14620-563-228 US 63/297.436 2022-01-07 JOHNSON & JOHNSON ENTERPRISE INNOVATION INC. JOHNSON & JOHNSON ENTERPRISE INNOVATION INC. MATERIALS AND METHODS OF IL-1BETA BINDING PROTEINS MATERIALES Y MÉTODOS DE PROTEÍNAS DE UNIÓN A IL-1BETA 110 450 AA PAT source 1..450 mol_type protein proteína note 05H21A HC 05H21A HC organism synthetic construct constructo sintético QVTLRESGPALVKPTQTLTLTCTFSGFSLSTSGMWVSWIRQPPGKALEWLALIDWGDDKYYTTSLKTRLTISKDTSKNQVVLTMTNMDPVDTATYYCARMREGSRAFDIWGQGTVVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLYITREPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 216 AA PAT source 1..216 mol_type protein proteína note 05H21A LC 05H21A LC organism synthetic construct constructo sintético QSVLTQPPSVSEAPRQRVTISCSGSSSNIGDNAVNWYQQLPGKAPKLLIYNDDLLSSGVSDRFSGSKSGTSASLAISGLQSEDEADYYCAAWDDSLNGPVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS 449 AA PAT source 1..449 mol_type protein proteína note 15N14A HC 15N14A HC organism synthetic construct constructo sintético QVQLQESGPGLVKPSETLSLTCTVSGGSISSYYWTWIRQPAGKGLEWIGRIDSSGSSKYNPTLKSRVTMSVDTSKNQFSLKLSSVTAADTAVYYCARGDSGYDWAFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLYITREPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 221 AA PAT source 1..221 mol_type protein proteína note 15N14A LC 15N14A LC organism synthetic construct constructo sintético QAVLTQPSSLSASPGASASLTCTLRSGINVGTYRIYWYQQKPGSPPQYLLSYKSDSDKQQGSGVPSRFSGSKDASANVGILLISGLQSEDEADYYCMIWHSSAWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS 448 AA PAT source 1..448 mol_type protein proteína note 08F17A HC 08F17A HC organism synthetic construct constructo sintético EVQLVESGGGLVTPGGSLRLSCAASGFTFSGYSMNWVRQAPGKGLEWVSSISSSSGYIYYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCAREYWGSGFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLYITREPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 214 AA PAT source 1..214 mol_type protein proteína note 08F17A LC 08F17A LC organism synthetic construct constructo sintético DIQMTQSPSSLSASVGDRVTITCRASQGISYYLAWYQQKPGKVPKLLISAEFTLQSGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCQKYNTAPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 120 AA PAT source 1..120 mol_type protein proteína note 05H21A VH 05H21A VH organism synthetic construct constructo sintético QVTLRESGPALVKPTQTLTLTCTFSGFSLSTSGMWVSWIRQPPGKALEWLALIDWGDDKYYTTSLKTRLTISKDTSKNQVVLTMTNMDPVDTATYYCARMREGSRAFDIWGQGTVVTVSS 110 AA PAT source 1..110 mol_type protein proteína note 05H21A VL 05H21A VL organism synthetic construct constructo sintético QSVLTQPPSVSEAPRQRVTISCSGSSSNIGDNAVNWYQQLPGKAPKLLIYNDDLLSSGVSDRFSGSKSGTSASLAISGLQSEDEADYYCAAWDDSLNGPVFGGGTKLTVL 119 AA PAT source 1..119 mol_type protein proteína note 15N14A VH 15N14A VH organism synthetic construct constructo sintético QVQLQESGPGLVKPSETLSLTCTVSGGSISSYYWTWIRQPAGKGLEWIGRIDSSGSSKYNPTLKSRVTMSVDTSKNQFSLKLSSVTAADTAVYYCARGDSGYDWAFDYWGQGTLVTVSS 115 AA PAT source 1..115 mol_type protein proteína note 15N14A VL 15N14A VL organism synthetic construct constructo sintético QAVLTQPSSLSASPGASASLTCTLRSGINVGTYRIYWYQQKPGSPPQYLLSYKSDSDKQQGSGVPSRFSGSKDASANVGILLISGLQSEDEADYYCMIWHSSAWVFGGGTKLTVL 118 AA PAT