WO 210196-209003/PCT US 63/328,015 2022-04-06 MiroBio Limited MiroBio Limited ENGINEERED CD200R ANTIBODIES AND USES THEREOF ANTICUERPOS CD200R DISEÑADOS POR INGENIERÍA Y USOS DE ESTOS 98 114 AA PAT source 1..114 mol_type protein organism synthetic construct Constructo sintético QVQLQQPGSELVRPGASVKLSCKASGHTFTSYWMHWVKQRPGQGLEWIGNIYPGSGSINYDEKFKSKAKLTVDTSSRTAYMQLSSLTSEDSAVYYCLTMTGTSWGQGTLVTVSA 107 AA PAT source 1..107 mol_type protein organism synthetic construct Constructo sintético DVQMIQSPSSLSASLGDIVTMTCQASQGTPINLHWFQQKPGKAPKLLISGASNLEDGVPSRFSGSRYGTAFTLTISSLEDEDMATYFCLQFTYIPWTFGGGTKLEIK 5 AA PAT source 1..5 mol_type protein organism synthetic construct Constructo sintético SYWMH 17 AA PAT source 1..17 mol_type protein organism synthetic construct Constructo sintético NIYPGSGSINYDEKFKS 5 AA PAT source 1..5 mol_type protein organism synthetic construct Constructo sintético MTGTS 11 AA PAT source 1..11 mol_type protein organism synthetic construct Constructo sintético QASQGTPINLH 7 AA PAT source 1..7 mol_type protein organism synthetic construct Constructo sintético GASNLED 9 AA PAT source 1..9 mol_type protein organism synthetic construct Constructo sintético LQFTYIPWT 119 AA PAT source 1..119 mol_type protein organism synthetic construct Constructo sintético EVQLQQSGPELVKPGASVKMSCKASGYTFTSYVMHWVKQKPGQGLEWIGYIHPYNDDIKHNEKFKDKATLTSAKSSSTVYMELSSLTSEDSAVYYCAREEYYGSRFAYWGQGTLVTVSA 111 AA PAT source 1..111 mol_type protein organism synthetic construct Constructo sintético DIVLTQSPASLAVSLGQRATISCRASKSVRTSGYSYLHWYQQKPGQPPKLLIYLASNLESGVPARFSGSGSGTDFTLNIHPVEEEDAATYYCQYSGELPFTFGGGTKLEIK 5 AA PAT source 1..5 mol_type protein organism synthetic construct Constructo sintético SYVMH 17 AA PAT source 1..17 mol_type protein organism synthetic construct Constructo sintético YIHPYNDDIKHNEKFKD 10 AA PAT source 1..10 mol_type protein organism synthetic construct Constructo sintético EEYYGSRFAY 15 AA PAT source 1..15 mol_type protein organism synthetic construct Constructo sintético RASKSVRTSGYSYLH 7 AA PAT source 1..7 mol_type protein organism synthetic construct Constructo sintético LASNLES 9 AA PAT source 1..9 mol_type protein organism synthetic construct Constructo sintético QYSGELPFT 117 AA PAT source 1..117 mol_type protein organism synthetic construct Constructo sintético QVQLKESGPGLVAPSQSLSITCTVSGFSLTSYGVHWVRQLPGKGLEWLGVIWAGGGTNYNSALMSRLSISKDNSKSQVFLKMNRLQTDDTAIYYCAREGLPRAMDYWGQGTSVTVSS 107 AA PAT source 1..107 mol_type protein organism synthetic construct Constructo sintético DIVLTQSPASLAVSLGQRATISCRASESVDNYGISFMNWFQQKPGQPPKLLSNQGSGVPARFSGSGSGTDFSLNIHPMEEDDTAMYFCQQGKEFPWTFGGGTKLEIN 5 AA PAT source 1..5 mol_type protein organism synthetic construct Constructo sintético SYGVH 16 AA PAT source 1..16 mol_type protein organism synthetic construct Constructo sintético VIWAGGGTNYNSALMS 9 AA PAT source 1..9 mol_type protein organism synthetic construct Constructo sintético EGLPRAMDY 15 AA PAT source 1..15 mol_type protein organism synthetic construct