHQRPAPP SGGSGGGGSG GGSGGGGSLQ 540 NWVNVISDLK KIEDLIQSMH IDATLYTESD VHPSCKVTAM KCFLLELQVI SLESGDASIH 600 DTVESLIILA NNSLSSNGNV TESGCKECEE LEEKNIKEFL QSFVHIVQMF INTS 654 Sequence Number (ID): 161 Length: 282 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..282 > note, misc_feature - human B7-H4 (NCBI accession #: NP_078902) signal peptide IgV domain IgC domain transmembrane region - source, 1..282 > mol_type, protein > organism, Homo sapiens Residues: MASLGQILFW SIISIIIILA GAIALIIGFG ISGRHSITVT TVASAGNIGE DGILSCTFEP 60 DIKLSDIVIQ WLKEGVLGLV HEFKEGKDEL SEQDEMFRGR TAVFADQVIV GNASLRLKNV 120 QLTDAGTYKC YIITSKGKGN ANLEYKTGAF SMPEVNVDYN ASSETLRCEA PRWFPQPTVV 180 WASQVDQGAN FSEVSNTSFE LNSENVTMKV VSVLYNVTIN NTYSCMIEND IAKATGDIKV 240 TESEIKRRSH LQLLNSKASL CVSSFFAISW ALLPLSPYLM LK 282 Sequence Number (ID): 162 Length: 283 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..283 > note, misc_feature - Murine B7-H4 (NCBI accession#: Q7TSP5, Phe29-Pro258) signal peptide IgV domain IgC domain transmembrane region - source, 1..283 > mol_type, protein > organism, Mus musculus Residues: MASLGQIIFW SIINIIIILA GAIALIIGFG ISGKHFITVT TFTSAGNIGE DGTLSCTFEP 60 DIKLNGIVIQ WLKEGIKGLV HEFKEGKDDL SQQHEMFRGR TAVFADQVVV GNASLRLKNV 120 QLTDAGTYTC YIRTSKGKGN ANLEYKTGAF SMPEINVDYN ASSESLRCEA PRWFPQPTVA 180 WASQVDQGAN FSEVSNTSFE LNSENVTMKV VSVLYNVTIN NTYSCMIEND IAKATGDIKV 240 TDSEVKRRSQ LQLLNSGPSP CVFSSAFVAG WALLSLSCCL MLR 283 Sequence Number (ID): 163 Length: 330 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..330 > note, misc_feature - IgG1 Fc (NCBI accession #: P01857) Pro100-Lys330 underlined - source, 1..330 > mol_type, protein > organism, Homo sapiens Residues: ASTKGPSVFP LAPSSKSTSG GTAALGCLVK DYFPEPVTVS WNSGALTSGV HTFPAVLQSS 60 GLYSLSSVVT VPSSSLGTQT YICNVNHKPS NTKVDKKVEP KSCDKTHTCP PCPAPELLGG 120 PSVFLFPPKP KDTLMISRTP EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYN 180 STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSRDE 240 LTKNQVSLTC LVKGFYPSDI AVEWESNGQP ENNYKTTPPV LDSDGSFFLY SKLTVDKSRW 300 QQGNVFSCSV MHEALHNHYT QKSLSLSPGK 330 Sequence Number (ID): 164 Length: 162 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..162 > note, misc_feature - Full-length human Il-15 (NCBI accession #: P40933) mature protein - source, 1..162 > mol_type, protein > organism, Homo sapiens Residues: MRISKPHLRS ISIQCYLCLL LNSHFLTEAG IHVFILGCFS AGLPKTEANW VNVISDLKKI 60 EDLIQSMHID ATLYTESDVH PSCKVTAMKC FLLELQVISL ESGDASIHDT VENLIILANN 120 SLSSNGNVTE SGCKECEELE EKNIKEFLQS FVHIVQMFIN TS 162 Sequence Number (ID): 165 Length: 114 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..114 > note, misc_feature - Human IL-15 (mature protein) - source, 1..114 > mol_type, protein > organism, Homo sapiens Residues: NWVNVISDLK KIEDLIQSMH IDATLYTESD VHPSCKVTAM KCFLLELQVI SLESGDASIH 60 DTVENLIILA NNSLSSNGNV TESGCKECEE LEEKNIKEFL QSFVHIVQMF INTS 114 Sequence Number (ID): 166 Length: 114 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..114 > note, misc_feature - Human IL-15 N65S (mature protein) - source, 1..114 > mol_type, protein > organism, Homo sapiens Residues: NWVNVISDLK KIEDLIQSMH IDATLYTESD VHPSCKVTAM KCFLLELQVI SLESGDASIH 60 DTVESLIILA NNSLSSNGNV TESGCKECEE LEEKNIKEFL QSFVHIVQMF INTS 114 Sequence Number (ID): 167 Length: 61 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..61 > note, misc_feature - IL-15R-alpha sushi domain (residues 33-93 of NCBI accession #: EAW86418.1) - source, 1..61 > mol_type, protein > organism, Homo sapiens Residues: CPPPMSVEHA DIWVKSYSLY SRERYICNSG FKRKAGTSSL TECVLNKATN VAHWTTPSLK 60 C 61 Sequence Number (ID): 168 Length: 20 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..20 > note, Synthetic: Artificial sequence - source, 1..20 > mol_type, protein > organism, synthetic construct Residues: SGGSGGGGSG GGSGGGGSLQ 20 Sequence Number (ID): 169 Length: 209 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..209 > note, Synthetic: IL-15R-alpha sushi domain + linker + Il-15 N65S - source, 1..209 > mol_type, protein > organism, synthetic construct Residues: CPPPMSVEHA DIWVKSYSLY SRERYICNSG FKRKAGTSSL TECVLNKATN VAHWTTPSLK 60 