source 1..118 mol_type protein proteína note 08F17A VH 08F17A VH organism synthetic construct constructo sintético EVQLVESGGGLVTPGGSLRLSCAASGFTFSGYSMNWVRQAPGKGLEWVSSISSSSGYIYYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCAREYWGSGFDYWGQGTLVTVSS 107 AA PAT source 1..107 mol_type protein proteína note 08F17A VL 08F17A VL organism synthetic construct constructo sintético DIQMTQSPSSLSASVGDRVTITCRASQGISYYLAWYQQKPGKVPKLLISAEFTLQSGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCQKYNTAPRTFGQGTKVEIK 7 AA PAT source 1..7 mol_type protein proteína note 05H21A HCDR1 (Kabat) HCDR1 de 05H21A (Kabat) organism synthetic construct constructo sintético TSGMWVS 16 AA PAT source 1..16 mol_type protein proteína note 05H21A HCDR2 (Kabat) HCDR2 de 05H21A (Kabat) organism synthetic construct constructo sintético LIDWGDDKYYTTSLKT 10 AA PAT source 1..10 mol_type protein proteína note 05H21A HCDR3 (Kabat) HCDR3 de 05H21A (Kabat) organism synthetic construct constructo sintético MREGSRAFDI 13 AA PAT source 1..13 mol_type protein proteína note 05H21A LCDR1 (Kabat) LCDR1 de 05H21A (Kabat) organism synthetic construct constructo sintético SGSSSNIGDNAVN 7 AA PAT source 1..7 mol_type protein proteína note 05H21A LCDR2 (Kabat) LCDR2 de 05H21A (Kabat) organism synthetic construct constructo sintético NDDLLSS 11 AA PAT source 1..11 mol_type protein proteína note 05H21A LCDR3 (Kabat) LCDR3 de 05H21A (Kabat) organism synthetic construct constructo sintético AAWDDSLNGPV 5 AA PAT source 1..5 mol_type protein proteína note 15N14A HCDR1 (Kabat) HCDR1 de 15N14A (Kabat) organism synthetic construct constructo sintético SYYWT 16 AA PAT source 1..16 mol_type protein proteína note 15N14A HCDR2 (Kabat) HCDR2 de 15N14A (Kabat) organism synthetic construct constructo sintético RIDSSGSSKYNPTLKS 11 AA PAT source 1..11 mol_type protein proteína note 15N14A HCDR3 (Kabat) HCDR3 de 15N14A (Kabat) organism synthetic construct constructo sintético GDSGYDWAFDY 14 AA PAT source 1..14 mol_type protein proteína note 15N14A LCDR1 (Kabat) LCDR1 de 15N14A (Kabat) organism synthetic construct constructo sintético TLRSGINVGTYRIY 11 AA PAT source 1..11 mol_type protein proteína note 15N14A LCDR2 (Kabat) LCDR2 de 15N14A (Kabat) organism synthetic construct constructo sintético YKSDSDKQQGS 9 AA PAT source 1..9 mol_type protein proteína note 15N14A LCDR3 (Kabat) LCDR3 de 15N14A (Kabat) organism synthetic construct constructo sintético MIWHSSAWV 5 AA PAT source 1..5 mol_type protein proteína note 08F17A HCDR1 (Kabat) HCDR1 de 08F17A (Kabat) organism synthetic construct constructo sintético GYSMN 17 AA PAT source 1..17 mol_type protein proteína note 08F17A HCDR2 (Kabat) HCDR2 de 08F17A (Kabat) organism synthetic construct constructo sintético SISSSSGYIYYADSVKG 9 AA PAT source 1..9 mol_type protein proteína note 08F17A HCDR3 (Kabat) HCDR3 de 08F17A (Kabat) organism synthetic construct constructo sintético EYWGSGFDY 11 AA PAT source 1..11 mol_type protein proteína note 08F17A LCDR1 (Kabat) LCDR1 de 08F17A (Kabat) organism synthetic construct constructo sintético RASQGISYYLA 7 AA PAT source 1..7 mol_type protein proteína note 08F17A LCDR2 (Kabat) LCDR2 de 