Constructo sintético RASESVDNYGISFMN 7 AA PAT source 1..7 mol_type protein organism synthetic construct Constructo sintético QGSGVPA 9 AA PAT source 1..9 mol_type protein organism synthetic construct Constructo sintético QQGKEFPWT 114 AA PAT source 1..114 mol_type protein organism synthetic construct Constructo sintético QVQLQQPGSELVRPGASVKLSCKASGYTFTSYWMHWVKQRPGQGLEWIGNIFPGSDTTNYDEKFKSKAIMTVDISSSTVYMHLSSLTSEDSAVYYCITYTGAYWGQGTLVTVSA 107 AA PAT source 1..107 mol_type protein organism synthetic construct Constructo sintético DVQMIQSPSSLSASMGDIVTMTCQASQGTNINLHWFQQKPGKAPKLLISGGSNLEDGVPSRFSGSRYGTDFTLTISSLEDEDMATYFCLQFTYLPWTFGGGTKLDIK 5 AA PAT source 1..5 mol_type protein organism synthetic construct Constructo sintético SYWMH 17 AA PAT source 1..17 mol_type protein organism synthetic construct Constructo sintético NIFPGSDTTNYDEKFKS 5 AA PAT source 1..5 mol_type protein organism synthetic construct Constructo sintético YTGAY 11 AA PAT source 1..11 mol_type protein organism synthetic construct Constructo sintético QASQGTNINLH 7 AA PAT source 1..7 mol_type protein organism synthetic construct Constructo sintético GGSNLED 9 AA PAT source 1..9 mol_type protein organism synthetic construct Constructo sintético LQFTYLPWT 114 AA PAT source 1..114 mol_type protein organism synthetic construct Constructo sintético QVQLQQPGSELVRPGASVKLSCKASGYTFTSYWMHWVKQRPGQGLEWIGNIYPGSGTTNYDEKFKSKATLTVDTSSSTAYMQISSLTSEDSAVYYCTTGTSTYWGQGTLVTVSA 107 AA PAT source 1..107 mol_type protein organism synthetic construct Constructo sintético DVQMIQSPSSLSASLGDIVTMTCQASQGTSINLNWFQQKPGKAPKLLIYGAVNLEDGVPSRFSGSRYGTDFTLTVSSLEDEDMATYFCLQHTYLPWTFGGGTKLEIK 5 AA PAT source 1..5 mol_type protein organism synthetic construct Constructo sintético SYWMH 17 AA PAT source 1..17 mol_type protein organism synthetic construct Constructo sintético NIYPGSGTTNYDEKFKS 5 AA PAT source 1..5 mol_type protein organism synthetic construct Constructo sintético GTSTY 11 AA PAT source 1..11 mol_type protein organism synthetic construct Constructo sintético QASQGTSINLN 7 AA PAT source 1..7 mol_type protein organism synthetic construct Constructo sintético GAVNLED 9 AA PAT source 1..9 mol_type protein organism synthetic construct Constructo sintético LQHTYLPWT 17 AA PAT source 1..17 mol_type protein organism synthetic construct Constructo sintético NIYPGSGSINYDEKFKS 114 AA PAT source 1..114 mol_type protein organism synthetic construct Constructo sintético QVQLVQSGSELKKPGASVKLSCKASGHTFTSYWMHWVKQAPGQGLEWIGNIYPGSGSINYDEKFQGRATLTVDTSTRTAYMELSSLRSEDSAVYYCLTMTGTSWGRGTLVTVSS 114 AA PAT source 1..114 mol_type protein organism synthetic construct Constructo sintético QVQLVQSGAEVKKPGASVKLSCKASGHTFTSYWMHWVKQAPGQGLEWIGNIYPGSGSINYDEKFQGRATLTVDTSTRTAYMELSSLRSEDTAVYYCLTMTGTSWGRGTLVTVSS 114 AA PAT source 1..114 mol_type protein organism synthetic construct Constructo sintético QVQLVQSGAEVKKPGASVKVSCKASGHTFTSYWMHWVRQAPGQGLEWIGNIYPGSGSINYDEKFQGRVTMTVDTSTSTAYMELSSLRSEDTAVYYCLTMTGTSWGRGTLVTVSS 114 AA PAT source 1..114 