CIRDPALVHQ RPAPPSGGSG GGGSGGGSGG GGSLQNWVNV ISDLKKIEDL IQSMHIDATL 120 YTESDVHPSC KVTAMKCFLL ELQVISLESG DASIHDTVES LIILANNSLS SNGNVTESGC 180 KECEELEEKN IKEFLQSFVH IVQMFINTS 209 Sequence Number (ID): 170 Length: 34 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..34 > note, Synthetic: Artificial sequence - source, 1..34 > mol_type, protein > organism, synthetic construct Residues: IRDPALVHQR PAPPSGGSGG GGSGGGSGGG GSLQ 34 Sequence Number (ID): 171 Length: 14 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..14 > note, Synthetic: Artificial sequence - source, 1..14 > mol_type, protein > organism, synthetic construct Residues: IRDPALVHQR PAPP 14 Sequence Number (ID): 172 Length: 5 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..5 > note, Synthetic: 3F2 CDR1H - source, 1..5 > mol_type, protein > organism, synthetic construct Residues: AQYMY 5 Sequence Number (ID): 173 Length: 17 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..17 > note, Synthetic: 3F2 CDR2H - source, 1..17 > mol_type, protein > organism, synthetic construct Residues: RINPTSGNTV YAQKLQG 17 Sequence Number (ID): 174 Length: 7 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..7 > note, Synthetic: 3F2 CDR3H - source, 1..7 > mol_type, protein > organism, synthetic construct Residues: GINWFDP 7 Sequence Number (ID): 175 Length: 7 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..7 > note, Synthetic: 50A10 CDR1L - source, 1..7 > mol_type, protein > organism, synthetic construct Residues: SQDISNY 7 Sequence Number (ID): 176 Residues: 000 Sequence Number (ID): 177 Length: 6 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..6 > note, Synthetic: 50A10 CDR3L - source, 1..6 > mol_type, protein > organism, synthetic construct Residues: SYRSPF 6 Sequence Number (ID): 178 Length: 8 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..8 > note, Synthetic: 3F2 CDR1H - source, 1..8 > mol_type, protein > organism, synthetic construct Residues: GYTFTAQY 8 Sequence Number (ID): 179 Length: 8 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..8 > note, Synthetic: 3F2 CDR2H - source, 1..8 > mol_type, protein > organism, synthetic construct Residues: INPTSGNT 8 Sequence Number (ID): 180 Length: 9 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..9 > note, Synthetic: 3F2 CDR3H - source, 1..9 > mol_type, protein > organism, synthetic construct Residues: ARGINWFDP 9 Sequence Number (ID): 181 Length: 7 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..7 > note, Synthetic: 50A10 CDR1L - source, 1..7 > mol_type, protein > organism, synthetic construct Residues: SQDISNY 7 Sequence Number (ID): 182 Residues: 000 Sequence Number (ID): 183 Length: 6 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..6 > note, Synthetic: 50A10 CDR3L - source, 1..6 > mol_type, protein > organism, synthetic construct Residues: SYRSPF 6 Sequence Number (ID): 184 Length: 7 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..7 > note, Synthetic: 3F2 CDR1H - source, 1..7 > mol_type, protein > organism, synthetic construct Residues: GYTFTAQ 7 Sequence Number (ID): 185 Length: 4 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..4 > note, Synthetic: 3F2 CDR2H - source, 1..4 > mol_type, protein > organism, synthetic construct Residues: PTSG 4 Sequence Number (ID): 186 Length: 5 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..5 > note, Synthetic: 3F2 CDR3H - source, 1..5 > mol_type, protein > organism, synthetic construct Residues: INWFD 5 Sequence Number (ID): 187 Length: 11 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..11 > note, Synthetic: 50A10 CDR1L - source, 1..11 > mol_type, protein > organism, synthetic construct Residues: QASQDISNYI N 11 Sequence Number (ID): 188 Length: 7 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..7 > note, Synthetic: 50A10 CDR2L - source, 1..7 > mol_type, protein > organism, synthetic construct Residues: AASRLQS 7 Sequence Number (ID): 189 Length: 9 Molecule Type: AA Features Location/Qualifiers: - REGION, 1..9 > note, Synthetic: 50A10 CDR3L - source, 1..9 > mol_type, protein > organism, synthetic construct Residues: QQSYRSPFT 9 END