08F17A (Kabat) organism synthetic construct constructo sintético AEFTLQS 9 AA PAT source 1..9 mol_type protein proteína note 08F17A LCDR3 (Kabat) LCDR3 de 08F17A (Kabat) organism synthetic construct constructo sintético QKYNTAPRT 9 AA PAT source 1..9 mol_type protein proteína note 05H21A HCDR1 (Chothia) HCDR1 de 05H21A (Chothia) organism synthetic construct constructo sintético GFSLSTSGM 5 AA PAT source 1..5 mol_type protein proteína note 05H21A HCDR2 (Chothia) HCDR2 de 05H21A (Chothia) organism synthetic construct constructo sintético DWGDD 10 AA PAT source 1..10 mol_type protein proteína note 05H21A HCDR3 (Chothia) HCDR3 de 05H21A (Chothia) organism synthetic construct constructo sintético MREGSRAFDI 13 AA PAT source 1..13 mol_type protein proteína note 05H21A LCDR1 (Chothia) LCDR1 de 05H21A (Chothia) organism synthetic construct constructo sintético SGSSSNIGDNAVN 7 AA PAT source 1..7 mol_type protein proteína note 05H21A LCDR2 (Chothia) LCDR2 de 05H21A (Chothia) organism synthetic construct constructo sintético NDDLLSS 11 AA PAT source 1..11 mol_type protein proteína note 05H21A LCDR3 (Chothia) LCDR3 de 05H21A (Chothia) organism synthetic construct constructo sintético AAWDDSLNGPV 7 AA PAT source 1..7 mol_type protein proteína note 15N14A HCDR1 (Chothia) HCDR1 de 15N14A (Chothia) organism synthetic construct constructo sintético GGSISSY 5 AA PAT source 1..5 mol_type protein proteína note 15N14A HCDR2 (Chothia) HCDR2 de 15N14A (Chothia) organism synthetic construct constructo sintético DSSGS 11 AA PAT source 1..11 mol_type protein proteína note 15N14A HCDR3 (Chothia) HCDR3 de 15N14A (Chothia) organism synthetic construct constructo sintético GDSGYDWAFDY 14 AA PAT source 1..14 mol_type protein proteína note 15N14A LCDR1 (Chothia) LCDR1 de 15N14A (Chothia) organism synthetic construct constructo sintético TLRSGINVGTYRIY 11 AA PAT source 1..11 mol_type protein proteína note 15N14A LCDR2 (Chothia) LCDR2 de 15N14A (Chothia) organism synthetic construct constructo sintético YKSDSDKQQGS 9 AA PAT source 1..9 mol_type protein proteína note 15N14A LCDR3 (Chothia) LCDR3 de 15N14A (Chothia) organism synthetic construct constructo sintético MIWHSSAWV 7 AA PAT source 1..7 mol_type protein proteína note 08F17A HCDR1 (Chothia) HCDR1 de 08F17A (Chothia) organism synthetic construct constructo sintético GFTFSGY 6 AA PAT source 1..6 mol_type protein proteína note 08F17A HCDR2 (Chothia) HCDR2 de 08F17A (Chothia) organism synthetic construct constructo sintético SSSSGY 9 AA PAT source 1..9 mol_type protein proteína note 08F17A HCDR3 (Chothia) HCDR3 de 08F17A (Chothia) organism synthetic construct constructo sintético EYWGSGFDY 11 AA PAT source 1..11 mol_type protein proteína note 08F17A LCDR1 (Chothia) LCDR1 de 08F17A (Chothia) organism synthetic construct constructo sintético RASQGISYYLA 7 AA PAT source 1..7 mol_type protein proteína note 08F17A LCDR2 (Chothia) LCDR2 de 08F17A (Chothia) organism synthetic construct constructo sintético AEFTLQS 9 AA PAT source 1..9 mol_type protein proteína note 08F17A LCDR3 (Chothia) LCDR3 de 08F17A (Chothia) organism synthetic construct constructo sintético QKYNTAPRT 12 AA PAT