mol_type protein organism synthetic construct Constructo sintético QVQLVQSGAEVKKPGASVKVSCKASGHTFTSYWMHWVRQAPGQGLEWMGNIYPGSGSINYDEKFQGRVTMTADTSTSTVYMELSSLRSEDTAVYYCLTMTGTSWGRGTLVTVSS 114 AA PAT source 1..114 mol_type protein organism synthetic construct Constructo sintético QVQLVQSGAEVKKPGASVKVSCKASGHTFTSYWMHWVRQAPGQGLEWMGNIYPGSGSINYDEKFQGRGTITTDTSTTTRYMELSSLRSEDTAVYYCLTMTGTSWGRGTLVTVSS 114 AA PAT source 1..114 mol_type protein organism synthetic construct Constructo sintético QVQLVQSGAEVKKPGASVKVSCKASGHTFTSYWMHWVRQAPGQGLEWMGNIYPGSGSINYDEKFQGRGTITTDTSTTTRYMELSSLRSEDTAVYYCTTMTGTSWGRGTLVTVSS 107 AA PAT source 1..107 mol_type protein organism synthetic construct Constructo sintético DVQMTQSPSSLSVSVGDRVTMTCQASQGTPINLHWFQQKPGKAPKLLISGASNLEDGVPSRFSGSRYGTAFTLTISSLQDEDIATYFCLQFTYIPWTFGQGTKLEIK 107 AA PAT source 1..107 mol_type protein organism synthetic construct Constructo sintético DVQMTQSPSSLSVSVGDRVTMTCQASQGTPINLHWFQQKPGKAPKLLISGASNLEDGVPSRFSGSRYGTAFTLTISSLQPEDIATYFCLQFTYIPWTFGQGTKLEIK 107 AA PAT source 1..107 mol_type protein organism synthetic construct Constructo sintético DVQMTQSPSSLSVSVGDRVTITCQASQGTPINLHWFQQKPGKAPKLLISGASNLEDGVPSRFSGSRYGTDFTFTISSLQPEDIATYFCLQFTYIPWTFGQGTKLEIK 107 AA PAT source 1..107 mol_type protein organism synthetic construct Constructo sintético DIQMTQSPSSLSVSVGDRVTITCQASQGTPINLHWFQQKPGKAPKLLISGASNLEDGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCLQFTYIPWTFGQGTKLEIK 107 AA PAT source 1..107 mol_type protein organism synthetic construct Constructo sintético DIQMTQSPSSLSVSVGDRVTITCQASQGTPINLHWFQQKPGKAPKLLISGASNLEDGVPSRFSGSGSGTEFTFTISSLQPEDAATYYCLQFTYIPWTFGQGTKLEIK 120 AA PAT source 1..120 mol_type protein organism synthetic construct Constructo sintético QVQLVQSGAEVKKPGASVKVSCKASGFSFSSGYYMAWVRQAPGQGLEWMGLIGVGSGSLWYAQKFQGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARHFALSDPFNLWGQGTLVTVSS 108 AA PAT source 1..108 mol_type protein organism synthetic construct Constructo sintético EIVLTQSPDFQSVTPKEKVTITCQASESIDSYLLWYQQKPDQSPKLLIKQASTLASGVPSRFSGSGSGTDFTLTINSLEAEDAATYYCQNYYDISSNDFGGGTKVEIK 6 AA PAT source 1..6 mol_type protein organism synthetic construct Constructo sintético SGYYMA 17 AA PAT source 1..17 mol_type protein organism synthetic construct Constructo sintético LIGVGSGSLWYAQKFQG 10 AA PAT source 1..10 mol_type protein organism synthetic construct Constructo sintético HFALSDPFNL 11 AA PAT source 1..11 mol_type protein organism synthetic construct Constructo sintético QASESIDSYLL 7 AA PAT source 1..7 mol_type protein organism synthetic construct Constructo sintético QASTLAS 10 AA PAT source 1..10 mol_type protein organism synthetic construct Constructo sintético QNYYDISSND 330 AA PAT source 1..330 mol_type protein organism unidentified No identificado ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGDSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 107 AA PAT source 1..107 mol_type protein organism Homo sapiens Homo sapiens RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 324 AA