source 1..12 mol_type protein proteína note 05H21A HCDR1 (AbM) HCDR1 de 05H21A (AbM) organism synthetic construct constructo sintético GFSLSTSGMWVS 9 AA PAT source 1..9 mol_type protein proteína note 05H21A HCDR2 (AbM) HCDR2 de 05H21A (AbM) organism synthetic construct constructo sintético LIDWGDDKY 10 AA PAT source 1..10 mol_type protein proteína note 05H21A HCDR3 (AbM) HCDR3 de 05H21A (AbM) organism synthetic construct constructo sintético MREGSRAFDI 13 AA PAT source 1..13 mol_type protein proteína note 05H21A LCDR1 (AbM) LCDR1 de 05H21A (AbM) organism synthetic construct constructo sintético SGSSSNIGDNAVN 7 AA PAT source 1..7 mol_type protein proteína note 05H21A LCDR2 (AbM) LCDR2 de 05H21A (AbM) organism synthetic construct constructo sintético NDDLLSS 11 AA PAT source 1..11 mol_type protein proteína note 05H21A LCDR3 (AbM) LCDR3 de 05H21A (AbM) organism synthetic construct constructo sintético AAWDDSLNGPV 10 AA PAT source 1..10 mol_type protein proteína note 15N14A HCDR1 (AbM) HCDR1 de 15N14A (AbM) organism synthetic construct constructo sintético GGSISSYYWT 9 AA PAT source 1..9 mol_type protein proteína note 15N14A HCDR2 (AbM) HCDR2 de 15N14A (AbM) organism synthetic construct constructo sintético RIDSSGSSK 11 AA PAT source 1..11 mol_type protein proteína note 15N14A HCDR3 (AbM) HCDR3 de 15N14A (AbM) organism synthetic construct constructo sintético GDSGYDWAFDY 14 AA PAT source 1..14 mol_type protein proteína note 15N14A LCDR1 (AbM) LCDR1 de 15N14A (AbM) organism synthetic construct constructo sintético TLRSGINVGTYRIY 11 AA PAT source 1..11 mol_type protein proteína note 15N14A LCDR2 (AbM) LCDR2 de 15N14A (AbM) organism synthetic construct constructo sintético YKSDSDKQQGS 9 AA PAT source 1..9 mol_type protein proteína note 15N14A LCDR3 (AbM) LCDR3 de 15N14A (AbM) organism synthetic construct constructo sintético MIWHSSAWV 10 AA PAT source 1..10 mol_type protein proteína note 08F17A HCDR1 (AbM) HCDR1 de 08F17A (AbM) organism synthetic construct constructo sintético GFTFSGYSMN 10 AA PAT source 1..10 mol_type protein proteína note 08F17A HCDR2 (AbM) HCDR2 de 08F17A (AbM) organism synthetic construct constructo sintético SISSSSGYIY 9 AA PAT source 1..9 mol_type protein proteína note 08F17A HCDR3 (AbM) HCDR3 de 08F17A (AbM) organism synthetic construct constructo sintético EYWGSGFDY 11 AA PAT source 1..11 mol_type protein proteína note 08F17A LCDR1 (AbM) LCDR1 de 08F17A (AbM) organism synthetic construct constructo sintético RASQGISYYLA 7 AA PAT source 1..7 mol_type protein proteína note 08F17A LCDR2 (AbM) LCDR2 de 08F17A (AbM) organism synthetic construct constructo sintético AEFTLQS 9 AA PAT source 1..9 mol_type protein proteína note 08F17A LCDR3 (AbM) LCDR3 de 08F17A (AbM) organism synthetic construct constructo sintético QKYNTAPRT 8 AA PAT source 1..8 mol_type protein proteína note 05H21A HCDR1 (Contact) HCDR1 de 05H21A (Contact) organism synthetic construct constructo sintético STSGMWVS 12 AA PAT source 1..12 mol_type protein proteína note 05H21A HCDR2 (Contact) HCDR2 de 05H21A (Contact) organism synthetic construct constructo sintético WLALIDWGDDKY 11 AA PAT source 1..11 mol_type protein proteína note 05H21A HCDR3 (Contact) HCDR3 de 05H21A (Contact) organism synthetic construct constructo sintético ARMREGSRAFD 9 AA PAT source 1..9 mol_type protein proteína note 05H21A LCDR1 (Contact) LCDR1 de 05H21A (Contact) organism synthetic construct constructo sintético IGDNAVNWY 10 AA PAT source 1..10 mol_type protein proteína note 05H21A LCDR2 (Contact) LCDR2 de 05H21A (Contact) organism synthetic construct constructo sintético LLIYNDDLLS 10 AA PAT source 1..10 mol_type protein proteína note 05H21A LCDR3 (Contact) LCDR3 de 05H21A (Contact) organism synthetic construct constructo sintético AAWDDSLNGP 6 AA PAT source 1..6 mol_type protein proteína note 15N14A HCDR1 (Contact) HCDR1 de 15N14A (Contact) organism synthetic construct constructo sintético SSYYWT 12 AA PAT source 1..12 mol_type protein proteína note 15N14A HCDR2 (Contact) HCDR2 de 15N14A (Contact) organism synthetic construct constructo sintético WIGRIDSSGSSK 12 AA PAT source 1..12 mol_type protein proteína note 15N14A HCDR3 (Contact) HCDR3 de 15N14A (Contact) organism synthetic construct constructo sintético ARGDSGYDWAFD 10 AA PAT source 1..10 mol_type protein proteína note 15N14A LCDR1 (Contact) LCDR1 de 15N14A (Contact) organism synthetic construct constructo sintético NVGTYRIYWY 14 AA PAT source 1..14 mol_type protein proteína note 15N14A LCDR2 (Contact) LCDR2 de 15N14A (Contact) organism synthetic construct constructo sintético YLLSYKSDSDKQQG 8 AA PAT source 1..8 mol_type protein proteína note 15N14A LCDR3 (Contact) LCDR3 de 15N14A (Contact) organism synthetic construct constructo sintético MIWHSSAW 6 AA PAT source 1..6 mol_type protein proteína note 08F17A HCDR1 (Contact) HCDR1 de 08F17A (Contact) organism synthetic construct constructo sintético SGYSMN 13 AA PAT source 1..13 mol_type protein proteína note 08F17A HCDR2 (Contact) HCDR2 de 08F17A (Contact) organism synthetic construct constructo sintético WVSSISSSSGYIY 10 AA PAT source 1..10 mol_type protein proteína note 08F17A HCDR3 (Contact) HCDR3 de 08F17A (Contact) organism synthetic construct constructo sintético AREYWGSGFD 7 AA PAT source 1..7 mol_type protein proteína note 08F17A LCDR1 (Contact) LCDR1 de 08F17A (Contact) organism synthetic construct constructo sintético SYYLAWY 10 AA PAT source 1..10 mol_type protein proteína note 08F17A LCDR2 (Contact) LCDR2 de 08F17A (Contact) organism synthetic construct constructo sintético LLISAEFTLQ 8 AA PAT source 1..8 mol_type protein proteína note 08F17A LCDR3 (Contact) LCDR3 de 08F17A (Contact) organism synthetic construct constructo sintético QKYNTAPR 10 AA PAT source 1..10 mol_type protein proteína note 05H21A HCDR1 (IMGT) HCDR1 de 05H21A (IMGT) organism synthetic construct constructo sintético GFSLSTSGMW 7 AA PAT source 1..7 mol_type protein proteína note 05H21A HCDR2 (IMGT) HCDR2 de 05H21A (IMGT) organism synthetic construct constructo sintético IDWGDDK 12 AA PAT source 1..12 mol_type protein proteína note 05H21A HCDR3 (IMGT) HCDR3 de 05H21A (IMGT) organism synthetic construct constructo sintético ARMREGSRAFDI 8 AA PAT source 1..8 mol_type protein proteína note 05H21A LCDR1 (IMGT) LCDR1 de 05H21A (IMGT) organism synthetic