PAT source 1..324 mol_type protein organism unidentified No identificado AKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDCGCKPCICTVPEVSSVFIFPPKPKDVLTITLTPKVTCVVVDISKDDPEVQFSWFVDDVEVHTAQTQPREEQFNSTFRSVSELPIMHQDWLNGKEFKCRVNSAAFPAPIEKTISKTKGRPKAPQVYTIPPPKEQMAKDKVSLTCMITDFFPEDITVEWQWNGQPAENYKNTQPIMDTDGSYFVYSKLNVQKSNWEAGNTFTCSVLHEGLHNHHTEKSLSHSPGK 107 AA PAT source 1..107 mol_type protein organism unidentified No identificado RADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC 107 AA PAT source 1..107 mol_type protein organism synthetic construct Constructo sintético DIQMTQSPSSLSVSVGDRVTITCQASQGTPINLHWFQQKPGKAPKLLISGASNLESGVPSRFSGSGSGTEFTFTISSLQPEDAATYYCLQFTYIPWTFGQGTKLEIK 107 AA PAT source 1..107 mol_type protein organism synthetic construct Constructo sintético DIQMTQSPSSLSVSVGDRVTITCQASQGTPINLHWFQQKPGKAPKLLISGASNLETGVPSRFSGSGSGTEFTFTISSLQPEDAATYYCLQFTYIPWTFGQGTKLEIK 7 AA PAT source 1..7 mol_type protein organism unidentified No identificado GASNLES 7 AA PAT source 1..7 mol_type protein organism unidentified No identificado GASNLET 5 AA PAT source 1..5 mol_type protein organism synthetic construct Constructo sintético SITE 1 note X is M or G X es M o G XTGTS 5 AA PAT source 1..5 mol_type protein organism synthetic construct Constructo sintético GTGTS 114 AA PAT source 1..114 mol_type protein organism synthetic construct Constructo sintético EVQLVQSGAEVKKPGASVKVSCKASGHTFTSYWMHWVRQAPGQGLEWMGNIYPGSGSINYDEKFQGRVTMTADTSTSTVYMELSSLRSEDTAVYYCLTMTGTSWGRGTLVTVSS 114 AA PAT source 1..114 mol_type protein organism synthetic construct Constructo sintético EVQLVQSGAEVKKPGASVKVSCKASGHTFTSYWMHWVRQAPGQGLEWMGNIYPGSGSINYDEKFQGRVTMTADTSTSTVYMELSSLRSEDTAVYYCLTGTGTSWGRGTLVTVSS 446 AA PAT source 1..446 mol_type protein organism synthetic construct Constructo sintético QVQLVQSGAEVKKPGASVKVSCKASGFSFSSGYYMAWVRQAPGQGLEWMGLIGVGSGSLWYAQKFQGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARHFALSDPFNLWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG 215 AA PAT source 1..215 mol_type protein organism synthetic construct Constructo sintético EIVLTQSPDFQSVTPKEKVTITCQASESIDSYLLWYQQKPDQSPKLLIKQASTLASGVPSRFSGSGSGTDFTLTINSLEAEDAATYYCQNYYDISSNDFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 330 AA PAT source 1..330 mol_type protein organism Homo sapiens Homo sapiens ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 327 AA PAT source 1..327 mol_type protein organism Homo sapiens Homo sapiens ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK 330 AA PAT source 1..330 mol_type protein organism synthetic construct Constructo sintético SITE 121 note X is D or P X es D o P SITE 329 note X is G or absent X es G o ausente SITE 330 note X is K or absent X es K o ausente ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGXSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPXX 327 AA PAT source 1..327 mol_type protein organism synthetic construct Constructo sintético SITE 327 note X is K or absent X es K o ausente SITE 326 note X is G or absent X es G o ausente SITE 108 note X is S or P X es S o P ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPXCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLXX 444 AA PAT source 1..444 mol_type protein organism synthetic construct Constructo sintético QVQLVQSGAEVKKPGASVKVSCKASGHTFTSYWMHWVRQAPGQGLEWMGNIYPGSGSINYDEKFQGRVTMTADTSTSTVYMELSSLRSEDTAVYYCLTMTGTSWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGDSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 444 AA PAT source 1..444 mol_type protein organism synthetic construct Constructo sintético EVQLVQSGAEVKKPGASVKVSCKASGHTFTSYWMHWVRQAPGQGLEWMGNIYPGSGSINYDEKFQGRVTMTADTSTSTVYMELSSLRSEDTAVYYCLTMTGTSWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGDSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 444 AA PAT source 1..444 mol_type protein organism synthetic construct Constructo sintético EVQLVQSGAEVKKPGASVKVSCKASGHTFTSYWMHWVRQAPGQGLEWMGNIYPGSGSINYDEKFQGRVTMTADTSTSTVYMELSSLRSEDTAVYYCLTGTGTSWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGDSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 444 AA PAT source 1..444 mol_type protein organism Homo sapiens Homo sapiens EVQLVQSGAEVKKPGASVKVSCKASGHTFTSYWMHWVRQAPGQGLEWMGNIYPGSGSINYDEKFQGRVTMTADTSTSTVYMELSSLRSEDTAVYYCLTGTGTSWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 441 AA PAT source 1..441 mol_type protein organism Homo sapiens Homo sapiens EVQLVQSGAEVKKPGASVKVSCKASGHTFTSYWMHWVRQAPGQGLEWMGNIYPGSGSINYDEKFQGRVTMTADTSTSTVYMELSSLRSEDTAVYYCLTGTGTSWGRGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK 444 AA PAT source 1..444 mol_type protein organism Homo sapiens Homo sapiens EVQLVQSGAEVKKPGASVKVSCKASGHTFTSYWMHWVRQAPGQGLEWMGNIYPGSGSINYDEKFQGRVTMTADTSTSTVYMELSSLRSEDTAVYYCLTMTGTSWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 441 AA PAT source 1..441 mol_type protein organism Homo sapiens Homo sapiens EVQLVQSGAEVKKPGASVKVSCKASGHTFTSYWMHWVRQAPGQGLEWMGNIYPGSGSINYDEKFQGRVTMTADTSTSTVYMELSSLRSEDTAVYYCLTMTGTSWGRGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK 214 AA PAT source 1..214 mol_type protein organism synthetic construct Constructo sintético DIQMTQSPSSLSVSVGDRVTITCQASQGTPINLHWFQQKPGKAPKLLISGASNLESGVPSRFSGSGSGTEFTFTISSLQPEDAATYYCLQFTYIPWTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 000 7 AA PAT source 1..7 mol_type protein organism synthetic construct Constructo sintético SITE 1 note X is G or L X es G o L SITE 3 note X is D, S or T X es D, S o T XAXNLEX 7 AA PAT source 1..7 mol_type protein organism synthetic construct Constructo sintético SITE 1 note X is G or L X es G o L SITE 7 note X is D, S or T X es D, S o T XASNLEX 7 AA PAT source 1..7 mol_type protein organism synthetic construct Constructo sintético SITE 2 note X is A or G X es A o G SITE 7 note X is D, S or T X es D, S o T GXSNLEX 9 AA PAT source 1..9 mol_type protein organism synthetic construct Constructo sintético SITE 8 note X is W or F X es W o F LQFTYIPXT 5 AA PAT source 1..5 mol_type protein organism