construct constructo sintético SSNIGDNA 000 11 AA PAT source 1..11 mol_type protein proteína note 05H21A LCDR3 (IMGT) LCDR3 de 05H21A (IMGT) organism synthetic construct constructo sintético AAWDDSLNGPV 8 AA PAT source 1..8 mol_type protein proteína note 15N14A HCDR1 (IMGT) HCDR1 de 15N14A (IMGT) organism synthetic construct constructo sintético GGSISSYY 7 AA PAT source 1..7 mol_type protein proteína note 15N14A HCDR2 (IMGT) HCDR2 de 15N14A (IMGT) organism synthetic construct constructo sintético IDSSGSS 13 AA PAT source 1..13 mol_type protein proteína note 15N14A HCDR3 (IMGT) HCDR3 de 15N14A (IMGT) organism synthetic construct constructo sintético ARGDSGYDWAFDY 9 AA PAT source 1..9 mol_type protein proteína note 15N14A LCDR1 (IMGT) LCDR1 de 15N14A (IMGT) organism synthetic construct constructo sintético SGINVGTYR 7 AA PAT source 1..7 mol_type protein proteína note 15N14A LCDR2 (IMGT) LCDR2 de 15N14A (IMGT) organism synthetic construct constructo sintético YKSDSDK 9 AA PAT source 1..9 mol_type protein proteína note 15N14A LCDR3 (IMGT) LCDR3 de 15N14A (IMGT) organism synthetic construct constructo sintético MIWHSSAWV 8 AA PAT source 1..8 mol_type protein proteína note 08F17A HCDR1 (IMGT) HCDR1 de 08F17A (IMGT) organism synthetic construct constructo sintético GFTFSGYS 8 AA PAT source 1..8 mol_type protein proteína note 08F17A HCDR2 (IMGT) HCDR2 de 08F17A (IMGT) organism synthetic construct constructo sintético ISSSSGYI 11 AA PAT source 1..11 mol_type protein proteína note 08F17A HCDR3 (IMGT) HCDR3 de 08F17A (IMGT) organism synthetic construct constructo sintético AREYWGSGFDY 6 AA PAT source 1..6 mol_type protein proteína note 08F17A LCDR1 (IMGT) LCDR1 de 08F17A (IMGT) organism synthetic construct constructo sintético QGISYY 000 9 AA PAT source 1..9 mol_type protein proteína note 08F17A LCDR3 (IMGT) LCDR3 de 08F17A (IMGT) organism synthetic construct constructo sintético QKYNTAPRT 648 ADN PAT source 1..648 mol_type other DNA otro ADN note 05H21A LC 05H21A LC organism synthetic construct constructo sintético cagtctgtgctgacccagcctccatctgtgtctgaggcccctagacagagagtgaccatctcctgctccggctcctcctctaacatcggcgataacgccgtgaactggtatcagcagctgcctggcaaggcccctaaactgctgatctacaacgacgacctgctgtcctctggcgtgtccgacagattctccggctctaagtctggcacctccgccagcctggctatctctggattgcagtctgaggacgaggccgactactactgtgccgcctgggacgattctctgaacggccctgtttttggcggaggcaccaagctgacagtcctgggtcagcccaaggctgcacccagtgtcactctgttcccgccctcctctgaggagcttcaagccaacaaggccacactggtgtgtctcataagtgacttctacccgggagccgtgacagtggcctggaaggccgatagcagccccgtcaaggcgggagtcgaaaccaccacaccctccaaacaaagcaacaacaagtacgcggccagcagctatctgagcctgacgcctgagcagtggaagtcccacagaagctacagctgccaggtcacgcatgaagggagcaccgtggagaagacagtggcccctacagaatgttca 1350 ADN PAT source 1..1350 mol_type other DNA otro ADN note 05H21A HC 05H21A HC organism synthetic construct constructo sintético caagtgaccctgagagagtctggacccgctctggtcaagcccacacagaccctgacactgacctgcaccttctccggcttctccctgtccacctctggaatgtgggtgtcctggatcagacagcctcctggcaaggcactggaatggctggctctgatcgattggggcgacgacaagtactacaccaccagcctgaaaacccggctgaccatctccaaggacacctccaagaaccaggtggtgctgaccatgaccaacatggaccctgtggacaccgccacctactactgcgccagaatgagagagggatccagagccttcgatatctggggccagggaaccgtggtcaccgtttcttctgcctccaccaagggcccatcggtcttccccctggcaccctcctccaagagcacctctgggggcacagcggccctgggctgcctggtcaaggactacttccccgaaccggtgacggtgtcgtggaactcaggcgccctgaccagcggcgtgcacaccttcccggctgtcctacagtcctcaggactctactccctcagcagcgtggtgaccgtgccctccagcagcttgggcacccagacctacatctgcaacgtgaatcacaagcccagcaacaccaaggtggacaagaaagttgagcccaaatcttgtgacaaaactcacacatgcccaccgtgcccagcacctgaactcctggggggaccgtcagtcttcctcttccccccaaaacccaaggacaccctctacatcacccgggagcctgaggtcacatgcgtggtggtggacgtgagccacgaagaccctgaggtcaagttcaactggtacgtggacggcgtggaggtgcataatgccaagacaaagccgcgggaggagcagtacaacagcacgtaccgtgtggtcagcgtcctcaccgtcctgcaccaggactggctgaatggcaaggagtacaagtgcaaggtgtccaacaaagccctcccagcccccatcgagaaaaccatctccaaagccaaagggcagccccgagaaccacaggtgtacaccctgcccccatcccgggaggagatgaccaagaaccaggtcagcctgacctgcctggtcaaaggcttctatcccagcgacatcgccgtggagtgggagagcaatgggcagccggagaacaactacaagaccacgcctcccgtgctggactccgacggctccttcttcctctacagcaagctcaccgtggacaagagcagatggcagcaggggaacgtcttctcatgctccgtgatgcatgaggctctgcacaaccactacacgcagaagtctctctccctgtctccgggaaaa 663 ADN PAT source 1..663 mol_type other DNA otro ADN note 15N14A LC 15N14A LC organism synthetic construct constructo sintético caggctgttctgacccagcctagctctctgtctgcttctcctggcgcttccgcctctctgacctgcacactgagatccggcatcaacgtgggcacctaccggatctactggtatcagcagaagcctggcagccctcctcagtacctgctgtcctacaagtccgactccgacaagcagcaaggctctggcgtgccctctagattctccggctctaaggacgcctccgccaatgtgggcatcctgctgatctctggcctgcagtctgaggacgaggccgactactactgcatgatctggcactcctccgcctgggttttcggaggcggaacaaagctgacagtcctgggtcagcccaaggctgcacccagtgtcactctgttcccgccctcctctgaggagcttcaagccaacaaggccacactggtgtgtctcataagtgacttctacccgggagccgtgacagtggcctggaaggccgatagcagccccgtcaaggcgggagtcgaaaccaccacaccctccaaacaaagcaacaacaagtacgcggccagcagctatctgagcctgacgcctgagcagtggaagtcccacagaagctacagctgccaggtcacgcatgaagggagcaccgtggagaagacagtggcccctacagaatgttca 1347 ADN PAT source 1..1347 mol_type other DNA otro ADN note 15N14A HC 15N14A HC organism synthetic construct constructo sintético caggttcagctgcaagagtctggacccggcctggtcaagccttccgagacactgtctctgacctgcaccgtgtctggcggctccatctcctcttactattggacctggatcagacagcctgccggcaaaggcctggaatggatcggcagaatcgactcctccggctcctccaagtacaaccccacactgaagtccagagtgaccatgtccgtggacacctccaagaaccagttctccctgaagctgtcctccgtgaccgctgctgataccgccgtgtactactgtgccagaggcgactctggatacgactgggcctttgactattggggccagggcacactggtcaccgtttcttctgcctccaccaagggcccatcggtcttccccctggcaccctcctccaagagcacctctgggggcacagcggccctgggctgcctggtcaaggactacttccccgaaccggtgacggtgtcgtggaactcaggcgccctgaccagcggcgtgcacaccttcccggctgtcctacagtcctcaggactctactccctcagcagcgtggtgaccgtgccctccagcagcttgggcacccagacctacatctgcaacgtgaatcacaagcccagcaacaccaaggtggacaagaaagttgagcccaaatcttgtgacaaaactcacacatgcccaccgtgcccagcacctgaactcctggggggaccgtcagtcttcctcttccccccaaaacccaaggacaccctctacatcacccgggagcctgaggtcacatgcgtggtggtggacgtgagccacgaagaccctgaggtcaagttcaactggtacgtggacggcgtggaggtgcataatgccaagacaaagccgcgggaggagcagtacaacagcacgtaccgtgtggtcagcgtcctcaccgtcctgcaccaggactggctgaatggcaaggagtacaagtgcaaggtgtccaacaaagccctcccagcccccatcgagaaaaccatctccaaagccaaagggcagccccgagaaccacaggtgtacaccctgcccccatcccgggaggagatgaccaagaaccaggtcagcctgacctgcctggtcaaaggcttctatcccagcgacatcgccgtggagtgggagagcaatgggcagccggagaacaactacaagaccacgcctcccgtgctggactccgacggctccttcttcctctacagcaagctcaccgtggacaagagcagatggcagcaggggaacgtcttctcatgctccgtgatgcatgaggctctgcacaaccactacacgcagaagtctctctccctgtctccgggaaaa 642 ADN PAT source 1..642 mol_type other DNA otro ADN note 08F17A LC 08F17A LC organism synthetic construct constructo sintético gacatccagatgacccagtctccatcctctctgtccgcttctgtgggcgacagagtgaccatcacctgtagagcctctcagggcatctcctactacctggcctggtatcagcagaaacccggcaaggtgcccaagctgctgatctctgctgagttcaccctgcagtctggcgtgccctctagattctccggctctggctctggcaccgactttaccctgacaatctccagcctgcagcctgaggatgtggccacctactactgccagaagtacaacaccgctcctcggacctttggccagggcaccaaggtggaaatcaagcgtactgtggctgcaccatctgtcttcatcttcccgccatctgatgagcagttgaaatctggaactgcctctgttgtgtgcctgctgaataacttctatcccagagaggccaaagtacagtggaaggtggataacgccctccaatcgggtaactcccaggagagtgtcacagagcaggacagcaaggacagcacctacagcctcagcagcaccctgacgctgagcaaagcagactacgagaaacacaaagtctacgcctgcgaagtcacccatcagggcctgagctcgcccgtcacaaagagcttcaacaggggagagtgt 1344 ADN PAT source 1..1344 mol_type other DNA otro ADN note 08F17A HC 08F17A HC organism synthetic construct constructo sintético gaggtgcagctggttgaatctggcggaggactggttacccctggcggatctctgagactgtcttgtgccgcctctggcttcaccttctccggctactctatgaactgggtccgacaggctcctggcaaaggcctggaatgggtgtcctccatctcctccagcagcggctacatctactacgccgactccgtgaagggcagattcaccatctccagagacaacgccaagaactccctgtacctgcagatgaacagcctgagagccgaggacaccgccgtgtactactgtgccagagagtattggggctccggcttcgattattggggccaaggaacactggtcaccgtgtcctctgcctccaccaagggcccatcggtcttccccctggcaccctcctccaagagcacctctgggggcacagcggccctgggctgcctggtcaaggactacttccccgaaccggtgacggtgtcgtggaactcaggcgccctgaccagcggcgtgcacaccttcccggctgtcctacagtcctcaggactctactccctcagcagcgtggtgaccgtgccctccagcagcttgggcacccagacctacatctgcaacgtgaatcacaagcccagcaacaccaaggtggacaagaaagttgagcccaaatcttgtgacaaaactcacacatgcccaccgtgcccagcacctgaactcctggggggaccgtcagtcttcctcttccccccaaaacccaaggacaccctctacatcacccgggagcctgaggtcacatgcgtggtggtggacgtgagccacgaagaccctgaggtcaagttcaactggtacgtggacggcgtggaggtgcataatgccaagacaaagccgcgggaggagcagtacaacagcacgtaccgtgtggtcagcgtcctcaccgtcctgcaccaggactggctgaatggcaaggagtacaagtgcaaggtgtccaacaaagccctcccagcccccatcgagaaaaccatctccaaagccaaagggcagccccgagaaccacaggtgtacaccctgcccccatcccgggaggagatgaccaagaaccaggtcagcctgacctgcctggtcaaaggcttctatcccagcgacatcgccgtggagtgggagagcaatgggcagccggagaacaactacaagaccacgcctcccgtgctggactccgacggctccttcttcctctacagcaagctcaccgtggacaagagcagatggcagcaggggaacgtcttctcatgctccgtgatgcatgaggctctgcacaaccactacacgcagaagtctctctccctgtctccgggaaaa 269 AA PAT source 1..269 mol_type protein proteína note IL-1beta (Uniprot ID P01584) IL-1beta (Ident. de Uniprot P01584) organism Homo sapiens Homo sapiens MAEVPELASEMMAYYSGNEDDLFFEADGPKQMKCSFQDLDLCPLDGGIQLRISDHHYSKGFRQAASVVVAMDKLRKMLVPCPQTFQENDLSTFFPFIFEEEPIFFDTWDNEAYVHDAPVRSLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKEKNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYISTSQAENMPVFLGGTKGGQDITDFTMQFVSS 153 AA PAT source 1..153 mol_type protein proteína note the fragment of SEQ ID NO: 109 el fragmento de la sec. con núm. de ident.: 109 organism synthetic construct constructo sintético APVRSLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKEKNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYISTSQAENMPVFLGGTKGGQDITDFTMQFVSS