synthetic construct Constructo sintético SITE 3 note X is W or F X es W o F SYXMH 114 AA PAT source 1..114 mol_type protein organism synthetic construct Constructo sintético SITE 33 note X is W or F X es W o F SITE 99 note X is M or G X es M o G SITE 1 note X is Q or E X es Q o E XVQLVQSGAEVKKPGASVKVSCKASGHTFTSYXMHWVRQAPGQGLEWMGNIYPGSGSINYDEKFQGRVTMTADTSTSTVYMELSSLRSEDTAVYYCLTXTGTSWGRGTLVTVSS 107 AA PAT source 1..107 mol_type protein organism synthetic construct Constructo sintético SITE 52 note X is S or V X es S o V SITE 96 note X is W or F X es W o F SITE 56 note X is D, S or T X es D, S o T SITE 51 note X is A or G X es A o G SITE 50 note X is G or L X es G o L DIQMTQSPSSLSVSVGDRVTITCQASQGTPINLHWFQQKPGKAPKLLISXXXNLEXGVPSRFSGSGSGTEFTFTISSLQPEDAATYYCLQFTYIPXTFGQGTKLEIK 444 AA PAT source 1..444 mol_type protein organism synthetic construct Constructo sintético SITE 443 note X is G or absent X es G o ausente SITE 235 note X is D or P X es D o P SITE 99 note X is M or G X es M o G SITE 33 note X is W or F X es W o F SITE 1 note X is D or E X es D o E SITE 444 note X is K or absent X es K o ausente XVQLVQSGAEVKKPGASVKVSCKASGHTFTSYXMHWVRQAPGQGLEWMGNIYPGSGSINYDEKFQGRVTMTADTSTSTVYMELSSLRSEDTAVYYCLTXTGTSWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGXSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPXX 441 AA PAT source 1..441 mol_type protein organism synthetic construct Constructo sintético SITE 440 note X is G or absent X es G o ausente SITE 441 note X is K or absent X es K o ausente SITE 222 note X is S or P X es S o P SITE 99 note X is M or G X es M o G SITE 33 note X is W or F X es W o F SITE 1 note X is D or E X es D o E XVQLVQSGAEVKKPGASVKVSCKASGHTFTSYXMHWVRQAPGQGLEWMGNIYPGSGSINYDEKFQGRVTMTADTSTSTVYMELSSLRSEDTAVYYCLTXTGTSWGRGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPXCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLXX 438 AA PAT source 1..438 mol_type protein organism unidentified No identificado SITE 1 note X is D or E X es D o E SITE 33 note X is W or F X es W o F SITE 99 note X is M or G X es M o G SITE 437 note X is G or absent X es G o ausente SITE 438 note X is K or absent X es K o ausente XVQLVQSGAEVKKPGASVKVSCKASGHTFTSYXMHWVRQAPGQGLEWMGNIYPGSGSINYDEKFQGRVTMTADTSTSTVYMELSSLRSEDTAVYYCLTXTGTSWGRGTLVTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDCGCKPCICTVPEVSSVFIFPPKPKDVLTITLTPKVTCVVVDISKDDPEVQFSWFVDDVEVHTAQTQPREEQFNSTFRSVSELPIMHQDWLNGKEFKCRVNSAAFPAPIEKTISKTKGRPKAPQVYTIPPPKEQMAKDKVSLTCMITDFFPEDITVEWQWNGQPAENYKNTQPIMDTDGSYFVYSKLNVQKSNWEAGNTFTCSVLHEGLHNHHTEKSLSHSPXX 214 AA PAT source 1..214 mol_type protein organism synthetic construct Constructo sintético SITE 52 note X is S or V X es S o V SITE 51 note X is A or G X es A o G SITE 50 note X is G or L X es G o L SITE 96 note X is W or F X es W o F SITE 56 note X is D, S or T X es D, S o T DIQMTQSPSSLSVSVGDRVTITCQASQGTPINLHWFQQKPGKAPKLLISXXXNLEXGVPSRFSGSGSGTEFTFTISSLQPEDAATYYCLQFTYIPXTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC